MCID: SPT004
MIFTS: 57

Septic Arthritis

Categories: Blood diseases, Bone diseases, Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Septic Arthritis

MalaCards integrated aliases for Septic Arthritis:

Name: Septic Arthritis 12 52 15
Infectious Arthritis 12 74 52 42 17
Arthritis, Infectious 43 71
Arthritis, Bacterial 71
Arthritis Septic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:813
MeSH 43 D001170
NCIt 49 C26700
ICD10 32 M00 M00.9
UMLS 71 C0003869 C0157843 C0157844 more

Summaries for Septic Arthritis

MedlinePlus : 42 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to shigellosis and arthritis, and has symptoms including fever, pruritus and back pain. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hyaluronic acid and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 52 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis , which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 74 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Related Diseases for Septic Arthritis

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 573)
# Related Disease Score Top Affiliating Genes
1 shigellosis 32.3 TLR5 TLR4 CXCL8
2 arthritis 31.7 TLR4 TLR2 MMP3 MMP1 IFNG CXCL8
3 haemophilus influenzae 31.6 TLR2 CXCL8
4 synovitis 31.4 MMP3 MMP1 CXCL8 CRP
5 prosthetic joint infection 31.3 TLR4 TLR2 CRP
6 endocarditis 31.2 TREM1 TLR2 IFNG CXCL8 CRP
7 mycobacterium kansasii 31.2 TLR2 CXCL8
8 mycobacterium marinum 31.1 TLR2 CXCL8
9 infective endocarditis 31.1 TREM1 TLR2 CRP
10 osteoarthritis 30.9 MMP3 MMP1 CXCL8 CRP
11 endophthalmitis 30.9 TLR2 CXCL8 CRP
12 lyme disease 30.8 TLR9 TLR2 CRP
13 toxic shock syndrome 30.8 TREM1 TLR4 TLR2 IFNG CXCL8 CRP
14 arthropathy 30.8 MMP3 MMP2 MMP1 IFNG CRP
15 juvenile rheumatoid arthritis 30.7 MMP3 IFNG CXCL8 CRP
16 osteomyelitis 30.7 TLR4 TLR2 PPP3CA IFNG CXCL8 CALCA
17 neurofibromatosis, type ii 30.7 TLR2 DEFB4A CXCL8
18 acute cystitis 30.7 TLR5 TLR4 TLR2 CXCL8 CRP
19 brucellosis 30.6 TLR4 IFNG CXCL8 CRP
20 fasciitis 30.6 MMP1 IFNG CXCL8
21 pericarditis 30.6 IFNG CXCL8 CRP
22 melioidosis 30.6 TREM1 TLR5 TLR4 TLR2 IFNG
23 reactive arthritis 30.6 TLR4 TLR2 IFNG CXCL8 CRP
24 spondyloarthropathy 1 30.6 TLR4 MMP3 CRP
25 typhoid fever 30.6 TLR5 TLR4 IFNG CRP
26 sarcoidosis 1 30.6 IFNG CXCR3 CRP CCL18
27 discitis 30.5 CRP CALCA
28 chickenpox 30.5 TLR9 TLR3 IFNG CRP
29 granulomatosis with polyangiitis 30.5 TLR9 TLR4 TLR2 CRP
30 familial mediterranean fever 30.4 TLR4 TLR2 CRP
31 otitis media 30.4 TLR5 TLR4 TLR2 IFNG CXCL8 CRP
32 conjunctivitis 30.4 TLR3 IFNG CXCL8
33 acute pyelonephritis 30.4 CXCL8 CRP CALCA
34 mycobacterium abscessus 30.3 TLR2 CXCL8
35 meningococcal meningitis 30.3 TLR9 TLR4 TLR2
36 peritonitis 30.3 TLR4 TLR2 IFNG CXCL8 CRP
37 ileitis 30.3 TLR5 TLR4 TLR2
38 lepromatous leprosy 30.2 TLR2 IFNG CCL18
39 meningitis 30.2 TLR9 TLR4 TLR2 IFNG CXCL8 CRP
40 autoimmune disease 30.2 TLR9 IFNG CXCR3 CXCL8 CRP
41 neurogenic arthropathy 30.2 CRP CALCA
42 herpes zoster 30.2 TLR2 IFNG CRP
43 gastroenteritis 30.2 TLR9 IFNG CXCL8 CRP CALCA
44 myeloma, multiple 30.2 TLR9 TLR4 TLR3 MMP2 IFNG CXCL8
45 pyoderma 30.2 MMP1 CXCL8 CRP
46 pyelonephritis 30.2 TLR4 IFNG CXCL8 CRP CALCA
47 acute cholangitis 30.2 TREM1 CRP CALCA
48 allergic contact dermatitis 30.1 IFNG CXCR3 CXCL8
49 appendicitis 30.1 TLR4 MMP3 IFNG CXCL8 CRP
50 chorioamnionitis 30.0 TREM1 TLR4 MMP1 CXCL8 CRP

