MCID: SXC001
MIFTS: 47

Sex Cord-Gonadal Stromal Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Sex Cord-Gonadal Stromal Tumor

MalaCards integrated aliases for Sex Cord-Gonadal Stromal Tumor:

Name: Sex Cord-Gonadal Stromal Tumor 12 15 17
Malignant Testicular Sex Cord-Stromal Tumor 71
Sex Cord Stromal Tumor of Testis 71
Sex Cord-Gonadal Stromal Tumour 12
Sex Cord-Gonadal Stromal Tumors 44
Specialized Gonadal Neoplasm 12
Specialized Gonadal Tumour 12
Sex Cord-Stromal Neoplasm 12
Specialized Gonadal Tumor 12
Sex Cord Stromal Tumour 12
Sex Cord-Stromal Tumor 71

Classifications:



External Ids:

Disease Ontology 12 DOID:192
MeSH 44 D018312
NCIt 50 C3794
SNOMED-CT 67 253028001
UMLS 71 C0206724 C1515289 C3840076

Summaries for Sex Cord-Gonadal Stromal Tumor

Disease Ontology : 12 A reproductive organ cancer that is located in the sex cord-derived tissues of the ovary or testis and derives from granulosa cells, Leydig cells, Sertoli cells, and fibroblasts.

MalaCards based summary : Sex Cord-Gonadal Stromal Tumor, also known as malignant testicular sex cord-stromal tumor, is related to gynandroblastoma and leydig cell tumor. An important gene associated with Sex Cord-Gonadal Stromal Tumor is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcription_CREM signaling in testis. The drugs Bevacizumab and Fulvestrant have been mentioned in the context of this disorder. Affiliated tissues include sex cord-derived tissues of the ovary, testis and ovary, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 74 Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and... more...

Related Diseases for Sex Cord-Gonadal Stromal Tumor

Diseases related to Sex Cord-Gonadal Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 32.2 VIM FOXL2 DICER1 CALB2
2 leydig cell tumor 32.1 NR5A1 INHA GNAS CALB2 AFP
3 ovarian sex-cord stromal tumor 31.3 WT1 NR5A1 MLANA KRT7 FOXL2 DICER1
4 sertoli-leydig cell tumor 31.1 WT1 PGR MUC1 KRT7 INHA DICER1
5 fibroma 30.8 VIM KRT7 CALB2
6 sertoli cell tumor 30.7 WT1 VIM PRKAR1A PGR NR5A1 MUC1
7 gonadoblastoma 30.2 WT1 NR5A1 FOXL2 ALPP
8 dysgerminoma 30.2 WT1 KRT7 INHA ALPP AFP
9 microcystic stromal tumor 30.2 WT1 NR5A1 FOXL2 DICER1
10 testicular sex cord-stromal neoplasm 11.4
11 ovarian fibroma 11.3
12 fallopian tube carcinosarcoma 10.5 WT1 CALB2
13 scrotum paget's disease 10.4 MUC1 KRT7
14 epithelial predominant wilms' tumor 10.4 WT1 KRT7
15 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
16 microinvasive cervical squamous cell carcinoma 10.4 WT1 KRT7
17 spindle cell thymoma 10.4 MUC1 CALB2
18 nephrogenic adenofibroma 10.4 WT1 KRT7
19 twinning, dizygotic 10.4 INHA FSHR
20 bartholin's gland adenoid cystic carcinoma 10.4 PGR KRT7
21 lung sarcoma 10.4 NKX2-1 CALB2
22 chronic tympanitis 10.4 PGR MUC1
23 peritoneal benign neoplasm 10.4 PGR CALB2
24 liver fibroma 10.4 VIM CALB2
25 papillary tumor of the pineal region 10.4 VIM MUC1
26 mucinous intrahepatic cholangiocarcinoma 10.4 MUC1 KRT7
27 middle ear adenoma 10.4 MUC1 KRT7
28 lipid-rich breast carcinoma 10.4 PGR MUC1
29 malignant epithelial mesothelioma 10.4 CEACAM5 CALB2
30 mucinous cystadenofibroma 10.4 MUC1 FSHR
31 oncocytic breast carcinoma 10.4 PGR KRT7
32 lymphangiomatosis 10.4 VIM PGR
33 leukoplakia of penis 10.4 KRT7 CEACAM5
34 ovarian large-cell neuroendocrine carcinoma 10.4 WT1 KRT7
35 breast scirrhous carcinoma 10.4 PGR MUC1
36 mucinous adenofibroma 10.4 KRT7 CEACAM5
37 primary hepatic neuroendocrine carcinoma 10.4 VIM ALPP
38 congenital epulis 10.4 VIM PGR
39 malignant acrospiroma 10.4 KRT7 CEACAM5
40 papillary thymic adenocarcinoma 10.4 CEACAM5 CALB2
41 wolffian duct adenocarcinoma 10.4 WT1 KRT7 CALB2
42 lipoadenoma 10.4 MUC1 KRT7
43 pancreatic serous cystadenocarcinoma 10.4 KRT7 CEACAM5
44 malignant biphasic mesothelioma 10.4 WT1 CALB2
45 epithelioid cell synovial sarcoma 10.4 WT1 KRT7 CALB2
46 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
47 fallopian tube endometriosis 10.3 PGR CEACAM5
48 vulva adenocarcinoma 10.3 KRT7 CEACAM5
49 vulvar eccrine porocarcinoma 10.3 MUC1 CEACAM5
50 vaginal tubulovillous adenoma 10.3 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Sex Cord-Gonadal Stromal Tumor:



Diseases related to Sex Cord-Gonadal Stromal Tumor

Symptoms & Phenotypes for Sex Cord-Gonadal Stromal Tumor

GenomeRNAi Phenotypes related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 AFP DICER1 FSHR GNAS INHBA KRT7

MGI Mouse Phenotypes related to Sex Cord-Gonadal Stromal Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 AFP CALB2 DICER1 FSHR GNAS INHBA
2 endocrine/exocrine gland MP:0005379 10.18 AFP DICER1 FOXL2 FSHR GNAS INHA
3 homeostasis/metabolism MP:0005376 10.17 AFP DICER1 FOXL2 FSHR GNAS INHA
4 neoplasm MP:0002006 9.91 AFP DICER1 FSHR GNAS INHA NKX2-1
5 normal MP:0002873 9.73 CALB2 DICER1 FOXL2 GNAS INHA INHBA
6 no phenotypic analysis MP:0003012 9.7 DICER1 FOXL2 GNAS MLANA NKX2-1 PGR
7 reproductive system MP:0005389 9.44 AFP DICER1 FOXL2 FSHR INHA INHBA

Drugs & Therapeutics for Sex Cord-Gonadal Stromal Tumor

Drugs for Sex Cord-Gonadal Stromal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
3
nivolumab Approved Phase 2 946414-94-4
4
Ipilimumab Approved Phase 2 477202-00-9
5
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
6
Etoposide Approved Phase 2 33419-42-0 36462
7
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
8
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
9
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
10 Angiogenesis Inhibitors Phase 2
11 Immunoglobulin G Phase 2
12 Mitogens Phase 2
13 Immunologic Factors Phase 2
14 Immunoglobulins, Intravenous Phase 2
15 Endothelial Growth Factors Phase 2
16 Antineoplastic Agents, Immunological Phase 2
17 Immunoglobulins Phase 2
18 Antibodies Phase 2
19 Antibodies, Monoclonal Phase 2
20 Hormones Phase 2
21 Estrogen Antagonists Phase 2
22 Estrogens Phase 2
23 Hormone Antagonists Phase 2
24 Estrogen Receptor Antagonists Phase 2
25 Antineoplastic Agents, Hormonal Phase 2
26 Albumin-Bound Paclitaxel Phase 2
27 Tubulin Modulators Phase 2
28 Antimitotic Agents Phase 2
29 Antibiotics, Antitubercular Phase 2
30 Etoposide phosphate Phase 2
31 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Prospective, Randomized Trial Comparing Paclitaxel and Carboplatin or Bleomycin, Etoposide and Cisplatin in the Treatment of Ovarian Malignant Sex Cord-Stromal Tumors Recruiting NCT02429700 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
2 A Randomized, Open Label, Phase II Trial of Bevacizumab Plus Weekly Paclitaxel Followed by Bevacizumab Monotherapy Maintenance Versus Weekly Paclitaxel Followed by Observation in Patients With Relapsed Ovarian Sex-cord Stromal Tumours Unknown status NCT01770301 Phase 2 Paclitaxel;Bevacizumab
3 A Phase II Trial of NCI-Supplied Agent: Bevacizumab (rhuMAB VEGF) (NSC# 704865) for Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
4 Phase II Study of Paclitaxel for Ovarian Stromal Tumors as Second-Line Therapy Completed NCT00006227 Phase 2 Paclitaxel
5 An Open-label, Single Arm, Prospective, Multi-center, Tandem Two Stage Designed, Phase II Study to Evaluate the Efficacy of Fulvestrant in Women With Recurrent/Metastatic Estrogen Receptor Positive Gynecological Malignancies Recruiting NCT03926936 Phase 2 Fulvestrant
6 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
7 A Randomized Phase II Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
8 DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood Completed NCT01572467
9 Living After a Rare Cancer of the Ovary: Chronic Fatigue, Quality of Life and Late Effects of Chemotherapy Recruiting NCT03418844

