MCID: SVR002
MIFTS: 34

Severe Nonproliferative Diabetic Retinopathy

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Severe Nonproliferative Diabetic Retinopathy

MalaCards integrated aliases for Severe Nonproliferative Diabetic Retinopathy:

Name: Severe Nonproliferative Diabetic Retinopathy 12 15 74
High Risk Non Proliferative Diabetic Retinopathy 12
Severe Npdr 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8946
ICD9CM 36 362.06
UMLS 74 C0730278

Summaries for Severe Nonproliferative Diabetic Retinopathy

MalaCards based summary : Severe Nonproliferative Diabetic Retinopathy, also known as high risk non proliferative diabetic retinopathy, is related to microvascular complications of diabetes 5 and macular dystrophy, dominant cystoid. An important gene associated with Severe Nonproliferative Diabetic Retinopathy is STK38L (Serine/Threonine Kinase 38 Like), and among its related pathways/superpathways are MAPK signaling pathway and Ras signaling pathway. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and behavior/neurological

Related Diseases for Severe Nonproliferative Diabetic Retinopathy

Graphical network of the top 20 diseases related to Severe Nonproliferative Diabetic Retinopathy:



Diseases related to Severe Nonproliferative Diabetic Retinopathy

Symptoms & Phenotypes for Severe Nonproliferative Diabetic Retinopathy

GenomeRNAi Phenotypes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.8 PRKCB STK38L VEGFA

MGI Mouse Phenotypes related to Severe Nonproliferative Diabetic Retinopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 INS OPN4 PRKCB SEMA3E VEGFA
2 nervous system MP:0003631 9.43 INS OPN4 PRKCB SEMA3E STK38L VEGFA
3 vision/eye MP:0005391 8.92 INS OPN4 SEMA3E VEGFA

Drugs & Therapeutics for Severe Nonproliferative Diabetic Retinopathy

Drugs for Severe Nonproliferative Diabetic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3
3 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3
4 Antineoplastic Agents, Immunological Phase 4,Phase 2,Phase 3
5
Ranibizumab Approved Phase 3 347396-82-1 459903
6
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
7
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
8
Zinc oxide Approved Phase 3 1314-13-2
9
Zinc Approved, Investigational Phase 3 7440-66-6 32051
10
Magnesium oxide Approved Phase 3 1309-48-4 14792
11
Copper Approved, Investigational Phase 3 7440-50-8 27099
12
Octreotide Approved, Investigational Phase 3 83150-76-9 6400441 383414
13
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
14
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
15
Lutein Approved, Investigational, Nutraceutical Phase 3 127-40-2 6433159
16 Tocotrienol Investigational Phase 3 6829-55-6
17 Triamcinolone hexacetonide Phase 3
18 Anti-Inflammatory Agents Phase 3
19 Hormones Phase 3
20 Immunosuppressive Agents Phase 3
21 Hormone Antagonists Phase 3
22 Immunologic Factors Phase 3
23 Triamcinolone diacetate Phase 3
24 triamcinolone acetonide Phase 3
25 glucocorticoids Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27 Protective Agents Phase 3
28 Copper Sulfate Phase 3
29 Tocotrienols Phase 3
30 Vitamins Phase 3
31 Tocopherols Phase 3
32 Antioxidants Phase 3
33 Endothelial Growth Factors Phase 3
34 Mitogens Phase 3
35 Gastrointestinal Agents Phase 3
36 Antineoplastic Agents, Hormonal Phase 3
37
Fibrinolysin Investigational Phase 2 9004-09-5
38 Fibrinolytic Agents Phase 2
39 Trientine Not Applicable
40 Chelating Agents Not Applicable
41 Insulin, Globin Zinc Not Applicable
42 insulin Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Avastin for Post-Photocoagulation Macular Edema Completed NCT00801866 Phase 4 Bevacizumab
2 Panretinal Photocoagulation for Diabetic Retinopathy With PASCAL Laser Unknown status NCT01304225 Phase 3
3 Intravitreal Bevacizumab for Diabetic Retinopathy Completed NCT00600262 Phase 2, Phase 3 intravitreal bevacizumab
4 Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema Completed NCT00444600 Phase 3 Triamcinolone Acetonide + laser;Ranibizumab + laser;Sham injection + laser;Ranibizumab + deferred laser
5 Combined Antioxidant Therapy on Oxidative Stress, Mitochondrial Dysfunction Markers in Diabetic Retinopathy Recruiting NCT03702374 Phase 3 Combined antioxidant therapy
6 Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR) Active, not recruiting NCT02718326 Phase 3 Intravitreal aflibercept injection [IAI];Sham
7 Anti-VEGF Treatment for Prevention of PDR/DME Active, not recruiting NCT02634333 Phase 3 Prompt aflibercept;Deferred aflibercept
8 Extension Study of Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy Terminated NCT00248131 Phase 3 Octreotide acetate in microspheres
9 Extension Study of the Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy Terminated NCT00248157 Phase 3 Octreotide acetate in microspheres
10 Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Completed NCT00198471 Phase 2 Vitrase
11 A Study That Tests BI 1467335 in Patients With Diabetic Eye Disease (Diabetic Retinopathy). It Looks at the Way BI 1467335 is Taken up, the Effects it Has, and How Well it is Tolerated. Recruiting NCT03238963 Phase 2 BI 1467335;Placebo
12 The TIME-2b Study: A Study of AKB-9778, a Novel Tie 2 Activator, in Patients With Non-Proliferative Diabetic Retinopathy (NPDR) Active, not recruiting NCT03197870 Phase 2 AKB-9778;Placebo
13 A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR Active, not recruiting NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
14 A Study of Keluo Xin Capsule Compare to Placebo in Terms of Efficacy and Safety in Patients With Diabetic Retinopathy Not yet recruiting NCT03258242 Phase 2 Keluo Xin capsule;Placebo oral capsule
15 Panretinal Photo-stimulation in Proliferative Diabetic Retinopathy Unknown status NCT02309502 Not Applicable
16 Early Laser Treatment for Diabetic Eye Disease in China : A Pilot Randomized Trial Unknown status NCT02956759 Not Applicable
17 Diabetic Macular Edema and Diabetic Retinopathy Screening (TeleMed) With Automated Retinal Photography Unknown status NCT01790945
18 Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics Unknown status NCT00698698
19 Observational Study of DME Following Scatter Laser Photocoagulation Completed NCT00687154 Not Applicable
20 Smartphone-based Ophthalmoscopy Completed NCT02177747 Not Applicable
21 Safety and Effectiveness Study of 532nm Laser Subthreshold Panretinal Photocoagulation for Severe NPDR Recruiting NCT01759121 Not Applicable
22 PRP vs PRP+IVC for Severe nPDR Recruiting NCT03863535 Not Applicable Conbercept
23 Simple, Mobile-based Artificial Intelligence AlgoRithms in the Detection of Diabetic ReTinopathy (SMART) Study Recruiting NCT03572699
24 Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN) Recruiting NCT03069729
25 OCT Biomarkers for Diabetic Retinopathy Recruiting NCT02330042
26 Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT Recruiting NCT03765112 Not Applicable
27 Trientine Hydrochloride for the Prevention of Macular Edema Associated With Pan-retinal Photocoagulation for Severe Non-proliferative and Proliferative Diabetic Retinopathy Terminated NCT01213888 Not Applicable Trientine Hydrochloride;Oral placebo capsules
28 Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM) Terminated NCT00718614 Not Applicable

