Aliases & Classifications for Sexual Disorder

MalaCards integrated aliases for Sexual Disorder:

Name: Sexual Disorder 12 15
Sexual Dysfunction 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060043
UMLS 73 C0549622

Summaries for Sexual Disorder

Disease Ontology : 12 A disease of mental health that involves the impairment in normal sexual functioning.

MalaCards based summary : Sexual Disorder, also known as sexual dysfunction, is related to gynecomastia and premature ejaculation, and has symptoms including increased libido An important gene associated with Sexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Vascular smooth muscle contraction and Prolactin Signaling Pathway. The drugs Fenofibrate and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and testes, and related phenotypes are cardiovascular system and nervous system

Related Diseases for Sexual Disorder

Diseases related to Sexual Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 29.7 KLK3 PRL SHBG
2 premature ejaculation 29.6 HTR1A PDE5A SLC6A4
3 social phobia 29.6 HTR1A PRL SLC6A4
4 jejunoileitis 10.2 ALDH7A1 NOS1 NOS3
5 prostatic hyperplasia, benign 10.2 KLK3 PDE5A SHBG
6 tetrahydrobiopterin deficiency 10.2 NOS1 NOS3 PRL
7 hypoactive sexual desire disorder 10.2 HTR1A SHBG
8 arteritic anterior ischemic optic neuropathy 10.2 ACE NOS3 PDE5A
9 androgenic alopecia 10.2 KLK3 PRL SHBG
10 persistent fetal circulation syndrome 10.2 EDN1 NOS3 PDE5A
11 varicocele 10.1 NOS3 PRL SHBG
12 aortic coarctation 10.1 ACE EDN1 NOS3
13 hypertension, diastolic 10.1 ACE KCNMA1
14 depression 10.1 HTR1A NOS1 SLC6A4
15 renal artery disease 10.1 ACE NOS3
16 angina pectoris 10.1 ACE EDN1 NOS3
17 acute mountain sickness 10.1 ACE EDN1 NOS3
18 intermittent explosive disorder 10.1 HTR1A PRL SLC6A4
19 pulmonary hypertension, primary, 1 10.1 EDN1 PDE5A SLC6A4
20 postmenopausal atrophic vaginitis 10.1 OXT SHBG
21 limb ischemia 10.1 ACE EDN1 NOS3
22 migraine without aura 10.1 HTR1A PRL SLC6A4
23 personality disorder 10.1 HTR1A PRL SLC6A4
24 pulmonary edema 10.1 ACE EDN1 NOS3
25 premenstrual tension 10.1 OXT PRL SHBG
26 acquired metabolic disease 10.1 ACE NOS3 PRL SHBG
27 sleep apnea 10.0 ACE EDN1 NOS3
28 mitral valve disease 10.0 ACE NOS3 SLC6A4
29 ischemic optic neuropathy 10.0 ACE EDN1 NOS3 PDE5A
30 nonarteritic anterior ischemic optic neuropathy 10.0 ACE EDN1 NOS3 PDE5A
31 arteries, anomalies of 10.0 ACE EDN1 NOS3
32 pedophilia 10.0 OXT PRL
33 renovascular hypertension 10.0 ACE EDN1 NOS1 NOS3
34 migraine with aura 10.0 ACE NOS3 SLC6A4
35 urinary system disease 10.0 ACE EDN1 KLK3
36 psychotic disorder 10.0 HTR1A NOS1 PRL SLC6A4
37 female reproductive system disease 10.0 OXT PRL SHBG
38 coronary artery anomaly 10.0 ACE EDN1 NOS3
39 ischemia 10.0 ACE EDN1 NOS1 NOS3
40 postpartum depression 10.0 OXT PRL SLC6A4
41 serotonin syndrome 10.0 HTR1A OXT SLC6A4
42 reproductive system disease 10.0 KLK3 OXT PRL SHBG
43 mental depression 10.0 HTR1A OXT SLC6A4
44 vasculogenic impotence 10.0 ACE ALDH7A1 NOS3 PDE4A PDE5A
45 psychosexual disorder 10.0 ALDH7A1 HTR1A PDE5A SHBG SLC6A4
46 oligohydramnios 9.9 ACE EDN1 OXT
47 disease of mental health 9.9 HTR1A OXT PDE5A SLC6A4
48 obsessive-compulsive disorder 9.9 HTR1A OXT PRL SLC6A4
49 bipolar disorder 9.9 HTR1A NOS1 PRL SHBG SLC6A4
50 major depressive disorder 9.9 HTR1A OXT PRL SLC6A4

