MCID: SXL001
MIFTS: 30

Sexual Sadism

Categories: Mental diseases
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Aliases & Classifications for Sexual Sadism

MalaCards integrated aliases for Sexual Sadism:

Name: Sexual Sadism 11 14 71
Sadism 43 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:10817
ICD9CM 34 302.84
MeSH 43 D012448
NCIt 49 C94358
SNOMED-CT 68 59394009
UMLS 71 C0036039 C0036913

Summaries for Sexual Sadism

MalaCards based summary: Sexual Sadism, also known as sadism, is related to voyeurism and brunner syndrome. An important gene associated with Sexual Sadism is TTF2 (Transcription Termination Factor 2), and among its related pathways/superpathways are Signal Transduction and Tyrosine metabolism p.1 (dopamine). Affiliated tissues include brain, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Sexual Sadism

Diseases related to Sexual Sadism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 voyeurism 30.5 OXT MAOA
2 brunner syndrome 30.3 TTF2 MAOA COMT
3 pedophilia 30.2 PRL OXT MAOA
4 antisocial personality disorder 29.5 TTF2 PRL OXTR OXT MAOA DRD2
5 personality disorder 29.5 PRL OXTR MAOA DRD2 CRH COMT
6 borderline personality disorder 29.0 PRL OXTR MAOA DRD2 CRH COMT
7 substance abuse 28.8 PRL POMC OXT MAOA DRD2 CRH
8 cortisone reductase deficiency 2 10.3 POMC OXT
9 schizoid personality disorder 10.3 DRD2 CPZ
10 pyromania 10.3 MAOA DRD2
11 prosopagnosia 10.3 OXTR OXT
12 barbiturate abuse 10.3 POMC MAOA
13 narcissistic personality disorder 10.2 TTF2 OXT MAOA
14 polysubstance abuse 10.2 DRD2 COMT
15 paraphilia disorder 10.2 OXT MAOA DRD2
16 sexual masochism 10.2
17 fetishism 10.2
18 hypochondriasis 10.2 POMC OXT MAOA
19 atypical autism 10.2 OXTR OXT
20 tardive dyskinesia 10.2 DRD2 COMT
21 cyclothymic disorder 10.2 DRD2 COMT
22 dissociative disorder 10.2 OXT COMT
23 drug psychosis 10.2 DRD2 COMT
24 drug-induced mental disorder 10.2 DRD2 COMT
25 nephrogenic syndrome of inappropriate antidiuresis 10.2 OXTR OXT
26 vaginal adenoma 10.2 OXT HSPA4
27 pure autonomic failure 10.1 PDE5A MAOA
28 lipoid proteinosis of urbach and wiethe 10.1 OXTR OXT
29 schizotypal personality disorder 10.1 DRD2 CPZ COMT
30 tic disorder 10.1 MAOA DRD2 COMT
31 hepatic encephalopathy 10.1 PDE5A MAOA DRD2
32 substance-induced psychosis 10.1 DRD2 COMT
33 kluver-bucy syndrome 10.1 OXT CRH
34 delusional disorder 10.1 DRD2 COMT
35 diabetes insipidus, neurohypophyseal 10.1 POMC OXT
36 kleptomania 10.1 MAOA DRD2 COMT
37 premature ejaculation 10.1 PDE5A OXT COMT
38 pathological gambling 10.1 MAOA DRD2 COMT
39 premature ovarian failure 7 10.1 POMC CRH
40 impulse control disorder 10.1 MAOA DRD2 COMT
41 waterhouse-friderichsen syndrome 10.1 POMC CRH
42 heroin dependence 10.1 MAOA DRD2 COMT
43 mediastinal lipomatosis 10.1 POMC CRH
44 asperger syndrome 10.1 OXTR OXT COMT
45 neuronopathy, distal hereditary motor, type iic 10.1 HSPB3 HSPB2
46 pervasive developmental disorder 10.1 OXTR OXT DRD2
47 transvestism 10.1
48 ritter's disease 10.1
49 gilles de la tourette syndrome 10.0 MAOA DRD2 COMT
50 somatization disorder 10.0 POMC OXT CRH

Graphical network of the top 20 diseases related to Sexual Sadism:



Diseases related to Sexual Sadism

Symptoms & Phenotypes for Sexual Sadism

MGI Mouse Phenotypes related to Sexual Sadism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 COMT CRH DRD2 FITM2 HSPB1 HSPB3
2 liver/biliary system MP:0005370 9.91 CRH DRD2 FITM2 PDE5A PDGFB POMC
3 endocrine/exocrine gland MP:0005379 9.91 COMT CRH DRD2 HSPA4 MFGE8 OXT
4 cardiovascular system MP:0005385 9.85 COMT DRD2 FITM2 HSPB1 HSPB2 MAOA
5 immune system MP:0005387 9.7 COMT CRH DRD2 FITM2 HSPB1 MFGE8
6 integument MP:0010771 9.28 CRH DRD2 FITM2 MFGE8 OXT OXTR

Drugs & Therapeutics for Sexual Sadism

Search Clinical Trials, NIH Clinical Center for Sexual Sadism

Cochrane evidence based reviews: sadism

Genetic Tests for Sexual Sadism

Anatomical Context for Sexual Sadism

Organs/tissues related to Sexual Sadism:

MalaCards : Brain

Publications for Sexual Sadism

Articles related to Sexual Sadism:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Sadism and psychopathy in violent and sexually violent offenders. 53 62
10212024 1999
2
Naltrexone for sexual sadism disorder in an adolescent. 62
36282610 2022
3
Sadistic Sexual Crimes Against Children: Comparing the Manifestation of Sexual Sadism and Crime-Commission Process. 62
36377559 2022
4
Manifestations of sexual sadism in child sexual assault and the associated victim, offender, and offense characteristics: A latent class analysis. 62
35905588 2022
5
Sexual Sadism Disorder and Coercive Paraphilic Disorder: A Scoping Review. 62
35153163 2022
6
From Fantasy to Reality: Self-Reported Aggression-Related Sexual Fantasies Predict Sexually Sadistic Behavior beyond Indirect and Direct Measures of Sexual Preference. 62
35040707 2022
7
Hormonal response to perceived emotional distress in incarcerated men with sexual sadism. 62
34483420 2022
8
Sexual Sadism: Its Role in the Crime-Commission Process of Sexual Homicide of Children. 62
32370642 2022
9
Criminal mutilation in Sweden from 1991 to 2017. 62
33955549 2021
10
Neural Correlates of Moral Judgment in Criminal Offenders with Sadistic Traits. 62
33156438 2021
11
The Third Backdoor: How the DSM Casebooks Pathologized Homosexuality. 62
34282998 2021
12
Stigmatization of Paraphilias and Psychological Conditions Linked to Sexual Offending. 62
32352329 2021
13
ICD-11 Paraphilic Disorders: A South African Analysis of Its Utility in the Medico-Legal Context. 62
33640276 2021
14
Is Investigative Awareness a Distinctive Feature of Sexual Sadism? 62
29294688 2020
15
Sexual Sadism Among Sex Offenders in Switzerland. 62
30226446 2020
16
Coercive Sexual Sadism: a Systematic Qualitative Review. 62
31811477 2019
17
Current Legal Situation for Patients with Paraphilic disorders and Implications of the ICD-11 for Paraphilic Disorders for Germany. 62
31447381 2019
18
Childhood sexual abuse is significantly associated with subsequent sexual offending: New evidence among federal correctional clients. 62
31252352 2019
19
Sexual Sadism and Psychopathy in Sexual Homicide Offenders: An Exploration of Their Associates in a Clinical Sample. 62
30897982 2019
20
An Updated Sexual Homicide Crime Scene Rating Scale for Sexual Sadism (SADSEX-SH). 62
30947588 2019
21
Personality Disorder Features and Paraphilic Interests Among Undergraduates: Differential Relations and Potential Antecedents. 62
29120276 2019
22
MTC Sadism Scale: Toward a Dimensional Assessment of Severe Sexual Sadism With Behavioral Markers. 62
29058955 2019
23
Sadism among sexual homicide offenders: Validation of the Sexual Sadism Scale. 62
30321018 2019
24
Convergent Validity of Three Measures of Sexual Sadism: Value of a Dimensional Measure. 62
27229922 2018
25
Sadistic Offender or Sexual Sadism? Taxometric Evidence for a Dimensional Structure of Sexual Sadism. 62
29204815 2018
26
Proposals for Paraphilic Disorders in the International Classification of Diseases and Related Health Problems, Eleventh Revision (ICD-11). 62
28210933 2017
27
Sexual homicide: Brief review of the literature and case report involving rape, genital mutilation and human arson. 62
28024267 2017
28
Paraphilic Sexual Interests and Sexually Coercive Behavior: A Population-Based Twin Study. 62
26754158 2016
29
Sadism and Violent Reoffending in Sexual Offenders. 62
25567533 2016
30
Assessment of the paraphilias. 62
24877702 2014
31
Sexual sadism in sexual offenders and sexually motivated homicide. 62
24877708 2014
32
When benefitting a patient increases the risk for harm for third persons - the case of treating pedophilic Parkinsonian patients with deep brain stimulation. 62
24289863 2014
33
Sadism in sexual offenders: evidence for dimensionality. 62
24219703 2014
34
Relating sexual sadism and psychopathy to one another, non-sexual violence, and sexual crime behaviors. 62
24019144 2014
35
Sexual sadism: current diagnostic vagueness and the benefit of behavioral definitions. 62
23188927 2013
36
The importance of behavioral factors in the diagnosis of severe sexual sadism. 62
24196138 2013
37
Sexual sadism in the context of rape and sexual homicide: an examination of crime scene indicators. 62
22436735 2013
38
Pathologizing sexual deviance: a history. 62
23480073 2013
39
The Severe Sexual Sadism Scale: cross-validation and scale properties. 62
22142424 2012
40
The sexual responses of sexual sadists. 62
22708887 2012
41
Empathy in sexually sadistic offenders: an experimental comparison with non-sadistic sexual offenders. 62
22417758 2012
42
Increased frontotemporal activation during pain observation in sexual sadism: preliminary findings. 62
22393220 2012
43
Axis I psychiatric disorders, paraphilic sexual offending and implications for pharmacological treatment. 62
23585462 2012
44
Sexual sadism: avoiding its misuse in sexually violent predator evaluations. 62
22960924 2012
45
Sociodemographic and diagnostic characteristics of homicidal and nonhomicidal sexual offenders. 62
21981447 2011
46
Psychopathy and sexual sadism. 62
20393872 2011
47
Behavioral discriminators of sexual sadism and paraphilia nonconsent in a sample of civilly committed sexual offenders. 62
20622251 2011
48
Serial murder of four victims, of both genders and different ethnicities, by an ordained baptist minister. 62
22937398 2011
49
Depathologizing consensual sexual sadism, sexual masochism, transvestic fetishism, and fetishism. 62
20632078 2010
50
Comparing indicators of sexual sadism as predictors of recidivism among adult male sexual offenders. 62
20658813 2010

