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MCID: SHH001
MIFTS: 44

Sheehan Syndrome

Categories: Blood diseases, Endocrine diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Sheehan Syndrome

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MalaCards integrated aliases for Sheehan Syndrome:

Name: Sheehan Syndrome 12 73 20 58 54 15 70
Postpartum Hypopituitarism 12 20
Postpartum Panhypopituitary Syndrome 20
Postpartum Panhypopituitarism 20
Postpartum Pituitary Necrosis 20
Sheehan's Syndrome 12
Simmond's Disease 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare endocrine diseases


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Summaries for Sheehan Syndrome

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GARD : 20 Sheehan syndrome affects the function of the pituitary gland. The pituitary gland makes hormones and regulates other glands and many body processes, including reproduction. The cause of Sheehan syndrome is severe blood loss during or after childbirth (postpartum hemorrhage). This leads to lack of blood flow to the front part of the pituitary gland, causing it to gradually stop functioning. The symptoms of Sheehan syndrome occur as a result of the low hormone levels. These may include an inability to produce breast milk, irregular or absent periods, hot flashes, and a decreased sex drive. Other symptoms may include fatigue, headaches, low blood pressure, and hair loss. Symptoms usually do not appear from months to years after the hemorrhage. In some cases, the symptoms occur immediately and may be more severe and sometimes life threatening. Sheehan syndrome is diagnosed based on the symptoms, clinical history and exam, laboratory testing, and imaging studies. Treatment includes hormone replacement therapy, and steroids to help manage early symptoms.

MalaCards based summary : Sheehan Syndrome, also known as postpartum hypopituitarism, is related to myxedema and secondary adrenal insufficiency. An important gene associated with Sheehan Syndrome is PRL (Prolactin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian rythm related genes. Affiliated tissues include pituitary and breast, and related phenotypes are chronic fatigue and panhypopituitarism

Wikipedia : 73 Sheehan's syndrome, also known as postpartum pituitary gland necrosis, is hypopituitarism (decreased... more...

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Related Diseases for Sheehan Syndrome

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Diseases related to Sheehan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 myxedema 30.2 POMC AVP
2 secondary adrenal insufficiency 30.2 INS IGF1 AVP
3 neurotic disorder 30.1 POMC INS
4 hypoglycemia 30.0 PRL POMC INS IGF1 CRH
5 graves disease 1 30.0 TRH POMC INS
6 hypothyroidism, congenital, nongoitrous, 4 30.0 PROP1 PRL POMC
7 pituitary tumors 29.9 PROP1 PRL POMC IGF1
8 inappropriate adh syndrome 29.9 POMC CRH AVP
9 hypokalemia 29.8 POMC INS CRH
10 diabetes insipidus 29.8 PRL POMC INS CRH AVP
11 mental depression 29.8 POMC INS CRH
12 hyperandrogenism 29.7 PRL POMC INS IGF1
13 goiter 29.7 TRH PRL INS IGF1
14 glucose intolerance 29.6 PRL POMC INS IGF1
15 hypogonadism 29.6 PROP1 PRL INS IGF1
16 amenorrhea 29.6 TRH PRL POMC INS IGF1 CRH
17 melancholia 29.6 TRH PRL POMC CRH
18 insulin-like growth factor i 29.6 PRL INS IGF1 GHRH
19 pituitary apoplexy 29.5 PRL POMC INS IGF1 AVP
20 empty sella syndrome 29.3 TRH PROP1 PRL POMC INS IGF1
21 hyperthyroidism 29.3 TRH PRL POMC INS IGF1
22 pituitary hormone deficiency, combined, 2 29.3 TRH PROP1 PRL POMC LHX4 IGF1
23 liver cirrhosis 29.1 INS IGF1 GHRH AVP
24 diabetes mellitus 29.0 PRL POMC INS IGF1 CRH AVP
25 anorexia nervosa 28.9 PRL POMC INS IGF1 GHRH CRH
26 pituitary adenoma 28.9 TRH PRL POMC IGF1 GHRH CRH
27 hyperprolactinemia 28.6 TRH PRL POMC INS IGF1 GHRH
28 acth deficiency, isolated 28.4 TRH PROP1 PRL POMC LHX4 HESX1
29 acromegaly 28.3 TRH PRL POMC INS IGF1 GHRH
30 pituitary infarct 28.2 TRH PRL POMC INS IGF1 GHRH
31 hypopituitarism 28.0 TRH PROP1 PRL POMC LHX4 INS
32 hypothyroidism 27.8 TRH PROP1 PRL POMC LHX4 INS
33 pituitary gland disease 27.4 TRH PROP1 PRL POMC LHX4 INS
34 pancytopenia 10.4
35 galactorrhea 10.3 PRL IGF1
36 abducens nerve disease 10.3 PRL POMC
37 tsh producing pituitary tumor 10.3 PRL POMC
38 functionless pituitary adenoma 10.3 POMC IGF1
39 sexual sadism 10.3 PRL CRH
40 partial third-nerve palsy 10.3 PRL IGF1
41 somatization disorder 10.3 POMC CRH
42 atypical depressive disorder 10.2 POMC CRH
43 tuberculous epididymitis 10.2 POMC AVP
44 ocular motor apraxia 10.2
45 van maldergem syndrome 1 10.2 PRL POMC
46 anterior cerebral artery infarction 10.2 PRL AVP
47 mixed cell adenoma 10.2 IGF1 CRH
48 adjustment disorder 10.2 POMC CRH
49 olfactory nerve neoplasm 10.2 POMC AVP
50 cranial nerve malignant neoplasm 10.2 POMC AVP