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis

Symptoms & Phenotypes for Septic Arthritis

UMLS symptoms related to Septic Arthritis:


fever, pruritus, back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Septic Arthritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CXCR3 IFNG ITGA2 MMP2 MMP3 MMP7
2 homeostasis/metabolism MP:0005376 10.03 CRP CXCR3 IFNG ITGA2 MMP1 MMP2
3 immune system MP:0005387 9.8 CRP CXCR3 IFNG MMP1 MMP2 MMP3
4 neoplasm MP:0002006 9.28 CXCR3 IFNG MMP1 MMP2 MMP7 TLR2

Drugs & Therapeutics for Septic Arthritis

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
5
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
6
Fosfomycin Approved Phase 4 23155-02-4 446987
7
Vancomycin Approved Phase 4 1404-90-6 441141 14969
8
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
9
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
10 Immunologic Factors Phase 4
11 Viscosupplements Phase 4
12 Adjuvants, Immunologic Phase 4
13 Cytochrome P-450 Enzyme Inhibitors Phase 4
14 Cytochrome P-450 CYP3A Inhibitors Phase 4
15 Antiparasitic Agents Phase 4
16 Hormone Antagonists Phase 4
17 Antiprotozoal Agents Phase 4
18 Pharmaceutical Solutions Phase 4
19 Antifungal Agents Phase 4
20 Liposomal amphotericin B Phase 4
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
22 Steroid Synthesis Inhibitors Phase 4
23 Coagulase Phase 4
24
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
25
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
26
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
27 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
28
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
29
Zoledronic Acid Approved Phase 2, Phase 3 118072-93-8 68740
30
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
31 Immunoglobulins Phase 3
32 Antibodies Phase 3
33 Immunoglobulins, Intravenous Phase 3
34 Rho(D) Immune Globulin Phase 3
35 gamma-Globulins Phase 3
36 Protective Agents Phase 2, Phase 3
37 Anti-Inflammatory Agents Phase 2, Phase 3
38 Antiemetics Phase 2, Phase 3
39 Gastrointestinal Agents Phase 2, Phase 3
40 Methylprednisolone Acetate Phase 2, Phase 3
41 Autonomic Agents Phase 2, Phase 3
42 Diphosphonates Phase 2, Phase 3
43 Antineoplastic Agents, Hormonal Phase 2, Phase 3
44 Neuroprotective Agents Phase 2, Phase 3
45 glucocorticoids Phase 2, Phase 3
46 Antitubercular Agents Phase 3
47 Antibiotics, Antitubercular Phase 3
48
Clindamycin Approved, Vet_approved Phase 2 18323-44-9 29029
49
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
50
Cefazolin Approved Phase 2 25953-19-9 656510 33255

