MCID: SRT004
MIFTS: 49

Serotonin Syndrome

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Serotonin Syndrome

MalaCards integrated aliases for Serotonin Syndrome:

Name: Serotonin Syndrome 59 55
Malignant Carcinoid Syndrome 73
Serotonergic Syndrome 59
Serotonin Toxidrome 59
Serotonin Toxicity 59
Serotonin Storm 59

Characteristics:

Orphanet epidemiological data:

59
serotonin syndrome
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA43116
MESH via Orphanet 45 D020230
UMLS via Orphanet 74 C0699828
UMLS 73 C0024586

Summaries for Serotonin Syndrome

MalaCards based summary : Serotonin Syndrome, also known as malignant carcinoid syndrome, is related to depression and fibromyalgia. An important gene associated with Serotonin Syndrome is HTR3A (5-Hydroxytryptamine Receptor 3A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Serotonergic synapse. Affiliated tissues include brain, spinal cord and liver, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic... more...

Related Diseases for Serotonin Syndrome

Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 depression 30.2 HTR1A HTR2A MAOA SLC6A4
2 fibromyalgia 29.9 HTR2A HTR3A SLC6A4
3 parkinson disease, late-onset 29.7 CYP2D6 HTR1A HTR2A MAOA MAOB SLC6A4
4 post-traumatic stress disorder 29.6 HTR2A MAOA MAOB SLC6A4
5 obsessive-compulsive disorder 29.3 CYP2D6 HTR1A HTR2A HTR3A MAOA OXT
6 anxiety 29.1 CYP2D6 CYP3A4 HTR1A HTR2A HTR3A MAOA
7 small cell cancer of the lung 29.0 CHGA GAST SST
8 schizoid personality disorder 10.3 HTR1A HTR2A
9 hypoactive sexual desire disorder 10.3 HTR1A HTR2A
10 neuroleptic malignant syndrome 10.3
11 substance-induced psychosis 10.3 HTR1A HTR2A
12 avoidant personality disorder 10.2 MAOA SLC6A4
13 rumination disorder 10.2 HTR1A HTR3A
14 phobic disorder 10.2 HTR1A MAOA SLC6A4
15 psychosexual disorder 10.2 HTR1A HTR2A SLC6A4
16 premature ejaculation 10.2 HTR1A HTR3A SLC6A4
17 dysthymic disorder 10.2 HTR2A MAOA SLC6A4
18 agoraphobia 10.2 HTR1A MAOA SLC6A4
19 periodic limb movement disorder 10.2 HTR1A HTR2A SLC6A4
20 dependent personality disorder 10.2 CYP3A4 MAOA MAOB
21 adenoma of the pancreas 10.2 CHGA SST
22 paranoid schizophrenia 10.2 HTR2A MAOA SLC6A4
23 antisocial personality disorder 10.2 MAOA MAOB SLC6A4
24 sexual disorder 10.2 HTR1A OXT SLC6A4
25 bipolar i disorder 10.2 HTR1A HTR2A SLC6A4
26 paraphilia disorder 10.2 MAOA MAOB OXT
27 substance abuse 10.2 CYP2D6 MAOA SLC6A4
28 postpartum depression 10.2 MAOA OXT SLC6A4
29 tobacco addiction 10.2 HTR2A MAOA SLC6A4
30 substance dependence 10.2 CYP2D6 MAOA SLC6A4
31 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
32 social phobia 10.2 HTR1A HTR3A MAOA SLC6A4
33 hemangioma of liver 10.2 CYP3A4 IFNA2
34 intestinal neuroendocrine benign tumor 10.2 MEN1 SSTR1
35 atypical depressive disorder 10.2 HTR2A MAOA MAOB SLC6A4
36 borderline personality disorder 10.2 HTR1A HTR2A MAOA SLC6A4
37 personality disorder 10.2 HTR1A HTR2A MAOA SLC6A4
38 endogenous depression 10.2 HTR1A HTR2A MAOA SLC6A4
39 pathological gambling 10.2 HTR2A MAOA MAOB SLC6A4
40 chronic fatigue syndrome 10.2 HTR1A HTR2A MAOA SLC6A4
41 kleptomania 10.2 CYP3A4 HTR1A MAOA SLC6A4
42 autoimmune atrophic gastritis 10.1 CHGA GAST
43 dyspepsia 10.1 HTR1A HTR3A SLC6A4 SST
44 postgastrectomy syndrome 10.1 PYY SST
45 pancreatic somatostatinoma 10.1 MEN1 SST
46 pituitary carcinoma 10.1 CHGA SST
47 motion sickness 10.1 HTR1A HTR3A TAC1
48 pylorospasm 10.1 GAST SST
49 glucagonoma 10.1 CHGA GHRH SST
50 small intestine neuroendocrine neoplasm 10.1 MEN1 SSTR1

