MCID: SHG001
MIFTS: 58

Shigellosis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Shigellosis

MalaCards integrated aliases for Shigellosis:

Name: Shigellosis 12 76 53 59 55 3 15
Dysentery, Bacillary 44 73
Shigella Flexneri Infectious Disease 12
Shigella Boydii Infectious Disease 12
Shigella Sonnei Infectious Disease 12
Shigella Gastroenteritis 12
Bacillary Dysentery 12
Shigella Infections 73

Characteristics:

Orphanet epidemiological data:

59
shigellosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12385
MeSH 44 D004405
Orphanet 59 ORPHA810
ICD10 via Orphanet 34 A03.8 A03.9 A03.0 more
UMLS via Orphanet 74 C0013371

Summaries for Shigellosis

NIH Rare Diseases : 53 Shigellosis is a disease caused by a group of bacteria called Shigella. Shigella is very contagious. Shigella germs are present in the stools of infected individuals for up to two weeks after symptoms have resolved. Individuals may be exposed through direct contact with an infected person or through contaminated food, water (both drinking and recreational water), or surfaces. Though anyone can get shigellosis, young children are most at risk. Symptoms of shigellosis usually begin one to two days after exposure and include diarrhea, abdominal pain, and fever. In otherwise healthy individuals, the symptoms usually resolve in 5-7 days. Those with mild shigellosis may need only rest and self-care measures to avoid dehydration (drinking fluids and electrolyte solutions). For more severe cases, antibiotics may be prescribed though some cases of shigellosis have been found to be resistant to antibiotics. Laboratory tests can be performed to determine which antibiotics are likely to be effective in an individual case. Most people make a full recovery, though it may take several months for bowel habits to return to normal. Complications are rare but may include post-infectious arthritis, bloodstream infections, seizures, or hemolytic-uremic syndrome (HUS).

MalaCards based summary : Shigellosis, also known as dysentery, bacillary, is related to chlamydia and meningitis. An important gene associated with Shigellosis is CASP1 (Caspase 1), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and t cells, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in Shigella boydii, has material basis in Shigella dysenteriae, has material basis in Shigella flexneri, or has material basis in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted by ingestion of food and water contaminated with feces.

CDC : 3 Shigellosis is an infectious disease caused by a group of bacteria called Shigella (shih-GEHL-uh). Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. Shigellosis usually resolves in 5 to 7 days. Some people who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others. The spread of Shigella can be stopped by frequent and careful handwashing with soap and taking other hygiene measures.

Wikipedia : 76 Shigellosis is an infection of the intestines caused by Shigella bacteria. Symptoms generally start one... more...

Related Diseases for Shigellosis

Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 chlamydia 29.7 CASP1 CXCL8 IL10
2 meningitis 29.4 CXCL8 IL10 IRAK4
3 salmonellosis 10.5
4 dysentery 10.4
5 cholera 10.3
6 paratyphoid fever 10.2
7 hemolytic-uremic syndrome 10.2
8 diarrhea 10.2
9 encephalopathy 10.2
10 israeli tick typhus 10.2 CASP1 CXCL8
11 streptococcal toxic-shock syndrome 10.1 CXCL8 LTA
12 amebiasis 10.1
13 tungiasis 10.1 CXCL8 IL10
14 acute transverse myelitis 10.1 CXCL8 IL10
15 vulvovaginitis 10.1 CXCL8 IL10
16 scabies 10.1 CXCL8 IL10
17 neurosyphilis 10.1 CXCL8 IL10
18 wiskott-aldrich syndrome 10.1 CDC42 CTTN SRC
19 necatoriasis 10.1 CXCL8 IL10
20 mycobacterium marinum 10.1 CAMP CXCL8
21 ulcerative colitis 10.1
22 ureteral obstruction 10.1
23 noma 10.1
24 felty syndrome 10.1 CXCL8 LTF
25 typhoid fever 10.1
26 trichuriasis 10.1 CXCL8 IL10
27 giant papillary conjunctivitis 10.1 CXCL8 LTF
28 funisitis 10.1 CXCL8 IL10
29 transient hypogammaglobulinemia 10.0 IL10 LTA
30 haemophilus influenzae 10.0 CXCL8 LTF
31 clostridium difficile colitis 10.0 CDC42 LTF
32 hepatitis 10.0
33 appendicitis 10.0
34 keratoconjunctivitis 10.0
35 arthritis 10.0
36 reactive arthritis 10.0
37 clonorchiasis 10.0 CXCL8 IL10
38 idiopathic achalasia 10.0 IL10 LTA
39 toxic shock syndrome 10.0 CXCL8 IL10 LTA
40 retinitis pigmentosa 44 10.0 CXCL8 IL10
41 pouchitis 9.9 CXCL8 IL10 LTF
42 aseptic meningitis 9.9 CXCL8 IL10 LTF
43 aggressive periodontitis 9.9 CXCL8 IL10 LTF
44 malaria 9.9
45 acute diarrhea 9.9
46 brugada syndrome 9.9
47 brucellosis 9.9
48 megacolon 9.9
49 listeriosis 9.9
50 hepatitis a 9.9

