MCID: SRS004
MIFTS: 28

Serous Labyrinthitis

Categories: Ear diseases

Aliases & Classifications for Serous Labyrinthitis

MalaCards integrated aliases for Serous Labyrinthitis:

Name: Serous Labyrinthitis 12 15 71
Acute Serous Labyrinthitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1467
ICD9CM 34 386.31
SNOMED-CT 67 41674001
UMLS 71 C0155504

Summaries for Serous Labyrinthitis

Disease Ontology : 12 A labyrinthitits in which bacterial toxins invade the inner ear. It is the most common complication of acute or chronic middle ear infections.

MalaCards based summary : Serous Labyrinthitis, also known as acute serous labyrinthitis, is related to labyrinthitis and viral labyrinthitis. An important gene associated with Serous Labyrinthitis is PATE1 (Prostate And Testis Expressed 1), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. Affiliated tissues include bone and testes, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Serous Labyrinthitis

Diseases related to Serous Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 labyrinthitis 30.7 SLC26A4 PATE1 NF2 GJB2 ATOH1
2 viral labyrinthitis 10.4 GJB2 ATOH1
3 autosomal recessive nonsyndromic deafness 3 10.4 SLC26A4 GJB2
4 deafness, autosomal recessive 7 10.4 SLC26A4 GJB2
5 otitis media 10.4
6 deafness, autosomal recessive 77 10.4 SLC26A4 GJB2
7 deafness, autosomal dominant 56 10.4 SLC26A4 GJB2
8 deafness, autosomal dominant 41 10.3 SLC26A4 GJB2
9 drug-induced hearing loss 10.3 SLC26A4 GJB2 ATOH1
10 ear malformation 10.3 SLC26A4 GJB2 ATOH1
11 deafness, autosomal recessive 16 10.3 SLC26A4 GJB2
12 deafness, autosomal recessive 1a 10.3 SLC26A4 GJB2 ATOH1
13 eosinophilic gastritis 10.3 CCR3 CCL11
14 auditory system disease 10.3 SLC26A4 GJB2 ATOH1
15 diclofenac allergy 10.2 CCR3 ALB
16 autosomal dominant nonsyndromic deafness 10.2 SLC26A4 GJB2 ATOH1
17 deafness, autosomal dominant 36 10.2 SLC26A4 GJB2
18 purulent labyrinthitis 10.2 NF2 GJB2 EPB41
19 hypochondriasis 10.2 NTF4 NTF3
20 cataract 38 10.2 NTF4 NTF3
21 deafness, autosomal dominant 6 10.2 SLC26A4 GJB2
22 suppurative otitis media 10.1
23 chronic purulent otitis media 10.1
24 pathologic nystagmus 10.1
25 otosclerosis 10.1 SLC26A4 NF2 GJB2
26 corneal ulcer 10.1 CCR3 CCR1 CCL11
27 pulmonary eosinophilia 10.1 CCR3 CCL7 CCL11
28 sodoku disease 10.1 CCL7 CCL11
29 vestibular disease 10.1 SLC26A4 GJB2 AVP
30 peripheral vertigo 10.1 SLC26A4 GJB2 AVP
31 toxic labyrinthitis 10.0 SLC26A4 HECTD4
32 cranial nerve neoplasm 10.0 NF2 AVP
33 cat-scratch disease 10.0
34 paralytic ileus 10.0 AVP ALB
35 nasal cavity disease 10.0 CCR3 CCL11 ALB
36 nose disease 10.0 CCR3 CCL11 ALB
37 chronic meningitis 9.9 CCL11 ALB
38 allergic hypersensitivity disease 9.9 CCR3 CCL7 CCL11
39 bronchial disease 9.9 CCR3 CCL11 ALB
40 bronchitis 9.9 CCR3 CCL11 ALB
41 human immunodeficiency virus infectious disease 9.8 PDCD1 ERVW-1 CCR3 CCL7
42 inner ear disease 9.8 SLC26A4 HECTD4 GJB2
43 lymphangitis 9.8 HECTD4 ALB
44 miliary tuberculosis 9.7 PDCD1 ALB
45 hemoglobin d disease 9.7 HECTD4 ALB
46 mononeuritis of lower limb 9.7 NTF4 NTF3 HECTD4
47 inappropriate adh syndrome 9.7 AVP ALB
48 dermatitis, atopic 9.6 NTF4 NTF3 CCR3 CCL7 CCL11
49 sensory peripheral neuropathy 9.6 NTF3 HECTD4 ALB
50 analbuminemia 9.5 AVP ALB

