MCID: SVR001
MIFTS: 57

Severe Acute Respiratory Syndrome

Categories: Rare diseases, Infectious diseases, Respiratory diseases, Fetal diseases

Aliases & Classifications for Severe Acute Respiratory Syndrome

MalaCards integrated aliases for Severe Acute Respiratory Syndrome:

Name: Severe Acute Respiratory Syndrome 12 76 53 3 44 15 73
Sars 12 53 3
Sars-Cov Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2945
ICD10 33 J12.81 U04
ICD9CM 35 079.82
MeSH 44 D045169
NCIt 50 C85064
SNOMED-CT 68 398447004
UMLS 73 C1175175

Summaries for Severe Acute Respiratory Syndrome

Disease Ontology : 12 A viral infectious disease that results in infection located in respiratory tract, has material basis in SARS coronavirus (SARS-CoV), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. The infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards based summary : Severe Acute Respiratory Syndrome, also known as sars, is related to sarcoidosis 1 and avian influenza, and has symptoms including fever, headache and body aches. An important gene associated with Severe Acute Respiratory Syndrome is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Lopinavir and Ritonavir have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and testes, and related phenotype is immune system.

CDC : 3 This website is archived for historical purposes and is no longer being maintained or updated.

Wikipedia : 76 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Related Diseases for Severe Acute Respiratory Syndrome

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Severe Acute Respiratory Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 31.2 CCL2 CCL5 CXCL10 IFNG TNF
2 avian influenza 30.4 CXCL10 CXCL8 TNF
3 west nile virus 29.8 CD209 CLEC4M IFNA1 IRF3
4 gastroenteritis 29.3 CXCL8 IFNA1 IFNG TNF
5 influenza 29.2 CCL5 IFNA1 IFNB1 IFNG IRF3 TMPRSS2
6 encephalitis 29.1 CCL2 CCL5 CD209 CLEC4M CXCL10 IRF3
7 hemorrhagic fever 28.6 CD209 CD40LG IFNG TNF
8 pneumonia 28.6 CCL2 CCL5 CD40LG CXCL8 TNF
9 hepatitis c 27.0 CLEC4M CXCL10 IFNA1 IFNB1 IFNG IRF3
10 neurodevelopmental disorder with microcephaly, ataxia, and seizures 11.3
11 sarcosinemia 11.3
12 epidemic typhus 11.1
13 microcephaly 11.0
14 arteriovenous malformations of the brain 10.9
15 autosomal recessive non-syndromic intellectual disability 10.9
16 oral erosive lichen 10.8 IFNA1 IFNB1
17 herpes simplex virus keratitis 10.7 CCL2 CXCL8
18 scorpion envenomation 10.6 CCL5 TNF
19 israeli tick typhus 10.6 CCL2 CXCL8
20 respiratory syncytial virus infectious disease 10.5 CCL5 IFNB1
21 staphylococcal toxic shock syndrome 10.5 IFNG TNF
22 engraftment syndrome 10.5 CXCL8 IFNA1
23 primary peritoneal carcinoma 10.5 CXCL10 CXCL8 IFNG
24 autoimmune myocarditis 10.5 IFNG TNF
25 invasive aspergillosis 10.5 CXCL10 CXCL8 IFNG
26 extrinsic allergic alveolitis 10.5 CCL2 CCL5 CXCL8
27 stromal keratitis 10.5 CCL2 CXCL10 TNF
28 stachybotrys chartarum 10.4 CCL2 CCL5 TNF
29 common wart 10.4 CD209 CXCL8
30 idiopathic interstitial pneumonia 10.4 CCL2 CXCL8 IFNG
31 newcastle disease 10.4 IFNA1 IFNB1 IRF3
32 paracoccidioidomycosis 10.4 CXCL10 IFNG TNF
33 tungiasis 10.4 CXCL8 TNF
34 neurosyphilis 10.4 CXCL10 CXCL8
35 acute respiratory coronavirus infection 10.4
36 orofacial granulomatosis 10.4 CCL5 IFNG TNF
37 marburg hemorrhagic fever 10.3 CD209 IFNB1 TNF
38 trichosporonosis 10.3 IFNG TNF
39 null-cell leukemia 10.3 IFNA1 TNF
40 streptococcal toxic-shock syndrome 10.3 CXCL8 TNF
41 alopecia areata 10.3 CXCL10 IFNG TNF
42 filariasis 10.3 CCL5 IFNG TNF
43 allergic asthma 10.3 CCL5 CXCL8 IFNG
44 tuberculous meningitis 10.3 CCL2 CXCL8 TNF
45 pyelonephritis 10.3 CCL2 CXCL8 TNF
46 polyradiculoneuropathy 10.3 CCL5 IFNG STAT1
47 silicosis 10.3 CCL2 CXCL8 TNF
48 chorioamnionitis 10.2 CCL2 CXCL8 TNF
49 crohn's colitis 10.2 CXCL8 IFNG TNF
50 meconium aspiration syndrome 10.2 CXCL8 IFNG TNF

