MCID: SRT004
MIFTS: 45

Serotonin Syndrome

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Serotonin Syndrome

MalaCards integrated aliases for Serotonin Syndrome:

Name: Serotonin Syndrome 60 56 17
Malignant Carcinoid Syndrome 74
Serotonergic Syndrome 60
Serotonin Toxidrome 60
Serotonin Toxicity 60
Serotonin Storm 60

Characteristics:

Orphanet epidemiological data:

60
serotonin syndrome
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

MESH via Orphanet 46 D020230
UMLS via Orphanet 75 C0699828
Orphanet 60 ORPHA43116
UMLS 74 C0024586

Summaries for Serotonin Syndrome

MalaCards based summary : Serotonin Syndrome, also known as malignant carcinoid syndrome, is related to depression and fibromyalgia. An important gene associated with Serotonin Syndrome is HTR3A (5-Hydroxytryptamine Receptor 3A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Serotonergic synapse. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are no effect and Decreased viability

Wikipedia : 77 Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic... more...

Related Diseases for Serotonin Syndrome

Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 depression 30.3 HTR1A HTR2A MAOA SLC6A4
2 fibromyalgia 30.1 HTR2A HTR3A SLC6A4
3 post-traumatic stress disorder 29.7 HTR2A MAOA MAOB SLC6A4
4 parkinson disease, late-onset 29.7 CYP2D6 HTR1A HTR2A MAOA MAOB SLC6A4
5 migraine with or without aura 1 29.4 HTR1A HTR2A HTR3A MAOA SLC6A4 TAC1
6 obsessive-compulsive disorder 29.2 CYP2D6 HTR1A HTR2A HTR3A MAOA OXT
7 small cell cancer of the lung 29.2 CHGA GAST SST
8 anxiety 29.0 CYP2D6 CYP3A4 HTR1A HTR2A HTR3A MAOA
9 schizoid personality disorder 10.4 HTR1A HTR2A
10 hypoactive sexual desire disorder 10.4 HTR1A HTR2A
11 substance-induced psychosis 10.4 HTR1A HTR2A
12 avoidant personality disorder 10.4 MAOA SLC6A4
13 schizophrenia 5 10.4 HTR1A HTR2A HTR3A
14 rumination disorder 10.4 HTR1A HTR3A
15 phobic disorder 10.3 HTR1A MAOA SLC6A4
16 psychosexual disorder 10.3 HTR1A HTR2A SLC6A4
17 premature ejaculation 10.3 HTR1A HTR3A SLC6A4
18 dysthymic disorder 10.3 HTR2A MAOA SLC6A4
19 agoraphobia 10.3 HTR1A MAOA SLC6A4
20 periodic limb movement disorder 10.3 HTR1A HTR2A SLC6A4
21 dependent personality disorder 10.3 CYP3A4 MAOA MAOB
22 paranoid schizophrenia 10.3 HTR2A MAOA SLC6A4
23 antisocial personality disorder 10.3 MAOA MAOB SLC6A4
24 sexual disorder 10.3 HTR1A OXT SLC6A4
25 bipolar i disorder 10.3 HTR1A HTR2A SLC6A4
26 paraphilia disorder 10.3 MAOA MAOB OXT
27 tobacco addiction 10.3 HTR2A MAOA SLC6A4
28 substance abuse 10.3 CYP2D6 MAOA SLC6A4
29 gastrointestinal neuroendocrine tumor 10.3 CHGA SST
30 postpartum depression 10.3 MAOA OXT SLC6A4
31 hemangioma of liver 10.3 CYP3A4 IFNA2
32 substance dependence 10.3 CYP2D6 MAOA SLC6A4
33 social phobia 10.3 HTR1A HTR3A MAOA SLC6A4
34 neuroleptic malignant syndrome 10.3
35 intestinal neuroendocrine benign tumor 10.3 MEN1 SSTR1
36 atypical depressive disorder 10.2 HTR2A MAOA MAOB SLC6A4
37 borderline personality disorder 10.2 HTR1A HTR2A MAOA SLC6A4
38 personality disorder 10.2 HTR1A HTR2A MAOA SLC6A4
39 endogenous depression 10.2 HTR1A HTR2A MAOA SLC6A4
40 pathological gambling 10.2 HTR2A MAOA MAOB SLC6A4
41 pituitary carcinoma 10.2 CHGA SST
42 chronic fatigue syndrome 10.2 HTR1A HTR2A MAOA SLC6A4
43 kleptomania 10.2 CYP3A4 HTR1A MAOA SLC6A4
44 postgastrectomy syndrome 10.2 PYY SST
45 autoimmune atrophic gastritis 10.2 CHGA GAST
46 pancreatic somatostatinoma 10.2 MEN1 SST
47 dyspepsia 10.2 HTR1A HTR3A SLC6A4 SST
48 pylorospasm 10.2 GAST SST
49 tardive dyskinesia 10.2 CYP2D6 HTR2A
50 motion sickness 10.2 HTR1A HTR3A TAC1

