Aliases & Classifications for Sexual Disorder

MalaCards integrated aliases for Sexual Disorder:

Name: Sexual Disorder 12 15
Sexual Dysfunction 17 71


External Ids:

Disease Ontology 12 DOID:0060043
UMLS 71 C0549622

Summaries for Sexual Disorder

Disease Ontology : 12 A disease of mental health that involves the impairment in normal sexual functioning.

MalaCards based summary : Sexual Disorder, also known as sexual dysfunction, is related to inhibited male orgasm and apnea, obstructive sleep, and has symptoms including increased libido An important gene associated with Sexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Oxytocin signaling pathway and Prolactin Signaling Pathway. The drugs Fenofibrate and Udenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, breast and spinal cord, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Sexual Disorder

Diseases related to Sexual Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 485)
# Related Disease Score Top Affiliating Genes
1 inhibited male orgasm 32.9 SHBG OXT HTR2C HTR1A
2 apnea, obstructive sleep 32.8 NOS3 INS HTR2A ACE
3 mental depression 31.5 OXT HTR2C HTR2A HTR1A
4 amenorrhea 31.1 SHBG PRL INS
5 lipid metabolism disorder 31.1 SHBG PDE5A INS ACE
6 prostatitis 31.0 PRL PDE5A KLK3
7 generalized anxiety disorder 31.0 HTR2C HTR2A HTR1A
8 major depressive disorder 31.0 PRL OXT NOS1 HTR2C HTR2A HTR1A
9 premature ejaculation 30.9 PDE5A OXT HTR2C HTR1A
10 urethral stricture 30.9 PDE5A KLK3 ADRA1D
11 vascular disease 30.9 NOS3 NOS1 INS HTR2A ACE
12 androgenic alopecia 30.8 SHBG PRL KLK3 INS
13 sleep apnea 30.8 NOS3 INS HTR2C HTR2A ACE
14 congestive heart failure 30.8 PDE5A NOS3 INS ACE
15 schizoaffective disorder 30.7 PRL INS HTR2A HTR1A
16 postpartum depression 30.7 PRL OXT HTR1A
17 inhibited female orgasm 30.7 SHBG PRL EHD4
18 hypopituitarism 30.7 SHBG PRL INS
19 panic disorder 30.6 PRL HTR2C HTR2A HTR1A ACE
20 psychotic disorder 30.6 PRL OXT NOS1 HTR2C HTR2A HTR1A
21 gynecomastia 30.6 SHBG PRL KLK3
22 prostatic hyperplasia, benign 30.6 SHBG PDE5A KLK3
23 postmenopausal atrophic vaginitis 30.6 SHBG OXT
24 chronic fatigue syndrome 30.6 INS HTR2A HTR1A
25 varicocele 30.6 SHBG PRL NOS3
26 hyperandrogenism 30.6 SHBG PRL INS
27 anovulation 30.5 SHBG PRL INS
28 dysthymic disorder 30.5 HTR2A HTR1A EHD4
29 pulmonary disease, chronic obstructive 30.5 PDE5A PDE4A INS ALDH7A1 ACE
30 cardiovascular system disease 30.5 SHBG PDE5A NOS3 INS ACE
31 peripheral vascular disease 30.5 NOS3 INS HTR2A ACE
32 glucose intolerance 30.5 SHBG NOS3 INS ACE
33 acute cystitis 30.5 KLK3 INS ACE
34 obsessive-compulsive disorder 30.5 PRL OXT HTR2C HTR2A HTR1A
35 bipolar i disorder 30.5 HTR2C HTR2A HTR1A
36 neurotic disorder 30.5 INS HTR2A HTR1A
37 hypoactive sexual desire disorder 30.5 SHBG PDE5A OXT HTR2C HTR2A HTR1A
38 social phobia 30.5 PRL OXT HTR1A
39 bipolar disorder 30.5 SHBG PRL NOS1 HTR2C HTR2A HTR1A
40 hypogonadism 30.5 SHBG PRL PDE5A KLK3 INS
41 bulimia nervosa 30.4 PRL OXT INS HTR2C HTR2A
42 hyperthyroidism 30.4 SHBG PRL INS
43 sleep disorder 30.4 PRL INS HTR2C HTR2A HTR1A ACE
44 depression 30.4 NOS1 HTR2C HTR2A HTR1A
45 melancholia 30.4 PRL HTR2A HTR1A
46 somatization disorder 30.4 OXT HTR2A HTR1A
47 atypical depressive disorder 30.3 HTR2C HTR2A HTR1A
48 paranoid schizophrenia 30.3 PRL HTR2A HTR1A
49 angina pectoris 30.3 NOS3 INS ACE
50 hypercholesterolemia, familial, 1 30.3 NOS3 INS ACE

