Aliases & Classifications for Sexual Disorder

MalaCards integrated aliases for Sexual Disorder:

Name: Sexual Disorder 12 15
Sexual Dysfunction 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060043
UMLS 71 C0549622

Summaries for Sexual Disorder

Disease Ontology : 12 A disease of mental health that involves the impairment in normal sexual functioning.

MalaCards based summary : Sexual Disorder, also known as sexual dysfunction, is related to inhibited male orgasm and mental depression, and has symptoms including increased libido An important gene associated with Sexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Calcium signaling pathway and Monoamine GPCRs. The drugs Fenofibrate and Udenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, breast and spinal cord, and related phenotypes are endocrine/exocrine gland and nervous system

Related Diseases for Sexual Disorder

Diseases related to Sexual Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 497)
# Related Disease Score Top Affiliating Genes
1 inhibited male orgasm 33.0 OXT HTR2C HTR1A
2 mental depression 31.6 OXT HTR2C HTR2A HTR1A
3 lipid metabolism disorder 31.2 SHBG PDE5A INS ACE
4 major depressive disorder 31.1 PRL OXT NOS1 HTR2C HTR2A HTR1A
5 amenorrhea 31.1 SHBG PRL INS GNRH1
6 generalized anxiety disorder 31.1 HTR2C HTR2A HTR1A
7 prostatitis 31.0 PRL PDE5A MIR141 KLK3
8 premenstrual tension 31.0 SHBG GNRH1
9 prostatic hypertrophy 31.0 SHBG PDE5A KLK3
10 constipation 31.0 NOS1 INS HTR2A HTR1A
11 premature ejaculation 30.9 PDE5A OXT HTR2C HTR1A
12 polycystic ovary syndrome 30.9 SHBG PRL INS GNRH1
13 androgenic alopecia 30.9 SHBG PRL KLK3 INS
14 panic disorder 30.8 PRL HTR2C HTR2A HTR1A ACE
15 congestive heart failure 30.8 PDE5A NOS3 INS ACE
16 hypothyroidism 30.8 SHBG PRL INS GNRH1 ACE
17 schizoaffective disorder 30.8 PRL INS HTR2A HTR1A
18 chronic fatigue syndrome 30.7 PRL INS HTR2A HTR1A
19 psychotic disorder 30.7 PRL OXT NOS1 HTR2C HTR2A HTR1A
20 postpartum depression 30.7 PRL OXT HTR1A
21 inhibited female orgasm 30.7 SHBG PRL EHD4
22 hyperandrogenism 30.7 SHBG PRL INS GNRH1
23 obsessive-compulsive disorder 30.7 PRL OXT HTR2C HTR2A HTR1A
24 hypopituitarism 30.7 SHBG PRL INS GNRH1
25 prostatic hyperplasia, benign 30.6 SHBG PDE5A KLK3
26 hypoactive sexual desire disorder 30.6 SHBG PRL PDE5A OXT HTR2C HTR2A
27 gynecomastia 30.6 SHBG PRL KLK3 GNRH1
28 peripheral vascular disease 30.6 NOS3 INS HTR2A ACE
29 cardiovascular system disease 30.6 SHBG PDE5A NOS3 INS ACE
30 dysthymic disorder 30.6 HTR2A HTR1A EHD4
31 varicocele 30.6 SHBG PRL NOS3 GNRH1
32 pulmonary disease, chronic obstructive 30.6 PDE5A PDE4A INS ALDH7A1 ACE
33 cryptorchidism, unilateral or bilateral 30.6 SHBG PRL INS GNRH1
34 bipolar i disorder 30.5 HTR2C HTR2A HTR1A
35 acute cystitis 30.5 KLK3 INS ACE
36 bipolar disorder 30.5 SHBG PRL NOS1 HTR2C HTR2A HTR1A
37 vaginal discharge 30.5 OXT GNRH1 EHD4
38 sleep disorder 30.5 PRL INS HTR2C HTR2A HTR1A ACE
39 social phobia 30.5 PRL OXT HTR1A
40 anovulation 30.5 SHBG PRL INS GNRH1
41 pedophilia 30.5 PRL OXT
42 bulimia nervosa 30.5 PRL OXT INS HTR2C HTR2A
43 acromegaly 30.5 SHBG PRL INS GNRH1
44 depression 30.4 NOS1 HTR2C HTR2A HTR1A
45 hypogonadism 30.4 SHBG PRL PDE5A INS GNRH1
46 melancholia 30.4 PRL HTR2A HTR1A
47 arteries, anomalies of 30.4 NOS3 MIR141 INS ACE
48 estrogen excess 30.4 SHBG PRL GNRH1
49 hypochondriasis 30.4 HTR2C HTR2A HTR1A
50 raynaud phenomenon 30.4 PDE5A HTR2A

