SARS
MCID: SVR001
MIFTS: 59

Severe Acute Respiratory Syndrome (SARS)

Categories: Blood diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Severe Acute Respiratory Syndrome

MalaCards integrated aliases for Severe Acute Respiratory Syndrome:

Name: Severe Acute Respiratory Syndrome 12 76 53 3 44 15 73
Sars 12 53 3
Sars-Cov Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2945
ICD10 33 J12.81 U04
ICD9CM 35 079.82
MeSH 44 D045169
NCIt 50 C85064
UMLS 73 C1175175

Summaries for Severe Acute Respiratory Syndrome

Disease Ontology : 12 A viral infectious disease that results in infection located in respiratory tract, has material basis in SARS coronavirus (SARS-CoV), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. The infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards based summary : Severe Acute Respiratory Syndrome, also known as sars, is related to sarcoidosis 1 and avian influenza, and has symptoms including fever, headache and hypoxia. An important gene associated with Severe Acute Respiratory Syndrome is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs tannic acid and Ritonavir have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related phenotype is immune system.

CDC : 3 This website is archived for historical purposes and is no longer being maintained or updated.

Wikipedia : 76 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Related Diseases for Severe Acute Respiratory Syndrome

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Severe Acute Respiratory Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 31.5 CCL2 IFNG TNF
2 avian influenza 30.2 CXCL10 CXCL8 TNF
3 noonan syndrome 3 30.1 IFNA1 IFNB1 IRF3
4 west nile virus 30.1 CD209 CLEC4M IFNA1 IRF3
5 pneumonia 30.0 CCL2 CCL5 CRP CXCL8 TNF
6 murray valley encephalitis 30.0 IFNA1 IFNB1
7 respiratory failure 29.8 CRP CXCL8 TNF
8 yellow fever 29.8 CCL2 CCL5 IFNB1
9 hemorrhagic fever 29.8 CD209 IFNG TNF
10 measles 29.7 CD209 IFNA1 IFNB1 IFNG STAT1
11 mycoplasma pneumoniae pneumonia 29.7 CRP IFNG TNF
12 influenza 29.6 CCL5 CXCL10 IFNA1 IFNB1 IFNG IRF3
13 crohn's colitis 29.6 CXCL8 IFNG TNF
14 pulmonary edema 29.6 CRP CXCL8 TNF
15 keratoconjunctivitis 29.6 CXCL8 IFNG TNF
16 cytomegalovirus infection 29.5 CCL2 CCL5 CXCL8 TNF
17 arthritis 29.5 CCL2 CXCL8 IFNG TNF
18 chagas disease 29.5 CCL2 CXCL8 IFNG TNF
19 encephalitis 29.5 CCL2 CCL5 CD209 CLEC4M CXCL10 IRF3
20 gastroenteritis 29.5 CRP CXCL8 IFNA1 TNF
21 myeloma, multiple 29.4 CRP CXCL8 IFNA1 TNF
22 trypanosomiasis 29.4 CCL2 CCL5 CXCL8 IFNG TNF
23 malaria 29.3 CCL2 CCL5 CRP CXCL10 CXCL8 IFNG
24 hepatitis c 29.0 CLEC4M CXCL10 IFNA1 IFNB1 IFNG IRF3
25 human immunodeficiency virus type 1 28.7 CCL2 CCL5 CD209 CLEC4M CXCL10 IFNG
26 mouth disease 28.7 CRP IFNA1 IFNG IRF3 MX1 STAT1
27 viral infectious disease 28.3 CCL5 CD209 CXCL10 CXCL8 IFNA1 IFNB1
28 neurodevelopmental disorder with microcephaly, ataxia, and seizures 11.5
29 sarcosinemia 11.4
30 epidemic typhus 11.3
31 microcephaly 11.2
32 arteriovenous malformations of the brain 11.0
33 autosomal recessive non-syndromic intellectual disability 11.0
34 acute respiratory coronavirus infection 10.5
35 denture stomatitis 10.3 CCL2 CXCL8
36 common wart 10.3 CD209 CXCL8
37 neurosyphilis 10.3 CXCL10 CXCL8
38 vulvovaginitis 10.3 CCL5 CXCL8
39 pyuria 10.2 CRP CXCL8
40 oral erosive lichen 10.2 IFNA1 IFNB1
41 fungal meningitis 10.2 CCL2 CXCL10 IFNG
42 hepatitis 10.2
43 trichosporonosis 10.2 IFNG TNF
44 chronic beryllium disease 10.2 IFNG TNF
45 proliferative glomerulonephritis 10.2 CCL2 CXCL10 IFNG
46 japanese spotted fever 10.2 CCL2 CRP CXCL10
47 null-cell leukemia 10.2 IFNA1 TNF
48 burns 10.2 CRP TNF
49 salpingitis 10.2 CRP TNF
50 ulceroglandular tularemia 10.2 CRP STAT1

