MCID: SVR002
MIFTS: 33

Severe Nonproliferative Diabetic Retinopathy

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Severe Nonproliferative Diabetic Retinopathy

MalaCards integrated aliases for Severe Nonproliferative Diabetic Retinopathy:

Name: Severe Nonproliferative Diabetic Retinopathy 12 15 72
High Risk Non Proliferative Diabetic Retinopathy 12
Severe Npdr 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8946
ICD9CM 35 362.06
UMLS 72 C0730278

Summaries for Severe Nonproliferative Diabetic Retinopathy

MalaCards based summary : Severe Nonproliferative Diabetic Retinopathy, also known as high risk non proliferative diabetic retinopathy, is related to diabetic macular edema and microvascular complications of diabetes 5. An important gene associated with Severe Nonproliferative Diabetic Retinopathy is PRKCB (Protein Kinase C Beta), and among its related pathways/superpathways are MAPK signaling pathway and Ras signaling pathway. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and behavior/neurological

Related Diseases for Severe Nonproliferative Diabetic Retinopathy

Graphical network of the top 20 diseases related to Severe Nonproliferative Diabetic Retinopathy:



Diseases related to Severe Nonproliferative Diabetic Retinopathy

Symptoms & Phenotypes for Severe Nonproliferative Diabetic Retinopathy

GenomeRNAi Phenotypes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.8 PRKCB STK38L VEGFA

MGI Mouse Phenotypes related to Severe Nonproliferative Diabetic Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 INS OPN4 PRKCB SEMA3E VEGFA
2 nervous system MP:0003631 9.43 INS OPN4 PRKCB SEMA3E STK38L VEGFA
3 vision/eye MP:0005391 8.92 INS OPN4 SEMA3E VEGFA

Drugs & Therapeutics for Severe Nonproliferative Diabetic Retinopathy

Drugs for Severe Nonproliferative Diabetic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4 Antineoplastic Agents, Immunological Phase 4
5 Anesthetics Phase 4
6
Ranibizumab Approved Phase 3 347396-82-1 459903
7
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
8 Gastrointestinal Agents Phase 3
9 Antineoplastic Agents, Hormonal Phase 3
10
Triamcinolone Approved, Vet_approved 124-94-7 31307
11 triamcinolone acetonide
12 Triamcinolone diacetate
13 Triamcinolone hexacetonide
14 Angiogenesis Inducing Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Post-Photocoagulation Macular Edema by Intravitreal Bevacizumab. Completed NCT00801866 Phase 4 Bevacizumab
2 Effect of Adjunctive Intravitreal Bevacizumab Before Panretinal Photocoagulation in Macular Thickness and Retinal Nerve Fiber Layer Thickness Completed NCT01504724 Phase 4 bevacizumab
3 Evaluation of Ranibizumab on the Ease of Procedure and Complication Rate in Proliferative Diabetic Retinopathy (PDR) Requiring Vitrectomy Unknown status NCT00516464 Phase 3 Lucentis (ranibizumab)
4 A Phase 3, Double-Masked, Randomized Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients With Moderately Severe to Severe Nonproliferative Diabetic Retinopathy Active, not recruiting NCT02718326 Phase 3 Intravitreal aflibercept injection [IAI];Sham
5 An Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Octreotide Acetate in Microspheres in the Therapy of Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy (NPDR) or Low Risk Proliferative Diabetic Retinopathy (PDR) Terminated NCT00248157 Phase 3 Octreotide acetate in microspheres
6 An Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Octreotide Acetate in Microspheres in the Therapy of Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy (NPDR) or Low Risk Proliferative Diabetic Retinopathy (PDR) Terminated NCT00248131 Phase 3 Octreotide acetate in microspheres
7 A Randomized, Double-masked, Multicenter, Placebo Controlled Study of Keluo Xin Capsule on Efficacy and Safety in Patients With Diabetic Retinopathy Not yet recruiting NCT03258242 Phase 2 Keluo Xin capsule;Placebo oral capsule
8 Pascal Pan Retinal Photo-Stimulation in Pre-Proliferative Diabetic Retinopathy: a Safety and Efficacy Study Unknown status NCT02309502
9 Panretinal Photocoagulation (PRP) vs PRP Combined With Intravitreous Conbercept (IVC) for Severe Nonproliferative Diabetic Retinopathy (nPDR): A Randomized Clinical Trial Recruiting NCT03863535 Conbercept
10 Analysis of Angiogenic Protein and Anti-angiogenic Levels in Eyes With Diabetic Retinopathy. Recruiting NCT02026843

