Sex Cord-Gonadal Stromal Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SXC001 MIFTS: 47	Sex Cord-Gonadal Stromal Tumor Categories: Cancer diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Sex Cord-Gonadal Stromal Tumor

MalaCards integrated aliases for Sex Cord-Gonadal Stromal Tumor:

Name: Sex Cord-Gonadal Stromal Tumor ¹² ¹⁵ ¹⁷

Malignant Testicular Sex Cord-Stromal Tumor ⁷¹

Sex Cord Stromal Tumor of Testis ⁷¹

Sex Cord-Gonadal Stromal Tumour ¹²

Sex Cord-Gonadal Stromal Tumors ⁴⁴

Specialized Gonadal Neoplasm ¹²

Specialized Gonadal Tumour ¹²

Sex Cord-Stromal Neoplasm ¹²

Specialized Gonadal Tumor ¹²

Sex Cord Stromal Tumour ¹²

Sex Cord-Stromal Tumor ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:192

MeSH ⁴⁴ D018312

NCIt ⁵⁰ C3794

SNOMED-CT ⁶⁷ 253028001

EFO ¹⁷ EFO_0007483

UMLS ⁷¹ C0206724 C1515289 C3840076

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Summaries for Sex Cord-Gonadal Stromal Tumor

Disease Ontology : ¹² A reproductive organ cancer that is located in the sex cord-derived tissues of the ovary or testis and derives from granulosa cells, Leydig cells, Sertoli cells, and fibroblasts.

MalaCards based summary : Sex Cord-Gonadal Stromal Tumor, also known as malignant testicular sex cord-stromal tumor, is related to gynandroblastoma and leydig cell tumor. An important gene associated with Sex Cord-Gonadal Stromal Tumor is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcription_CREM signaling in testis. The drugs Bevacizumab and Fulvestrant have been mentioned in the context of this disorder. Affiliated tissues include sex cord-derived tissues of the ovary, testis and ovary, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : ⁷⁴ Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and... more...

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Related Diseases for Sex Cord-Gonadal Stromal Tumor

Diseases related to Sex Cord-Gonadal Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)

#	Related Disease	Score	Top Affiliating Genes
1	gynandroblastoma	32.2	VIM FOXL2 DICER1 CALB2
2	leydig cell tumor	32.1	NR5A1 INHA GNAS CALB2 AFP
3	ovarian sex-cord stromal tumor	31.3	WT1 NR5A1 MLANA KRT7 FOXL2 DICER1
4	sertoli-leydig cell tumor	31.1	WT1 PGR MUC1 KRT7 INHA DICER1
5	fibroma	30.8	VIM KRT7 CALB2
6	sertoli cell tumor	30.7	WT1 VIM PRKAR1A PGR NR5A1 MUC1
7	gonadoblastoma	30.2	WT1 NR5A1 FOXL2 ALPP
8	dysgerminoma	30.2	WT1 KRT7 INHA ALPP AFP
9	microcystic stromal tumor	30.2	WT1 NR5A1 FOXL2 DICER1
10	testicular sex cord-stromal neoplasm	11.4
11	ovarian fibroma	11.3
12	fallopian tube carcinosarcoma	10.5	WT1 CALB2
13	scrotum paget's disease	10.4	MUC1 KRT7
14	epithelial predominant wilms' tumor	10.4	WT1 KRT7
15	gallbladder signet ring cell adenocarcinoma	10.4	MUC1 KRT7
16	microinvasive cervical squamous cell carcinoma	10.4	WT1 KRT7
17	spindle cell thymoma	10.4	MUC1 CALB2
18	nephrogenic adenofibroma	10.4	WT1 KRT7
19	twinning, dizygotic	10.4	INHA FSHR
20	bartholin's gland adenoid cystic carcinoma	10.4	PGR KRT7
21	lung sarcoma	10.4	NKX2-1 CALB2
22	chronic tympanitis	10.4	PGR MUC1
23	peritoneal benign neoplasm	10.4	PGR CALB2
24	liver fibroma	10.4	VIM CALB2
25	papillary tumor of the pineal region	10.4	VIM MUC1
26	mucinous intrahepatic cholangiocarcinoma	10.4	MUC1 KRT7
27	middle ear adenoma	10.4	MUC1 KRT7
28	lipid-rich breast carcinoma	10.4	PGR MUC1
29	malignant epithelial mesothelioma	10.4	CEACAM5 CALB2
30	mucinous cystadenofibroma	10.4	MUC1 FSHR
31	oncocytic breast carcinoma	10.4	PGR KRT7
32	lymphangiomatosis	10.4	VIM PGR
33	leukoplakia of penis	10.4	KRT7 CEACAM5
34	ovarian large-cell neuroendocrine carcinoma	10.4	WT1 KRT7
35	breast scirrhous carcinoma	10.4	PGR MUC1
36	mucinous adenofibroma	10.4	KRT7 CEACAM5
37	primary hepatic neuroendocrine carcinoma	10.4	VIM ALPP
38	congenital epulis	10.4	VIM PGR
39	malignant acrospiroma	10.4	KRT7 CEACAM5
40	papillary thymic adenocarcinoma	10.4	CEACAM5 CALB2
41	wolffian duct adenocarcinoma	10.4	WT1 KRT7 CALB2
42	lipoadenoma	10.4	MUC1 KRT7
43	pancreatic serous cystadenocarcinoma	10.4	KRT7 CEACAM5
44	malignant biphasic mesothelioma	10.4	WT1 CALB2
45	epithelioid cell synovial sarcoma	10.4	WT1 KRT7 CALB2
46	cutaneous mucoepidermoid carcinoma	10.4	KRT7 CEACAM5
47	fallopian tube endometriosis	10.3	PGR CEACAM5
48	vulva adenocarcinoma	10.3	KRT7 CEACAM5
49	vulvar eccrine porocarcinoma	10.3	MUC1 CEACAM5
50	vaginal tubulovillous adenoma	10.3	KRT7 CEACAM5