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Randomized Open Label Study of Oral Versus Intravenous Antibiotic Treatment for Bone and Joint Infections Requiring Prolonged Antibiotic Treatment: Multi-centre Study Completed NCT00974493 Phase 4 Antibiotics
3 The Use of Antifungal Lock Therapy in Intestinal Failure and Other Patients Completed NCT00936910 Phase 4 amphotericin B liposomal (Ambisome)
4 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
5 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
6 Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection (PJI) Caused by Staphylococci, Streptococci, Enterococci and Gram-negative Bacilli, Including Mixed Infections and Culture Negative PJI's ("PROOF-Study") Recruiting NCT03260010 Phase 4 Fosfomycin
7 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
8 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
9 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
10 A Phase III, Multicenter, Open-Label Study To Evaluate The Efficacy, Safety, and Pharmacokinetics of Gammaplex® in Primary Immunodeficiency Diseases Completed NCT00278954 Phase 3
11 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
12 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
13 Arthrotomy With Irrigation and Debridement Versus Serial Arthrocentesis as Treatment for Septic Arthritis in Adults Withdrawn NCT00313365 Phase 3
14 Randomised, Placebo Controlled Study to Determine if Aquamin (as AquaCal and AquaPT) Modulates Inflammatory Biomarkers in the Blood of Osteoarthritis and Healthy Subjects Completed NCT01321281 Phase 2
15 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
16 Randomized Open-label Active-controlled Study to Assess the Safety, Tolerability, and Efficacy of Afabicin IV/Oral in the Treatment of Patients With Bone or Joint Infection Due to Staphylococcus Active, not recruiting NCT03723551 Phase 2 Afabicin;SOC
17 Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection Terminated NCT01756924 Phase 2 CEM-102;IV or Oral standard of care antibiotics;Rifampin
18 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
19 Early Diagnostics of Septic Arthritis and Periprosthetic Joint Infections With Calorimetry and Polymerase Chain Reaction (PCR) of Synovial Aspirate Fluid Unknown status NCT02530229
20 Personalized Immunotherapeutic for Antibiotic-resistant Infection Unknown status NCT02508584 Early Phase 1
21 Benefit of Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection Unknown status NCT03038464
22 Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy Unknown status NCT01957228
23 The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection Unknown status NCT03200470
24 Efficacy and Safety of Fast-track Treatment for Prosthetic Joint Infection (PJI) Unknown status NCT02372435
25 ARTEMIS Synovial Markers in Arthritis Childhood Completed NCT02505828
26 Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis Completed NCT03615781 Two week's arm - drugs;Four week's arm - drugs
27 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
28 Ultrasonography Assessment of Septic Arthritis on Native Joint: a Descriptive, Exploratory, Prospective, Multicentric Trial Completed NCT02018952
29 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
30 Caractérisation de Nouveaux Biomarqueurs de l'Arthrite Septique Par Technique SELDI-TOF Completed NCT01010165
31 Implant-Associated P. Aeruginosa Bone And Joint Infections : Experience In A Regional Reference Center In France Completed NCT03624855
32 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Completed NCT03768635
33 Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection Completed NCT03808285
34 Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections Completed NCT03848104
35 Procalcitonin Level as a Prognostic Marker and Its' Kinetics in Children With Bacterial Infections Completed NCT00714402
36 One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections Completed NCT03473392
37 Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections Completed NCT03403608
38 Cost of Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03612076
39 Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03627000
40 Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration Completed NCT03177369
41 Pristinamycin in the Treatment of MSSA Bone and Joint Infection Completed NCT03177343
42 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections Completed NCT03209921
43 A Retrospective, Blinded Validation Study to Assess the Accuracy of a Host-response Based Diagnostics for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients With an Acute Febrile Disease Completed NCT01911143
44 Concordance Entre l'échographie du Genou et la Radiographie Standard Dans la détection Des Calcifications Dans le Cadre de la Chondrocalcinose Articulaire Completed NCT00797537
45 A Prospective Study on the Diagnosis, Severity and Prognosis of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Related Complications Completed NCT01333657
46 InterventiOnal Study of Bone and Joint Infections Related Gut dysbiosIS Completed NCT03011502
47 Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection Completed NCT03191292
48 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center Completed NCT03209934
49 Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection Completed NCT02806063
50 Prolonged Oral Levofloxacin-Rifampin for Staphylococcus Aureus Prosthetic Joint Infection (PJI) Treated With Debridement And Retention Of Components: A Prospective Observational Cohort Study. Mayo PJI Study Group (MPSG)* Completed NCT00279864

