MCID: SHH001
MIFTS: 50

Sheehan Syndrome

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Sheehan Syndrome

MalaCards integrated aliases for Sheehan Syndrome:

Name: Sheehan Syndrome 12 76 53 59 55 15 73
Postpartum Hypopituitarism 12 53
Postpartum Panhypopituitary Syndrome 53
Postpartum Panhypopituitarism 53
Postpartum Pituitary Necrosis 53
Sheehan's Syndrome 12
Simmond's Disease 53

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Sheehan Syndrome

NIH Rare Diseases : 53 Sheehan syndrome, or postpartum hypopituitarism, is a rare complication of postpartum hemorrhage. Severe blood loss during or after childbirth can deprive the body of oxygen and seriously damage the pituitary gland. This causes the gland to permanently lose its ability to function properly. Symptoms vary, from failure to lactate, to nonspecific symptoms like fatigue, to adrenal crisis (a life-threatening shortage of the hormone cortisol). Treatment involves lifelong hormone replacement therapy.

MalaCards based summary : Sheehan Syndrome, also known as postpartum hypopituitarism, is related to pituitary hormone deficiency, combined, 2 and diabetes insipidus. An important gene associated with Sheehan Syndrome is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Peptide hormone metabolism. Affiliated tissues include pituitary, skin and thyroid, and related phenotypes are dyspareunia and decreased female libido

Wikipedia : 76 Sheehan\'s syndrome, also known as postpartum pituitary gland necrosis, is hypopituitarism (decreased... more...

Related Diseases for Sheehan Syndrome

Diseases related to Sheehan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 pituitary hormone deficiency, combined, 2 30.5 IGF1 POMC PRL
2 diabetes insipidus 28.6 CRH INS POMC PRL
3 hypopituitarism 27.2 CRH IGF1 INS POMC PRL
4 diabetic autonomic neuropathy 10.4 EPO INS
5 granulosa cell tumor of the ovary 10.4 INS PRL
6 melancholia 10.4 CRH PRL
7 burns 10.3 CRH INS
8 adenohypophysitis 10.3 POMC PRL
9 postpartum depression 10.3 CRH PRL
10 chiasmal syndrome 10.3 POMC PRL
11 sella turcica neoplasm 10.3 POMC PRL
12 tuberculum sellae meningioma 10.3 POMC PRL
13 functioning pituitary adenoma 10.2 POMC PRL
14 diabetes insipidus, neurohypophyseal 10.2 POMC PRL
15 scleredema adultorum 10.2 INS POMC
16 rh isoimmunization 10.2 EPO POMC
17 reproductive system disease 10.1 INS PRL
18 noma 10.1 INS POMC
19 gynecomastia 10.1 POMC PRL
20 acth deficiency, isolated 10.1 CRH POMC
21 hypoadrenalism 10.1 CRH POMC
22 galactorrhea 10.1 IGF1 PRL
23 adrenal cortical hypofunction 10.1 CRH POMC
24 pseudohypoparathyroidism, type ia 10.1 IGF1 PRL
25 pituitary adenoma 1, multiple types 10.0 IGF1 PRL
26 withdrawal disorder 10.0 CRH POMC
27 mammographic density 10.0 IGF1 PRL
28 ectopic cushing syndrome 10.0 CRH POMC
29 hypoadrenocorticism, familial 10.0 CRH POMC
30 secondary adrenal insufficiency 10.0 IGF1 INS
31 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.0 IGF1 INS
32 mental depression 9.9 CRH POMC
33 adrenal adenoma 9.9 CRH POMC
34 donohue syndrome 9.9 IGF1 INS
35 diabetic neuropathy 9.9 EPO INS
36 mccune-albright syndrome 9.9 IGF1 PRL
37 fibrous dysplasia 9.9 IGF1 PRL
38 fetal macrosomia 9.9 IGF1 INS
39 brain injury 9.9 EPO IGF1
40 adrenal carcinoma 9.9 CRH POMC
41 dilated cardiomyopathy 9.9
42 headache 9.9
43 rubeosis iridis 9.8 IGF1 INS
44 pituitary apoplexy 9.8 INS POMC PRL
45 eating disorder 9.8 CRH POMC
46 sex differentiation disease 9.8 INS POMC PRL
47 chromophobe adenoma 9.8 INS POMC PRL
48 uremia 9.8 EPO INS
49 drug dependence 9.8 CRH POMC
50 female reproductive system disease 9.8 INS POMC PRL