Variations for Sexual Sadism

Expression for Sexual Sadism

Search GEO for disease gene expression data for Sexual Sadism.

Pathways for Sexual Sadism

GO Terms for Sexual Sadism

Biological processes related to Sexual Sadism according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 sleep GO:0030431 9.85 OXTR OXT
2 drinking behavior GO:0042756 9.83 OXT DRD2
3 dopamine catabolic process GO:0042420 9.81 MAOA COMT
4 positive regulation of uterine smooth muscle contraction GO:0070474 9.8 OXTR OXT
5 response to amphetamine GO:0001975 9.8 OXTR OXT DRD2
6 neurotransmitter catabolic process GO:0042135 9.78 MAOA COMT
7 sperm ejaculation GO:0042713 9.76 OXTR OXT
8 female pregnancy GO:0007565 9.76 PRL OXTR OXT CRH
9 negative regulation of gastric acid secretion GO:0060455 9.73 OXTR OXT
10 response to cocaine GO:0042220 9.73 OXTR OXT DRD2
11 positive regulation of penile erection GO:0060406 9.71 OXTR OXT
12 positive regulation of norepinephrine secretion GO:0010701 9.67 OXT OXTR
13 response to unfolded protein GO:0006986 9.56 HSPB3 HSPB2 HSPB1 HSPA4
14 catecholamine metabolic process GO:0006584 9.54 MAOA COMT
15 regulation of digestive system process GO:0044058 8.62 OXTR OXT

Molecular functions related to Sexual Sadism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 PRL POMC OXT CRH

Sources for Sexual Sadism

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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