Serrated Polyposis Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SRR001 MIFTS: 42	Serrated Polyposis Syndrome Categories: Gastrointestinal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Serrated Polyposis Syndrome

MalaCards integrated aliases for Serrated Polyposis Syndrome:

Name: Serrated Polyposis Syndrome ⁵⁸

Hyperplastic Polyposis Syndrome ⁵⁸

Serrated Polyposis ⁶

Characteristics:

Orphanet epidemiological data:

⁵⁸

serrated polyposis syndrome
Inheritance: Autosomal dominant,Multigenic/multifactorial;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Benign neoplasms

Benign neoplasm of colon, rectum, anus and anal canal

Benign neoplasm: Colon, unspecified

Orphanet: ⁵⁸

Rare gastroenterological diseases

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Summaries for Serrated Polyposis Syndrome

MalaCards based summary : Serrated Polyposis Syndrome, also known as hyperplastic polyposis syndrome, is related to adenoma and familial adenomatous polyposis 2. An important gene associated with Serrated Polyposis Syndrome is RNF43 (Ring Finger Protein 43), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, breast and prostate, and related phenotypes are colorectal polyposis and adenomatous colonic polyposis

Wikipedia : ⁷³ Serrated polyposis syndrome (SPS), previously known as hyperplastic polyposis syndrome, is a disorder... more...

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Related Diseases for Serrated Polyposis Syndrome

Diseases related to Serrated Polyposis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)

#	Related Disease	Score	Top Affiliating Genes
1	adenoma	30.2	MUTYH KRAS BRAF APC
2	familial adenomatous polyposis 2	30.1	MUTYH APC
3	attenuated familial adenomatous polyposis	30.1	MUTYH APC
4	familial adenomatous polyposis	30.0	MUTYH KRAS APC
5	myh-associated polyposis	29.8	MUTYH KRAS APC
6	hereditary mixed polyposis syndrome	29.7	PTEN MUTYH GREM1
7	familial colorectal cancer	29.4	MUTYH GREM1 BRAF APC
8	adenocarcinoma	29.4	PTEN KRAS BRAF APC
9	colon adenocarcinoma	29.4	PTEN KRAS BRAF APC
10	colorectal adenoma	29.2	PTEN MUTYH KRAS GREM1 APC
11	lynch syndrome	28.2	RNF43 PTEN MUTYH KRAS BRAF APC
12	colorectal cancer	10.5
13	urachal adenocarcinoma	10.2	KRAS BRAF
14	apocrine adenoma	10.2	KRAS BRAF
15	schopf-schulz-passarge syndrome	10.2
16	inflammatory bowel disease	10.2
17	acneiform dermatitis	10.2	KRAS BRAF
18	syringocystadenoma papilliferum	10.2	KRAS BRAF
19	endosalpingiosis	10.2	KRAS BRAF
20	struma ovarii	10.2	KRAS BRAF
21	rosai-dorfman disease	10.2	KRAS BRAF
22	mature teratoma	10.1	KRAS BRAF
23	thyroid tumor	10.1	PTEN BRAF
24	ampulla of vater benign neoplasm	10.1	KRAS APC
25	periampullary adenoma	10.1	KRAS APC
26	rectosigmoid cancer	10.1	MUTYH KRAS
27	ovarian clear cell adenofibroma	10.0	PTEN KRAS
28	acral lentiginous melanoma	10.0	PTEN BRAF
29	duodenum cancer	10.0	MUTYH KRAS
30	paroxysmal nonkinesigenic dyskinesia 1	10.0
31	lymphoma, hodgkin, classic	10.0
32	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	10.0
33	gastric cancer	10.0
34	sessile serrated polyposis cancer syndrome	10.0
35	lymphoma	10.0
36	anal canal adenocarcinoma	10.0
37	47,xyy	10.0
38	mutyh polyposis	10.0
39	thyroid carcinoma	10.0
40	duodenum disease	10.0	MUTYH KRAS
41	primary mediastinal b-cell lymphoma	10.0	KRAS BRAF
42	gliomatosis cerebri	10.0	PTEN BRAF
43	endometrioid ovary carcinoma	10.0	PTEN KRAS
44	large intestine adenocarcinoma	10.0	PTEN KRAS
45	endometrial serous adenocarcinoma	10.0	PTEN KRAS
46	female reproductive endometrioid cancer	10.0	PTEN KRAS
47	skin papilloma	10.0	PTEN KRAS
48	tumor predisposition syndrome	10.0
49	cutaneous telangiectasia and cancer syndrome, familial	10.0
50	ulcerative colitis	10.0

