ADASCID
MCID: SVR095
MIFTS: 41

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency (ADASCID)

Categories: Blood diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Severe Combined Immunodeficiency, Autosomal Recessive, T...

MalaCards integrated aliases for Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

Name: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency 57 6
Severe Combined Immunodeficiency Due to Ada Deficiency 57 75 29 6 40
Partial Adenosine Deaminase Deficiency 29 6 73
Severe Combined Immunodeficiency Due to Adenosine Deaminase Deficiency 59 73
Adenosine Deaminase Deficiency, Partial 57 13
Adenosine Deaminase Deficiency 75 73
Scid Due to Ada Deficiency 57 75
Ada Deficiency 59 75
Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/b-Cell-Negative/nk-Cell-Negative Due to Adenosine Deaminase Deficiency 75
Severe Combined Immunodeficiency Autosomal Recessive T-Cell Negative/b-Cell Negative/nk-Cell Negative Due to Adenosine Deaminase Deficiency 75
Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/b Cell-Negative/nk Cell-Negative Due to Adenosine Deaminase Deficiency 75
Scid Due to Adenosine Deaminase Deficiency 59
Scid Due to Ada Deficiency, Early-Onset 57
Ada-Scid 57
Adascid 75

Characteristics:

Orphanet epidemiological data:

59
severe combined immunodeficiency due to adenosine deaminase deficiency
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000 (Europe); Age of onset: Infancy,Neonatal; Age of death: early childhood;

OMIM:

57
Inheritance:
autosomal recessive
somatic mosaicism

Miscellaneous:
late onset combined immunodeficiency with allelic variant
85-90% with manifestations in first months of life
10-15% with primarily defects of cellular immunity, not manifesting until >2yrs of age
recurrent bacterial, viral, and fungal infections
treatment with polyethylene glycol-modified bovine ada, bone marrow transplantation, and/or gene therapy


HPO:

32
severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency:
Inheritance somatic mosaicism autosomal recessive inheritance


Classifications:



Summaries for Severe Combined Immunodeficiency, Autosomal Recessive, T...

UniProtKB/Swiss-Prot : 75 Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency: An autosomal recessive disorder accounting for about 50% of non-X- linked SCIDs. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell- mediated cellular immunity due to a defect in T-cell development. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity who have partial ADA deficiency.

MalaCards based summary : Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency, also known as severe combined immunodeficiency due to ada deficiency, is related to adenosine deaminase deficiency and severe combined immunodeficiency, x-linked. An important gene associated with Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency is ADA (Adenosine Deaminase). Affiliated tissues include t cells, b cells and nk cells, and related phenotypes are failure to thrive and sinusitis

Description from OMIM: 102700

Related Diseases for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Diseases related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 adenosine deaminase deficiency 12.2
2 severe combined immunodeficiency, x-linked 11.4
3 severe combined immunodeficiency 10.4
4 combined t cell and b cell immunodeficiency 10.4
5 purine nucleoside phosphorylase deficiency 10.2
6 lymphoma 10.2
7 hematopoietic stem cell transplantation 10.1
8 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.1
9 omenn syndrome 10.1
10 dermatofibrosarcoma protuberans 10.1
11 neutropenia 10.1
12 pulmonary alveolar proteinosis 10.1
13 lung disease 10.1
14 osteoporosis 9.9
15 myelofibrosis 9.9
16 muscular dystrophy, duchenne type 9.9
17 dermatitis, atopic 9.9
18 hemoglobin h disease 9.9
19 chronic granulomatous disease 9.9
20 common variable immunodeficiency 9.9
21 diabetes mellitus 9.9
22 hepatitis 9.9
23 liver disease 9.9
24 t cell deficiency 9.9
25 hemosiderosis 9.9
26 hypothyroidism 9.9
27 dermatitis 9.9
28 primary hyperoxaluria 9.9
29 food allergy 9.9
30 pneumonia 9.9
31 cerebral lymphoma 9.9
32 acute disseminated encephalomyelitis 9.9
33 thyroiditis 9.9
34 muscular dystrophy 9.9
35 plasmablastic lymphoma 9.9
36 pancytopenia 9.9
37 mosaic trisomy 8 9.9

Graphical network of the top 20 diseases related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:



Diseases related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency

Symptoms & Phenotypes for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Symptoms via clinical synopsis from OMIM:

57
Growth Other:
failure to thrive

Abdomen Liver:
hepatomegaly

Skeletal Spine:
platyspondyly

Respiratory Airways:
asthma

Respiratory Lung:
pneumonia

Neoplasia:
b-cell lymphoma

Genitourinary Kidneys:
mesangial sclerosis

Skeletal Limbs:
thick growth arrest lines

Abdomen Spleen:
splenomegaly

Respiratory Nasopharynx:
sinusitis

Immunology:
lymphopenia
frequent fungal, viral, and opportunistic infections
absent b cells
absent t cells
absent or reduced cd3+ cells
more
Abdomen Gastrointestinal:
diarrhea

Hematology:
eosinophilia
autoimmune hemolytic anemia
idiopathic thrombocytopenia

Chest External Features:
cupping and flaring of costochondral junctions

Skeletal Pelvis:
pelvic dysplasia

Laboratory Abnormalities:
reduced erythrocyte adenosine deaminase activity
increased ige levels
low or absent iga levels
low or absent igm levels
absent igg2 subclass
more

Clinical features from OMIM:

102700

Human phenotypes related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

59 32 (show all 44)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 failure to thrive 59 32 frequent (33%) Frequent (79-30%) HP:0001508
2 sinusitis 59 32 frequent (33%) Frequent (79-30%) HP:0000246
3 recurrent upper respiratory tract infections 59 32 frequent (33%) Frequent (79-30%) HP:0002788
4 recurrent otitis media 59 32 frequent (33%) Frequent (79-30%) HP:0000403
5 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
6 recurrent pneumonia 59 32 frequent (33%) Frequent (79-30%) HP:0006532
7 decrease in t cell count 59 32 frequent (33%) Frequent (79-30%) HP:0005403
8 b lymphocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0010976
9 increased ige level 59 32 frequent (33%) Frequent (79-30%) HP:0003212
10 inflammatory abnormality of the skin 59 32 frequent (33%) Frequent (79-30%) HP:0011123
11 allergy 59 32 frequent (33%) Frequent (79-30%) HP:0012393
12 pulmonary insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0010444
13 absence of lymph node germinal center 59 32 frequent (33%) Frequent (79-30%) HP:0002849
14 recurrent opportunistic infections 59 32 frequent (33%) Frequent (79-30%) HP:0005390
15 anti-thyroid peroxidase antibody positivity 59 32 frequent (33%) Frequent (79-30%) HP:0025379
16 absent tonsils 59 32 frequent (33%) Frequent (79-30%) HP:0030813
17 splenomegaly 32 HP:0001744
18 hepatomegaly 32 HP:0002240
19 platyspondyly 32 HP:0000926
20 autoimmunity 59 Frequent (79-30%)
21 lymphopenia 59 Frequent (79-30%)
22 asthma 32 HP:0002099
23 abnormality of pelvic girdle bone morphology 32 HP:0002644
24 recurrent bacterial infections 32 HP:0002718
25 recurrent viral infections 32 HP:0004429
26 pneumonia 32 HP:0002090
27 recurrent fungal infections 32 HP:0002841
28 iga deficiency 32 HP:0002720
29 eosinophilia 32 HP:0001880
30 igm deficiency 32 HP:0002850
31 autoimmune hemolytic anemia 32 HP:0001890
32 autoimmune thrombocytopenia 32 HP:0001973
33 severe combined immunodeficiency 32 HP:0004430
34 immunoglobulin igg2 deficiency 32 HP:0008348
35 anterior rib cupping 32 HP:0000907
36 aplasia of the thymus 32 HP:0005359
37 b-cell lymphoma 32 HP:0012191
38 severe b lymphocytopenia 32 HP:0005365
39 absent cellular immunity 59 Frequent (79-30%)
40 abnormality of humoral immunity 59 Frequent (79-30%)
41 absent specific antibody response 32 HP:0005424
42 diffuse mesangial sclerosis 32 HP:0001967
43 reduced red cell adenosine deaminase activity 32 HP:0030273
44 lack of t cell function 32 frequent (33%) HP:0005354

Drugs & Therapeutics for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Search Clinical Trials , NIH Clinical Center for Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency

Genetic Tests for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Genetic tests related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

# Genetic test Affiliating Genes
1 Severe Combined Immunodeficiency Due to Ada Deficiency 29 ADA
2 Partial Adenosine Deaminase Deficiency 29

Anatomical Context for Severe Combined Immunodeficiency, Autosomal Recessive, T...