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to Severe Acute Respiratory Syndrome

Symptoms & Phenotypes for Severe Acute Respiratory Syndrome

Symptoms:

12
  • fever
  • headache
  • body aches
  • dry cough
  • hypoxia

UMLS symptoms related to Severe Acute Respiratory Syndrome:


coughing, fever, pruritus, snoring

MGI Mouse Phenotypes related to Severe Acute Respiratory Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 IFNG IRF3 STAT1 TMPRSS2 TNF ACE2

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

Drugs for Severe Acute Respiratory Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lopinavir Approved Phase 2, Phase 3,Not Applicable 192725-17-0 92727
2
Ritonavir Approved, Investigational Phase 2, Phase 3,Not Applicable 155213-67-5 392622
3
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
4
Interferon beta-1b Approved Phase 2, Phase 3 145155-23-3
5 tannic acid Approved, Nutraceutical Phase 2, Phase 3
6 Anti-HIV Agents Phase 2, Phase 3,Not Applicable
7 Anti-Infective Agents Phase 2, Phase 3,Not Applicable
8 Anti-Retroviral Agents Phase 2, Phase 3,Not Applicable
9 Antiviral Agents Phase 2, Phase 3,Not Applicable
10 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Not Applicable
11 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Not Applicable
12 HIV Protease Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
13
protease inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
14 interferons Phase 2, Phase 3
15 Adjuvants, Immunologic Phase 2, Phase 3,Phase 1
16 Interferon-beta Phase 2, Phase 3
17 Interferon-alpha Phase 2
18
Sorbitol Approved Phase 1 50-70-4 5780
19
Glutamic Acid Approved, Nutraceutical Phase 1 56-86-0 33032
20 Vaccines Phase 1
21 Antibodies Phase 1
22 gamma-Globulins Phase 1
23 Immunoglobulins Phase 1
24 Immunoglobulins, Intravenous Phase 1
25 Myeloma Proteins Phase 1
26 Paraproteins Phase 1
27 Rho(D) Immune Globulin Phase 1
28 Antibodies, Monoclonal Phase 1
29 Somatomedin B Phase 1
30
Ribavirin Approved Not Applicable 36791-04-5 37542
31 Antimetabolites Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS Completed NCT03465085 Phase 3 Unfractionated heparin;Streptokinase
2 MERS-CoV Infection tReated With A Combination of Lopinavir /Ritonavir and Interferon Beta-1b Recruiting NCT02845843 Phase 2, Phase 3 Combination of Lopinavir /Ritonavir and Interferon beta-1b;Placebo
3 Study of Alferon® LDO (Low Dose Oral) in Normal Volunteers Completed NCT00215826 Phase 2 Alferon LDO
4 Phase I, Open Label Dose Ranging Safety Study of GLS-5300 in Healthy Volunteers Unknown status NCT02670187 Phase 1
5 Phase I Study of a Vaccine for Severe Acute Respiratory Syndrome (SARS) Completed NCT00099463 Phase 1 Vaccine;VRC-SRSDNA015-00-VP
6 Safety, Tolerability, and Pharmacokinetics of SAB-301 in Healthy Adults Completed NCT02788188 Phase 1
7 Saudi Outcomes of ECMO-treated MERS-CoV Patients Completed NCT02627378 Phase 1