Graphical network of the top 20 diseases related to Sex Cord-Gonadal Stromal Tumor:

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Symptoms & Phenotypes for Sex Cord-Gonadal Stromal Tumor

GenomeRNAi Phenotypes related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.17	AFP DICER1 FSHR GNAS INHBA KRT7

MGI Mouse Phenotypes related to Sex Cord-Gonadal Stromal Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.18	AFP CALB2 DICER1 FSHR GNAS INHBA
2	endocrine/exocrine gland	MP:0005379	10.18	AFP DICER1 FOXL2 FSHR GNAS INHA
3	homeostasis/metabolism	MP:0005376	10.17	AFP DICER1 FOXL2 FSHR GNAS INHA
4	neoplasm	MP:0002006	9.91	AFP DICER1 FSHR GNAS INHA NKX2-1
5	normal	MP:0002873	9.73	CALB2 DICER1 FOXL2 GNAS INHA INHBA
6	no phenotypic analysis	MP:0003012	9.7	DICER1 FOXL2 GNAS MLANA NKX2-1 PGR
7	reproductive system	MP:0005389	9.44	AFP DICER1 FOXL2 FSHR INHA INHBA

Sources

Drugs & Therapeutics for Sex Cord-Gonadal Stromal Tumor

Drugs for Sex Cord-Gonadal Stromal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

Anti-VEGF Humanized Monoclonal Antibody

anti-VEGF monoclonal antibody

Anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

rhuMAb-VEGF

Fulvestrant

Approved, Investigational

Phase 2

129453-61-8

104741 17756771

Synonyms:

(1S,9R,11S,14S,15S)-15-Methyl-9-[9-(4,4,5,5,5-pentafluoropentanesulphinyl)nonyl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-triene-5,14-diol

(7alpha,17beta)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol

(7R,13S,17S)-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

(7R,8S,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl) nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

(7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol

129453-61-8

7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol

7-(9-(4,4,5,5,5-Pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol

7alpha-(9-((4,4,5,5,5,-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol

7alpha-(9-((4,4,5,5,5-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol

7alpha-[9[(4,4,5,5,5-Pentafluropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3, 17 beta diol

AC1L2XEN

AC-4693

AstraZeneca brand of fulvestrant

BIDD:ER0348

BIDD:PXR0136

C070081

C32H47F5O3S

CCRIS 8741

CHEBI:404798

CHEMBL1358

CID104741

D01161

DB00947

Faslodex

Faslodex (TN)

Faslodex(ICI 182,780)

Faslodex, ICI 182780, Fulvestrant

fulvestrant

Fulvestrant

Fulvestrant (JAN/USAN/INN)

Fulvestrant [USAN]

HMS2090N22

HSDB 7658

I06-1109

ICI 182,780

ICI 182,789

Ici 182780

ICI-182780

LS-64781

NCGC00164789-02

nchembio.168-comp5

nchembio.76-comp5

nchembio775-comp4

NSC719276

S1191_Selleck

UNII-22X328QOC4

ZD 182780

ZD-182780

ZD-9238

ZM 182780

ZM-182780

nivolumab

Approved

Phase 2

946414-94-4

Ipilimumab

Approved

Phase 2

477202-00-9

Paclitaxel

Approved, Vet_approved

Phase 2

33069-62-4

36314

Synonyms:

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

157069-30-2

33069-62-4

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5Β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5Β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

7 Epi taxol

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.

7-epi-Paclitaxel

7-Epipaclitaxel

7-Epi-paclitaxel

7-epi-Taxol

7-Epitaxol

7-Epi-taxol

AB00513812

ABI 007

abi-007

ABI007

ABI-007

Abraxane

Abraxane (TN)

