MCID: SRT002
MIFTS: 38

Sertoli Cell Tumor

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Sertoli Cell Tumor

MalaCards integrated aliases for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 11 53 43 14 71
Tubular Androblastoma 11

Classifications:



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Disease Ontology 11 DOID:3577
MeSH 43 D012707
NCIt 49 C39976
SNOMED-CT 68 128857001
UMLS 71 C0036769

Summaries for Sertoli Cell Tumor

Disease Ontology: 11 A sex cord-gonadal stromal tumor characterized by excessive proliferation of Sertoli cells.

MalaCards based summary: Sertoli Cell Tumor, also known as tubular androblastoma, is related to testicular cancer and androgen insensitivity syndrome. An important gene associated with Sertoli Cell Tumor is CALB2 (Calbindin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and COPI-independent Golgi-to-ER retrograde traffic. The drugs Nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testes, and related phenotypes are no effect and no effect

Related Diseases for Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 539)
# Related Disease Score Top Affiliating Genes
1 testicular cancer 31.1 CGB3 CALB2 AR AFP
2 androgen insensitivity syndrome 30.6 NR5A1 MUC1 AR
3 peutz-jeghers syndrome 30.6 TGFBR2 PRKAR1A INHA CYP19A1
4 gynecomastia 30.6 PGR INHA CYP19A1 AR
5 gonadoblastoma 30.4 WT1 NR5A1 CGB3 AFP
6 carcinoid tumors, intestinal 30.3 SYP ENO2
7 germinoma 30.3 INHA CGB3 AFP
8 renal adenoma 30.2 WT1 KRT7
9 polycystic liver disease 1 with or without kidney cysts 30.1 MUC1 KRT7 CALB2
10 gonadal dysgenesis 30.1 WT1 NR5A1 CGB3
11 carcinoid syndrome 30.1 SYP ENO2
12 complete androgen insensitivity syndrome 30.0 NR5A1 CYP19A1 AR
13 seminoma 30.0 INHA ENO2 CGB3 AR AFP
14 cryptorchidism, unilateral or bilateral 29.9 WT1 NR5A1 CYP19A1 AR AFP
15 adenoma 29.9 TGFBR2 SYP PRKAR1A MUC1 KRT7
16 leydig cell tumor 29.9 SYP NR5A1 INHA CYP19A1 CALB2 AFP
17 large cell neuroendocrine carcinoma 29.6 SYP KRT7 ENO2
18 germ cell cancer 29.6 ENO2 AR AFP
19 pseudohermaphroditism 29.5 WT1 NR5A1 CYP19A1 AR
20 46,xy sex reversal 29.5 WT1 NR5A1 CYP19A1 AR
21 sarcoma 29.5 WT1 VIM MUC1 ENO2 CALB2
22 carcinosarcoma 29.3 WT1 VIM SYP PGR MUC1 KRT7
23 pheochromocytoma 29.3 VIM SYP KRT7 ENO2 CALB2
24 adrenal cortical adenoma 29.3 SYP PRKAR1A NR5A1 INHA ENO2
25 inguinal hernia 29.2 WT1 TGFBR2 NR5A1 CALB2 AR AFP
26 dysgerminoma 29.2 WT1 MUC1 KRT7 INHA ENO2 AFP
27 disorder of sexual development 29.1 WT1 PGR NR5A1 CYP19A1 AR AFP
28 neuroendocrine carcinoma 29.0 SYP PGR MUC1 KRT7 ENO2 AFP
29 sertoli-leydig cell tumor 28.8 WT1 VIM SYP PGR MUC1 KRT7
30 wilms tumor 1 28.8 WT1 SYP PGR NR5A1 MUC1 KRT7
31 teratoma 28.7 VIM SYP MUC1 KRT7 ENO2 CGB3
32 endometrial cancer 28.7 WT1 TGFBR2 PGR MUC1 KRT7 INHA
33 sex cord-gonadal stromal tumor 28.4 WT1 VIM PRKAR1A PGR NR5A1 MUC1
34 ovarian cancer 27.8 WT1 VIM TGFBR2 PGR MUC1 KRT8
35 prostate cancer 27.3 VIM TGFBR2 PGR MUC1 KRT8 INHA
36 carney complex, type 1 11.2
37 rare tumor 10.5
38 carney complex variant 10.5
39 malignant sertoli-leydig cell tumor of the ovary 10.4
40 testicular germ cell tumor 10.4
41 ovarian wilms' cancer 10.4 WT1 CALB2
42 fallopian tube carcinosarcoma 10.4 WT1 CALB2
43 peritoneal serous adenocarcinoma 10.4 WT1 CALB2
44 parovarian cyst 10.4 INHA AFP
45 fallopian tube adenocarcinoma 10.4 WT1 CALB2
46 liver fibroma 10.4 VIM CALB2
47 scott syndrome 10.4
48 syndrome with 46,xy disorder of sex development 10.4
49 infected hydrocele 10.3 CALB2 AFP
50 chromosomal triplication 10.3 CGB3 AFP

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

GenomeRNAi Phenotypes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.05 AFP AR CALB2 CGB3 CYP19A1 ENO2
2 no effect GR00402-S-2 10.05 AR CALB2 CYP19A1 INHA KRT7 MUC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.86 AFP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.86 KRT8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.86 KRT7 KRT8
6 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.86 KRT8
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.86 AFP KRT7 KRT8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.86 KRT8
9 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.86 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.86 KRT7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.86 KRT7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.86 KRT7 KRT8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.86 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.86 KRT7

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 AFP AR CGB3 CYP19A1 INHA KRT7
2 normal MP:0002873 10.27 AR CALB2 CYP19A1 INHA MUC1 NR5A1
3 endocrine/exocrine gland MP:0005379 10.14 AFP AR CGB3 CYP19A1 INHA MUC1
4 neoplasm MP:0002006 10.11 AFP AR INHA MUC1 PGR PRKAR1A
5 liver/biliary system MP:0005370 10.11 AFP AR CYP19A1 INHA KRT8 MUC1
6 cellular MP:0005384 10.03 AR CGB3 CYP19A1 ENO2 INHA KRT7
7 muscle MP:0005369 10.02 AR CYP19A1 PGR PRKAR1A TGFBR2 VIM
8 embryo MP:0005380 9.97 AR KRT8 NR5A1 PGR PRKAR1A TGFBR2
9 digestive/alimentary MP:0005381 9.87 AR CYP19A1 INHA KRT8 MUC1 PRKAR1A
10 cardiovascular system MP:0005385 9.85 AR CYP19A1 INHA KRT8 NR5A1 PGR
11 behavior/neurological MP:0005386 9.73 AFP AR CALB2 CYP19A1 ENO2 KRT8
12 reproductive system MP:0005389 9.36 AFP AR CGB3 CYP19A1 INHA KRT8

Drugs & Therapeutics for Sertoli Cell Tumor

Drugs for Sertoli Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Antineoplastic Agents, Immunological Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antibodies Phase 2
6 Immunoglobulins Phase 2
7 Immune Checkpoint Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC) Recruiting NCT03866382 Phase 2 Cabozantinib S-malate

Search NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

Organs/tissues related to Sertoli Cell Tumor:

MalaCards : Testis, Ovary, Testes, Bone Marrow, Thyroid, Bone, Uterus

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 396)
# Title Authors PMID Year
1
Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. 53 62
19033865 2009
2
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. 53 62
17721194 2007
3
Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. 53 62
15644771 2005
4
Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha. 53 62
15363041 2004
5
A(870)E mutation of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and Sertoli cell tumor. 53 62
9332480 1997
6
Sertoli Cell Tumor of Testes in a Child with Peutz-Jeghers syndrome. 53 62
18417782 1997
7
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis. 62
35778792 2022
8
Sertoli cell tumor in patient with multiple intratesticular cysts. 62
35832857 2022
9
Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amenable to specific histopathologic subclassification. 62
36180576 2022
10
Sex cord stromal tumors and tumors of the paratestis: new and old entities in a landscape of rare tumors. 62
35749781 2022
11
Sex cord stromal tumors and tumors of the paratestis: new and old entities in a landscape of rare tumors. 62
35749732 2022
12
Testicular Lesions in Infertile Men. 62
34935941 2022
13
Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features. 62
34913878 2022
14
Pure Sertoli cell tumor of the ovary: A case report. 62
35620254 2022
15
Canine testicular tumors: An 11-year retrospective study of 358 cases in Moscow Region, Russia. 62
35400936 2022
16
[Clinical Characterization of Patients with Ovarian Mass Combined with Dysplasia of Secondary Sexual Characteristics]. 62
35300760 2022
17
Peutz-Jeghers syndrome: Skin manifestations and endocrine anomalies (Review). 62
34650635 2021
18
Thoracic Sertoli-Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation. 62
34398502 2021
19
[Diagnosis and treatment of rare testicular tumors using the example of malignant mesothelioma of the tunica vaginalis testis and Sertoli cell tumors]. 62
34185119 2021
20
Prepubertal gynecomastia is not always idiopathic: case series and review of the literature. 62
32975593 2021
21
Complete androgen insensitivity syndrome with accelerated onset of puberty due to a Sertoli cell tumor. 62
33867670 2021
22
[SERTOLI CELL TUMOR OF TESTIS: CASE REPORT]. 62
35858810 2021
23
Mixed granulosa-Sertoli sex cord-stromal tumor of the testis: clinical, ultrasonic and histopathological features: a case report. 62
33457255 2020
24
Sertoli cell tumor/mixed germ cell-stromal cell tumor as separate neoplasms in a bilaterally cryptorchid dog. 62
32879527 2020
25
NSE positive Sertoli cell tumor of the testis: case report and literature review. 62
32703482 2020
26
Anaplastic Sarcoma and Sertoli Cell Tumor in a Central Bearded Dragon (Pogona vitticeps). 62
33633500 2020
27
Be cautious of "complex hydrocele" on ultrasound in young men. 62
32255327 2020
28
Sertoli Cell Tumor With Ossification and Adipose Tissue Differentiation. 62
31311370 2020
29
An Unusual Presentation of Carney Complex 62
31117334 2020
30
Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis. 62
32257489 2020
31
Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article. 62
33076667 2020
32
The sclerosing Sertoli cell tumor of the testis is an extremely rare entity. 62
33193816 2020
33
Sertoli Cell Tumor (SCT) in a Captive Black Bear (Ursus americanus). 62
31561583 2019
34
Phenotype evolution and health issues of adults with Beckwith-Wiedemann syndrome. 62
31339634 2019
35
Somatic PRKAR1A Gene Mutation in a Nonsyndromic Metastatic Large Cell Calcifying Sertoli Cell Tumor. 62
31286102 2019
36
Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization. 62
29949388 2019
37
Persistent Mullerian duct Syndrome in a Brazilian miniature schnauzer dog. 62
31241703 2019
38
Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor. 62
31137577 2019
39
[Organ-sparing partial orchietectomy for testicular adenomatoid tumor]. 62
30996385 2019
40
INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors. 62
29084059 2019
41
Metastatic testicular Sertoli cell tumor in a free-ranging cryptorchid adult spotted seal Phoca largha in North Slope, Alaska, USA. 62
30997879 2019
42
Ovarian Sex Cord-stromal Tumors With Melanin Pigment: Report of a Previously Undescribed Phenomenon. 62
29140884 2019
43
Sonographic diagnosis of large-cell calcifying Sertoli cell tumor. 62
31355590 2019
44
Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis. 62
30303161 2018
45
[Clinicopathologic and molecular characterizations of Sertoli cell tumor, not otherwise specified of the testis]. 62
29996314 2018
46
Prepubertal Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis. 62
29626571 2018
47
Malignant Female Adnexal Tumor of Probable Wolffian Origin: Case Report and Literature Review. 62
28700436 2018
48
Solitary Fibrous Tumors in Pediatric Patients: A Rare and Potentially Overdiagnosed Neoplasm, Confirmed by STAT6 Immunohistochemistry. 62
29228868 2018
49
Testis-sparing surgery of unilateral testicular large-cell calcifying Sertoli cell tumor: a sporadic case. 62
29799406 2018
50
Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report. 62
29915800 2018

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.05 VIM MUC1 KRT8 KRT7
2
Show member pathways
11.84 VIM PGR KRT8 KRT7 AR
3
Show member pathways
11.62 PGR NR5A1 AR
4 11.19 WT1 VIM KRT8
5 10.44 VIM PGR
6 10.42 PGR NR5A1 INHA CYP19A1

GO Terms for Sertoli Cell Tumor

Cellular components related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.1 VIM KRT8 KRT7

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD protein signal transduction GO:0060395 9.88 VIM INHA AFP
2 male gonad development GO:0008584 9.76 WT1 NR5A1 INHA AR
3 ovulation from ovarian follicle GO:0001542 9.73 PGR AFP
4 positive regulation of male gonad development GO:2000020 9.67 WT1 NR5A1
5 prostate gland growth GO:0060736 9.62 CYP19A1 AR
6 sex determination GO:0007530 9.56 WT1 NR5A1
7 negative regulation of female gonad development GO:2000195 9.26 WT1 NR5A1
8 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.92 PGR AR

Molecular functions related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 9.1 PGR NR5A1 AR

Sources for Sertoli Cell Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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