MalaCards organs/tissues related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

41
T Cells, B Cells, Nk Cells, Bone, Thymus, Bone Marrow, Thyroid

Publications for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Articles related to Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

# Title Authors Year
1
Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency. ( 19665771 )
2009
2
Partial adenosine deaminase deficiency: another family from southern Africa. ( 3781559 )
1986
3
Genetic expression in partial adenosine deaminase deficiency. mRNA levels and protein turnover for the enzyme variants in human B-lymphoblast cell lines. ( 3871777 )
1985
4
Complete and partial adenosine deaminase deficiency. Relationship of immune function to metabolite concentrations, enzyme activity, and effects of therapy. ( 3907453 )
1985
5
Genetic heterogeneity in partial adenosine deaminase deficiency. ( 6863546 )
1983

Variations for Severe Combined Immunodeficiency, Autosomal Recessive, T...

UniProtKB/Swiss-Prot genetic disease variations for Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

75 (show all 27)
# Symbol AA change Variation ID SNP ID
1 ADA p.His15Asp VAR_002210 rs121908725
2 ADA p.Gly20Arg VAR_002211 rs121908724
3 ADA p.Gly74Cys VAR_002212 rs121908730
4 ADA p.Arg76Trp VAR_002213 rs121908736
5 ADA p.Ala83Asp VAR_002215 rs121908726
6 ADA p.Arg101Leu VAR_002216 rs121908714
7 ADA p.Arg101Trp VAR_002217 rs121908717
8 ADA p.Arg101Gln VAR_002218 rs121908714
9 ADA p.Leu107Pro VAR_002219 rs121908739
10 ADA p.Val129Met VAR_002220 rs121908731
11 ADA p.Gly140Glu VAR_002221 rs121908732
12 ADA p.Arg149Gln VAR_002223 rs121908737
13 ADA p.Arg149Trp VAR_002224 rs121908733
14 ADA p.Arg156Cys VAR_002226 rs121908735
15 ADA p.Arg156His VAR_002227 rs121908722
16 ADA p.Val177Met VAR_002228 rs121908719
17 ADA p.Ala179Asp VAR_002229 rs121908727
18 ADA p.Gln199Pro VAR_002230 rs121908734
19 ADA p.Arg211Cys VAR_002231 rs121908740
20 ADA p.Arg211His VAR_002232 rs121908716
21 ADA p.Ala215Thr VAR_002233 rs114025668
22 ADA p.Gly216Arg VAR_002234 rs121908723
23 ADA p.Pro274Leu VAR_002236 rs121908738
24 ADA p.Ser291Leu VAR_002237 rs121908721
25 ADA p.Pro297Gln VAR_002238 rs121908718
26 ADA p.Leu304Arg VAR_002239 rs199422327
27 ADA p.Ala329Val VAR_002240 rs121908715

ClinVar genetic disease variations for Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency:

