MCID: SVR002
MIFTS: 38

Severe Nonproliferative Diabetic Retinopathy

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Severe Nonproliferative Diabetic Retinopathy

MalaCards integrated aliases for Severe Nonproliferative Diabetic Retinopathy:

Name: Severe Nonproliferative Diabetic Retinopathy 12 15 71
High Risk Non Proliferative Diabetic Retinopathy 12
Severe Npdr 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8946
ICD9CM 34 362.06
UMLS 71 C0730278

Summaries for Severe Nonproliferative Diabetic Retinopathy

MalaCards based summary : Severe Nonproliferative Diabetic Retinopathy, also known as high risk non proliferative diabetic retinopathy, is related to microvascular complications of diabetes 1 and microvascular complications of diabetes 5. An important gene associated with Severe Nonproliferative Diabetic Retinopathy is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are p70S6K Signaling and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Severe Nonproliferative Diabetic Retinopathy

Diseases related to Severe Nonproliferative Diabetic Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 1 30.0 VEGFA INS ICAM1 CCL2 AKR1B1
2 microvascular complications of diabetes 5 29.0 VEGFA PRKCB PGF INS ICAM1 ALB
3 diabetic macular edema 28.6 VEGFA REN PRKCB PGF ICAM1 CCL2
4 macular retinal edema 28.3 VEGFA PGF INS ICAM1 CCL2 ALB
5 background diabetic retinopathy 27.1 VEGFA PGF INS ICAM1 GADD45G CCL2
6 retroperitoneal hemangiopericytoma 10.5 VEGFA INS
7 acroosteolysis 10.4 VEGFA ALB
8 hypoglycemic coma 10.4 VEGFA INS
9 critical illness polyneuropathy 10.4 INS ALB
10 microvascular complications of diabetes 2 10.4
11 inflammatory and toxic neuropathy 10.4 INS ALB
12 polycystic kidney disease 4 10.4 REN ALB
13 heterophyiasis 10.4 ICAM1 ALB
14 mediastinitis 10.3 INS ALB
15 marasmus 10.3 INS ALB
16 decubitus ulcer 10.3 VEGFA INS ALB
17 chronic ulcer of skin 10.3 VEGFA INS ALB
18 idiopathic nephrotic syndrome 10.3 ALB ACE
19 hypoaldosteronism 10.3 REN ACE
20 renal artery obstruction 10.3 REN ACE
21 granulomatous hepatitis 10.3 ALB ACE
22 hair disease 10.3 VEGFA INS ALB
23 idiopathic edema 10.3 INS ACE
24 hypertension, diastolic 10.3 REN ACE
25 kwashiorkor 10.3 INS ALB
26 rheumatoid vasculitis 10.2 REN ICAM1
27 benign essential hypertension 10.2 REN INS ALB
28 hepatic vascular disease 10.2 VEGFA REN ALB
29 cholesterol embolism 10.2 REN ACE
30 corneal disease 10.2 VEGFA ALB AKR1B1
31 macular dystrophy, dominant cystoid 10.2 VEGFA PRKCB ACE
32 parathyroid gland disease 10.2 REN INS ALB
33 hypertensive nephropathy 10.2 VEGFA ALB ACE
34 papilledema 10.2 VEGFA ALB ACE
35 constrictive pericarditis 10.2 ALB ACE
36 pulmonary artery disease 10.2 VEGFA ALB ACE
37 drug allergy 10.2 INS ALB ACE
38 maturity-onset diabetes of the young, type 1 10.2 INS ALB ACE
39 aspiration pneumonia 10.2 INS ALB ACE
40 exanthem 10.2 VEGFA ALB ACE
41 malignant essential hypertension 10.2 REN ACE
42 sexual disorder 10.2 INS ALB ACE
43 fibromuscular dysplasia 10.2 REN ACE
44 potter's syndrome 10.1 REN INS ACE
45 orthostatic proteinuria 10.1 REN ALB ACE
46 hyperthyroidism 10.1 REN INS ALB
47 kidney papillary necrosis 10.1 REN ALB ACE
48 renal artery disease 10.1 REN ALB ACE
49 cardiac tamponade 10.1 REN ALB ACE
50 chronic pyelonephritis 10.1 REN ALB ACE

Graphical network of the top 20 diseases related to Severe Nonproliferative Diabetic Retinopathy:



Diseases related to Severe Nonproliferative Diabetic Retinopathy

Symptoms & Phenotypes for Severe Nonproliferative Diabetic Retinopathy

GenomeRNAi Phenotypes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ACE APOB CCDC144NL GADD45G ICAM1 REN
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ACE APOB CCDC144NL GADD45G ICAM1 REN

MGI Mouse Phenotypes related to Severe Nonproliferative Diabetic Retinopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACE ALB APOB ICAM1 INS PGF
2 homeostasis/metabolism MP:0005376 9.9 ACE AKR1B1 ALB APOB GADD45G ICAM1
3 immune system MP:0005387 9.7 ACE ALB APOB CCL2 GADD45G ICAM1
4 renal/urinary system MP:0005367 9.17 ACE AKR1B1 ALB GADD45G INS REN

Drugs & Therapeutics for Severe Nonproliferative Diabetic Retinopathy

Drugs for Severe Nonproliferative Diabetic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Inhibitors Phase 4
3 Antineoplastic Agents, Immunological Phase 4
4 Anesthetics Phase 4
5
Ranibizumab Approved Phase 3 347396-82-1 459903
6
Fenofibrate Approved Phase 3 49562-28-9 3339
7
Octreotide Approved, Investigational Phase 3 83150-76-9 6400441 383414
8 Hypolipidemic Agents Phase 3
9 Antimetabolites Phase 3
10 Lipid Regulating Agents Phase 3
11 Gastrointestinal Agents Phase 3
12 Antineoplastic Agents, Hormonal Phase 3
13
Triamcinolone Approved, Vet_approved 124-94-7 31307
14 Angiogenesis Inducing Agents
15 Triamcinolone diacetate
16 triamcinolone acetonide
17 Triamcinolone hexacetonide

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Prevention of Post-Photocoagulation Macular Edema by Intravitreal Bevacizumab. Completed NCT00801866 Phase 4 Bevacizumab
2 Effect of Adjunctive Intravitreal Bevacizumab Before Panretinal Photocoagulation in Macular Thickness and Retinal Nerve Fiber Layer Thickness Completed NCT01504724 Phase 4 bevacizumab
3 Evaluation of Ranibizumab on the Ease of Procedure and Complication Rate in Proliferative Diabetic Retinopathy (PDR) Requiring Vitrectomy Unknown status NCT00516464 Phase 3 Lucentis (ranibizumab)
4 A Phase 3, Double-Masked, Randomized Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients With Moderately Severe to Severe Nonproliferative Diabetic Retinopathy Completed NCT02718326 Phase 3 Intravitreal aflibercept injection [IAI];Sham
5 Effects of Fenofibrate Administration in Patients With Diabetic Nephropathy Recruiting NCT03869931 Phase 3 Fenofibrate
6 An Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Octreotide Acetate in Microspheres in the Therapy of Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy (NPDR) or Low Risk Proliferative Diabetic Retinopathy (PDR) Terminated NCT00248157 Phase 3 Octreotide acetate in microspheres
7 An Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Octreotide Acetate in Microspheres in the Therapy of Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy (NPDR) or Low Risk Proliferative Diabetic Retinopathy (PDR) Terminated NCT00248131 Phase 3 Octreotide acetate in microspheres
8 A Randomized, Double-masked, Multicenter, Placebo Controlled Study of Keluo Xin Capsule on Efficacy and Safety in Patients With Diabetic Retinopathy Not yet recruiting NCT03258242 Phase 2 Keluo Xin capsule;Placebo oral capsule
9 Pascal Pan Retinal Photo-Stimulation in Pre-Proliferative Diabetic Retinopathy: a Safety and Efficacy Study Unknown status NCT02309502
10 Panretinal Photocoagulation (PRP) vs PRP Combined With Intravitreous Conbercept (IVC) for Severe Nonproliferative Diabetic Retinopathy (nPDR): A Randomized Clinical Trial Recruiting NCT03863535 Conbercept
11 Analysis of Angiogenic Protein and Anti-angiogenic Levels in Eyes With Diabetic Retinopathy. Recruiting NCT02026843

Search NIH Clinical Center for Severe Nonproliferative Diabetic Retinopathy

Genetic Tests for Severe Nonproliferative Diabetic Retinopathy

Anatomical Context for Severe Nonproliferative Diabetic Retinopathy

MalaCards organs/tissues related to Severe Nonproliferative Diabetic Retinopathy:

40
Eye, Endothelial, Retina, Kidney, Skin

Publications for Severe Nonproliferative Diabetic Retinopathy

Articles related to Severe Nonproliferative Diabetic Retinopathy:

(show top 50) (show all 256)
# Title Authors PMID Year
1
Total Protein Concentration and Tumor Necrosis Factor α in Tears of Nonproliferative Diabetic Retinopathy. 61
31834153 2019
2
Optical coherence tomography angiography findings of type 1 diabetic patients with diabetic retinopathy, in comparison with type 2 patients. 61
31832768 2019
3
Changing trends in the prevalence of diabetic retinopathy in type 1 diabetes mellitus from 1990 to 2018: A retrospective study in a Portuguese population. 61
31669626 2019
4
Widefield OCT-Angiography and Fluorescein Angiography Assessments of Nonperfusion in Diabetic Retinopathy and Edema Treated with Anti-Vascular Endothelial Growth Factor. 61
31383483 2019
5
Quantitative Ultra-Widefield Angiography and Diabetic Retinopathy Severity: An Assessment of Panretinal Leakage Index, Ischemic Index and Microaneurysm Count. 61
31383482 2019
6
Automatic Detection of Diabetic Retinopathy in Retinal Fundus Photographs Based on Deep Learning Algorithm. 61
31737428 2019
7
MicroRNAs as biomarkers of diabetic retinopathy and disease progression. 61
31290435 2019
8
Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device. 61
31720980 2019
9
Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy. 61
31016437 2019
10
Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy. 61
31622467 2019
11
An Evaluation System of Fundus Photograph-Based Intelligent Diagnostic Technology for Diabetic Retinopathy and Applicability for Research. 61
31290125 2019
12
Beyond vision loss: the independent impact of diabetic retinopathy on vision-related quality of life in a Chinese Singaporean population. 61
30361276 2019
13
MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus. 61
31546259 2019
14
EVALUATION OF MULTISPECTRAL IMAGING IN DIAGNOSING DIABETIC RETINOPATHY. 61
29901495 2019
15
Use of Telehealth Screening to Detect Diabetic Retinopathy and Other Ocular Findings in Primary Care Settings. 61
30481134 2019
16
Retinal vasculature-function correlation in non-proliferative diabetic retinopathy. 61
31552568 2019
17
Effects of panretinal photocoagulation on retinal vasculature and foveal avascular zone in diabetic retinopathy using optical coherence tomography angiography: A pilot study. 61
31528763 2019
18
Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Retinopathy: Consequences of Inadvertent Treatment Interruptions. 61
30878488 2019
19
The diagnostic accuracy of an intelligent and automated fundus disease image assessment system with lesion quantitative function (SmartEye) in diabetic patients. 61
31412800 2019
20
Macular vessels density in diabetic retinopathy: quantitative assessment using optical coherence tomography angiography. 61
30194547 2019
21
Central retinal thickness following panretinal photocoagulation using a multispot semi-automated pattern-scanning laser to treat ischaemic diabetic retinopathy: Treatment in one session compared with four monthly sessions. 61
30561087 2019
22
The estimated healthcare cost of diabetic retinopathy in Indonesia and its projection for 2025. 61
31285276 2019
23
Optical coherence tomography angiography analysis of the choriocapillary layer in treatment-naïve diabetic eyes. 61
31089870 2019
24
Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation. 61
31192968 2019
25
Alteration of choroidal vascular structure in diabetic retinopathy. 61
31177190 2019
26
Retinal Nonperfusion Characteristics on Ultra-Widefield Angiography in Eyes With Severe Nonproliferative Diabetic Retinopathy and Proliferative Diabetic Retinopathy. 61
30973596 2019
27
Quantitative analysis of retinal and choroid capillary ischaemia using optical coherence tomography angiography in type 2 diabetes. 61
30810284 2019
28
Impact of Diabetic Retinopathy on Sleep, Mood, and Quality of Life. 61
31117122 2019
29
Validation of Smartphone-Based Retinal Photography for Diabetic Retinopathy Screening. 61
31100178 2019
30
Factors Associated With Visual Acuity and Central Subfield Thickness Changes When Treating Diabetic Macular Edema With Anti-Vascular Endothelial Growth Factor Therapy: An Exploratory Analysis of the Protocol T Randomized Clinical Trial. 61
30676635 2019
31
Macular Capillary Perfusion in Chinese Patients With Diabetic Retinopathy Obtained With Optical Coherence Tomography Angiography. 61
30998251 2019
32
[Frequency and severity of diabetic retinopathy in patients with type 2 diabetes mellitus at the Regional Institute of Ophthalmology]. 61
31460638 2019
33
Sensitivity and Specificity of Smartphone-Based Retinal Imaging for Diabetic Retinopathy: A Comparative Study. 61
31014763 2019
34
Microaneurysm turnover is a predictor of diabetic retinopathy progression. 61
29699981 2019
35
Safety of Trypan Blue Capsule Staining to Corneal Endothelium in Patients with Diabetic Retinopathy. 61
31032113 2019
36
Association of urinary albumin excretion with central foveal thickness and intravitreal conbercept treatment frequency in patients with diabetic macular edema. 61
31637196 2019
37
Retinopathy progression and the risk of end-stage kidney disease: results from a longitudinal Japanese cohort of 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease. 61
31798893 2019
38
Morphometry of the normal retinal periarteral capillary-free zone and changes during severe nonproliferative diabetic retinopathy. 61
30829616 2019
39
Evaluation Of The Timing Of Intravitreal Bevacizumab Injection As Adjuvant Therapy To Panretinal Photocoagulation In Patients With Diabetic Macular Edema Secondary To Diabetic Retinopathy. 61
31576109 2019
40
Teleophthalmology: a strategy for timely diagnosis of sight-threatening diabetic retinopathy in primary care, Concepción, Chile. 61
31544045 2019
41
Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography. 61
30550612 2018
42
Alteration of layer thickness in the choroid of diabetic patients. 61
29740913 2018
43
Changes in choriocapillaris and retinal morphology after laser photocoagulation by OCT angiography: A case report. 61
30431615 2018
44
Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography. 61
30326063 2018
45
Self-reported healthcare utilization by adults with diabetic retinopathy in the United States. 61
29958092 2018
46
Ranibizumab Induces Regression of Diabetic Retinopathy in Most Patients at High Risk of Progression to Proliferative Diabetic Retinopathy. 61
31047503 2018
47
Diet soft drink is associated with increased odds of proliferative diabetic retinopathy. 61
29360260 2018
48
Quantitative evaluation of optical coherence tomography angiography images of diabetic retinopathy eyes before and after removal of projection artifacts. 61
29660256 2018
49
A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation. 61
30237467 2018
50
Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes. 61
30108264 2018