Graphical network of the top 20 diseases related to Serrated Polyposis Syndrome:

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Symptoms & Phenotypes for Serrated Polyposis Syndrome

Human phenotypes related to Serrated Polyposis Syndrome:

⁵⁸ ³¹ (show all 14)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	colorectal polyposis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0200063
2	adenomatous colonic polyposis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0005227
3	gastric diverticulum ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0100808
4	melanoma ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0002861
5	breast carcinoma ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0003002
6	pancreatic adenocarcinoma ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0006725
7	biliary tract neoplasm ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0100574
8	ovarian neoplasm ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0100615
9	hodgkin lymphoma ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0012189
10	schwannoma ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0100008
11	prostate cancer ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0012125
12	bladder carcinoma ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0002862
13	germ cell neoplasia ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0100728
14	neoplasm of the large intestine ⁵⁸		Occasional (29-5%)

GenomeRNAi Phenotypes related to Serrated Polyposis Syndrome according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.02	BRAF FBLN2 KRAS MUTYH PTEN

MGI Mouse Phenotypes related to Serrated Polyposis Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.91	APC BRAF GREM1 KRAS MUTYH PTEN
2	digestive/alimentary	MP:0005381	9.72	APC BRAF KRAS PTEN RNF43
3	limbs/digits/tail	MP:0005371	9.65	APC BRAF GREM1 KRAS PTEN
4	neoplasm	MP:0002006	9.63	APC BRAF KRAS MUTYH PTEN RNF43
5	pigmentation	MP:0001186	9.26	APC BRAF KRAS PTEN
6	renal/urinary system	MP:0005367	9.02	APC BRAF GREM1 KRAS PTEN

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Drugs & Therapeutics for Serrated Polyposis Syndrome

Drugs for Serrated Polyposis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Cola

Interventional clinical trials:

#	Name	Status	NCT ID
1	Effectiveness of a Personalized Endoscopic Surveillance Protocol for Patients With Serrated Polyposis Syndrome	Completed	NCT03450889
2	Endocuff-assisted vs. Standard Colonoscopy for Surveillance of Serrated Polyposis Syndrome: A Randomized Controlled Trial	Completed	NCT02592603
3	Panchromoendoscopy for the Surveillance of Serrated Polyposis Syndrome, a Multicenter, Prospective and Randomized Trial.	Completed	NCT03476434

Search NIH Clinical Center for Serrated Polyposis Syndrome

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Genetic Tests for Serrated Polyposis Syndrome

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Anatomical Context for Serrated Polyposis Syndrome

MalaCards organs/tissues related to Serrated Polyposis Syndrome:

⁴⁰

Colon, Breast, Prostate, Appendix

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Publications for Serrated Polyposis Syndrome

Articles related to Serrated Polyposis Syndrome:

(show top 50) (show all 146)