Graphical network of the top 20 diseases related to Sheehan Syndrome:



Diseases related to Sheehan Syndrome

Symptoms & Phenotypes for Sheehan Syndrome

Human phenotypes related to Sheehan Syndrome:

59 32 (show all 49)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dyspareunia 59 32 frequent (33%) Frequent (79-30%) HP:0030016
2 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
3 sensorineural hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000407
4 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
5 hashimoto thyroiditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000872
6 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
7 obesity 59 32 occasional (7.5%) Occasional (29-5%) HP:0001513
8 bradycardia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001662
9 palpitations 59 32 occasional (7.5%) Occasional (29-5%) HP:0001962
10 constipation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002019
11 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
12 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
13 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
14 antinuclear antibody positivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0003493
15 poor appetite 59 32 occasional (7.5%) Occasional (29-5%) HP:0004396
16 chronic lymphocytic meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0007041
17 chills 59 32 occasional (7.5%) Occasional (29-5%) HP:0025143
18 thunderclap headache 59 32 occasional (7.5%) Occasional (29-5%) HP:0030907
19 psychosis 59 32 very rare (1%) Very rare (<4-1%) HP:0000709
20 central diabetes insipidus 59 32 very rare (1%) Very rare (<4-1%) HP:0000863
21 coma 59 32 very rare (1%) Very rare (<4-1%) HP:0001259
22 panhypopituitarism 59 32 hallmark (90%) Very frequent (99-80%) HP:0000871
23 oligomenorrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0000876
24 decreased circulating cortisol level 59 32 hallmark (90%) Very frequent (99-80%) HP:0008163
25 secondary growth hormone deficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0008240
26 adrenocorticotropin deficient adrenal insufficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0011735
27 adrenocorticotropic hormone deficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0011748
28 chronic fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012432
29 amenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000141
30 blurred vision 59 32 frequent (33%) Frequent (79-30%) HP:0000622
31 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
32 dry skin 59 32 frequent (33%) Frequent (79-30%) HP:0000958
33 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
34 orthostatic hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0001278
35 normochromic anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001895
36 hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0001943
37 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
38 sparse axillary hair 59 32 frequent (33%) Frequent (79-30%) HP:0002215
39 sparse pubic hair 59 32 frequent (33%) Frequent (79-30%) HP:0002225
40 hyposthenuria 59 32 frequent (33%) Frequent (79-30%) HP:0003158
41 breast hypoplasia 59 32 frequent (33%) Frequent (79-30%) HP:0003187
42 progressive visual field defects 59 32 frequent (33%) Frequent (79-30%) HP:0007987
43 prolactin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008202
44 gonadotropin deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008213
45 decreased serum estradiol 59 32 frequent (33%) Frequent (79-30%) HP:0008214
46 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
47 abnormal size of pituitary gland 59 32 frequent (33%) Frequent (79-30%) HP:0012504
48 headache 59 Frequent (79-30%)
49 central adrenal insufficiency 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Sheehan Syndrome:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.95 INS CRH EPO NEU1 IGF1 POMC
2 homeostasis/metabolism MP:0005376 9.95 PRL INS CRH EPO NEU1 IGF1
3 hematopoietic system MP:0005397 9.91 INS CRH EPO NEU1 IGF1 POMC
4 immune system MP:0005387 9.91 PRL NEU1 EPO IGF1 POMC INS
5 integument MP:0010771 9.87 PRL NEU1 EPO IGF1 POMC INS
6 endocrine/exocrine gland MP:0005379 9.85 PRL POMC INS CRH IGF1
7 adipose tissue MP:0005375 9.8 POMC INS CRH IGF1
8 liver/biliary system MP:0005370 9.73 PRL NEU1 EPO POMC INS CRH
9 nervous system MP:0003631 9.63 PRL INS CRH NEU1 IGF1 POMC
10 renal/urinary system MP:0005367 9.35 INS CRH NEU1 IGF1 POMC
11 skeleton MP:0005390 9.02 INS CRH EPO NEU1 IGF1