Search NIH Clinical Center for Sex Cord-Gonadal Stromal Tumor

Cochrane evidence based reviews: sex cord-gonadal stromal tumors

Genetic Tests for Sex Cord-Gonadal Stromal Tumor

Anatomical Context for Sex Cord-Gonadal Stromal Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Sex Cord-Gonadal Stromal Tumor:

19
Sex Cord-Derived Tissues Of The Ovary

MalaCards organs/tissues related to Sex Cord-Gonadal Stromal Tumor:

40
Testis, Ovary, Endothelial, Pituitary, Thyroid, Adrenal Gland

Publications for Sex Cord-Gonadal Stromal Tumor

Articles related to Sex Cord-Gonadal Stromal Tumor:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome. 6
24855271 2014
2
Activating mutations of the stimulatory g protein in juvenile ovarian granulosa cell tumors: a new prognostic factor? 6
16507630 2006
3
Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations. 6
12970318 2003
4
Cushing's syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene. 6
12727968 2003
5
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. 6
9626141 1998
6
Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. 6
8766942 1996
7
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. 6
7739708 1995
8
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. 6
1594625 1992
9
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. 6
1944469 1991
10
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. 6
2549426 1989
11
The McCune-Albright syndrome: a lethal gene surviving by mosaicism. 6
3720010 1986
12
Leydig cell ovarian tumor - clinical case description and literature review. 61
33100950 2020
13
Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. 54
19033865 2009
14
Calretinin: diagnostic utility in the female genital tract. 54
19550372 2009
15
Sex cord-gonadal stromal tumor of the rete testis. 61
19125206 2009
16
SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. 54
18753972 2008
17
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. 54
17885486 2007
18
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. 54
17721194 2007
19
CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. 54
17581419 2007
20
[Immunohistochemical sex cord markers. Description and use in the differential diagnosis of ovarian tumors]. 54
17429635 2007
21
Incompletely differentiated (unclassified) sex cord/gonadal stromal tumor of the testis with a "pure" spindle cell component: report of a case with diagnostic and histogenetic considerations. 61
17850986 2007
22
The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors. 54
15754297 2005
23
The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis. 54
16512598 2005
24
Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. 54
15626916 2005
25
High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia. 54
15623622 2004
26
An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. 54
15381902 2004
27
Inhibins as biomarkers for reproductive cancers. 54
15319824 2004
28
[Ovarian tumors with endocrine function]. 54
15256111 2004
29
Neuropeptide Y receptor expression in human primary ovarian neoplasms. 54
14631382 2004
30
Sclerosing stromal tumors of the ovary: a clinicopathologic, immunohistochemical and cytogenetic analysis of three cases. 54
15032299 2004
31
Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin. 54
12808064 2003
32
Ovarian steroid cell tumors: an immunohistochemical study including a comparison of calretinin with inhibin. 54
12649671 2003
33
Inhibin immunohistochemical staining: a practical approach for the surgical pathologist in the diagnoses of ovarian sex cord-stromal tumors. 54
12502966 2003
34
Expression of calretinin in human ovary, testis, and ovarian sex cord-stromal tumors. 54
11603218 2001
35
Value of inhibin staining in gynecological pathology. 54
11192074 2001
36
No evidence of somatic activating mutations on gonadotropin receptor genes in sex cord stromal tumors. 54
11056247 2000
37
Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors. 54
10747314 2000
38
Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. 54
10414506 1999
39
Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. 54
9720507 1998
40
CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis. 54
9720506 1998
41
Müllerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. 54
9712426 1998
42
Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. 54
9656124 1998
43
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. 54
9591732 1998
44
Inhibin and epithelial membrane antigen immunohistochemistry assist in the diagnosis of sex cord-stromal tumors and provide clues to the histogenesis of hypercalcemic small cell carcinomas. 54
9475192 1998
45
An enormous testicular sex cord/gonadal stromal tumor. 61
8811574 1996
46
Immunohistochemical localization of Ad4-binding protein with correlation to steroidogenic enzyme expression in cycling human ovaries and sex cord stromal tumors. 54
7673429 1995
47
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor. 54
7997239 1994
48
Histogenetic consideration of ovarian sex cord-stromal tumors analyzed by expression pattern of cytokeratins, vimentin, and laminin. Correlation studies with human gonads. 54
7527534 1994
49
Response of metastasized sex cord gonadal stromal tumor of the testis to cisplatin-based chemotherapy. 61
7510344 1994
50
Immunohistochemical phenotype of ovarian granulosa cell tumors: absence of epithelial membrane antigen has diagnostic value. 54
8314261 1994

