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MCID: SHH001
MIFTS: 47

Sheehan Syndrome

Categories: Blood diseases, Endocrine diseases, Rare diseases
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Aliases & Classifications for Sheehan Syndrome

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MalaCards integrated aliases for Sheehan Syndrome:

Name: Sheehan Syndrome 11 19 58 75 53 14 71
Postpartum Hypopituitarism 11 19
Sheehan's Syndrome 11 75
Postpartum Panhypopituitary Syndrome 19
Postpartum Panhypopituitarism 19
Postpartum Pituitary Necrosis 19
Simmond's Disease 19

Characteristics:


Age Of Onset:

Adult 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 31 32
Orphanet: 58  
Rare endocrine diseases


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Summaries for Sheehan Syndrome

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GARD: 19 Sheehan syndrome affects the function of the pituitary gland. The pituitary gland makes hormones and regulates other glands and many body processes, including reproduction. The cause of Sheehan syndrome is severe blood loss during or after childbirth (postpartum hemorrhage). This leads to lack of blood flow to the front part of the pituitary gland, causing it to gradually stop functioning. The symptoms of Sheehan syndrome occur as a result of the low hormone levels. These may include an inability to produce breast milk, irregular or absent periods, hot flashes, and a decreased sex drive. Other symptoms may include fatigue, headaches, low blood pressure, and hair loss. In some cases, the symptoms occur immediately and may be more severe and sometimes life threatening. Sheehan syndrome is diagnosed based on the symptoms, clinical history and exam, laboratory testing, and imaging studies.

MalaCards based summary: Sheehan Syndrome, also known as postpartum hypopituitarism, is related to premature ovarian failure 7 and diabetes insipidus, neurohypophyseal. An important gene associated with Sheehan Syndrome is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and G alpha (s) signalling events. Affiliated tissues include pituitary, breast and skin, and related phenotypes are chronic fatigue and panhypopituitarism

Orphanet: 58 Sheehan syndrome is a rare, acquired, pituitary hormone deficiency disorder resulting from pituitary necrosis following peri- or postpartum hemorrhage characterized by various symptoms depending on resulting hormone decrease (e.g. failure or difficulty with lactation, oligo- or amenorrhea, hot flashes, decreased libido, weakness, fatigue, anorexia, nausea, vomiting, hypoglycemia, hyponatremia, dizziness, decreased muscle mass, adrenal crisis). Secondary hypothyroidism and secondary adrenal insufficiency may also be presenting signs.

Wikipedia: 75 Sheehan's syndrome, also known as postpartum pituitary gland necrosis, is hypopituitarism (decreased... more...
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Related Diseases for Sheehan Syndrome

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Diseases related to Sheehan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 7 30.4 POMC GH1 CRH
2 diabetes insipidus, neurohypophyseal 30.1 POMC AVP
3 myxedema 30.1 POMC INS AVP
4 hypoglycemic coma 30.0 POMC INS
5 gestational diabetes 30.0 PRL INS IGF1
6 intracranial hypertension 30.0 PRL POMC AVP
7 neurotic disorder 29.9 POMC INS CRH
8 prediabetes syndrome 29.9 INS IGF1 GH1
9 central pontine myelinolysis 29.8 POMC INS AVP
10 insulin-like growth factor i 29.8 PRL INS IGF1 GH1
11 deficiency anemia 29.8 INS IGF1 GH1 AVP
12 pituitary tumors 29.8 PROP1 PRL IGF1 GH1
13 inappropriate adh syndrome 29.7 PRL POMC CRH AVP
14 graves disease 1 29.7 TRH POMC INS
15 turner syndrome 29.6 INS IGF1 GH1
16 goiter 29.6 TRH PRL INS IGF1
17 adrenal cortical carcinoma 29.6 POMC INS IGF1 CRH
18 mood disorder 29.6 TRH POMC CRH
19 hypokalemia 29.6 POMC INS CRH AVP
20 premature menopause 29.6 PRL POMC INS IGF1
21 psychotic disorder 29.6 PRL INS CRH
22 amenorrhea 29.6 TRH PRL POMC INS IGF1 CRH
23 melancholia 29.5 TRH PRL POMC CRH
24 hyperinsulinism 29.5 INS IGF1 GH1
25 lipid metabolism disorder 29.4 POMC INS IGF1
26 diabetes insipidus 29.4 PRL POMC INS GH1 CRH AVP
27 pituitary hormone deficiency, combined, 2 29.4 TRH PROP1 PRL POU1F1 POMC LHX4
28 central diabetes insipidus 29.3 TRH PRL POMC IGF1 GH1 AVP
29 hyperandrogenism 29.3 PRL POMC INS IGF1 GH1
30 glucose intolerance 29.3 PRL POMC INS IGF1 GH1
31 hypogonadotropic hypogonadism 29.2 PROP1 PRL POMC LHX4 INS IGF1
32 anorexia nervosa 29.2 PRL POMC INS IGF1 GH1 CRH
33 leptin deficiency or dysfunction 29.2 TRH POMC INS IGF1 CRH
34 pituitary-dependent cushing's disease 29.2 TRH PRL POMC GH1 CRH
35 hypoglycemia 29.2 TRH PRL POMC INS IGF1 GH1
36 hypogonadism 29.0 PROP1 PRL POMC INS IGF1 GH1
37 pituitary infarct 28.9 TRH PRL POMC INS IGF1 CRH
38 major depressive disorder 28.8 TRH PRL POMC INS CRH AVP
39 hyperthyroidism 28.8 TRH PRL POMC INS IGF1 GH1
40 hyperprolactinemia 28.8 TRH PRL POMC INS IGF1 GH1
41 hypothyroidism, congenital, nongoitrous, 4 28.7 PROP1 PRL POU1F1 POMC IGF1 GH1
42 diabetes mellitus 28.7 PRL POMC INS IGF1 GH1 CRH
43 pituitary apoplexy 28.7 TRH PRL POMC INS IGF1 GH1
44 empty sella syndrome 28.6 TRH PROP1 PRL POU1F1 POMC INS
45 acromegaly 28.5 TRH PRL POMC INS IGF1 GH1
46 conn's syndrome 28.5 TRH PRL POMC INS IGF1 GH1
47 pituitary adenoma 28.4 TRH PRL POU1F1 POMC IGF1 GH1
48 adenoma 28.4 TRH PRL POU1F1 POMC IGF1 GH1
49 hypopituitarism 28.3 TRH PROP1 PRL POU1F1 POMC LHX4
50 acth deficiency, isolated 28.3 TRH PROP1 PRL POU1F1 POMC LHX4