Comorbidity relations with Serotonin Syndrome via Phenotypic Disease Network (PDN):


Intestinal Obstruction

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to Serotonin Syndrome

Symptoms & Phenotypes for Serotonin Syndrome

GenomeRNAi Phenotypes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.26 MAOA MEN1
2 Decreased viability GR00240-S-1 10.26 SST
3 Decreased viability GR00381-A-1 10.26 CYP2D6 HTR1A HTR3A PYY SLC6A4
4 Decreased viability GR00381-A-3 10.26 HTR1A HTR3A SLC6A4
5 Decreased viability GR00402-S-2 10.26 CGB3 CHGA CYP2D6 CYP3A4 GAST GHRH
6 no effect GR00402-S-1 9.62 CGB3 CHGA CYP2D6 CYP3A4 GAST GHRH

MGI Mouse Phenotypes related to Serotonin Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 HTR1A HTR2A HTR3A MAOA MAOB OXT
2 endocrine/exocrine gland MP:0005379 9.81 CHGA GAST GHRH HTR2A HTR3A MEN1
3 homeostasis/metabolism MP:0005376 9.8 CHGA GAST GHRH HTR1A HTR3A MAOA
4 nervous system MP:0003631 9.44 CHGA GHRH HTR1A HTR3A MAOA MAOB

Drugs & Therapeutics for Serotonin Syndrome

Search Clinical Trials , NIH Clinical Center for Serotonin Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Serotonin Syndrome

Anatomical Context for Serotonin Syndrome

MalaCards organs/tissues related to Serotonin Syndrome:

41
Brain, Spinal Cord, Liver, Lung, Pituitary, Thyroid, Small Intestine

Publications for Serotonin Syndrome

Articles related to Serotonin Syndrome:

(show top 50) (show all 670)
# Title Authors Year
1
Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. ( 29482205 )
2018
2
Serotonin Syndrome in Obstetrics: A Case Report and Review of Management. ( 29901770 )
2018
3
Serotonin, Syndrome ( 29493999 )
2018
4
Serotonin syndrome during a heat wave. ( 29437313 )
2018
5
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( 29795058 )
2018
6
Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome. ( 29210063 )
2018
7
Fentanyl-Associated Serotonin Syndrome and Chest Wall Rigidity in an Intensive Care Unit Patient. ( 29965805 )
2018
8
Severe Serotonin Syndrome in an Autistic New Psychoactive Substance User After Consumption of Pills Containing Methoxphenidine and I+-Methyltryptamine. ( 29210865 )
2018
9
Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. ( 29872601 )
2018
10
Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. ( 29752906 )
2018
11
Serotonin syndrome versus neuroleptic malignant syndrome: a case report. ( 29616715 )
2018
12
A Mixed Presentation of Serotonin Syndrome vs Neuroleptic Malignant Syndrome in a 12-Year-Old Boy. ( 29698346 )
2018
13
Implications of Off-Target Serotoninergic Drug Activity - An Analysis of Serotonin Syndrome Reports using a Systematic Bioinformatics Approach. ( 29972695 )
2018
14
Serotonin Syndrome Following Septal Myectomy in Association With Fentanyl and Methylene Blue: A Case Report. ( 29571985 )
2018
15
Conservative management of severe serotonin syndrome with coma, myoclonus, and crossed-extensor reflex complicated by hepatic encephalopathy. ( 29686575 )
2018
16
Diaphoresis: A Presentation of Serotonin Syndrome From Vortioxetine. ( 29917334 )
2018
17
Association Between Serotonin Syndrome and Second-Generation Antipsychotics via Pharmacological Target-Adverse Event Analysis. ( 29575568 )
2018
18
The role of chronic nutritional supplements consumption in a fulminant serotonin syndrome due to citalopram intoxication. ( 29317102 )
2018
19
Neuroleptic malignant syndrome and serotonin syndrome. ( 30459031 )
2018
20
Use of methylene blue in hepatic arterial infusion pump resulting in serotonin syndrome. A case report. ( 29984362 )
2018
21
Serotonin Syndrome in the Perioperative Setting. ( 30008467 )
2018
22
Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis. ( 30056864 )
2018
23
Serotonin Syndrome Masquerading as Ventricular Tachycardia Storm. ( 30077498 )
2018
24
Serotonin Toxicity and Urinary Analgesics: A Case Report and Systematic Literature Review of Methylene Blue-Induced Serotonin Syndrome. ( 30104021 )
2018
25
The scoop on serotonin syndrome. ( 30237838 )
2018
26
Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis. ( 30301727 )
2018
27
Is There Always a Right or Wrong?: Comments on the FDA Warnings About Triptans and the Serotonin Syndrome. ( 30303862 )
2018
28
Demystifying serotonin syndrome (or serotonin toxicity). ( 30315014 )
2018
29
Case of Serotonin Syndrome Initially Presenting as Diffuse Body Pain. ( 30318504 )
2018
30
Comment on Gressler et al.: Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research. ( 30380966 )
2018
31
Tramadol: Distinguishing the Pathophysiology of Serotonin Syndrome and Seizures. ( 30392647 )
2018
32
Serotonin Syndrome and Hippocampal Infarction. ( 30420109 )
2018
33
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome. ( 28667541 )
2017
34
Metoclopramide-induced Serotonin Syndrome. ( 28321081 )
2017
35
Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome. ( 29134498 )
2017
36
Malignant Syndrome and Serotonin Syndrome in a General Hospital Setting: Clinical Features, Frequency and Prognosis. ( 28943544 )
2017
37
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome. ( 28057811 )
2017
38
Controversies in Serotonin Syndrome Diagnosis and Management: A Review. ( 29207768 )
2017
39
Methylene blue-induced serotonin syndrome after left ventricular assist device implantation: A case report and literature review. ( 28655448 )
2017
40
A review of vilazodone exposures with focus on serotonin syndrome effects. ( 28594246 )
2017
41
Comment on Tapentadol and Serotonin Syndrome. ( 28515499 )
2017
42
Comment on "Probable Tapentadol-Associated Serotonin Syndrome After Overdose". ( 28515500 )
2017
43
Staying Topical: An Unusual Case of Serotonin Syndrome. ( 28806389 )
2017
44
Serotonin syndrome caused by drug to drug interaction between escitalopram and dextromethorphan. ( 28784915 )
2017
45
Serotonin Syndrome from 5-Hydroxytryptophan Supplement Ingestion in a 9-Month-Old Labrador Retriever. ( 28210931 )
2017
46
Codeine Precipitating Serotonin Syndrome in a Patient in Therapy with Antidepressant and Triptan. ( 28783942 )
2017
47
Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research. ( 29336654 )
2017
48
Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency. ( 29169770 )
2017
49
Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report. ( 28367296 )
2017
50
To the Editor: Serotonin syndrome. ( 28530902 )
2017