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to Severe Acute Respiratory Syndrome

Symptoms & Phenotypes for Severe Acute Respiratory Syndrome

Symptoms:

12
  • fever
  • headache
  • hypoxia
  • dry cough
  • body aches

UMLS symptoms related to Severe Acute Respiratory Syndrome:


fever, pruritus, snoring, coughing

MGI Mouse Phenotypes related to Severe Acute Respiratory Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 ACE2 CCL2 CCL5 CLEC4M CRP CXCL10

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

Drugs for Severe Acute Respiratory Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 tannic acid Approved Phase 2, Phase 3
2
Ritonavir Approved, Investigational Phase 2, Phase 3,Not Applicable 155213-67-5 392622
3
Interferon beta-1b Approved Phase 2, Phase 3 145155-23-3
4
Lopinavir Approved Phase 2, Phase 3,Not Applicable 192725-17-0 92727
5
Benzocaine Approved, Investigational Phase 2, Phase 3 94-09-7, 1994-09-7 2337
6
Streptokinase Approved, Investigational Phase 3 9002-01-1
7
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
8 Adjuvants, Immunologic Phase 2, Phase 3,Phase 1
9 Antiviral Agents Phase 2, Phase 3,Not Applicable
10 Interferon-beta Phase 2, Phase 3
11 Anti-Infective Agents Phase 2, Phase 3,Not Applicable
12 Immunologic Factors Phase 2, Phase 3,Phase 1
13 HIV Protease Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
14 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Not Applicable
15
protease inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
16 Anti-HIV Agents Phase 2, Phase 3,Not Applicable
17 Anti-Retroviral Agents Phase 2, Phase 3,Not Applicable
18 interferons Phase 2, Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Not Applicable
20 Fibrinolytic Agents Phase 3
21 Calcium, Dietary Phase 3
22 Anticoagulants Phase 3
23 calcium heparin Phase 3
24 Interferon-alpha Phase 2
25
Sorbitol Approved Phase 1 50-70-4 5780
26
Glutamic Acid Approved, Nutraceutical Phase 1 56-86-0 33032
27 Vaccines Phase 1
28 Antibodies Phase 1
29 Paraproteins Phase 1
30 gamma-Globulins Phase 1
31 Immunoglobulins, Intravenous Phase 1
32 Immunoglobulins Phase 1
33 Myeloma Proteins Phase 1
34 Rho(D) Immune Globulin Phase 1
35 Somatomedin B Phase 1
36 Antibodies, Monoclonal Phase 1
37
Ribavirin Approved Not Applicable 36791-04-5 37542
38 Antimetabolites Not Applicable

