MCID: SHH001
MIFTS: 51

Sheehan Syndrome

Categories: Blood diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Sheehan Syndrome

MalaCards integrated aliases for Sheehan Syndrome:

Name: Sheehan Syndrome 12 76 53 59 55 15 73
Postpartum Hypopituitarism 12 53
Postpartum Panhypopituitary Syndrome 53
Postpartum Panhypopituitarism 53
Postpartum Pituitary Necrosis 53
Sheehan's Syndrome 12
Simmond's Disease 53

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Sheehan Syndrome

NIH Rare Diseases : 53 Sheehan syndrome, or postpartum hypopituitarism, is a rare complication of postpartum hemorrhage. Severe blood loss during or after childbirth can deprive the body of oxygen and seriously damage the pituitary gland. This causes the gland to permanently lose its ability to function properly. Symptoms vary, from failure to lactate, to nonspecific symptoms like fatigue, to adrenal crisis (a life-threatening shortage of the hormone cortisol). Treatment involves lifelong hormone replacement therapy.

MalaCards based summary : Sheehan Syndrome, also known as postpartum hypopituitarism, is related to pituitary hormone deficiency, combined, 2 and conn's syndrome. An important gene associated with Sheehan Syndrome is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Peptide hormone metabolism. Affiliated tissues include pituitary, thyroid and heart, and related phenotypes are obesity and diplopia

Wikipedia : 76 Sheehan''s syndrome, also known as postpartum pituitary gland necrosis, is hypopituitarism (decreased... more...

Related Diseases for Sheehan Syndrome

Diseases related to Sheehan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 pituitary hormone deficiency, combined, 2 31.3 IGF1 POMC PRL
2 conn's syndrome 29.6 CRH POMC PRL
3 diabetes insipidus 29.6 CRH INS POMC PRL
4 hypothyroidism 29.5 IGF1 POMC PRL
5 hyperprolactinemia 29.5 IGF1 POMC PRL
6 hypopituitarism 29.1 CRH IGF1 INS POMC PRL
7 diabetic autonomic neuropathy 10.1 EPO INS
8 plethora of newborn 10.1 EPO INS
9 granulosa cell tumor of the ovary 10.1 INS PRL
10 melancholia 10.1 CRH PRL
11 spinocerebellar degeneration 10.1 CRH PRL
12 chiasmal syndrome 10.1 POMC PRL
13 burns 10.1 CRH INS
14 adenohypophysitis 10.1 POMC PRL
15 sella turcica neoplasm 10.1 POMC PRL
16 sleep disorder 10.1 INS PRL
17 tuberculum sellae meningioma 10.1 POMC PRL
18 postpartum depression 10.1 CRH PRL
19 noma 10.1 INS POMC
20 tsh producing pituitary tumor 10.1 POMC PRL
21 abducens nerve disease 10.1 POMC PRL
22 functioning pituitary adenoma 10.1 POMC PRL
23 scleredema adultorum 10.1 INS POMC
24 pancreatic endocrine carcinoma 10.1 INS POMC
25 rh isoimmunization 10.1 EPO POMC
26 mucinoses 10.1 INS POMC
27 adrenal rest tumor 10.1 POMC PRL
28 diabetic neuropathy 10.0 EPO INS
29 pigmentation disease 10.0 INS POMC
30 gangliocytoma 10.0 CRH POMC
31 neurodermatitis 10.0 INS POMC
32 acth deficiency, isolated 10.0 CRH POMC
33 gynecomastia 10.0 POMC PRL
34 hypoadrenalism 10.0 CRH POMC
35 galactorrhea 10.0 IGF1 PRL
36 adrenal cortical hypofunction 10.0 CRH POMC
37 endogenous depression 10.0 CRH INS
38 pseudohypoparathyroidism, type ia 10.0 IGF1 PRL
39 withdrawal disorder 10.0 CRH POMC
40 mammographic density 10.0 IGF1 PRL
41 ectopic cushing syndrome 10.0 CRH POMC
42 persistent fetal circulation syndrome 10.0 CRH POMC
43 adrenal gland disease 10.0 CRH POMC
44 secondary adrenal insufficiency 10.0 IGF1 INS
45 pituitary adenoma 1, multiple types 10.0 IGF1 PRL
46 thyroiditis 10.0
47 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.0 IGF1 INS
48 hypoadrenocorticism, familial 10.0 CRH POMC
49 donohue syndrome 10.0 IGF1 INS
50 dilated cardiomyopathy 10.0