Graphical network of the top 20 diseases related to Sexual Disorder:



Diseases related to Sexual Disorder

Symptoms & Phenotypes for Sexual Disorder

UMLS symptoms related to Sexual Disorder:


increased libido

MGI Mouse Phenotypes related to Sexual Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ACE EDN1 HTR1A KCNMA1 NOS1 NOS3
2 nervous system MP:0003631 9.77 EDN1 HTR1A KCNMA1 NOS1 NOS3 OXT
3 normal MP:0002873 9.23 ALDH7A1 EDN1 NOS1 NOS3 RHOA SEPT3

Drugs & Therapeutics for Sexual Disorder

Drugs for Sexual Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 513)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fenofibrate Approved Phase 4 49562-28-9 3339
2
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
3
Metoprolol Approved, Investigational Phase 4,Not Applicable 37350-58-6, 51384-51-1 4171
4
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
5
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
6
Saw palmetto Approved, Experimental, Investigational Phase 4
7
Aripiprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 129722-12-9 60795
8
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
9
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
10
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 5949-44-0
11
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-22-0 6013
12
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 315-37-7 9416
13
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-18-4 6010
14
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 171596-29-5 110635
15
Nebivolol Approved, Investigational Phase 4,Not Applicable 99200-09-6, 152520-56-4, 118457-14-0 71301
16
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
17
Bupivacaine Approved, Investigational Phase 4,Phase 1 2180-92-9, 38396-39-3 2474
18
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
19
Drospirenone Approved Phase 4 67392-87-4 68873
20 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
21
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
22
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 1 57-63-6 5991
23
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
24 tannic acid Approved Phase 4,Phase 2,Phase 3,Not Applicable
25
Alfuzosin Approved, Investigational Phase 4,Phase 3,Not Applicable 81403-80-7 2092
26
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
27
Tamoxifen Approved Phase 4,Phase 2 10540-29-1 2733526
28
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
29
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 745-65-3 149351 5280723
30
Ropinirole Approved, Investigational Phase 4 91374-21-9, 91374-20-8 497540 5095
31
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
32
Zinc Approved, Investigational Phase 4 7440-66-6
33
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
34
Bupropion Approved Phase 4,Phase 2,Phase 3,Phase 1 34841-39-9, 34911-55-2 444
35
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
36
Vortioxetine Approved, Investigational Phase 4,Phase 3 508233-74-7 9966051
37
Curcumin Approved, Experimental, Investigational Phase 4,Not Applicable 458-37-7 969516
38
Allantoin Approved Phase 4 97-59-6 204
39
Yohimbine Approved, Investigational, Vet_approved Phase 4,Phase 1 146-48-5 8969
40
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
41
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
42
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
43
Tibolone Approved, Investigational Phase 4,Phase 3 5630-53-5
44
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
45 Lynestrenol Approved, Investigational Phase 4 52-76-6
46
Estrone Approved Phase 4,Phase 1 53-16-7 5870
47
Sertraline Approved Phase 4,Phase 2 79617-96-2 68617
48
Rosiglitazone Approved, Investigational Phase 4,Phase 1 122320-73-4 77999
49
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
50
Petrolatum Approved, Investigational Phase 4 8009-03-8

Interventional clinical trials:

(show top 50) (show all 963)
# Name Status NCT ID Phase Drugs
1 Treatment of Hyperlipidemia and Sexual Dysfunction Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
2 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
3 Clinical Study to Assess the Influence of a Saw Palmetto Preparation in Patients With Benign Prostatic Hyperplasia (BPH) and Sexual Dysfunctions Unknown status NCT01021267 Phase 4 Saw palmetto berry extract
4 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
5 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
6 Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males Unknown status NCT00313898 Phase 4 sildenafil (viagra)
7 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
8 Testosterone Patch's Effects on the Cardiovascular System and Libido Unknown status NCT01208038 Phase 4 Intrinsa Transdermal testosterone patch
9 Effect of Tadalafil on Erectile Dysfunction Treatment and QOL Improvement Effect (by SF-12) in Andropause Patients With Erectile Dysfunction Unknown status NCT02943356 Phase 4 Tadalafil
10 Nebivolol Effects on Endothelial Function and Erectile Function Unknown status NCT01885988 Phase 4 Nebivolol;Sugar Pill
11 Nerve Grafting With an Allograft During Radical Prostatectomy - Extended Follow-up in a Prospective Randomized Trial Unknown status NCT01770340 Phase 4
12 Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment Unknown status NCT01364701 Phase 4 Sildenafil 100 mg;Tadalafil 20 mg;Combination half of maximal dose for sildenafil & tadalafil
13 Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate Unknown status NCT00555087 Phase 4 Testosterone Undecanoate and/or PDE-5
14 Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i Unknown status NCT00498680 Phase 4 Sildenafil, Vardenafil;Sildenafil;Vardenafil;Sildenafil & Vardenafil
15 Trigger Point Injections and Pelvic Rehabilitation for the Treatment of Pelvic Floor Myalgia and Sexual Pain Unknown status NCT02022722 Phase 4 Trigger Point Injections Triamcinolone Acetonide, Bupivacaine Hydrochloride
16 Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis Unknown status NCT02344823 Phase 4 Vardenafil;Placebo intake once daily
17 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
18 Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer Unknown status NCT00906269 Phase 4 Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
19 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
20 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
21 Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo Completed NCT00334048 Phase 4 Ropinirole (Requip)
22 Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction Completed NCT00174850 Phase 4 Gaitril
23 Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women Completed NCT00375297 Phase 4 sildenafil
24 Statin Lowering Testosterone and Sexual Function Completed NCT02612714 Phase 4 Rosuvastatin
25 Levitra (Vardenafil, BAY38-9456) Partner Satisfaction Study II Completed NCT00377793 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
26 Daily Tadalafil on Body Fat and Lean Mass Completed NCT02554045 Phase 4 Tadalafil;Placebo
27 Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder Completed NCT01971099 Phase 4 tribulus terrestris
28 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris
29 SAMBA: Sexuality And Management of Benign Prostatic Hyperplasia With Alfuzosin Completed NCT00486785 Phase 4 Alfuzosin
30 Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients Completed NCT01468519 Phase 4 Insulin;Insulin
31 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
32 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
33 Sexual Functioning Study With Antidepressants Completed NCT00316160 Phase 4 Bupropion Hydrochloride Extended-release;Extended-release Venlafaxine
34 Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men Completed NCT01642576 Phase 4
35 Effects of Diet-induced Weight Loss in Obese Men Completed NCT01554865 Phase 4
36 Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554735 Phase 4
37 Wellbutrin XL Effects on SSRIs Induced Changes Completed NCT00456820 Phase 4 Wellbutrin XL
38 Effect of Vortioxetine, Paroxetine, and Placebo on Sexual Functioning in Healthy Volunteers Completed NCT02932904 Phase 4 Vortioxetine;Paroxetine;Placebo
39 Effects of Tribulus Terrestris on Sexual Function in Post-menopausal Women Completed NCT01407445 Phase 4 Placebo;Tribulus terrestris
40 Vardenafil and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
41 The Efficacy and Safety of New Herbal Formula (KBMSI-2) in the Treatment of Erectile Dysfunction Completed NCT02413099 Phase 4 KBMSI-2
42 A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction Completed NCT02224846 Phase 4 Tadalafil
43 Study Evaluating the Effects of Avanafil on Semen Parameters Completed NCT01768676 Phase 4 avanafil;Placebo
44 Research Evaluating a PDE5 Inhibitor for Erectile Dysfunction Completed NCT01698684 Phase 4 Placebo;Avanafil 100 mg;Avanafil 200 mg
45 A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China Completed NCT01352507 Phase 4 Tadalafil;Sildenafil
46 Efficacy and Safety of Lodenafil Carbonate in the Treatment of Erectile Dysfunction in Patients With Diabetes. Completed NCT01180283 Phase 4 lodenafil carbonate
47 Satisfaction, Confidence and Naturalness in Men With Psychogenic Erectile Dysfunction (ED) Completed NCT01153204 Phase 4 Sildenafil citrate
48 A Study in Erectile Dysfunction Completed NCT01130532 Phase 4 Tadalafil;Placebo
49 A Study in Patients With Erectile Dysfunction Completed NCT01122264 Phase 4 Tadalafil;Sildenafil Citrate
50 A Study of Tadalafil After Radical Prostatectomy Completed NCT01026818 Phase 4 Tadalafil;Placebo