Search NIH Clinical Center for Severe Nonproliferative Diabetic Retinopathy

Genetic Tests for Severe Nonproliferative Diabetic Retinopathy

Anatomical Context for Severe Nonproliferative Diabetic Retinopathy

MalaCards organs/tissues related to Severe Nonproliferative Diabetic Retinopathy:

42
Eye, Testes, Endothelial, Retina

Publications for Severe Nonproliferative Diabetic Retinopathy

Articles related to Severe Nonproliferative Diabetic Retinopathy:

# Title Authors Year
1
Morphometry of the normal retinal periarteral capillary-free zone and changes during severe nonproliferative diabetic retinopathy. ( 30829616 )
2019
2
Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy. ( 29626228 )
2018
3
EFFECTS OF PANRETINAL PHOTOCOAGULATION ON CHOROIDAL THICKNESS AND CHOROIDAL BLOOD FLOW IN PATIENTS WITH SEVERE NONPROLIFERATIVE DIABETIC RETINOPATHY. ( 26447396 )
2015
4
Intravitreal bevacizumab versus panretinal photocoagulation for treatment-naA^ve proliferative and severe nonproliferative diabetic retinopathy. ( 22405048 )
2012
5
The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. ( 15983221 )
2005
6
Influence of laser coagulation therapy on untreated fellow-eyes in severe nonproliferative diabetic retinopathy-spectrometric results. ( 9469548 )
1997
7
Different determinants of neovascularization on the optic disc and on the retina in patients with severe nonproliferative diabetic retinopathy. ( 7679270 )
1993

Variations for Severe Nonproliferative Diabetic Retinopathy

Expression for Severe Nonproliferative Diabetic Retinopathy

Search GEO for disease gene expression data for Severe Nonproliferative Diabetic Retinopathy.

Pathways for Severe Nonproliferative Diabetic Retinopathy

Pathways related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.25 INS PRKCB VEGFA
2
Show member pathways
12.14 INS PRKCB VEGFA
3
Show member pathways
11.52 INS PRKCB
4 11.46 PRKCB VEGFA
5 11.19 INS PRKCB
6 10.94 INS VEGFA
7 10.85 INS PRKCB
8 10.8 INS PRKCB VEGFA
9
Show member pathways
10.78 INS VEGFA
10 10.52 INS PRKCB

GO Terms for Severe Nonproliferative Diabetic Retinopathy

Biological processes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.33 INS SEMA3E VEGFA
2 sprouting angiogenesis GO:0002040 9.32 SEMA3E VEGFA
3 branching involved in blood vessel morphogenesis GO:0001569 9.26 SEMA3E VEGFA
4 positive regulation of protein autophosphorylation GO:0031954 8.96 INS VEGFA
5 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 8.62 PRKCB VEGFA

Sources for Severe Nonproliferative Diabetic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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