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 MERS-CoV Infection tReated With A Combination of Lopinavir /Ritonavir and Interferon Beta-1b Unknown status NCT02845843 Phase 2, Phase 3 Combination of Lopinavir /Ritonavir and Interferon beta-1b;Placebo
2 Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS Completed NCT03465085 Phase 3 Unfractionated heparin;Streptokinase
3 Study of Alferon® LDO (Low Dose Oral) in Normal Volunteers Completed NCT00215826 Phase 2 Alferon LDO
4 Phase I Study of a Vaccine for Severe Acute Respiratory Syndrome (SARS) Completed NCT00099463 Phase 1 Vaccine;VRC-SRSDNA015-00-VP
5 Phase I, Open Label Dose Ranging Safety Study of GLS-5300 in Healthy Volunteers Completed NCT02670187 Phase 1
6 Safety, Tolerability, and Pharmacokinetics of SAB-301 in Healthy Adults Completed NCT02788188 Phase 1
7 Saudi Outcomes of ECMO-treated MERS-CoV Patients Completed NCT02627378 Phase 1
8 Safety and Immunogenicity of a Candidate MERS-CoV Vaccine (MERS001) Recruiting NCT03399578 Phase 1
9 A Safety, Tolerability, Pharmacokinetics and Immunogenicity Trial of Co-administered MERS-CoV Antibodies REGN3048 and REGN3051 Active, not recruiting NCT03301090 Phase 1
10 Safety, Tolerability and Immunogenicity of Vaccine Candidate MVA-MERS-S Active, not recruiting NCT03615911 Phase 1
11 Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study Withdrawn NCT01376765 Phase 1 Aluminum hydroxide adjuvant (Alhydrogel®)
12 SARS Coronavirus Vaccine (SARS-CoV) Withdrawn NCT00533741 Phase 1 Aluminum hydroxide;Placebo
13 A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome Unknown status NCT00578825 Not Applicable Lopinavir / Ritonavir plus Ribavirin
14 Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children Unknown status NCT00173563
15 Investigating Severe Acute Respiratory Syndrome (SARS) Completed NCT00066209
16 Contamination During Removal of Two Different Personal Protective Systems Completed NCT00150475 Not Applicable
17 Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome Completed NCT00173459
18 Collection of Convalescent SARS Plasma by Apheresis Completed NCT00342524
19 Seroprevalence of MERS-CoV IgG in Healthcare Workers Completed NCT02497885
20 Clinical Study of SARS in Children Completed NCT00173576
21 Respiratory Virus Outpatient Study (FLU 002 Plus) Completed NCT01056354
22 Collection and Testing of Respiratory Samples Completed NCT01302418
23 Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome Recruiting NCT03443102
24 Respiratory Virus Hospitalization Study (FLU 003 Plus) Recruiting NCT01056185
25 A Clinical Cohort Study of Pneumonia in Respiratory Intensive Care Unit Recruiting NCT02738645
26 Detect Novel Pathogens and Characterize Emerging Infections Recruiting NCT01979705
27 Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases Recruiting NCT01200953
28 Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure Recruiting NCT03225807
29 The Respiratory Protection Effectiveness Clinical Trial Active, not recruiting NCT01249625 Not Applicable
30 Collection of Plasma From People Who Recovered From or Were Vaccinated to Emerging Infectious Diseases Enrolling by invitation NCT02338986
31 Evaluation and Treatment of Severe Acute Respiratory Syndrome (SARS) Withdrawn NCT00073086
32 The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes Withdrawn NCT00172263 Not Applicable
33 SARS Survivor Evaluations Withdrawn NCT00523276

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Cochrane evidence based reviews: severe acute respiratory syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

Anatomical Context for Severe Acute Respiratory Syndrome

MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

41
Lung, T Cells, Testes, Skin, Bone, Brain, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Severe Acute Respiratory Syndrome:

19
Respiratory Tract

Publications for Severe Acute Respiratory Syndrome

Articles related to Severe Acute Respiratory Syndrome:

(show top 50) (show all 1887)
# Title Authors Year
1
Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteenA year follow-up. ( 29594456 )
2018
2
Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3. ( 29294448 )
2018
3
Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis. ( 29789363 )
2018
4
Correction to: Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR. ( 29273879 )
2018
5
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. ( 30301856 )
2018
6
Design of novel multi-epitope vaccines against Severe Acute respiratory syndrome validated through multistage molecular interaction and dynamics. ( 30457455 )
2018
7
A Comparison of China's Risk Communication in Response to SARS and H7N9 Using Principles Drawn From International Practice. ( 28974284 )
2018
8
NMR structure and localization of a large fragment of the SARS-CoV fusion protein: Implications in viral cell fusion. ( 28988778 )
2018
9
Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study. ( 29038024 )
2018
10
MERS, SARS and other coronaviruses as causes of pneumonia. ( 29052924 )
2018
11
Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions. ( 29089594 )
2018
12
Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs. ( 29197729 )
2018
13
Routes of transmission of influenza A H1N1, SARS CoV, and norovirus in air cabin: Comparative analyses. ( 29244221 )
2018
14
Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells. ( 29275820 )
2018
15
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes. ( 29289665 )
2018
16
Don't misrepresent link between bats and SARS. ( 29345663 )
2018
17
Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects. ( 29407994 )
2018
18
Structural model of the SARS coronavirus E channel in LMPG micelles. ( 29474890 )
2018
19
SARS-CoV related Betacoronavirus and diverse Alphacoronavirus members found in western old-world. ( 29482919 )
2018
20
Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China. ( 29500691 )
2018
21
SARS 2018 Meeting Abstracts. ( 29516489 )
2018
22
Axial complex and associated structures of the sea urchin Strongylocentrotus pallidus (Sars, G.O. 1871) (Echinodermata: Echinoidea). ( 29528140 )
2018
23
Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine. ( 29541941 )
2018
24
An evaluation of selected (Q)SARs/expert systems for predicting skin sensitisation potential. ( 29676182 )
2018
25
Invasion of a Holarctic planktonic cladoceran Daphnia galeata Sars (Crustacea: Cladocera) in the Lower Lakes of South Australia. ( 29690281 )
2018
26
New species of the genus Mesocletodes Sars, 1909 from the deep Gulf of California (Copepoda, Harpacticoida). ( 29706785 )
2018
27
Synthesis, fungicidal activity, structure-activity relationships (SARs) and density functional theory (DFT) studies of novel strobilurin analogues containing arylpyrazole rings. ( 29777123 )
2018
28
Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein. ( 29800727 )
2018
29
New species of Eurycletodes Sars, 1909 and Odiliacletodes Soyer, 1964 from the deep Gulf of California (Copepoda, Harpacticoida, Argestidae). ( 29899673 )
2018
30
Traditional and confocal descriptions of a new genus and two new species of deep water Cerviniinae Sars, 1903 from the Southern Atlantic and the Norwegian Sea: with a discussion on the use of digital media in taxonomy (Copepoda, Harpacticoida, Aegisthidae). ( 29930476 )
2018
31
(Q)SARs as Adaptations to REACH Information Requirements. ( 29934889 )
2018
32
KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. ( 29939458 )
2018
33
The Impacts on Health, Society, and Economy of SARS and H7N9 Outbreaks in China: A Case Comparison Study. ( 30050581 )
2018
34
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. ( 30102747 )
2018
35
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death. ( 30185776 )
2018
36
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity? ( 30189015 )
2018
37
Complemented Palindromic Small RNAs First Discovered from SARS Coronavirus. ( 30189613 )
2018
38
Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats. ( 30209269 )
2018
39
Structurally- and dynamically-driven allostery of the chymotrypsin-like proteases of SARS, Dengue and Zika viruses. ( 30217495 )
2018
40
Nonspecific stress response to temperature increase in Gammarus lacustris Sars with respect to oxygen-limited thermal tolerance concept. ( 30245929 )
2018
41
The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species. ( 30248143 )
2018
42
Flavonoids as P-gp inhibitors: a systematic review of SARs. ( 30277144 )
2018
43
Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission. ( 30310104 )
2018
44
The role of the hotel industry in the response to emerging epidemics: a case study of SARS in 2003 and H1N1 swine flu in 2009 in Hong Kong. ( 30482214 )
2018
45
Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins. ( 30531999 )
2018
46
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-I^ antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation. ( 28591694 )
2017
47
Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). ( 28159163 )
2017
48
Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. ( 28373583 )
2017
49
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. ( 28148787 )
2017
50
No. 225-Management Guidelines for Obstetric Patients and Neonates Born to Mothers With Suspected or Probable Severe Acute Respiratory Syndrome (SARS). ( 28729104 )
2017

Variations for Severe Acute Respiratory Syndrome

Expression for Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for Severe Acute Respiratory Syndrome

