Aliases & Classifications for Sexual Disorder

MalaCards integrated aliases for Sexual Disorder:

Name: Sexual Disorder 12 15
Sexual Dysfunction 17 70


External Ids:

Disease Ontology 12 DOID:0060043
UMLS 70 C0549622

Summaries for Sexual Disorder

Disease Ontology : 12 A disease of mental health that involves the impairment in normal sexual functioning.

MalaCards based summary : Sexual Disorder, also known as sexual dysfunction, is related to apnea, obstructive sleep and inhibited male orgasm, and has symptoms including increased libido An important gene associated with Sexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Prolactin Signaling Pathway and Shigellosis. The drugs Fenofibrate and Saw palmetto have been mentioned in the context of this disorder. Affiliated tissues include prostate, breast and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Sexual dysfunction is difficulty experienced by an individual or a couple during any stage of a normal... more...

Related Diseases for Sexual Disorder

Diseases related to Sexual Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 500)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 32.0 NOS3 INS HTR2A ACE
2 inhibited male orgasm 31.9 SLC6A4 OXT HTR2C HTR1A
3 paraphilia disorder 31.8 SLC6A4 OXT
4 premature ejaculation 31.8 SLC6A4 PDE5A OXT HTR2C HTR1A
5 hypogonadism 31.5 SHBG PRL PDE5A INS
6 prostatic hyperplasia, benign 31.5 PDE5A KLK3
7 prostatic adenoma 31.5 SHBG PRL KLK3
8 prostatitis 31.4 PRL PDE5A KLK3
9 hyperprolactinemia 31.2 SHBG PRL INS HTR2C HTR2A
10 depression 31.1 SLC6A4 PRL NOS1 HTR2C HTR2A HTR1A
11 psychosexual disorder 31.1 SLC6A4 SHBG PRL PDE5A OXT HTR2C
12 mental depression 31.1 SLC6A4 OXT INS HTR2C HTR2A HTR1A
13 acute stress disorder 31.0 SLC6A4 OXT HTR1A
14 amenorrhea 31.0 SHBG PRL INS
15 major depressive disorder 31.0 SLC6A4 PRL OXT HTR2C HTR2A HTR1A
16 lipid metabolism disorder 31.0 SHBG PDE5A INS ACE
17 gynecomastia 30.9 SHBG PRL KLK3
18 acute cystitis 30.9 KLK3 INS ACE
19 generalized anxiety disorder 30.9 SLC6A4 HTR2A HTR1A
20 alcohol use disorder 30.7 SLC6A4 HTR2C HTR2A HTR1A
21 mood disorder 30.7 SLC6A4 HTR2C HTR2A HTR1A ACE
22 androgenic alopecia 30.7 SHBG PRL KLK3 INS
23 urethral stricture 30.7 PDE5A KLK3
24 congestive heart failure 30.7 PDE5A NOS3 INS ACE
25 diabetes mellitus 30.7 SHBG PRL PDE5A NOS3 NOS1 KLK3
26 alcohol dependence 30.7 SLC6A4 HTR2C HTR2A HTR1A ACE
27 hypopituitarism 30.7 SHBG PRL INS
28 inhibited female orgasm 30.7 SHBG PRL PDE5A OXT HTR2A HTR1A
29 hyperandrogenism 30.6 SHBG PRL INS
30 sleep apnea 30.6 SLC6A4 NOS3 INS HTR2C HTR2A ACE
31 substance abuse 30.6 SLC6A4 PRL INS HTR2A HTR1A ACE
32 postpartum depression 30.6 SLC6A4 PRL OXT HTR1A
33 anxiety 30.6 SLC6A4 PRL OXT INS HTR2C HTR2A
34 eating disorder 30.6 SLC6A4 HTR2C HTR2A
35 vascular disease 30.6 SLC6A4 NOS3 NOS1 INS HTR2A ACE
36 irritable bowel syndrome 30.6 SLC6A4 HTR2A HTR1A
37 hyperthyroidism 30.5 SHBG PRL INS
38 panic disorder 30.5 SLC6A4 PRL HTR2C HTR2A HTR1A ACE
39 chronic fatigue syndrome 30.5 SLC6A4 INS HTR2A HTR1A
40 schizophrenia 30.5 SLC6A4 PRL OXT NOS1 INS HTR2C
41 schizoaffective disorder 30.5 SLC6A4 PRL INS HTR2A HTR1A
42 cardiovascular system disease 30.5 SHBG PDE5A NOS3 INS ACE
43 personality disorder 30.5 SLC6A4 PRL HTR2C HTR2A HTR1A
44 anovulation 30.4 SHBG PRL INS
45 psychotic disorder 30.4 SLC6A4 PRL OXT NOS1 HTR2C HTR2A
46 type 2 diabetes mellitus 30.4 SHBG PRL PDE5A OXT NOS3 NOS1
47 glucose intolerance 30.4 SHBG PRL NOS3 INS ACE
48 obsessive-compulsive disorder 30.3 SLC6A4 PRL OXT HTR2C HTR2A HTR1A
49 pulmonary disease, chronic obstructive 30.3 SLC6A4 PDE5A PDE4A INS ACE
50 arteries, anomalies of 30.3 NOS3 MIR141 INS ACE

