MCID: SXL001
MIFTS: 31

Sexual Sadism

Categories: Mental diseases

Aliases & Classifications for Sexual Sadism

MalaCards integrated aliases for Sexual Sadism:

Name: Sexual Sadism 12 15 70
Sadism 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10817
ICD9CM 34 302.84
MeSH 44 D012448
NCIt 50 C94358
SNOMED-CT 67 59394009
ICD10 32 F65.52
UMLS 70 C0036039 C0036913

Summaries for Sexual Sadism

MalaCards based summary : Sexual Sadism, also known as sadism, is related to paraphilia disorder and pedophilia. An important gene associated with Sexual Sadism is TTF2 (Transcription Termination Factor 2), and among its related pathways/superpathways are Neurotransmitter Clearance In The Synaptic Cleft and Methylphenidate Pathway, Pharmacodynamics. Affiliated tissues include brain, kidney and appendix, and related phenotypes are endocrine/exocrine gland and integument

Wikipedia : 73 Sexual sadism disorder is the condition of experiencing sexual arousal in response to the extreme pain,... more...

Related Diseases for Sexual Sadism

Diseases related to Sexual Sadism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 paraphilia disorder 30.2 OXT MAOA
2 pedophilia 29.6 PRL OXT MAOA
3 personality disorder 29.3 PRL MAOA CRH COMT BDNF
4 antisocial personality disorder 29.3 TTF2 PRL OXT MAOA COMT
5 borderline personality disorder 28.8 PRL MAOA CRH COMT BDNF
6 substance abuse 28.8 PRL MAOA CRH COMT BDNF
7 sexual masochism 10.4
8 tic disorder 10.2 MAOA COMT
9 fetishism 10.2
10 kleptomania 10.2 MAOA COMT
11 pure autonomic failure 10.2 PDE5A MAOA
12 impulse control disorder 10.1 MAOA COMT
13 hypoactive sexual desire disorder 10.1 PDE5A OXT
14 transient global amnesia 10.1 PDE5A BDNF
15 body dysmorphic disorder 10.1 OXT MAOA
16 pathological gambling 10.1 MAOA COMT
17 serotonin syndrome 10.1 OXT MAOA
18 traumatic brain injury 10.1 COMT BDNF
19 brain injury 10.1 COMT BDNF
20 mild cognitive impairment 10.1 COMT BDNF
21 brunner syndrome 10.0 TTF2 MAOA COMT
22 avoidant personality disorder 10.0
23 voyeurism 10.0
24 cannabis abuse 10.0 COMT BDNF
25 dissociative disorder 10.0 OXT BDNF
26 hypochondriasis 10.0 OXT BDNF
27 childhood disintegrative disease 10.0 OXT BDNF
28 asphyxia neonatorum 10.0 OXT BDNF
29 narcissistic personality disorder 10.0 TTF2 OXT MAOA
30 meconium aspiration syndrome 10.0 PDE5A OXT
31 alexithymia 10.0 OXT COMT
32 inappropriate adh syndrome 9.9 OXT CRH
33 flying phobia 9.9 OXT MAOA COMT
34 intermittent explosive disorder 9.9 OXT MAOA COMT
35 bestiality 9.9 OXT MAOA COMT
36 separation anxiety disorder 9.9 OXT MAOA COMT
37 oppositional defiant disorder 9.9 OXT MAOA COMT
38 heroin dependence 9.9 MAOA COMT BDNF
39 morphine dependence 9.9 OXT CRH
40 amnestic disorder 9.9 OXT BDNF
41 generalized anxiety disorder 9.9 MAOA COMT BDNF
42 wolfram syndrome 1 9.9 CRH COMT
43 trichotillomania 9.9 PRL MAOA
44 lactocele 9.9 PRL OXT
45 premature ejaculation 9.9 PDE5A OXT COMT
46 agoraphobia 9.9 MAOA CRH COMT
47 atypical depressive disorder 9.8 MAOA CRH BDNF
48 ectopic cushing syndrome 9.8 PRL CRH
49 narcolepsy 9.8 MAOA COMT BDNF
50 pituitary infarct 9.8 PRL CRH