Graphical network of the top 20 diseases related to Sheehan Syndrome:



Diseases related to Sheehan Syndrome
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Symptoms & Phenotypes for Sheehan Syndrome

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Human phenotypes related to Sheehan Syndrome:

58 30 (show all 49)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chronic fatigue 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0012432
2 panhypopituitarism 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0000871
3 adrenocorticotropic hormone deficiency 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0011748
4 oligomenorrhea 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0000876
5 secondary growth hormone deficiency 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0008240
6 adrenocorticotropin deficient adrenal insufficiency 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0011735
7 decreased circulating cortisol level 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0008163
8 hypoglycemia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001943
9 dry skin 58 30 Frequent (33%) Frequent (79-30%)
 HP:0000958
10 pallor 58 30 Frequent (33%) Frequent (79-30%)
 HP:0000980
11 impotence 58 30 Frequent (33%) Frequent (79-30%)
 HP:0000802
12 dyspareunia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0030016
13 orthostatic hypotension 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001278
14 sparse axillary hair 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002215
15 sparse pubic hair 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002225
16 decreased serum estradiol 58 30 Frequent (33%) Frequent (79-30%)
 HP:0008214
17 breast hypoplasia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0003187
18 pituitary hypothyroidism 58 30 Frequent (33%) Frequent (79-30%)
 HP:0008245
19 amenorrhea 58 30 Frequent (33%) Frequent (79-30%)
 HP:0000141
20 nausea 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002018
21 reduced circulating prolactin concentration 58 30 Frequent (33%) Frequent (79-30%)
 HP:0008202
22 decreased female libido 58 30 Frequent (33%) Frequent (79-30%)
 HP:0030018
23 progressive visual field defects 58 30 Frequent (33%) Frequent (79-30%)
 HP:0007987
24 gonadotropin deficiency 58 30 Frequent (33%) Frequent (79-30%)
 HP:0008213
25 blurred vision 58 30 Frequent (33%) Frequent (79-30%)
 HP:0000622
26 abnormal size of pituitary gland 58 30 Frequent (33%) Frequent (79-30%)
 HP:0012504
27 hyposthenuria 58 30 Frequent (33%) Frequent (79-30%)
 HP:0003158
28 normochromic anemia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001895
29 diplopia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000651
30 constipation 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002019
31 muscle weakness 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001324
32 sensorineural hearing impairment 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000407
33 hashimoto thyroiditis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000872
34 obesity 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001513
35 vertigo 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002321
36 arthralgia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002829
37 hyponatremia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002902
38 poor appetite 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0004396
39 bradycardia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001662
40 chills 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0025143
41 palpitations 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001962
42 antinuclear antibody positivity 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0003493
43 chronic lymphocytic meningitis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0007041
44 thunderclap headache 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0030907
45 psychosis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000709
46 coma 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0001259
47 central diabetes insipidus 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000863
48 headache 58 Frequent (79-30%)
49 central adrenal insufficiency 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Sheehan Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.06 AVP CRH GH1 IGF1 INS LHX4
2 homeostasis/metabolism MP:0005376 9.9 AVP CRH GH1 IGF1 INS LHX4
3 renal/urinary system MP:0005367 9.8 AVP CRH GH1 IGF1 INS POMC
4 no phenotypic analysis MP:0003012 9.77 AVP CRH INS POMC TRH
5 endocrine/exocrine gland MP:0005379 9.65 CRH GH1 IGF1 INS LHX4 POMC
6 immune system MP:0005387 9.23 AVP CRH GH1 IGF1 INS POMC
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Drugs & Therapeutics for Sheehan Syndrome