Graphical network of the top 20 diseases related to Sheehan Syndrome:



Diseases related to Sheehan Syndrome
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Symptoms & Phenotypes for Sheehan Syndrome

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Human phenotypes related to Sheehan Syndrome:

58 31 (show all 50)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chronic fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012432
2 panhypopituitarism 58 31 hallmark (90%) Very frequent (99-80%) HP:0000871
3 adrenocorticotropic hormone deficiency 58 31 hallmark (90%) Very frequent (99-80%) HP:0011748
4 secondary growth hormone deficiency 58 31 hallmark (90%) Very frequent (99-80%) HP:0008240
5 adrenocorticotropin deficient adrenal insufficiency 58 31 hallmark (90%) Very frequent (99-80%) HP:0011735
6 decreased circulating cortisol level 58 31 hallmark (90%) Very frequent (99-80%) HP:0008163
7 oligomenorrhea 58 31 hallmark (90%) Very frequent (99-80%) HP:0000876
8 hypoglycemia 58 31 frequent (33%) Frequent (79-30%) HP:0001943
9 dry skin 58 31 frequent (33%) Frequent (79-30%) HP:0000958
10 pallor 58 31 frequent (33%) Frequent (79-30%) HP:0000980
11 impotence 58 31 frequent (33%) Frequent (79-30%) HP:0000802
12 dyspareunia 58 31 frequent (33%) Frequent (79-30%) HP:0030016
13 orthostatic hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0001278
14 sparse axillary hair 58 31 frequent (33%) Frequent (79-30%) HP:0002215
15 sparse pubic hair 58 31 frequent (33%) Frequent (79-30%) HP:0002225
16 decreased serum estradiol 58 31 frequent (33%) Frequent (79-30%) HP:0008214
17 breast hypoplasia 58 31 frequent (33%) Frequent (79-30%) HP:0003187
18 pituitary hypothyroidism 58 31 frequent (33%) Frequent (79-30%) HP:0008245
19 amenorrhea 58 31 frequent (33%) Frequent (79-30%) HP:0000141
20 blurred vision 58 31 frequent (33%) Frequent (79-30%) HP:0000622
21 decreased female libido 58 31 frequent (33%) Frequent (79-30%) HP:0030018
22 progressive visual field defects 58 31 frequent (33%) Frequent (79-30%) HP:0007987
23 gonadotropin deficiency 58 31 frequent (33%) Frequent (79-30%) HP:0008213
24 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
25 abnormal size of pituitary gland 58 31 frequent (33%) Frequent (79-30%) HP:0012504
26 hyposthenuria 58 31 frequent (33%) Frequent (79-30%) HP:0003158
27 normochromic anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001895
28 reduced circulating prolactin concentration 31 frequent (33%) HP:0008202
29 diplopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000651
30 constipation 58 31 occasional (7.5%) Occasional (29-5%) HP:0002019
31 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
32 sensorineural hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000407
33 hashimoto thyroiditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000872
34 obesity 58 31 occasional (7.5%) Occasional (29-5%) HP:0001513
35 vertigo 58 31 occasional (7.5%) Occasional (29-5%) HP:0002321
36 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
37 hyponatremia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002902
38 poor appetite 58 31 occasional (7.5%) Occasional (29-5%) HP:0004396
39 antinuclear antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0003493
40 palpitations 58 31 occasional (7.5%) Occasional (29-5%) HP:0001962
41 bradycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001662
42 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
43 chronic lymphocytic meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0007041
44 thunderclap headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0030907
45 psychosis 58 31 very rare (1%) Very rare (<4-1%) HP:0000709
46 coma 58 31 very rare (1%) Very rare (<4-1%) HP:0001259
47 central diabetes insipidus 58 31 very rare (1%) Very rare (<4-1%) HP:0000863
48 headache 58 Frequent (79-30%)
49 prolactin deficiency 58 Frequent (79-30%)
50 central adrenal insufficiency 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Sheehan Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 CRH GHRH HESX1 IGF1 INS LHX4
2 homeostasis/metabolism MP:0005376 10.02 AVP CRH GHRH IGF1 INS LHX4
3 nervous system MP:0003631 10 AVP CRH GHRH HESX1 IGF1 INS
4 no phenotypic analysis MP:0003012 9.55 AVP CRH INS POMC TRH
5 renal/urinary system MP:0005367 9.43 AVP CRH IGF1 INS POMC TRH
6 respiratory system MP:0005388 9.1 AVP CRH HESX1 IGF1 LHX4 PROP1
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Drugs & Therapeutics for Sheehan Syndrome