Graphical network of the top 20 diseases related to Serous Labyrinthitis:



Diseases related to Serous Labyrinthitis

Symptoms & Phenotypes for Serous Labyrinthitis

MGI Mouse Phenotypes related to Serous Labyrinthitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ALB ATOH1 AVP CCR1 CCR2 CCR3
2 immune system MP:0005387 9.9 ALB AVP CCL11 CCR1 CCR2 CCR3
3 renal/urinary system MP:0005367 9.56 ALB AVP CCR1 CCR2 EPB41 NF2
4 respiratory system MP:0005388 9.23 ATOH1 CCL11 CCR1 CCR2 CCR3 NF2

Drugs & Therapeutics for Serous Labyrinthitis

Search Clinical Trials , NIH Clinical Center for Serous Labyrinthitis

Genetic Tests for Serous Labyrinthitis

Anatomical Context for Serous Labyrinthitis

MalaCards organs/tissues related to Serous Labyrinthitis:

40
Bone, Testes

Publications for Serous Labyrinthitis

Articles related to Serous Labyrinthitis:

(show all 29)
# Title Authors PMID Year
1
Direction-Changing Positional Nystagmus in Acute Otitis Media Complicated by Serous Labyrinthitis: New Insights into Positional Nystagmus. 61
30870366 2019
2
Deterioration of Vestibular Cells in Labyrinthitis. 61
27881797 2017
3
Nystagmus in patients with unilateral acute otitis media complicated by serous labyrinthitis. 61
26797398 2016
4
Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study. 61
26954857 2016
5
Serous labyrinthitis as a manifestation of cat scratch disease: a case report. 61
20519021 2009
6
Tuberculous otitis in infants: temporal bone histopathology and clinical extrapolation. 61
16868514 2006
7
A case of tympanogenic labyrinthitis complicated by acute otitis media. 61
15744821 2005
8
[Chronic suppurative otitis media complicated diffuse serous labyrinthitis: 4 cases report]. 61
11263216 1998
9
Intratemporal complications of acute otitis media in infants and children. 61
9807067 1998
10
Otitis media: pathogenesis and medical sequelae. 61
9674327 1998
11
Histopathology of labyrinthine fistulae in chronic otitis media with clinical implications. 61
8989947 1997
12
A human temporal bone study of acute bacterial meningogenic labyrinthitis. 61
8817013 1996
13
Is the vestibular system affected by middle ear effusion? 61
8414557 1993
14
[Inner ear changes in fetal asphyxia]. 61
2029306 1991
15
[Inner ear damage induced by bacteria (Mycobacterium chelonae)]. 61
2348283 1990
16
Labyrinthine fistulae caused by cholesteatoma. Improved bone conduction by treatment. 61
2719088 1989
17
Stapes prosthesis: evaluation with CT. 61
3940377 1986
18
[Clinical characteristics of chronic serous labyrinthitis]. 61
3904146 1985
19
Pathology as it relates to ear surgery. IV. Surgery of Menière's disease. 61
6693814 1984
20
Inner ear hearing loss in acute and chronic otitis media. 61
7034493 1981
21
[On the protein composition of the inner ear perilymph in experimentally induced serous labyrinthitis]. 61
5671855 1968
22
[Changes in the glands of the crista ampullaris in experimental serous labyrinthitis]. 61
14013938 1963
23
[A case of diffuse serous labyrinthitis with recovery]. 61
13774408 1961
24
[Serous labyrinthitis after labyrinth-fenestration]. 61
14383594 1955
25
Calibrated Weber test in fenestration surgery; evaluation of postoperative serous labyrinthitis. 61
13057454 1953
26
[Method of control of serous labyrinthitis and hydrops of the labyrinth following fenestration]. 61
13082709 1953
27
[Case of furunculosis of the external acoustic duct complicated by serous labyrinthitis]. 61
14876921 1951
28
Bilateral Chronic Suppurative Otitis Media. Acute Serous Labyrinthitis of Right Ear. Radical Mastoid Operation in Quiescent Stage. Modified Radical Operation Left Ear. 61
19991398 1938
29
Recovery of Hearing after Serous Labyrinthitis and Apparent Complete Loss Seven Months Previously. 61
19989799 1934