Graphical network of the top 20 diseases related to Sexual Disorder:



Diseases related to Sexual Disorder

Symptoms & Phenotypes for Sexual Disorder

UMLS symptoms related to Sexual Disorder:


increased libido

MGI Mouse Phenotypes related to Sexual Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 ACE EHD4 GNRH1 HTR2A INS NOS1
2 nervous system MP:0003631 9.7 GNRH1 HTR1A HTR2C INS NOS1 NOS3
3 renal/urinary system MP:0005367 9.17 ACE EHD4 GNRH1 INS NOS1 NOS3

Drugs & Therapeutics for Sexual Disorder

Drugs for Sexual Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 340)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fenofibrate Approved Phase 4 49562-28-9 3339
2
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
3
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
4
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
5
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Polyestradiol phosphate Approved Phase 4 28014-46-2
8
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
9
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
10
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
11
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
12
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
13
Zinc Approved, Investigational Phase 4 7440-66-6 32051
14
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
15
Tibolone Approved, Investigational Phase 4 5630-53-5
16
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
17
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
18
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
19
Bisoprolol Approved Phase 4 66722-44-9 2405
20
Pramipexole Approved, Investigational Phase 4 104632-26-0 119570 59868
21
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
22
Estrone Approved Phase 4 53-16-7 5870
23
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
24
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
25
Sertraline Approved Phase 4 79617-96-2 68617
26
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
27 Adrenergic beta-1 Receptor Antagonists Phase 4
28 Sympatholytics Phase 4
29 Quetiapine Fumarate Phase 4 111974-72-2
30 Antidepressive Agents Phase 4
31 Psychotropic Drugs Phase 4
32 Cytochrome P-450 Enzyme Inhibitors Phase 4
33 Estradiol 17 beta-cypionate Phase 4
34 Estradiol 3-benzoate Phase 4
35 Rosuvastatin Calcium Phase 4 147098-20-2
36 Hypolipidemic Agents Phase 4
37 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
38 Lipid Regulating Agents Phase 4
39 Anticholesteremic Agents Phase 4
40 Venlafaxine Hydrochloride Phase 4
41 Vardenafil Dihydrochloride Phase 4
42 insulin Phase 4
43 Hypoglycemic Agents Phase 4
44 Insulin, Globin Zinc Phase 4
45 Central Nervous System Stimulants Phase 4
46 Neurotransmitter Agents Phase 4
47 Adrenergic Agents Phase 4
48 Adrenergic Antagonists Phase 4
49 Antihypertensive Agents Phase 4
50 Pharmaceutical Solutions Phase 4

Interventional clinical trials:

(show top 50) (show all 471)
# Name Status NCT ID Phase Drugs
1 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
2 Effect of Fenofibrate and Rosuvastatin on Sexual Dysfunction in Hyperlipidemic Patients. A Randomized Trial Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
3 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
4 The Effect of Treatment for ED on Quality of Life and Satisfaction in a Group of Patients Without Prior Complaints of Sexual Dysfunction Unknown status NCT00313898 Phase 4 sildenafil (viagra)
5 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
6 Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
7 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
8 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
9 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris
10 Treatment of Sexual Dysfunction Secondary to Antidepressant Pharmacotherapy: A Double-blind Comparison of Requip (Ropinirole) vs. Placebo in Patients Taking SSRI Antidepressants Completed NCT00334048 Phase 4 Ropinirole (Requip)
11 Randomized Double Blind Placebo Controlled Study of Sildenafil for Treatment of Serotonergic Reuptake Inhibitor Associated Sexual Dysfunction in Women With Major Depression Treated to Remission Completed NCT00375297 Phase 4 sildenafil
12 Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men Completed NCT01642576 Phase 4
13 A 14 Week Open-Label Study to Evaluate the Tolerability of Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction in Generalized Anxiety Disorder Patients Completed NCT00174850 Phase 4 Gaitril
14 Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder Completed NCT01971099 Phase 4 tribulus terrestris
15 A Twelve-week, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group, Active Controlled, Escalating Dose Study to Compare the Effects on Sexual Functioning of Bupropion Hydrochloride Extended-release (WELLBUTRIN XL, 150-450 mg/Day) and Extended-release Venlafaxine (EFFEXOR XR, 75-225 mg/Day) in Subjects With Major Depressive Disorder Completed NCT00316160 Phase 4 Bupropion Hydrochloride Extended-release;Extended-release Venlafaxine
16 Statin Therapy is Associated With Low Testosterone and Sexual Function in Men With Type 2 Diabetes Completed NCT02612714 Phase 4 Rosuvastatin
17 Wellbutrin XL Effects on SSRIs Induced Changes in the Reactivity of the Frontal Cortex and Limbic System to Emotional Stimuli: An fMRI Study Completed NCT00456820 Phase 4 Wellbutrin XL
18 A Randomized, Double Blind, Parallel Group Study of Vardenafil Flexible Dose Versus Placebo in Males With Erectile Dysfunction and Their Female Partners Sexual Quality of Life. PARTNER II Completed NCT00377793 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
19 Aripiprazole for the Treatment of Schizophrenia With Co-Morbid Social Anxiety Completed NCT00177008 Phase 4 Aripiprazole
20 A Pilot Study of the Efficacy and Tolerability of Bupropion Extended Release (Wellbutrin XL) for the Treatment of Major Depressive Disorder in Women With Breast Cancer Completed NCT00234195 Phase 4 bupropion extended release (Wellbutrin XL)
21 The Effects of Diet-induced Weight Loss on Metabolic and Inflammatory Profile, Endothelial, Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554865 Phase 4
22 The Effects of Lifestyle-modification Induced Weight Loss on Metabolic and Inflammatory Profile, Endothelial, Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554735 Phase 4
23 Study of the Effects of Tribulus Terrestris on Sexuality in Postmenopausal Women Completed NCT01407445 Phase 4 Placebo;Tribulus terrestris
24 Evaluation of the Effects of Monopolar Transurethral Resection Versus Bipolar Transurethral Resection and Holmium Laser Enucleation of the Prostate on Urinary and Sexual Function; a Prospective Comparative Study. Completed NCT01810068 Phase 4
25 Effects of Continuous Subcutaneous Insulin Infusion (CSII) on Erectile Dysfunction in T2DM Patients: A Prospective, Exploratory, Controlled Trial Completed NCT01468519 Phase 4 Insulin;Insulin
