MCID: SRT002
MIFTS: 38

Sertoli Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Sertoli Cell Tumor

MalaCards integrated aliases for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 12 54 44 15 71
Tubular Androblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3577
MeSH 44 D012707
NCIt 50 C39976
SNOMED-CT 67 89089007
UMLS 71 C0036769

Summaries for Sertoli Cell Tumor

Disease Ontology : 12 A sex cord-gonadal stromal tumor characterized by excessive proliferation of Sertoli cells.

MalaCards based summary : Sertoli Cell Tumor, also known as tubular androblastoma, is related to peutz-jeghers syndrome and gynecomastia. An important gene associated with Sertoli Cell Tumor is CALB2 (Calbindin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Ipilimumab and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 534)
# Related Disease Score Top Affiliating Genes
1 peutz-jeghers syndrome 30.7 PRKAR1A INHA CYP19A1
2 gynecomastia 30.7 PGR INHA CYP19A1 AR
3 androgen insensitivity syndrome 30.5 NR5A1 MUC1 AR
4 adenoma 30.3 SYP PRKAR1A MUC1 KRT7
5 carcinoid syndrome 30.3 SYP ENO2
6 renal adenoma 30.3 WT1 KRT7
7 gonadoblastoma 30.1 WT1 NR5A1 ALPP
8 spindle cell sarcoma 30.1 VIM MUC1 KRT7
9 carcinoid tumors, intestinal 30.1 SYP ENO2
10 seminoma 30.0 INHA ENO2 ALPP AFP
11 ovarian germ cell teratoma 30.0 SYP KRT7 CALB2 AFP
12 complete androgen insensitivity syndrome 30.0 MUC1 CYP19A1 AR
13 leydig cell tumor 30.0 SYP NR5A1 INHA CYP19A1 CALB2 AFP
14 germinoma 29.9 INHA ALPP AFP
15 large cell neuroendocrine carcinoma 29.8 SYP KRT7 ENO2
16 testicular cancer 29.8 ENO2 AR ALPP AFP
17 primary pigmented nodular adrenocortical disease 29.8 SYP PRKAR1A PGR CYP19A1
18 carcinosarcoma 29.7 VIM PGR MUC1 KRT7 CALB2
19 neuroendocrine carcinoma 29.6 SYP MUC1 KRT7 ENO2
20 disorder of sexual development 29.6 WT1 NR5A1 CYP19A1 AR
21 pseudohermaphroditism 29.6 WT1 NR5A1 CYP19A1 AR
22 46,xy sex reversal 29.6 WT1 NR5A1 CYP19A1 AR
23 teratoma 29.5 SYP KRT7 ENO2 CALB2 AFP
24 adrenal cortical adenoma 29.5 SYP PRKAR1A NR5A1 INHA ENO2
25 pheochromocytoma 29.4 VIM SYP KRT7 ENO2 CALB2
26 infertility 29.3 PGR NR5A1 INHA CYP19A1 AR
27 cryptorchidism, unilateral or bilateral 29.1 WT1 NR5A1 CYP19A1 AR ALPP AFP
28 dysgerminoma 28.9 WT1 KRT7 INHA ENO2 ALPP AFP
29 endometrial cancer 28.7 WT1 PGR MUC1 KRT7 INHA CYP19A1
30 wilms tumor 1 28.5 WT1 VIM PGR NR5A1 MUC1 KRT7
31 sertoli-leydig cell tumor 28.4 WT1 SYP PGR MUC1 KRT7 INHA
32 sex cord-gonadal stromal tumor 28.1 WT1 VIM PRKAR1A PGR NR5A1 MUC1
33 carney complex, type 1 11.2
34 infant gynecomastia 10.6
35 rare tumor 10.5
36 carney complex variant 10.5
37 fallopian tube carcinosarcoma 10.4 WT1 CALB2
38 gynandroblastoma 10.4 VIM CALB2
39 dermoid cyst of ovary 10.4 CALB2 AFP
40 spermatocele 10.4 CALB2 AFP
41 infected hydrocele 10.4 CALB2 AFP
42 adrenogenital syndrome 10.4 SYP INHA
43 liver fibroma 10.4 VIM CALB2
44 thymus sarcomatoid carcinoma 10.4 SYP AFP
45 papillary thymic adenocarcinoma 10.4 SYP CALB2
46 peritoneal benign neoplasm 10.4 PGR CALB2
47 glomangiomyoma 10.4 VIM SYP
48 cervical clear cell adenocarcinoma 10.4 PGR AFP
49 ovarian mixed germ cell neoplasm 10.4 WT1 AFP
50 cervical serous adenocarcinoma 10.4 WT1 PGR

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

GenomeRNAi Phenotypes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.28 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.28 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.28 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.28 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.28 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.28 AFP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.28 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.28 AFP

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.8 AFP AR CYP19A1 INHA KRT8 PRKAR1A
2 normal MP:0002873 9.65 AR CALB2 CYP19A1 INHA NR5A1 PGR
3 neoplasm MP:0002006 9.63 AFP AR INHA PGR PRKAR1A WT1
4 reproductive system MP:0005389 9.32 AFP AR CYP19A1 INHA KRT8 NR5A1

Drugs & Therapeutics for Sertoli Cell Tumor

Drugs for Sertoli Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ipilimumab Approved Phase 2 477202-00-9
2
nivolumab Approved Phase 2 946414-94-4
3 Antineoplastic Agents, Immunological Phase 2
4 Immunoglobulins Phase 2
5 Antibodies, Monoclonal Phase 2
6 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC) Recruiting NCT03866382 Phase 2 Cabozantinib S-malate

Search NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

MalaCards organs/tissues related to Sertoli Cell Tumor:

40
Testis, Ovary, Testes, Bone Marrow, Thyroid, Kidney, Pancreas

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 377)
# Title Authors PMID Year
1
Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. 61 54
19033865 2009
2
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. 54 61
17721194 2007
3
Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. 61 54
15644771 2005
4
Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha. 54 61
15363041 2004
5
A(870)E mutation of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and Sertoli cell tumor. 54 61
9332480 1997
6
Sertoli Cell Tumor of Testes in a Child with Peutz-Jeghers syndrome. 61 54
18417782 1997
7
Prepubertal gynecomastia is not always idiopathic: case series and review of the literature. 61
32975593 2021
8
Mixed granulosa-Sertoli sex cord-stromal tumor of the testis: clinical, ultrasonic and histopathological features: a case report. 61
33457255 2020
9
Sertoli cell tumor/mixed germ cell-stromal cell tumor as separate neoplasms in a bilaterally cryptorchid dog. 61
32879527 2020
10
NSE positive Sertoli cell tumor of the testis: case report and literature review. 61
32703482 2020
11
Sertoli Cell Tumor With Ossification and Adipose Tissue Differentiation. 61
31311370 2020
12
Be cautious of "complex hydrocele" on ultrasound in young men. 61
32255327 2020
13
An Unusual Presentation of Carney Complex 61
31117334 2020
14
Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article. 61
33076667 2020
15
Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis. 61
32257489 2020
16
The sclerosing Sertoli cell tumor of the testis is an extremely rare entity. 61
33193816 2020
17
Sertoli Cell Tumor (SCT) in a Captive Black Bear (Ursus americanus). 61
31561583 2019
18
Phenotype evolution and health issues of adults with Beckwith-Wiedemann syndrome. 61
31339634 2019
19
Somatic PRKAR1A Gene Mutation in a Nonsyndromic Metastatic Large Cell Calcifying Sertoli Cell Tumor. 61
31286102 2019
20
Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization. 61
29949388 2019
21
Persistent Mullerian duct Syndrome in a Brazilian miniature schnauzer dog. 61
31241703 2019
22
Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor. 61
31137577 2019
23
[Organ-sparing partial orchietectomy for testicular adenomatoid tumor]. 61
30996385 2019
24
INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors. 61
29084059 2019
25
