MCID: SPT002
MIFTS: 31

Septicemic Plague

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases

Aliases & Classifications for Septicemic Plague

MalaCards integrated aliases for Septicemic Plague:

Name: Septicemic Plague 12 15 17
Plague, Septicemic 73 70

Classifications:



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Disease Ontology 12 DOID:3481
ICD9CM 34 020.2
MeSH 44 D010930
SNOMED-CT 67 9012003
ICD10 32 A20.7
UMLS 70 C0152936

Summaries for Septicemic Plague

Disease Ontology : 12 A plague that results in infection located in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has symptom fever, has symptom chills, has symptom prostration, has symptom abdominal pain, has symptom shock and has symptom bleeding into skin and other organs.

MalaCards based summary : Septicemic Plague, also known as plague, septicemic, is related to plague and pneumonic plague, and has symptoms including fever, abdominal pain and chills. An important gene associated with Septicemic Plague is VCAN (Versican), and among its related pathways/superpathways are Cell adhesion_ECM remodeling and Cell adhesion_Cell-matrix glycoconjugates. The drugs Streptomycin and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include vasculature where bacterial endotoxins cause coagulation, lymph node and spleen.

Wikipedia : 73 Septicemic plague is one of the three main forms of plague. It is caused by Yersinia pestis, a... more...

Related Diseases for Septicemic Plague

Graphical network of the top 20 diseases related to Septicemic Plague:



Diseases related to Septicemic Plague

Symptoms & Phenotypes for Septicemic Plague

Symptoms:

12
  • fever
  • abdominal pain
  • chills
  • shock
  • prostration
  • bleeding into skin

Drugs & Therapeutics for Septicemic Plague

Drugs for Septicemic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Gentamicins Phase 2, Phase 3
3 Anti-Bacterial Agents Phase 2, Phase 3
4 Anti-Infective Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Gentamicin Versus Streptomycin for the Treatment of Naturally Occurring Human Plague and Evaluation of Rapid Diagnostic Test Kits for Yersinia Pestis Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin

Search NIH Clinical Center for Septicemic Plague

Genetic Tests for Septicemic Plague

Anatomical Context for Septicemic Plague

The Foundational Model of Anatomy Ontology organs/tissues related to Septicemic Plague:

19
Vasculature Where Bacterial Endotoxins Cause Coagulation

MalaCards organs/tissues related to Septicemic Plague:

40
Lymph Node, Spleen, Nk Cells, Tongue, Neutrophil

Publications for Septicemic Plague

Articles related to Septicemic Plague:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Comparison of the transmission efficiency and plague progression dynamics associated with two mechanisms by which fleas transmit Yersinia pestis. 61
33284863 2020
2
Invasiveness of the Yersinia pestis ail protein contributes to host dissemination in pneumonic and oral plague. 61
31988008 2020
3
Difference in Strain Pathogenicity of Septicemic Yersinia pestis Infection in a TLR2-/- Mouse Model. 61
31907194 2020
4
[Rapidly fatal septicemic plague secondary to undiagnosed primary bubonic plague: case report]. 61
31800948 2019
5
Yersinia pestis Exploits Early Activation of MyD88 for Growth in the Lungs during Pneumonic Plague. 61
30642901 2019
6
Shift from primary pneumonic to secondary septicemic plague by decreasing the volume of intranasal challenge with Yersinia pestis in the murine model. 61
31121001 2019
7
Ail provides multiple mechanisms of serum resistance to Yersinia pestis. 61
30260060 2019
8
[The plague: An overview and hot topics]. 61
29628173 2018
9
A historical evaluation of Chinese tongue diagnosis in the treatment of septicemic plague in the pre-antibiotic era, and as a new direction for revolutionary clinical research applications. 61
29691189 2018
10
Reemergence of human plague in Yunnan, China in 2016. 61
29897940 2018
11
Induction of Type I Interferon through a Noncanonical Toll-Like Receptor 7 Pathway during Yersinia pestis Infection. 61
28847850 2017
12
Unique Case of Disseminated Plague With Multifocal Osteomyelitis. 61
28379405 2017
13
Plague in China 2014-All sporadic case report of pneumonic plague. 61
26895880 2016
14
Plague: Clinics, Diagnosis and Treatment. 61
27722868 2016
15
The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis. 61
25891079 2015
16
Bioluminescent tracking of colonization and clearance dynamics of plasmid-deficient Yersinia pestis strains in a mouse model of septicemic plague. 61
24333143 2014
17
Plague: history and contemporary analysis. 61
23041039 2013
18
YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. 61
24358292 2013
19
Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. 61
22911267 2012
20
Yersiniabactin iron uptake: mechanisms and role in Yersinia pestis pathogenesis. 61
21609780 2011
21
Investigation of a researcher's death due to septicemic plague. 61
21714673 2011
22
Novel genetic tools for diaminopimelic acid selection in virulence studies of Yersinia pestis. 61
21399698 2011
23
Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague. 61
21356370 2011
24
Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague. 61
20876291 2010
25
Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plague. 61
21179420 2010
26
YopR impacts type III needle polymerization in Yersinia species. 61
19968786 2010
27
Septicemic plague in a community hospital in California. 61
18541761 2008
28
Preliminary validation of real-time PCR assays for the identification of Yersinia pestis. 61
18783342 2008
29
Human plague--four states, 2006. 61
16943764 2006
30
Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague. 61
16567636 2006
31
Persistent Yersinia pestis antigens in ischemic tissues of a patient with septicemic plague. 61
16084958 2005
32
The plague virulence protein YopM targets the innate immune response by causing a global depletion of NK cells. 61
15271919 2004
33
Plague. 61
15207311 2004
34
A case of plague successfully treated with ciprofloxacin and sympathetic blockade for treatment of gangrene. 61
12567312 2003
35
[Yersinia pestis as a dangerous biological weapon]. 61
12474416 2002
36
Histopathology of experimental plague in cats. 61
11280372 2001
37
Cases of cat-associated human plague in the Western US, 1977-1998. 61
10852811 2000
38
[Pulmonic plague]. 61
10100351 1998
39
Detection of 400-year-old Yersinia pestis DNA in human dental pulp: an approach to the diagnosis of ancient septicemia. 61
9770538 1998
40
Fatal human plague--Arizona and Colorado, 1996. 61
9218646 1997
41
Plague pneumonia disease caused by Yersinia pestis. 61
9097371 1997
42
Reported cases of human plague infections in the United States, 1970-1991. 61
8395603 1993
43
Plague. A clinical review of 27 cases. 61
1599354 1992
44
A. Conan Doyle, Sherlock Holmes, and murder by tropical infection. 61
3547575 1987
45
Septicemic plague in New Mexico. 61
3794395 1987
46
Septicemic plague in a 14-month-old child. 61
3945561 1986
47
Pediatric plague. 61
7079041 1982
48
Recommendations for the control of Yersinia pestis infections. Recommendations from the CDC. 61
6904395 1980
49
Septicemic plague that mimics Reye's syndrome. 61
433859 1979
50
Epidemiologic and clinical features of an outbreak of bubonic plague in New Mexico. 61
908848 1977

Variations for Septicemic Plague

Expression for Septicemic Plague

Search GEO for disease gene expression data for Septicemic Plague.

Pathways for Septicemic Plague

Pathways related to Septicemic Plague according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.94 VCAN PLG
2 10.55 VCAN PLG
3 9.74 SERPINF2 PLG

GO Terms for Septicemic Plague

Cellular components related to Septicemic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.26 WNT2 VCAN SERPINF2 PLG
2 platelet alpha granule lumen GO:0031093 9.16 SERPINF2 PLG
3 extrinsic component of external side of plasma membrane GO:0031232 8.62 WNT2 PLG

Biological processes related to Septicemic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 COPII vesicle coating GO:0048208 9.16 RAB1B CNIH1
2 fibrinolysis GO:0042730 8.96 SERPINF2 PLG
3 negative regulation of fibrinolysis GO:0051918 8.62 SERPINF2 PLG

Sources for Septicemic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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