Graphical network of the top 20 diseases related to Sexual Disorder:

Diseases related to Sexual Disorder

Symptoms & Phenotypes for Sexual Disorder

UMLS symptoms related to Sexual Disorder:

increased libido

MGI Mouse Phenotypes related to Sexual Disorder:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 ACE ALDH7A1 HTR1A HTR2A HTR2C INS
2 homeostasis/metabolism MP:0005376 9.97 ACE ALDH7A1 HTR1A HTR2C INS NOS1
3 adipose tissue MP:0005375 9.87 ACE HTR1A HTR2C INS NOS1 NOS3
4 nervous system MP:0003631 9.83 ACE ALDH7A1 HTR1A HTR2C INS NOS1
5 normal MP:0002873 9.32 ALDH7A1 INS KLK3 NOS1 NOS3 PDE5A

Drugs & Therapeutics for Sexual Disorder

Drugs for Sexual Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Fenofibrate Approved Phase 4 49562-28-9 3339
Saw palmetto Approved, Experimental, Investigational Phase 4
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
Sodium citrate Approved, Investigational Phase 4 68-04-2
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Norepinephrine Approved Phase 4 51-41-2 439260
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
Estrone Approved Phase 4 53-16-7 5870
Sertraline Approved Phase 4 79617-96-2 68617
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
15 Vasodilator Agents Phase 4
16 Phosphodiesterase Inhibitors Phase 4
17 Phosphodiesterase 5 Inhibitors Phase 4
18 Saw palmetto extract Phase 4
19 Tribulus Phase 4
20 Rosuvastatin Calcium Phase 4 147098-20-2
21 Antimetabolites Phase 4
22 Anticholesteremic Agents Phase 4
23 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
24 Hypolipidemic Agents Phase 4
25 Lipid Regulating Agents Phase 4
26 Calcium, Dietary Phase 4
27 Venlafaxine Hydrochloride Phase 4
28 Dopamine Uptake Inhibitors Phase 4
29 Cytochrome P-450 Enzyme Inhibitors Phase 4
30 Citrate Phase 4
31 Sildenafil Citrate Phase 4 171599-83-0
32 Antiparkinson Agents Phase 4
33 Vardenafil Dihydrochloride Phase 4
34 Anti-Arrhythmia Agents Phase 4
35 Anesthetics Phase 4
36 Sodium Channel Blockers Phase 4
37 Pharmaceutical Solutions Phase 4
38 Diuretics, Potassium Sparing Phase 4
39 Anesthetics, Local Phase 4
40 Hormone Antagonists Phase 4
41 Hormones Phase 4
42 Estrogens Phase 4
43 Neurotransmitter Agents Phase 4
44 Psychotropic Drugs Phase 4
45 Serotonin Uptake Inhibitors Phase 4
46 Antidepressive Agents Phase 4
47 Dopamine Agents Phase 4
48 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
49 Dopamine Antagonists Phase 4
50 Dopamine agonists Phase 4

Interventional clinical trials:

(show top 50) (show all 230)
# Name Status NCT ID Phase Drugs
1 Effect of Fenofibrate and Rosuvastatin on Sexual Dysfunction in Hyperlipidemic Patients. A Randomized Trial Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
2 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
3 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
4 Clinical Pilot Trial on the Influence of a Saw Palmetto Berry Preparation on Sexual Functions in Patients With Benign Prostatic Hyperplasia Unknown status NCT01021267 Phase 4 Saw palmetto berry extract
5 The Effect of Treatment for ED on Quality of Life and Satisfaction in a Group of Patients Without Prior Complaints of Sexual Dysfunction Unknown status NCT00313898 Phase 4 sildenafil (viagra)
6 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris
7 Statin Therapy is Associated With Low Testosterone and Sexual Function in Men With Type 2 Diabetes Completed NCT02612714 Phase 4 Rosuvastatin
8 A Twelve-week, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group, Active Controlled, Escalating Dose Study to Compare the Effects on Sexual Functioning of Bupropion Hydrochloride Extended-release (WELLBUTRIN XL, 150-450 mg/Day) and Extended-release Venlafaxine (EFFEXOR XR, 75-225 mg/Day) in Subjects With Major Depressive Disorder Completed NCT00316160 Phase 4 Bupropion Hydrochloride Extended-release;Extended-release Venlafaxine
9 Randomized Double Blind Placebo Controlled Study of Sildenafil for Treatment of Serotonergic Reuptake Inhibitor Associated Sexual Dysfunction in Women With Major Depression Treated to Remission Completed NCT00375297 Phase 4 sildenafil
10 A 14 Week Open-Label Study to Evaluate the Tolerability of Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction in Generalized Anxiety Disorder Patients Completed NCT00174850 Phase 4 Gaitril
11 Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men Completed NCT01642576 Phase 4
12 The Effects of Lifestyle-modification Induced Weight Loss on Metabolic and Inflammatory Profile, Endothelial, Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554735 Phase 4
13 The Effects of Diet-induced Weight Loss on Metabolic and Inflammatory Profile, Endothelial, Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554865 Phase 4
14 Treatment of Sexual Dysfunction Secondary to Antidepressant Pharmacotherapy: A Double-blind Comparison of Requip (Ropinirole) vs. Placebo in Patients Taking SSRI Antidepressants Completed NCT00334048 Phase 4 Ropinirole (Requip)
15 A Randomized, Double Blind, Parallel Group Study of Vardenafil Flexible Dose Versus Placebo in Males With Erectile Dysfunction and Their Female Partners Sexual Quality of Life. PARTNER II Completed NCT00377793 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
16 Sexual Dysfunction in Gynecologic Oncology Patients Recruiting NCT03801031 Phase 4 Lidocaine Topical;Placebo
17 An Open-label Study to Determine the Effect of Switching to Aripiprazole Once Monthly for Subjects With Schizophrenia Experiencing Worsening Sexual Dysfunction With Invega Sustenna or Risperdal Consta Terminated NCT02472652 Phase 4 Abilify Maintena
18 Ospemifene Versus Conjugated Estrogens in the Treatment of Postmenopausal Sexual Dysfunction Terminated NCT03018106 Phase 4 Ospemifene;Vaginal conjugated estrogens
