Aliases & Classifications for Sexual Disorder

MalaCards integrated aliases for Sexual Disorder:

Name: Sexual Disorder 12 15
Sexual Dysfunction 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060043
UMLS 73 C0549622

Summaries for Sexual Disorder

Disease Ontology : 12 A disease of mental health that involves the impairment in normal sexual functioning.

MalaCards based summary : Sexual Disorder, also known as sexual dysfunction, is related to gynecomastia and jejunoileitis, and has symptoms including increased libido An important gene associated with Sexual Disorder is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Vascular smooth muscle contraction and Prolactin Signaling Pathway. The drugs Fenofibrate and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and bone, and related phenotypes are cardiovascular system and nervous system

Related Diseases for Sexual Disorder

Diseases related to Sexual Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 30.0 KLK3 PRL SHBG
2 jejunoileitis 10.6 ALDH7A1 NOS1 NOS3
3 hypoactive sexual desire disorder 10.6 HTR1A SHBG
4 prostatic adenoma 10.6 KLK3 SHBG
5 psychosexual disorder 10.6 HTR1A PDE5A SHBG
6 tetrahydrobiopterin deficiency 10.5 NOS1 NOS3 PRL
7 androgenic alopecia 10.5 KLK3 PRL SHBG
8 persistent fetal circulation syndrome 10.5 EDN1 NOS3 PDE5A
9 acute chest syndrome 10.5 EDN1 NOS1 NOS3
10 varicocele 10.5 NOS3 PRL SHBG
11 arteritic anterior ischemic optic neuropathy 10.4 ACE NOS3 PDE5A
12 renal artery disease 10.4 ACE NOS3
13 breast disease 10.4 KLK3 PRL SHBG
14 angina pectoris 10.3 ACE EDN1 NOS3
15 aortic coarctation 10.3 ACE EDN1 NOS3
16 acute mountain sickness 10.3 ACE EDN1 NOS3
17 limb ischemia 10.2 ACE EDN1 NOS3
18 hypertension, diastolic 10.2 ACE KCNMA1
19 pulmonary edema 10.2 ACE EDN1 NOS3
20 sleep apnea 10.2 ACE EDN1 NOS3
21 arteries, anomalies of 10.2 ACE EDN1 NOS3
22 coronary artery vasospasm 10.2 EDN1 NOS3
23 urinary system disease 10.1 ACE EDN1 KLK3
24 psychotic disorder 10.1 HTR1A NOS1 PRL
25 acquired metabolic disease 10.1 ACE NOS3 PRL SHBG
26 ischemic optic neuropathy 10.1 ACE EDN1 NOS3 PDE5A
27 nonarteritic anterior ischemic optic neuropathy 10.1 ACE EDN1 NOS3 PDE5A
28 renovascular hypertension 10.1 ACE EDN1 NOS1 NOS3
29 postmenopausal atrophic vaginitis 9.9 OXT SHBG
30 coronary artery anomaly 9.9 ACE EDN1 NOS3 PDE5A
31 vasculogenic impotence 9.9 ACE ALDH7A1 NOS3 PDE4A PDE5A
32 pedophilia 9.9 OXT PRL
33 premenstrual tension 9.8 OXT PRL SHBG
34 female reproductive system disease 9.7 OXT PRL SHBG
35 disease of mental health 9.7 HTR1A OXT PDE5A
36 prostatitis 9.7
37 reproductive system disease 9.5 KLK3 OXT PRL SHBG
38 prostate cancer 9.5
39 prostatic hypertrophy 9.5
40 social phobia 9.5
41 fetishism 9.5
42 premature ejaculation 9.5
43 fibromyalgia 9.5
44 autosomal dominant polycystic kidney disease 9.5 ACE EDN1 NOS3
45 obsessive-compulsive disorder 9.3 HTR1A OXT PRL
46 pulmonary hypertension 9.0 ACE EDN1 NOS3 PDE4A PDE5A RHOA
47 impotence 8.0 ALDH7A1 EDN1 KCNMA1 KLK3 NOS1 NOS3