Abraxane I.V. Suspension

Abraxis BioScience brand of albumin-bound paclitaxel

AC1L1IOG

AC1L1VJI

AC1L9AVF

AC-675

ACon1_002231

albumin-bound paclitaxel

Ambotz33069-62-4

ANX-513

Anzatax

Asotax

BIDD:PXR0046

Bio-0076

Bio1_000362

Bio1_000851

Bio1_001340

Bio2_000416

Bio2_000896

BMS 181339-01

BMS-181339

BMS-181339-01

BPBio1_000320

BRD-A23723433-001-01-2

BRD-A28746609-001-04-0

BRD-K62008436-001-03-1

Bris taxol

Bristaxol

BSPBio_000290

BSPBio_001152

BSPBio_002614

C07394

C466458

C47H51NO14

Capxol

CCRIS 8143

CHEBI:103439

CHEBI:45863

CHEMBL100910

CHEMBL418410

CHEMBL48

CID36314

CID441276

CID4666

CID6713921

CID6915727

cMAP_000068

CPD-8718

D00491

DB01229

DHP-107

DHP-208

DivK1c_000441

DRG-0190

DTS-301

Ebetaxel

EmPAC

Epitaxol

EU-0101201

Genaxol

Genetaxyl

Genexol

Genexol-PM

HMS1362J13

HMS1568O12

HMS1792J13

HMS1922K08

HMS1990J13

HMS2090D07

HMS2093K15

HMS501G03

HSDB 6839

I06-0014

IDI1_000441

IDI1_002171

Intaxel

KBio1_000441

KBio2_000492

KBio2_002016

KBio2_002509

KBio2_003060

KBio2_004584

KBio2_005077

KBio2_005628

KBio2_007152

KBio2_007645

KBio3_000903

KBio3_000904

KBio3_001834

KBio3_002987

KBioGR_000492

KBioGR_001893

KBioGR_002509

KBioSS_000492

KBioSS_002016

KBioSS_002517

LipoPac

LMPR0104390001

Lopac0_001201

LS-31070

MBT 0206

MEGxp0_001940

Micellar Paclitaxel

Mitotax

MLS000863266

MLS001077297

MLS002154218

MLS002172439

MLS002695976

MolPort-001-742-627

MolPort-003-665-783

MolPort-003-932-365

MPI-5018

nab-paclitaxel

Nanotaxel

NCGC00024995-02

NCGC00024995-03

NCGC00024995-04

NCGC00024995-05

NCGC00024995-06

NCGC00024995-07

NCGC00164367-01

NCGC00164367-02

NCGC00164367-03

nchembio.188-comp1

nchembio.2007.34-comp9

nchembio.215-comp9

nchembio853-comp6

NCI60_000601

Neuro_000060

NINDS_000441

NK 105

Nova-12005

NP-010981

NSC 125973

NSC125973

NSC-125973

NSC358882

OAS-PAC-100

OncoGel

Onxal

Onxol

Onxol, Taxol, Nov-Onxol, Paclitaxel

P1632

Paclical

Pacligel

paclitaxel

Paclitaxel

Paclitaxel (JAN/USP)

Paclitaxel (JAN/USP/INN)

Paclitaxel (Taxol)

Paclitaxel [USAN:INN:BAN]

Paclitaxel, (4 alpha)-isomer

Paxceed

Paxene

Paxoral

Plaxicel

Praxel

Prestwick0_000155

Prestwick1_000155

Prestwick2_000155

Prestwick3_000155

Probes2_000350

QW 8184

S1150_Selleck

S-8184 Paclitaxel Injectable Emulsion

SDCCGMLS-0066823.P001

SDP-013

SMP1_000228

SMR000394086

SMR000857385

SPBio_000943

SPBio_002229

Spectrum_001536

SPECTRUM1503908

Spectrum2_000872

Spectrum3_001057

Spectrum4_001197

Spectrum5_001491

ST50306996

T 7402

T1912_SIGMA

T7191_SIGMA

T7402_SIGMA

TA1

TaxAlbin

Taxol

TAXOL

TAXOL (TN)

Taxol a

Taxol A

Taxol Konzentrat

TAXOL, 10-EPI,

Taxol, bris

Taxol.RTM. (Registered Trademark)

TXL

UNII-P88XT4IS4D

UPCMLD-DP108:001

UPCMLD-DP108:002

Vascular Wrap

weekly paclitaxel

Xorane

Yewtaxan

Etoposide

Approved

Phase 2

33419-42-0

36462

Synonyms:

(−)-etoposide

(-)-Etoposide

121471-01-0

136598-18-0

201594-04-9

33419-42-0

35317-32-9

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-b-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-β-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside

4-Demethylepipodophyllotoxin b-D-ethylideneglucoside

4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

4'-Demethylepipodophyllotoxin ethylidene-.beta.-D-glucoside

4-demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin-.beta.-D-ethylideneglucoside

4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin

51854-34-3

76576-58-4

9-((4,6-O-Ethylidine-b-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

AB00438905

AC1L1FN8

AC1L1VT3

AC1L6246

AC1NR4OG

AC1O4WGG

AC1O7M1N

AC1Q47JJ

alpha-D-Glucopyranosyl isomer etoposide

Ambap33419-42-0

Baxter brand OF etoposide

Baxter oncology brand OF etoposide

Bio1_000489

Bio1_000978

Bio1_001467

BPBio1_000673

BRD-K37798499-001-02-5

Bristol myers brand OF etoposide

Bristol myers squibb brand OF etoposide

Bristol-myers brand OF etoposide

Bristol-myers squibb brand OF etoposide

BSPBio_000611

C01576

CCRIS 2392

Celltop

CHEBI:4911

CHEBI:588795

CHEMBL44657

CID11758093

CID284997

CID3310

CID36462

CID5284558

CID6419930

CID6610299

CPD000112002

D00125

DB00773

DEMETHY-EPIPODOPHYLLOTOXIN,ETHYLIDENE GLUCOSIDE,

Demethyl epipodophyllotoxin ethylidine glucoside

Demethyl Epipodophyllotoxin Ethylidine Glucoside

Demethyl-epiodophyllotoxin ethylidene glucoside

Demethylepipodophyllotoxin-beta-D-ethylideneglucoside

E0675

E1383_SIGMA

EINECS 251-509-1

Epipodophyllotoxin VP-16213

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-.beta.-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-.beta.-D-glucopyranoside)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

Eposide

Eposin

Eposin, Vepesid, VP-16, Toposar, Etoposide

Eto gry

Eto-gry

Etomedac

ETOP

Etopol

Etopophos

Etopophos (phosphate salt)

Etopos

etoposide

Etoposide

Etoposide (JP15/USP/INN)

Etoposide (VP16)

Etoposide [USAN:INN:BAN:JAN]

Etoposide pierre fabre

Etoposide teva

Etoposide, (5a alpha)-isomer

Etoposide, (5a alpha,9 alpha)-isomer

Etoposide, (5S)-isomer

Etoposide, alpha D glucopyranosyl isomer

Etoposide, alpha-D-glucopyranosyl isomer

Etoposido

Etoposido [INN-Spanish]

Etoposido ferrer farma

Etoposidum

Etoposidum [INN-Latin]