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Search Clinical Trials, NIH Clinical Center for Sheehan Syndrome

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Genetic Tests for Sheehan Syndrome

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Anatomical Context for Sheehan Syndrome

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Organs/tissues related to Sheehan Syndrome:

MalaCards : Pituitary, Breast, Skin, Bone Marrow, Bone, Adrenal Cortex, Hypothalamus
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Publications for Sheehan Syndrome

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Articles related to Sheehan Syndrome:

(show top 50) (show all 847)
# Title Authors PMID Year
1
Characteristic features of 20 patients with Sheehan's syndrome. 53 62
16785150 2006
2
Sheehan's syndrome: baseline characteristics and effect of 2 years of growth hormone replacement therapy in 91 patients in KIMS - Pfizer International Metabolic Database. 53 62
15817914 2005
3
Magnetic resonance imaging in sheehan's syndrome: case report and literature review of imaging studies. 53 62
15251482 1997
4
Clinical and laboratory evaluation of 40 patients with Sheehan's syndrome. 53 62
7982772 1994
5
Plasma levels of corticotropin-releasing hormone in hypothalamic-pituitary-adrenal disorders and chronic renal failure. 53 62
8393256 1993
6
Hyperprolactinemia in a patient with Sheehan's syndrome. 53 62
1411718 1992
7
[Importance of prolactin level indication in detection of Sheehan syndrome]. 53 62
1304515 1992
8
Long-term hepatic and cardiac health in patients diagnosed with Sheehan's syndrome. 62
36243797 2022
9
Sheehan syndrome presenting as acute renal failure: A rare case report from Somalia. 62
36268361 2022
10
Erratum: Perinatal Management and Outcomes of Pregnancy Following Sheehan Syndrome: A Case Report and Literature Review: Erratum. 62
36342881 2022
11
Acute Sheehan's syndrome manifesting initially with diabetes insipidus postpartum: a case report and systematic literature review. 62
34779875 2022
12
A rare endocrine cause of ventricular tachycardia: a case series of two patients and a literature review. 62
36162825 2022
13
Muscle biopsy of Sheehan syndrome complicated with rhabdomyolysis: a case report. 62
36148541 2022
14
Clinical analysis of the serum muscle enzyme spectrum of patients with newly diagnosed Sheehan's syndrome. 62
36181079 2022
15
Central hypothyroidism with myxoedema: a less known but clinically challenging presentation. 62
36100285 2022
16
A Rare Case of Postpartum Panhypopituitarism Without Imaging Evidence of Sheehan's Syndrome. 62
36051726 2022
17
DHEA on Sexual Function in Sheehan Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial. 62
35481572 2022
18
A Challenging Diagnosis of Sheehan's Syndrome in Non-obstetric Critical Care and Emergency Settings: A Case Series of Five Patients with Varied Presentations. 62
36062035 2022
19
Quality of life in Sheehan Syndrome. 62
36248051 2022
20
Etiology and management of amenorrhea in adolescent and young adult women. 62
35525789 2022
21
[Internal medical emergencies in the pregnant patient : Peripartum sepsis, metabolic derailment, endocrinological emergencies and pulmonary edema]. 62
35312817 2022
22
A Rare Case of Sheehan Syndrome With Cardiac Tamponade. 62
35607582 2022
23
Prevalence of coronary calcium deposits in Sheehan's syndrome patients on long term replacement treatment. 62
34328604 2022
24
Acute Sheehan's Syndrome Presenting with Hyponatremia Followed by a Spontaneous Pregnancy. 62
36465526 2022
25
Transient Hepatitis Secondary to Zoledronic Acid in a Woman with Sheehan Syndrome. 62
35662756 2022
26
Case report: Pancytopenia as a rare presentation of Sheehan's syndrome. 62
35813355 2022
27
Reporte de caso: hipoglucemia grave como manifestación tardía de síndrome de Sheehan. 62
35350058 2022
28
Clinical Profile of Addison's Disease in a Tertiary Care Institute, Southern India - The Changing Landscape. 62
35662761 2022
29
Sexual Dysfunction in Sheehan Syndrome. 62
34311117 2021
30
Sheehan's syndrome as a mimic of premature ovarian insufficiency: need for advocacy. 62
33830850 2021
31
Management of a patient with Sheehan's syndrome and diabetes insipidus complicated by recurrent hyponatremia. 62
34515663 2021
32
[Internal medical emergencies in the pregnant patient : Peripartum sepsis, metabolic derailment, endocrinological emergencies and pulmonary edema]. 62
34143232 2021
33
Misleading normal TSH and persistently elevated creatine kinase: clues to the diagnosis of chronic Sheehan's syndrome. 62
34433531 2021
34
Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism. 62
34280894 2021
35
Recurrent hypoglycaemia and dilated cardiomyopathy: delayed presentation of Sheehan's syndrome. 62
34162619 2021
36
A Case of Sheehan Syndrome 7 Years Postpartum with Transaminitis and Hyperlipidemia. 62
33951030 2021
37
A 45-year-old female patient with Sheehan's syndrome presenting with imminent adrenal crisis: a case report. 62
33962642 2021
38
Pregnancy-associated diabetes insipidus in Japan-a review based on quoting from the literatures reported during the period from 1982 to 2019. 62
33775975 2021
39
Intraoperative central diabetes insipidus in a postpartum patient during decompression of base of brain lesion: Missing out the diagnosis of Sheehan's syndrome? 62
34188642 2021
40
Sheehan syndrome. 62
34125791 2021
41
Pituitary disease and pregnancy. 62
34167698 2021
42
Pituitary disease and pregnancy. 62
33358152 2021
43
Dilated Cardiomyopathy Reversibility in Sheehan's Syndrome: A Case Report. 62
33566997 2021
44
A Case of Burnt-Out Langerhans Cell Histiocytosis Presenting as Postpartum Hypopituitarism. 62
33851020 2021
45
Adrenal crisis precipitated by influenza A led to the diagnosis of Sheehan's syndrome 18 years after postpartum hemorrhage. 62
33363885 2020
46
Endocrine and Metabolic Manifestations of Snakebite Envenoming. 62
32602439 2020
47
Clinical, Endocrine, Metabolic Profile, and Bone Health in Sheehan's Syndrome. 62
33088757 2020
48
Hypopituitarism: A Rare but Often Neglected Condition. 62
32728328 2020
49
Unmasking of Hypoparathyroidism by Zoledronic Acid Infusion in a Patient with Sheehan Syndrome. 62
33083275 2020
50
[Headache in puerperium]. 62
32267645 2020
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Variations for Sheehan Syndrome