Graphical network of the top 20 diseases related to Sexual Disorder:



Diseases related to Sexual Disorder

Symptoms & Phenotypes for Sexual Disorder

UMLS symptoms related to Sexual Disorder:


increased libido

MGI Mouse Phenotypes related to Sexual Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 ACE EDN1 HTR1A KCNMA1 NOS1 NOS3
2 nervous system MP:0003631 9.4 SEPT3 SEPT8 EDN1 HTR1A KCNMA1 NOS1

Drugs & Therapeutics for Sexual Disorder

Drugs for Sexual Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 488)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fenofibrate Approved Phase 4 49562-28-9 3339
2
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
3
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
4
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
5
Metoprolol Approved, Investigational Phase 4,Not Applicable 37350-58-6, 51384-51-1 4171
6
Aripiprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 129722-12-9 60795
7
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
8
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
9
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-18-4 6010
10
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-22-0 6013
11
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 315-37-7 9416
12
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 5949-44-0
13
Nebivolol Approved, Investigational Phase 4,Not Applicable 152520-56-4, 99200-09-6, 118457-14-0 71301
14
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 171596-29-5 110635
15
Bupivacaine Approved, Investigational Phase 4,Phase 1 2180-92-9, 38396-39-3 2474
16
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
17
Drospirenone Approved Phase 4 67392-87-4 68873
18
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
19 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
20
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 1 57-63-6 5991
21
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
22
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
23
Udenafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 268203-93-6 6918523
24
Alfuzosin Approved, Investigational Phase 4,Phase 3,Not Applicable 81403-80-7 2092
25
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068 160954
26
Tamoxifen Approved Phase 4,Phase 2 10540-29-1 2733526
27
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
28
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
29
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 745-65-3 149351 5280723
30
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
31
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
32
Zinc Approved, Investigational Phase 4 7440-66-6 23994
33
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
34
Vortioxetine Approved, Investigational Phase 4,Phase 3 508233-74-7 9966051
35
Bupropion Approved Phase 4,Phase 2,Phase 3,Phase 1 34841-39-9, 34911-55-2 444
36
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
37
Curcumin Approved, Investigational Phase 4,Not Applicable 458-37-7 969516
38
Yohimbine Approved, Investigational, Vet_approved Phase 4,Phase 1 146-48-5 8969
39
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
40
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
41
Loperamide Approved Phase 4,Early Phase 1 53179-11-6 3955
42
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
43
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
44
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
45
Tibolone Approved, Investigational Phase 4,Phase 3 5630-53-5
46
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
47 Lynestrenol Approved, Investigational Phase 4 52-76-6
48
Estrone Approved Phase 4,Phase 1 53-16-7 5870
49
Sertraline Approved Phase 4,Phase 2 79617-96-2 68617
50
Rosiglitazone Approved, Investigational Phase 4,Phase 1 122320-73-4 77999

Interventional clinical trials:

(show top 50) (show all 906)
# Name Status NCT ID Phase Drugs
1 Treatment of Hyperlipidemia and Sexual Dysfunction Unknown status NCT00923676 Phase 4 fenofibrate;Rosuvastatin;fenofibrate + rosuvastatin
2 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4 Felodipine add Irbesartan;Felodipine add Metoprolol
3 Clinical Study to Assess the Influence of a Saw Palmetto Preparation in Patients With Benign Prostatic Hyperplasia (BPH) and Sexual Dysfunctions Unknown status NCT01021267 Phase 4 Saw palmetto berry extract
4 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
5 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
6 Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males Unknown status NCT00313898 Phase 4 sildenafil (viagra)
7 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
8 Testosterone Patch's Effects on the Cardiovascular System and Libido Unknown status NCT01208038 Phase 4 Intrinsa Transdermal testosterone patch
9 Nebivolol Effects on Endothelial Function and Erectile Function Unknown status NCT01885988 Phase 4 Nebivolol;Sugar Pill
10 Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment Unknown status NCT01364701 Phase 4 Sildenafil 100 mg;Tadalafil 20 mg;Combination half of maximal dose for sildenafil & tadalafil
11 Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate Unknown status NCT00555087 Phase 4 Testosterone Undecanoate and/or PDE-5
12 Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i Unknown status NCT00498680 Phase 4 Sildenafil, Vardenafil;Sildenafil;Vardenafil;Sildenafil & Vardenafil
13 Trigger Point Injections and Pelvic Rehabilitation for the Treatment of Pelvic Floor Myalgia and Sexual Pain Unknown status NCT02022722 Phase 4 Trigger Point Injections Triamcinolone Acetonide, Bupivacaine Hydrochloride
14 Effect of Vardenafil on Erectile Dysfunction and Portal Hemodynamics in Patients With Liver Cirrhosis Unknown status NCT02344823 Phase 4 Vardenafil;Placebo intake once daily
15 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
16 Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer Unknown status NCT00906269 Phase 4 Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
17 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
18 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
19 Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo Completed NCT00334048 Phase 4 Ropinirole (Requip)
20 Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction Completed NCT00174850 Phase 4 Gaitril
21 Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women Completed NCT00375297 Phase 4 sildenafil
22 Statin Lowering Testosterone and Sexual Function Completed NCT02612714 Phase 4 Rosuvastatin
23 Levitra (Vardenafil, BAY38-9456) Partner Satisfaction Study II Completed NCT00377793 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
24 Daily Tadalafil on Body Fat and Lean Mass Completed NCT02554045 Phase 4 Tadalafil;Placebo
25 Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder Completed NCT01971099 Phase 4 tribulus terrestris
26 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris
27 SAMBA: Sexuality And Management of Benign Prostatic Hyperplasia With Alfuzosin Completed NCT00486785 Phase 4 Alfuzosin
28 Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients Completed NCT01468519 Phase 4 Insulin;Insulin
29 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
30 Effect of Vortioxetine, Paroxetine, and Placebo on Sexual Functioning in Healthy Volunteers Completed NCT02932904 Phase 4 Vortioxetine;Paroxetine;Placebo
31 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
32 Sexual Functioning Study With Antidepressants Completed NCT00316160 Phase 4 Bupropion Hydrochloride Extended-release;Extended-release Venlafaxine
33 Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men Completed NCT01642576 Phase 4
34 Effects of Diet-induced Weight Loss in Obese Men Completed NCT01554865 Phase 4
35 Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men Completed NCT01554735 Phase 4
36 Wellbutrin XL Effects on SSRIs Induced Changes Completed NCT00456820 Phase 4 Wellbutrin XL
37 Effects of Tribulus Terrestris on Sexual Function in Post-menopausal Women Completed NCT01407445 Phase 4 Placebo;Tribulus terrestris
38 Vardenafil and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
39 The Efficacy and Safety of New Herbal Formula (KBMSI-2) in the Treatment of Erectile Dysfunction Completed NCT02413099 Phase 4 KBMSI-2
40 A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction Completed NCT02224846 Phase 4 Tadalafil
41 Study Evaluating the Effects of Avanafil on Semen Parameters Completed NCT01768676 Phase 4 avanafil;Placebo
42 Research Evaluating a PDE5 Inhibitor for Erectile Dysfunction Completed NCT01698684 Phase 4 Placebo;Avanafil 100 mg;Avanafil 200 mg
43 A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China Completed NCT01352507 Phase 4 Tadalafil;Sildenafil
44 Efficacy and Safety of Lodenafil Carbonate in the Treatment of Erectile Dysfunction in Patients With Diabetes. Completed NCT01180283 Phase 4 lodenafil carbonate
45 Satisfaction, Confidence and Naturalness in Men With Psychogenic Erectile Dysfunction (ED) Completed NCT01153204 Phase 4 Sildenafil citrate
46 A Study in Erectile Dysfunction Completed NCT01130532 Phase 4 Tadalafil;Placebo
47 A Study in Patients With Erectile Dysfunction Completed NCT01122264 Phase 4 Tadalafil;Sildenafil Citrate
48 A Study of Tadalafil After Radical Prostatectomy Completed NCT01026818 Phase 4 Tadalafil;Placebo
49 Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine Completed NCT00975325 Phase 4 Yohimbine;Yohimbine
50 A Study in Erectile Dysfunction Completed NCT00833638 Phase 4 Placebo;Tadalafil