Drugs & Therapeutics for Sheehan Syndrome

Search Clinical Trials , NIH Clinical Center for Sheehan Syndrome

Genetic Tests for Sheehan Syndrome

Anatomical Context for Sheehan Syndrome

MalaCards organs/tissues related to Sheehan Syndrome:

41
Pituitary, Skin, Thyroid, Testes

Publications for Sheehan Syndrome

Articles related to Sheehan Syndrome:

(show all 40)
# Title Authors Year
1
Dental status, salivary flow, and sociodemographic aspects in Sheehan Syndrome patients. ( 29924763 )
2018
2
Acute Sheehan Syndrome Manifesting as Unremitting Headache. ( 29977451 )
2018
3
Sheehan Syndrome ( 29083621 )
2017
4
Psychiatric and Neurocognitive Manifestations of Sheehan Syndrome: A Case Report. ( 28234440 )
2017
5
Refractory hypotension induced by Sheehan syndrome with pituitary crisis: A case report. ( 28565814 )
2017
6
CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY. ( 27359291 )
2016
7
Sheehan syndrome. ( 28004658 )
2016
8
Chronic Sheehan syndrome presenting as pseudo-hypertrophic myopathy (Hoffman syndrome): A very rare combination. ( 27147175 )
2016
9
Sheehan syndrome. ( 28004764 )
2016
10
Sheehan syndrome presenting as pancytopenia Divendu Bhushan. ( 27727691 )
2016
11
Sheehan syndrome: acute presentation with severe headache. ( 25223643 )
2014
12
Evaluation of obstetrical factors related to Sheehan syndrome. ( 23945005 )
2014
13
Long-standing undiagnosed sheehan syndrome presenting as polymorphic and monomorphic ventricular tachycardia: a case series of 2 patients. ( 25100393 )
2014
14
Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome. ( 24842349 )
2014
15
Sheehan syndrome associated with raised intracranial pressure. ( 22790666 )
2013
16
Teaching neuroimages: sequential MRI of the pituitary in Sheehan syndrome. ( 22201118 )
2012
17
Sheehan syndrome in Costa Rica: clinical experience with 60 cases. ( 21041170 )
2011
18
Sheehan syndrome presenting as central diabetes insipidus: a rare presentation of an uncommon disorder. ( 21041172 )
2011
19
RE: Sheehan syndrome with reversible dilated cardiomyopathy. ( 21060164 )
2010
20
Sheehan syndrome with reversible dilated cardiomyopathy. ( 20622352 )
2010
21
The case: a female with hyponatremia. Diagnosis: Postpartum panhypopituitarism (Sheehan syndrome). ( 19904259 )
2009
22
Acute renal failure in a patient with Sheehan syndrome and rhabdomyolysis. ( 19367010 )
2008
23
Serum nitric oxide levels and flow-mediated dilatation in patients with Sheehan syndrome and the effect of combination therapy consisting of L-thyroxine, prednisolone, and conjugated estrogen/medroxyprogesterone acetate. ( 17582407 )
2008
24
Cardiac tamponade as a presenting manifestation of Sheehan syndrome. ( 19267038 )
2008
25
Sequential pituitary MR imaging in Sheehan syndrome: report of 2 cases. ( 18296547 )
2008
26
Sheehan syndrome presented with acute renal failure associated with rhabdomyolysis and hyponatraemia. ( 16263736 )
2006
27
Sheehan syndrome: clinical and laboratory evaluation of 20 cases. ( 15990732 )
2005
28
[Irreversible coma following hypoglycemia in Sheehan syndrome with adrenocortical insufficiency]. ( 12966633 )
2003
29
Sheehan syndrome. ( 12583962 )
2003
30
Sheehan syndrome: a splinter of the mind. ( 12686307 )
2003
31
Sheehan syndrome: a rare complication of postpartum hemorrhage. ( 11572546 )
2001
32
Sheehan syndrome presenting as early post-partum hyponatraemia. ( 10534518 )
1999
33
A case report of Sheehan syndrome presenting with diabetes insipidus. ( 9653868 )
1998
34
Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia. ( 8797063 )
1996
35
Acute hypoglycaemic coma--a rare, potentially lethal form of early onset Sheehan syndrome. ( 8546654 )
1995
36
[Importance of prolactin level indication in detection of Sheehan syndrome]. ( 1304515 )
1992
37
Screening test for Sheehan syndrome. ( 6436762 )
1984
38
Serum prolactin during pregnancy induced by pituitary gonadotrophins in a patient with post partum hypopituitarism (Sheehan syndrome). ( 6788010 )
1981
39
A PARANOID STATE IN A PATIENT SUFFERING FROM SHEEHAN SYNDROME. ( 14144444 )
1964
40
Simmonds-Sheehan syndrome. A brief discussion and case presentation. ( 13695019 )
1960