Search NIH Clinical Center for Severe Nonproliferative Diabetic Retinopathy

Genetic Tests for Severe Nonproliferative Diabetic Retinopathy

Anatomical Context for Severe Nonproliferative Diabetic Retinopathy

MalaCards organs/tissues related to Severe Nonproliferative Diabetic Retinopathy:

41
Eye, Endothelial, Retina, Skin

Publications for Severe Nonproliferative Diabetic Retinopathy

Articles related to Severe Nonproliferative Diabetic Retinopathy:

(show top 50) (show all 242)
# Title Authors PMID Year
1
MicroRNAs as biomarkers of diabetic retinopathy and disease progression. 38
31290435 2019
2
EVALUATION OF MULTISPECTRAL IMAGING IN DIAGNOSING DIABETIC RETINOPATHY. 38
29901495 2019
3
Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Retinopathy: Consequences of Inadvertent Treatment Interruptions. 38
30878488 2019
4
The diagnostic accuracy of an intelligent and automated fundus disease image assessment system with lesion quantitative function (SmartEye) in diabetic patients. 38
31412800 2019
5
Macular vessels density in diabetic retinopathy: quantitative assessment using optical coherence tomography angiography. 38
30194547 2019
6
Central retinal thickness following panretinal photocoagulation using a multispot semi-automated pattern-scanning laser to treat ischaemic diabetic retinopathy: Treatment in one session compared with four monthly sessions. 38
30561087 2019
7
Optical coherence tomography angiography analysis of the choriocapillary layer in treatment-naïve diabetic eyes. 38
31089870 2019
8
An Evaluation System of Fundus Photograph-Based Intelligent Diagnostic Technology for Diabetic Retinopathy and Applicability for Research. 38
31290125 2019
9
The estimated healthcare cost of diabetic retinopathy in Indonesia and its projection for 2025. 38
31285276 2019
10
Quantitative Ultra-Widefield Angiography and Diabetic Retinopathy Severity: An Assessment of Panretinal Leakage Index, Ischemic Index and Microaneurysm Count. 38
31383482 2019
11
Widefield OCT-Angiography and Fluorescein Angiography Assessments of Nonperfusion in Diabetic Retinopathy and Edema Treated with Anti-Vascular Endothelial Growth Factor. 38
31383483 2019
12
Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation. 38
31192968 2019
13
Retinal Nonperfusion Characteristics on Ultra-Widefield Angiography in Eyes With Severe Nonproliferative Diabetic Retinopathy and Proliferative Diabetic Retinopathy. 38
30973596 2019
14
Alteration of choroidal vascular structure in diabetic retinopathy. 38
31177190 2019
15
Validation of Smartphone-Based Retinal Photography for Diabetic Retinopathy Screening. 38
31100178 2019
16
Impact of Diabetic Retinopathy on Sleep, Mood, and Quality of Life. 38
31117122 2019
17
Quantitative analysis of retinal and choroid capillary ischaemia using optical coherence tomography angiography in type 2 diabetes. 38
30810284 2019
18
Macular Capillary Perfusion in Chinese Patients With Diabetic Retinopathy Obtained With Optical Coherence Tomography Angiography. 38
30998251 2019
19
Factors Associated With Visual Acuity and Central Subfield Thickness Changes When Treating Diabetic Macular Edema With Anti-Vascular Endothelial Growth Factor Therapy: An Exploratory Analysis of the Protocol T Randomized Clinical Trial. 38
30676635 2019
20
Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy. 38
31016437 2019
21
Sensitivity and Specificity of Smartphone-Based Retinal Imaging for Diabetic Retinopathy: A Comparative Study. 38
31014763 2019
22
Microaneurysm turnover is a predictor of diabetic retinopathy progression. 38
29699981 2019
23
Safety of Trypan Blue Capsule Staining to Corneal Endothelium in Patients with Diabetic Retinopathy. 38
31032113 2019
24
Morphometry of the normal retinal periarteral capillary-free zone and changes during severe nonproliferative diabetic retinopathy. 38
30829616 2019
25
Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography. 38
30550612 2018
26
Use of Telehealth Screening to Detect Diabetic Retinopathy and Other Ocular Findings in Primary Care Settings. 38
30481134 2018
27
