MCID: SRT002
MIFTS: 31

Sertoli Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Sertoli Cell Tumor

MalaCards integrated aliases for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 12 55 44 15 73
Tubular Androblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3577
MeSH 44 D012707
NCIt 50 C39976
SNOMED-CT 68 89089007
UMLS 73 C0036769

Summaries for Sertoli Cell Tumor

MalaCards based summary : Sertoli Cell Tumor, also known as tubular androblastoma, is related to sex cord-gonadal stromal tumor and malignant sertoli cell tumor. An important gene associated with Sertoli Cell Tumor is SYP (Synaptophysin), and among its related pathways/superpathways is Ovarian Infertility Genes. Affiliated tissues include testis, ovary and prostate, and related phenotypes are neoplasm and normal

Related Diseases for Sertoli Cell Tumor

Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 sex cord-gonadal stromal tumor 29.5 CALB2 INHA PGR SYP WT1
2 malignant sertoli cell tumor 12.5
3 carney complex, type 1 11.2
4 peutz-jeghers syndrome 10.5
5 gynecomastia 10.3
6 seminoma 10.2
7 gynandroblastoma 10.2 CALB2 VIM
8 fallopian tube carcinosarcoma 10.2 CALB2 WT1
9 androgen insensitivity syndrome 10.2
10 granular cell tumor 10.2 INHA VIM
11 reproductive organ benign neoplasm 10.2 CALB2 PGR
12 malignant biphasic mesothelioma 10.2 CALB2 WT1
13 mixed germ cell-sex cord neoplasm 10.2 CALB2 WT1
14 spindle cell liposarcoma 10.2 CALB2 WT1
15 sarcomatoid mesothelioma 10.1 VIM WT1
16 metanephric adenoma 10.1 VIM WT1
17 lymphangiomatosis 10.1 PGR VIM
18 primary hepatic neuroendocrine carcinoma 10.1 SYP VIM
19 pneumatosis cystoides intestinalis 10.1 CALB2 WT1
20 epulis 10.1 PGR VIM
21 pleural cancer 10.1 CALB2 WT1
22 benign breast phyllodes tumor 10.1 PGR VIM
23 benign metastasizing leiomyoma 10.1 PGR VIM
24 astroblastoma 10.1 SYP VIM
25 angiocentric glioma 10.1 SYP VIM
26 peritoneal serous adenocarcinoma 10.1 SYP WT1
27 microcystic adenoma 10.1 INHA MUC1
28 functional colonic disease 10.1 CALB2 SYP
29 medulloepithelioma 10.1 SYP VIM
30 giant cell tumor 10.1 MUC1 VIM
31 cauda equina neoplasm 10.1 SYP WT1
32 glomus tumor 10.1 SYP VIM
33 testicular torsion 10.1
34 gonadoblastoma 10.1
35 carney complex variant 10.1
36 adenocarcinoma 10.1
37 adenoma 10.1
38 bile duct cystadenocarcinoma 10.1 CALB2 MUC1
39 female reproductive endometrioid cancer 10.1 PGR WT1
40 horseshoe kidney 10.1 CALB2 SYP
41 rhabdoid cancer 10.1 SYP WT1
42 malignant peritoneal mesothelioma 10.1 MUC1 VIM
43 parachordoma 10.1 MUC1 VIM
44 secretory meningioma 10.1 MUC1 VIM
45 syringocystadenoma papilliferum 10.1 MUC1 VIM
46 smooth muscle tumor 10.1 PGR VIM
47 ossifying fibromyxoid tumor 10.1 MUC1 VIM
48 fibrous meningioma 10.1 MUC1 VIM
49 nodular hidradenoma 10.1 MUC1 VIM
50 hidradenoma 10.1 MUC1 VIM

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 INHA PGR PRKAR1A WT1
2 normal MP:0002873 9.1 CALB2 INHA PGR PRKAR1A SYP WT1