26 An Integrated Approach With Vardenafil Orodispersible and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
27 Study on the Effect of Combined Oral Contraceptive Therapy on Female Sexuality, Body Image and Mental Health Completed NCT02613039 Phase 4 Combined Estrogen-Progestin Oral Contraceptives
28 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
29 The Effect of Armodafinil (Nuvigil) on Fatigue and Quality of Life in Peri- and Postmenopausal Women Completed NCT01460628 Phase 4 Armodafinil
30 Agomelatine Treatment of Major Depressive Episodes in the Course of Schizophrenic Psychoses (AGOPSYCH) Completed NCT01822418 Phase 4 agomelatine
31 Effect of Serotonin Reuptake Inhibitors on Gonadal Steroid Hormones Completed NCT00611975 Phase 4 Fluoxetine;Bupropion
32 A Study of Sertraline to Prevent PTSD Completed NCT00182078 Phase 4 Placebo;Sertraline
33 The Impact of Different Hormone Therapy Regimens on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder Recruiting NCT01822288 Phase 4 Tibolone;Estradiol & medroxyprogesterone acetate
34 Sexual Dysfunction in Gynecologic Oncology Patients Recruiting NCT03801031 Phase 4 Lidocaine Topical;Placebo
35 BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function (BETAMI) Recruiting NCT03646357 Phase 4 Betablocker
36 Treating Where it Hurts: A Randomized Blinded Clinical Trial of Local Estrogen to the Vulvar Vestibule for Dyspareunia in Postmenopausal Women Active, not recruiting NCT03240081 Phase 4 50mcg estradiol cream;100mcg estradiol cream
37 Post-Prostatectomy Erectile Dysfunction: Effect of Hyperbaric Oxygen Therapy Active, not recruiting NCT00906269 Phase 4 Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
38 A Multicenter, Randomized, Double-blind, Placebo-controlled Study: Evaluation of the Efficacy and Safety of Agomelatine in the Treatment of Sleep Disorders and Depression in Patients With Parkinson's Disease Not yet recruiting NCT03977441 Phase 4 Agomelatine or PIacebo
39 Ospemifene Versus Conjugated Estrogens in the Treatment of Postmenopausal Sexual Dysfunction Terminated NCT03018106 Phase 4 Ospemifene;Vaginal conjugated estrogens
40 Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction Terminated NCT00398632 Phase 4 Duloxetine
41 A Randomized, Double-Blind, Active Controlled Clinical Trial of Switching to Vilazodone for Antidepressant-Associated Sexual Dysfunction Terminated NCT01856127 Phase 4 Vilazodone;Sertraline
42 An Open-label Study to Determine the Effect of Switching to Aripiprazole Once Monthly for Subjects With Schizophrenia Experiencing Worsening Sexual Dysfunction With Invega Sustenna or Risperdal Consta Terminated NCT02472652 Phase 4 Abilify Maintena
43 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
44 Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis Terminated NCT00854750 Phase 4 ACTHAR;ACTHAR;ACTHAR;ACTHAR
45 THE INFLUENCE OF COGNITIVE BEHAVIORAL THERAPY IN SEXUAL DYSFUNCTION FEMALE: Randomized Clinical Trial Unknown status NCT02613546 Phase 2, Phase 3
46 Self-care Programs in Oncology: a Guided Internet-delivered Individually-tailored Acceptance and Commitment Therapy (ACT)-Influenced Cognitive Behavioural Intervention to Improve Psychosocial Outcomes in Breast Cancer Survivors Unknown status NCT03275727 Phase 2, Phase 3
47 The Role of 5-Alpha Reductase in Mediating Testosterone Actions Unknown status NCT00070733 Phase 3 testosterone enanthate;duastride
48 Evaluate the Long-term (3 Months) Efficacy of L-threo DOPS (DroxiDopa) on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With Multiple System Atrophy (MSA). Comparative Study Versus Placebo Unknown status NCT02071459 Phase 2, Phase 3 L-Threo DOPS;placebo
49 Efficacy and Safety of a Second Series of Low Intensity Extracorporeal Shock Wave Therapy (LI-ESWT) Treatment for Erectile Dysfunction Patients Who Were Partial Responders to the Initial Treatment. Unknown status NCT01601262 Phase 3
50 Low Intensity Extracorporeal Shock Wave Therapy for the Treatment of Erectile Dysfunction- 4 Arms Unknown status NCT01442077 Phase 3