#	Title	Authors	PMID	Year
1	A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred. ⁶¹ ⁶	Taupin D...Cook MC	27081527	2015
2	Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. ⁶¹ ⁶	Gala MK...Chung DC	24512911	2014
3	RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps. ⁶¹	van Herwaarden YJ...Nagtegaal ID	33098683	2021
4	Long-Term Incidence of Advanced Colorectal Neoplasia in Patients with Serrated Polyposis Syndrome: Experience in a Single Academic Centre. ⁶¹	Rodriguez-Alcalde D...Moreno-Sanchez D	33802297	2021
5	Serrated Lesions in Inflammatory Bowel Disease: Genotype-Phenotype Correlation. ⁶¹	Brcic I...Kashofer K	33030071	2021
6	Germline and Somatic Whole-Exome Sequencing Identifies New Candidate Genes Involved in Familial Predisposition to Serrated Polyposis Syndrome. ⁶¹	Soares de Lima Y...Castellvi-Bel S	33672345	2021
7	Long-Term Outcomes of Patients with Serrated Polyposis Syndrome. ⁶¹	Liu MC...Anderson JC	33307031	2021
8	Is it time to consider prophylactic appendectomy in patients with serrated polyposis syndrome undergoing surveillance? ⁶¹	McKay O...Bourke MJ	32694174	2021
9	Long-term surveillance in individuals with serrated polyposis syndrome. ⁶¹	Kedrin D...Anderson JC	33160491	2020
10	The long-term outcomes and natural disease course of serrated polyposis syndrome: over 10 years of prospective follow-up in a specialized center. ⁶¹	Bleijenberg AGC...Dekker E	32360902	2020
11	Correction: Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study. ⁶¹		32895331	2020
12	A natural language-based tool for diagnosis of serrated polyposis syndrome. ⁶¹	Parthasarathy G...Burke CA	32417299	2020
13	Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility. ⁶¹	Arnau-Collell C...Castellvi-Bel S	32170005	2020
14	Serrated Polyposis Syndrome with a Synchronous Colon Adenocarcinoma Treated by an Endoscopic Mucosal Resection. ⁶¹	Lee SH...Lee SK	32969364	2020
15	Serrated Polyposis Syndrome: Increasing Awareness and Importance. ⁶¹	Song H...Yap JEL	32821553	2020
16	First case of serrated lesion of the duodenal papilla in a patient with serrated colonic polyposis. ⁶¹	Becq A...Dray X	32651077	2020
17	Optimal Endoscopic Treatment and Surveillance of Serrated Polyps. ⁶¹	Gupta V...East JE	31581390	2020
18	Update on the World Health Organization Criteria for Diagnosis of Serrated Polyposis Syndrome. ⁶¹	Dekker E...Dutch-Spanish-British Serrated Polyposis Syndrome collaboration	31982410	2020
19	Serrated Polyposis Syndrome. ⁶¹	Mankaney G...Burke CA	31520728	2020
20	The (ir)relevance of the abandoned criterion II for the diagnosis of serrated polyposis syndrome: a retrospective cohort study. ⁶¹	Bleijenberg AGC...Dekker E	31853684	2020
21	Narrow-band imaging and high-definition white-light endoscopy in patients with serrated lesions not fulfilling criteria for serrated polyposis syndrome: a randomized controlled trial with tandem colonoscopy. ⁶¹	Riu Pons F...Bessa X	32299380	2020
22	Ocular manifestations in celiac disease: an overview. ⁶¹	Fousekis FS...Christodoulou DK	31916055	2020
23	A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors. ⁶¹	Biller LH...Yurgelun MB	32051178	2020
24	Sessile Serrated Polyposis: Not an Inherited Syndrome? ⁶¹	Cauley CE...Church J	31914111	2020
25	Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study. ⁶¹	Bleijenberg AG...Dekker E	30981990	2020
26	Hereditary or Not? Understanding Serrated Polyposis Syndrome. ⁶¹	Stanich PP...Pearlman R	31673925	2019
27	Contribution to colonic polyposis of recently proposed predisposing genes and assessment of the prevalence of NTHL1- and MSH3-associated polyposes. ⁶¹	Terradas M...Valle L	31243857	2019
28	Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing. ⁶¹	Toma C...Castellvi-Bel S	31663907	2019
29	Practical management of polyposis syndromes. ⁶¹	Patel R...Hyer W	31656563	2019
30	Update on genetic predisposition to colorectal cancer and polyposis. ⁶¹	Valle L...Hemminki K	30862463	2019
31	Panchromoendoscopy Increases Detection of Polyps in Patients With Serrated Polyposis Syndrome. ⁶¹	Lopez-Vicente J...Endoscopy for High Risk Cancer Conditions group of the Spanish Gastroenterological Association and Spanish Digestive Endoscopy Society	30366156	2019
32	Low Incidence of Advanced Neoplasia in Serrated Polyposis Syndrome After (Sub)total Colectomy: Results of a 5-Year International Prospective Cohort Study. ⁶¹	Bleijenberg AGC...Dekker E	31403493	2019
33	Endocuff-assisted colonoscopy for surveillance of serrated polyposis syndrome: a multicenter randomized controlled trial. ⁶¹	Rivero-Sanchez L...EndoCAR group from the Spanish Gastroenterology Association and the Spanish Society of Digestive Endoscopy	31174224	2019
34	Endoscopic control of polyp burden and expansion of surveillance intervals in serrated polyposis syndrome. ⁶¹	MacPhail ME...Rex DK	30465771	2019
35	Serrated polyposis syndrome: time to rethink endoscopic treatment and surveillance. ⁶¹	Pellise M...Balaguer F	31228973	2019
36	NTHL1 biallelic mutations seldom cause colorectal cancer, serrated polyposis or a multi-tumor phenotype, in absence of colorectal adenomas. ⁶¹	Belhadj S...Valle L	31227763	2019
37	Screening Relevance of Sessile Serrated Polyps. ⁶¹	Kahi CJ	30625264	2019
38	BRAF mutation: Current and future clinical pathological applications in colorectal carcinoma. ⁶¹	Ng JY...Lam AK	30592501	2019
39	High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors. ⁶¹	Rigter LS...van Leerdam ME	30561773	2019
40	Reasons why the diagnosis of serrated polyposis syndrome is missed. ⁶¹	van Herwaarden YJ...Nagtegaal ID	30520764	2019
41	Diagnosis of Serrated Polyposis Syndrome in an Adolescent Patient. ⁶¹	Daniel R...Pall H	30428696	2019
42	[French comment on article High incidence of advanced colorectal neoplasia during endoscopic surveillance in serrated polyposis syndrome]. ⁶¹		30695810	2019
43	High incidence of advanced colorectal neoplasia during endoscopic surveillance in serrated polyposis syndrome. ⁶¹	Rodriguez-Alcalde D...Gastrointestinal Oncology Group of the Spanish Gastroenterological Association	30068004	2019
44	An Update on Inherited Colon Cancer and Gastrointestinal Polyposis. ⁶¹	Plevova P	31409085	2019
45	Aspects of the Natural History of Sessile Serrated Adenomas/Polyps: Risk Indicators for Carcinogenesis in the Colorectal Mucosa? ⁶¹	Neary PM...Church JM	30346367	2018
46	Evidence suggests that germline RNF43 mutations are a rare cause of serrated polyposis. ⁶¹	Quintana I...Valle L	29330307	2018
47	[French comment on article The clinical significance and synchronous polyp burden of large (≥ 20mm) sessile serrated polyps in patients without serrated polyposis syndrome]. ⁶¹		30399638	2018
48	The clinical significance and synchronous polyp burden of large (≥ 20 mm) sessile serrated polyps in patients without serrated polyposis syndrome. ⁶¹	Desomer L...Bourke MJ	29739023	2018
49	Adenocarcinoma of the anal canal with an exceptional immunohistochemistry in a patient with serrated polyposis syndrome: a diagnostic challenge. ⁶¹	Ruano Campos A...Fernandez Acenero MJ	30168336	2018
50	Serrated polyposis syndrome may go undiagnosed even in structured colorectal cancer screening programmes performed by endoscopists with otherwise good quality indices. ⁶¹	Schramm C...Steffen HM	29055909	2018