Graphical network of the top 20 diseases related to Sheehan Syndrome:



Diseases related to Sheehan Syndrome

Symptoms & Phenotypes for Sheehan Syndrome

Human phenotypes related to Sheehan Syndrome:

59 32 (show all 49)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 obesity 59 32 occasional (7.5%) Occasional (29-5%) HP:0001513
2 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
3 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
4 constipation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002019
5 sensorineural hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000407
6 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
7 hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0001943
8 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
9 dry skin 59 32 frequent (33%) Frequent (79-30%) HP:0000958
10 hashimoto thyroiditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000872
11 psychosis 59 32 very rare (1%) Very rare (<4-1%) HP:0000709
12 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
13 chronic fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012432
14 coma 59 32 very rare (1%) Very rare (<4-1%) HP:0001259
15 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
16 blurred vision 59 32 frequent (33%) Frequent (79-30%) HP:0000622
17 panhypopituitarism 59 32 hallmark (90%) Very frequent (99-80%) HP:0000871
18 dyspareunia 59 32 frequent (33%) Frequent (79-30%) HP:0030016
19 secondary growth hormone deficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0008240
20 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
21 decreased circulating cortisol level 59 32 hallmark (90%) Very frequent (99-80%) HP:0008163
22 decreased serum estradiol 59 32 frequent (33%) Frequent (79-30%) HP:0008214
23 orthostatic hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0001278
24 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
25 adrenocorticotropin deficient adrenal insufficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0011735
26 adrenocorticotropic hormone deficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0011748
27 antinuclear antibody positivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0003493
28 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
29 sparse pubic hair 59 32 frequent (33%) Frequent (79-30%) HP:0002225
30 sparse axillary hair 59 32 frequent (33%) Frequent (79-30%) HP:0002215
31 amenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000141
32 prolactin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008202
33 breast hypoplasia 59 32 frequent (33%) Frequent (79-30%) HP:0003187
34 poor appetite 59 32 occasional (7.5%) Occasional (29-5%) HP:0004396
35 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
36 central diabetes insipidus 59 32 very rare (1%) Very rare (<4-1%) HP:0000863
37 progressive visual field defects 59 32 frequent (33%) Frequent (79-30%) HP:0007987
38 palpitations 59 32 occasional (7.5%) Occasional (29-5%) HP:0001962
39 oligomenorrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0000876
40 bradycardia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001662
41 hyposthenuria 59 32 frequent (33%) Frequent (79-30%) HP:0003158
42 gonadotropin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008213
43 abnormal size of pituitary gland 59 32 frequent (33%) Frequent (79-30%) HP:0012504
44 chills 59 32 occasional (7.5%) Occasional (29-5%) HP:0025143
45 chronic lymphocytic meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0007041
46 thunderclap headache 59 32 occasional (7.5%) Occasional (29-5%) HP:0030907
47 normochromic anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001895
48 headache 59 Frequent (79-30%)
49 central adrenal insufficiency 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Sheehan Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 CRH EPO IGF1 INS LNPEP POMC
2 adipose tissue MP:0005375 9.77 CRH IGF1 INS LNPEP POMC
3 endocrine/exocrine gland MP:0005379 9.72 CRH IGF1 INS POMC PRL
4 immune system MP:0005387 9.63 CRH EPO IGF1 INS POMC PRL
5 integument MP:0010771 9.43 CRH EPO IGF1 INS POMC PRL
6 liver/biliary system MP:0005370 9.02 CRH EPO INS POMC PRL

Drugs & Therapeutics for Sheehan Syndrome

Search Clinical Trials , NIH Clinical Center for Sheehan Syndrome

Genetic Tests for Sheehan Syndrome

Anatomical Context for Sheehan Syndrome

MalaCards organs/tissues related to Sheehan Syndrome:

41
Pituitary, Thyroid, Heart, Skin, Brain, Pancreas, Cortex

Publications for Sheehan Syndrome

Articles related to Sheehan Syndrome:

(show top 50) (show all 57)
# Title Authors Year
1
Dental status, salivary flow, and sociodemographic aspects in Sheehan Syndrome patients. ( 29924763 )
2018
2
Acute Sheehan Syndrome Manifesting as Unremitting Headache. ( 29977451 )
2018
3
Sheehan syndrome mimicking dementia with Lewy bodies. ( 30426290 )
2018
4
Serum Lipid and Leptin Concentrations in Patients with Sheehan Syndrome. ( 30148090 )
2018
5
Sheehan Syndrome ( 29083621 )
2017
6
Psychiatric and Neurocognitive Manifestations of Sheehan Syndrome: A Case Report. ( 28234440 )
2017
7
Refractory hypotension induced by Sheehan syndrome with pituitary crisis: A case report. ( 28565814 )
2017
8
CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY. ( 27359291 )
2016
9
Sheehan syndrome. ( 28004658 )
2016
10
Chronic Sheehan syndrome presenting as pseudo-hypertrophic myopathy (Hoffman syndrome): A very rare combination. ( 27147175 )
2016
11
Sheehan syndrome. ( 28004764 )
2016
12
Sheehan syndrome presenting as pancytopenia Divendu Bhushan. ( 27727691 )
2016
13
Sheehan syndrome: acute presentation with severe headache. ( 25223643 )
2014
14
Evaluation of obstetrical factors related to Sheehan syndrome. ( 23945005 )
2014
15
Long-standing undiagnosed sheehan syndrome presenting as polymorphic and monomorphic ventricular tachycardia: a case series of 2 patients. ( 25100393 )
2014
16
Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome. ( 24842349 )
2014
17
Sheehan syndrome associated with raised intracranial pressure. ( 22790666 )
2013
18
Teaching neuroimages: sequential MRI of the pituitary in Sheehan syndrome. ( 22201118 )
2012
19
Sheehan syndrome in Costa Rica: clinical experience with 60 cases. ( 21041170 )
2011
20
Sheehan syndrome presenting as central diabetes insipidus: a rare presentation of an uncommon disorder. ( 21041172 )
2011
21
RE: Sheehan syndrome with reversible dilated cardiomyopathy. ( 21060164 )
2010
22
Sheehan syndrome with reversible dilated cardiomyopathy. ( 20622352 )
2010
23
The case: a female with hyponatremia. Diagnosis: Postpartum panhypopituitarism (Sheehan syndrome). ( 19904259 )
2009
24
Acute renal failure in a patient with Sheehan syndrome and rhabdomyolysis. ( 19367010 )
2008
25
Serum nitric oxide levels and flow-mediated dilatation in patients with Sheehan syndrome and the effect of combination therapy consisting of L-thyroxine, prednisolone, and conjugated estrogen/medroxyprogesterone acetate. ( 17582407 )
2008
26
Cardiac tamponade as a presenting manifestation of Sheehan syndrome. ( 19267038 )
2008
27
Sequential pituitary MR imaging in Sheehan syndrome: report of 2 cases. ( 18296547 )
2008
28
Sheehan syndrome presented with acute renal failure associated with rhabdomyolysis and hyponatraemia. ( 16263736 )
2006
29
Sheehan syndrome: clinical and laboratory evaluation of 20 cases. ( 15990732 )
2005
30
[Irreversible coma following hypoglycemia in Sheehan syndrome with adrenocortical insufficiency]. ( 12966633 )
2003
31
Sheehan syndrome. ( 12583962 )
2003
32
Sheehan syndrome: a splinter of the mind. ( 12686307 )
2003
33
Sheehan syndrome: a rare complication of postpartum hemorrhage. ( 11572546 )
2001
34
Sheehan syndrome presenting as early post-partum hyponatraemia. ( 10534518 )
1999
35
A case of Cushing's disease revealed six years after postpartum hypopituitarism. ( 10443666 )
1999
36
A case report of Sheehan syndrome presenting with diabetes insipidus. ( 9653868 )
1998
37
Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia. ( 8797063 )
1996
38
Acute hypoglycaemic coma--a rare, potentially lethal form of early onset Sheehan syndrome. ( 8546654 )
1995
39
Case report: postpartum hypopituitarism in a patient with sickle cell trait. ( 8010335 )
1994
40
A case of postpartum hypopituitarism associated with empty sella: possible relation to postpartum autoimmune hypophysitis. ( 7920896 )
1993
41
[Importance of prolactin level indication in detection of Sheehan syndrome]. ( 1304515 )
1992
42
Plasma vasopressin responses in postpartum hypopituitarism: impaired response to osmotic stimuli. ( 1492537 )
1992
43
Simultaneous occurrence of postpartum hypopituitarism (Sheehan's syndrome) and transient resolving thyrotoxicosis due to postpartum painless thyroiditis. ( 1604398 )
1992
44
Postpartum hypopituitarism with preservation of the pituitary-ovarian axis. ( 2108583 )
1990
45
Neurohypophyseal function in postpartum hypopituitarism: impaired plasma vasopressin response to osmotic stimuli. ( 2918058 )
1989
46
A case of postpartum hypopituitarism (Sheehan's syndrome) associated with severe hyponatremia and congestive heart failure. ( 3264036 )
1988
47
Screening test for Sheehan syndrome. ( 6436762 )
1984
48
Recognition of diabetes insipidus in postpartum hypopituitarism. ( 6804902 )
1982
49
Serum prolactin during pregnancy induced by pituitary gonadotrophins in a patient with post partum hypopituitarism (Sheehan syndrome). ( 6788010 )
1981
50
Postpartum hypopituitarism adn hyperprolactinemia. ( 7190359 )
1980