Variations for Sheehan Syndrome

Expression for Sheehan Syndrome

Search GEO for disease gene expression data for Sheehan Syndrome.

Pathways for Sheehan Syndrome

GO Terms for Sheehan Syndrome

Cellular components related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CRH EPO IGF1 INS POMC PRL
2 extracellular region GO:0005576 9.17 CRH EPO IGF1 INS NEU1 POMC
3 endosome lumen GO:0031904 9.16 INS PRL

Biological processes related to Sheehan Syndrome according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.75 CRH IGF1 INS
2 cell proliferation GO:0008283 9.74 EPO IGF1 PRL
3 cellular protein metabolic process GO:0044267 9.69 IGF1 INS PRL
4 response to insulin GO:0032868 9.61 IGF1 INS
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.6 IGF1 INS
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.59 EPO IGF1
7 response to estrogen GO:0043627 9.58 CRH EPO
8 acute-phase response GO:0006953 9.56 EPO INS
9 activation of protein kinase B activity GO:0032148 9.55 IGF1 INS
10 positive regulation of glucose import GO:0046326 9.54 IGF1 INS
11 regulation of multicellular organism growth GO:0040014 9.52 IGF1 PRL
12 glucose homeostasis GO:0042593 9.5 IGF1 INS POMC
13 positive regulation of mitotic nuclear division GO:0045840 9.49 IGF1 INS
14 positive regulation of activated T cell proliferation GO:0042104 9.48 EPO IGF1
15 positive regulation of Ras protein signal transduction GO:0046579 9.46 EPO IGF1
16 positive regulation of glycolytic process GO:0045821 9.43 IGF1 INS
17 response to nutrient levels GO:0031667 9.43 IGF1 INS PRL
18 positive regulation of insulin receptor signaling pathway GO:0046628 9.4 IGF1 INS
19 positive regulation of glycogen biosynthetic process GO:0045725 9.37 IGF1 INS
20 positive regulation of cell proliferation GO:0008284 9.35 CRH EPO IGF1 INS PRL
21 positive regulation of DNA replication GO:0045740 9.33 EPO IGF1 INS
22 regulation of signaling receptor activity GO:0010469 9.02 EPO IGF1 INS POMC PRL

Molecular functions related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.32 CRH POMC
2 insulin receptor binding GO:0005158 9.26 IGF1 INS
3 insulin-like growth factor receptor binding GO:0005159 9.16 IGF1 INS
4 hormone activity GO:0005179 9.1 CRH EPO IGF1 INS POMC PRL
5 receptor activator activity GO:0030546 8.96 IGF1 INS

Sources for Sheehan Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....