MCID: SPT002
MIFTS: 41

Septicemic Plague

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Septicemic Plague

MalaCards integrated aliases for Septicemic Plague:

Name: Septicemic Plague 12 15
Plague, Septicemic 76 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3481
ICD10 33 A20.7
ICD9CM 35 020.2
MeSH 44 D010930
SNOMED-CT 68 9012003
UMLS 73 C0152936

Summaries for Septicemic Plague

Disease Ontology : 12 A plague that results in infection located in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has symptom fever, has symptom chills, has symptom prostration, has symptom abdominal pain, has symptom shock and has symptom bleeding into skin and other organs.

MalaCards based summary : Septicemic Plague, also known as plague, septicemic, is related to plague and bubonic plague, and has symptoms including fever, abdominal pain and chills. An important gene associated with Septicemic Plague is IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Streptomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and colon, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Septicemic plague is one of the three main forms of plague. It is caused by Yersinia pestis, a... more...

Related Diseases for Septicemic Plague

Graphical network of the top 20 diseases related to Septicemic Plague:



Diseases related to Septicemic Plague

Symptoms & Phenotypes for Septicemic Plague

Symptoms:

12
  • fever
  • abdominal pain
  • chills
  • shock
  • prostration
  • bleeding into skin

MGI Mouse Phenotypes related to Septicemic Plague:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 C4B CCNE1 CXCR2 IFNAR1 IFNB1 IL17A
2 homeostasis/metabolism MP:0005376 10.07 C4B CXCR2 IFNAR1 IFNB1 IL17A IRF3
3 cellular MP:0005384 10.02 CCNE1 CXCR2 IFNAR1 IRF3 MYD88 PLG
4 immune system MP:0005387 10.02 C4B CCNE1 CXCR2 IFNAR1 IFNB1 IL17A
5 digestive/alimentary MP:0005381 9.93 C4B CCNE1 IFNAR1 IL17A MYD88 PLG
6 endocrine/exocrine gland MP:0005379 9.91 CCNE1 CXCR2 IFNAR1 IL17A MYD88 PLG
7 mortality/aging MP:0010768 9.86 C4B CCNE1 CXCR2 IFNAR1 IL17A MYD88
8 neoplasm MP:0002006 9.63 CCNE1 CXCR2 IFNAR1 IFNB1 MYD88 PLG
9 renal/urinary system MP:0005367 9.5 C4B CXCR2 IFNAR1 IL17A MYD88 PLG
10 skeleton MP:0005390 9.1 CCNE1 CXCR2 IFNAR1 IFNB1 IL17A MYD88

Drugs & Therapeutics for Septicemic Plague

Drugs for Septicemic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gentamicins Phase 2, Phase 3
5
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
6
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
7 Antiparasitic Agents Phase 2
8 Antiprotozoal Agents Phase 2
9 Cytochrome P-450 Enzyme Inhibitors Phase 2
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
11 Antimalarials Phase 2
12 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Diagnosis of Plague Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline

Search NIH Clinical Center for Septicemic Plague

Genetic Tests for Septicemic Plague

Anatomical Context for Septicemic Plague

MalaCards organs/tissues related to Septicemic Plague:

41
Skin, Testes, Colon, Tongue

The Foundational Model of Anatomy Ontology organs/tissues related to Septicemic Plague:

19
Vasculature Where Bacterial Endotoxins Cause Coagulation

Publications for Septicemic Plague

Articles related to Septicemic Plague:

# Title Authors Year
1
A historical evaluation of Chinese tongue diagnosis in the treatment of septicemic plague in the pre-antibiotic era, and as a new direction for revolutionary clinical research applications. ( 29691189 )
2018
2
Bioluminescent tracking of colonization and clearance dynamics of plasmid-deficient Yersinia pestis strains in a mouse model of septicemic plague. ( 24333143 )
2013
3
Investigation of a researcher's death due to septicemic plague. ( 21714673 )
2011
4
Septicemic plague in a community hospital in California. ( 18541761 )
2008
5
Persistent Yersinia pestis antigens in ischemic tissues of a patient with septicemic plague. ( 16084958 )
2005
6
Septicemic plague in New Mexico. ( 3794395 )
1987
7
Septicemic plague in a 14-month-old child. ( 3945561 )
1986
8
Septicemic plague that mimics Reye's syndrome. ( 433859 )
1979

Variations for Septicemic Plague

Expression for Septicemic Plague

Search GEO for disease gene expression data for Septicemic Plague.

