MCID: SVR002
MIFTS: 33

Severe Nonproliferative Diabetic Retinopathy

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Severe Nonproliferative Diabetic Retinopathy

MalaCards integrated aliases for Severe Nonproliferative Diabetic Retinopathy:

Name: Severe Nonproliferative Diabetic Retinopathy 12 15 73
High Risk Non Proliferative Diabetic Retinopathy 12
Severe Npdr 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8946
ICD9CM 35 362.06
UMLS 73 C0730278

Summaries for Severe Nonproliferative Diabetic Retinopathy

MalaCards based summary : Severe Nonproliferative Diabetic Retinopathy, also known as high risk non proliferative diabetic retinopathy, is related to microvascular complications of diabetes 5 and noma. An important gene associated with Severe Nonproliferative Diabetic Retinopathy is STK38L (Serine/Threonine Kinase 38 Like), and among its related pathways/superpathways are HIF-1 signaling pathway and Differentiation Pathway. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are nervous system and vision/eye

Related Diseases for Severe Nonproliferative Diabetic Retinopathy

Diseases related to Severe Nonproliferative Diabetic Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.5 ALB INS VEGFA
2 noma 10.1 ALB INS
3 drug allergy 10.1 ALB INS
4 microvascular complications of diabetes 3 10.1 ALB INS
5 fetal erythroblastosis 10.1 ALB INS
6 fascioliasis 10.1 ALB INS
7 autonomic nervous system disease 10.1 ALB INS
8 prediabetes syndrome 10.1 ALB INS
9 pancreas disease 10.0 ALB INS
10 autonomic neuropathy 10.0 ALB INS
11 hypoglycemic coma 10.0 INS VEGFA
12 acroosteolysis 10.0 ALB VEGFA
13 uremia 10.0 ALB INS
14 hypertensive nephropathy 10.0 ALB VEGFA
15 gastric lymphoma 10.0 ALB VEGFA
16 glucose metabolism disease 10.0 ALB INS
17 hydrops, lactic acidosis, and sideroblastic anemia 10.0 ALB VEGFA
18 rubeosis iridis 10.0 INS VEGFA
19 vein disease 10.0 ALB VEGFA
20 proteasome-associated autoinflammatory syndrome 1 10.0 ALB INS
21 hepatopulmonary syndrome 10.0 ALB VEGFA
22 intermittent claudication 10.0 ALB VEGFA
23 ovarian hyperstimulation syndrome 10.0 ALB VEGFA
24 carpal tunnel syndrome 10.0 INS VEGFA
25 severe pre-eclampsia 10.0 ALB VEGFA
26 diabetic neuropathy 10.0 INS VEGFA
27 acquired metabolic disease 10.0 ALB INS
28 brain edema 10.0 ALB VEGFA
29 peripheral vascular disease 10.0 ALB VEGFA
30 portal hypertension 10.0 ALB VEGFA
31 gonadal disease 10.0 INS VEGFA
32 autosomal genetic disease 10.0 INS VEGFA
33 intestinal disease 10.0 ALB VEGFA
34 peripheral nervous system disease 10.0 ALB INS
35 microvascular complications of diabetes 1 10.0 INS VEGFA
36 respiratory system disease 9.9 ALB VEGFA
37 gastrointestinal system cancer 9.9 ALB VEGFA
38 endocrine gland cancer 9.9 ALB VEGFA
39 hyperglycemia 9.9 ALB INS
40 background diabetic retinopathy 9.8 ALB INS VEGFA
41 retinal vascular disease 9.8 ALB INS VEGFA
42 vascular disease 9.8 ALB INS VEGFA
43 arteries, anomalies of 9.8 ALB INS VEGFA
44 urinary system disease 9.8 ALB INS VEGFA
45 gastrointestinal system disease 9.8 ALB INS VEGFA
46 nervous system disease 9.8 ALB INS VEGFA
47 large intestine cancer 9.8 ALB INS VEGFA
48 heart disease 9.8 ALB INS VEGFA
49 autosomal dominant polycystic kidney disease 9.8 ALB VEGFA
50 ewing sarcoma 9.7 ALB INS VEGFA

Graphical network of the top 20 diseases related to Severe Nonproliferative Diabetic Retinopathy:



Diseases related to Severe Nonproliferative Diabetic Retinopathy

Symptoms & Phenotypes for Severe Nonproliferative Diabetic Retinopathy

MGI Mouse Phenotypes related to Severe Nonproliferative Diabetic Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.35 INS OPN4 SEMA3E STK38L VEGFA
2 vision/eye MP:0005391 8.92 INS OPN4 SEMA3E VEGFA

Drugs & Therapeutics for Severe Nonproliferative Diabetic Retinopathy

Drugs for Severe Nonproliferative Diabetic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3
3 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3
4
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
5
Ranibizumab Approved Phase 3 347396-82-1 459903
6
Zinc Approved, Investigational Phase 3 7440-66-6
7
Copper Approved, Investigational Phase 3 7440-50-8 27099
8
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
9
Zinc oxide Approved Phase 3 1314-13-2
10
Magnesium oxide Approved Phase 3 1309-48-4 14792
11
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
12
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
13
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
14
Lutein Approved, Investigational, Nutraceutical Phase 3 127-40-2 6433159
15 Tocotrienol Investigational Phase 3 6829-55-6
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
17 Hormones Phase 3
18 glucocorticoids Phase 3
19 Immunologic Factors Phase 3
20 Anti-Inflammatory Agents Phase 3
21 Hormone Antagonists Phase 3
22 Triamcinolone hexacetonide Phase 3
23 Immunosuppressive Agents Phase 3
24 triamcinolone acetonide Phase 3
25 Triamcinolone diacetate Phase 3
26 Tocopherols Phase 3
27 Antioxidants Phase 3
28 Protective Agents Phase 3
29 Tocotrienols Phase 3
30 Copper Sulfate Phase 3
31 Vitamins Phase 3
32 Endothelial Growth Factors Phase 3
33 Mitogens Phase 3
34 Gastrointestinal Agents Phase 3
35 Antineoplastic Agents, Hormonal Phase 3
36
Fibrinolysin Investigational Phase 2 9004-09-5
37 Fibrinolytic Agents Phase 2
38 Chelating Agents Not Applicable
39 Trientine Not Applicable
40 insulin Not Applicable
41 Insulin, Globin Zinc Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Avastin for Post-Photocoagulation Macular Edema Completed NCT00801866 Phase 4 Bevacizumab
2 Panretinal Photocoagulation for Diabetic Retinopathy With PASCAL Laser Unknown status NCT01304225 Phase 3
3 Intravitreal Bevacizumab for Diabetic Retinopathy Completed NCT00600262 Phase 2, Phase 3 intravitreal bevacizumab
4 Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema Completed NCT00444600 Phase 3 Triamcinolone Acetonide + laser;Ranibizumab + laser;Sham injection + laser;Ranibizumab + deferred laser
5 Combined Antioxidant Therapy on Oxidative Stress, Mitochondrial Dysfunction Markers in Diabetic Retinopathy Recruiting NCT03702374 Phase 3 Combined antioxidant therapy
6 Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR) Active, not recruiting NCT02718326 Phase 3 Intravitreal aflibercept injection [IAI];Sham
7 Anti-VEGF Treatment for Prevention of PDR/DME Active, not recruiting NCT02634333 Phase 3 Prompt aflibercept;Deferred aflibercept
8 Extension Study of Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy Terminated NCT00248131 Phase 3 Octreotide acetate in microspheres
9 Extension Study of the Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy Terminated NCT00248157 Phase 3 Octreotide acetate in microspheres
10 Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Completed NCT00198471 Phase 2 Vitrase
11 A Study That Tests BI 1467335 in Patients With Diabetic Eye Disease (Diabetic Retinopathy). It Looks at the Way BI 1467335 is Taken up, the Effects it Has, and How Well it is Tolerated. Recruiting NCT03238963 Phase 2 BI 1467335;Placebo
12 The TIME-2b Study: A Study of AKB-9778, a Novel Tie 2 Activator, in Patients With Non-Proliferative Diabetic Retinopathy (NPDR) Active, not recruiting NCT03197870 Phase 2 AKB-9778;Placebo
13 A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR Active, not recruiting NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
14 A Study of Keluo Xin Capsule Compare to Placebo in Terms of Efficacy and Safety in Patients With Diabetic Retinopathy Not yet recruiting NCT03258242 Phase 2 Keluo Xin capsule;Placebo oral capsule
15 Panretinal Photo-stimulation in Proliferative Diabetic Retinopathy Unknown status NCT02309502 Not Applicable
16 Early Laser Treatment for Diabetic Eye Disease in China : A Pilot Randomized Trial Unknown status NCT02956759 Not Applicable
17 Diabetic Macular Edema and Diabetic Retinopathy Screening (TeleMed) With Automated Retinal Photography Unknown status NCT01790945
18 Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics Unknown status NCT00698698
19 Observational Study of DME Following Scatter Laser Photocoagulation Completed NCT00687154 Not Applicable
20 Smartphone-based Ophthalmoscopy Completed NCT02177747 Not Applicable
21 Safety and Effectiveness Study of 532nm Laser Subthreshold Panretinal Photocoagulation for Severe NPDR Recruiting NCT01759121 Not Applicable
22 Simple, Mobile-based Artificial Intelligence AlgoRithms in the Detection of Diabetic ReTinopathy (SMART) Study Recruiting NCT03572699
23 Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN) Recruiting NCT03069729
24 OCT Biomarkers for Diabetic Retinopathy Recruiting NCT02330042
25 Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT Recruiting NCT03765112 Not Applicable
26 Trientine Hydrochloride for the Prevention of Macular Edema Associated With Pan-retinal Photocoagulation for Severe Non-proliferative and Proliferative Diabetic Retinopathy Terminated NCT01213888 Not Applicable Trientine Hydrochloride;Oral placebo capsules
27 Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM) Terminated NCT00718614 Not Applicable