Comorbidity relations with Serotonin Syndrome via Phenotypic Disease Network (PDN):


Intestinal Obstruction

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to Serotonin Syndrome

Symptoms & Phenotypes for Serotonin Syndrome

GenomeRNAi Phenotypes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 CGB3 CHGA CYP2D6 CYP3A4 GAST GHRH
2 Decreased viability GR00381-A-1 9.61 HTR1A HTR3A SLC6A4
3 Decreased viability GR00381-A-3 9.61 HTR1A HTR3A SLC6A4
4 Decreased viability GR00402-S-2 9.61 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Serotonin Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 HTR1A HTR2A HTR3A MAOA MAOB OXT
2 endocrine/exocrine gland MP:0005379 9.81 CHGA GAST GHRH HTR2A HTR3A MEN1
3 homeostasis/metabolism MP:0005376 9.8 CHGA GAST GHRH HTR1A HTR3A MAOA
4 nervous system MP:0003631 9.44 CHGA GHRH HTR1A HTR3A MAOA MAOB

Drugs & Therapeutics for Serotonin Syndrome

Search Clinical Trials , NIH Clinical Center for Serotonin Syndrome

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Serotonin Syndrome

Anatomical Context for Serotonin Syndrome

MalaCards organs/tissues related to Serotonin Syndrome:

42
Brain, Spinal Cord, Bone, Heart, Bone Marrow, Hypothalamus, Breast

Publications for Serotonin Syndrome

Articles related to Serotonin Syndrome:

(show top 50) (show all 678)
# Title Authors Year
1
An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System. ( 30650197 )
2019
2
Refining the Clinical Features of Serotonin Syndrome: A Prospective Observational Study of 45 Patients. ( 30692760 )
2019
3
Serotonin Syndrome After an Alcohol Intake in a Patient Treated With Escitalopram and Clomipramine. ( 30844852 )
2019
4
Serotonin syndrome unmasking thyrotoxicosis. ( 30850570 )
2019
5
Life-Threatening Serotonin Syndrome Due to Methylene Blue-Citalopram Interaction. ( 30855287 )
2019
6
Neuromuscular abnormalities in serotonin syndrome may be mistaken as seizure: A report and literature review. ( 30860132 )
2019
7
Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques. ( 30886699 )
2019
8
Serotonin Syndrome Following Tramadol and Gabapentin Use After Spine Surgery. ( 30898741 )
2019
9
Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. ( 29482205 )
2018
10
Serotonin Syndrome in Obstetrics: A Case Report and Review of Management. ( 29901770 )
2018
11
Serotonin, Syndrome ( 29493999 )
2018
12
Serotonin syndrome during a heat wave. ( 29437313 )
2018
13
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( 29795058 )
2018
14
Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome. ( 29210063 )
2018
15
Fentanyl-Associated Serotonin Syndrome and Chest Wall Rigidity in an Intensive Care Unit Patient. ( 29965805 )
2018
16
Severe Serotonin Syndrome in an Autistic New Psychoactive Substance User After Consumption of Pills Containing Methoxphenidine and I+-Methyltryptamine. ( 29210865 )
2018
17
Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect. ( 29872601 )
2018
18
Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. ( 29752906 )
2018
19
Serotonin syndrome versus neuroleptic malignant syndrome: a case report. ( 29616715 )
2018
20
A Mixed Presentation of Serotonin Syndrome vs Neuroleptic Malignant Syndrome in a 12-Year-Old Boy. ( 29698346 )
2018
21
Implications of Off-Target Serotoninergic Drug Activity - An Analysis of Serotonin Syndrome Reports using a Systematic Bioinformatics Approach. ( 29972695 )
2018
22
Serotonin Syndrome Following Septal Myectomy in Association With Fentanyl and Methylene Blue: A Case Report. ( 29571985 )
2018
23
Conservative management of severe serotonin syndrome with coma, myoclonus, and crossed-extensor reflex complicated by hepatic encephalopathy. ( 29686575 )
2018
24
Diaphoresis: A Presentation of Serotonin Syndrome From Vortioxetine. ( 29917334 )
2018
25
Association Between Serotonin Syndrome and Second-Generation Antipsychotics via Pharmacological Target-Adverse Event Analysis. ( 29575568 )
2018
26
The role of chronic nutritional supplements consumption in a fulminant serotonin syndrome due to citalopram intoxication. ( 29317102 )
2018
27
Neuroleptic malignant syndrome and serotonin syndrome. ( 30459031 )
2018
28
Use of methylene blue in hepatic arterial infusion pump resulting in serotonin syndrome. A case report. ( 29984362 )
2018
29
Serotonin Syndrome in the Perioperative Setting. ( 30008467 )
2018
30
Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis. ( 30056864 )
2018
31
Serotonin Syndrome Masquerading as Ventricular Tachycardia Storm. ( 30077498 )
2018
32
Serotonin Toxicity and Urinary Analgesics: A Case Report and Systematic Literature Review of Methylene Blue-Induced Serotonin Syndrome. ( 30104021 )
2018
33
The scoop on serotonin syndrome. ( 30237838 )
2018
34
Fluoxetine overdose in a teenager resulting in serotonin syndrome, seizure and delayed onset rhabdomyolysis. ( 30301727 )
2018
35
Is There Always a Right or Wrong?: Comments on the FDA Warnings About Triptans and the Serotonin Syndrome. ( 30303862 )
2018
36
Demystifying serotonin syndrome (or serotonin toxicity). ( 30315014 )
2018
37
Case of Serotonin Syndrome Initially Presenting as Diffuse Body Pain. ( 30318504 )
2018
38
Comment on Gressler et al.: Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research. ( 30380966 )
2018
39
Tramadol: Distinguishing the Pathophysiology of Serotonin Syndrome and Seizures. ( 30392647 )
2018
40
Serotonin Syndrome and Hippocampal Infarction. ( 30420109 )
2018
41
Serotonin Syndrome with Atypical Hypernatremia. ( 30680272 )
2018
42
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome. ( 28667541 )
2017
43
Metoclopramide-induced Serotonin Syndrome. ( 28321081 )
2017
44
Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome. ( 29134498 )
2017
45
Malignant Syndrome and Serotonin Syndrome in a General Hospital Setting: Clinical Features, Frequency and Prognosis. ( 28943544 )
2017
46
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome. ( 28057811 )
2017
47
Controversies in Serotonin Syndrome Diagnosis and Management: A Review. ( 29207768 )
2017
48
Methylene blue-induced serotonin syndrome after left ventricular assist device implantation: A case report and literature review. ( 28655448 )
2017
49
A review of vilazodone exposures with focus on serotonin syndrome effects. ( 28594246 )
2017
50
Comment on Tapentadol and Serotonin Syndrome. ( 28515499 )
2017