6 (show top 50) (show all 201)
# Gene Variation Type Significance SNP ID Assembly Location
1 ADA NM_000022.3(ADA): c.260T> C (p.Val87Ala) single nucleotide variant Uncertain significance rs778994749 GRCh38 Chromosome 20, 44626558: 44626558
2 ADA NM_000022.3(ADA): c.260T> C (p.Val87Ala) single nucleotide variant Uncertain significance rs778994749 GRCh37 Chromosome 20, 43255199: 43255199
3 ADA NM_000022.3(ADA): c.311C> T (p.Pro104Leu) single nucleotide variant Likely pathogenic GRCh37 Chromosome 20, 43255148: 43255148
4 ADA NM_000022.3(ADA): c.311C> T (p.Pro104Leu) single nucleotide variant Likely pathogenic GRCh38 Chromosome 20, 44626507: 44626507
5 ADA NM_000022.3(ADA): c.61T> G (p.Ser21Ala) single nucleotide variant Uncertain significance rs139350872 GRCh37 Chromosome 20, 43264902: 43264902
6 ADA NM_000022.3(ADA): c.61T> G (p.Ser21Ala) single nucleotide variant Uncertain significance rs139350872 GRCh38 Chromosome 20, 44636261: 44636261
7 ADA NC_000020.11: g.(?_44651555)_(44651627_?)del deletion Pathogenic GRCh38 Chromosome 20, 44651555: 44651627
8 ADA NC_000020.11: g.(?_44651555)_(44651627_?)del deletion Pathogenic GRCh37 Chromosome 20, 43280196: 43280268
9 ADA NM_000022.3(ADA): c.218+2dup duplication Uncertain significance GRCh38 Chromosome 20, 44629045: 44629045
10 ADA NM_000022.3(ADA): c.218+2dup duplication Uncertain significance GRCh37 Chromosome 20, 43257685: 43257685
11 ADA NM_000022.3(ADA): c.219-1G> A single nucleotide variant Likely pathogenic rs751147673 GRCh38 Chromosome 20, 44626600: 44626600
12 ADA NM_000022.3(ADA): c.219-1G> A single nucleotide variant Likely pathogenic rs751147673 GRCh37 Chromosome 20, 43255241: 43255241
13 ADA NM_000022.3(ADA): c.350G> A (p.Trp117Ter) single nucleotide variant Likely pathogenic rs749484894 GRCh38 Chromosome 20, 44626468: 44626468
14 ADA NM_000022.3(ADA): c.350G> A (p.Trp117Ter) single nucleotide variant Likely pathogenic rs749484894 GRCh37 Chromosome 20, 43255109: 43255109
15 ADA NM_000022.3(ADA): c.396dup (p.Val133Serfs) duplication Likely pathogenic GRCh38 Chromosome 20, 44625651: 44625651
16 ADA NM_000022.3(ADA): c.396dup (p.Val133Serfs) duplication Likely pathogenic GRCh37 Chromosome 20, 43254291: 43254291
17 ADA NM_000022.3(ADA): c.383_404dup (p.Leu137Glyfs) duplication Likely pathogenic GRCh38 Chromosome 20, 44625643: 44625664
18 ADA NM_000022.3(ADA): c.383_404dup (p.Leu137Glyfs) duplication Likely pathogenic GRCh37 Chromosome 20, 43254283: 43254283
19 ADA NM_000022.3(ADA): c.478+6T> A single nucleotide variant Uncertain significance GRCh38 Chromosome 20, 44625563: 44625563
20 ADA NM_000022.3(ADA): c.478+6T> A single nucleotide variant Uncertain significance GRCh37 Chromosome 20, 43254204: 43254204
21 ADA NM_000022.3(ADA): c.603C> G (p.Tyr201Ter) single nucleotide variant Likely pathogenic GRCh38 Chromosome 20, 44624205: 44624205
22 ADA NM_000022.3(ADA): c.603C> G (p.Tyr201Ter) single nucleotide variant Likely pathogenic GRCh37 Chromosome 20, 43252846: 43252846
23 ADA NM_000022.3(ADA): c.781-4_781-3ins8 insertion Uncertain significance GRCh38 Chromosome 20, 44622655: 44622656
24 ADA NM_000022.3(ADA): c.781-4_781-3ins8 insertion Uncertain significance GRCh37 Chromosome 20, 43251296: 43251296
25 ADA NG_007385.1: g.34088_34089ins5 insertion Likely pathogenic GRCh38 Chromosome 20, 44622647: 44622648
26 ADA NG_007385.1: g.34088_34089ins5 insertion Likely pathogenic GRCh37 Chromosome 20, 43251288: 43251288
27 ADA NM_000022.3(ADA): c.790del (p.Trp264Glyfs) deletion Likely pathogenic GRCh38 Chromosome 20, 44622643: 44622643
28 ADA NM_000022.3(ADA): c.790del (p.Trp264Glyfs) deletion Likely pathogenic GRCh37 Chromosome 20, 43251283: 43251284