Search NIH Clinical Center for Sexual Disorder

Genetic Tests for Sexual Disorder

Anatomical Context for Sexual Disorder

MalaCards organs/tissues related to Sexual Disorder:

41
Prostate, Spinal Cord, Testes, Brain, Liver, Heart, Endothelial

Publications for Sexual Disorder

Articles related to Sexual Disorder:

(show top 50) (show all 943)
# Title Authors Year
1
Prevalence of Sexual Dysfunction among Infertile Women in Iran: A Systematic Review and Meta-analysis. ( 30291686 )
2019
2
Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamus-pituitary-gonadal axis. ( 30365938 )
2019
3
Effect of delivery method on sexual dysfunction. ( 28965436 )
2019
4
Prevalence and correlates of sexual dysfunction in male patients with alcohol dependence syndrome: A cross-sectional study. ( 29736066 )
2018
5
Sexual dysfunction and phobic anxiety in breast cancer survivors. ( 30225895 )
2018
6
Sexual Dysfunction After Abdominal Aortic Aneurysm Surgical Repair: Current Knowledge and Future Directions. ( 29292207 )
2018
7
Diabetic autonomic neuropathy resulting in sexual dysfunction. ( 30256272 )
2018
8
Diabetic autonomic neuropathy resulting in sexual dysfunction. ( 30320635 )
2018
9
Sexual dysfunction in cervical dystonia and blepharospasm. ( 30464469 )
2018
10
Urinary incontinence as a cause of depression and sexual dysfunction: Questionnaire-based study. ( 30470663 )
2018
11
Re: Non-Alcoholic Fatty Liver Disease as a Risk Factor for Female Sexual Dysfunction in Premenopausal Women. ( 29642332 )
2018
12
Sexual Dysfunction and Childhood Trauma In Female Patients With Fibromyalgia. ( 30351275 )
2018
13
The association between fibromyalgia and female sexual dysfunction: a systematic review and meta-analysis of observational studies. ( 30467351 )
2018
14
Social Support for Female Sexual Dysfunction in Fibromyalgia. ( 29421939 )
2018
15
Long-Term Follow-Up of Sexual Dysfunction in Women Following Allogeneic Hematopoietic Stem Cell Transplantation. ( 30132158 )
2018
16
Satisfaction with sexual activity and sexual dysfunction in hematopoietic stem cell transplantation survivors and their partners: a couple study. ( 29403022 )
2018
17
Incidence of sexual dysfunction among patients with hidradenitis suppurativa: a population-based retrospective analysis. ( 29478285 )
2018
18
Sexual Dysfunction and Hypogonadism in Men With Diabetes. ( 29650102 )
2018
19
Subclinical hypothyroidism would not lead to female sexual dysfunction in Chinese women. ( 29370851 )
2018
20
Sexual dysfunction and infertility in the male spina bifida patient. ( 30505732 )
2018
21
Diagnostic evaluation of sexual dysfunction in the male partner in the setting of infertility: a committee opinion. ( 30316420 )
2018
22
Clinical Consultation Guide on Imaging in Male Infertility and Sexual dysfunction. ( 30327281 )
2018
23
Depression, sexual dysfunction and sexual quality of life in women with infertility. ( 29898709 )
2018
24
Sexual dysfunction and male infertility. ( 29532805 )
2018
25
Sexual Counselling in Women with Primary Infertility and Sexual Dysfunction: Use of the BETTER Model. ( 29757100 )
2018
26
Comparative Effectiveness of Antidepressant Medication versus Psychological Intervention on Depression Symptoms in Women with Infertility and Sexual Dysfunction. ( 29334200 )
2018
27
Sexual Dysfunction in Patients With Inflammatory Bowel Disease. ( 30312432 )
2018
28
Development of a Sexual Dysfunction Scale for Women With Inflammatory Bowel Disease. ( 30165525 )
2018
29
The Relevance of Sexual Dysfunction Related to Groin Pain After Inguinal Hernia Repair - The SexIHQ Short Form Questionnaire Assessment. ( 29616224 )
2018
30
Association Between Multiple Sclerosis and Risk of Female Sexual Dysfunction: A Systematic Review and Meta-Analysis. ( 30393105 )
2018
31
Identifying barriers to help-seeking for sexual dysfunction in multiple sclerosis. ( 30232609 )
2018
32
Factors Associated with Sexual Dysfunction in Individuals with Multiple Sclerosis: Implications for Assessment and Treatment. ( 30150904 )
2018
33
Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients. ( 30173209 )
2018
34
Management Strategies in Opioid Abuse and Sexual Dysfunction: A Review of Opioid-Induced Androgen Deficiency. ( 30057139 )
2018
35
The Risks of Using Herbal Supplements for Sexual Dysfunction Associated With Psychotropic Medications: A Case Report of ExtenZe Use and Priapism. ( 29553994 )
2018
36
Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis. ( 30484522 )
2018
37
High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study. ( 30173156 )
2018
38
Sexual dysfunction factors in patients with schizophrenia treated with second generation antipsychotics: not only prolactin. ( 30552811 )
2018
39
Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study. ( 30554232 )
2018
40
Evaluation of Sexual Dysfunction, Lower Urinary Tract Symptoms and Quality of Life in Men With Obstructive Sleep Apnea Syndrome and the Efficacy of Continuous Positive Airway Pressure Therapy. ( 30118776 )
2018
41
Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age. ( 30181035 )
2018
42
Effect of spinal anterior root stimulation and sacral deafferentation on bladder and sexual dysfunction in spinal cord injury. ( 29744665 )
2018
43
Sexual dysfunction and distress in premenopausal women with migraine: association with depression, anxiety and migraine-related disability. ( 30068979 )
2018
44
Sexual dysfunction in patients with systemic sclerosis ( 30541233 )
2018
45
The Risk of Sexual Dysfunction and Effectiveness of Treatment of Benign Prostatic Hyperplasia With Severe Lower Urinary Tract Dysfunction With Combination of Dutasteride and Solifenacin. ( 30415813 )
2018
46
A Prospective Study to Evaluate Sexual Dysfunction and Enlargement of Seminal Vesicles in Sexually Active Men Treated for Benign Prostatic Hyperplasia by Alpha-blockers. ( 28860050 )
2018
47
Understanding the relationship between BMI and sexual dysfunction: Can DSM-5 shed light into this topic? ( 30195481 )
2018
48
Sexual Dysfunction Among Young Men: Overview of Dietary Components Associated With Erectile Dysfunction. ( 29325831 )
2018
49
Sexual dysfunction and sex hormone abnormalities in patients with cirrhosis: Review of pathogenesis and management. ( 30468515 )
2018
50
Sexual Dysfunction Is Associated with Depression and Anxiety in Patients with Predialytic Chronic Kidney Disease. ( 30002571 )
2018

Variations for Sexual Disorder

Expression for Sexual Disorder

Search GEO for disease gene expression data for Sexual Disorder.

Pathways for Sexual Disorder

Pathways related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 KCNMA1 NOS3 OXT PDE5A RHOA ROCK2
2
Show member pathways
12.26 NOS3 PRL RHOA ROCK2
3
Show member pathways
12.04 HTR1A PDE4A RHOA ROCK2
4
Show member pathways
11.95 KCNMA1 NOS1 NOS3 PDE5A
5 11.81 NOS3 RHOA ROCK2
6 11.79 NOS1 RHOA ROCK2
7 11.77 NOS3 RHOA ROCK2
8 11.63 KLK3 RHOA ROCK2
9 11.49 NOS1 RHOA ROCK2
10
Show member pathways
11.34 ALDH7A1 NOS1 NOS3
11 11.33 RHOA SEPT3 SEPT6 SEPT8
12 10.91 NOS3 RHOA ROCK2
13
Show member pathways
10.55 KCNMA1 NOS1 NOS3 PDE5A
14 10.36 NOS1 NOS3
15 10.25 NOS1 NOS3 PDE5A