8 A Safety, Tolerability, Pharmacokinetics and Immunogenicity Trial of Co-administered MERS-CoV Antibodies REGN3048 and REGN3051 Recruiting NCT03301090 Phase 1
9 Safety and Immunogenicity of a Candidate MERS-CoV Vaccine (MERS001) Recruiting NCT03399578 Phase 1
10 Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study Withdrawn NCT01376765 Phase 1 Aluminum hydroxide adjuvant (Alhydrogel®)
11 SARS Coronavirus Vaccine (SARS-CoV) Withdrawn NCT00533741 Phase 1 Aluminum hydroxide;Placebo
12 A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome Unknown status NCT00578825 Not Applicable Lopinavir / Ritonavir plus Ribavirin
13 Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children Unknown status NCT00173563
14 Investigating Severe Acute Respiratory Syndrome (SARS) Completed NCT00066209
15 Contamination During Removal of Two Different Personal Protective Systems Completed NCT00150475 Not Applicable
16 Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome Completed NCT00173459
17 Collection of Convalescent SARS Plasma by Apheresis Completed NCT00342524
18 Seroprevalence of MERS-CoV IgG in Healthcare Workers Completed NCT02497885
19 Clinical Study of SARS in Children Completed NCT00173576
20 Respiratory Virus Outpatient Study (FLU 002 Plus) Completed NCT01056354
21 Collection and Testing of Respiratory Samples Completed NCT01302418
22 Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome Recruiting NCT03443102
23 Respiratory Virus Hospitalization Study (FLU 003 Plus) Recruiting NCT01056185
24 A Clinical Cohort Study of Pneumonia in Respiratory Intensive Care Unit Recruiting NCT02738645
25 Detect Novel Pathogens and Characterize Emerging Infections Recruiting NCT01979705
26 Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases Recruiting NCT01200953
27 Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure Recruiting NCT03225807
28 The Respiratory Protection Effectiveness Clinical Trial Active, not recruiting NCT01249625 Not Applicable
29 Collection of Plasma From People Who Recovered From or Were Vaccinated to Emerging Infectious Diseases Enrolling by invitation NCT02338986
30 Evaluation and Treatment of Severe Acute Respiratory Syndrome (SARS) Withdrawn NCT00073086
31 The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes Withdrawn NCT00172263 Not Applicable
32 SARS Survivor Evaluations Withdrawn NCT00523276

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Cochrane evidence based reviews: severe acute respiratory syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

Anatomical Context for Severe Acute Respiratory Syndrome

The Foundational Model of Anatomy Ontology organs/tissues related to Severe Acute Respiratory Syndrome:

19
Respiratory Tract

MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

41
Lung, Testes, Monocytes, T Cells, Liver, Thyroid, Kidney

Publications for Severe Acute Respiratory Syndrome

Articles related to Severe Acute Respiratory Syndrome:

(show top 50) (show all 659)
# Title Authors Year
1
Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteenA year follow-up. ( 29594456 )
2018
2
Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3. ( 29294448 )
2018
3
Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis. ( 29789363 )
2018
4
Correction to: Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR. ( 29273879 )
2018
5
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-I^ antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation. ( 28591694 )
2017
6
Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). ( 28159163 )
2017
7
Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. ( 28373583 )
2017
8
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. ( 28148787 )
2017
9
No. 225-Management Guidelines for Obstetric Patients and Neonates Born to Mothers With Suspected or Probable Severe Acute Respiratory Syndrome (SARS). ( 28729104 )
2017
10
A 12-year follow-up study of combined treatment of post-severe acute respiratory syndrome patients with femoral head necrosis. ( 29089773 )
2017
11
Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies. ( 29143192 )
2017
12
Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR. ( 28220326 )
2017
13
Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus. ( 28750053 )
2017
14
Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. ( 28404843 )
2017
15
Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS). ( 27501327 )
2016
16
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. ( 27170748 )
2016
17
Middle East respiratory syndrome and severe acute respiratory syndrome. ( 26855039 )
2016
18
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). ( 26953343 )
2016
19
The contribution of the cytoplasmic retrieval signal of severe acute respiratory syndrome coronavirus to intracellular accumulation of S proteins and incorporation of S protein into virus-like particles. ( 27145752 )
2016
20
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. ( 27965448 )
2016
21
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism. ( 26861016 )
2016
22
Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats. ( 27213718 )
2016
23
Qualitative study on the shifting sociocultural meanings of the facemask in Hong Kong since the severe acute respiratory syndrome (SARS) outbreak: implications for infection control in the post-SARS era. ( 27145823 )
2016
24
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. ( 26878082 )
2016
25
Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. ( 27466418 )
2016
26
Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel. ( 26930074 )
2016
27
Modelling input-output flows of severe acute respiratory syndrome in mainland China. ( 26924026 )
2016
28
Emerging infectious diseases: Focus on infection control issues for novel coronaviruses (Severe Acute Respiratory Syndrome-CoV and Middle East Respiratory Syndrome-CoV), hemorrhagic fever viruses (Lassa and Ebola), and highly pathogenic avian influenza viruses, A(H5N1) and A(H7N9). ( 27131142 )
2016
29
Detection of the Severe Acute Respiratory Syndrome-Related Coronavirus and Alphacoronavirus in the Bat Population of Taiwan. ( 27178103 )
2016
30
Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. ( 26015500 )
2015
31
Severe acute respiratory syndrome coronaviruses with mutations in the e protein are attenuated and promising vaccine candidates. ( 25609816 )
2015
32
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome. ( 26331680 )
2015
33
Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step. ( 25552710 )
2015
34
Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism. ( 26320399 )
2015
35
New coronavirus outbreak. Lessons learned from the severe acute respiratory syndrome epidemic. ( 25591619 )
2015
36
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. ( 26719272 )
2015
37
Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor. ( 25907116 )
2015
38
Controlling Middle East Respiratory Syndrome: Lessons Learned From Severe Acute Respiratory Syndrome. ( 26240205 )
2015
39
Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques. ( 26647718 )
2015
40
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference. ( 26378163 )
2015
41
Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. ( 25348530 )
2015
42
Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology. ( 25520500 )
2015
43
ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. ( 26433221 )
2015
44
Brief Report: Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection. ( 26133021 )
2015
45
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. ( 26392224 )
2015
46
Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection. ( 25818534 )
2015
47
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins. ( 26041291 )
2015
48
Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. ( 26269185 )
2015
49
The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis. ( 25122212 )
2014
50
Severe acute respiratory syndrome: 11 years later--a radiology perspective. ( 25247939 )
2014

Variations for Severe Acute Respiratory Syndrome

Expression for Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for Severe Acute Respiratory Syndrome