Pathways related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CCL2 CCL5 CD209 CRP CTSL CXCL10
2
Show member pathways
13.66 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
3
Show member pathways
13.53 CCL2 CCL5 CXCL8 IFNA1 IFNB1 IFNG
4
Show member pathways
13.28 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
5
Show member pathways
13.06 CCL2 CCL5 CXCL8 IFNA1 IFNB1 IRF3
6
Show member pathways
13 IFNA1 IFNB1 IRF3 MX1 STAT1 TNF
7
Show member pathways
12.89 CTSL CXCL8 IFNA1 IFNG STAT1 TNF
8
Show member pathways
12.87 CCL2 CCL5 CXCL10 CXCL8 STAT1
9
Show member pathways
12.76 CCL5 CXCL10 CXCL8 IFNA1 IFNB1 IFNG
10
Show member pathways
12.57 IFNA1 IFNB1 IFNG IRF3 MX1 STAT1
11
Show member pathways
12.56 CCL2 IFNG STAT1 TNF
12
Show member pathways
12.51 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
13
Show member pathways
12.5 IFNA1 IFNB1 IFNG TNF
14 12.44 CCL2 CCL5 CXCL10 IFNA1 IFNG IRF3
15
Show member pathways
12.38 IFNA1 IFNB1 IFNG STAT1
16
Show member pathways
12.37 CCL2 CCL5 CRP IFNG TNF
17
Show member pathways
12.36 CCL2 CXCL10 CXCL8 IFNG TNF
18
Show member pathways
12.35 CXCL8 IFNG IRF3 STAT1 TNF
19 12.33 CXCL10 IFNA1 IFNB1 IRF3 STAT1 TNF
20
Show member pathways
12.31 IFNA1 IFNB1 IFNG STAT1
21
Show member pathways
12.27 CXCL8 IFNB1 IRF3 TNF
22
Show member pathways
12.24 IFNA1 IFNB1 IFNG STAT1 TNF
23
Show member pathways
12.23 CD209 CLEC4M STAT1 TNF
24
Show member pathways
12.18 CXCL8 IFNA1 IFNB1 IFNG IRF3 MX1
25
Show member pathways
12.16 CCL2 CCL5 CD209 CLEC4M CXCL10 CXCL8
26 12.12 CCL2 CTSL IFNG TNF
27
Show member pathways
12.09 CCL2 CCL5 CXCL8 IFNG STAT1
28 12.08 IFNB1 IFNG STAT1 TNF
29 12.07 CXCL8 IFNA1 IFNB1 IRF3 STAT1 TNF
30 12.06 CCL2 CXCL10 CXCL8 IFNG TNF
31 12.05 CD209 CLEC4M IFNA1 IFNB1 IFNG STAT1
32
Show member pathways
12.02 CCL2 CCL5 CXCL10 CXCL8
33 12.01 CCL2 CXCL8 STAT1 TNF
34 12 CCL2 CCL5 CXCL10 IFNB1 TNF
35 11.97 CD209 IFNG TNF
36 11.94 CCL2 CXCL8 STAT1 TNF
37 11.92 CXCL8 IFNB1 IFNG
38
Show member pathways
11.92 CTSL CXCL10 CXCL8 IFNB1 IFNG STAT1
39 11.91 IFNA1 IFNB1 IFNG STAT1
40 11.87 CXCL8 IFNG TNF
41 11.84 CCL2 CCL5 CTSL CXCL8 IFNG TNF
42 11.8 CXCL8 IFNG STAT1
43 11.79 CD209 IFNB1 IFNG TNF
44
Show member pathways
11.76 CXCL8 IFNG TNF
45 11.76 CXCL8 IRF3 TNF
46 11.76 CCL2 CCL5 CXCL10 IFNG TNF
47 11.71 CCL2 CCL5 CXCL8 TNF
48
Show member pathways
11.68 CXCL8 IFNG TNF
49 11.63 IFNG STAT1 TNF
50 11.58 CCL2 CXCL8 IFNG TNF

GO Terms for Severe Acute Respiratory Syndrome

Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ACE2 CCL2 CCL5 CRP CTSL CXCL10
2 extracellular region GO:0005576 9.47 ACE2 CCL2 CCL5 CD209 CLEC4M CRP
3 host cell GO:0043657 9.16 CD209 CLEC4M

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.99 CCL2 CXCL10 IFNB1 IFNG
2 adaptive immune response GO:0002250 9.95 CD209 CLEC4M CTSL IFNA1 IFNB1 IFNG
3 chemotaxis GO:0006935 9.94 CCL2 CCL5 CXCL10 CXCL8
4 response to bacterium GO:0009617 9.89 CCL2 CXCL10 IRF3
5 cellular response to lipopolysaccharide GO:0071222 9.89 CCL2 CXCL10 CXCL8 IRF3 TNF
6 cellular response to interferon-gamma GO:0071346 9.88 CCL2 CCL5 STAT1
7 cell chemotaxis GO:0060326 9.87 CCL2 CCL5 CXCL10
8 viral entry into host cell GO:0046718 9.86 ACE2 CD209 CLEC4M
9 neutrophil chemotaxis GO:0030593 9.86 CCL2 CCL5 CXCL10 CXCL8
10 regulation of signaling receptor activity GO:0010469 9.86 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
11 cellular response to interleukin-1 GO:0071347 9.85 CCL2 CCL5 CXCL8
12 interferon-gamma-mediated signaling pathway GO:0060333 9.85 IFNG IRF3 STAT1
13 chemokine-mediated signaling pathway GO:0070098 9.85 CCL2 CCL5 CXCL10 CXCL8
14 regulation of insulin secretion GO:0050796 9.84 CCL5 IFNG TNF
15 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 CCL5 STAT1 TNF
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 CCL5 STAT1 TNF
17 antigen processing and presentation GO:0019882 9.81 CD209 CLEC4M CTSL
18 protein kinase B signaling GO:0043491 9.81 CCL2 CCL5 TNF
19 type I interferon signaling pathway GO:0060337 9.8 IFNA1 IFNB1 IRF3 MX1 STAT1
20 defense response GO:0006952 9.8 CXCL10 CXCL8 IFNA1 IFNB1 MX1 TNF
21 response to exogenous dsRNA GO:0043330 9.79 IFNA1 IFNB1 IRF3
22 cellular response to fibroblast growth factor stimulus GO:0044344 9.78 CCL2 CCL5 CXCL8
23 leukocyte cell-cell adhesion GO:0007159 9.77 CCL5 CD209 CLEC4M
24 humoral immune response GO:0006959 9.77 CCL2 IFNA1 IFNB1 IFNG TNF
25 negative regulation of viral genome replication GO:0045071 9.76 CCL5 IFNB1 MX1 TNF
26 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.74 IFNA1 IFNB1 IFNG
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 CCL2 CCL5 IRF3 TNF
28 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
29 positive regulation of monocyte chemotaxis GO:0090026 9.72 CCL5 CXCL10
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG TNF
31 positive regulation of T cell migration GO:2000406 9.71 CCL5 CXCL10
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 STAT1
33 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
34 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.7 CCL5 CXCL8
35 positive regulation of interferon-alpha production GO:0032727 9.7 IRF3 STAT1
36 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.7 IFNG STAT1
37 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
38 viral genome replication GO:0019079 9.69 CCL2 CD209 CLEC4M
39 intracellular transport of virus GO:0075733 9.68 CD209 CLEC4M
40 neutrophil activation GO:0042119 9.68 CCL5 CXCL8
41 negative regulation of lipid storage GO:0010888 9.67 CRP TNF
42 modulation by virus of host morphology or physiology GO:0019048 9.66 CD209 CLEC4M
43 cell-cell recognition GO:0009988 9.65 CD209 CLEC4M
44 virion attachment to host cell GO:0019062 9.65 CD209 CLEC4M
45 peptide antigen transport GO:0046968 9.63 CD209 CLEC4M
46 response to virus GO:0009615 9.63 CCL5 CXCL10 IFNB1 IFNG MX1 TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IFNG TNF
48 receptor biosynthetic process GO:0032800 9.62 ACE2 TNF
49 macrophage apoptotic process GO:0071888 9.59 CTSL IRF3
50 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 IFNG TNF

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 CCL5 CRP IRF3 MX1 STAT1 TNF
2 virus receptor activity GO:0001618 9.5 ACE2 CD209 CLEC4M
3 type I interferon receptor binding GO:0005132 9.4 IFNA1 IFNB1
4 virion binding GO:0046790 9.33 CD209 CLEC4M CRP
5 CCR5 chemokine receptor binding GO:0031730 9.26 CCL5 STAT1
6 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8
7 cytokine activity GO:0005125 9.23 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1

Sources for Severe Acute Respiratory Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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