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Search Clinical Trials , NIH Clinical Center for Sheehan Syndrome

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Genetic Tests for Sheehan Syndrome

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Anatomical Context for Sheehan Syndrome

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MalaCards organs/tissues related to Sheehan Syndrome:

40
Pituitary, Breast
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Publications for Sheehan Syndrome

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Articles related to Sheehan Syndrome:

(show top 50) (show all 202)
# Title Authors PMID Year
1
Sheehan syndrome. 20 61
28004764 2016
2
[Importance of prolactin level indication in detection of Sheehan syndrome]. 61 54
1304515 1992
3
Unmasking of Hypoparathyroidism by Zoledronic Acid Infusion in a Patient with Sheehan Syndrome. 61
33083275 2020
4
Sheehan Syndrome: An Unusual Presentation Without Inciting Factors. 61
33786491 2020
5
Characteristics of NAFLD Based on Hypopituitarism. 61
33102399 2020
6
Sheehan Syndrome Presenting with Psychotic Manifestations Mimicking Schizophrenia in a Young Female: A Case Report and Review of the Literature. 61
33343948 2020
7
Spontaneous Conception, Pericardial Effusion, and Pseudohypertrophic Myopathy Mimicking Muscular Dystrophy in Delayed Presentation of Sheehan Syndrome. 61
32129274 2020
8
Evaluation of bone texture imaging parameters on panoramic radiographs of patients with Sheehan's syndrome: a STROBE-compliant case-control study. 61
31372710 2019
9
Sheehan syndrome with Gitelman syndrome, Tackling Additive Morbidity. 61
31880589 2019
10
Perioperative management in a patient with panhypopituitarism - evidence based approach: a case report. 61
31660506 2019
11
Other Pituitary Conditions and Pregnancy. 61
31345525 2019
12
Treatment-triggered onset and diagnosis of Sheehan syndrome in a multiple myeloma patient. 61
32721123 2019
13
EVALUATION OF TREATMENT OF CENTRAL HYPOTHYROIDISM VERSUS PRIMARY HYPOTHYROIDISM IN RELATION TO LEVOTHYROXINE REPLACEMENT DOSE. 61
30865544 2019
14
Hypopituitarism other than sellar and parasellar tumors or traumatic brain injury assessed in a tertiary hospital. 61
31372159 2019
15
Sheehan syndrome mimicking dementia with Lewy bodies. 61
30426290 2019
16
Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome. 61
29463076 2018
17
Exploring circulatory shock and mortality in viper envenomation: a prospective observational study from India. 61
30107433 2018
18
MULTIFACETED EVALUATION OF 72 PATIENTS WITH PITUITARY FAILURE. 61
31149310 2018
19
Acute Sheehan Syndrome Manifesting as Unremitting Headache. 61
29977451 2018
20
Serum Lipid and Leptin Concentrations in Patients with Sheehan Syndrome. 61
30148090 2018
21
Dental status, salivary flow, and sociodemographic aspects in Sheehan Syndrome patients. 61
29924763 2018
22
Refractory Hypoglycemia and Seizures as the Initial Presenting Manifestation of Empty Sella Syndrome. 61
30116682 2018
23
Thyrotrophic status in patients with pituitary stalk interruption syndrome. 61
29480822 2018
24
A rare endocrine cause of electrical storm - a case report. 61
31020067 2017
25
Practice Bulletin No. 183 Summary: Postpartum Hemorrhage. 61
28937566 2017
26
Practice Bulletin No. 183: Postpartum Hemorrhage. 61
28937571 2017
27
[Atypical and rare cardiac revelation about Sheehan's syndrome: A report of three cases]. 61
28129900 2017
28
A case of stiff-person syndrome due to secondary adrenal insufficiency. 61
28552871 2017
29
Refractory hypotension induced by Sheehan syndrome with pituitary crisis: A case report. 61
28565814 2017
30
Psychiatric and Neurocognitive Manifestations of Sheehan Syndrome: A Case Report. 61
28234440 2017
31
Pitfall in the Diagnosis of Diabetes Insipidus and Pregnancy. 61
28819576 2017
32
Sheehan syndrome. 61
28004658 2016
33
Imaging of Neurologic Conditions in Pregnant Patients. 61
27831835 2016
34
CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY. 61
27359291 2016
35
Chronic Sheehan syndrome presenting as pseudo-hypertrophic myopathy (Hoffman syndrome): A very rare combination. 61
27147175 2016
36
[Neurological Disorders and Pregnancy]. 61
26953551 2016
37
Demographic study of pituitary adenomas undergone trans-sphenoidal surgery in Loghman Hakim Hospital, Tehran, Iran 2001-2013. 61
26693430 2015
38
[Nesidioblastosis in the adult: a case report]. 61
26118781 2015
39
[Psychotic Disorder and Sheehan's Syndrome: Etiology or Comorbidity?: A Case Report]. 61
26111291 2015
40
Long-standing undiagnosed sheehan syndrome presenting as polymorphic and monomorphic ventricular tachycardia: a case series of 2 patients. 61
25100393 2014
41
Sheehan syndrome: acute presentation with severe headache. 61
25223643 2014
42
[Post anoxia impairment of autobiographical memory and time estimation]. 61
24933671 2014
43
Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome. 61
24842349 2014
44
Evaluation of obstetrical factors related to Sheehan syndrome. 61
23945005 2014
45
Rifampicin induced adrenal crisis in an uncommon setting. 61
24339502 2013
46
Sheehan syndrome associated with raised intracranial pressure. 61
22790666 2013
47
A ray of hope for a woman with Sheehan's syndrome. 61
23386498 2013
48
Repairing a "broken heart" with hormone replacement therapy: case report of cardiogenic shock due to undiagnosed pituitary insufficiency. 61
22138080 2012
49
Teaching neuroimages: sequential MRI of the pituitary in Sheehan syndrome. 61
22201118 2012
50
Sheehan's syndrome: Newer advances. 61
22029025 2011
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Variations for Sheehan Syndrome