Pathways related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CCL2 CCL5 CD209 CD40LG CTSL CXCL10
2
Show member pathways
13.67 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
3
Show member pathways
13.5 CCL2 CCL5 CXCL8 IFNA1 IFNB1 IFNG
4
Show member pathways
13.39 CCL2 CCL5 CD40LG CXCL10 CXCL8 STAT1
5
Show member pathways
13.25 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
6
Show member pathways
12.94 IFNA1 IFNB1 IRF3 STAT1 TNF
7
Show member pathways
12.89 CD40LG CTSL CXCL8 IFNA1 IFNG STAT1
8
Show member pathways
12.86 CCL2 CCL5 CXCL10 CXCL8 STAT1
9
Show member pathways
12.76 CCL5 CXCL10 CXCL8 IFNA1 IFNB1 IFNG
10
Show member pathways
12.71 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
11
Show member pathways
12.65 CXCL8 IFNA1 IFNB1 IFNG IRF3 STAT1
12
Show member pathways
12.56 CXCL8 IFNA1 IFNB1 IRF3 STAT1 TNF
13
Show member pathways
12.55 IFNA1 IFNB1 IFNG IRF3 STAT1
14
Show member pathways
12.49 IFNA1 IFNB1 IFNG TNF
15
Show member pathways
12.35 CCL2 CXCL10 CXCL8 IFNG TNF
16
Show member pathways
12.33 CCL2 CCL5 IFNG TNF
17
Show member pathways
12.3 IFNA1 IFNB1 IFNG STAT1
18
Show member pathways
12.27 CXCL8 IFNB1 IRF3 TNF
19
Show member pathways
12.27 CXCL8 IFNG IRF3 STAT1 TNF
20
Show member pathways
12.26 CD40LG IFNG STAT1 TNF
21
Show member pathways
12.22 CD209 CLEC4M STAT1 TNF
22
Show member pathways
12.22 IFNA1 IFNB1 IFNG STAT1 TNF
23 12.12 CD209 CLEC4M IFNA1 IFNB1 IFNG STAT1
24 12.12 CCL2 CCL5 CD40LG CXCL10 IFNA1 IFNG
25
Show member pathways
12.12 CCL2 CCL5 CD209 CLEC4M CXCL10 CXCL8
26 12.11 CCL2 CTSL IFNG TNF
27
Show member pathways
12.09 CCL2 CCL5 CXCL8 IFNG STAT1
28 12.07 CXCL8 IFNA1 IFNB1 IRF3 STAT1 TNF
29 12.06 IFNB1 IFNG STAT1 TNF
30 12.02 CCL2 CXCL10 CXCL8 IFNG TNF
31
Show member pathways
12.02 CTSL CXCL10 CXCL8 IFNB1 IFNG STAT1
32
Show member pathways
12.01 CCL2 CCL5 CXCL10 CXCL8
33 12 CCL2 CXCL8 STAT1 TNF
34 11.97 CCL2 CCL5 CXCL10 TNF
35 11.96 CD209 IFNG TNF
36 11.92 CXCL8 IFNB1 IFNG
37 11.92 CCL2 CXCL8 STAT1 TNF
38 11.91 IFNA1 IFNB1 IFNG STAT1
39 11.87 CXCL8 IFNG TNF
40 11.86 CD40LG CXCL8 TNF
41
Show member pathways
11.8 CD40LG CXCL8 IFNG TNF
42 11.8 CCL2 CCL5 CTSL CXCL8 IFNG TNF
43 11.79 CXCL8 IFNG STAT1
44 11.78 CD209 IFNB1 IFNG TNF
45 11.75 CXCL8 IRF3 TNF
46 11.7 CCL2 CCL5 CXCL8 TNF
47
Show member pathways
11.69 CD40LG CXCL8 IFNG TNF
48 11.63 IFNG STAT1 TNF
49 11.54 CCL2 IFNG TNF
50 11.54 CCL2 CCL5 CXCL10 CXCL8 TNF

GO Terms for Severe Acute Respiratory Syndrome

Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE2 CCL2 CCL5 CD40LG CTRL CTSL
2 extracellular region GO:0005576 9.47 ACE2 CCL2 CCL5 CD209 CD40LG CLEC4M
3 external side of plasma membrane GO:0009897 9.46 CD209 CD40LG CXCL10 TNF