Graphical network of the top 20 diseases related to Sexual Disorder:

Diseases related to Sexual Disorder

Symptoms & Phenotypes for Sexual Disorder

UMLS symptoms related to Sexual Disorder:

increased libido

MGI Mouse Phenotypes related to Sexual Disorder:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 ACE ADRA1D HTR1A HTR2A HTR2C INS
2 nervous system MP:0003631 9.73 ADRA1D HTR1A HTR2C INS NOS1 NOS3
3 renal/urinary system MP:0005367 9.17 ACE EHD4 INS NOS1 NOS3 OXT

Drugs & Therapeutics for Sexual Disorder

Drugs for Sexual Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 363)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Fenofibrate Approved Phase 4 49562-28-9 3339
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
Zinc Approved, Investigational Phase 4 7440-66-6 32051
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
Tibolone Approved, Investigational Phase 4 5630-53-5
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
Bisoprolol Approved Phase 4 66722-44-9 2405
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Estrone Approved Phase 4 53-16-7 5870
Tamoxifen Approved Phase 4 10540-29-1 2733526
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
Sertraline Approved Phase 4 79617-96-2 68617
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
26 Quetiapine Fumarate Phase 4 111974-72-2
27 Psychotropic Drugs Phase 4
28 Antidepressive Agents Phase 4
29 Cytochrome P-450 Enzyme Inhibitors Phase 4
30 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
31 Rosuvastatin Calcium Phase 4 147098-20-2
32 Hypolipidemic Agents Phase 4
33 Anticholesteremic Agents Phase 4
34 Lipid Regulating Agents Phase 4
35 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
36 Dopamine Uptake Inhibitors Phase 4
37 Venlafaxine Hydrochloride Phase 4
38 Vardenafil Dihydrochloride Phase 4
39 insulin Phase 4
40 Insulin, Globin Zinc Phase 4
41 Hypoglycemic Agents Phase 4
42 Central Nervous System Stimulants Phase 4
43 Cytochrome P-450 CYP3A Inducers Phase 4
44 Neurotransmitter Agents Phase 4
45 Adrenergic Antagonists Phase 4
46 Adrenergic Agents Phase 4
47 Autonomic Agents Phase 4
48 Sympatholytics Phase 4
49 Adrenergic beta-1 Receptor Antagonists Phase 4
50 Adrenergic beta-Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 449)
# Name Status NCT ID Phase Drugs
1 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
2 Effect of Fenofibrate and Rosuvastatin on Sexual Dysfunction in Hyperlipidemic Patients. A Randomized Trial Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
3 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
4 The Effect of Treatment for ED on Quality of Life and Satisfaction in a Group of Patients Without Prior Complaints of Sexual Dysfunction Unknown status NCT00313898 Phase 4 sildenafil (viagra)
5 Study on the Effect of Combined Oral Contraceptive Therapy on Female Sexuality, Body Image and Mental Health Unknown status NCT02613039 Phase 4 Combined Estrogen-Progestin Oral Contraceptives
6 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
7 Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
8 Changes of Heart Rate Variability in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine Unknown status NCT01047215 Phase 4 Aripiprazole; Quetiapine
9 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
10 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris
11 Treatment of Sexual Dysfunction Secondary to Antidepressant Pharmacotherapy: A Double-blind Comparison of Requip (Ropinirole) vs. Placebo in Patients Taking SSRI Antidepressants Completed NCT00334048 Phase 4 Ropinirole (Requip)
12 Randomized Double Blind Placebo Controlled Study of Sildenafil for Treatment of Serotonergic Reuptake Inhibitor Associated Sexual Dysfunction in Women With Major Depression Treated to Remission Completed NCT00375297 Phase 4 sildenafil
13 Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men Completed NCT01642576 Phase 4
14 A 14 Week Open-Label Study to Evaluate the Tolerability of Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction in Generalized Anxiety Disorder Patients Completed NCT00174850 Phase 4 Gaitril
15 A Twelve-week, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group, Active Controlled, Escalating Dose Study to Compare the Effects on Sexual Functioning of Bupropion Hydrochloride Extended-release (WELLBUTRIN XL, 150-450 mg/Day) and Extended-release Venlafaxine (EFFEXOR XR, 75-225 mg/Day) in Subjects With Major Depressive Disorder Completed NCT00316160 Phase 4 Bupropion Hydrochloride Extended-release;Extended-release Venlafaxine
16 Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder Completed NCT01971099 Phase 4 tribulus terrestris
17 Wellbutrin XL Effects on SSRIs Induced Changes in the Reactivity of the Frontal Cortex and Limbic System to Emotional Stimuli: An fMRI Study Completed NCT00456820 Phase 4 Wellbutrin XL
18 Statin Therapy is Associated With Low Testosterone and Sexual Function in Men With Type 2 Diabetes Completed NCT02612714 Phase 4 Rosuvastatin
19 The Effects of Diet-induced Weight Loss on Metabolic and Inflammatory Profile, Endothelial, Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554865 Phase 4