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

19
Joint

MalaCards organs/tissues related to Septic Arthritis:

40
Bone, Testes, Liver, Skin, Kidney, Lung, Bone Marrow

Publications for Septic Arthritis

Articles related to Septic Arthritis:

(show top 50) (show all 5821)
# Title Authors PMID Year
1
Identifying Predictive Factors of Pediatric Septic Arthritis of the Knee in a Lyme Endemic Area. 61 42
31513518 2018
2
Smoking cessation intervention for reducing disease activity in chronic autoimmune inflammatory joint diseases. 42
31476270 2019
3
Periodontopathogenic bacteria in prosthetic joint infection: a retrospective analysis of 1,673 patients. 42
31482153 2019
4
Serum procalcitonin for discrimination between septic and non-septic arthritis. 54 61
18578968 2008
5
Septic arthritis due to extended spectrum beta lactamase producing Klebsiella pneumoniae. 54 61
17433752 2007
6
Test characteristics of C-reactive protein (CRP) for pediatric septic arthritis. 54 61
15105739 2004
7
Assessment of the test characteristics of C-reactive protein for septic arthritis in children. 54 61
12724603 2003
8
Acute septic arthritis of the hip in children in northern Australia. 54 61
12608977 2003
9
Evaluation of leukergy test as an indicator of infection in hip joint in children. 54 61
11218681 2000
10
The painful hip: evaluation of criteria for clinical decision-making. 54 61
10541950 1999
11
Bacterial or crystal-associated arthritis? Discriminating ability of serum inflammatory markers. 54 61
10225388 1998
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 54 61
8382334 1993
13
Bilateral End-Organ Endophthalmitis in Setting of Serratia marcescens Urosepsis on 18F-FDG PET/CT. 61
31876818 2020
14
The Osteoarticular Infection in a Pediatric Emergency Setting: A Challenging Diagnosis. 61
31895291 2020
15
Arthroscopic Treatment of Acute Septic Arthritis of the Hip Joint in Pediatric Patients Aged 10 Years or Younger. 61
31734041 2020
16
Pediatric Musculoskeletal Infections. 61
31779837 2020
17
Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway. 61
31431733 2020
18
Mycobacterium kansasii arthritis of the elbow in an immunocompetent patient with a suspected soft-tissue tumor. 61
31427201 2020
19
Geniculate Artery Embolization in Patients With Recurrent Hemarthrosis After Knee Arthroplasty: A Retrospective Study. 61
31601456 2020
20
Diagnosis and treatment of mycoplasmal septic arthritis: a systematic review. 61
31792575 2020
21
Lower incidence of post-operative septic arthritis following revision anterior cruciate ligament reconstruction with quadriceps tendon compared to hamstring tendons. 61
32020252 2020
22
Soaking of the graft in vancomycin dramatically reduces the incidence of postoperative septic arthritis after anterior cruciate ligament reconstruction. 61
32030505 2020
23
Impact of simultaneous neutralization of IL-17A and treatment with recombinant IL-2 on Th17-Treg cell population in S.aureus induced septic arthritis. 61
31790794 2020
24
The Masquelet technique for septic arthritis of the small joint in the hands: Case reports. 61
31890833 2020
25
Septic arthritis in a previously healthy man with pan-negative infectious and rheumatologic work-up. 61
32019756 2020
26
Repeat irrigation & debridement for patients with acute septic knee arthritis: Incidence and risk factors. 61