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to Shigellosis

Symptoms & Phenotypes for Shigellosis

MGI Mouse Phenotypes related to Shigellosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 BTRC CASP1 CRK CTTN IL10 LTA
2 cellular MP:0005384 10.02 BTRC CAMP CASP1 CTTN IL10 IRAK4
3 hematopoietic system MP:0005397 9.85 BTRC CAMP CASP1 CTTN IL10 IRAK4
4 digestive/alimentary MP:0005381 9.73 BTRC CASP1 CRK IL10 TTR VCL
5 immune system MP:0005387 9.65 BTRC CAMP CASP1 CTTN IL10 IRAK4
6 mortality/aging MP:0010768 9.32 BTRC CAMP CASP1 CRK CTTN IL10

Drugs & Therapeutics for Shigellosis

Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular Phase 4,Phase 2,Not Applicable
2 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Acidophilus Phase 4,Not Applicable
5
Zinc Approved, Investigational Phase 3 7440-66-6
6
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173
7
Azithromycin Approved Phase 2, Phase 3 83905-01-5 55185 447043
8 Antibodies Phase 3
9 Immunoglobulins Phase 3
10 Vaccines Phase 3,Phase 2,Phase 1,Not Applicable
11 Immunologic Factors Phase 3,Phase 2,Phase 1
12 Micronutrients Phase 3
13 Trace Elements Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 3
15 Gastrointestinal Agents Phase 3,Phase 1
16 Rifamycins Phase 3
17 rifamycin SV Phase 3
18 Shiga Toxins Phase 3
19
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
20
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
21 Pharmaceutical Solutions Phase 2
22 Neurotransmitter Agents Phase 2
23
Histamine Phosphate Phase 2 51-74-1 65513
24 Histamine Antagonists Phase 2
25
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
26
Aluminum sulfate Approved Phase 1 10043-01-3
27 Anti-Ulcer Agents Phase 1
28 Adjuvants, Immunologic Phase 1
29 Antacids Phase 1
30
Formaldehyde Approved, Vet_approved 50-00-0 712
31 Disinfectants ,Not Applicable
32 Ether
33 Antitubercular Agents Not Applicable
34 Bifidobacterium Not Applicable
35 Complement System Proteins