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.99 ACE2 CXCL10 CXCL8 TNF
2 chemotaxis GO:0006935 9.95 CCL2 CCL5 CXCL10 CXCL8
3 adaptive immune response GO:0002250 9.91 CD209 CLEC4M CTSL IFNA1 IFNB1 IFNG
4 defense response GO:0006952 9.89 CXCL10 CXCL8 IFNA1 IFNB1 TNF
5 cellular response to interferon-gamma GO:0071346 9.88 CCL2 CCL5 STAT1
6 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 CXCL10 CXCL8 IRF3 TNF
7 viral entry into host cell GO:0046718 9.87 ACE2 CD209 CLEC4M
8 cellular response to interleukin-1 GO:0071347 9.87 CCL2 CCL5 CXCL8
9 cell chemotaxis GO:0060326 9.86 CCL2 CCL5 CXCL10
10 B cell differentiation GO:0030183 9.86 CD40LG IFNA1 IFNB1
11 interferon-gamma-mediated signaling pathway GO:0060333 9.86 IFNG IRF3 STAT1
12 regulation of insulin secretion GO:0050796 9.85 CCL5 IFNG TNF
13 neutrophil chemotaxis GO:0030593 9.85 CCL2 CCL5 CXCL8
14 positive regulation of T cell proliferation GO:0042102 9.85 CCL5 CD209 CD40LG
15 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 CCL5 STAT1 TNF
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 CCL5 STAT1 TNF
17 chemokine-mediated signaling pathway GO:0070098 9.84 CCL2 CCL5 CXCL10 CXCL8
18 protein kinase B signaling GO:0043491 9.82 CCL2 CCL5 TNF
19 antigen processing and presentation GO:0019882 9.81 CD209 CLEC4M CTSL
20 negative regulation of viral genome replication GO:0045071 9.81 CCL5 IFNB1 TNF
21 type I interferon signaling pathway GO:0060337 9.81 IFNA1 IFNB1 IRF3 STAT1
22 response to virus GO:0009615 9.8 CCL5 CXCL10 IFNB1 IFNG TNF
23 response to exogenous dsRNA GO:0043330 9.79 IFNA1 IFNB1 IRF3
24 B cell proliferation GO:0042100 9.78 CD40LG IFNA1 IFNB1
25 cellular response to fibroblast growth factor stimulus GO:0044344 9.77 CCL2 CCL5 CXCL8
26 regulation of type I interferon-mediated signaling pathway GO:0060338 9.77 IFNA1 IFNB1 STAT1
27 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.74 IFNA1 IFNB1 IFNG
28 defense response to virus GO:0051607 9.73 CXCL10 IFNA1 IFNB1 IFNG IRF3 STAT1
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG TNF
30 positive regulation of T cell migration GO:2000406 9.72 CCL5 CXCL10
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 CCL2 STAT1
32 cellular response to interferon-beta GO:0035458 9.72 IFNB1 STAT1
33 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
34 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG STAT1
35 positive regulation of interferon-alpha production GO:0032727 9.71 IRF3 STAT1
36 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.7 CCL5 CXCL8
37 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
38 neutrophil activation GO:0042119 9.7 CCL5 CXCL8
39 viral genome replication GO:0019079 9.7 CCL2 CD209 CLEC4M
40 modulation by virus of host morphology or physiology GO:0019048 9.67 CD209 CLEC4M
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 CCL5 IRF3 TNF
42 cell-cell recognition GO:0009988 9.66 CD209 CLEC4M
43 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
44 virion attachment to host cell GO:0019062 9.64 CD209 CLEC4M
45 receptor biosynthetic process GO:0032800 9.63 ACE2 TNF
46 peptide antigen transport GO:0046968 9.62 CD209 CLEC4M
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IFNG TNF
48 leukocyte cell-cell adhesion GO:0007159 9.62 CCL5 CD209 CD40LG CLEC4M
49 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 IFNG TNF
50 macrophage apoptotic process GO:0071888 9.58 CTSL IRF3

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.54 ACE2 CD209 CLEC4M
2 type I interferon receptor binding GO:0005132 9.43 IFNA1 IFNB1
3 CXCR chemokine receptor binding GO:0045236 9.4 CXCL10 CXCL8
4 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG STAT1 TNF
5 virion binding GO:0046790 9.32 CD209 CLEC4M
6 cytokine activity GO:0005125 9.28 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
7 CCR5 chemokine receptor binding GO:0031730 9.26 CCL5 STAT1
8 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8

Sources for Severe Acute Respiratory Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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