31992942 2020
27
Vancomycin-soaked autografts during ACL reconstruction reduce the risk of post-operative infection without affecting return to sport or knee function. 61
32025764 2020
28
Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review. 61
32008574 2020
29
Etoposide-mediated depletion of peripheral blood monocytes post s.aureus infection attenuates septic arthritis by modulating macrophage-derived factors responsible for inflammatory destruction. 61
32032616 2020
30
Fishing for a Diagnosis, the Impact of Delayed Diagnosis on the Course of Mycobacterium marinum Infection: 21 Years of Experience at a Tertiary Care Hospital. 61
31988976 2020
31
[Evaluation of the impact of the Spanish consensus document on the approach to osteoarticular infections in Spain through the Paediatrics Osteoarticular Infections Network (RIOPED)]. 61
31980415 2020
32
Determination of diagnostic value (validity) leukocyte esterase (urine dipstick strip) in differentiating inflammatory arthritis from bacterial arthritis. 61
31992368 2020
33
A Report of Antibiotic-Treated, Blood-Culture Negative MRSA Septic Arthritis of the Temporomandibular Joint Preceding MRSA Epidural Abscess. 61
31351042 2020
34
Septic arthritis of the lumbar facet joint. Case and literature review. 61
31843439 2020
35
Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. 61
31836615 2020
36
Rituximab-induced serum sickness in a 6-year-old boy with steroid-dependent nephrotic syndrome. 61
31970629 2020
37
Outbreaks of Kingella kingae Infections in Daycare Centers Suggest Tissue Tropism of the Causative Strains. 61
31925952 2020
38
Interleukin-1β and tumor necrosis factor are essential in controlling an experimental orthopedic implant-associated infection. 61
31975434 2020
39
Septic arthritis and acute kidney injury: questions. 61
31897712 2020
40
Septic arthritis and acute kidney injury: answers. 61
31897713 2020
41
Septic arthritis: A case report. 61
31948708 2020
42
Endogenous endophthalmitis secondary to septic arthritis caused by group A Streptococcus infection: A case report and literature review. 61
31300376 2020
43
Secondary purulent infections of the elbow joint: a retrospective, single-center study. 61
31954400 2020
44
Bacterial Septic Arthritis of the Adult Native Knee Joint: A Review. 61
31899698 2020
45
Epidemiology, Management, and Outcomes of Large and Small Native Joint Septic Arthritis in Adults. 61
30941403 2020
46
Clinical characteristics and outcomes of patients with septic arthritis treated without surgery. 61
31898794 2020
47
Point-of-Care Ultrasound for the Detection of Hip Effusion and Septic Arthritis in Adult Patients With Hip Pain and Negative Initial Imaging. 61
31982198 2020
48
Total Hip Arthroplasty With Subtrochanteric Shortening Osteotomy in Patients With High Hip Dislocation Secondary to Childhood Septic Arthritis: A Matched Comparative Study With Crowe IV Developmental Dysplasia. 61
31521447 2020
49
Re: Kang et al. Wrist inflammation: a retrospective comparison between septic and non-septic arthritis. J Hand Surg Eur. 2018, 43: 431-7. 61
31510856 2020
50
Septic arthritis of the lumbar facet joint presenting as spontaneous bacterial peritonitis: a rare case requiring surgical intervention. 61
31463672 2020