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Lactobacillus Reuteri DSM 17938 in the Prevention of Antibiotic-associated Diarrhea in Children: Protocol of a Randomized Controlled Trial Completed NCT02871908 Phase 4 Lactobacillus reuteri DSM 17938;Placebo
2 Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in Israel Completed NCT00368316 Phase 3
3 Zinc Supplementation in Shigella Patients Completed NCT00321126 Phase 3 Children in the zinc group received 20 mg of elemental zinc as acetate per day in a twice-daily dose for two weeks.
4 Rifaximin for Prevention of Travellers' Diarrhea Completed NCT00742469 Phase 3 Rifaximin;Placebo
5 A Study to Evaluate the Efficacy, Safety and Immunogenicity of a Vaccine Designed to Protect Against Infection With Shigella Sonnei in Healthy Adults Recruiting NCT03527173 Phase 2, Phase 3 GAHB-Placebo
6 Improvements Through the Use of a Rapid Multiplex PCR Enteric Pathogen Detection Kit in Children With Hematochezia Recruiting NCT03362970 Phase 3
7 Protein Plus: Improving Infant Growth Through Diet and Enteric Health Recruiting NCT03683667 Phase 2, Phase 3 Azithromycin Oral Product;Placebos
8 Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of Protection Completed NCT00485134 Phase 1, Phase 2
9 Therapeutic Induction of Endogenous Antibiotics Completed NCT00800930 Phase 2
10 Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a Completed NCT02646371 Phase 2
11 A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan Adults Completed NCT02676895 Phase 2
12 Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine Candidate Completed NCT01080716 Phase 1, Phase 2
13 Healthy Adult Volunteer Study for Two Doses of a Shigella Vaccine Completed NCT00210288 Phase 2
14 Efficacy and Immunogenicity of Norovirus GI.1/GII.4 Bivalent Virus-like Particle Vaccine in Adults Completed NCT02669121 Phase 2
15 Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIb Terminated NCT00866242 Phase 2
16 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa Terminated NCT00866476 Phase 2
17 Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults Withdrawn NCT03038243 Phase 2
18 Shigella Sonnel O-SPC/rBRU Conjugate Vaccine Completed NCT01369927 Phase 1
19 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMP Completed NCT01531530 Phase 1
20 Shigella Sonnei 53G Challenge Completed NCT02816346 Phase 1
21 A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults. Completed NCT02017899 Phase 1
22 Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy Adults Completed NCT02034500 Phase 1
23 Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults Completed NCT01509846 Phase 1
24 Safety and Reactogenicity of Bioconjugate Vaccine to Prevent Shigella Completed NCT01069471 Phase 1
25 Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3 Completed NCT01336699 Phase 1
26 Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2a Completed NCT02388009 Phase 1
27 A Study to Evaluate Safety and Immunogenicity of 1 Booster Dose of 1790GAHB Vaccine in Healthy Adults Primed With 3 Doses of 1790GAHB Vaccine in Study H03_01TP Compared to 1 Vaccination of 1790GAHB in Either Subjects Who Received Placebo in the Same Study or naïve Subjects Not Part of H03_01TP Study Completed NCT03089879 Phase 1
28 Shigella WRSS1 Vaccine Trial in Bangladesh Completed NCT02934178 Phase 1
29 Invaplex 50 Vaccine Dose-Ranging Completed NCT00082069 Phase 1
30 SF2a-TT15 Conjugate Vaccine in Healthy Adult Volunteers Completed NCT02797236 Phase 1
31 Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota. Completed NCT01897649 Phase 1
32 Phase 1 Study of dmLT ID Vaccination in Healthy Adults Recruiting NCT02531685 Phase 1
33 Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult Volunteers Active, not recruiting NCT02445963 Phase 1
34 Shigella Sonnei OSPC-rDT Conjugate Vaccine Withdrawn NCT01399424 Phase 1 CP
35 Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli Infections Unknown status NCT01638039 Not Applicable
36 A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty Hospitals Unknown status NCT01612572
37 Experimental Phage Therapy of Bacterial Infections Unknown status NCT00945087 Not Applicable
38 The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up Study Completed NCT02516683
39 Safety Study of Live Shigella Vaccine in Bangladeshi Adults and Children Completed NCT01813071 Not Applicable
40 Evaluation of a Diagnostic Enteric Card for Management of Diarrhea Completed NCT00736567
41 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
42 Multidrug Resistant Shigella Infection in Bangladesh Recruiting NCT03778125
43 SaniVac Trial - Sanitation and Oral Rotavirus Vaccine Performance Recruiting NCT03313128
44 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814
45 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
46 The Effect of an Urban Sanitation Intervention on Child Health Recruiting NCT02362932 Not Applicable
47 The Effect of a Multispecies Probiotic on Reducing the Incidence of Antibiotic-associated Diarrhoea in Children. Recruiting NCT03334604 Not Applicable
48 Complement 2: Blood Donations to Develop Vaccines Against Infectious Diseases Recruiting NCT01945307
49 COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk) Recruiting NCT02839317
50 Determination of the Aetiologies of Acute Colitis and Early Identification of Patients Requiring Diagnostic Colonoscopy Recruiting NCT02709213

