MCID: SPT003
MIFTS: 23

Septic Myocarditis

Categories: Cardiovascular diseases

Aliases & Classifications for Septic Myocarditis

MalaCards integrated aliases for Septic Myocarditis:

Name: Septic Myocarditis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10779
ICD9CM 34 422.92
SNOMED-CT 67 64043005
ICD10 32 I40.0
UMLS 70 C0155690

Summaries for Septic Myocarditis

Disease Ontology : 12 An acute myocarditis that is characterized by an underlying infectious insult to the myocardium that induces acute inflammation.

MalaCards based summary : Septic Myocarditis is related to acute myocarditis and multicentric castleman disease. An important gene associated with Septic Myocarditis is CRYZ (Crystallin Zeta), and among its related pathways/superpathways are Development Ligand-independent activation of ESR1 and ESR2 and cGMP-PKG signaling pathway. Affiliated tissues include heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Septic Myocarditis

Diseases related to Septic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 acute myocarditis 10.0 TNNI3 IL10
2 multicentric castleman disease 10.0 IRF4 IL10
3 central nervous system hematologic cancer 9.9 IRF4 IL10
4 heart conduction disease 9.8 TNNI3 CAV3 ATP2A2
5 gingival disease 9.7 TIMP1 IL10
6 burkitt lymphoma 9.4 TIMP1 LDHA IRF4 IL10
7 pulmonary disease, chronic obstructive 9.2 TIMP1 MAPK14 IL10
8 dilated cardiomyopathy 9.1 TNNI3 TIMP1 MAPK14 IL10 ATP2A2

Comorbidity relations with Septic Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Septic Myocarditis:



Diseases related to Septic Myocarditis

Symptoms & Phenotypes for Septic Myocarditis

GenomeRNAi Phenotypes related to Septic Myocarditis according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.8 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.8 IRF4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.8 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.8 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.8 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.8 IRF4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.8 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-179 9.8 LDHA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.8 LDHA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.8 LDHA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.8 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.8 LDHA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.8 LDHA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.8 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-212 9.8 LDHA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.8 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.8 LDHA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.8 LDHA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-38 9.8 LDHA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.8 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.8 IRF4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-59 9.8 LDHA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.8 IL10
25 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.8 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.8 IL10 LDHA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.8 LDHA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.8 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.8 IL10

MGI Mouse Phenotypes related to Septic Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 ATP2A2 CAV3 GLIS3 IL10 IRF4 LDHA
2 cardiovascular system MP:0005385 9.87 ATP2A2 CAV3 IL10 LDHA MAPK14 TIMP1
3 immune system MP:0005387 9.76 ATP2A2 CAV3 IL10 IRF4 LDHA MAPK14
4 neoplasm MP:0002006 9.43 ATP2A2 IL10 IRF4 LDHA MAPK14 TIMP1
5 respiratory system MP:0005388 9.1 ATP2A2 IL10 LDHA MAPK14 TIMP1 TNNI3

Drugs & Therapeutics for Septic Myocarditis

Search Clinical Trials , NIH Clinical Center for Septic Myocarditis

Genetic Tests for Septic Myocarditis

Anatomical Context for Septic Myocarditis

MalaCards organs/tissues related to Septic Myocarditis:

40
Heart

Publications for Septic Myocarditis

Articles related to Septic Myocarditis:

# Title Authors PMID Year
1
Role of IRF4 in the Protection of Metformin-Mediated Sepsis Myocarditis. 61
30944551 2019
2
[Neisseria meningitidis pneumonia. A case report]. 61
29999162 2018
3
[Myocarditis in an autopsy cohort]. 61
2740878 1989

Variations for Septic Myocarditis

Expression for Septic Myocarditis

Search GEO for disease gene expression data for Septic Myocarditis.

Pathways for Septic Myocarditis

Pathways related to Septic Myocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 RPS6KA5 MAPK14 LDHA
2
Show member pathways
11.76 TNNI3 RPS6KA5 MAPK14 ATP2A2
3 11.39 TIMP1 IRF4 IL10
4 11.05 RPS6KA5 MAPK14
5 10.95 RPS6KA5 MAPK14
6 10.91 MAPK14 IL10
7
Show member pathways
10.75 RPS6KA5 MAPK14
8 10.6 MAPK14 IRF4 IL10

GO Terms for Septic Myocarditis

Biological processes related to Septic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 RPS6KA5 MAPK14 IRF4 IL10 GLIS3
2 response to lipopolysaccharide GO:0032496 9.54 MAPK14 IL10 ATP2A2
3 negative regulation of cytokine production GO:0001818 9.48 RPS6KA5 IL10
4 skeletal muscle contraction GO:0003009 9.43 TNNI3 ATP2A2
5 defense response to protozoan GO:0042832 9.4 IRF4 IL10
6 positive regulation of myotube differentiation GO:0010831 9.32 MAPK14 CAV3
7 T-tubule organization GO:0033292 9.26 CAV3 ATP2A2
8 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.16 CAV3 ATP2A2
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 8.96 TIMP1 IL10
10 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 8.62 TNNI3 ATP2A2

Sources for Septic Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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