20 The Effects of Lifestyle-modification Induced Weight Loss on Metabolic and Inflammatory Profile, Endothelial, Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554735 Phase 4
21 A Pilot Study of the Efficacy and Tolerability of Bupropion Extended Release (Wellbutrin XL) for the Treatment of Major Depressive Disorder in Women With Breast Cancer Completed NCT00234195 Phase 4 bupropion extended release (Wellbutrin XL)
22 Aripiprazole for the Treatment of Schizophrenia With Co-Morbid Social Anxiety Completed NCT00177008 Phase 4 Aripiprazole
23 A Randomized, Double Blind, Parallel Group Study of Vardenafil Flexible Dose Versus Placebo in Males With Erectile Dysfunction and Their Female Partners Sexual Quality of Life. PARTNER II Completed NCT00377793 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
24 Evaluation of the Effects of Monopolar Transurethral Resection Versus Bipolar Transurethral Resection and Holmium Laser Enucleation of the Prostate on Urinary and Sexual Function; a Prospective Comparative Study. Completed NCT01810068 Phase 4
25 Study of the Effects of Tribulus Terrestris on Sexuality in Postmenopausal Women Completed NCT01407445 Phase 4 Placebo;Tribulus terrestris
26 Effects of Continuous Subcutaneous Insulin Infusion (CSII) on Erectile Dysfunction in T2DM Patients: A Prospective, Exploratory, Controlled Trial Completed NCT01468519 Phase 4 Insulin;Insulin
27 An Integrated Approach With Vardenafil Orodispersible and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
28 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
29 The Effect of Armodafinil (Nuvigil) on Fatigue and Quality of Life in Peri- and Postmenopausal Women Completed NCT01460628 Phase 4 Armodafinil
30 Agomelatine Treatment of Major Depressive Episodes in the Course of Schizophrenic Psychoses (AGOPSYCH) Completed NCT01822418 Phase 4 agomelatine
31 Effect of Serotonin Reuptake Inhibitors on Gonadal Steroid Hormones Completed NCT00611975 Phase 4 Fluoxetine;Bupropion
32 A Study of Sertraline to Prevent PTSD Completed NCT00182078 Phase 4 Placebo;Sertraline
33 The Impact of Different Hormone Therapy Regimens on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder Recruiting NCT01822288 Phase 4 Tibolone;Estradiol & medroxyprogesterone acetate
34 BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function (BETAMI) Recruiting NCT03646357 Phase 4 Betablocker
35 Treating Where it Hurts: A Randomized Blinded Clinical Trial of Local Estrogen to the Vulvar Vestibule for Dyspareunia in Postmenopausal Women Active, not recruiting NCT03240081 Phase 4 50mcg estradiol cream;100mcg estradiol cream
36 Post-Prostatectomy Erectile Dysfunction: Effect of Hyperbaric Oxygen Therapy Active, not recruiting NCT00906269 Phase 4 Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
37 Sexual Dysfunction in Gynecologic Oncology Patients Not yet recruiting NCT03801031 Phase 4 Lidocaine Topical;Placebo
38 Improving Patient-Important Outcomes With Testosterone Replacement in Hypogonadal Men With a Prior History of Cancer Not yet recruiting NCT04049331 Phase 4 Testosterone cypionate 125 mg/week
39 A Multicenter, Randomized, Double-blind, Placebo-controlled Study: Evaluation of the Efficacy and Safety of Agomelatine in the Treatment of Sleep Disorders and Depression in Patients With Parkinson's Disease Not yet recruiting NCT03977441 Phase 4 Agomelatine or PIacebo
40 Initiative to Minimize Disparities in Postoperative Prostate Cancer Care Not yet recruiting NCT03755492 Phase 4 Tadalafil Oral Tablet
41 Ospemifene Versus Conjugated Estrogens in the Treatment of Postmenopausal Sexual Dysfunction Terminated NCT03018106 Phase 4 Ospemifene;Vaginal conjugated estrogens
42 Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction Terminated NCT00398632 Phase 4 Duloxetine
43 A Randomized, Double-Blind, Active Controlled Clinical Trial of Switching to Vilazodone for Antidepressant-Associated Sexual Dysfunction Terminated NCT01856127 Phase 4 Vilazodone;Sertraline
44 An Open-label Study to Determine the Effect of Switching to Aripiprazole Once Monthly for Subjects With Schizophrenia Experiencing Worsening Sexual Dysfunction With Invega Sustenna or Risperdal Consta Terminated NCT02472652 Phase 4 Abilify Maintena
45 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
46 Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis Terminated NCT00854750 Phase 4 ACTHAR;ACTHAR;ACTHAR;ACTHAR
47 THE INFLUENCE OF COGNITIVE BEHAVIORAL THERAPY IN SEXUAL DYSFUNCTION FEMALE: Randomized Clinical Trial Unknown status NCT02613546 Phase 2, Phase 3
48 Self-care Programs in Oncology: a Guided Internet-delivered Individually-tailored Acceptance and Commitment Therapy (ACT)-Influenced Cognitive Behavioural Intervention to Improve Psychosocial Outcomes in Breast Cancer Survivors Unknown status NCT03275727 Phase 2, Phase 3
49 The Role of 5-Alpha Reductase in Mediating Testosterone Actions Unknown status NCT00070733 Phase 3 testosterone enanthate;duastride
50 Evaluate the Long-term (3 Months) Efficacy of L-threo DOPS (DroxiDopa) on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With Multiple System Atrophy (MSA). Comparative Study Versus Placebo Unknown status NCT02071459 Phase 2, Phase 3 L-Threo DOPS;placebo