19 A Randomized, Double-Blind, Active Controlled Clinical Trial of Switching to Vilazodone for Antidepressant-Associated Sexual Dysfunction Terminated NCT01856127 Phase 4 Vilazodone;Sertraline
20 Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction Terminated NCT00398632 Phase 4 Duloxetine
21 The Role of 5-Alpha Reductase in Mediating Testosterone Actions Unknown status NCT00070733 Phase 3 testosterone enanthate;duastride
22 THE INFLUENCE OF COGNITIVE BEHAVIORAL THERAPY IN SEXUAL DYSFUNCTION FEMALE: Randomized Clinical Trial Unknown status NCT02613546 Phase 2, Phase 3
23 MAPS (Men After Prostate Surgery) : Conservative Treatment for Men With Urinary Incontinence After Prostate Surgery; Multicentre Randomised Controlled Trial of Pelvic Floor Muscle Training and Biofeedback [MAPS] Completed NCT00632138 Phase 3
24 A Randomized, Double-blind, Placebo-controlled Phase III Trial to Evaluate the Effectiveness of a Phosphodiesterase 5 Inhibitor, Tadalafil, in Prevention of Erectile Dysfunction in Patients Treated With Radiotherapy for Prostate Cancer Completed NCT00931528 Phase 3 Tadalafil
25 Vaginal DHEA for Vaginal Symptoms: A Phase III Randomized, Double Blind, Placebo- Controlled Trial Completed NCT01376349 Phase 3 prasterone
26 Randomized Double-Blind Placebo Controlled Study of Testosterone in the Adjuvant Treatment of Postmenopausal Women With Aromatase Inhibitor Induced Arthralgias Completed NCT01573442 Phase 3 testosterone
27 Impact of Lactate-containing Vaginal Lubricant on Sexual Dysfunction in Young Breast Cancer Survivors: Prospective Randomized Controlled Trial Completed NCT00981305 Phase 3 Lactate-containing vaginal lubricant;Placebo vaginal lubricant
28 Pilocarpine for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study Completed NCT00343382 Phase 3 pilocarpine hydrochloride
29 A Placebo-Controlled, Double-Blind, Randomized, Parallel-Group Study of the Efficacy and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3 Dapoxetine
30 A Placebo-Controlled, Double-Blind, Randomized, Parallel Study of the Withdrawal Effects of Chronic Daily and As-Needed Dosing With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3 Dapoxetine
31 A Placebo-Controlled, Double-Blind, Randomized, Parallel-Group Study Of The Efficacy And Safety Of Dapoxetine In The Treatment Of Subjects With Premature Ejaculation Completed NCT00229073 Phase 3 dapoxetine
32 The Use of Low Dose Testosterone To Enhance Libido In Female Cancer Survivors: A Phase III Randomized, Placebo-Controlled, Double-Blind Crossover Study Completed NCT00075855 Phase 3 therapeutic testosterone
33 A Multicenter, Double-Blind, Randomized, Placebo Controlled Comparison of the Effects on Sexual Functioning of Extended-Release Bupropion Hydrochloride (300-450mg) and Escitalopram (10-20mg) in Outpatients With Moderate to Severe Major Depression Over an Eight-Week Treatment Period Completed NCT00051259 Phase 3 Extended-Release Bupropion Hydrochloride
34 A Placebo-Controlled, Double-Blind, Randomized, Parallel Study Of The Efficacy And Safety Of Dapoxetine HCl In The Treatment Of Rapid Ejaculation Completed NCT00211107 Phase 3 Dapoxetine
35 A Placebo-Controlled, Double-blind, Randomized, Parallel Study of the Efficacy and Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT00211094 Phase 3 Dapoxetine