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Genes for Serrated Polyposis Syndrome

Genes related to Serrated Polyposis Syndrome (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	RNF43	Ring Finger Protein 43	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	27081527 24512911
2	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	400	Pathogenic ⁶
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
4	FBLN2	Fibulin 2	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
5	GREM1	Gremlin 1, DAN Family BMP Antagonist	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
7	MUTYH	MutY DNA Glycosylase	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
8	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)

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Variations for Serrated Polyposis Syndrome

ClinVar genetic disease variations for Serrated Polyposis Syndrome:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	RNF43	NM_001305545.1(RNF43):c.-45C>T	SNV	Pathogenic	254140	rs1567880628	GRCh37: 17:56448310-56448310 GRCh38: 17:58370949-58370949
2	RNF43	NM_017763.5(RNF43):c.394C>T (p.Arg132Ter)	SNV	Pathogenic	190226	rs786205215	GRCh37: 17:56440943-56440943 GRCh38: 17:58363582-58363582
3	APC	NM_000038.6(APC):c.3922_3926AAAGA[1] (p.Glu1309fs)	Microsatellite	Pathogenic	816	rs121913224	GRCh37: 5:112175212-112175216 GRCh38: 5:112839515-112839519
4	RNF43	NM_017763.6(RNF43):c.1976dup (p.Pro660fs)	Duplication	Pathogenic	1031999		GRCh37: 17:56435160-56435161 GRCh38: 17:58357799-58357800

Copy number variations for Serrated Polyposis Syndrome from CNVD:

⁷

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	121765	18	46810580	46865409	Pathogenic mutation c.1264_1265delinsa	SMAD4	Serrated polyposis

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Expression for Serrated Polyposis Syndrome

Search GEO for disease gene expression data for Serrated Polyposis Syndrome.