Search NIH Clinical Center for Sexual Disorder

Genetic Tests for Sexual Disorder

Anatomical Context for Sexual Disorder

MalaCards organs/tissues related to Sexual Disorder:

Prostate, Breast, Spinal Cord, Heart, Brain, Testes, Kidney

Publications for Sexual Disorder

Articles related to Sexual Disorder:

(show top 50) (show all 9746)
# Title Authors PMID Year
The effects of aerobic physical exercises on body image among women with polycystic ovary syndrome. 61
31735408 2020
Management of Urologic and Sexual Dysfunction in Parkinson Disease. 61
31733703 2020
Erectile dysfunction and mining-related jobs: an explorative study in Lubumbashi, Democratic Republic of Congo. 61
31662423 2020
Sexual dysfunction in tramadol hydrochloride use disorder male patients: a case-control study. 61
31567513 2020
Sexual dysfunction in patients with neuromyelitis optica spectrum disorder. 61
31726377 2020
Pelvic Floor Muscle Parameters Affect Sexual Function After 8 Weeks of Transcutaneous Electrical Stimulation in Women with Stress Urinary Incontinence. 61
31563553 2019
How Is the Sexual Function of Premenopausal Chinese Women Without Hyperlipidemia? 61
31837966 2019
Patient-Centered Outcomes After Modified Vestibulectomy. 61
31809431 2019
Men's experiences of surviving testicular cancer: an integrated literature review. 61
31823122 2019
Ten-Year Systematic Review of Sexuality and Breastfeeding in Medicine, Psychology, and Gender Studies. 61
31697902 2019
Chronic Spinal Cord Injury Reduces Gastrin-Releasing Peptide in the Spinal Ejaculation Generator in Male Rats. 61
31111794 2019
A Paradigmatic Case of Postselective Serotonin Reuptake Inhibitors Sexual Dysfunction or Withdrawal After Discontinuation of Selective Serotonin Reuptake Inhibitors? 61
31834096 2019
Protective effect of ethanolic extract of Hygrophila auriculata seeds in cyproterone acetate-induced sexual dysfunction in male albino rats. 61
31815317 2019
Investigating the effect of a symposium on sexual health care in prostate cancer among Dutch healthcare professionals. 61
31342585 2019
Survey of Sexual Function and Pornography. 61
31132108 2019
Sexual function after cancer: paying the price of survivorship. 61
31090466 2019
Hypothalamic-Pituitary Disorders in Childhood Cancer Survivors: Prevalence, Risk Factors and Long-Term Health Outcomes. 61
31373627 2019
An updated meta-analysis of prostatic arterial embolization versus transurethral resection of the prostate in the treatment of benign prostatic hyperplasia. 61
31813027 2019
Adult-onset neuronal intranuclear inclusion disease presenting with typical MRI changes. 61
31749292 2019
Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. 61
31792367 2019
Mindfulness-based cognitive therapy for sexuality (MBCT-S) improves sexual functioning and intimacy among older women with epilepsy: A multicenter randomized controlled trial. 61
31759295 2019
Management of Antipsychotic-Related Sexual Dysfunction: Systematic Review. 61
31585803 2019
[Prevalence and characteristics of sexual dysfunction among Moroccan patients consulting for a first depressive episode]. 61
31495551 2019
Accuracy of the Defining Characteristics of the Sexual Dysfunction Nursing Diagnosis in Women with Breast Cancer. 61
31797558 2019
