MCID: SRS004
MIFTS: 29

Serous Labyrinthitis

Categories: Ear diseases

Aliases & Classifications for Serous Labyrinthitis

MalaCards integrated aliases for Serous Labyrinthitis:

Name: Serous Labyrinthitis 12 15 70
Acute Serous Labyrinthitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1467
ICD9CM 34 386.31
SNOMED-CT 67 41674001
UMLS 70 C0155504

Summaries for Serous Labyrinthitis

Disease Ontology : 12 A labyrinthitits in which bacterial toxins invade the inner ear. It is the most common complication of acute or chronic middle ear infections.

MalaCards based summary : Serous Labyrinthitis, also known as acute serous labyrinthitis, is related to labyrinthitis and otitis media. An important gene associated with Serous Labyrinthitis is ATOH1 (Atonal BHLH Transcription Factor 1), and among its related pathways/superpathways are Akt Signaling and CCR5 Pathway in Macrophages. Affiliated tissues include lung, skin and bone, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Serous Labyrinthitis

Diseases related to Serous Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 labyrinthitis 30.9 SLC26A4 NF2 GJB2 ATOH1
2 otitis media 30.3 TLR2 CCL11 ALB
3 viral labyrinthitis 10.3 GJB2 ATOH1
4 autosomal recessive nonsyndromic deafness 3 10.3 SLC26A4 GJB2
5 deafness, autosomal dominant 56 10.3 SLC26A4 GJB2
6 deafness, autosomal recessive 7 10.3 SLC26A4 GJB2
7 deafness, autosomal recessive 77 10.3 SLC26A4 GJB2
8 deafness, autosomal dominant 41 10.3 SLC26A4 GJB2
9 deafness, autosomal dominant 6 10.3 SLC26A4 GJB2
10 eustachian tube disease 10.2 CCL11 ATOH1
11 patulous eustachian tube 10.2 CCL11 ATOH1
12 deafness, autosomal dominant 36 10.2 SLC26A4 GJB2
13 drug-induced hearing loss 10.2 SLC26A4 GJB2 ATOH1
14 ear malformation 10.2 SLC26A4 GJB2 ATOH1
15 vestibular disease 10.2 SLC26A4 GJB2
16 deafness, autosomal recessive 1a 10.2 SLC26A4 GJB2 ATOH1
17 x-linked nonsyndromic deafness 10.2 SLC26A4 GJB2
18 auditory system disease 10.2 SLC26A4 GJB2 ATOH1
19 inner ear disease 10.2 SLC26A4 GJB2 ATOH1
20 deafness, autosomal dominant 9 10.2 SLC26A4 GJB2
21 autosomal dominant nonsyndromic deafness 10.2 SLC26A4 GJB2 ATOH1
22 deafness, autosomal recessive 2 10.2 SLC26A4 GJB2
23 diclofenac allergy 10.2 CCR3 ALB
24 congenital cytomegalovirus 10.2 TLR2 GJB2
25 sodoku disease 10.2 CCL7 CCL11
26 peripheral vertigo 10.2 SLC26A4 GJB2
27 suppurative otitis media 10.1
28 chronic purulent otitis media 10.1
29 pathologic nystagmus 10.1
30 cranial nerve neoplasm 10.1 NF2 AVP
31 otosclerosis 10.1 SLC26A4 NF2 GJB2
32 meniere disease 10.1 SLC26A4 GJB2 AVP
33 corneal ulcer 10.1 CCR3 CCR1 CCL11
34 pulmonary eosinophilia 10.1 CCR3 CCL7 CCL11
35 benign essential hypertension 10.1 AVP ALB
36 paralytic ileus 10.1 AVP ALB
37 chronic meningitis 10.1 CCL11 ALB
38 central pontine myelinolysis 10.1 AVP ALB
39 facial nerve disease 10.1 NF2 ALB
40 facial paralysis 10.0 NF2 ALB
41 cranial nerve palsy 10.0 AVP ALB
42 inappropriate adh syndrome 10.0 AVP ALB
43 analbuminemia 10.0 AVP ALB
44 purulent labyrinthitis 10.0 TLR2 NF2 GJB2
45 disease by infectious agent 10.0
46 cat-scratch disease 10.0
47 blood group, globoside system 10.0 TLR2 ALB
48 nasal cavity disease 10.0 CCR3 CCL11 ALB
49 primary systemic mycosis 10.0 TLR2 ALB
50 nose disease 10.0 CCR3 CCL11 ALB