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: dysentery, bacillary

Genetic Tests for Shigellosis

Anatomical Context for Shigellosis

MalaCards organs/tissues related to Shigellosis:

41
Colon, Testes, T Cells, Brain, Kidney, Heart, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Shigellosis:

19
Epithelium Of Colon

Publications for Shigellosis

Articles related to Shigellosis:

(show top 50) (show all 836)
# Title Authors Year
1
Shigellosis and toxic megacolon secondary to Shigella flexneri serotype 3a: The challenges of laboratory diagnosis. ( 29501836 )
2018
2
An adult case with shigellosis-associated encephalopathy. ( 29351935 )
2018
3
Cyclic OmpC peptidic epitope conjugated to tetanus toxoid as a potential vaccine candidate against shigellosis. ( 29960802 )
2018
4
50 Years Ago in The Journal of Pediatrics: Comparison of Orally Absorbable and Nonabsorbable Antibiotics in Shigellosis: A Double-Blind Study with Ampicillin and Neomycin. ( 29703354 )
2018
5
Shigella (Shigellosis) ( 29493962 )
2018
6
Shigellosis outbreak among MSM living with HIV: a case-control study in Taiwan, 2015-2016. ( 29535222 )
2018
7
Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks Shigellosis, Israel. ( 29912703 )
2018
8
Heavy precipitation as a risk factor for shigellosis among homeless persons during an outbreak - Oregon, 2015-2016. ( 29217465 )
2018
9
Prediction of Shigellosis outcomes in Israel using machine learning classifiers. ( 29880081 )
2018
10
Investigating the Geographic Distribution of Shigellosis Among Men and Women in Massachusetts: Possible Implications for Men Who Have Sex With Men. ( 29420446 )
2018
11
Guidelines for the treatment of dysentery (shigellosis): a systematic review of the evidence. ( 29790845 )
2018
12
Constructing and transient expression of a gene cassette containing edible vaccine elements and shigellosis, anthrax and cholera recombinant antigens in tomato. ( 30244396 )
2018
13
Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014. ( 29415691 )
2018
14
Whole-genome sequencing revealed concurrent outbreaks of shigellosis in the English Orthodox Jewish Community caused by multiple importations of Shigella sonnei from Israel. ( 29583113 )
2018
15
50 Years Ago in The Journal of Pediatrics: Comparison of Intramuscular and Oral Ampicillin Therapy for Shigellosis. ( 30244733 )
2018
16
The Epidemiological Influence of Climatic Factors on Shigellosis Incidence Rates in Korea. ( 30309010 )
2018
17
Zinc Ameliorates Intestinal Barrier Dysfunctions in Shigellosis by Reinstating Claudin-2 and -4 on the Membranes. ( 30406698 )
2018
18
Nanonized tetracycline cures deadly diarrheal disease 'shigellosis' in mice, caused by multidrug-resistant Shigella flexneri 2a bacterial infection. ( 30448527 )
2018
19
Culture-positive shigellosis cases are epidemiologically different to culture-negative/PCR-positive cases. ( 30516310 )
2018
20
Importation of travel-related infectious diseases is increasing in South Korea: An analysis of salmonellosis, shigellosis, malaria, and dengue surveillance data. ( 28919170 )
2017
21
Protection against shigellosis caused by Shigella dysenteriae serotype 4 in guinea pigs using Escherichia albertii DM104 as a live vaccine candidate strain. ( 28597684 )
2017
22
What is the overlap between HIV and shigellosis epidemics in England: further evidence of MSM transmission? ( 28490580 )
2017
23
Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country. ( 28321350 )
2017
24
A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against<i>Shigella sonnei</i>Administered Intramuscularly to Adults from a Shigellosis-Endemic Country. ( 29375556 )
2017
25
Seasonal and geographical distribution of bacillary dysentery (shigellosis) and associated climate risk factors in Kon Tam Province in Vietnam from 1999 to 2013. ( 28637484 )
2017
26
Brugada syndrome revealed by intestinal shigellosis in a patient from Benin at the University Hospital of Saint-Etienne. ( 28944419 )
2017
27
Shigellosis. ( 29256205 )
2017
28
Double-stranded RNA induces cathelicidin expression in the intestinal epithelial cells through phosphatidylinositol 3-kinase-protein kinase CIP-Sp1 pathway and ameliorates shigellosis in mice. ( 28343946 )
2017
29
50 Years Ago in The Journal of Pediatrics: Double-Blind Treatment Study of Shigellosis Comparing Ampicillin, Sulfadiazine, and Placebo. ( 28746042 )
2017
30
An 11-year study of shigellosis and Shigella species in Taiyuan, China: Active surveillance, epidemic characteristics, and molecular serotyping. ( 28188118 )
2017
31
Shigellosis. ( 29254859 )
2017
32
An outbreak of shigellosis in a Children Welfare Institute caused by a multiple-antibiotic-resistant strain of Shigella flexneri 2a. ( 28189512 )
2017
33
Correspondence to invasive shigellosis in MSM. ( 28125923 )
2017
34
Shigellosis and Pregnancy in French Guiana: Obstetric and Neonatal Complications. ( 27114299 )
2016
35
Shigellosis in men who have sex with men: an overlooked opportunity to counsel with pre-exposure prophylaxis for HIV. ( 26945593 )
2016
36
Shigellosis. ( 27556171 )
2016
37
Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview. ( 27664045 )
2016
38
A review of the public health management of shigellosis in Australia in the era of culture-independent diagnostic testing. ( 27774718 )
2016
39
A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity. ( 26918643 )
2016
40
Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection Against Shigellosis in a Controlled Human Challenge Study. ( 27927680 )
2016
41
Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome after Shigellosis: A 10-year Follow-up Study. ( 26908484 )
2016
42
Molecular Evaluation of High Fluoroquinolone Resistant Genes in Endemic Cases of Shigellosis, Northeast Part of Karnataka, India. ( 28283137 )
2016
43
Recent Outbreaks of Shigellosis in California Caused by Two Distinct Populations of Shigella sonnei with either Increased Virulence or Fluoroquinolone Resistance. ( 28028547 )
2016
44
True Prevalence of Shigellosis in Indian Children with Acute Gastroenteritis: Have We Been Missing the Diagnosis? ( 27061990 )
2016
45
Shigellosis in Nepal: 13A years review of nationwide surveillance. ( 27814742 )
2016
46
Molecular Characterization of Shigella sonnei: An Increasingly Prevalent Etiologic Agent of Shigellosis in Guizhou Province, Southwest of China. ( 27195892 )
2016
47
Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigellosis and typhoid fever. ( 27803169 )
2016
48
Shigellosis: Epidemiology in India. ( 27487999 )
2016
49
Shigellosis: high rates of antibiotic resistance necessitate new treatment recommendations. ( 27078594 )
2016
50
Notes from the Field: Shigellosis Outbreak Among Men Who Have Sex with Men and Homeless Persons - Oregon, 2015-2016. ( 27513523 )
2016

