Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SRT003
MIFTS: 37

Sertoli-Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Sertoli-Leydig Cell Tumor

About this section

MalaCards integrated aliases for Sertoli-Leydig Cell Tumor:

Name: Sertoli-Leydig Cell Tumor 12 55 44 15 73
Sertoli-Leydig Cell Tumor of Intermediate Differentiation 73
Sertoli-Leydig Cell Tumor of the Ovary 53
Sertoli-Leydig Cell Tumor of Ovary 73
Sertoli-Leydig Cell Tumors 53
Arrhenoblastoma of Ovary 53
Androblastoma of Ovary 53
Arrhenoblastoma 53

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2997
MeSH 44 D018310
SNOMED-CT 68 34110004
Sources

Summaries for Sertoli-Leydig Cell Tumor

About this section
NIH Rare Diseases : 53 Sertoli-Leydig celltumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. Sertoli-Leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women. Treatment involves surgery and chemotherapy or radiation if the cancer has spread. Because Sertoli-Leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good.

MalaCards based summary : Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of intermediate differentiation, is related to leydig cell tumor and gynandroblastoma, and has symptoms including hoarseness An important gene associated with Sertoli-Leydig Cell Tumor is AFP (Alpha Fetoprotein). The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and lung, and related phenotype is neoplasm.

Sources

Related Diseases for Sertoli-Leydig Cell Tumor

About this section

Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 31.9 AFP INSL3
2 gynandroblastoma 30.8 CALB2 DICER1
3 mucinous adenocarcinoma 30.6 KRT7 MUC1
4 rete testis adenocarcinoma 30.5 AFP CALB2
5 teratoma 30.5 AFP KRT7
6 cystadenoma 30.5 KRT7 MUC1 PGR
7 desmoplastic small round cell tumor 30.3 MUC1 WT1
8 cystadenocarcinoma 29.9 KRT7 MUC1 PGR
9 dysgerminoma 29.9 AFP KRT7 MUC1 WT1
10 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.9
11 malignant sertoli-leydig cell tumor of the ovary 12.6
12 malignant sertoli-leydig cell tumor 12.5
13 rhabdomyosarcoma 10.6
14 androgen insensitivity syndrome 10.5
15 multinodular goiter 10.5
16 goiter 10.5
17 complete androgen insensitivity syndrome 10.5
18 sarcoma 10.4
19 amenorrhea 10.4
20 adenocarcinoma 10.4
21 hyperandrogenism 10.3
22 adenoma 10.3
23 dicer1-related disorders 10.3
24 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 10.3
25 uterine anomalies 10.2 AFP PGR
26 pineoblastoma 10.2 AFP DICER1
27 mixed hepatoblastoma 10.2 AFP PGR
28 biliary tract disease 10.2 AFP KRT7
29 peutz-jeghers syndrome 10.2
30 hematopoietic stem cell transplantation 10.2
31 leiomyoma 10.2
32 breast adenoma 10.2
33 endodermal sinus tumor 10.2
34 cystic teratoma 10.2
35 embryonal rhabdomyosarcoma 10.2
36 botryoid rhabdomyosarcoma 10.2
37 adrenal adenoma 10.2
38 granulosa cell tumor of the ovary 10.2
39 precocious puberty 10.2
40 kidney sarcoma 10.2 DICER1 WT1
41 rete testis neoplasm 10.2 AFP CALB2
42 intrahepatic bile duct adenoma 10.2 AFP KRT7
43 renal pelvis adenocarcinoma 10.2 AFP KRT7
44 ovarian germ cell cancer 10.2 AFP KRT7
45 intratubular embryonal carcinoma 10.1 AFP KRT7
46 fallopian tube carcinosarcoma 10.1 CALB2 WT1
47 sweat gland cancer 10.1 KRT7 PGR
48 cervical adenocarcinoma 10.1 KRT7 PGR
49 seminal vesicle tumor 10.1 AFP KRT7
50 choriocarcinoma of the testis 10.1 AFP KRT7

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to Sertoli-Leydig Cell Tumor
Sources