Metastatic testicular Sertoli cell tumor in a free-ranging cryptorchid adult spotted seal Phoca largha in North Slope, Alaska, USA. 61
30997879 2019
26
Ovarian Sex Cord-stromal Tumors With Melanin Pigment: Report of a Previously Undescribed Phenomenon. 61
29140884 2019
27
Sonographic diagnosis of large-cell calcifying Sertoli cell tumor. 61
31355590 2019
28
Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis. 61
30303161 2018
29
[Clinicopathologic and molecular characterizations of Sertoli cell tumor, not otherwise specified of the testis]. 61
29996314 2018
30
Prepubertal Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis. 61
29626571 2018
31
Malignant Female Adnexal Tumor of Probable Wolffian Origin: Case Report and Literature Review. 61
28700436 2018
32
Solitary Fibrous Tumors in Pediatric Patients: A Rare and Potentially Overdiagnosed Neoplasm, Confirmed by STAT6 Immunohistochemistry. 61
29228868 2018
33
Testis-sparing surgery of unilateral testicular large-cell calcifying Sertoli cell tumor: a sporadic case. 61
29799406 2018
34
Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report. 61
29915800 2018
35
Estrogen-induced myelotoxicity in a 4-year-old golden retriever dog due to a Sertoli cell tumor. 61
29606731 2018
36
Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases. 61
29222199 2018
37
Benign Large-cell Calcifying Sertoli Tumor of the Testis in a 13-Year-Old Male Patient Treated With Partial Orchiectomy. 61
28551172 2017
38
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. 61
27488929 2017
39
Unusual presentations of Carney Complex in patient with a novel PRKAR1A mutation. 61
28871709 2017
40
An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report. 61
28276158 2017
41
Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms. 61
28445692 2017
42
A Hard Ball for a Tennis Player: A Rare Case of Large Calcifying Sertoli Cell Testicular Tumor. 61
28480167 2017
43
Response to Anastrozole Treatment in a Case with Peutz-Jeghers Syndrome and a Large Cell Calcifying Sertoli Cell Tumor. 61
27873740 2017
44
Surgical Therapy of 17α-hydroxylase Deficiency in 30 Patients. 61
27825414 2016
45
Prepubertal testicular tumors: a single-center experience of 44years. 61
26987710 2016
46
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. 61
27510681 2016
47
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome. 61
26621753 2016
48
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. 61
26933269 2016
49
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. 61
26989303 2016
50
LARGE CELL CALCIFYING SERTOLI CELL TUMOR OF THE TESTIS: A CASE REPORT. 61
28740051 2016

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.11 VIM MUC1 KRT8 KRT7
2
Show member pathways
11.58 VIM KRT8 KRT7
3
Show member pathways
11.39 PGR NR5A1 AR
4 11.38 WT1 VIM ALPP AFP
5 11.2 WT1 VIM KRT8
6 10.43 PGR NR5A1 INHA CYP19A1

GO Terms for Sertoli Cell Tumor

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD protein signal transduction GO:0060395 9.5 VIM INHA AFP
2 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 PGR AR
3 positive regulation of male gonad development GO:2000020 9.4 WT1 NR5A1
4 sex determination GO:0007530 9.37 WT1 NR5A1
5 ovulation from ovarian follicle GO:0001542 9.26 PGR AFP
6 negative regulation of female gonad development GO:2000195 9.16 WT1 NR5A1
7 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.96 PGR AR
8 male gonad development GO:0008584 8.92 WT1 NR5A1 INHA AR

Molecular functions related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.63 WT1 PGR NR5A1 AR ALPP AFP
2 RNA polymerase II transcription coactivator binding GO:0001225 8.96 PGR AR
3 nuclear receptor activity GO:0004879 8.8 PGR NR5A1 AR

Sources for Sertoli Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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