Variations for Serotonin Syndrome

Expression for Serotonin Syndrome

Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for Serotonin Syndrome

Pathways related to Serotonin Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 GHRH HTR1A HTR2A OXT PYY SST
2 11.56 CYP2D6 HTR1A HTR2A HTR3A MAOA MAOB
3 11.44 HTR1A HTR2A HTR3A MAOA SLC6A4 SST
4
Show member pathways
11.36 CYP2D6 CYP3A4 SLC6A4
5 11 HTR1A HTR2A HTR3A MAOA SLC6A4
6
Show member pathways
10.63 MAOA MAOB
7
Show member pathways
10.61 CYP2D6 CYP3A4 HTR3A
8 10.58 MAOA MAOB
9
Show member pathways
10.52 MAOA MAOB

GO Terms for Serotonin Syndrome

Cellular components related to Serotonin Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CGB3 CHGA GAST GHRH IFNA2 OXT
2 integral component of presynaptic membrane GO:0099056 9.43 HTR2A HTR3A SLC6A4
3 integral component of postsynaptic membrane GO:0099055 9.33 HTR2A HTR3A SLC6A4
4 extracellular region GO:0005576 9.32 CGB3 CHGA GAST GHRH IFNA2 NOTCH1

Biological processes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.93 HTR2A MAOB SLC6A4 SST
2 G protein-coupled receptor signaling pathway GO:0007186 9.81 GAST GHRH HTR1A HTR2A OXT PYY
3 neuropeptide signaling pathway GO:0007218 9.79 PYY SSTR1 TAC1
4 chemical synaptic transmission GO:0007268 9.77 HTR1A HTR2A HTR3A SST TAC1
5 memory GO:0007613 9.76 HTR2A OXT SLC6A4
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 GHRH HTR2A OXT TAC1
7 cell-cell signaling GO:0007267 9.72 CGB3 GHRH IFNA2 SST TAC1
8 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.71 HTR1A HTR2A SSTR1
9 negative regulation of cell-substrate adhesion GO:0010812 9.62 MEN1 NOTCH1
10 vasoconstriction GO:0042310 9.62 HTR1A SLC6A4
11 positive regulation of ossification GO:0045778 9.61 OXT TAC1
12 positive regulation of renal sodium excretion GO:0035815 9.6 OXT TAC1
13 sleep GO:0030431 9.59 HTR2A OXT
14 neurotransmitter catabolic process GO:0042135 9.58 MAOA MAOB
15 response to steroid hormone GO:0048545 9.58 MAOB OXT SST
16 behavior GO:0007610 9.57 HTR1A HTR2A
17 oxidative demethylation GO:0070989 9.56 CYP2D6 CYP3A4
18 dopamine catabolic process GO:0042420 9.55 MAOA MAOB
19 heterocycle metabolic process GO:0046483 9.52 CYP2D6 CYP3A4
20 drug catabolic process GO:0042737 9.51 CYP2D6 CYP3A4
21 monoterpenoid metabolic process GO:0016098 9.49 CYP2D6 CYP3A4
22 sperm ejaculation GO:0042713 9.48 OXT SLC6A4
23 alkaloid catabolic process GO:0009822 9.43 CYP2D6 CYP3A4
24 response to food GO:0032094 9.43 GAST GHRH OXT
25 regulation of signaling receptor activity GO:0010469 9.17 CGB3 GAST GHRH IFNA2 OXT PYY
26 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR3A

Molecular functions related to Serotonin Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CGB3 GAST GHRH OXT PYY SST
2 neuropeptide hormone activity GO:0005184 9.33 GHRH OXT PYY
3 primary amine oxidase activity GO:0008131 9.26 MAOA MAOB
4 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR3A SLC6A4

Sources for Serotonin Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....