Drugs & Therapeutics for Sertoli Cell Tumor

Search Clinical Trials , NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

MalaCards organs/tissues related to Sertoli Cell Tumor:

41
Testis, Ovary, Prostate, Kidney, Colon, Smooth Muscle, Thymus

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 186)
# Title Authors Year
1
Prepubertal Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis. ( 29626571 )
2018
2
Estrogen-induced myelotoxicity in a 4-year-old golden retriever dog due to a Sertoli cell tumor. ( 29606731 )
2018
3
Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report. ( 29915800 )
2018
4
Testis-sparing surgery of unilateral testicular large-cell calcifying Sertoli cell tumor: a sporadic case. ( 29799406 )
2018
5
Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis. ( 30303161 )
2018
6
An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report. ( 28276158 )
2017
7
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome. ( 26621753 )
2016
8
LARGE CELL CALCIFYING SERTOLI CELL TUMOR OF THE TESTIS: A CASE REPORT. ( 28740051 )
2016
9
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. ( 27510681 )
2016
10
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. ( 27873740 )
2016
11
A CASE OF AN AROMATASE-PRODUCING SERTOLI CELL TUMOR PRESENTING WITH GYNECOMASTIA. ( 28442671 )
2016
12
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
13
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. ( 26933269 )
2016
14
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. ( 26989303 )
2016
15
A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor. ( 26366315 )
2015
16
Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex. ( 26587565 )
2015
17
What is your diagnosis? Cryptorchidism and Sertoli cell tumor. ( 25970213 )
2015
18
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
19
Melanotic Sertoli cell tumor. ( 25007144 )
2014
20
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome. ( 25171448 )
2014
21
Testicular sclerosing sertoli cell tumor: a case report and review of the literature. ( 25548547 )
2014
22
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. ( 25025367 )
2014
23
Sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases. ( 24552667 )
2014
24
Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature. ( 24627695 )
2014
25
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. ( 23412916 )
2013
26
Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. ( 23329316 )
2013
27
Sclerosing Sertoli cell tumor of the testis: a case report with review of the literature. ( 24228134 )
2013
28
What is your diagnosis? Sertoli cell tumor with multiorgan metastasis. ( 23409440 )
2012
29
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. ( 22908070 )
2012
30
Organ-sparing surgery of the bilateral testicular large cell calcifying sertoli cell tumor in patient with atypical Peutz-Jeghers syndrome. ( 22160729 )
2012
31
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. ( 25191441 )
2012
32
Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. ( 22226390 )
2012
33
Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. ( 22876554 )
2012
34
Testicular sclerosing Sertoli cell tumor: an additional case and review of the literature. ( 23155292 )
2012
35
Pathology in practice: Sertoli cell tumor (SCT). ( 22720987 )
2012
36
Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus). ( 23397858 )
2012
37
An unusual cause of infantile gynecomastia: sertoli cell tumor. ( 21358339 )
2011
38
Spontaneous sertoli cell tumor with cryptorchism in a beagle dog. ( 21826179 )
2011
39
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
40
Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. ( 20736766 )
2010
41
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. ( 20587845 )
2010
42
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. ( 20004940 )
2010
43
Acute abdomen due to rupture of Sertoli cell tumor. ( 19597832 )
2010
44
Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. ( 21170861 )
2010
45
Pure Sertoli cell tumor. a case report and review of the literature. ( 20349797 )
2010
46
[A case of sertoli cell tumor with arteriovenous malformation]. ( 20104012 )
2010
47
Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. ( 19553598 )
2009
48
A case of persistent MA1llerian duct syndrome with sertoli cell tumor and hydrometra in a dog. ( 19346713 )
2009
49
Sertoli cell tumor of the testis: a case with late metastasis. ( 18500567 )
2008
50
[Case report of malignant sertoli cell tumor]. ( 18697473 )
2008

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 INHA PGR

GO Terms for Sertoli Cell Tumor

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD protein signal transduction GO:0060395 8.62 INHA VIM

Sources for Sertoli Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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