Search NIH Clinical Center for Sexual Disorder

Genetic Tests for Sexual Disorder

Anatomical Context for Sexual Disorder

MalaCards organs/tissues related to Sexual Disorder:

41
Prostate, Spinal Cord, Bone, Liver, Testes, Brain, Endothelial

Publications for Sexual Disorder

Articles related to Sexual Disorder:

(show all 22)
# Title Authors Year
1
Technological change and sexual disorder. ( 27028747 )
2016
2
Hebephilia as a sexual disorder. ( 25723776 )
2015
3
[Urinary and sexual disorders following localised prostate cancer management]. ( 21220229 )
2010
4
Sexual disorder improvement: a target or a way in treatment of fibromyalgia. A case report and brief review. ( 19802653 )
2010
5
Drug treatment of paraphilic and nonparaphilic sexual disorders. ( 19243704 )
2009
6
Male sexuality and psychological trauma: soldiers and sexual disorder in World War I and Weimar Germany. ( 19260157 )
2008
7
Finasteride: new indication. Benign prostatic hypertrophy: sexual disorders. ( 17724838 )
2007
8
Treatment of paraphilic sexual disorder: the use of topiramate in fetishism. ( 16687996 )
2006
9
Comorbidity between social phobia and premature ejaculation: study on 242 males affected by sexual disorders. ( 16418108 )
2006
10
[The significance of the androgen-estrogen ratios in the clinical picture of sexual disorders in men]. ( 10878975 )
2000
11
Female hypoactive sexual disorder: case studies of physiologic androgen replacement. ( 10407790 )
1999
12
SEIZURE RELATED SEXUAL DISORDER. ( 28775613 )
1999
13
Pharmacological era in the treatment of sexual disorder. ( 9611685 )
1998
14
Gynecomastia and sexual disorders after the administration of omeprazole. ( 7771409 )
1995
15
Sexual disorders in Huntington's disease. ( 8044036 )
1994
16
Neurotransmitter, opiodergic system, steroid-hormone interaction and involvement in the replacement therapy of sexual disorders. ( 1979499 )
1990
17
Interruption in the maintenance of compulsive sexual disorder: two case studies. ( 3219064 )
1988
18
Treatment of sexual disorder: a prophylaxis for major pathology? ( 3820157 )
1987
19
Dyspareunia; a symptom of sexual disorder in the female. ( 1043847 )
1976
20
A note on avoidance conditioning techniques in sexual disorder. ( 5853245 )
1965
21
SEXUAL DISORDER IN POSTTRAUMATIC AND POSTCONCUSSIONAL STATES. ( 14128413 )
1964
22
Sexual disorder in 'mepacrine psychoses'. ( 15412077 )
1950

Variations for Sexual Disorder

Expression for Sexual Disorder

Search GEO for disease gene expression data for Sexual Disorder.