Variations for Severe Nonproliferative Diabetic Retinopathy

Expression for Severe Nonproliferative Diabetic Retinopathy

Search GEO for disease gene expression data for Severe Nonproliferative Diabetic Retinopathy.

Pathways for Severe Nonproliferative Diabetic Retinopathy

Pathways related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 REN PRKCB PGF INS CCL2 ACE
2
Show member pathways
12.39 VEGFA PRKCB ICAM1 CCL2
3 12.32 VEGFA PRKCB PGF INS GADD45G
4
Show member pathways
12.01 VEGFA PRKCB ICAM1 CCL2
5 11.82 VEGFA INS ALB
6 11.67 VEGFA ICAM1 CCL2
7 11.62 VEGFA PRKCB INS
8 11.51 VEGFA ICAM1 CCL2
9
Show member pathways
11.35 INS ICAM1 CCL2 APOB ALB
10 11.26 VEGFA PRKCB ICAM1 CCL2
11 10.77 VEGFA CCL2
12
Show member pathways
10.68 VEGFA PGF
13 10.66 ICAM1 CCL2

GO Terms for Severe Nonproliferative Diabetic Retinopathy

Cellular components related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 VEGFA REN PGF INS CCL2 APOB
2 extracellular space GO:0005615 9.32 VEGFA REN PGF INS ICAM1 CCL2
3 endosome lumen GO:0031904 9.16 INS APOB

Biological processes related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.61 VEGFA REN ACE
2 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.49 VEGFA PRKCB
3 lipoprotein transport GO:0042953 9.48 PRKCB APOB
4 vascular endothelial growth factor signaling pathway GO:0038084 9.46 VEGFA PGF
5 response to organic substance GO:0010033 9.43 REN APOB AKR1B1
6 amyloid-beta metabolic process GO:0050435 9.4 REN ACE
7 induction of positive chemotaxis GO:0050930 9.37 VEGFA PGF
8 angiotensin maturation GO:0002003 9.32 REN ACE
9 positive regulation of mast cell chemotaxis GO:0060754 9.16 VEGFA PGF
10 negative regulation of protein oligomerization GO:0032460 8.96 INS ALB
11 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.62 VEGFA ACE

Molecular functions related to Severe Nonproliferative Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.96 REN INS
2 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFA PGF

Sources for Severe Nonproliferative Diabetic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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