Variations for Septic Arthritis

Expression for Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for Septic Arthritis

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
2
Show member pathways
13.39 MMP7 MMP3 MMP2 MMP1 ITGA2 CXCR3
3
Show member pathways
13.37 TLR9 TLR5 TLR4 TLR3 TLR2 ITGA2
4
Show member pathways
13.2 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
5
Show member pathways
13.1 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
6 12.82 MMP2 MMP1 ITGA2 IFNG CXCL8
7
Show member pathways
12.81 TLR9 TLR4 TLR3 TLR2 IFNG CXCL8
8
Show member pathways
12.73 MMP7 MMP3 MMP2 MMP1 ITGA2
9
Show member pathways
12.69 TLR9 TLR5 TLR4 TLR3 TLR2
10
Show member pathways
12.6 TLR9 TLR4 TLR2 PPP3CA IFNG
11
Show member pathways
12.59 TLR5 TLR4 TLR2 PPP3CA IFNG
12
Show member pathways
12.58 TLR9 TLR5 TLR4 TLR3 TLR2 PPP3CA
13 12.56 TLR9 TLR3 TLR2 PPP3CA IFNG
14
Show member pathways
12.42 TLR9 TLR5 TLR4 TLR3 TLR2
15
Show member pathways
12.32 CXCR3 CXCL8 CXCL11 CCL18
16
Show member pathways
12.29 TLR4 TLR3 IFNG CXCL8
17 12.29 TLR4 TLR2 MMP2 ITGA2
18
Show member pathways
12.25 TLR9 TLR5 TLR4 TLR3 TLR2 CXCL8
19 12.23 TLR9 TLR4 TLR2 PPP3CA IFNG
20
Show member pathways
12.2 TLR5 TLR2 MMP3 MMP1 IFNG DEFB4A
21
Show member pathways
12.03 TLR9 TLR5 TLR4 TLR3 TLR2
22
Show member pathways
12.02 TLR9 TLR5 TLR4 TLR3 TLR2 IFNG
23 12.01 TLR4 PPP3CA IFNG CXCL8
24 11.98 MMP3 MMP2 MMP1 CXCL8
25
Show member pathways
11.98 TLR4 TLR2 MMP7 MMP3 MMP2 IFNG
26 11.93 TLR4 TLR2 IFNG CXCL8
27
Show member pathways
11.91 MMP7 MMP3 MMP2 MMP1
28 11.82 MMP7 MMP3 MMP2
29 11.8 TLR5 TLR4 IFNG CXCL8
30 11.78 MMP1 IFNG CXCL8
31
Show member pathways
11.78 TLR9 TLR5 TLR4 TLR2 IFNG DEFB4A
32 11.74 MMP3 IFNG CXCL11 CCL18
33 11.72 MMP2 MMP1 CXCL8
34 11.7 TLR4 TLR2 MMP3 MMP1 IFNG CXCL8
35
Show member pathways
11.67 MMP3 MMP2 MMP1 IFNG CXCL8
36 11.65 MMP2 CXCL8 CALCA
37 11.64 MMP7 MMP3 MMP2 MMP1 CXCL8
38 11.61 TLR5 TLR4 TLR2 CXCL8
39 11.58 MMP2 IFNG CXCL8
40 11.56 TLR9 TLR5 TLR4 TLR3 TLR2 ITGA2
41 11.52 TLR4 TLR2 IFNG
42 11.49 TLR9 TLR5 TLR4 TLR3 TLR2 MMP7
43 11.47 TLR9 TLR4 TLR2 IFNG CXCL8
44 11.35 MMP2 MMP1 CXCL8
45 11.33 MMP2 ITGA2 CXCL8

GO Terms for Septic Arthritis

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 TLR4 TLR3 TLR2 MMP7 ITGA2 CXCR3
2 extracellular space GO:0005615 9.7 TLR3 MMP7 MMP3 MMP2 IFNG DEFB4A
3 extracellular matrix GO:0031012 9.55 TLR3 MMP7 MMP3 MMP2 MMP1
4 extracellular region GO:0005576 9.44 TREM1 TLR9 MMP7 MMP3 MMP2 MMP1