29 ADA NM_000022.3(ADA): c.1091del (p.Ter364=) deletion Uncertain significance GRCh38 Chromosome 20, 44619835: 44619835
30 ADA NM_000022.3(ADA): c.1091del (p.Ter364=) deletion Uncertain significance GRCh37 Chromosome 20, 43248475: 43248476
31 ADA NM_000022.3(ADA): c.467G> T (p.Arg156Leu) single nucleotide variant Uncertain significance rs121908722 GRCh38 Chromosome 20, 44625580: 44625580
32 ADA NM_000022.3(ADA): c.467G> T (p.Arg156Leu) single nucleotide variant Uncertain significance rs121908722 GRCh37 Chromosome 20, 43254221: 43254221
33 ADA NM_000022.3(ADA): c.110C> T (p.Ala37Val) single nucleotide variant Likely benign rs151336936 GRCh38 Chromosome 20, 44629155: 44629155
34 ADA NM_000022.3(ADA): c.110C> T (p.Ala37Val) single nucleotide variant Likely benign rs151336936 GRCh37 Chromosome 20, 43257796: 43257796
35 ADA NM_000022.3(ADA): c.532delG (p.Val178Terfs) deletion Likely pathogenic GRCh37 Chromosome 20, 43252917: 43252917
36 ADA NM_000022.3(ADA): c.532delG (p.Val178Terfs) deletion Likely pathogenic GRCh38 Chromosome 20, 44624276: 44624276
37 JAK3 NM_000215.3(JAK3): c.2683_2704del22 (p.Arg895Trpfs) deletion Likely pathogenic GRCh37 Chromosome 19, 17942584: 17942605
38 JAK3 NM_000215.3(JAK3): c.2683_2704del22 (p.Arg895Trpfs) deletion Likely pathogenic GRCh38 Chromosome 19, 17831775: 17831796
39 ADA NM_000022.3(ADA): c.95+9A> G single nucleotide variant Benign/Likely benign rs765216 GRCh37 Chromosome 20, 43264859: 43264859
40 ADA NM_000022.3(ADA): c.95+9A> G single nucleotide variant Benign/Likely benign rs765216 GRCh38 Chromosome 20, 44636218: 44636218
41 ADA NM_000022.3(ADA): c.703C> T (p.Arg235Trp) single nucleotide variant Pathogenic/Likely pathogenic rs778809577 GRCh38 Chromosome 20, 44622906: 44622906
42 ADA NM_000022.3(ADA): c.703C> T (p.Arg235Trp) single nucleotide variant Pathogenic/Likely pathogenic rs778809577 GRCh37 Chromosome 20, 43251547: 43251547
43 ADA NM_000022.3(ADA): c.606+10G> A single nucleotide variant Conflicting interpretations of pathogenicity rs201045221 GRCh38 Chromosome 20, 44624192: 44624192
44 ADA NM_000022.3(ADA): c.606+10G> A single nucleotide variant Conflicting interpretations of pathogenicity rs201045221 GRCh37 Chromosome 20, 43252833: 43252833
45 ADA NM_000022.3(ADA): c.7C> T (p.Gln3Ter) single nucleotide variant Pathogenic rs1057520217 GRCh38 Chromosome 20, 44651601: 44651601
46 ADA NM_000022.3(ADA): c.7C> T (p.Gln3Ter) single nucleotide variant Pathogenic rs1057520217 GRCh37 Chromosome 20, 43280242: 43280242
47 ADA NM_000022.3(ADA): c.162G> A (p.Lys54=) single nucleotide variant Conflicting interpretations of pathogenicity rs45557242 GRCh37 Chromosome 20, 43257744: 43257744
48 ADA NM_000022.3(ADA): c.162G> A (p.Lys54=) single nucleotide variant Conflicting interpretations of pathogenicity rs45557242 GRCh38 Chromosome 20, 44629103: 44629103
49 ADA NM_000022.3(ADA): c.591T> A (p.His197Gln) single nucleotide variant Uncertain significance rs142456343 GRCh37 Chromosome 20, 43252858: 43252858
50 ADA NM_000022.3(ADA): c.591T> A (p.His197Gln) single nucleotide variant Uncertain significance rs142456343 GRCh38 Chromosome 20, 44624217: 44624217

Expression for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Search GEO for disease gene expression data for Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency.

Pathways for Severe Combined Immunodeficiency, Autosomal Recessive, T...

GO Terms for Severe Combined Immunodeficiency, Autosomal Recessive, T...

Sources for Severe Combined Immunodeficiency, Autosomal Recessive, T...

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