EKC
MCID: SHP001
MIFTS: 36

Shipyard Eye (EKC)

Categories: Eye diseases

Aliases & Classifications for Shipyard Eye

MalaCards integrated aliases for Shipyard Eye:

Name: Shipyard Eye 12 15
Epidemic Keratoconjunctivitis 12 55 73
Ekc 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13014
ICD10 33 B30.0
ICD9CM 35 077.1
NCIt 50 C34590
SNOMED-CT 68 60548004
UMLS 73 C0014493

Summaries for Shipyard Eye

MalaCards based summary : Shipyard Eye, also known as epidemic keratoconjunctivitis, is related to acute hemorrhagic conjunctivitis and erythrokeratodermia-cardiomyopathy syndrome. An important gene associated with Shipyard Eye is CD46 (CD46 Molecule), and among its related pathways/superpathways are Notch signaling pathway (KEGG) and Wnt / Hedgehog / Notch. The drugs Povidone and Iodine have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Shipyard Eye

Graphical network of the top 20 diseases related to Shipyard Eye:



Diseases related to Shipyard Eye

Symptoms & Phenotypes for Shipyard Eye

GenomeRNAi Phenotypes related to Shipyard Eye according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.44 TP53RK
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 TP53RK
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.44 OSGEP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 TP53RK
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.44 OSGEP TP53RK
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.44 CD46
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 CD46 OSGEP TP53RK
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.44 CD46
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.44 TP53RK
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-64 9.44 CD46

Drugs & Therapeutics for Shipyard Eye

Drugs for Shipyard Eye (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved Phase 4 9003-39-8
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Povidone-iodine Approved Phase 4 25655-41-8
4 Plasma Substitutes Phase 4
5 Anti-Infective Agents Phase 4
6 Micronutrients Phase 4
7 cadexomer iodine Phase 4
8 Trace Elements Phase 4
9 Anti-Infective Agents, Local Phase 4
10 Blood Substitutes Phase 4
11 Ophthalmic Solutions Phase 2
12 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4 2% povidone-iodine;2% povidone-iodine
2 Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Epidemic Keratoconjunctivitis (EKC) Completed NCT01977443 Phase 2 APD-209 Eye drops;APD-209 Placebo Eye drops

Search NIH Clinical Center for Shipyard Eye

Genetic Tests for Shipyard Eye

Anatomical Context for Shipyard Eye

MalaCards organs/tissues related to Shipyard Eye:

41
Eye, Testes

Publications for Shipyard Eye

Articles related to Shipyard Eye:

(show top 50) (show all 226)
# Title Authors Year
1
Adenovirus-related epidemic keratoconjunctivitis outbreak at a hospital-affiliated ophthalmology clinic. ( 29305276 )
2018
2
Epidemic Keratoconjunctivitis: (Superficial Punctate Keratitis, Keratitis Subepithelialis, Keratitis Maculosa, Keratitis Nummularis) With a Review of the Literature and a Report of 125A Cases. ( 29793576 )
2018
3
Epidemic keratoconjunctivitis cases resulting from adenovirus type 8 and 54 detected at Fukuoka University Hospital between 2014 and 2015. ( 29709978 )
2018
4
Recombinant type Human mastadenovirus D85 associated with epidemic keratoconjunctivitis since 2015 in Japan. ( 29396992 )
2018
5
Investigation of the efficacy of alcohol-based solutions on adenovirus serotypes 8, 19 and 37, the common cause of epidemic keratoconjunctivitis, after an adenovirus outbreak occurred in the hospital. ( 29792970 )
2018
6
Clinical and virological analysis of epidemic keratoconjunctivitis caused by adenovirus type 54 in a regional ophthalmic clinic in Kyushu, Japan. ( 29593376 )
2018
7
Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017. ( 30521501 )
2018
8
Notes from the Field: Epidemic Keratoconjunctivitis Outbreak Associated with Human Adenovirus Type 8 - U.S. Virgin Islands, June-November 2016. ( 28771460 )
2017
9
Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016. ( 28915257 )
2017
10
Changes in Higher-Order Aberrations After Phototherapeutic Keratectomy for Subepithelial Corneal Infiltrates After Epidemic Keratoconjunctivitis. ( 28742618 )
2017
11
Different Clinical Presentations of the Same Epidemic Keratoconjunctivitis Outbreak in Premature Babies and Their Parents. ( 27598721 )
2016
12
Notes from the Field: Health Care-Associated Outbreak of Epidemic Keratoconjunctivitis - West Virginia, 2015. ( 27078721 )
2016
13
Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells. ( 27303700 )
2016
14
Selection pressure in the human adenovirus fiber knob drives cell specificity in epidemic keratoconjunctivitis. ( 27512073 )
2016
15
Enhancing best practices in ophthalmology for prevention of nosocomial epidemic keratoconjunctivitis infections. ( 27376504 )
2016
16
Persistent Symblepharon in an Infant Following Epidemic Keratoconjunctivitis. ( 28293652 )
2016
17
Targeting species D adenoviruses replication to counteract the epidemic keratoconjunctivitis. ( 25796214 )
2015
18
Human adenovirus type 8 epidemic keratoconjunctivitis with large corneal epithelial full-layer detachment: an endemic outbreak with uncommon manifestations. ( 26060391 )
2015
19
More symptoms with sialic receptor-positive adenovirus in epidemic keratoconjunctivitis. ( 26523611 )
2015
20
Oral steroid therapy as an adjuvant treatment for severe epidemic keratoconjunctivitis in patients younger than 3 years. ( 25522221 )
2015
21
Evaluation of the impact of persistent subepithelial corneal infiltrations on the visual performance and corneal optical quality after epidemic keratoconjunctivitis. ( 25043311 )
2014
22
Human adenovirus type 8: the major agent of epidemic keratoconjunctivitis (EKC). ( 25464969 )
2014
23
Outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 56, china, 2012. ( 25343525 )
2014
24
Porcine corneal cell culture models for studying epidemic keratoconjunctivitis. ( 23559855 )
2013
25
Corneal sensitivity may decrease in adenoviral epidemic keratoconjunctivitis--a confocal microscopic study. ( 23719580 )
2013
26
Adenovirus-associated epidemic keratoconjunctivitis outbreaks--four states, 2008-2010. ( 23945769 )
2013
27
Epidemic keratoconjunctivitis outbreak in a closed psychiatric ward. ( 23739088 )
2013
28
Molecular epidemiology of human adenoviruses d associated with epidemic keratoconjunctivitis in Osaka, Japan, 2001-2010. ( 24047746 )
2013
29
Orbital inflammation developing from epidemic keratoconjunctivitis in an adult. ( 24019793 )
2013
30
Collect, boil and amplify--a simple approach for the detection of three common viruses associated with epidemic keratoconjunctivitis, conjunctivitis and dendritic ulcers. ( 23411346 )
2013
31
Treatment of epidemic keratoconjunctivitis with 2% povidone-iodine: a pilot study. ( 21916618 )
2012
32
A molecular epidemiologic study of human adenovirus type 8 isolates causing epidemic keratoconjunctivitis in Kawasaki City, Japan in 2011. ( 22627311 )
2012
33
Cyclosporine a 0.05% eye drops for the treatment of subepithelial infiltrates after epidemic keratoconjunctivitis. ( 22900547 )
2012
34
Surveillance of adenovirus D in patients with epidemic keratoconjunctivitis from Fukui Prefecture, Japan, 1995-2010. ( 22052618 )
2012
35
Photorefractive keratectomy with mitomycin-C for the combined treatment of myopia and subepithelial infiltrates after epidemic keratoconjunctivitis. ( 22624902 )
2012
36
Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64. ( 22467570 )
2012
37
Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan. ( 22171158 )
2011
38
Complete genome analysis of a novel intertypic recombinant human adenovirus causing epidemic keratoconjunctivitis in Japan. ( 21147954 )
2011
39
Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan. ( 20530657 )
2011
40
Outbreak of epidemic keratoconjunctivitis caused by adenovirus type 54 in a nursery school in Kobe City, Japan in 2008. ( 21788718 )
2011
41
Epidemic keratoconjunctivitis: the current situation and recommendations for prevention and treatment. ( 21814523 )
2011
42
The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis. ( 21683743 )
2011
43
Effect of the H1N1 influenza pandemic on the incidence of epidemic keratoconjunctivitis and on hygiene behavior: a cross-sectional study. ( 21858118 )
2011
44
The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. ( 21151139 )
2011
45
Amblyopia and strabismus by monocular corneal opacity following suspected epidemic keratoconjunctivitis in infancy. ( 21860573 )
2011
46
Phototherapeutic keratectomy for the treatment of corneal opacities after epidemic keratoconjunctivitis. ( 21109229 )
2011
47
Public Health adds value to an investigation of epidemic keratoconjunctivitis. ( 20648070 )
2010
48
Cellular and tissue architecture of conjunctival membranes in epidemic keratoconjunctivitis. ( 20735288 )
2010
49
An outbreak of epidemic keratoconjunctivitis at an outpatient ophthalmology clinic. ( 24470897 )
2010
50
Nucleotide sequence variation in the hexon gene of human adenovirus type 8 and 37 strains from epidemic keratoconjunctivitis patients in Japan. ( 19458172 )
2009

Variations for Shipyard Eye

Expression for Shipyard Eye

Search GEO for disease gene expression data for Shipyard Eye.

Pathways for Shipyard Eye

GO Terms for Shipyard Eye

Cellular components related to Shipyard Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.62 OSGEP TP53RK

Biological processes related to Shipyard Eye according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.43 JAG2 PSEN2 PSENEN
2 protein processing GO:0016485 9.37 PSEN2 PSENEN
3 membrane protein ectodomain proteolysis GO:0006509 9.32 PSEN2 PSENEN
4 Notch receptor processing GO:0007220 9.16 PSEN2 PSENEN
5 amyloid precursor protein catabolic process GO:0042987 8.96 PSEN2 PSENEN
6 Notch receptor processing, ligand-dependent GO:0035333 8.62 PSEN2 PSENEN

Sources for Shipyard Eye

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....