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MCID: SRT003
MIFTS: 39

Sertoli-Leydig Cell Tumor

Categories: Rare diseases, Cancer diseases, Reproductive diseases, Endocrine diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sertoli-Leydig Cell Tumor

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MalaCards integrated aliases for Sertoli-Leydig Cell Tumor:

Name: Sertoli-Leydig Cell Tumor 12 55 44 15 73
Sertoli-Leydig Cell Tumor of Intermediate Differentiation 73
Sertoli-Leydig Cell Tumor of the Ovary 53
Sertoli-Leydig Cell Tumor of Ovary 73
Sertoli-Leydig Cell Tumors 53
Arrhenoblastoma of Ovary 53
Androblastoma of Ovary 53
Arrhenoblastoma 53

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2997
MeSH 44 D018310
SNOMED-CT 68 34110004
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Summaries for Sertoli-Leydig Cell Tumor

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NIH Rare Diseases : 53 Sertoli-Leydig celltumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. Sertoli-Leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women. Treatment involves surgery and chemotherapy or radiation if the cancer has spread. Because Sertoli-Leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good.

MalaCards based summary : Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of intermediate differentiation, is related to gynandroblastoma and rete testis adenocarcinoma, and has symptoms including hoarseness An important gene associated with Sertoli-Leydig Cell Tumor is AFP (Alpha Fetoprotein). The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and testis, and related phenotype is neoplasm.

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Related Diseases for Sertoli-Leydig Cell Tumor

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Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 31.2 CALB2 DICER1
2 rete testis adenocarcinoma 30.8 AFP CALB2
3 endodermal sinus tumor 30.3 AFP KRT7
4 desmoplastic small round cell tumor 29.9 MUC1 WT1
5 mucinous adenocarcinoma 29.7 KRT7 MUC1
6 teratoma 29.7 AFP KRT7
7 cystadenoma 29.3 KRT7 MUC1 PGR
8 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.8
9 malignant sertoli-leydig cell tumor of the ovary 12.5
10 malignant sertoli-leydig cell tumor 12.3
11 leydig cell tumor 11.1
12 kidney sarcoma 10.5 DICER1 WT1
13 pineoblastoma 10.5 AFP DICER1
14 fallopian tube carcinosarcoma 10.5 CALB2 WT1
15 rete testis neoplasm 10.5 AFP CALB2
16 venous hemangioma 10.4 CALB2 WT1
17 mixed hepatoblastoma 10.4 AFP PGR
18 spindle cell liposarcoma 10.4 CALB2 WT1
19 spermatocele 10.4 CALB2 PGR
20 pneumatosis cystoides intestinalis 10.4 CALB2 WT1
21 androgen insensitivity syndrome 10.4
22 rhabdomyosarcoma 10.4
23 pleural cancer 10.4 CALB2 WT1
24 nephrotic syndrome, type 1 10.3 AFP WT1
25 pleomorphic lipoma 10.3 CALB2 PGR
26 kidney benign neoplasm 10.3 DICER1 KRT7
27 multinodular goiter 10.3
28 goiter 10.3
29 complete androgen insensitivity syndrome 10.3
30 malignant leydig cell tumor 10.3 CALB2 KRT7
31 atypical choroid plexus papilloma 10.3 DICER1 KRT7
32 intrahepatic bile duct adenoma 10.3 AFP KRT7
33 renal pelvis adenocarcinoma 10.3 AFP KRT7
34 ovarian germ cell cancer 10.3 AFP KRT7
35 intratubular embryonal carcinoma 10.3 AFP KRT7
36 clear cell adenofibroma 10.3 CALB2 KRT7
37 sarcoma 10.3
38 amenorrhea 10.3
39 cervicitis 10.3
40 adenocarcinoma 10.3
41 choriocarcinoma of the testis 10.2 AFP KRT7
42 seminal vesicle tumor 10.2 AFP KRT7
43 ovarian endodermal sinus tumor 10.2 AFP KRT7
44 horseshoe kidney 10.2 CALB2 KRT7
45 renal adenoma 10.2 KRT7 WT1
46 cribriform carcinoma 10.2 KRT7 PGR
47 oncocytic breast carcinoma 10.2 KRT7 PGR
48 benign metastasizing leiomyoma 10.2 KRT7 PGR
49 epithelial predominant wilms' tumor 10.2 KRT7 WT1
50 pericardium cancer 10.2 CALB2 KRT7