Graphical network of the top 20 diseases related to Sexual Sadism:



Diseases related to Sexual Sadism

Symptoms & Phenotypes for Sexual Sadism

MGI Mouse Phenotypes related to Sexual Sadism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 BDNF COMT CRH MFGE8 OXT PRL
2 integument MP:0010771 9.43 BDNF CRH MFGE8 OXT PDGFB PRL
3 nervous system MP:0003631 9.23 BDNF COMT CRH MAOA OXT PDE5A

Drugs & Therapeutics for Sexual Sadism

Search Clinical Trials , NIH Clinical Center for Sexual Sadism

Cochrane evidence based reviews: sadism

Genetic Tests for Sexual Sadism

Anatomical Context for Sexual Sadism

MalaCards organs/tissues related to Sexual Sadism:

40
Brain, Kidney, Appendix

Publications for Sexual Sadism

Articles related to Sexual Sadism:

(show top 50) (show all 261)
# Title Authors PMID Year
1
Sadism and psychopathy in violent and sexually violent offenders. 61 54
10212024 1999
2
Is the COVID-19 pandemic even darker for some? Examining dark personality and affective, cognitive, and behavioral responses to the COVID-19 pandemic. 61
33191963 2021
3
Themes of the dark core of personality. 61
33779194 2021
4
An Examination of Empathy and Interpersonal Dominance in BDSM Practitioners. 61
33547018 2021
5
Beyond Pain: A Study on the Variance of Pain Thresholds Within BDSM Interactions in Dominants and Submissives. 61
33642237 2021
6
ICD-11 Paraphilic Disorders: A South African Analysis of Its Utility in the Medico-Legal Context. 61
33640276 2021
7
Same Personality, New Ways to Abuse: How Dark Tetrad Personalities Are Connected With Cyber Intimate Partner Violence. 61
33546557 2021
8
Study addiction and 'dark' personality traits: a cross-sectional survey study among emerging adults. 61
33499773 2021
9
Examining the Short Dark Tetrad (SD4) Across Models, Correlates, and Gender. 61
33445956 2021
10
Foreign Object Insertion in Sexual Homicide: A New Perspective. 61
33261532 2020
11
Enthusiastic Acts of Evil: The Assessment of Sadistic Personality in Polish and Italian Populations. 61
31609650 2020
12
Effect of revenge on sadism and schadenfreude in clinical and non clinical adults: moderating role of misanthropic beliefs. 61
33341836 2020
13
Neural Correlates of Moral Judgment in Criminal Offenders with Sadistic Traits. 61
33156438 2020
14
On the relation of boredom and sadistic aggression. 61
33030934 2020
15
Concordance of Paraphilic Interests and Behaviors. 61
33112690 2020
16
Dark tetrad personality traits and counterproductive work behavior among doctors in Pakistan. 61
32744736 2020
17
The Role of Consent in the Context of BDSM. 61
31010393 2020
18
Common, nonsexual masochistic preferences are positively associated with antisocial personality traits. 61
31733145 2020
19
High Esteem and Hurting Others Online: Trait Sadism Moderates the Relationship Between Self-Esteem and Internet Trolling. 61
32364769 2020
20
Extending the nomological network of sexual objectification to psychopathic and allied personality traits. 61
31714098 2020
21
Psychopathy subfactors distinctively predispose to dispositional and state-level of sadistic pleasure. 61
30797521 2020
22
What Is So Appealing About Being Spanked, Flogged, Dominated, or Restrained? Answers from Practitioners of Sexual Masochism/Submission. 61
32486920 2020
23
Sexual Sadism: Its Role in the Crime-Commission Process of Sexual Homicide of Children. 61
32370642 2020
24
Physical Pain as Pleasure: A Theoretical Perspective. 61
31044619 2020
25
Between Pleasure and Pain: A Pilot Study on the Biological Mechanisms Associated With BDSM Interactions in Dominants and Submissives. 61
32044259 2020
26
Is Investigative Awareness a Distinctive Feature of Sexual Sadism? 61
29294688 2020
27
Stigmatization of Paraphilias and Psychological Conditions Linked to Sexual Offending. 61
32352329 2020
28
Sexual Sadism Among Sex Offenders in Switzerland. 61
30226446 2020
29
Offenders convicted of child sexual exploitation material offences: characteristics of offenders and an exploration of judicial censure. 61
33679203 2020
30
The Dark Tetrad and Male Clients of Female Sex Work. 61
33071917 2020
31
A Survey on BDSM-related Activities: BDSM Experience Correlates with Age of First Exposure, Interest Profile, and Role Identity. 61
30676097 2020
32
Childhood Emotional Abuse and Cyberbullying Perpetration: The Role of Dark Personality Traits. 61
31789089 2019
33
Coercive Sexual Sadism: a Systematic Qualitative Review. 61
31811477 2019
34
Rape of the lock: note on nineteenth-century hair fetishists. 61
31328573 2019
35
Sexual Homicide: a Criminological Perspective. 61
31734801 2019
36
Current Legal Situation for Patients with Paraphilic disorders and Implications of the ICD-11 for Paraphilic Disorders for Germany. 61
31447381 2019
37
Non-Natural Death Associated with Sexual Activity: Results of a 25-Year Medicolegal Postmortem Study. 61
31447384 2019
38
Childhood sexual abuse is significantly associated with subsequent sexual offending: New evidence among federal correctional clients. 61
31252352 2019
39
Sadism and Aggressive Behavior: Inflicting Pain to Feel Pleasure. 61
30571456 2019
40
Examining the Dark Tetrad and Its Links to Cyberbullying. 61
31403853 2019
41
Foreign Object Insertions in Sexual Homicide. 61
30526154 2019
42
Sexual Homicide Targeting Children: Exploring Offender, Victim, and Modus Operandi Factors. 61
30675817 2019
43
An Updated Sexual Homicide Crime Scene Rating Scale for Sexual Sadism (SADSEX-SH). 61
30947588 2019
44
Sexual Sadism and Psychopathy in Sexual Homicide Offenders: An Exploration of Their Associates in a Clinical Sample. 61
30897982 2019
45
Bondage-Discipline, Dominance-Submission and Sadomasochism (BDSM) From an Integrative Biopsychosocial Perspective: A Systematic Review. 61
30956128 2019
46
Buttock Lesions Resulting from Heavy Bondage/Discipline/Sadism/Masochism (BDSM) Play in an 82-Year-Old Male. 61
30671874 2019
47
BDSM, becoming and the flows of desire. 61
30040546 2019
48
Internet trolling and everyday sadism: Parallel effects on pain perception and moral judgment. 61
29663396 2019
49
Are Role and Gender Related to Sexual Function and Satisfaction in Men and Women Practicing BDSM? 61
30773495 2019
50
Are everyday sadists specifically attracted to violent video games and do they emotionally benefit from playing those games? 61
30585333 2019