Prevalence of sexual dysfunction and related factors among diabetes mellitus patients in Southwest Ethiopia. 61
31852461 2019
The Incidence of Sexual Dysfunction in Patients With Irritable Bowel Syndrome. 61
31604682 2019
Pelvic Floor and Sexual Dysfunction After Vaginal Birth With Episiotomy in Vietnamese Women. 61
31607584 2019
Sexual dysfunction: an often overlooked concern for people with inflammatory arthritis. 61
31657976 2019
Prevalence and risk factors for sexual dysfunction in reproductive-aged married women: A cross-sectional epidemiological study. 61
31854497 2019
A Randomized Study Comparing Video-Based Mindfulness-Based Cognitive Therapy With Video-Based Traditional Cognitive Behavioral Therapy in a Sample of Women Struggling to Achieve Orgasm. 61
31818723 2019
Compliance With Fluoxetine Use in Men With Primary Premature Ejaculation. 61
31735615 2019
Urinary Tract Infections after Combat-Related Genitourinary Trauma. 61
31112074 2019
Postpartum Female Sexual Function: Risk Factors for Postpartum Sexual Dysfunction. 61
31837965 2019
Sexual Dysfunction in Menopausal Women. 61
31371259 2019
Sexual Function, Quality of Life, and Experiences of Women with Ovarian Cancer: A Mixed-Methods Study. 61
31501030 2019
Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art. 61
31805761 2019
Pelvic floor physical therapy in the treatment of pelvic floor dysfunction in women. 61
31609735 2019
Coital resumption after delivery among OASIS patients: differences between instrumental and spontaneous delivery. 61
31810460 2019
Comparison of sexual function in Tunisian women with rheumatoid arthritis and healthy controls. 61
31392560 2019
Psychological and Sexual Consequences of Psoriasis Vulgaris on Patients and Their Partners. 61
31542353 2019
How Does Childhood Trauma Impact Women's Sexual Desire? Role of Depression, Stress, and Cortisol. 61
31809591 2019
Association Between Pelvic Floor Muscle Strength and Sexual Function in Postmenopausal Women. 61
31680007 2019
Sexual quality of life after the treatment of gynecologic cancer: what women want. 61
30941579 2019
Contraceptive use and sexual function: a comparison of Italian female medical students and women attending family planning services. 61
31545112 2019
The importance of and satisfaction with sex life among breast cancer survivors in comparison with healthy female controls and women with mental depression or arterial hypertension: results from the Finnish nationwide HeSSup cohort study. 61
31836939 2019
The Oncology and Sexuality, Intimacy, and Survivorship Program Model: An Integrated, Multi-disciplinary Model of Sexual Health Care within Oncology. 61
31797198 2019
Patient interest in the Lowdown on Down There: attendance at a vulvovaginal and sexual health workshop post-cancer treatment. 61
31845008 2019
Do we need better information to advise women with stress incontinence on their choice of surgery? Report from the ICI-RS 2018. 61
31821636 2019
A longitudinal qualitative evaluation of patient perspectives of adverse events after pelvic reconstructive surgery. 61
31187179 2019
TaTME: analysis of the evacuatory outcomes and EUS anal sphincter. 61
30888248 2019

Variations for Sexual Disorder

Expression for Sexual Disorder

Search GEO for disease gene expression data for Sexual Disorder.