Variations for Shigellosis

Expression for Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for Shigellosis

Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CDC42 CRK CXCL8 IL10 IRAK4 LTA
2
Show member pathways
13.56 BTRC CAMP CASP1 CDC42 CRK CXCL8
3
Show member pathways
13.3 CDC42 CXCL8 IL10 IRAK4 LTA SRC
4
Show member pathways
13.29 CDC42 CRK CXCL8 PFN1 SRC VCL
5
Show member pathways
13.08 BTRC CASP1 CRK CXCL8 IL10 IRAK4
6
Show member pathways
13.04 CASP1 CDC42 CRK CXCL8 IL10 LTA
7
Show member pathways
12.94 BTRC CRK CXCL8 IRAK4 SRC
8
Show member pathways
12.9 CAMP CASP1 CXCL8 IL10 IRAK4
9
Show member pathways
12.81 BTRC CASP1 CDC42 CRK LTA SRC
10
Show member pathways
12.69 CDC42 CRK CTTN PFN1 SRC
11
Show member pathways
12.63 CDC42 CRK PFN1 SRC
12
Show member pathways
12.61 CDC42 CRK IRAK4 SRC
13
Show member pathways
12.55 CDC42 CTTN SRC VCL
14
Show member pathways
12.52 CASP1 IRAK4 LTA SRC
15
Show member pathways
12.48 CDC42 CRK PFN1 SRC VCL
16 12.46 CDC42 CRK PFN1 SRC VCL
17
Show member pathways
12.43 CDC42 CTTN PFN1 SRC
18 12.43 CDC42 CTTN PFN1 VCL
19
Show member pathways
12.33 CDC42 CRK IRAK4 SRC
20
Show member pathways
12.3 CDC42 CRK SRC VCL
21 12.09 CAMP IL10 IRAK4 SRC
22 11.97 BTRC CDC42 SRC
23
Show member pathways
11.97 CASP1 CXCL8 IL10 SRC
24
Show member pathways
11.89 CDC42 CRK SRC
25 11.79 CXCL8 IL10 VCL
26 11.78 CXCL8 IRAK4 LTA
27
Show member pathways
11.76 CDC42 SRC VCL
28 11.69 CASP1 CDC42 CXCL8 PFN1
29 11.64 CDC42 SRC VCL
30 11.59 CDC42 IRAK4 SRC
31 11.59 CASP1 CXCL8 IL10 IRAK4
32 11.58 CRK CXCL8 SRC
33 11.52 CDC42 CTTN SRC
34 11.48 CRK SRC VCL
35 11.46 CDC42 CRK SRC
36 11.29 CDC42 CTTN SRC
37 11.22 CDC42 CRK CTTN SRC VCL
38 11.08 CDC42 CRK CTTN SRC
39 11.05 CDC42 CRK SRC
40 11.04 BTRC CDC42 CRK CTTN CXCL8 PFN1
41 10.84 CTTN CXCL8 SRC
42 10.79 BTRC SRC

GO Terms for Shigellosis

Cellular components related to Shigellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 CAMP CXCL8 IL10 IRAK4 LTA LTF
2 extracellular exosome GO:0070062 9.86 CAMP CDC42 CRK LTF PFN1 SRC
3 focal adhesion GO:0005925 9.73 CDC42 CTTN PFN1 VCL
4 cell cortex GO:0005938 9.63 CDC42 CTTN PFN1
5 protein-containing complex GO:0032991 9.43 CASP1 CDC42 CRK LTF TTR VCL
6 specific granule GO:0042581 9.37 CAMP LTF
7 specific granule lumen GO:0035580 9.33 CAMP LTF VCL
8 podosome GO:0002102 8.8 CTTN SRC VCL
9 cytoplasm GO:0005737 10.1 BTRC CAMP CASP1 CDC42 CRK CTTN

Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.65 CDC42 CRK SRC
2 cytokine-mediated signaling pathway GO:0019221 9.55 CASP1 CRK CXCL8 IL10 IRAK4
3 ephrin receptor signaling pathway GO:0048013 9.54 CDC42 CRK SRC
4 innate immune response in mucosa GO:0002227 9.52 CAMP LTF
5 leukocyte chemotaxis GO:0030595 9.51 CXCL8 IL10
6 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.5 CAMP CXCL8 LTF
7 regulation of protein binding GO:0043393 9.49 CRK SRC
8 positive regulation of smooth muscle cell migration GO:0014911 9.46 CRK SRC
9 branching involved in mammary gland duct morphogenesis GO:0060444 9.43 BTRC SRC
10 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.43 CDC42 CRK SRC
11 response to molecule of bacterial origin GO:0002237 9.4 CXCL8 IL10
12 negative regulation of growth of symbiont in host GO:0044130 9.13 CAMP IL10 LTA
13 cellular response to lipopolysaccharide GO:0071222 9.02 CAMP CASP1 CXCL8 IL10 SRC

Molecular functions related to Shigellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.26 CTTN PFN1 SRC VCL
2 protein phosphorylated amino acid binding GO:0045309 8.62 BTRC CRK

Sources for Shigellosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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