Variations for Sexual Sadism

Expression for Sexual Sadism

Search GEO for disease gene expression data for Sexual Sadism.

Pathways for Sexual Sadism

GO Terms for Sexual Sadism

Cellular components related to Sexual Sadism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 PRL PDGFB OXT MFGE8 CRH BDNF
2 extracellular space GO:0005615 9.1 PRL PDGFB OXT MFGE8 CRH BDNF

Biological processes related to Sexual Sadism according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.91 PRL PDGFB PDE5A OXT CRH BDNF
2 response to cocaine GO:0042220 9.49 OXT CRH
3 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.48 PRL PDGFB
4 regulation of sensory perception of pain GO:0051930 9.46 OXT COMT
5 response to pain GO:0048265 9.4 CRH COMT
6 positive regulation of calcium ion import GO:0090280 9.37 PDGFB CRH
7 catecholamine metabolic process GO:0006584 9.32 MAOA COMT
8 neurotransmitter catabolic process GO:0042135 9.26 MAOA COMT
9 dopamine catabolic process GO:0042420 9.16 MAOA COMT
10 response to ether GO:0045472 8.96 OXT CRH
11 female pregnancy GO:0007565 8.92 PRL OXT CRH COMT

Molecular functions related to Sexual Sadism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 OXT CRH
2 hormone activity GO:0005179 8.8 PRL OXT CRH

Sources for Sexual Sadism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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