Symptoms & Phenotypes for Sertoli-Leydig Cell Tumor

About this section

UMLS symptoms related to Sertoli-Leydig Cell Tumor:


hoarseness

MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AFP DICER1 PGR WT1
Sources

Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

About this section

Drugs for Sertoli-Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
4
Etoposide Approved Phase 2 33419-42-0 36462
5
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
6
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
7 Antineoplastic Agents, Phytogenic Phase 2
8 Antimitotic Agents Phase 2
9 Albumin-Bound Paclitaxel Phase 2
10 Immunologic Factors Phase 2,Phase 1
11 Mitogens Phase 2
12 Immunoglobulin G Phase 2
13 Immunoglobulins Phase 2
14 Angiogenesis Modulating Agents Phase 2
15 Antibodies, Monoclonal Phase 2
16 Endothelial Growth Factors Phase 2
17 Angiogenesis Inhibitors Phase 2
18 Antibodies Phase 2
19 Anti-Bacterial Agents Phase 2
20 Etoposide phosphate Phase 2
21 Antibiotics, Antitubercular Phase 2
22 Topoisomerase Inhibitors Phase 2
23
Gemcitabine Approved Phase 1 95058-81-4 60750
24 Immunosuppressive Agents Phase 1
25 Antiviral Agents Phase 1
26 Antimetabolites, Antineoplastic Phase 1
27 Anti-Infective Agents Phase 1
28 Antimetabolites Phase 1
29
Dactinomycin Approved, Investigational 50-76-0 457193 2019
30
Cyclophosphamide Approved, Investigational 6055-19-2, 50-18-0 2907
31
Vincristine Approved, Investigational 57-22-7, 2068-78-2 5978
32
Ifosfamide Approved 3778-73-2 3690
33
Doxorubicin Approved, Investigational 23214-92-8 31703
34
Doxil Approved June 1999 31703
35
Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
3 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789 Not Applicable
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
9 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Sertoli-Leydig Cell Tumor

Cochrane evidence based reviews: sertoli-leydig cell tumor

Sources

Genetic Tests for Sertoli-Leydig Cell Tumor

About this section
Sources

Anatomical Context for Sertoli-Leydig Cell Tumor

About this section

MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

41
Ovary, Testis, Lung, Kidney, Liver, Prostate, Thymus
Sources

Publications for Sertoli-Leydig Cell Tumor

About this section

Articles related to Sertoli-Leydig Cell Tumor:

(show top 50) (show all 135)
# Title Authors Year
1
Poorly differentiated, ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcoma and glandular elements: Diagnosis and management of a rare neoplasm. ( 29922708 )
2018
2
Case report: an identical twin with Sertoli-Leydig cell tumor. ( 29366348 )
2018
3
Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element. ( 29620585 )
2018
4
Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome. ( 30014022 )
2018
5
Frozen Section Diagnostic Pitfalls of Sertoli-Leydig Cell Tumor with Heterologous Elements. ( 30147979 )
2018
6
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
7
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
8
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
9
Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall. ( 29081925 )
2017
10
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
11
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
12
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
13
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
14
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
15
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
16
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
17
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
18
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
19
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
20
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
21
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
22
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
23
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
24
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
25
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
26
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
27
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
28
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
29
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
30
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
31
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. ( 23173550 )
2013
32
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. ( 22691037 )
2013
33
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. ( 24328002 )
2013
34
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013
35
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. ( 23878752 )
2013
36
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. ( 23276568 )
2012
37
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. ( 22808364 )
2012
38
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. ( 22633001 )
2012
39
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. ( 23084689 )
2012
40
Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern. ( 22443217 )
2012
41
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. ( 21847587 )
2012
42
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. ( 22635079 )
2012
43
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. ( 21347632 )
2011
44
Cytologic, immunocytologic, histopathologic and immunohistologic diagnosis of the poorly differentiated sertoli-leydig cell tumor. ( 21791911 )
2011
45
Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review. ( 21919698 )
2011
46
Postpartum hemorrhage from ruptured Sertoli-Leydig cell tumor: a case report. ( 21043371 )
2010
47
Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements. ( 20407320 )
2010
48
Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. ( 19957213 )
2010
49
Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary. ( 19674851 )
2010
50
Metastatic rhabdomyosarcomatous elements, mimicking a primary sarcoma, in the omentum, from a poorly differentiated ovarian Sertoli-Leydig cell tumor in a young girl: an unusual presentation with a literature review. ( 19805972 )
2009
Sources

Variations for Sertoli-Leydig Cell Tumor

About this section
Sources

Expression for Sertoli-Leydig Cell Tumor

About this section
Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.
Sources

Pathways for Sertoli-Leydig Cell Tumor

About this section
Sources

GO Terms for Sertoli-Leydig Cell Tumor

About this section

Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR
Sources

Sources for Sertoli-Leydig Cell Tumor

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....