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to Sertoli-Leydig Cell Tumor
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Symptoms & Phenotypes for Sertoli-Leydig Cell Tumor

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UMLS symptoms related to Sertoli-Leydig Cell Tumor:


hoarseness

MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AFP DICER1 PGR WT1
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Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

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Drugs for Sertoli-Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
5
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
6
Etoposide Approved Phase 2 33419-42-0 36462
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Angiogenesis Inhibitors Phase 2
11 Angiogenesis Modulating Agents Phase 2
12 Antibodies Phase 2
13 Antibodies, Monoclonal Phase 2
14 Endothelial Growth Factors Phase 2
15 Immunoglobulin G Phase 2
16 Immunoglobulins Phase 2
17 Mitogens Phase 2
18 Anti-Bacterial Agents Phase 2
19 Antibiotics, Antitubercular Phase 2
20 Etoposide phosphate Phase 2
21 Topoisomerase Inhibitors Phase 2
22
Gemcitabine Approved Phase 1 95058-81-4 60750
23 Anti-Infective Agents Phase 1
24 Antimetabolites Phase 1
25 Antimetabolites, Antineoplastic Phase 1
26 Antiviral Agents Phase 1
27 Immunosuppressive Agents Phase 1
28
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
29
Dactinomycin Approved, Investigational 50-76-0 2019 457193
30
Doxorubicin Approved, Investigational 23214-92-8 31703
31
Ifosfamide Approved 3778-73-2 3690
32
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
33
Doxil Approved June 1999 31703
34
Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
3 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789 Not Applicable
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
9 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Sertoli-Leydig Cell Tumor

Cochrane evidence based reviews: sertoli-leydig cell tumor

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Genetic Tests for Sertoli-Leydig Cell Tumor

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Anatomical Context for Sertoli-Leydig Cell Tumor

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MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

41
Ovary, Endothelial, Testis, Testes, Uterus, Thyroid, Skeletal Muscle
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Publications for Sertoli-Leydig Cell Tumor

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Articles related to Sertoli-Leydig Cell Tumor:

(show top 50) (show all 145)
# Title Authors Year
1
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
2
Poorly differentiated, ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcoma and glandular elements: Diagnosis and management of a rare neoplasm. ( 29922708 )
2018
3
Case report: an identical twin with Sertoli-Leydig cell tumor. ( 29366348 )
2018
4
Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element. ( 29620585 )
2018
5
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
6
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
7
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors. ( 28654427 )
2017
8
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
9
Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall. ( 29081925 )
2017
10
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects. ( 27664536 )
2017
11
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
12
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
13
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
14
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
15
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
16
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
17
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
18
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
19
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
20
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
21
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
22
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
23
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
24
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
25
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
26
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
27
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
28
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
29
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
30
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
31
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
32
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
33
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
34
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. ( 23173550 )
2013
35
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. ( 22691037 )
2013
36
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. ( 24328002 )
2013
37
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. ( 22102529 )
2013
38
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013
39
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. ( 23878752 )
2013
40
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. ( 23276568 )
2012
41
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. ( 22808364 )
2012
42
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. ( 22633001 )
2012
43
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. ( 23084689 )
2012
44
Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern. ( 22443217 )
2012
45
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. ( 22635079 )
2012
46
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. ( 21847587 )
2012
47
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. ( 21205968 )
2011
48
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. ( 21623193 )
2011
49
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. ( 21347632 )
2011
50
Cytologic, immunocytologic, histopathologic and immunohistologic diagnosis of the poorly differentiated sertoli-leydig cell tumor. ( 21791911 )
2011
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Variations for Sertoli-Leydig Cell Tumor

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Expression for Sertoli-Leydig Cell Tumor

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Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.
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Pathways for Sertoli-Leydig Cell Tumor

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GO Terms for Sertoli-Leydig Cell Tumor

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Cellular components related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 AFP CALB2 DICER1 KRT7 MUC1 PGR

Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR
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Sources for Sertoli-Leydig Cell Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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