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.34 TLR9 TLR5 TLR4 TLR3 TLR2 CXCR3
2 innate immune response GO:0045087 10.14 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
3 positive regulation of gene expression GO:0010628 10.1 TLR9 TLR4 TLR3 TLR2 PPP3CA IFNG
4 defense response to bacterium GO:0042742 10.06 TLR9 TLR5 TLR4 TLR3 DEFB4A
5 extracellular matrix organization GO:0030198 10.03 MMP7 MMP3 MMP2 MMP1 ITGA2
6 chemotaxis GO:0006935 10 DEFB4A CXCR3 CXCL8 CXCL11 CCL18
7 cellular response to lipopolysaccharide GO:0071222 9.99 TLR5 TLR4 CXCL8 CXCL11
8 defense response GO:0006952 9.98 TLR3 DEFB4A CXCL8 CXCL11
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TLR9 TLR4 TLR3 TLR2
10 immune response GO:0006955 9.97 TLR9 TLR4 TLR2 IFNG DEFB4A CXCR3
11 cellular response to interferon-gamma GO:0071346 9.94 TLR4 TLR3 TLR2 CCL18
12 chemokine-mediated signaling pathway GO:0070098 9.92 CXCR3 CXCL8 CXCL11 CCL18
13 extracellular matrix disassembly GO:0022617 9.92 MMP7 MMP3 MMP2 MMP1
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TLR9 TLR4 TLR3 TLR2
15 positive regulation of interleukin-6 production GO:0032755 9.91 TLR9 TLR4 TLR3 TLR2
16 positive regulation of inflammatory response GO:0050729 9.91 TLR9 TLR4 TLR3 TLR2 ITGA2
17 defense response to Gram-negative bacterium GO:0050829 9.89 TLR9 TLR4 DEFB4A
18 positive regulation of JNK cascade GO:0046330 9.89 TLR9 TLR4 TLR3
19 neutrophil chemotaxis GO:0030593 9.89 CXCL8 CXCL11 CCL18
20 calcium-mediated signaling GO:0019722 9.88 PPP3CA CXCR3 CXCL8
21 cellular response to mechanical stimulus GO:0071260 9.88 TLR5 TLR4 TLR3 MMP7 ITGA2
22 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.87 DEFB4A CXCL8 CXCL11
23 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 TLR9 TLR4 TLR3
24 positive regulation of tumor necrosis factor production GO:0032760 9.87 TLR9 TLR4 TLR3 TLR2
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TLR5 TLR4 IFNG
26 collagen catabolic process GO:0030574 9.85 MMP7 MMP3 MMP2 MMP1
27 positive regulation of protein complex assembly GO:0031334 9.84 MMP3 MMP1 IFNG
28 microglial cell activation GO:0001774 9.84 TLR3 TLR2 IFNG
29 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.83 TLR9 TLR5 TLR4 TLR2
30 positive regulation of interleukin-10 production GO:0032733 9.81 TLR9 TLR4 TLR2
31 negative regulation of osteoclast differentiation GO:0045671 9.81 TLR4 TLR3 CALCA
32 positive regulation of interferon-beta production GO:0032728 9.8 TLR9 TLR4 TLR3 TLR2
33 toll-like receptor signaling pathway GO:0002224 9.77 TLR9 TLR5 TLR4 TLR3 TLR2
34 regulation of cytokine secretion GO:0050707 9.76 TLR9 TLR5 TLR2
35 positive regulation of chemokine production GO:0032722 9.76 TLR9 TLR4 TLR3 TLR2
36 response to molecule of bacterial origin GO:0002237 9.75 TLR9 TLR2 CXCL8
37 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR9 TLR4 TLR2 IFNG
38 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.72 TLR9 TLR4
39 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.72 TLR9 TLR3
40 T cell chemotaxis GO:0010818 9.71 CXCR3 CXCL11
41 positive regulation of chemokine biosynthetic process GO:0045080 9.71 TLR3 IFNG
42 positive regulation of interferon-beta biosynthetic process GO:0045359 9.71 TLR9 TLR4 TLR3
43 I-kappaB phosphorylation GO:0007252 9.71 TLR9 TLR4 TLR3 TLR2
44 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
45 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 TLR4 IFNG
46 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.69 TLR4 TLR3
47 positive regulation of interleukin-18 production GO:0032741 9.68 TLR9 TLR2
48 tumor necrosis factor production GO:0032640 9.68 TLR9 TLR2
49 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.67 TLR9 TLR3
50 positive regulation of matrix metallopeptidase secretion GO:1904466 9.65 TLR4 TLR2

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 TLR9 TLR5 TLR4 TLR3 TLR2 PPP3CA
2 signaling receptor activity GO:0038023 9.73 TREM1 TLR4 TLR3 TLR2
3 transmembrane signaling receptor activity GO:0004888 9.71 TLR9 TLR5 TLR4 TLR3
4 amyloid-beta binding GO:0001540 9.63 TLR4 TLR2 ITGA2
5 metallopeptidase activity GO:0008237 9.56 MMP7 MMP3 MMP2 MMP1
6 chemokine activity GO:0008009 9.54 CXCL8 CXCL11 CCL18
7 signaling pattern recognition receptor activity GO:0008329 9.48 TLR9 TLR2
8 serine-type endopeptidase activity GO:0004252 9.46 MMP7 MMP3 MMP2 MMP1
9 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
10 metalloendopeptidase activity GO:0004222 8.92 MMP7 MMP3 MMP2 MMP1

Sources for Septic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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