Variations for Serous Labyrinthitis

Expression for Serous Labyrinthitis

Search GEO for disease gene expression data for Serous Labyrinthitis.

Pathways for Serous Labyrinthitis

Pathways related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 NTF4 NTF3 CCR3 CCR2 CCR1 CCL7
2
Show member pathways
12.62 NTF4 NTF3 EPB41 CCR3 CCR2 CCR1
3
Show member pathways
12.48 CCR3 CCR2 CCR1 CCL7 CCL11
4
Show member pathways
11.36 CCR3 CCR2 CCR1 CCL7 CCL11
5 11.13 CCR3 CCR2 CCL11

GO Terms for Serous Labyrinthitis

Biological processes related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.17 NTF4 NTF3 CCR3 CCR2 CCR1 CCL7
2 immune response GO:0006955 9.85 CCR3 CCR2 CCR1 CCL7 CCL11
3 inflammatory response GO:0006954 9.83 CCR3 CCR2 CCR1 CCL7 CCL11
4 positive regulation of cell migration GO:0030335 9.78 NTF3 CCR1 CCL7 CCL11
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.7 NTF4 NTF3 AVP
6 cell chemotaxis GO:0060326 9.69 CCR3 CCR2 CCR1
7 calcium-mediated signaling GO:0019722 9.67 CCR3 CCR2 CCR1
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.67 CCR3 CCR2 CCR1 AVP
9 positive regulation of monocyte chemotaxis GO:0090026 9.58 CCR2 CCR1
10 monocyte chemotaxis GO:0002548 9.58 CCR2 CCL7 CCL11
11 dendritic cell chemotaxis GO:0002407 9.56 CCR2 CCR1
12 cellular calcium ion homeostasis GO:0006874 9.56 CCR2 CCR1 CCL7 CCL11
13 nerve development GO:0021675 9.55 NTF4 NTF3
14 cell-cell signaling GO:0007267 9.55 NTF3 GJB2 CCR1 CCL7 AVP
15 nerve growth factor signaling pathway GO:0038180 9.54 NTF4 NTF3
16 regulation of neuron differentiation GO:0045664 9.5 NTF4 NTF3 ATOH1
17 chemotaxis GO:0006935 9.35 CCR3 CCR2 CCR1 CCL7 CCL11
18 chemokine-mediated signaling pathway GO:0070098 9.02 CCR3 CCR2 CCR1 CCL7 CCL11

Molecular functions related to Serous Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.43 CCR3 CCR2 CCR1
2 CCR2 chemokine receptor binding GO:0031727 9.4 CCR2 CCL7
3 nerve growth factor receptor binding GO:0005163 9.37 NTF4 NTF3
4 C-C chemokine binding GO:0019957 9.33 CCR3 CCR2 CCR1
5 chemokine (C-C motif) ligand 7 binding GO:0035717 9.32 CCR2 CCR1
6 C-C chemokine receptor activity GO:0016493 9.13 CCR3 CCR2 CCR1
7 chemokine receptor activity GO:0004950 8.8 CCR3 CCR2 CCR1

Sources for Serous Labyrinthitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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