Variations for Sheehan Syndrome

Expression for Sheehan Syndrome

Search GEO for disease gene expression data for Sheehan Syndrome.

Pathways for Sheehan Syndrome

GO Terms for Sheehan Syndrome

Cellular components related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CRH EPO IGF1 INS POMC PRL
2 extracellular region GO:0005576 9.17 CRH EPO IGF1 INS LNPEP POMC
3 endosome lumen GO:0031904 9.16 INS PRL

Biological processes related to Sheehan Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 CRH IGF1 INS
2 cell proliferation GO:0008283 9.73 EPO IGF1 PRL
3 cell-cell signaling GO:0007267 9.67 INS LNPEP POMC
4 cellular protein metabolic process GO:0044267 9.61 IGF1 INS PRL
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.6 IGF1 INS
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.59 EPO IGF1
7 response to estrogen GO:0043627 9.58 CRH EPO
8 positive regulation of epithelial cell proliferation GO:0050679 9.57 IGF1 PRL
9 acute-phase response GO:0006953 9.55 EPO INS
10 activation of protein kinase B activity GO:0032148 9.54 IGF1 INS
11 positive regulation of glucose import GO:0046326 9.52 IGF1 INS
12 regulation of multicellular organism growth GO:0040014 9.51 IGF1 PRL
13 positive regulation of activated T cell proliferation GO:0042104 9.48 EPO IGF1
14 positive regulation of mitotic nuclear division GO:0045840 9.46 IGF1 INS
15 positive regulation of glycolytic process GO:0045821 9.4 IGF1 INS
16 positive regulation of Ras protein signal transduction GO:0046579 9.37 EPO IGF1
17 positive regulation of cell proliferation GO:0008284 9.35 CRH EPO IGF1 INS PRL
18 female pregnancy GO:0007565 9.33 CRH LNPEP PRL
19 positive regulation of glycogen biosynthetic process GO:0045725 9.32 IGF1 INS
20 parturition GO:0007567 9.26 CRH PRL
21 regulation of signaling receptor activity GO:0010469 9.02 EPO IGF1 INS POMC PRL

Molecular functions related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 IGF1 INS
2 hormone activity GO:0005179 9.1 CRH EPO IGF1 INS POMC PRL
3 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS

Sources for Sheehan Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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