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Expression for Sheehan Syndrome

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Search GEO for disease gene expression data for Sheehan Syndrome.
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Pathways for Sheehan Syndrome

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Pathways related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 65
Show member pathways
 13.02 TRH PRL POMC GHRH CRH AVP
3
Peptide hormone metabolism 65
Show member pathways
 11.76 POMC INS IGF1
4
G alpha (s) signalling events 65
11.42 POMC GHRH CRH AVP
5
Aldosterone-regulated sodium reabsorption 36
11 INS IGF1
6
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 10.85 TRH POMC
7
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.1 PRL POMC INS
8
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10 POMC CRH
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GO Terms for Sheehan Syndrome

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Cellular components related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 PRL POMC INS IGF1 GHRH CRH
2 secretory granule GO:0030141 9.33 TRH POMC AVP
3 endosome lumen GO:0031904 9.26 PRL INS
4 extracellular region GO:0005576 9.23 TRH PRL POMC INS IGF1 GHRH

Biological processes related to Sheehan Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.91 TRH PRL POMC INS IGF1 CRH
2 positive regulation of gene expression GO:0010628 9.81 INS IGF1 CRH AVP
3 cellular protein metabolic process GO:0044267 9.75 PRL INS IGF1
4 G protein-coupled receptor signaling pathway GO:0007186 9.73 TRH POMC INS GHRH CRH AVP
5 response to ethanol GO:0045471 9.61 TRH CRH AVP
6 activation of protein kinase B activity GO:0032148 9.57 INS IGF1
7 positive regulation of mitotic nuclear division GO:0045840 9.56 INS IGF1
8 pituitary gland development GO:0021983 9.55 PROP1 HESX1
9 regulation of multicellular organism growth GO:0040014 9.54 PRL IGF1
10 positive regulation of glycolytic process GO:0045821 9.52 INS IGF1
11 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.49 IGF1 AVP
12 response to corticosterone GO:0051412 9.48 TRH CRH
13 positive regulation of glycogen biosynthetic process GO:0045725 9.46 INS IGF1
14 positive regulation of cell proliferation GO:0008284 9.43 PRL INS IGF1 GHRH CRH AVP
15 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.4 IGF1 GHRH
16 ERK1 and ERK2 cascade GO:0070371 9.33 IGF1 HESX1 AVP
17 negative regulation of feeding behavior GO:2000252 9.32 TRH INS
18 cell-cell signaling GO:0007267 9.02 TRH POMC INS GHRH AVP

Molecular functions related to Sheehan Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.26 INS IGF1
2 hormone activity GO:0005179 9.23 TRH PRL POMC INS IGF1 GHRH
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS IGF1
4 neuropeptide hormone activity GO:0005184 9.13 GHRH CRH AVP
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Sources for Sheehan Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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