Pathways for Sexual Disorder

Pathways related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 KCNMA1 NOS3 OXT PDE5A RHOA ROCK2
2
Show member pathways
12.26 NOS3 PRL RHOA ROCK2
3
Show member pathways
12.04 HTR1A PDE4A RHOA ROCK2
4
Show member pathways
11.98 KCNMA1 NOS1 NOS3 PDE5A
5 11.81 NOS3 RHOA ROCK2
6 11.79 NOS1 RHOA ROCK2
7 11.77 NOS3 RHOA ROCK2
8 11.63 KLK3 RHOA ROCK2
9 11.49 NOS1 RHOA ROCK2
10 11.33 RHOA SEPT3 SEPT6 SEPT8
11
Show member pathways
11.3 ALDH7A1 NOS1 NOS3
12 10.91 NOS3 RHOA ROCK2
13
Show member pathways
10.55 KCNMA1 NOS1 NOS3 PDE5A
14 10.36 NOS1 NOS3
15 10.25 NOS1 NOS3 PDE5A

GO Terms for Sexual Disorder

Cellular components related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.91 NOS1 NOS3 RHOA ROCK2 SEPT3 SEPT6
2 caveola GO:0005901 9.5 KCNMA1 NOS1 NOS3
3 septin filament array GO:0032160 9.43 SEPT3 SEPT6 SEPT8
4 septin complex GO:0031105 9.33 SEPT3 SEPT6 SEPT8
5 septin ring GO:0005940 9.13 SEPT3 SEPT6 SEPT8
6 cell division site GO:0032153 8.92 RHOA SEPT3 SEPT6 SEPT8

Biological processes related to Sexual Disorder according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.74 KLK3 PRL ROCK2
2 regulation of blood pressure GO:0008217 9.67 ACE EDN1 NOS3
3 response to hypoxia GO:0001666 9.62 EDN1 KCNMA1 NOS1 RHOA
4 regulation of focal adhesion assembly GO:0051893 9.6 RHOA ROCK2
5 regulation of sodium ion transport GO:0002028 9.59 NOS1 NOS3
6 nitric oxide mediated signal transduction GO:0007263 9.58 NOS1 NOS3
7 vasoconstriction GO:0042310 9.58 EDN1 HTR1A
8 mitotic cytokinesis GO:0000281 9.58 SEPT3 SEPT6 SEPT8
9 positive regulation of renal sodium excretion GO:0035815 9.56 EDN1 OXT
10 negative regulation of calcium ion transport GO:0051926 9.55 NOS1 NOS3
11 nitric oxide biosynthetic process GO:0006809 9.54 NOS1 NOS3
12 cellular protein localization GO:0034613 9.54 SEPT3 SEPT6 SEPT8
13 positive regulation of guanylate cyclase activity GO:0031284 9.52 NOS1 NOS3
14 negative regulation of potassium ion transport GO:0043267 9.51 NOS1 NOS3
15 arginine catabolic process GO:0006527 9.48 NOS1 NOS3
16 negative regulation of hydrolase activity GO:0051346 9.46 NOS1 NOS3
17 positive regulation of prostaglandin secretion GO:0032308 9.43 EDN1 OXT
18 negative regulation of blood pressure GO:0045776 9.43 NOS1 NOS3 OXT
19 regulation of blood vessel size GO:0050880 9.33 EDN1 NOS1 NOS3
20 septin ring assembly GO:0000921 9.13 SEPT3 SEPT6 SEPT8
21 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.8 EDN1 NOS3 RHOA

Molecular functions related to Sexual Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activity GO:0003924 9.73 RHOA SEPT3 SEPT6 SEPT8
2 hormone activity GO:0005179 9.63 EDN1 OXT PRL
3 protein-containing complex scaffold activity GO:0032947 9.5 SEPT3 SEPT6 SEPT8
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.48 NOS1 NOS3
5 FMN binding GO:0010181 9.4 NOS1 NOS3
6 arginine binding GO:0034618 9.37 NOS1 NOS3
7 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS1 NOS3
8 cadmium ion binding GO:0046870 9.16 NOS1 NOS3
9 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS3
10 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Sexual Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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