36 A Double-Blind, Placebo Controlled Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females Completed NCT00568126 Phase 3 Maca Root;Placebo
37 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3 Dapoxetine
38 A Multicenter, Randomized, Double-Blind, Double Dummy Trial to Compare the Effects Tibolone and Transdermal Continuous Combined Estradiol/Norethisterone on Sexual Desire and Arousal in Postmenopausal Women With Sexual Dysfunction Completed NCT00413764 Phase 3 tibolone;estradiol-norethisterone
39 A Randomized, Placebo-Controlled, Double-Blind, Parallel Design Trial of the Efficacy and Safety of Zestra(TM) in Women With Mixed Desire/Interest/Arousal/Orgasm Disorders Completed NCT00118495 Phase 3 Non-prescription Zestra(TM): patented formulation
40 A Randomized Study of an Internet-based Cognitive Behavioral Therapy Program for Sexuality and Intimacy Problems in Women Treated for Breast Cancer. Completed NCT02091765 Phase 3
41 Intracavernosal Injection of Botulinum Toxin Type A in the Treatment of Erectile Dysfunction (Phase 2 Study) Completed NCT03102762 Phase 2, Phase 3 Botulinum Toxin Type A;Normal saline
42 A Randomized, Double-blind, Double-dummy, Multicenter Parallel Group Study to Compare the Tolerability and Efficacy of Once Daily Vardenafil Versus Vardenafil PRN Versus Placebo in Men Immediately After Nerve-sparing Prostatectomy for Improving Erectile Function Completed NCT00492635 Phase 3 Levitra (Vardenafil, BAY38-9456);Levitra (Vardenafil, BAY38-9456);Placebo
43 A Twenty-Eight Week, Open-Label, Safety Study of Flibanserin 50 Mgs to 100 Mgs Daily in Premenopausal European Women With HSDD Completed NCT00601367 Phase 3 flibanserin flexible dose
44 24-wk Efficacy and Safety of Flibanserin vs Pbo in Naturally Postmenopausal Women in United States Completed NCT00996372 Phase 3 flibanserin;placebo
45 A Twenty-four Week, Randomized, Double-blind, Placebo Controlled, Safety and Efficacy Trial of Flibanserin (100 Milligrams) Administered Orally Once Daily in Premenopausal Women With Hypoactive Sexual Desire Disorder in the United States Completed NCT00996164 Phase 3 Flibanserin;Placebo
46 A Twenty-Four Week, Randomized, Double-Blind, Placebo Controlled, Safety and Efficacy Trial of Flibanserin 50 Milligrams Daily and 100 Milligrams Daily in Premenopausal European Women With Hypoactive Sexual Desire Disorder Completed NCT00491829 Phase 3 50 mg qhs;100 mg;placebo
47 12-month Sustained Efficacy of Flibanserin v Placebo n Younger Women With HSDD in NA Completed NCT00277914 Phase 3 Flibanserin
48 Best Tolerability: 50mg Twice Daily Versus 100 mg in the Evening Versus 25 mg Twice Daily Versus Placebo in Younger Women in North America Completed NCT00360555 Phase 3 flibanserin;flibanserin 50mg;flibanserin 100mg;placebo
49 A Twenty Four Week, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Trial of Flibanserin 50mg Every Evening and Flibanserin 100mg Every Evening in Women With Hypoactive Sexual Desire Disorder in North America Completed NCT00360529 Phase 3 flibanserin
50 6-mo. Min Eff Dose of Flibanserin: 25 v 50 mg Bid v 50 mg hs v Pbo in Younger Women in NA Completed NCT00360243 Phase 3 flibanserin;flibanserin;flibanserin;placebo