Variations for Serotonin Syndrome

Expression for Serotonin Syndrome

Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for Serotonin Syndrome

Pathways related to Serotonin Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 GHRH HTR1A HTR2A OXT PYY SST
2 11.56 CYP2D6 HTR1A HTR2A HTR3A MAOA MAOB
3 11.44 HTR1A HTR2A HTR3A MAOA SLC6A4 SST
4
Show member pathways
11.35 CYP2D6 CYP3A4 SLC6A4
5 11 HTR1A HTR2A HTR3A MAOA SLC6A4
6
Show member pathways
10.64 CYP2D6 CYP3A4 HTR3A
7
Show member pathways
10.63 MAOA MAOB
8 10.58 MAOA MAOB
9
Show member pathways
10.52 MAOA MAOB

GO Terms for Serotonin Syndrome

Cellular components related to Serotonin Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CGB3 CHGA GAST GHRH IFNA2 OXT
2 integral component of presynaptic membrane GO:0099056 9.43 HTR2A HTR3A SLC6A4
3 integral component of postsynaptic membrane GO:0099055 9.33 HTR2A HTR3A SLC6A4
4 extracellular region GO:0005576 9.32 CGB3 CHGA GAST GHRH IFNA2 NOTCH1

Biological processes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.93 HTR2A MAOB SLC6A4 SST
2 G protein-coupled receptor signaling pathway GO:0007186 9.81 GAST GHRH HTR1A HTR2A OXT PYY
3 neuropeptide signaling pathway GO:0007218 9.79 PYY SSTR1 TAC1
4 chemical synaptic transmission GO:0007268 9.77 HTR1A HTR2A HTR3A SST TAC1
5 memory GO:0007613 9.76 HTR2A OXT SLC6A4
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 GHRH HTR2A OXT TAC1
7 cell-cell signaling GO:0007267 9.72 CGB3 GHRH IFNA2 SST TAC1
8 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.71 HTR1A HTR2A SSTR1
9 negative regulation of cell-substrate adhesion GO:0010812 9.62 MEN1 NOTCH1
10 vasoconstriction GO:0042310 9.62 HTR1A SLC6A4
11 positive regulation of ossification GO:0045778 9.61 OXT TAC1
12 positive regulation of renal sodium excretion GO:0035815 9.6 OXT TAC1
13 sleep GO:0030431 9.59 HTR2A OXT
14 neurotransmitter catabolic process GO:0042135 9.58 MAOA MAOB
15 response to steroid hormone GO:0048545 9.58 MAOB OXT SST
16 behavior GO:0007610 9.57 HTR1A HTR2A
17 oxidative demethylation GO:0070989 9.56 CYP2D6 CYP3A4
18 dopamine catabolic process GO:0042420 9.55 MAOA MAOB
19 heterocycle metabolic process GO:0046483 9.52 CYP2D6 CYP3A4
20 drug catabolic process GO:0042737 9.51 CYP2D6 CYP3A4
21 monoterpenoid metabolic process GO:0016098 9.49 CYP2D6 CYP3A4
22 sperm ejaculation GO:0042713 9.48 OXT SLC6A4
23 alkaloid catabolic process GO:0009822 9.43 CYP2D6 CYP3A4
24 response to food GO:0032094 9.43 GAST GHRH OXT
25 regulation of signaling receptor activity GO:0010469 9.17 CGB3 GAST GHRH IFNA2 OXT PYY
26 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR3A

Molecular functions related to Serotonin Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CGB3 GAST GHRH OXT PYY SST
2 neuropeptide hormone activity GO:0005184 9.33 GHRH OXT PYY
3 primary amine oxidase activity GO:0008131 9.26 MAOA MAOB
4 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR3A SLC6A4

Sources for Serotonin Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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