Pathways for Septicemic Plague

Pathways related to Septicemic Plague according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 C4B CXCR2 IFNAR1 IFNB1 IL17A IRF3
2
Show member pathways
13.08 IFNAR1 IFNB1 IL17A IRF3 MYD88
3
Show member pathways
12.71 IFNAR1 IFNB1 IRF3 MYD88 TLR7
4
Show member pathways
12.64 CCNE1 IFNAR1 IFNB1 IRF3 VTN
5
Show member pathways
12.52 CCNE1 CXCR2 IFNAR1 IFNB1 IRF3 MYD88
6
Show member pathways
12.37 IRF3 MYD88 TLR7 VTN
7 12.29 IL17A IRF3 MYD88 TLR7
8
Show member pathways
12.11 IRF3 MYD88 TLR7 VTN
9
Show member pathways
12.01 IFNAR1 IFNB1 IL17A IRF3
10
Show member pathways
11.95 IFNB1 MYD88 TLR7
11 11.87 C4B PLG VTN
12
Show member pathways
11.86 CCNE1 IFNAR1 IFNB1 IRF3 MYD88 PLG
13
Show member pathways
11.84 IFNB1 IRF3 MYD88 TLR7
14 11.8 IFNAR1 IFNB1 IRF3
15 11.66 CCNE1 IFNAR1 IFNB1 IRF3 MYD88
16 11.43 C4B IRF3 MYD88
17 11.27 PLG VTN
18
Show member pathways
10.93 IFNAR1 IRF3
19 10.73 IFNAR1 IFNB1

GO Terms for Septicemic Plague

Cellular components related to Septicemic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 C4B PLG VTN

Biological processes related to Septicemic Plague according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.84 C4B IRF3 MYD88 TLR7
2 innate immune response GO:0045087 9.8 C4B IRF3 MYD88 TLR7
3 immune response GO:0006955 9.78 CXCR2 IL17A TLR7 VTN
4 cell surface receptor signaling pathway GO:0007166 9.77 CXCR2 IFNB1 MYD88
5 defense response to virus GO:0051607 9.69 IFNB1 IRF3 TLR7
6 response to lipopolysaccharide GO:0032496 9.63 IFNAR1 IRF3 MYD88
7 cytokine-mediated signaling pathway GO:0019221 9.62 IFNAR1 IFNB1 IL17A MYD88
8 toll-like receptor signaling pathway GO:0002224 9.58 MYD88 TLR7
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 IRF3 MYD88
10 positive regulation of type I interferon production GO:0032481 9.57 IRF3 MYD88
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.56 MYD88 TLR7
12 response to exogenous dsRNA GO:0043330 9.55 IFNB1 IRF3
13 response to virus GO:0009615 9.54 IFNAR1 IFNB1 MYD88
14 positive regulation of interleukin-8 production GO:0032757 9.52 MYD88 TLR7
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.43 IL17A MYD88
16 toll-like receptor 9 signaling pathway GO:0034162 9.4 MYD88 TLR7
17 inflammatory response GO:0006954 9.35 C4B CXCR2 IL17A MYD88 TLR7
18 positive regulation of interleukin-23 production GO:0032747 9.26 IL17A MYD88
19 type I interferon biosynthetic process GO:0045351 9.16 IRF3 MYD88
20 type I interferon signaling pathway GO:0060337 8.92 IFNAR1 IFNB1 IRF3 MYD88

Sources for Septicemic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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