Variations for Sex Cord-Gonadal Stromal Tumor

ClinVar genetic disease variations for Sex Cord-Gonadal Stromal Tumor:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 GNAS NM_000516.6(GNAS):c.601C>T (p.Arg201Cys) SNV Pathogenic 15933 rs11554273 20:57484420-57484420 20:58909365-58909365
2 GNAS NM_000516.6(GNAS):c.602G>A (p.Arg201His) SNV Pathogenic 15934 rs121913495 20:57484421-57484421 20:58909366-58909366

Cosmic variations for Sex Cord-Gonadal Stromal Tumor:

9 (show top 50) (show all 96)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM99815457 SPEN ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.9338G>A p.R3113Q 1:15935578-15935578 6
2 COSM91859752 KRAS ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.35G>T p.G12V 12:25245350-25245350 6
3 COSM134614978 KRAS ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.35G>T p.G12V 12:25245350-25245350 6
4 COSM134990158 KRAS ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.35G>T p.G12V 12:25245350-25245350 6
5 COSM87804055 KRAS ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.35G>T p.G12V 12:25245350-25245350 6
6 COSM150806731 KDR ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.1372T>G p.W458G 4:55107777-55107777 6
7 COSM87033244 KDR ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.1372T>G p.W458G 4:55107777-55107777 6
8 COSM89404125 FOXL2 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.402C>G p.C134W 3:138946321-138946321 6
9 COSM92463160 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5428G>T p.D1810Y 14:95091302-95091302 6
10 COSM128908209 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5113G>A p.E1705K 14:95094139-95094139 6
11 COSM99956165 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5439G>C p.E1813D 14:95091291-95091291 6
12 COSM92465015 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5437G>C p.E1813Q 14:95091293-95091293 6
13 COSM127764798 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5125G>A p.D1709N 14:95094127-95094127 6
14 COSM92462429 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5113G>A p.E1705K 14:95094139-95094139 6
15 COSM128908230 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5439G>C p.E1813D 14:95091291-95091291 6
16 COSM131473380 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5113G>A p.E1705K 14:95094139-95094139 6
17 COSM127764998 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5428G>A p.D1810N 14:95091302-95091302 6
18 COSM134823880 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.1807G>A p.E603K 14:95094139-95094139 6
19 COSM134823943 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2132A>C p.E711A 14:95091292-95091292 6
20 COSM99956457 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5125G>A p.D1709N 14:95094127-95094127 6
21 COSM128911758 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5437G>C p.E1813Q 14:95091293-95091293 6
22 COSM131473612 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5125G>A p.D1709N 14:95094127-95094127 6
23 COSM134825030 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2131G>C p.E711Q 14:95091293-95091293 6
24 COSM99956147 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5113G>A p.E1705K 14:95094139-95094139 6
25 COSM131477892 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5127T>A p.D1709E 14:95094125-95094125 6
26 COSM134825443 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.1821T>A p.D607E 14:95094125-95094125 6
27 COSM92462640 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5125G>A p.D1709N 14:95094127-95094127 6
28 COSM134824018 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.1819G>A p.D607N 14:95094127-95094127 6
29 COSM127764510 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5113G>A p.E1705K 14:95094139-95094139 6
30 COSM131473400 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5365-182G>C p.? 14:95091291-95091291 6
31 COSM128908220 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5438A>G p.E1813G 14:95091292-95091292 6
32 COSM134824008 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2122G>C p.D708H 14:95091302-95091302 6
33 COSM127767697 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5437G>C p.E1813Q 14:95091293-95091293 6
34 COSM127764521 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5438A>G p.E1813G 14:95091292-95091292 6
35 COSM99958835 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5437G>C p.E1813Q 14:95091293-95091293 6
36 COSM131476604 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5365-184G>C p.? 14:95091293-95091293 6
37 COSM128908575 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5125G>A p.D1709N 14:95094127-95094127 6
38 COSM134823886 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2132A>G p.E711G 14:95091292-95091292 6
39 COSM99957014 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5428G>T p.D1810Y 14:95091302-95091302 6
40 COSM92462443 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5439G>C p.E1813D 14:95091291-95091291 6
41 COSM134824218 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2122G>T p.D708Y 14:95091302-95091302 6
42 COSM92470802 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5126A>T p.D1709V 14:95094126-95094126 6
43 COSM127764780 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5437G>A p.E1813K 14:95091293-95091293 6
44 COSM128908518 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5437G>A p.E1813K 14:95091293-95091293 6
45 COSM92462437 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5438A>G p.E1813G 14:95091292-95091292 6
46 COSM127764790 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5428G>C p.D1810H 14:95091302-95091302 6
47 COSM99956156 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5438A>G p.E1813G 14:95091292-95091292 6
48 COSM131473389 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.5365-183A>G p.? 14:95091292-95091292 6
49 COSM134823927 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2133G>C p.E711D 14:95091291-95091291 6
50 COSM134824162 DICER1 ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour c.2133G>T p.E711D 14:95091291-95091291 6

Expression for Sex Cord-Gonadal Stromal Tumor

Search GEO for disease gene expression data for Sex Cord-Gonadal Stromal Tumor.

Pathways for Sex Cord-Gonadal Stromal Tumor

Pathways related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.48 WT1 VIM INHBA ALPP AFP
2 10.69 PRKAR1A GNAS FSHR
3 10.43 PGR NR5A1 INHA FSHR

GO Terms for Sex Cord-Gonadal Stromal Tumor

Cellular components related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inhibin A complex GO:0043512 8.62 INHBA INHA

Biological processes related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 WT1 VIM NR5A1 NKX2-1 INHBA
2 gonad development GO:0008406 9.55 WT1 FSHR
3 cellular response to follicle-stimulating hormone stimulus GO:0071372 9.52 INHBA FSHR
4 positive regulation of male gonad development GO:2000020 9.51 WT1 NR5A1
5 sex determination GO:0007530 9.49 WT1 NR5A1
6 negative regulation of macrophage differentiation GO:0045650 9.48 INHBA INHA
7 hemoglobin biosynthetic process GO:0042541 9.46 INHBA INHA
8 SMAD protein signal transduction GO:0060395 9.46 VIM INHBA INHA AFP
9 ovulation from ovarian follicle GO:0001542 9.43 PGR AFP
10 positive regulation of follicle-stimulating hormone secretion GO:0046881 9.4 INHBA INHA
11 negative regulation of B cell differentiation GO:0045578 9.37 INHBA INHA
12 negative regulation of female gonad development GO:2000195 9.32 WT1 NR5A1
13 negative regulation of follicle-stimulating hormone secretion GO:0046882 9.26 INHBA INHA
14 ovarian follicle development GO:0001541 9.26 INHBA INHA FSHR FOXL2
15 male gonad development GO:0008584 9.02 WT1 NR5A1 INHBA INHA FSHR

Molecular functions related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 WT1 VIM PRKAR1A PGR PDE11A NR5A1
2 sequence-specific DNA binding GO:0043565 9.35 WT1 PGR NR5A1 NKX2-1 FOXL2
3 inhibin binding GO:0034711 8.62 INHBA INHA

Sources for Sex Cord-Gonadal Stromal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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