EKC
MCID: SHP001
MIFTS: 31

Shipyard Eye (EKC)

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Shipyard Eye

MalaCards integrated aliases for Shipyard Eye:

Name: Shipyard Eye 12 15
Epidemic Keratoconjunctivitis 12 54 70
Ekc 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13014
ICD9CM 34 077.1
NCIt 50 C34590
SNOMED-CT 67 60548004
ICD10 32 B30.0
UMLS 70 C0014493

Summaries for Shipyard Eye

MalaCards based summary : Shipyard Eye, also known as epidemic keratoconjunctivitis, is related to acute hemorrhagic conjunctivitis and acute conjunctivitis. An important gene associated with Shipyard Eye is CXADR (CXADR Ig-Like Cell Adhesion Molecule). The drugs Povidone and Povidone-iodine have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and endothelial.

Related Diseases for Shipyard Eye

Diseases related to Shipyard Eye via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 acute hemorrhagic conjunctivitis 30.7 PSEN2 MINK1
2 acute conjunctivitis 30.5 PSEN2 PLD3
3 pharyngoconjunctival fever 30.1 PSEN2 CXADR CD46
4 conjunctival folliculosis 29.6 PSEN2 MINK1 CD46 ADCY10
5 erythrokeratodermia-cardiomyopathy syndrome 11.0
6 st. louis encephalitis 10.2
7 encephalitis 10.2
8 ocular motor apraxia 10.1
9 astigmatism 10.1
10 alzheimer disease 19 10.1
11 ifap syndrome 2 10.1
12 ptosis 10.1
13 herpes simplex 10.1
14 keratoconjunctivitis 10.1
15 hair whorl 10.1
16 keratitis, hereditary 10.1
17 disease by infectious agent 10.1
18 keratoconus 10.1
19 corneal edema 10.1
20 orbital cellulitis 10.1
21 optic neuritis 10.1
22 lymphocytic choriomeningitis 10.1
23 irregular astigmatism 10.1
24 neuritis 10.1
25 cellulitis 10.1
26 corneal ulcer 10.1
27 retinitis pigmentosa 47 10.0 PSEN2 ADCY10
28 monkeypox 9.9 CRYGC CD46
29 aging 9.9
30 eye disease 9.9
31 conjunctivitis 9.9
32 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 9.9 PSEN2 PLD3
33 lacrimal duct defect 9.9
34 strabismus 9.9
35 suppressor of tumorigenicity 3 9.9
36 alzheimer disease 15 9.9
37 alzheimer disease 17 9.9
38 herpes simplex virus keratitis 9.9
39 suppression amblyopia 9.9
40 amblyopia 9.9
41 pseudomembranous conjunctivitis 9.9
42 myopia 9.9
43 superficial keratitis 9.9
44 iritis 9.9
45 optic nerve disease 9.9
46 keratopathy 9.9
47 papillary conjunctivitis 9.9
48 newcastle disease 9.9
49 cataract 9.9
50 neuropathy 9.9

Graphical network of the top 20 diseases related to Shipyard Eye:



Diseases related to Shipyard Eye

Symptoms & Phenotypes for Shipyard Eye

Drugs & Therapeutics for Shipyard Eye

Drugs for Shipyard Eye (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved Phase 4 9003-39-8 131751496
2
Povidone-iodine Approved Phase 4 25655-41-8
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
5
Fluorometholone Approved, Investigational Phase 4 426-13-1 9878
6
Iron Approved Phase 4 7439-89-6 23925 29936
7
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
8
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 4 8001-79-4
9
Cadexomer iodine Experimental Phase 4 94820-09-4
10 Trace Elements Phase 4
11 Nutrients Phase 4
12 Anti-Infective Agents, Local Phase 4
13 Anti-Infective Agents Phase 4
14 Plasma Substitutes Phase 4
15 Micronutrients Phase 4
16 Blood Substitutes Phase 4
17 Pharmaceutical Solutions Phase 4
18 Castor Phase 4
19 Ophthalmic Solutions Phase 4
20 glucocorticoids Phase 4
21 Hormone Antagonists Phase 4
22 Immunosuppressive Agents Phase 4
23 Antirheumatic Agents Phase 4
24 Immunologic Factors Phase 4
25 Hormones Phase 4
26 Cyclosporins Phase 4
27 Dermatologic Agents Phase 4
28 Antifungal Agents Phase 4
29 Anti-Allergic Agents Phase 4
30 Calcineurin Inhibitors Phase 4
31 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4 2% povidone-iodine;2% povidone-iodine
2 Treatment of Subepithelial Infiltrates Secondary to Epidemic Keratoconjunctivitis: Corticosteroids Versus Cyclosporine Eyedrops: A Randomized Double-blind Study Completed NCT04376970 Phase 4 FLUCON®;Cyclosporine A eye drops 0.5%
3 Evaluation of the Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Acute Phase Adenoviral-Induced Epidemic Keratoconjunctivitis (EKC). A Randomised, Double-Masked, Placebo-Controlled, Multi-Centre Proof-of-Concept Study Completed NCT01977443 Phase 2 APD-209 Eye drops;APD-209 Placebo Eye drops
4 Povidone Iodine 5% Eye Wash in Treatment of Epidemic Keratoconjunctivitis Completed NCT04169919 Povidone-Iodine;Normal Saline Flush

Search NIH Clinical Center for Shipyard Eye

Genetic Tests for Shipyard Eye

Anatomical Context for Shipyard Eye

MalaCards organs/tissues related to Shipyard Eye:

40
Eye, Liver, Endothelial, Neutrophil

Publications for Shipyard Eye

Articles related to Shipyard Eye:

(show top 50) (show all 554)
# Title Authors PMID Year
1
Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis. 54 61
15047806 2004
2
Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction. 54 61
12429514 2002
3
Cost Savings From a Policy to Diagnose and Prevent Transmission of Adenoviral Conjunctivitis in Employees of a Large Academic Medical Center. 61
33792644 2021
4
Ocular Anterior Segment Pathology in the Emergency Department: A 5-Year Study. 61
32568931 2021
5
Chemical disinfectants in ophthalmic practice. 61
33595464 2021
6
Visual rehabilitation by using corneal wavefront-guided transepithelial photorefractive keratectomy for corneal opacities after epidemic keratoconjunctivitis. 61
33730316 2021
7
Whole-genome analysis to describe a human adenovirus D8 conjunctivitis outbreak in a tertiary hospital. 61
33543795 2021
8
Two cases of epidemic keratoconjunctivitis-associated dacryocystitis. 61
31852315 2020
9
Unilateral upper eyelid eversion and kink associated with epidemic keratoconjunctivitis. 61
32875156 2020
10
Epidemic keratoconjunctivitis in India: electronic medical records-driven big data analytics report IV. 61
33229346 2020
11
Adverse Events of Intense Pulsed Light Combined With Meibomian Gland Expression Versus Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction. 61
33161597 2020
12
Corticosteroids Versus Cyclosporine for Subepithelial Infiltrates Secondary to Epidemic Keratoconjunctivitis: A Prospective Randomized Double-Blind Study. 61
33201059 2020
13
A treatment protocol for minimizing duration and complications of adenoviral epidemic keratoconjunctivitis. 61
33437600 2020
14
Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37-Viruses That Cause Highly Contagious Eye Infections. 61
32845119 2020
15
Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients. 61
33075208 2020
16
The Impact of Bilateral Subepithelial Corneal Infiltrates on Tear Film After Epidemic Keratoconjunctivitis. 61
31794540 2020
17
Correlation between corneal involvement and anterior chamber flare in epidemic keratoconjunctivitis. 61
31111724 2020
18
Evaluation of the Anti-Adenoviral Activity of ALTANT, an Ozonated Alcohol Disinfectant. 61
32350225 2020
19
[Outbreak of epidemic keratoconjunctivitis caused by human adenovirus serotype 8 in a nursing home.] 61
32896840 2020
20
Entry of Epidemic Keratoconjunctivitis-Associated Human Adenovirus Type 37 in Human Corneal Epithelial Cells. 61
32852546 2020
21
Five Cases of Epidemic Keratoconjunctivitis Due to Human Adenovirus Type 85 in Fukushima, Japan. 61
32350223 2020
22
[Progress in engineering application of human adenovirus]. 61
32748584 2020
23
Characteristic of slow growth in cell culture of adenovirus type 54 causing nationwide outbreak epidemic keratoconjunctivitis in Japan. 61
32125553 2020
24
Epidemic Keratoconjunctivitis in India: Trend Analysis and Implications for Viral Outbreaks. 61
32317436 2020
25
Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis. 61
31891773 2020
26
Hand hygiene and instrument sanitization in ophthalmology clinics. 61
31770164 2020
27
Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir. 61
32345035 2020
28
Transepithelial Surface Ablation With Mitomycin C for the Treatment of Chronic Central Corneal Scars Following Adenoviral Keratoconjunctivitis. 61
31917852 2020
29
Management of Adenoviral Keratoconjunctivitis: Challenges and Solutions. 61
32256043 2020
30
Understanding Infection Prevention Practices in Optometry Clinics. 61
31895274 2020
31
A 8-year retrospective clinical analysis of 272 patients of epidemic Keratoconjunctivitis in Beijing, China. 61
31856790 2019
32
Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014. 61
31607514 2019
33
[Genetic characteristics of five human adenovirus type 53 strains isolated from Taiyuan city in 2016, China]. 61
31795585 2019
34
Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate. 61
31813297 2019
35
Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D. 61
31769017 2019
36
Conjunctivitis Due to the Human Adenovirus Type 2 Variant Identified during Epidemic Keratoconjunctivitis Surveillance in Japan. 61
31366858 2019
37
Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor. 61
31517055 2019
38
Chlamydia trachomatis presenting as preseptal cellulitis in a 3-year-old girl. 61
31112775 2019
39
[Detection and Molecular Characterization of Human Adenoviruses from Acute Conjunctivitis Cases]. 61
31414631 2019
40
An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China. 61
31307413 2019
41
Sialic Acid-Containing Glycans as Cellular Receptors for Ocular Human Adenoviruses: Implications for Tropism and Treatment. 61
31035532 2019
42
Frequency of adenovirus serotype 8 in patients with Keratoconjunctivitis, in Ahvaz, Iran. 61
31341567 2019
43
Sulfated Glycosaminoglycans as Viral Decoy Receptors for Human Adenovirus Type 37. 61
30871026 2019
44
Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus. 61
30870979 2019
45
Challenges in management of epidemic keratoconjunctivitis with emerging recombinant human adenoviruses. 61
30654207 2019
46
The effect of corneal infiltrates on densitometry and higher-order aberrations. 61
30107640 2019
47
Human adenoviral type 54 keratoconjunctivitis accompanied by stellate keratitis and keratic precipitates: two cases. 61
30616635 2019
48
In Vivo Confocal Microscopy Analysis of the Corneal Layers in Adenoviral Epidemic Keratoconjunctivitis 61
30605932 2018
49
Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017. 61
30521501 2018
50
Investigation of the efficacy of alcohol-based solutions on adenovirus serotypes 8, 19 and 37, common causes of epidemic keratoconjunctivitis, after an adenovirus outbreak in hospital. 61
29792970 2018

Variations for Shipyard Eye

Expression for Shipyard Eye

Search GEO for disease gene expression data for Shipyard Eye.

Pathways for Shipyard Eye

GO Terms for Shipyard Eye

Cellular components related to Shipyard Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.43 RIT2 PSEN2 CXADR
2 intercalated disc GO:0014704 9.16 DSG2 CXADR
3 growth cone GO:0030426 9.13 PSEN2 CXADR ADCY10
4 apical plasma membrane GO:0016324 8.92 PSEN2 DSG2 AP2A1 ADCY10

Sources for Shipyard Eye

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....