Search NIH Clinical Center for Sexual Disorder

Genetic Tests for Sexual Disorder

Anatomical Context for Sexual Disorder

MalaCards organs/tissues related to Sexual Disorder:

Prostate, Breast, Spinal Cord, Kidney, Brain, Pituitary, Heart

Publications for Sexual Disorder

Articles related to Sexual Disorder:

(show top 50) (show all 10592)
# Title Authors PMID Year
Pubertal immune challenge suppresses the hypothalamic-pituitary-gonadal axis in male and female mice. 61
33571552 2021
Effect of increased prolactin and psychosocial stress on erectile function. 61
33595132 2021
Late-onset hypogonadism: Clinical evidence, biological aspects and evolutionary considerations. 61
33610812 2021
Sexual and functional long-term outcomes following advanced pelvic cancer and reconstruction using vertical rectus abdominis myocutaneous and gluteal myocutaneous flap. 61
33008672 2021
The Oncology and Sexuality, Intimacy, and Survivorship Program Model: An Integrated, Multi-disciplinary Model of Sexual Health Care within Oncology. 61
31797198 2021
CO2 laser and the genitourinary syndrome of menopause: a randomized sham-controlled trial. 61
33089713 2021
Systematization for female genital anatomic variations. 61
32783342 2021
Oxidative stress caused by a dysregulated Wnt/β-catenin signalling pathway is involved in abnormal placenta formation in pregnant mice with chronic fatigue syndrome. 61
33054899 2021
Complications and functional outcomes after ileo-anal pouch excision-a systematic review of 14 retrospective observational studies. 61
33471205 2021
Systematic assessment of autonomic symptoms in restless legs syndrome. 61
33548567 2021
Polyvictimization and the Associations Between Poor Self-Perceived Health, Dissatisfaction With Life, and Sexual Dysfunction Among Women in Estonia. 61
29884111 2021
Violence and sexual dysfunction among infertile Egyptian women. 61
33530133 2021
Pelvic floor disorders and sexuality in women with ovarian cancer: A systematic review. 61
33516528 2021
The management of sexual dysfunction resulting from radiotherapy and androgen deprivation therapy to treat prostate cancer: A comparison of uro-oncology practice according to disease stage. 61
33260255 2021
Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy. 61
32106695 2021
It Takes a Village: The First 100 Patients Seen in a Multidisciplinary Pelvic Floor Clinic. 61
32371720 2021
Prospective assessment of urinary and bowel symptoms, and sexual function between laparoscopic assisted vaginal radical trachelectomy and radical hysterectomy. 61
33649018 2021
Clinical utility of radiofrequency energy for female genitourinary dysfunction: past, present, and future. 61
33661319 2021
What happens to female sexual function during pregnancy? 61
33485263 2021
Use of Testosterone in Postmenopausal Women. 61
33518180 2021
Hands-on versus hands-off techniques for the prevention of perineal trauma during vaginal delivery: a systematic review and meta-analysis of randomized controlled trials. 61
31092083 2021
Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. 61
33801678 2021
Effect of vitamins on sexual function: A systematic review. 61
33779240 2021
Effects of liver transplantation on sexual function and quality of life. 61
33688768 2021
Circumcision in childhood and male sexual function: a blessing or a curse? 61
32994555 2021
Labia Minora Surgery in the Adolescent Population: A Cross-Sectional Satisfaction Study. 61
33536146 2021
Diagnostic Methods for Vaginal Stenosis and Compliance to Vaginal Dilator Use: A Systematic Review. 61
33526400 2021
Erectile dysfunction pattern in patients with end stage renal disease on regular dialysis. 61
33783280 2021
Update on the Medical and Surgical Management of Urethral Condyloma. 61
33752995 2021
Priapism following a juvenile Russell's viper bite: An unusual case report. 61
33764978 2021
Functional recovery following resection of large Tarlov cyst malformation: a multicentre longitudinal cohort study. 61
33761006 2021
Quality of life and sexual function after a pregnancy complicated by placenta accreta spectrum. 61
33763885 2021
Recent advances in pharmacological interventions of chronic prostatitis/chronic pelvic pain syndrome. 61
33749554 2021
Perceived partner responsiveness is associated with sexual well-being in couples with genito-pelvic pain. 61
33734756 2021
A systematic review of the efficacy of surgical intervention in the management of symptomatic Tarlov cysts: a meta-analysis. 61
33754918 2021
Hypertension and erectile dysfunction: The role of endovascular therapy in Asia. 61
33314715 2021
Health-related quality of life in left ventricular assist device-supported patients. 61
33773095 2021
Navigating Women's Low Desire: Sexual Growth and Destiny Beliefs and Couples' Well-Being. 61
33656409 2021
Sexual Function and Sexual Quality of Life in Premenopausal Women with Controlled Type 1 and 2 Diabetes-Preliminary Study. 61
33806371 2021
A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis. 61
33675219 2021
Disordered Eating and Body Dissatisfaction Associated with Sexual Concerns in Undergraduate Women. 61
33730967 2021
The relationship between premature ejaculation and the timing of pre-adult circumcision. 61
33709439 2021
Buried penis in adults as a complication of circumcision: Surgical management and long-term outcomes. 61
33244793 2021
Sexual Dysfunctions in Women: Are Androgens at Fault? 61
33518181 2021
The impact of medications and medical comorbidities on sexual function in people with epilepsy. 61
33711710 2021
Bibliotherapy for Sexual Dysfunctions: A Systematic Review and Meta-Analysis. 61
33547017 2021
The Impact of Psychosis on Sexual Functioning: A Systematic Review. 61
33504468 2021
A randomized controlled study of vaginal fractional CO2 laser therapy for female sexual dysfunction. 61
33723687 2021
Sexual dysfunction in men and women with diabetes: a mirror of their complications? 61
33687898 2021
Sexual Dysfunction: A Neglected and Overlooked Issue in Adult GH Deficiency: The Management of AGHD Study. 61
33604495 2021

Variations for Sexual Disorder

Expression for Sexual Disorder

Search GEO for disease gene expression data for Sexual Disorder.