Pathways for Sexual Disorder

Pathways related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
8 11.51 RHOA NOS3 INS
Show member pathways
11.41 NOS3 NOS1 ALDH7A1
10 11.33 RHOA PRL INS
Show member pathways
11.23 PDE5A NOS3 NOS1
13 10.94 HTR2C HTR2A HTR1A
14 10.73 PRL INS HTR2C
15 10.4 NOS3 NOS1
16 9.91 PDE5A NOS3 NOS1

GO Terms for Sexual Disorder

Cellular components related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 9.33 NOS3 NOS1 HTR2A
2 septin complex GO:0031105 9.13 SEPTIN8 SEPTIN6 SEPTIN3
3 septin ring GO:0005940 8.8 SEPTIN8 SEPTIN6 SEPTIN3

Biological processes related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.15 PRL PDE5A PDE4A OXT INS HTR2C
2 G protein-coupled receptor signaling pathway GO:0007186 10.01 RHOA PDE4A OXT INS HTR2C HTR2A
3 positive regulation of cell proliferation GO:0008284 9.99 PRL INS HTR2A HTR1A ADRA1D
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.73 HTR2C HTR2A HTR1A
5 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.72 HTR2C HTR2A ADRA1D
6 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.61 RHOA INS
7 positive regulation of vasoconstriction GO:0045907 9.61 RHOA HTR2A ADRA1D
8 negative regulation of calcium ion transport GO:0051926 9.6 NOS3 NOS1
9 nitric oxide biosynthetic process GO:0006809 9.58 NOS3 NOS1
10 sleep GO:0030431 9.58 OXT HTR2A
11 positive regulation of guanylate cyclase activity GO:0031284 9.57 NOS3 NOS1
12 negative regulation of hydrolase activity GO:0051346 9.54 NOS3 NOS1
13 negative regulation of blood pressure GO:0045776 9.54 OXT NOS3 NOS1
14 arginine catabolic process GO:0006527 9.52 NOS3 NOS1
15 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.51 RHOA NOS3
16 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.48 HTR2C HTR2A
17 regulation of neurological system process GO:0031644 9.46 NOS3 HTR2C
18 cytoskeleton-dependent cytokinesis GO:0061640 9.43 SEPTIN8 SEPTIN6 SEPTIN3
19 behavior GO:0007610 9.33 HTR2C HTR2A HTR1A
20 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.32 HTR2C HTR2A
21 negative regulation of potassium ion transport GO:0043267 9.13 NOS3 NOS1 HTR2A
22 serotonin receptor signaling pathway GO:0007210 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 SHBG SEPTIN8 SEPTIN6 SEPTIN3 RHOA PRL
2 GTP binding GO:0005525 9.85 SEPTIN8 SEPTIN6 SEPTIN3 RHOA EHD4
3 drug binding GO:0008144 9.67 HTR2C HTR2A ACE
4 FMN binding GO:0010181 9.52 NOS3 NOS1
5 arginine binding GO:0034618 9.51 NOS3 NOS1
6 neurotransmitter receptor activity GO:0030594 9.5 HTR2C HTR2A HTR1A
7 NADPH-hemoprotein reductase activity GO:0003958 9.48 NOS3 NOS1
8 G protein-coupled serotonin receptor activity GO:0004993 9.43 HTR2C HTR2A HTR1A
9 cadmium ion binding GO:0046870 9.4 NOS3 NOS1
10 tetrahydrobiopterin binding GO:0034617 9.37 NOS3 NOS1
11 nitric-oxide synthase activity GO:0004517 9.16 NOS3 NOS1
12 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
13 serotonin binding GO:0051378 8.8 HTR2C HTR2A HTR1A

Sources for Sexual Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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