Alteration of layer thickness in the choroid of diabetic patients. 38
29740913 2018
28
Changes in choriocapillaris and retinal morphology after laser photocoagulation by OCT angiography: A case report. 38
30431615 2018
29
Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography. 38
30326063 2018
30
Beyond vision loss: the independent impact of diabetic retinopathy on vision-related quality of life in a Chinese Singaporean population. 38
30361276 2018
31
Self-reported healthcare utilization by adults with diabetic retinopathy in the United States. 38
29958092 2018
32
Ranibizumab Induces Regression of Diabetic Retinopathy in Most Patients at High Risk of Progression to Proliferative Diabetic Retinopathy. 38
31047503 2018
33
Diet soft drink is associated with increased odds of proliferative diabetic retinopathy. 38
29360260 2018
34
Quantitative evaluation of optical coherence tomography angiography images of diabetic retinopathy eyes before and after removal of projection artifacts. 38
29660256 2018
35
A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation. 38
30237467 2018
36
Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes. 38
30108264 2018
37
[Analysis of the quality of life and the influencing factors in patients with diabetic retinopathy before and after receiving pan-retinal photocoagulation]. 38
30107655 2018
38
Progression of diabetic retinopathy severity after treatment with dexamethasone implant: a 24-month cohort study the 'DR-Pro-DEX Study'. 38
29497837 2018
39
Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy. 38
29626228 2018
40
Is there a relationship between body mass index and diabetic retinopathy in type II diabetic patients? A cross sectional study. 38
30288386 2018
41
Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography. 38
29715365 2018
42
QUANTIFICATION OF RETINAL VESSEL TORTUOSITY IN DIABETIC RETINOPATHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. 38
28333883 2018
43
Alteration of layer thickness in the choroid of diabetic patients. 38
29655280 2018
44
Distinctive Analysis of Macular Superficial Capillaries and Large Vessels Using Optical Coherence Tomographic Angiography in Healthy and Diabetic Eyes. 38
29677360 2018
45
Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy. 38
29618794 2018
46
Changes in choroidal thickness in patients with diabetic retinopathy. 38
28194551 2018
47
Skin Autofluorescence is a Noninvasive Surrogate Marker for Diabetic Microvascular Complications and Carotid Intima-Media Thickness in Japanese Patients with Type 2 Diabetes: A Cross-sectional Study. 38
29177923 2018
48
Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-A novel OCT based imaging biomarker. 38
30533048 2018
49
The Beijing Desheng Diabetic Eye Study: rationale, design, methodology and baseline data. 38
29376000 2018
50
Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients. 38
29854819 2018

Variations for Severe Nonproliferative Diabetic Retinopathy

Expression for Severe Nonproliferative Diabetic Retinopathy

Search GEO for disease gene expression data for Severe Nonproliferative Diabetic Retinopathy.

Pathways for Severe Nonproliferative Diabetic Retinopathy

Pathways related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.25 VEGFA PRKCB INS
2
Show member pathways
12.14 VEGFA PRKCB INS
3
Show member pathways
11.52 PRKCB INS
4 11.46 VEGFA PRKCB
5 11.19 PRKCB INS
6 10.94 VEGFA INS
7 10.85 PRKCB INS
8 10.84 VEGFA PRKCB INS
9
Show member pathways
10.78 VEGFA INS
10 10.52 PRKCB INS

GO Terms for Severe Nonproliferative Diabetic Retinopathy

Biological processes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.33 VEGFA SEMA3E INS
2 sprouting angiogenesis GO:0002040 9.32 VEGFA SEMA3E
3 branching involved in blood vessel morphogenesis GO:0001569 9.26 VEGFA SEMA3E
4 positive regulation of protein autophosphorylation GO:0031954 8.96 VEGFA INS
5 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 8.62 VEGFA PRKCB

Sources for Severe Nonproliferative Diabetic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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