Pathways for Sexual Disorder

GO Terms for Sexual Disorder

Cellular components related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.95 SEPTIN8 SEPTIN6 RHOA PDE4A NOS1 HTR2A
2 cell junction GO:0030054 9.91 SLC6A4 SEPTIN8 SEPTIN3 RHOA NOS1 HTR2A
3 synapse GO:0045202 9.87 SLC6A4 SEPTIN8 SEPTIN3 NOS1 HTR2C HTR2A
4 presynapse GO:0098793 9.65 SLC6A4 SEPTIN8 SEPTIN6 SEPTIN3 HTR2A
5 G protein-coupled serotonin receptor complex GO:0098666 9.37 HTR2C HTR2A
6 cell division site GO:0032153 9.33 SEPTIN8 SEPTIN6 SEPTIN3
7 septin complex GO:0031105 9.13 SEPTIN8 SEPTIN6 SEPTIN3
8 septin ring GO:0005940 8.8 SEPTIN8 SEPTIN6 SEPTIN3

Biological processes related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.07 RHOA PDE4A OXT INS HTR2C HTR2A
2 positive regulation of cell proliferation GO:0008284 9.98 PRL MIR141 INS HTR2A HTR1A
3 response to drug GO:0042493 9.91 SLC6A4 RHOA HTR2C HTR2A
4 memory GO:0007613 9.74 SLC6A4 OXT HTR2A
5 cellular protein localization GO:0034613 9.72 SEPTIN8 SEPTIN6 SEPTIN3
6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.69 HTR2C HTR2A HTR1A
7 nitric oxide biosynthetic process GO:0006809 9.6 NOS3 NOS1
8 neurotransmitter biosynthetic process GO:0042136 9.59 SLC6A4 NOS1
9 sleep GO:0030431 9.58 OXT HTR2A
10 positive regulation of guanylate cyclase activity GO:0031284 9.56 NOS3 NOS1
11 negative regulation of potassium ion transport GO:0043267 9.54 NOS1 HTR2A
12 serotonin receptor signaling pathway GO:0007210 9.49 HTR2A HTR1A
13 arginine catabolic process GO:0006527 9.48 NOS3 NOS1
14 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.46 RHOA NOS3
15 sperm ejaculation GO:0042713 9.43 SLC6A4 OXT
16 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.43 HTR2C HTR2A HTR1A
17 regulation of neurological system process GO:0031644 9.4 NOS3 HTR2C
18 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.37 HTR2C HTR2A
19 negative regulation of blood pressure GO:0045776 9.33 OXT NOS3 NOS1
20 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.32 HTR2C HTR2A
21 cytoskeleton-dependent cytokinesis GO:0061640 9.13 SEPTIN8 SEPTIN6 SEPTIN3
22 behavior GO:0007610 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.49 SLC6A4 SHBG SEPTIN8 SEPTIN6 SEPTIN3 RHOA
2 molecular adaptor activity GO:0060090 9.67 SEPTIN8 SEPTIN6 SEPTIN3
3 neurotransmitter receptor activity GO:0030594 9.65 HTR2C HTR2A HTR1A
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.54 NOS3 NOS1
5 FMN binding GO:0010181 9.52 NOS3 NOS1
6 arginine binding GO:0034618 9.46 NOS3 NOS1
7 NADPH-hemoprotein reductase activity GO:0003958 9.43 NOS3 NOS1
8 cadmium ion binding GO:0046870 9.4 NOS3 NOS1
9 tetrahydrobiopterin binding GO:0034617 9.37 NOS3 NOS1
10 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR2C HTR2A HTR1A
11 nitric-oxide synthase activity GO:0004517 9.32 NOS3 NOS1
12 Gq/11-coupled serotonin receptor activity GO:0001587 9.26 HTR2C HTR2A
13 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
14 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Sexual Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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