MCID: SRT002
MIFTS: 32

Sertoli Cell Tumor

Categories: Cancer diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Sertoli Cell Tumor

MalaCards integrated aliases for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 12 55 44 15 73
Tubular Androblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3577
MeSH 44 D012707
NCIt 50 C39976
UMLS 73 C0036769

Summaries for Sertoli Cell Tumor

MalaCards based summary : Sertoli Cell Tumor, also known as tubular androblastoma, is related to frasier syndrome and sex cord-gonadal stromal tumor. An important gene associated with Sertoli Cell Tumor is SYP (Synaptophysin), and among its related pathways/superpathways is Ovarian Infertility Genes. Affiliated tissues include testis, ovary and testes, and related phenotype is normal.

Related Diseases for Sertoli Cell Tumor

Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 frasier syndrome 29.7 NR5A1 WT1
2 sex cord-gonadal stromal tumor 28.5 CALB2 INHA NR5A1 SYP WT1
3 malignant sertoli cell tumor 12.3
4 carney complex, type 1 11.0
5 gynandroblastoma 10.6 CALB2 VIM
6 granular cell tumor 10.6 INHA VIM
7 fallopian tube carcinosarcoma 10.6 CALB2 WT1
8 spindle cell liposarcoma 10.5 CALB2 WT1
9 malignant biphasic mesothelioma 10.5 CALB2 WT1
10 pneumatosis cystoides intestinalis 10.5 CALB2 WT1
11 metanephric adenoma 10.5 VIM WT1
12 pleural cancer 10.5 CALB2 WT1
13 dysgerminoma of ovary 10.4 CALB2 WT1
14 primary hepatic neuroendocrine carcinoma 10.4 SYP VIM
15 rhabdoid meningioma 10.4 SYP VIM
16 astroblastoma 10.4 SYP VIM
17 melanotic neuroectodermal tumor 10.4 SYP VIM
18 angiocentric glioma 10.4 SYP VIM
19 medulloepithelioma 10.4 SYP VIM
20 functional colonic disease 10.4 CALB2 SYP
21 microcystic adenoma 10.4 INHA MUC1
22 peritoneal serous adenocarcinoma 10.4 SYP WT1
23 46,xy partial gonadal dysgenesis 10.4 NR5A1 WT1
24 horseshoe kidney 10.4 CALB2 SYP
25 glomus tumor 10.4 SYP VIM
26 cauda equina neoplasm 10.4 SYP WT1
27 ovarian brenner tumor 10.4 CALB2 WT1
28 mucinous bronchioloalveolar adenocarcinoma 10.4 CALB2 MUC1
29 peutz-jeghers syndrome 10.3
30 bile duct cystadenocarcinoma 10.3 CALB2 MUC1
31 colonic pseudo-obstruction 10.3 CALB2 SYP
32 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.3 INHA SYP
33 malignant peritoneal mesothelioma 10.3 MUC1 VIM
34 parachordoma 10.3 MUC1 VIM
35 ossifying fibromyxoid tumor 10.3 MUC1 VIM
36 fibrous meningioma 10.3 MUC1 VIM
37 malignant mixed mullerian tumor 10.3 MUC1 VIM
38 nodular hidradenoma 10.3 MUC1 VIM
39 syringocystadenoma papilliferum 10.3 MUC1 VIM
40 eccrine porocarcinoma 10.3 MUC1 VIM
41 endometrial mucinous adenocarcinoma 10.3 MUC1 VIM
42 biphasic synovial sarcoma 10.3 MUC1 VIM
43 myxopapillary ependymoma 10.3 MUC1 VIM
44 ovarian mucinous neoplasm 10.3 SYP WT1
45 monophasic synovial sarcoma 10.3 MUC1 VIM
46 spiradenoma 10.3 MUC1 VIM
47 syringoma 10.3 MUC1 VIM
48 denys-drash syndrome 10.3 NR5A1 WT1
49 hidradenoma 10.3 MUC1 VIM
50 reticulum cell sarcoma 10.3 MUC1 VIM

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 CALB2 INHA NR5A1 PRKAR1A SYP WT1

Drugs & Therapeutics for Sertoli Cell Tumor

Search Clinical Trials , NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

MalaCards organs/tissues related to Sertoli Cell Tumor:

41
Testis, Ovary, Testes, Bone, Prostate, Bone Marrow, Lung

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 197)
# Title Authors Year
1
Prepubertal Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis. ( 29626571 )
2018
2
Estrogen-induced myelotoxicity in a 4-year-old golden retriever dog due to a Sertoli cell tumor. ( 29606731 )
2018
3
Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report. ( 29915800 )
2018
4
Testis-sparing surgery of unilateral testicular large-cell calcifying Sertoli cell tumor: a sporadic case. ( 29799406 )
2018
5
Mayer-Rokitansky-KA1ster-Hauser Syndrome With Bilateral Ovarian Sertoli Cell Tumors: Review of the Literature and Report of a Rare Case. ( 28922305 )
2017
6
An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report. ( 28276158 )
2017
7
Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome. ( 28386495 )
2017
8
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome. ( 26621753 )
2016
9
LARGE CELL CALCIFYING SERTOLI CELL TUMOR OF THE TESTIS: A CASE REPORT. ( 28740051 )
2016
10
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. ( 27510681 )
2016
11
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. ( 27873740 )
2016
12
A CASE OF AN AROMATASE-PRODUCING SERTOLI CELL TUMOR PRESENTING WITH GYNECOMASTIA. ( 28442671 )
2016
13
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
14
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. ( 26933269 )
2016
15
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. ( 26989303 )
2016
16
A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor. ( 26366315 )
2015
17
Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex. ( 26587565 )
2015
18
What is your diagnosis? Cryptorchidism and Sertoli cell tumor. ( 25970213 )
2015
19
Nuclear Localization of I^-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases. ( 26034868 )
2015
20
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
21
Melanotic Sertoli cell tumor. ( 25007144 )
2014
22
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome. ( 25171448 )
2014
23
Frequent mutation and nuclear localization of I^-catenin in sertoli cell tumors of the testis. ( 24061522 )
2014
24
Testicular sclerosing sertoli cell tumor: a case report and review of the literature. ( 25548547 )
2014
25
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. ( 25025367 )
2014
26
Sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases. ( 24552667 )
2014
27
Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature. ( 24627695 )
2014
28
Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age. ( 25226294 )
2014
29
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. ( 23412916 )
2013
30
Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. ( 23329316 )
2013
31
Sclerosing Sertoli cell tumor of the testis: a case report with review of the literature. ( 24228134 )
2013
32
What is your diagnosis? Sertoli cell tumor with multiorgan metastasis. ( 23409440 )
2012
33
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. ( 22908070 )
2012
34
Organ-sparing surgery of the bilateral testicular large cell calcifying sertoli cell tumor in patient with atypical Peutz-Jeghers syndrome. ( 22160729 )
2012
35
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. ( 25191441 )
2012
36
Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. ( 22226390 )
2012
37
Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. ( 22876554 )
2012
38
Testicular sclerosing Sertoli cell tumor: an additional case and review of the literature. ( 23155292 )
2012
39
Pathology in practice: Sertoli cell tumor (SCT). ( 22720987 )
2012
40
Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus). ( 23397858 )
2012
41
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. ( 22705745 )
2012
42
Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis. ( 23090627 )
2012
43
An unusual cause of infantile gynecomastia: sertoli cell tumor. ( 21358339 )
2011
44
Spontaneous sertoli cell tumor with cryptorchism in a beagle dog. ( 21826179 )
2011
45
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
46
Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. ( 20736766 )
2010
47
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. ( 20587845 )
2010
48
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. ( 20004940 )
2010
49
Acute abdomen due to rupture of Sertoli cell tumor. ( 19597832 )
2010
50
Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. ( 21170861 )
2010

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 INHA NR5A1

GO Terms for Sertoli Cell Tumor

Cellular components related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuromuscular junction GO:0031594 8.62 PRKAR1A SYP

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 INHA NR5A1 WT1
2 SMAD protein signal transduction GO:0060395 9.4 INHA VIM
3 tissue development GO:0009888 9.37 NR5A1 WT1
4 adrenal gland development GO:0030325 9.32 NR5A1 WT1
5 positive regulation of male gonad development GO:2000020 9.16 NR5A1 WT1
6 sex determination GO:0007530 8.96 NR5A1 WT1
7 negative regulation of female gonad development GO:2000195 8.62 NR5A1 WT1

Sources for Sertoli Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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