Search NIH Clinical Center for Sexual Disorder

Genetic Tests for Sexual Disorder

Anatomical Context for Sexual Disorder

MalaCards organs/tissues related to Sexual Disorder:

40
Prostate, Breast, Spinal Cord, Heart, Brain, Testes, Kidney

Publications for Sexual Disorder

Articles related to Sexual Disorder:

(show top 50) (show all 10066)
# Title Authors PMID Year
1
Women's sexual experiences as a side effect of contraception in low- and middle-income countries: evidence from a systematic scoping review. 61
32530748 2020
2
Association between sexuality knowledge and sexual dysfunction in hematopoietic stem cell transplantation patients and their partners. 61
32171555 2020
3
Sexual Dysfunction and Bother Due to Erectile Dysfunction in the Healthy Elderly Male Population: Prevalence from a Systematic Review. 61
30878347 2020
4
Prostatic irradiation-induced sexual dysfunction: A review and multidisciplinary guide to management in the radical radiotherapy era (Part II on Urological Management). 61
32549795 2020
5
Prostatic irradiation-induced sexual dysfunction: A review and multidisciplinary guide to management in the radical radiotherapy era (Part III on Psychosexual Therapy and the Masculine Self-Esteem). 61
32536830 2020
6
Evaluation of the potential aphrodisiac activity of sesquiterpenoids from roots of Ferula huber-morathii Peşmen in male rats. 61
32298751 2020
7
Sexual dysfunction after stroke-A biopsychosocial perspective. 61
32100415 2020
8
Erectile dysfunction pre and post kidney transplant recipients in Duhok city; cross sectional study. 61
32477507 2020
9
Update of the position paper on arterial hypertension and erectile dysfunction. 61
32073535 2020
10
Statistical Mediators of the Association Between Mindfulness and Sexual Experiences in Men with Impaired Sexual Function. 61
31713094 2020
11
Sexual Dysfunction and Fertility Problems in Men with Inflammatory Bowel Disease. 61
30929327 2020
12
Understanding symptomatic experience, impact, and emotional response in recently diagnosed metastatic castration-resistant prostate cancer: a qualitative study. 61
31659445 2020
13
Pharmacological treatment of female sexual dysfunction: a critical analysis of the placebo and nocebo effects. 61
32578685 2020
14
Quality of life and sexual dysfunction in gynaecological cancer patients: a psychosomatic approach. 61
32568731 2020
15
Biofeedback versus electrical stimulation for sexual dysfunction: a randomized clinical trial. 61
32529563 2020
16
Consent Including Sexual Dysfunction and Pain with Sexual Activity after Inguinal Hernia Repair? 61
32173251 2020
17
Effects of demographic and obstetric variables with body image on sexual dysfunction in pregnancy: A cross-sectional and comparative study. 61
32155306 2020
18
Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control. 61
32560383 2020
19
Peyronie's disease: Contemporary evaluation and management. 61
32253786 2020
20
Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. 61
31792367 2020
21
Adjuvant immunotherapy: the sting in the tail. 61
32388064 2020
22
The effect of underweight on female and male reproduction. 61
32289345 2020
23
Health-Related Quality of Life in Patients with the Bladder Exstrophy-Epispadias Complex and Relationship to Incontinence and Sexual Factors: A Review of the Recent Literature. 61
32564346 2020
24
Re: The Risk of Sexual Dysfunction and Effectiveness of Treatment of Benign Prostatic Hyperplasia with Severe Lower Urinary Tract Dysfunction with Combination of Dutasteride and Solifenacin. 61
32182172 2020
25
Characteristics of Penile Growth in Pubertal Rats and a Non-Invasive Method to Lengthen the Penis. 61
32578359 2020
26
Development and initial psychometric testing of a body-image domain within an electronic pelvic floor questionnaire (ePAQ-pelvic floor). 61
32125492 2020
27
Men's experiences of surviving testicular cancer: an integrated literature review. 61
31823122 2020
28
Unmet needs in sexual health in bladder cancer patients: a systematic review of the evidence. 61
32493286 2020
29
Does THA Affect Sexual Dysfunction in Female Patients With DDH? 61
32057603 2020
30
Pelvic organ prolapse and sexual function. 61
32555435 2020
31
The cytotoxicity of advanced glycation end products was attenuated by UCMSCs in human vaginal wall fibroblasts by inhibition of an inflammatory response and activation of PI3K/AKT/PTEN. 61
32493859 2020
32
Self-Reported Sexual Function in Sexually Active Male Hodgkin Lymphoma Survivors. 61
32507555 2020
33
Impact of diabetes mellitus on sexuality in a developing country setting: A case-control study in Calabar, Nigeria. 61
32525125 2020
34
Sexual impairment in patients with hidradenitis suppurativa: a systematic review. 61
32531099 2020
35
Effects of Hypothyroidism and Subclinical Hypothyroidism on Sexual Function: A Meta-Analysis of Studies Using the Female Sexual Function Index. 61
32299686 2020
36
Female Sexual Dysfunction: Pharmacologic and Therapeutic Interventions. 61
32541291 2020
37
Title: Female Sexual Dysfunction - Awareness and Education Among Resident Physicians. 61
32531465 2020
38
MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist. 61
32234976 2020
39
The effect of a levonorgestrel-releasing intrauterine device on female sexual function. 61
32498582 2020
40
Carbon dioxide laser treatment for vulvovaginal atrophy in women treated for breast cancer: Preliminary results of the feasibility EPIONE trial. 61
32513482 2020
41
Total mesorectal excision plus lateral lymph node dissection vs TME on rectal cancer patients: a meta-analysis. 61
32356120 2020
42
Treatment-induced symptoms, depression and age as predictors of sexual problems in premenopausal women with early breast cancer receiving adjuvant endocrine therapy. 61
32274665 2020
43
Systematic review of clinical practice guidelines for colorectal and anal cancer: the extent of recommendations for managing long-term symptoms and functional impairments. 61
32025805 2020
44
The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China. 61
32533117 2020
45
Instruments for Screening, Diagnosis, and Management of Patients with Generalized Acquired Hypoactive Sexual Desire Disorder. 61
32096691 2020
46
Chronic exposure to paroxetine or bupropion modulates the pubertal maturation and the reproductive system in female rats. 61
32299777 2020
47
Women's Sexual Desire, Trauma Exposure, and Posttraumatic Stress Disorder. 61
32216146 2020
48
Female Orgasm and Overall Sexual Function and Habits: A Descriptive Study of a Cohort of U.S. Women. 61
32201145 2020
49
Clitoral Epidermal Inclusion Cyst Leading to Anorgasmia: A Case Report and Literature Review. 61
32028052 2020
50
[Chronic prostatitis/chronic pelvic pain syndrome]. 61
32495006 2020