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Pathways for Serrated Polyposis Syndrome

Pathways related to Serrated Polyposis Syndrome according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.5	PTEN KRAS BRAF APC
2	Pathways in cancer ³⁶	12.43	PTEN KRAS BRAF APC
3	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.29	PTEN KRAS BRAF APC
4	MicroRNAs in cancer ³⁶	12.26	PTEN KRAS APC
5	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.13	PTEN KRAS BRAF
6	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.09	PTEN KRAS BRAF APC
7	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	11.96	PTEN KRAS BRAF
8	Colorectal Cancer Metastasis ⁶³	11.89	KRAS BRAF APC
9	EGF/EGFR Signaling Pathway ¹	11.87	PTEN KRAS BRAF
10	Integrated Breast Cancer Pathway ¹	11.8	PTEN KRAS BRAF
11	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	11.73	PTEN KRAS BRAF APC
12	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.68	PTEN KRAS BRAF
13	DNA Damage Response (only ATM dependent) ¹	11.49	PTEN KRAS APC
14	Copper homeostasis ¹	11.34	PTEN APC
15	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.22	KRAS BRAF
16	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.16	KRAS BRAF
17	Ovarian tumor domain proteases ⁶⁵	11.14	PTEN APC
18	BDNF-TrkB Signaling ¹	11.07	KRAS BRAF
19	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.01	PTEN KRAS
20	Extracellular vesicle-mediated signaling in recipient cells ¹	11	KRAS APC
21	Glioblastoma Multiforme ⁶³	10.97	PTEN KRAS BRAF APC
22	G-protein signaling_K-RAS regulation pathway ²³	10.94	KRAS BRAF

Sources

GO Terms for Serrated Polyposis Syndrome

Biological processes related to Serrated Polyposis Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	long-term synaptic potentiation	GO:0060291	9.4	PTEN BRAF
2	visual learning	GO:0008542	9.37	KRAS BRAF
3	cellular response to nerve growth factor stimulus	GO:1990090	9.32	PTEN BRAF
4	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.26	PTEN APC
5	endothelial cell migration	GO:0043542	9.16	PTEN GREM1
6	regulation of synaptic transmission, GABAergic	GO:0032228	8.96	PTEN KRAS
7	regulation of axon regeneration	GO:0048679	8.62	PTEN BRAF

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Sources for Serrated Polyposis Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁶ DrugBank

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²⁰ GARD

²¹ GeneAnalytics

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²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Serrated Polyposis Syndrome

Aliases & Classifications for Serrated Polyposis Syndrome

MalaCards integrated aliases for Serrated Polyposis Syndrome:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Serrated Polyposis Syndrome

Related Diseases for Serrated Polyposis Syndrome

Diseases related to Serrated Polyposis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Serrated Polyposis Syndrome:

Symptoms & Phenotypes for Serrated Polyposis Syndrome

Human phenotypes related to Serrated Polyposis Syndrome:

GenomeRNAi Phenotypes related to Serrated Polyposis Syndrome according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Serrated Polyposis Syndrome:

Drugs & Therapeutics for Serrated Polyposis Syndrome

Drugs for Serrated Polyposis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Serrated Polyposis Syndrome

Anatomical Context for Serrated Polyposis Syndrome

MalaCards organs/tissues related to Serrated Polyposis Syndrome:

Publications for Serrated Polyposis Syndrome

Articles related to Serrated Polyposis Syndrome:

Genes for Serrated Polyposis Syndrome

Genes related to Serrated Polyposis Syndrome (2 elite genes):

Variations for Serrated Polyposis Syndrome

ClinVar genetic disease variations for Serrated Polyposis Syndrome:

Copy number variations for Serrated Polyposis Syndrome from CNVD:

Expression for Serrated Polyposis Syndrome

Pathways for Serrated Polyposis Syndrome

Pathways related to Serrated Polyposis Syndrome according to GeneCards Suite gene sharing:

GO Terms for Serrated Polyposis Syndrome

Biological processes related to Serrated Polyposis Syndrome according to GeneCards Suite gene sharing:

Sources for Serrated Polyposis Syndrome