Search NIH Clinical Center for Severe Nonproliferative Diabetic Retinopathy

Genetic Tests for Severe Nonproliferative Diabetic Retinopathy

Anatomical Context for Severe Nonproliferative Diabetic Retinopathy

MalaCards organs/tissues related to Severe Nonproliferative Diabetic Retinopathy:

41
Eye, Retina, Brain, Kidney, Heart, Pancreas

Publications for Severe Nonproliferative Diabetic Retinopathy

Articles related to Severe Nonproliferative Diabetic Retinopathy:

# Title Authors Year
1
Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy. ( 29626228 )
2018
2
EFFECTS OF PANRETINAL PHOTOCOAGULATION ON CHOROIDAL THICKNESS AND CHOROIDAL BLOOD FLOW IN PATIENTS WITH SEVERE NONPROLIFERATIVE DIABETIC RETINOPATHY. ( 26447396 )
2015
3
Intravitreal bevacizumab versus panretinal photocoagulation for treatment-naA^ve proliferative and severe nonproliferative diabetic retinopathy. ( 22405048 )
2012
4
The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. ( 15983221 )
2005
5
Influence of laser coagulation therapy on untreated fellow-eyes in severe nonproliferative diabetic retinopathy-spectrometric results. ( 9469548 )
1997
6
Different determinants of neovascularization on the optic disc and on the retina in patients with severe nonproliferative diabetic retinopathy. ( 7679270 )
1993

Variations for Severe Nonproliferative Diabetic Retinopathy

Expression for Severe Nonproliferative Diabetic Retinopathy

Search GEO for disease gene expression data for Severe Nonproliferative Diabetic Retinopathy.

Pathways for Severe Nonproliferative Diabetic Retinopathy

Pathways related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 INS VEGFA
2 10.94 INS VEGFA
3 10.92 ALB INS VEGFA
4 10.8 ALB INS
5
Show member pathways
10.58 INS VEGFA

GO Terms for Severe Nonproliferative Diabetic Retinopathy

Cellular components related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 ALB INS SEMA3E VEGFA
2 platelet alpha granule lumen GO:0031093 8.62 ALB VEGFA

Biological processes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.32 ALB VEGFA
2 sprouting angiogenesis GO:0002040 9.26 SEMA3E VEGFA
3 branching involved in blood vessel morphogenesis GO:0001569 9.16 SEMA3E VEGFA
4 positive regulation of cell migration GO:0030335 9.13 INS SEMA3E VEGFA
5 positive regulation of protein autophosphorylation GO:0031954 8.62 INS VEGFA

Sources for Severe Nonproliferative Diabetic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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