Aliases & Classifications for Sexual Disorder

MalaCards integrated aliases for Sexual Disorder:

Name: Sexual Disorder 12 15
Sexual Dysfunction 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060043
UMLS 74 C0549622

Summaries for Sexual Disorder

Disease Ontology : 12 A disease of mental health that involves the impairment in normal sexual functioning.

MalaCards based summary : Sexual Disorder, also known as sexual dysfunction, is related to hypoactive sexual desire disorder and impotence, and has symptoms including increased libido An important gene associated with Sexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Response to elevated platelet cytosolic Ca2+. The drugs Fenofibrate and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and bone, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Sexual Disorder

Diseases related to Sexual Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 hypoactive sexual desire disorder 33.6 HTR1A SHBG
2 impotence 31.7 ALDH7A1 KCNMA1 KLK3 NOS1 NOS3 PDE5A
3 prostatic hyperplasia, benign 30.7 ADRA1A KLK3 PDE5A SHBG
4 priapism 30.2 ADRA1A NOS3 PDE5A
5 androgenic alopecia 30.2 KLK3 PRL SHBG
6 disease of mental health 30.0 HTR1A OXT PDE5A
7 psychotic disorder 30.0 HTR1A NOS1 PRL
8 premenstrual tension 29.8 OXT PRL SHBG
9 gynecomastia 29.8 KLK3 PRL SHBG
10 social phobia 29.7 HTR1A PRL
11 obsessive-compulsive disorder 29.7 HTR1A OXT PRL
12 attention deficit-hyperactivity disorder 28.8 ADRA1A ADRA2A ADRA2C HTR1A OXT
13 persistent genital arousal disorder 11.3
14 cauda equina syndrome 11.3
15 adverse events of 5-alpha-reductase inhibitors 11.3
16 toxic encephalopathy 11.1
17 tarlov cysts 11.1
18 inhibited male orgasm 11.0
19 adrenomyeloneuropathy 11.0
20 sacral nerve root cysts 11.0
21 paraphilia disorder 10.8
22 depression 10.7
23 multiple sclerosis 10.6
24 schizophrenia 10.5
25 infertility 10.5
26 anxiety 10.4
27 diabetes mellitus 10.4
28 epilepsy 10.4
29 breast cancer 10.4
30 hypogonadism 10.3
31 hypogonadotropism 10.3
32 vasculogenic impotence 10.3 ALDH7A1 NOS3 PDE5A
33 aging 10.3
34 major depressive disorder 10.3
35 psychologic vaginismus 10.3
36 psychologic dyspareunia 10.3
37 jejunoileitis 10.3 ALDH7A1 NOS1 NOS3
38 spinal cord injury 10.3
39 prostatitis 10.3
40 tetrahydrobiopterin deficiency 10.3 NOS1 NOS3 PRL
41 estrogen excess 10.3 PRL SHBG
42 inflammatory bowel disease 10.3
43 pelvic varices 10.2 PRL SHBG
44 varicocele 10.2 NOS3 PRL SHBG
45 acquired metabolic disease 10.2 NOS3 PRL SHBG
46 prostatic adenoma 10.2
47 arthritis 10.2
48 retinitis pigmentosa 19 10.2 ALDH7A1 KCNMA1
49 cervical cancer 10.2
50 postmenopausal atrophic vaginitis 10.2 OXT SHBG

Graphical network of the top 20 diseases related to Sexual Disorder:



Diseases related to Sexual Disorder

Symptoms & Phenotypes for Sexual Disorder

UMLS symptoms related to Sexual Disorder:


increased libido

MGI Mouse Phenotypes related to Sexual Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C HTR1A
2 cardiovascular system MP:0005385 9.65 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C HTR1A
3 nervous system MP:0003631 9.32 ADRA1D ADRA2A ADRA2C HTR1A KCNMA1 NOS1

Drugs & Therapeutics for Sexual Disorder

Drugs for Sexual Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 533)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fenofibrate Approved Phase 4 49562-28-9 3339
2
Angiotensin II Approved, Investigational Phase 4,Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198
3
Metoprolol Approved, Investigational Phase 4,Not Applicable 37350-58-6, 51384-51-1 4171
4
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
5
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
6
Saw palmetto Approved, Experimental, Investigational Phase 4
7
Aripiprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 129722-12-9 60795
8
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
9
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 62-31-7, 51-61-6 681
10
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68-04-2
11
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 5949-44-0
12
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 315-37-7 9416
13
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-18-4 6010
14
Testosterone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-22-0, 481-30-1 10204 6013
15
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 171596-29-5 110635
16
Nebivolol Approved, Investigational Phase 4,Not Applicable 152520-56-4, 99200-09-6, 118457-14-0 71301
17
Bupivacaine Approved, Investigational Phase 4,Phase 1 38396-39-3, 2180-92-9 2474
18
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
19
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
20
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 1 57-63-6 5991
21
Drospirenone Approved Phase 4 67392-87-4 68873
22
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
23
tannic acid Approved Phase 4,Phase 2,Phase 3,Not Applicable 1401-55-4
24
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
25
Udenafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 268203-93-6 6918523
26
Alfuzosin Approved, Investigational Phase 4,Phase 3,Not Applicable 81403-80-7 2092
27
Tamoxifen Approved Phase 4,Phase 2 10540-29-1 2733526
28
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-84-3 187
29
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
30
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 745-65-3 5280723 149351
31
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
32
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
33
Zinc Approved, Investigational Phase 4 7440-66-6 32051
34
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
35
Bupropion Approved Phase 4,Phase 2,Phase 3,Phase 1 34841-39-9, 34911-55-2 444
36
Vortioxetine Approved, Investigational Phase 4,Phase 3 508233-74-7 9966051
37
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
38
Allantoin Approved Phase 4 97-59-6 204
39
Curcumin Approved, Experimental, Investigational Phase 4,Not Applicable 458-37-7 969516
40
Yohimbine Approved, Investigational, Vet_approved Phase 4,Phase 1 146-48-5 8969
41
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
42
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 6473866 445643 439492
43
Valsartan Approved, Investigational Phase 4,Phase 3 137862-53-4 60846
44
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
45
Tibolone Approved, Investigational Phase 4,Phase 3 5630-53-5
46
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
47 Lynestrenol Approved, Investigational Phase 4 52-76-6
48
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
49
Estrone Approved Phase 4,Phase 1 53-16-7 5870
50
Sertraline Approved Phase 4,Phase 2 79617-96-2 68617

Interventional clinical trials:

(show top 50) (show all 1010)
# Name Status NCT ID Phase Drugs
1 Treatment of Hyperlipidemia and Sexual Dysfunction Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
2 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
3 Clinical Study to Assess the Influence of a Saw Palmetto Preparation in Patients With Benign Prostatic Hyperplasia (BPH) and Sexual Dysfunctions Unknown status NCT01021267 Phase 4 Saw palmetto berry extract
4 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
5 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
6 Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males Unknown status NCT00313898 Phase 4 sildenafil (viagra)
7 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
8 Testosterone Patch's Effects on the Cardiovascular System and Libido Unknown status NCT01208038 Phase 4 Intrinsa Transdermal testosterone patch
9 Effect of Tadalafil on Erectile Dysfunction Treatment and QOL Improvement Effect (by SF-12) in Andropause Patients With Erectile Dysfunction Unknown status NCT02943356 Phase 4 Tadalafil
10 Nebivolol Effects on Endothelial Function and Erectile Function Unknown status NCT01885988 Phase 4 Nebivolol;Sugar Pill
11 Nerve Grafting With an Allograft During Radical Prostatectomy - Extended Follow-up in a Prospective Randomized Trial Unknown status NCT01770340 Phase 4
12 Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment Unknown status NCT01364701 Phase 4 Sildenafil 100 mg;Tadalafil 20 mg;Combination half of maximal dose for sildenafil & tadalafil
13 Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate Unknown status NCT00555087 Phase 4 Testosterone Undecanoate and/or PDE-5
14 Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i Unknown status NCT00498680 Phase 4 Sildenafil, Vardenafil;Sildenafil;Vardenafil;Sildenafil & Vardenafil
15 Trigger Point Injections and Pelvic Rehabilitation for the Treatment of Pelvic Floor Myalgia and Sexual Pain Unknown status NCT02022722 Phase 4 Trigger Point Injections Triamcinolone Acetonide, Bupivacaine Hydrochloride
16 Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis Unknown status NCT02344823 Phase 4 Vardenafil;Placebo intake once daily
17 Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction Unknown status NCT03169582 Phase 4 Avanafil;Sildenafil
18 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
19 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
20 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
21 Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo Completed NCT00334048 Phase 4 Ropinirole (Requip)
22 Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction Completed NCT00174850 Phase 4 Gaitril
23 Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women Completed NCT00375297 Phase 4 sildenafil
24 Statin Lowering Testosterone and Sexual Function Completed NCT02612714 Phase 4 Rosuvastatin
25 Levitra (Vardenafil, BAY38-9456) Partner Satisfaction Study II Completed NCT00377793 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
26 Daily Tadalafil on Body Fat and Lean Mass Completed NCT02554045 Phase 4 Tadalafil;Placebo
27 Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder Completed NCT01971099 Phase 4 tribulus terrestris
28 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris
29 SAMBA: Sexuality And Management of Benign Prostatic Hyperplasia With Alfuzosin Completed NCT00486785 Phase 4 Alfuzosin
30 Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients Completed NCT01468519 Phase 4 Insulin;Insulin
31 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
32 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
33 Sexual Functioning Study With Antidepressants Completed NCT00316160 Phase 4 Bupropion Hydrochloride Extended-release;Extended-release Venlafaxine
34 Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men Completed NCT01642576 Phase 4
35 Effects of Diet-induced Weight Loss in Obese Men Completed NCT01554865 Phase 4
36 Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554735 Phase 4
37 Wellbutrin XL Effects on SSRIs Induced Changes Completed NCT00456820 Phase 4 Wellbutrin XL
38 Effect of Vortioxetine, Paroxetine, and Placebo on Sexual Functioning in Healthy Volunteers Completed NCT02932904 Phase 4 Vortioxetine;Paroxetine;Placebo
39 Effects of Tribulus Terrestris on Sexual Function in Post-menopausal Women Completed NCT01407445 Phase 4 Placebo;Tribulus terrestris
40 Vardenafil and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
41 The Efficacy and Safety of New Herbal Formula (KBMSI-2) in the Treatment of Erectile Dysfunction Completed NCT02413099 Phase 4 KBMSI-2
42 A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction Completed NCT02224846 Phase 4 Tadalafil
43 Study Evaluating the Effects of Avanafil on Semen Parameters Completed NCT01768676 Phase 4 avanafil;Placebo
44 Research Evaluating a PDE5 Inhibitor for Erectile Dysfunction Completed NCT01698684 Phase 4 Placebo;Avanafil 100 mg;Avanafil 200 mg
45 A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China Completed NCT01352507 Phase 4 Tadalafil;Sildenafil
46 Efficacy and Safety of Lodenafil Carbonate in the Treatment of Erectile Dysfunction in Patients With Diabetes. Completed NCT01180283 Phase 4 lodenafil carbonate
47 Satisfaction, Confidence and Naturalness in Men With Psychogenic Erectile Dysfunction (ED) Completed NCT01153204 Phase 4 Sildenafil citrate
48 A Study in Erectile Dysfunction Completed NCT01130532 Phase 4 Tadalafil;Placebo
49 A Study in Patients With Erectile Dysfunction Completed NCT01122264 Phase 4 Tadalafil;Sildenafil Citrate
50 A Study of Tadalafil After Radical Prostatectomy Completed NCT01026818 Phase 4 Tadalafil;Placebo

Search NIH Clinical Center for Sexual Disorder

Genetic Tests for Sexual Disorder

Anatomical Context for Sexual Disorder

MalaCards organs/tissues related to Sexual Disorder:

42
Prostate, Spinal Cord, Bone, Brain, Heart, Testes, Kidney

Publications for Sexual Disorder

Articles related to Sexual Disorder:

(show top 50) (show all 2948)
# Title Authors Year
1
Association Between Alcohol Use and Female Sexual Dysfunction From the Data Registry on Experiences of Aging, Menopause, and Sexuality (DREAMS). ( 30674443 )
2019
2
Finasteride for androgenetic alopecia is not associated with sexual dysfunction: A survey-based, single-center, controlled study. ( 30835851 )
2019
3
Sexual dysfunction and phobic anxiety in breast cancer survivors. ( 30225895 )
2019
4
High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study. ( 30173156 )
2019
5
Sexual Dysfunction in Breast Cancer Survivors: Is it Surgical Modality or Adjuvant Therapy? ( 31094713 )
2019
6
Association between epilepsy and risk of sexual dysfunction: A meta-analysis. ( 30639977 )
2019
7
Nonalcoholic Fatty Liver Disease, Male Sexual Dysfunction, and Infertility: Common Links, Common Problems. ( 30898592 )
2019
8
Long-Term Follow-Up of Sexual Dysfunction in Women Following Allogeneic Hematopoietic Stem Cell Transplantation. ( 30132158 )
2019
9
Male Sexual Dysfunction Among Egyptian Patients with Chronic Hepatitis C Virus Infection Before and After Direct-Acting Antiviral Drugs. ( 30846113 )
2019
10
Sexual dysfunction and hyperprolactinemia in schizophrenia before and after six weeks of D2/3 receptor blockade - An exploratory study. ( 30780063 )
2019
11
Investigating the basis of sexual dysfunction during late-onset hypogonadism. ( 30984376 )
2019
12
Sexual dysfunction and Fertility Problems in Men with Inflammatory Bowel Disease. ( 30929327 )
2019
13
Prevalence of sexual dysfunction in women with systemic lupus erythematosus and its related factors. ( 30858627 )
2019
14
Prevalence and Psychopathological Determinants of Sexual Dysfunction and Related Distress in Women With and Without Multiple Sclerosis. ( 31010780 )
2019
15
Lower urinary tract symptoms and sexual dysfunction in men with multiple sclerosis. ( 30892415 )
2019
16
Female Sexual Dysfunction Among Greek Women With Multiple Sclerosis: Correlations With Organic and Psychological Factors. ( 30638831 )
2019
17
Sexual dysfunction in women with human papilloma virus infection in the Turkish population. ( 30856026 )
2019
18
Sexual Dysfunction in Women With Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis. ( 30833151 )
2019
19
Is polycystic ovary syndrome associated with risk of female sexual dysfunction? A systematic review and meta-analysis. ( 30926178 )
2019
20
Predictors of Sexual Dysfunction in Veterans with Post-Traumatic Stress Disorder. ( 30934864 )
2019
21
Sexual dysfunction in patients with schizophrenia and schizoaffective disorder and its association with adherence to antipsychotic medication. ( 30862199 )
2019
22
Predictive Factors of Male Sexual Dysfunction after Traumatic Spinal Cord Injury. ( 30973511 )
2019
23
Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis. ( 30945005 )
2019
24
Application of Sex Aids in Men With Sexual Dysfunction: A Review. ( 31029536 )
2019
25
Sexual Dysfunction and Bother Due to Erectile Dysfunction in the Healthy Elderly Male Population: Prevalence from a Systematic Review. ( 30878347 )
2019
26
Platelet-Rich Plasma Therapy for Male Sexual Dysfunction: Myth or Reality? ( 30898594 )
2019
27
Reply to Comment on "Inflammatory Bowel Diseases Were Associated With Risk of Sexual Dysfunction in Both Sexes: A Meta-analysis" by Li Y and Liu X. ( 30851039 )
2019
28
Inflammatory Bowel Diseases Were Associated With Risk of Sexual Dysfunction in Both Sexes: A Meta-analysis. ( 30476074 )
2019
29
Sexual dysfunction is a more common problem in young women with type 1 diabetes than in healthy. ( 31007158 )
2019
30
Sexual Dysfunction in Women Treated for Type 1 Diabetes and the Impact of Coexisting Thyroid Disease. ( 30954495 )
2019
31
Psychological burden prediction based on demographic variables among infertile men with sexual dysfunction. ( 30460932 )
2019
32
A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women. ( 30488972 )
2019
33
The relationship between injury mechanism and sexual dysfunction in surgically treated pelvic fractures. ( 30617402 )
2019
34
Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study. ( 30640584 )
2019
35
Re: Association between Comorbidities and Female Sexual Dysfunction: . ( 30653027 )
2019
36
Investigation of prostate resected weight on postoperative sexual dysfunction following transurethral resection of prostate surgery: a population-based study. ( 30666121 )
2019
37
Efficacy and safety of a non-hormonal intravaginal moisturizer for the treatment of vaginal dryness in postmenopausal women with sexual dysfunction. ( 30677618 )
2019
38
Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male Rats. ( 30678046 )
2019
39
Resolution of Female Sexual Dysfunction (FSD) Among the Obese Multiethnic Malaysian Women Now a Reality with Bariatric Surgery: a Prospective Pilot Study in Malaysia. ( 30706310 )
2019
40
Incidence and severity of sexual dysfunction among women with breast cancer: a meta-analysis based on female sexual function index. ( 30712099 )
2019
41
Prevalence and possible predictors of sexual dysfunction and self-reported needs related to the sexual life of advanced cancer patients. ( 30724646 )
2019
42
Re: Transcutaneous Electrical Nerve Stimulation to Improve Female Sexual Dysfunction Symptoms: . ( 30759643 )
2019
43
Approach to sexual dysfunction in women with cancer. ( 30765487 )
2019
44
Parkinson's Disease Is Associated with Risk of Sexual Dysfunction in Men but Not in Women: A Systematic Review and Meta-Analysis. ( 30773498 )
2019
45
Sexual Dysfunction among Men in Rural Tamil Nadu: Nature, Prevalence, Clinical Features, and Explanatory Models. ( 30783313 )
2019
46
A Real-World Study on Antidepressant-Associated Sexual Dysfunction in 2144 Outpatients: The SALSEX I Study. ( 30790204 )
2019
47
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. ( 30798136 )
2019
48
The ABC of Sexual Dysfunction conference. ( 30804222 )
2019
49
Prospective Study on Sexual Dysfunction in Male Chinese Liver Transplant Recipients. ( 30836839 )
2019
50
When sex meets age: Family physicians' perspectives about sexual dysfunction among older men and women: A qualitative study from Israel. ( 30848972 )
2019

Variations for Sexual Disorder

Expression for Sexual Disorder

Search GEO for disease gene expression data for Sexual Disorder.

Pathways for Sexual Disorder

Pathways related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C HTR1A
2
Show member pathways
13.08 ADRA2A ADRA2B ADRA2C KCNMA1 NOS1 NOS3
3
Show member pathways
12.39 ADRA2A ADRA2B ADRA2C RHOA
4
Show member pathways
12.32 ADRA1A ADRA1D NOS1 NOS3 OXT
5
Show member pathways
12.07 KCNMA1 NOS1 NOS3 PDE5A
6
Show member pathways
12.06 ADRA1A ADRA1D NOS1 NOS3
7
Show member pathways
11.98 ADRA1A ADRA1D KCNMA1 NOS1
8
Show member pathways
11.98 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C KCNMA1
9
Show member pathways
11.97 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C NOS3
10
Show member pathways
11.83 ADRA1A ADRA1D RHOA
11
Show member pathways
11.73 ADRA2A ADRA2B ADRA2C
12
Show member pathways
11.67 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C HTR1A
13
Show member pathways
11.44 ALDH7A1 NOS1 NOS3
14
Show member pathways
11.25 KCNMA1 NOS1 NOS3 PDE5A
15 11.23 ADRA1A ADRA2A ADRA2B RHOA
16 10.96 NOS1 NOS3
17 10.72 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C
18 10.66 NOS1 NOS3 PDE5A
19 10.43 NOS1 NOS3

GO Terms for Sexual Disorder

Cellular components related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.96 KLK3 OXT
2 caveola GO:0005901 8.92 ADRA1A KCNMA1 NOS1 NOS3

Biological processes related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.91 ADRA1A ADRA1D ADRA2B ADRA2C
2 positive regulation of MAPK cascade GO:0043410 9.86 ADRA1A ADRA2A ADRA2B ADRA2C
3 platelet activation GO:0030168 9.82 ADRA2A ADRA2B ADRA2C
4 positive regulation of neuron differentiation GO:0045666 9.81 ADRA2B ADRA2C RHOA
5 female pregnancy GO:0007565 9.78 ADRA2B ADRA2C OXT PRL
6 response to hormone GO:0009725 9.75 ADRA1A NOS1 NOS3
7 activation of protein kinase B activity GO:0032148 9.72 ADRA2A ADRA2B ADRA2C
8 positive regulation of vasoconstriction GO:0045907 9.71 ADRA1A ADRA2C RHOA
9 negative regulation of blood pressure GO:0045776 9.7 NOS1 NOS3 OXT
10 positive regulation of blood pressure GO:0045777 9.67 ADRA2B OXT
11 regulation of cardiac muscle contraction GO:0055117 9.66 ADRA1A NOS1
12 positive regulation of smooth muscle contraction GO:0045987 9.66 ADRA1A RHOA
13 vasodilation GO:0042311 9.65 NOS1 NOS3
14 regulation of sodium ion transport GO:0002028 9.65 NOS1 NOS3
15 nitric oxide mediated signal transduction GO:0007263 9.65 NOS1 NOS3
16 nitric oxide biosynthetic process GO:0006809 9.64 NOS1 NOS3
17 regulation of smooth muscle contraction GO:0006940 9.63 ADRA2A ADRA2B ADRA2C
18 negative regulation of potassium ion transport GO:0043267 9.62 NOS1 NOS3
19 positive regulation of guanylate cyclase activity GO:0031284 9.62 NOS1 NOS3
20 negative regulation of calcium ion transport GO:0051926 9.61 ADRA2A NOS1 NOS3
21 arginine catabolic process GO:0006527 9.6 NOS1 NOS3
22 negative regulation of hydrolase activity GO:0051346 9.59 NOS1 NOS3
23 positive regulation of uterine smooth muscle contraction GO:0070474 9.58 ADRA2B OXT
24 negative regulation of norepinephrine secretion GO:0010700 9.58 ADRA2A ADRA2B ADRA2C
25 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.57 NOS3 RHOA
26 regulation of vasoconstriction GO:0019229 9.56 ADRA1A ADRA2A ADRA2B ADRA2C
27 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.55 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C
28 negative regulation of epinephrine secretion GO:0032811 9.54 ADRA2A ADRA2B ADRA2C
29 micturition GO:0060073 9.51 ADRA1A KCNMA1
30 receptor transactivation GO:0035624 9.5 ADRA2A ADRA2B ADRA2C
31 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.35 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C
32 multicellular organismal response to stress GO:0033555 9.3 NOS1
33 adrenergic receptor signaling pathway GO:0071875 9.02 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C
34 signal transduction GO:0007165 10.23 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C HTR1A
35 G protein-coupled receptor signaling pathway GO:0007186 10.1 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C HTR1A

Molecular functions related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 FMN binding GO:0010181 9.48 NOS1 NOS3
2 arginine binding GO:0034618 9.46 NOS1 NOS3
3 NADPH-hemoprotein reductase activity GO:0003958 9.43 NOS1 NOS3
4 cadmium ion binding GO:0046870 9.4 NOS1 NOS3
5 tetrahydrobiopterin binding GO:0034617 9.37 NOS1 NOS3
6 epinephrine binding GO:0051379 9.33 ADRA2A ADRA2B ADRA2C
7 alpha1-adrenergic receptor activity GO:0004937 9.32 ADRA1A ADRA1D
8 nitric-oxide synthase activity GO:0004517 9.26 NOS1 NOS3
9 alpha2-adrenergic receptor activity GO:0004938 9.13 ADRA2A ADRA2B ADRA2C
10 adrenergic receptor activity GO:0004935 9.02 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C

Sources for Sexual Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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