Etosid

Exitop

Ferrer brand OF etoposide

Gry brand OF etoposide

HMS1569O13

HMS2052N05

HMS2089F14

HSDB 6517

I06-0248

KBioSS_002410

Lastet

Lemery brand OF etoposide

LS-1214

Medac brand OF etoposide

MLS000049957

MLS001074951

MLS001424283

MLS002153463

MLS002207239

MLS002222184

MolPort-003-983-431

MolPort-004-905-001

MolPort-004-955-161

NCGC00025056-02

NChemBio.2007.10-comp19

nchembio.573-comp8

nchembio873-comp2

NK 171

Novartis brand OF etoposide

NSC 141540

NSC141540

NSC-141540

Onkoposid

Onkoworks brand OF etoposide

Pharmachemie brand OF etoposide

Pierre fabre brand OF etoposide

Prasfarma brand OF etoposide

Prestwick_211

Prestwick0_000396

Prestwick1_000396

Prestwick2_000396

Prestwick3_000396

Riboposid

Ribosepharm brand OF etoposide

S1225_Selleck

SAM001246880

Sanfer brand OF etoposide

SMR000112002

SPBio_002532

ST056353

Tedec meiji brand OF etoposide

Teva brand OF etoposide

Teva, etoposide

Toposar

trans-Etoposide

UNII-6PLQ3CP4P3

Vepesid

VePesid

VePESID (TN)

Vepesid J

Vepeside

Vépéside sandoz

Vépéside-sandoz

VP 16

VP 16 (pharmaceutical)

VP 16213

VP 16-213

VP-16

VP-16-213

ZINC03830818

ZINC03938684

Zuyeyidal

Cisplatin

Approved

Phase 2

15663-27-1

84093 441203 2767

Synonyms:

(SP-4-1)-diamminedichloridoplatinum

(SP-4-1)-diamminedichloroplatinum

(SP-4-2)-diamminedichloridoplatinum

(SP-4-2)-diamminedichloroplatinum

Abiplatin

Biocisplatinum

Briplatin

CACP

Carboquone

CDDP

CHEBI:35852

CID441203

Cis Pt II

cis-[PtCl2(NH3)2]

cis-DDP

Cis-DDP

Cis-Diaminedichloroplatinum

cis-diamminedichloridoplatinum(II)

cis-Diamminedichloroplatinum

Cis-Diamminedichloroplatinum

cis-diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

Cismaplat

Cisplatin

Cisplatine

cisplatino

Cisplatino

Cisplatinum

Cisplatyl

Citoplationo

CPD0-1392

CPDC

CPDD

DB00515

DDP

DDPT

Diamminedichloroplatinum

EU-0100918

Lederplatin

nchembio773-comp1

Neoplatin

Peyrone's chloride

Peyrone's salt

Plastin

Platamine

Platiblastin

Platidiam

Platinex

Platinol

Platinol-AQ

Platinoxan

Platinum Ammine Chloride

Platinum Ammonium Chloride

Platinum Diamine Dichloride

Randa

trans-DDP

Trans-DDP

Trans-Diaminedichloroplatinum

trans-diamminedichloridoplatinum(II)

Trans-Diamminedichloroplatinum

Trans-Dichlorodiammine Platinum

Trans-Platinumdiammine Dichloride

Bleomycin

Approved, Investigational

Phase 2

11056-06-7

5360373

Synonyms:

(betaR)-N(alpha)-{[6-amino-2-((1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl)-5-methylpyrimidin-4-yl]carbonyl}-beta-{2-O-[3-O-(aminocarbonyl)-alpha-D-mannopyranosyl]-alpha-L-gulopyranosyloxy}-N-[(1R,2S,3S)-5-({(1S,2R)-1-[({2-[4-({[3-(dimethylsulfonio)propyl]amino}carbonyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}amino)carbonyl]-2-hydroxypropyl}amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl]-L-histidinamide

11056-06-7

11116-31-7

1400-95-9

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

37208-04-1

37293-16-6

37353-43-8

9041-93-4

9041-93-4 (sulfate (salt))

AC1L9UFF

AC1NSEJD

AC1NUTOQ

Almirall brand OF bleomycin sulfate

Bellon brand OF bleomycin sulfate

Bellon, bléomycine

Blanoxan

Blenoxane

Bleo

Bleo cell

Bleo-cell

BLEOcell

Bleocin

Bleogin

Bleolem

Bleomicin

Bleomicina

Bleomicina [INN-Spanish]

bleomycin

Bleomycin

Bleomycin a(2)

Bleomycin A(2)

bleomycin a2

Bleomycin a2

Bleomycin A2

Bleomycin A2 & Bleomycin B2.

Bleomycin b(2)

Bleomycin B(2)

Bleomycin b2

Bleomycin B2

Bleomycin sulfate

Bleomycin sulphate

Bleomycine

Bleomycine [INN-French]

Bléomycine bellon

Bleomycins

Bleomycinum

Bleomycinum [INN-Latin]

Bleomycinum mack

BLM

Bristol myers squibb brand OF bleomycin sulfate

Bristol-myers squibb brand OF bleomycin sulfate

Bull brand OF bleomycin sulfate

C06854

C55H85N17O21S3

C55H86N17O21S3

CCRIS 2754

Cell pharm brand OF bleomycin sulfate

CHEBI:3139

CHEMBL403664

CID456190

CID5360373

CID5460769

DB00290

EINECS 234-356-5

HSDB 3208

Lemery brand OF bleomycin sulfate

LMPK14000006

LS-44860

LS-524

Lundbeck brand OF bleomycin sulfate

Mack brand OF bleomycin sulfate

Mack, bleomycinum

N(1)-[3-(dimethylsulfonio)propyl]bleomycinamide

N1-(3-(Dimethylsulfonio)propyl)bleomycinamide

NDC 0015-3010

NSC 125066

Pingyangmyvin A2

STOCK1N-74760

Sulfate, bleomycin

UNII-13M89UEA7W

UNII-40S1VHN69B

Zhengguangmycin A2

Zhengguangmycin A2 [Chinese]