GO Terms for Sexual Disorder

Cellular components related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.87 NOS1 NOS3 RHOA ROCK2 SEPT3 SEPT6
2 secretory granule GO:0030141 9.54 KLK3 OXT PRL
3 caveola GO:0005901 9.43 KCNMA1 NOS1 NOS3
4 septin complex GO:0031105 9.33 SEPT3 SEPT6 SEPT8
5 septin filament array GO:0032160 9.13 SEPT3 SEPT6 SEPT8
6 septin ring GO:0005940 8.8 SEPT3 SEPT6 SEPT8

Biological processes related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 EDN1 PRL RHOA SLC6A4
2 negative regulation of angiogenesis GO:0016525 9.81 KLK3 PRL ROCK2
3 response to estradiol GO:0032355 9.79 OXT PRL SLC6A4
4 mitotic cytokinesis GO:0000281 9.71 SEPT3 SEPT6 SEPT8
5 response to lipopolysaccharide GO:0032496 9.71 EDN1 NOS1 NOS3 PRL
6 regulation of blood pressure GO:0008217 9.7 ACE EDN1 NOS3
7 regulation of sodium ion transport GO:0002028 9.64 NOS1 NOS3
8 nitric oxide mediated signal transduction GO:0007263 9.63 NOS1 NOS3
9 regulation of blood vessel size GO:0050880 9.62 EDN1 NOS3
10 negative regulation of calcium ion transport GO:0051926 9.61 NOS1 NOS3
11 neurotransmitter biosynthetic process GO:0042136 9.6 NOS1 SLC6A4
12 positive regulation of renal sodium excretion GO:0035815 9.59 EDN1 OXT
13 nitric oxide biosynthetic process GO:0006809 9.58 NOS1 NOS3
14 response to transforming growth factor beta GO:0071559 9.58 EDN1 ROCK2
15 negative regulation of potassium ion transport GO:0043267 9.57 NOS1 NOS3
16 positive regulation of guanylate cyclase activity GO:0031284 9.56 NOS1 NOS3
17 multicellular organismal response to stress GO:0033555 9.55 NOS1 PRL
18 negative regulation of blood pressure GO:0045776 9.54 NOS1 NOS3 OXT
19 arginine catabolic process GO:0006527 9.51 NOS1 NOS3
20 positive regulation of cardiac muscle hypertrophy GO:0010613 9.5 EDN1 PDE5A ROCK2
21 negative regulation of biomineral tissue development GO:0070168 9.49 NOS3 ROCK2
22 negative regulation of hydrolase activity GO:0051346 9.48 NOS1 NOS3
23 positive regulation of prostaglandin secretion GO:0032308 9.46 EDN1 OXT
24 sperm ejaculation GO:0042713 9.43 OXT SLC6A4
25 vasoconstriction GO:0042310 9.43 EDN1 HTR1A SLC6A4
26 response to hypoxia GO:0001666 9.35 EDN1 KCNMA1 NOS1 RHOA SLC6A4
27 septin ring assembly GO:0000921 9.33 SEPT3 SEPT6 SEPT8
28 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.8 EDN1 NOS3 RHOA

Molecular functions related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ALDH7A1 EDN1 HTR1A KCNMA1 KLK3 NOS1
2 GTPase activity GO:0003924 9.78 RHOA SEPT3 SEPT6 SEPT8
3 hormone activity GO:0005179 9.67 EDN1 OXT PRL
4 protein-containing complex scaffold activity GO:0032947 9.54 SEPT3 SEPT6 SEPT8
5 FMN binding GO:0010181 9.46 NOS1 NOS3
6 serotonin binding GO:0051378 9.43 HTR1A SLC6A4
7 arginine binding GO:0034618 9.4 NOS1 NOS3
8 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS1 NOS3
9 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
10 tetrahydrobiopterin binding GO:0034617 9.16 NOS1 NOS3
11 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Sexual Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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