Graphical network of the top 20 diseases related to Serous Labyrinthitis:



Diseases related to Serous Labyrinthitis

Symptoms & Phenotypes for Serous Labyrinthitis

MGI Mouse Phenotypes related to Serous Labyrinthitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ALB ATOH1 AVP CCR1 CCR2 CCR3
2 immune system MP:0005387 10 ALB AVP CCL11 CCR1 CCR2 CCR3
3 digestive/alimentary MP:0005381 9.85 ALB ATOH1 CCR1 CCR2 SLC26A4 TLR2
4 liver/biliary system MP:0005370 9.63 ALB CCR1 CCR2 NF2 PDCD1 TLR2
5 renal/urinary system MP:0005367 9.56 ALB AVP CCR1 CCR2 NF2 PDCD1
6 respiratory system MP:0005388 9.28 ATOH1 AVP CCL11 CCR1 CCR2 CCR3

Drugs & Therapeutics for Serous Labyrinthitis

Search Clinical Trials , NIH Clinical Center for Serous Labyrinthitis

Genetic Tests for Serous Labyrinthitis

Anatomical Context for Serous Labyrinthitis

MalaCards organs/tissues related to Serous Labyrinthitis:

40
Lung, Skin, Bone

Publications for Serous Labyrinthitis

Articles related to Serous Labyrinthitis:

(show all 29)
# Title Authors PMID Year
1
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. 61
30870366 2019
2
Deterioration of Vestibular Cells in Labyrinthitis. 61
27881797 2017
3
Nystagmus in patients with unilateral acute otitis media complicated by serous labyrinthitis. 61
26797398 2016
4
Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study. 61
26954857 2016
5
Serous labyrinthitis as a manifestation of cat scratch disease: a case report. 61
20519021 2009
6
Tuberculous otitis in infants: temporal bone histopathology and clinical extrapolation. 61
16868514 2006
7
A case of tympanogenic labyrinthitis complicated by acute otitis media. 61
15744821 2005
8
[Chronic suppurative otitis media complicated diffuse serous labyrinthitis: 4 cases report]. 61
11263216 1998
9
Intratemporal complications of acute otitis media in infants and children. 61
9807067 1998
10
Otitis media: pathogenesis and medical sequelae. 61
9674327 1998
11
Histopathology of labyrinthine fistulae in chronic otitis media with clinical implications. 61
8989947 1997
12
A human temporal bone study of acute bacterial meningogenic labyrinthitis. 61
8817013 1996
13
Is the vestibular system affected by middle ear effusion? 61
8414557 1993
14
[Inner ear changes in fetal asphyxia]. 61
2029306 1991
15
[Inner ear damage induced by bacteria (Mycobacterium chelonae)]. 61
2348283 1990
16
Labyrinthine fistulae caused by cholesteatoma. Improved bone conduction by treatment. 61
2719088 1989
17
Stapes prosthesis: evaluation with CT. 61
3940377 1986
18
[Clinical characteristics of chronic serous labyrinthitis]. 61
3904146 1985
19
Pathology as it relates to ear surgery. IV. Surgery of Menière's disease. 61
6693814 1984
20
Inner ear hearing loss in acute and chronic otitis media. 61
7034493 1981
21
[On the protein composition of the inner ear perilymph in experimentally induced serous labyrinthitis]. 61
5671855 1968
22
[Changes in the glands of the crista ampullaris in experimental serous labyrinthitis]. 61
14013938 1963
23
[A case of diffuse serous labyrinthitis with recovery]. 61
13774408 1961
24
[Serous labyrinthitis after labyrinth-fenestration]. 61
14383594 1955
25
Calibrated Weber test in fenestration surgery; evaluation of postoperative serous labyrinthitis. 61
13057454 1953
26
[Method of control of serous labyrinthitis and hydrops of the labyrinth following fenestration]. 61
13082709 1953
27
[Case of furunculosis of the external acoustic duct complicated by serous labyrinthitis]. 61
14876921 1951
28
Bilateral Chronic Suppurative Otitis Media. Acute Serous Labyrinthitis of Right Ear. Radical Mastoid Operation in Quiescent Stage. Modified Radical Operation Left Ear. 61
19991398 1938
29
Recovery of Hearing after Serous Labyrinthitis and Apparent Complete Loss Seven Months Previously. 61
19989799 1934