Variations for Sexual Disorder

Expression for Sexual Disorder

Search GEO for disease gene expression data for Sexual Disorder.

Pathways for Sexual Disorder

GO Terms for Sexual Disorder

Cellular components related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.8 SEPTIN8 SEPTIN3 NOS1 HTR2C HTR2A HTR1A
2 presynapse GO:0098793 9.56 SEPTIN8 SEPTIN6 SEPTIN3 HTR2A
3 caveola GO:0005901 9.54 NOS3 NOS1 HTR2A
4 cell division site GO:0032153 9.33 SEPTIN8 SEPTIN6 SEPTIN3
5 septin complex GO:0031105 9.13 SEPTIN8 SEPTIN6 SEPTIN3
6 septin ring GO:0005940 8.8 SEPTIN8 SEPTIN6 SEPTIN3

Biological processes related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 PRL PDE5A PDE4A OXT INS HTR2C
2 G protein-coupled receptor signaling pathway GO:0007186 10.05 PDE4A OXT INS HTR2C HTR2A HTR1A
3 positive regulation of cell proliferation GO:0008284 9.98 PRL MIR141 INS HTR2A HTR1A
4 female pregnancy GO:0007565 9.77 PRL OXT GNRH1
5 cellular protein localization GO:0034613 9.72 SEPTIN8 SEPTIN6 SEPTIN3
6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.67 HTR2C HTR2A HTR1A
7 negative regulation of calcium ion transport GO:0051926 9.6 NOS3 NOS1
8 nitric oxide biosynthetic process GO:0006809 9.58 NOS3 NOS1
9 sleep GO:0030431 9.57 OXT HTR2A
10 positive regulation of guanylate cyclase activity GO:0031284 9.56 NOS3 NOS1
11 negative regulation of hydrolase activity GO:0051346 9.54 NOS3 NOS1
12 negative regulation of blood pressure GO:0045776 9.54 OXT NOS3 NOS1
13 response to prostaglandin E GO:0034695 9.52 OXT GNRH1
14 arginine catabolic process GO:0006527 9.48 NOS3 NOS1
15 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.43 HTR2C HTR2A
16 cytoskeleton-dependent cytokinesis GO:0061640 9.43 SEPTIN8 SEPTIN6 SEPTIN3
17 regulation of neurological system process GO:0031644 9.4 NOS3 HTR2C
18 behavior GO:0007610 9.33 HTR2C HTR2A HTR1A
19 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.32 HTR2C HTR2A
20 negative regulation of potassium ion transport GO:0043267 9.13 NOS3 NOS1 HTR2A
21 serotonin receptor signaling pathway GO:0007210 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.69 HTR2C HTR2A HTR1A
2 molecular adaptor activity GO:0060090 9.65 SEPTIN8 SEPTIN6 SEPTIN3
3 drug binding GO:0008144 9.63 HTR2C HTR2A ACE
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.54 NOS3 NOS1
5 FMN binding GO:0010181 9.52 NOS3 NOS1
6 arginine binding GO:0034618 9.49 NOS3 NOS1
7 hormone activity GO:0005179 9.46 PRL OXT INS GNRH1
8 NADPH-hemoprotein reductase activity GO:0003958 9.43 NOS3 NOS1
9 G protein-coupled serotonin receptor activity GO:0004993 9.43 HTR2C HTR2A HTR1A
10 cadmium ion binding GO:0046870 9.4 NOS3 NOS1
11 tetrahydrobiopterin binding GO:0034617 9.37 NOS3 NOS1
12 nitric-oxide synthase activity GO:0004517 9.32 NOS3 NOS1
13 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
14 serotonin binding GO:0051378 8.8 HTR2C HTR2A HTR1A

Sources for Sexual Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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