Carboplatin

Approved

Phase 2

41575-94-4

10339178 498142 38904

Synonyms:

(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum

/h1-3H2,(H,7,8)(H,9,10)

1,1-Cyclobutanedicarboxylate diammine platinum (II)

1,1-Cyclobutanedicarboxylate diammine platinum(II)

2*-1

2*1H2

41575-94-4

70903-55-8

AC-1457

AC1L8I6U

Ambap41575-94-4

azanide

Blastocarb

BSPBio_003145

C 2538

C2043

C2538_SIGMA

C6H10N2O4Pt

Carbopaltin

Carboplat

carboplatin

Carboplatin

Carboplatin (JAN/USP/INN)

Carboplatin (USAN)

Carboplatin [USAN:INN:BAN:JAN]

Carboplatine

Carboplatine [French]

Carboplatino

Carboplatino [Spanish]

Carboplatinum

Carboplatinum [Latin]

Carbosin

Carbotec

Cbdca

CBDCA

CCRIS 3404

CHEBI:31355

CHEMBL1351

CHEMBL288376

CID10339178

CID2567

CID38904

CID426756

CID498142

CID5352133

CID6398587

CID6603770

cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum

cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II)

cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)

cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(cyclobutanedicarboxylato)platinum II

Cyclobutane-1,1-dicarboxylate

cyclobutane-1,1-dicarboxylic acid

D01363

DB00958

Diammine(1,1-cyclobutanedicarboxylato)platinum (II)

Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum

diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum

Diammine-1,1-cyclobutane dicarboxylate platinum II

DivK1c_000892

EINECS 255-446-0

Ercar

EU-0100230

HMS1921J16

HMS2090M05

HMS2092B22

HMS502M14

HSDB 6957

I14-2390

IDI1_000892

InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6

IUPAC: Azane

JM 8

JM8

JM-8

KBio1_000892

KBio2_002009

KBio2_004577

KBio2_007145

KBio3_002645

KBioGR_000713

KBioSS_002009

Lopac0_000230

Lopac-C-2538

LS-117689

MolPort-003-665-501

MolPort-003-845-609

NCGC00015223-01

NCGC00093695-01

NCGC00094961-01

NCGC00094961-02

NCGC00094961-03

NCGC00162099-01

NCGC00162099-02

NCGC00167800-01

NCGC00178242-01

nchembio.573-comp10

nchembio773-comp2

nchembio873-comp3

Nealorin

Neocarbo

NINDS_000892

NSC 201345

NSC 241240

NSC201345

NSC241240

NSC-241240

Paraplatin

Paraplatin (TN)

Paraplatin, Carboplatin

Paraplatin-AQ

Platinum(+2) Cation

platinum(2+)

Platinum(II), (1, 1-cyclobutanedicar

Platinum, {diammine[1,1-cyclobut

Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)

Ribocarbo

S1215_Selleck

SPBio_000716

Spectrum_001529

SPECTRUM1502106

Spectrum2_000898

Spectrum3_001503

Spectrum4_000337

Spectrum5_001094

UNII-BG3F62OND5

Angiogenesis Inhibitors

Phase 2

Immunoglobulin G

Phase 2

Mitogens

Phase 2

Immunologic Factors

Phase 2

Immunoglobulins, Intravenous

Phase 2

Endothelial Growth Factors

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Immunoglobulins

Phase 2

Antibodies

Phase 2

Antibodies, Monoclonal

Phase 2

Hormones

Phase 2

Estrogen Antagonists

Phase 2

Estrogens

Phase 2

Hormone Antagonists

Phase 2

Estrogen Receptor Antagonists

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Albumin-Bound Paclitaxel

Phase 2

Tubulin Modulators

Phase 2

Antimitotic Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Etoposide phosphate

Phase 2

Anti-Bacterial Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Multicenter, Prospective, Randomized Trial Comparing Paclitaxel and Carboplatin or Bleomycin, Etoposide and Cisplatin in the Treatment of Ovarian Malignant Sex Cord-Stromal Tumors	Recruiting	NCT02429700	Phase 3	Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
2	A Randomized, Open Label, Phase II Trial of Bevacizumab Plus Weekly Paclitaxel Followed by Bevacizumab Monotherapy Maintenance Versus Weekly Paclitaxel Followed by Observation in Patients With Relapsed Ovarian Sex-cord Stromal Tumours	Unknown status	NCT01770301	Phase 2	Paclitaxel;Bevacizumab
3	A Phase II Trial of NCI-Supplied Agent: Bevacizumab (rhuMAB VEGF) (NSC# 704865) for Recurrent Sex Cord-Stromal Tumors of the Ovary	Completed	NCT00748657	Phase 2
4	Phase II Study of Paclitaxel for Ovarian Stromal Tumors as Second-Line Therapy	Completed	NCT00006227	Phase 2	Paclitaxel
5	An Open-label, Single Arm, Prospective, Multi-center, Tandem Two Stage Designed, Phase II Study to Evaluate the Efficacy of Fulvestrant in Women With Recurrent/Metastatic Estrogen Receptor Positive Gynecological Malignancies	Recruiting	NCT03926936	Phase 2	Fulvestrant
6	DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors	Recruiting	NCT02834013	Phase 2
7	A Randomized Phase II Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex Cord-Stromal Tumors of the Ovary	Active, not recruiting	NCT01042522	Phase 2	Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
8	DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood	Completed	NCT01572467
9	Living After a Rare Cancer of the Ovary: Chronic Fatigue, Quality of Life and Late Effects of Chemotherapy	Recruiting	NCT03418844