Variations for Serous Labyrinthitis

Expression for Serous Labyrinthitis

Search GEO for disease gene expression data for Serous Labyrinthitis.

Pathways for Serous Labyrinthitis

Pathways related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 TLR2 CCR3 CCR2 CCR1 CCL7 CCL11
2
Show member pathways
12.31 CCR3 CCR2 CCR1 CCL7 CCL11
3
Show member pathways
11.36 CCR3 CCR2 CCR1 CCL7 CCL11
4 10.93 CCR3 CCR2 CCL11
5 10.72 TLR2 CCR3

GO Terms for Serous Labyrinthitis

Cellular components related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 TLR2 SLC26A4 GJB2 CCR3 CCR2 CCR1
2 external side of plasma membrane GO:0009897 9.26 PDCD1 CCR3 CCR2 CCR1
3 cell body GO:0044297 8.8 TLR2 NF2 GJB2

Biological processes related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.07 TLR2 CCR3 CCR2 CCR1 CCL7 CCL11
2 G protein-coupled receptor signaling pathway GO:0007186 9.97 CCR3 CCR2 CCR1 CCL7 CCL11 AVP
3 immune response GO:0006955 9.73 TLR2 CCR3 CCR2 CCR1 CCL7 CCL11
4 cell-cell signaling GO:0007267 9.71 GJB2 CCR1 CCL7 AVP
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.67 CCR3 CCR2 CCR1 AVP
6 cellular response to interferon-gamma GO:0071346 9.65 TLR2 CCL7 CCL11
7 cell chemotaxis GO:0060326 9.63 CCR3 CCR2 CCR1
8 inflammatory response GO:0006954 9.63 TLR2 CCR3 CCR2 CCR1 CCL7 CCL11
9 cellular calcium ion homeostasis GO:0006874 9.62 CCR2 CCR1 CCL7 CCL11
10 calcium-mediated signaling GO:0019722 9.61 CCR3 CCR2 CCR1
11 positive regulation of monocyte chemotaxis GO:0090026 9.55 CCR2 CCR1
12 eosinophil chemotaxis GO:0048245 9.54 CCL7 CCL11
13 dendritic cell chemotaxis GO:0002407 9.51 CCR2 CCR1
14 chemotaxis GO:0006935 9.35 CCR3 CCR2 CCR1 CCL7 CCL11
15 chemokine-mediated signaling pathway GO:0070098 9.02 CCR3 CCR2 CCR1 CCL7 CCL11

Molecular functions related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 C-C chemokine binding GO:0019957 9.33 CCR3 CCR2 CCR1
2 CCR chemokine receptor binding GO:0048020 9.32 CCL7 CCL11
3 CCR2 chemokine receptor binding GO:0031727 9.26 CCR2 CCL7
4 C-C chemokine receptor activity GO:0016493 9.13 CCR3 CCR2 CCR1
5 chemokine receptor activity GO:0004950 8.8 CCR3 CCR2 CCR1

Sources for Serous Labyrinthitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....