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Expression for Sheehan Syndrome

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Search GEO for disease gene expression data for Sheehan Syndrome.
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Pathways for Sheehan Syndrome

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Pathways related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 74
Show member pathways
 12.56 PRL INS IGF1 GH1
2
G alpha (s) signalling events 66
Show member pathways
 11.75 POMC CRH AVP
3
Adipogenesis 74
11.61 INS IGF1 GH1
4
Peptide hormone metabolism 66
Show member pathways
 11.49 POMC INS IGF1 GH1
5
Glucocorticoid receptor regulatory network 61
11.22 PRL POU1F1 POMC
6
Growth hormone receptor signaling 66
Show member pathways
 11.07 PRL GH1
7
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.91 TRH POMC
8
Serotonin and anxiety 74
Show member pathways
 10.87 POMC CRH
9
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.1 POMC CRH
10
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.1 PRL POMC INS
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GO Terms for Sheehan Syndrome

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Cellular components related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.1 PRL POMC INS IGF1 GH1 CRH
2 extracellular region GO:0005576 9.86 AVP CRH GH1 IGF1 INS POMC
3 secretory granule GO:0030141 9.63 TRH POMC AVP
4 endosome lumen GO:0031904 9.1 PRL INS GH1

Biological processes related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.76 TRH POMC INS AVP
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 INS IGF1 GH1
3 positive regulation of glycogen biosynthetic process GO:0045725 9.67 INS IGF1
4 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.62 IGF1 GH1
5 signal transduction GO:0007165 9.44 TRH PRL POMC INS IGF1 GH1
6 adenohypophysis development GO:0021984 9.13 PROP1 POU1F1

Molecular functions related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.47 TRH PRL POMC INS IGF1 GH1
2 insulin-like growth factor receptor binding GO:0005159 9.46 INS IGF1
3 prolactin receptor binding GO:0005148 9.26 PRL GH1
Sources

Sources for Sheehan Syndrome

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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