Search NIH Clinical Center for Sex Cord-Gonadal Stromal Tumor

Cochrane evidence based reviews: sex cord-gonadal stromal tumors

Sources

Genetic Tests for Sex Cord-Gonadal Stromal Tumor

Sources

Anatomical Context for Sex Cord-Gonadal Stromal Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Sex Cord-Gonadal Stromal Tumor:

¹⁹

Sex Cord-Derived Tissues Of The Ovary

MalaCards organs/tissues related to Sex Cord-Gonadal Stromal Tumor:

⁴⁰

Testis, Ovary, Endothelial, Pituitary, Thyroid, Adrenal Gland

Sources

Publications for Sex Cord-Gonadal Stromal Tumor

Articles related to Sex Cord-Gonadal Stromal Tumor:

(show top 50) (show all 53)

#	Title	Authors	PMID	Year
1	Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome. ⁶	Sato Y...Ogawa S	24855271	2014
2	Activating mutations of the stimulatory g protein in juvenile ovarian granulosa cell tumors: a new prognostic factor? ⁶	Kalfa N...Sultan C	16507630	2006
3	Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations. ⁶	Collins MT...Shenker A	12970318	2003
4	Cushing's syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene. ⁶	Fragoso MC...Mendonca BB	12727968	2003
5	Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. ⁶	Fragoso MC...Villares SM	9626141	1998
6	Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. ⁶	Yang I...Choi Y	8766942	1996
7	Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. ⁶	Candeliere GA...St-Arnaud R	7739708	1995
8	Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. ⁶	Schwindinger WF...Levine MA	1594625	1992
9	Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. ⁶	Weinstein LS...Spiegel AM	1944469	1991
10	GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. ⁶	Landis CA...Vallar L	2549426	1989
11	The McCune-Albright syndrome: a lethal gene surviving by mosaicism. ⁶	Happle R	3720010	1986
12	Leydig cell ovarian tumor - clinical case description and literature review. ⁶¹	Klimek M...Witek A	33100950	2020
13	Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. ⁵⁴	Zhao C...Vang R	19033865	2009
14	Calretinin: diagnostic utility in the female genital tract. ⁵⁴	Portugal R...Oliva E	19550372	2009
15	Sex cord-gonadal stromal tumor of the rete testis. ⁶¹	Sajadi KP...Brown JA	19125206	2009
16	SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. ⁵⁴	Zhao C...Vang R	18753972	2008
17	Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. ⁵⁴	Farinola MA...Vang R	17885486	2007
18	Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. ⁵⁴	Zhao C...Vang R	17721194	2007
19	CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. ⁵⁴	McCluggage WG...McBride HA	17581419	2007
20	[Immunohistochemical sex cord markers. Description and use in the differential diagnosis of ovarian tumors]. ⁵⁴	Kommoss F...Schmidt D	17429635	2007
21	Incompletely differentiated (unclassified) sex cord/gonadal stromal tumor of the testis with a "pure" spindle cell component: report of a case with diagnostic and histogenetic considerations. ⁶¹	Magro G...Greco P	17850986	2007
22	The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors. ⁵⁴	Cathro HP...Stoler MH	15754297	2005
23	The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis. ⁵⁴	Emerson RE...Ulbright TM	16512598	2005
24	Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. ⁵⁴	Baker PM...Oliva E	15626916	2005
25	High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia. ⁵⁴	Korner M...Reubi JC	15623622	2004
26	An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. ⁵⁴	McCluggage WG...Young RH	15381902	2004
27	Inhibins as biomarkers for reproductive cancers. ⁵⁴	Robertson DM...McNeilage J	15319824	2004
28	[Ovarian tumors with endocrine function]. ⁵⁴	Guo LN...Zhou Q	15256111	2004
29	Neuropeptide Y receptor expression in human primary ovarian neoplasms. ⁵⁴	Korner M...Reubi JC	14631382	2004
30	Sclerosing stromal tumors of the ovary: a clinicopathologic, immunohistochemical and cytogenetic analysis of three cases. ⁵⁴	Kostopoulou E...Leontsini M	15032299	2004
31	Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin. ⁵⁴	Deavers MT...Silva EG	12808064	2003
32	Ovarian steroid cell tumors: an immunohistochemical study including a comparison of calretinin with inhibin. ⁵⁴	Deavers MT...Silva EG	12649671	2003
33	Inhibin immunohistochemical staining: a practical approach for the surgical pathologist in the diagnoses of ovarian sex cord-stromal tumors. ⁵⁴	Zheng W...Parkash V	12502966	2003
34	Expression of calretinin in human ovary, testis, and ovarian sex cord-stromal tumors. ⁵⁴	Cao QJ...Li M	11603218	2001
35	Value of inhibin staining in gynecological pathology. ⁵⁴	McCluggage WG	11192074	2001
36	No evidence of somatic activating mutations on gonadotropin receptor genes in sex cord stromal tumors. ⁵⁴	Giacaglia LR...Latronico AC	11056247	2000
37	Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors. ⁵⁴	Choi YL...Ahn G	10747314	2000
38	Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. ⁵⁴	Devouassoux-Shisheboran M...Tavassoli FA	10414506	1999
39	Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. ⁵⁴	Iczkowski KA...Cheville JC	9720507	1998
40	CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis. ⁵⁴	Gordon MD...Beckstead J	9720506	1998
41	Müllerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. ⁵⁴	Matias-Guiu X...Prat J	9712426	1998
42	Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. ⁵⁴	Guerrieri C...Boeryd B	9656124	1998
43	Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. ⁵⁴	McCluggage WG...Biggart JD	9591732	1998
44	Inhibin and epithelial membrane antigen immunohistochemistry assist in the diagnosis of sex cord-stromal tumors and provide clues to the histogenesis of hypercalcemic small cell carcinomas. ⁵⁴	Riopel MA...Sherman ME	9475192	1998
45	An enormous testicular sex cord/gonadal stromal tumor. ⁶¹	Miller MI...Hensle TW	8811574	1996
46	Immunohistochemical localization of Ad4-binding protein with correlation to steroidogenic enzyme expression in cycling human ovaries and sex cord stromal tumors. ⁵⁴	Takayama K...Yajima A	7673429	1995
47	Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor. ⁵⁴	Shikone T...Hsueh AJ	7997239	1994
48	Histogenetic consideration of ovarian sex cord-stromal tumors analyzed by expression pattern of cytokeratins, vimentin, and laminin. Correlation studies with human gonads. ⁵⁴	Park SH...Kim I	7527534	1994
49	Response of metastasized sex cord gonadal stromal tumor of the testis to cisplatin-based chemotherapy. ⁶¹	Dieckmann KP...Loy V	7510344	1994
50	Immunohistochemical phenotype of ovarian granulosa cell tumors: absence of epithelial membrane antigen has diagnostic value. ⁵⁴	Costa MJ...Cohen C	8314261	1994

Sources

Genes for Sex Cord-Gonadal Stromal Tumor

Genes related to Sex Cord-Gonadal Stromal Tumor (1 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	GNAS	GNAS Complex Locus	Protein Coding	405.97	Pathogenic ⁶ DISEASES inferred ¹⁵	1944469 7739708 2549426 (more) 8766942 12970318 9626141 16507630 24855271
2	CALB2	Calbindin 2	Protein Coding	18.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11603218 15256111 19550372 (more) 15626916 15754297 19033865 10414506 17581419 12808064 12649671 17429635 16512598
3	INHA	Inhibin Subunit Alpha	Protein Coding	17.25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11192074 10747314 15256111 (more) 15381902 7997239 15319824 17581419 12502966 9712426 9475192 17429635
4	WT1	WT1 Transcription Factor	Protein Coding	14.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8504409 19033865 17721194
5	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	14.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19033865 7673429 18753972
6	KRT7	Keratin 7	Protein Coding	14.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9656124 17429635
7	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	12.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9475192 9591732 9656124
8	VIM	Vimentin	Protein Coding	11.25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7527534 9591732 9720506
9	INHBA	Inhibin Subunit Beta A	Protein Coding	11.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	10747314
10	PGR	Progesterone Receptor	Protein Coding	11.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17885486 9720507 15032299
11	FSHR	Follicle Stimulating Hormone Receptor	Protein Coding	11.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11056247
12	ALPP	Alkaline Phosphatase, Placental	Protein Coding	9.54	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9591732
13	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	9.37	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9591732
14	NKX2-1	NK2 Homeobox 1	Protein Coding	8.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15381902
15	FOXL2	Forkhead Box L2	Protein Coding	7.95	DISEASES inferred ¹⁵
16	DICER1	Dicer 1, Ribonuclease III	Protein Coding	7.81	DISEASES inferred ¹⁵
17	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	7.34	DISEASES inferred ¹⁵
18	AFP	Alpha Fetoprotein	Protein Coding	7.26	DISEASES inferred ¹⁵
19	MLANA	Melan-A	Protein Coding	7.01	DISEASES inferred ¹⁵
20	PDE11A	Phosphodiesterase 11A	Protein Coding	6.69	DISEASES inferred ¹⁵
21	POMC	Proopiomelanocortin	Protein Coding	6.52	DISEASES inferred ¹⁵

Sources

Variations for Sex Cord-Gonadal Stromal Tumor

ClinVar genetic disease variations for Sex Cord-Gonadal Stromal Tumor:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	GNAS	NM_000516.6(GNAS):c.601C>T (p.Arg201Cys)	SNV	Pathogenic	15933	rs11554273	20:57484420-57484420	20:58909365-58909365
2	GNAS	NM_000516.6(GNAS):c.602G>A (p.Arg201His)	SNV	Pathogenic	15934	rs121913495	20:57484421-57484421	20:58909366-58909366

Cosmic variations for Sex Cord-Gonadal Stromal Tumor:

⁹ (show top 50) (show all 96)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM99815457	SPEN	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.9338G>A	p.R3113Q	1:15935578-15935578	6
2	COSM91859752	KRAS	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.35G>T	p.G12V	12:25245350-25245350	6
3	COSM134614978	KRAS	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.35G>T	p.G12V	12:25245350-25245350	6
4	COSM134990158	KRAS	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.35G>T	p.G12V	12:25245350-25245350	6
5	COSM87804055	KRAS	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.35G>T	p.G12V	12:25245350-25245350	6
6	COSM150806731	KDR	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.1372T>G	p.W458G	4:55107777-55107777	6
7	COSM87033244	KDR	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.1372T>G	p.W458G	4:55107777-55107777	6
8	COSM89404125	FOXL2	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.402C>G	p.C134W	3:138946321-138946321	6
9	COSM92463160	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5428G>T	p.D1810Y	14:95091302-95091302	6
10	COSM128908209	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5113G>A	p.E1705K	14:95094139-95094139	6
11	COSM99956165	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5439G>C	p.E1813D	14:95091291-95091291	6
12	COSM92465015	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5437G>C	p.E1813Q	14:95091293-95091293	6
13	COSM127764798	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5125G>A	p.D1709N	14:95094127-95094127	6
14	COSM92462429	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5113G>A	p.E1705K	14:95094139-95094139	6
15	COSM128908230	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5439G>C	p.E1813D	14:95091291-95091291	6
16	COSM131473380	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5113G>A	p.E1705K	14:95094139-95094139	6
17	COSM127764998	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5428G>A	p.D1810N	14:95091302-95091302	6
18	COSM134823880	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.1807G>A	p.E603K	14:95094139-95094139	6
19	COSM134823943	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2132A>C	p.E711A	14:95091292-95091292	6
20	COSM99956457	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5125G>A	p.D1709N	14:95094127-95094127	6
21	COSM128911758	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5437G>C	p.E1813Q	14:95091293-95091293	6
22	COSM131473612	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5125G>A	p.D1709N	14:95094127-95094127	6
23	COSM134825030	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2131G>C	p.E711Q	14:95091293-95091293	6
24	COSM99956147	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5113G>A	p.E1705K	14:95094139-95094139	6
25	COSM131477892	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5127T>A	p.D1709E	14:95094125-95094125	6
26	COSM134825443	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.1821T>A	p.D607E	14:95094125-95094125	6
27	COSM92462640	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5125G>A	p.D1709N	14:95094127-95094127	6
28	COSM134824018	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.1819G>A	p.D607N	14:95094127-95094127	6
29	COSM127764510	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5113G>A	p.E1705K	14:95094139-95094139	6
30	COSM131473400	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5365-182G>C	p.?	14:95091291-95091291	6
31	COSM128908220	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5438A>G	p.E1813G	14:95091292-95091292	6
32	COSM134824008	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2122G>C	p.D708H	14:95091302-95091302	6
33	COSM127767697	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5437G>C	p.E1813Q	14:95091293-95091293	6
34	COSM127764521	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5438A>G	p.E1813G	14:95091292-95091292	6
35	COSM99958835	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5437G>C	p.E1813Q	14:95091293-95091293	6
36	COSM131476604	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5365-184G>C	p.?	14:95091293-95091293	6
37	COSM128908575	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5125G>A	p.D1709N	14:95094127-95094127	6
38	COSM134823886	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2132A>G	p.E711G	14:95091292-95091292	6
39	COSM99957014	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5428G>T	p.D1810Y	14:95091302-95091302	6
40	COSM92462443	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5439G>C	p.E1813D	14:95091291-95091291	6
41	COSM134824218	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2122G>T	p.D708Y	14:95091302-95091302	6
42	COSM92470802	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5126A>T	p.D1709V	14:95094126-95094126	6
43	COSM127764780	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5437G>A	p.E1813K	14:95091293-95091293	6
44	COSM128908518	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5437G>A	p.E1813K	14:95091293-95091293	6
45	COSM92462437	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5438A>G	p.E1813G	14:95091292-95091292	6
46	COSM127764790	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5428G>C	p.D1810H	14:95091302-95091302	6
47	COSM99956156	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5438A>G	p.E1813G	14:95091292-95091292	6
48	COSM131473389	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.5365-183A>G	p.?	14:95091292-95091292	6
49	COSM134823927	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2133G>C	p.E711D	14:95091291-95091291	6
50	COSM134824162	DICER1	ovary,NS,sex cord-stromal tumour,Sertoli-Leydig cell tumour	c.2133G>T	p.E711D	14:95091291-95091291	6

Sources

Expression for Sex Cord-Gonadal Stromal Tumor

Search GEO for disease gene expression data for Sex Cord-Gonadal Stromal Tumor.

Sources

Pathways for Sex Cord-Gonadal Stromal Tumor

Pathways related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.48	WT1 VIM INHBA ALPP AFP
2	Transcription_CREM signaling in testis ²³	10.69	PRKAR1A GNAS FSHR
3	Ovarian Infertility Genes ¹	10.43	PGR NR5A1 INHA FSHR

Sources

GO Terms for Sex Cord-Gonadal Stromal Tumor

Cellular components related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inhibin A complex	GO:0043512	8.62	INHBA INHA

Biological processes related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.93	WT1 VIM NR5A1 NKX2-1 INHBA
2	gonad development	GO:0008406	9.55	WT1 FSHR
3	cellular response to follicle-stimulating hormone stimulus	GO:0071372	9.52	INHBA FSHR
4	positive regulation of male gonad development	GO:2000020	9.51	WT1 NR5A1
5	sex determination	GO:0007530	9.49	WT1 NR5A1
6	negative regulation of macrophage differentiation	GO:0045650	9.48	INHBA INHA
7	hemoglobin biosynthetic process	GO:0042541	9.46	INHBA INHA
8	SMAD protein signal transduction	GO:0060395	9.46	VIM INHBA INHA AFP
9	ovulation from ovarian follicle	GO:0001542	9.43	PGR AFP
10	positive regulation of follicle-stimulating hormone secretion	GO:0046881	9.4	INHBA INHA
11	negative regulation of B cell differentiation	GO:0045578	9.37	INHBA INHA
12	negative regulation of female gonad development	GO:2000195	9.32	WT1 NR5A1
13	negative regulation of follicle-stimulating hormone secretion	GO:0046882	9.26	INHBA INHA
14	ovarian follicle development	GO:0001541	9.26	INHBA INHA FSHR FOXL2
15	male gonad development	GO:0008584	9.02	WT1 NR5A1 INHBA INHA FSHR

Molecular functions related to Sex Cord-Gonadal Stromal Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.13	WT1 VIM PRKAR1A PGR PDE11A NR5A1
2	sequence-specific DNA binding	GO:0043565	9.35	WT1 PGR NR5A1 NKX2-1 FOXL2
3	inhibin binding	GO:0034711	8.62	INHBA INHA

Sources

Sources for Sex Cord-Gonadal Stromal Tumor

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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⁹ Cosmic

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²⁴ GeneHancer via GeneCards

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²⁷ GEO DataSets

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³¹ HPO

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³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

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³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MedlinePlus Genetics

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia