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MCID: SHL001
MIFTS: 37

Shoulder Impingement Syndrome

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Shoulder Impingement Syndrome

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MalaCards integrated aliases for Shoulder Impingement Syndrome:

Name: Shoulder Impingement Syndrome 12 44 15 73
Impingement Syndrome of Shoulder Region 12
Subacromial Impingement 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14276
ICD10 33 M75.4
MeSH 44 D019534
UMLS 73 C0376685
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Summaries for Shoulder Impingement Syndrome

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MalaCards based summary : Shoulder Impingement Syndrome, also known as impingement syndrome of shoulder region, is related to tendinitis and lipomatosis, multiple, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Shoulder Impingement Syndrome is JAG1 (Jagged 1), and among its related pathways/superpathways are Signaling pathways regulating pluripotency of stem cells and Immune response IFN gamma signaling pathway. The drugs Triamcinolone and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes and bone, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

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Related Diseases for Shoulder Impingement Syndrome

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Diseases related to Shoulder Impingement Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 tendinitis 30.1 LHB PDGFB
2 lipomatosis, multiple 10.2
3 pleomorphic lipoma 10.2
4 bursitis 10.1
5 anxiety 10.1
6 osteoarthritis 10.1
7 mononeuropathy 10.1
8 exostosis 10.1
9 hereditary multiple exostoses 10.1
10 herpes zoster 10.1
11 synovial chondromatosis 10.1
12 depression 10.1
13 paresthesia 10.1
14 whiplash 10.1
15 tendinopathy 10.0

Graphical network of the top 20 diseases related to Shoulder Impingement Syndrome:



Diseases related to Shoulder Impingement Syndrome
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Symptoms & Phenotypes for Shoulder Impingement Syndrome

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UMLS symptoms related to Shoulder Impingement Syndrome:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Shoulder Impingement Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 HFM1 JAG1 LHB SKIL ZFHX3
2 homeostasis/metabolism MP:0005376 9.43 JAG1 LHB PDGFB PPP1R3C SKIL ZFHX3
3 reproductive system MP:0005389 9.02 HFM1 LHB PDGFB SKIL ZFHX3
Sources

Drugs & Therapeutics for Shoulder Impingement Syndrome

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Drugs for Shoulder Impingement Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 124-94-7 31307
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 137-58-6 3676
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
6 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
7 glucocorticoids Phase 4,Phase 2,Not Applicable
8 Hormone Antagonists Phase 4,Phase 2,Not Applicable
9 Hormones Phase 4,Phase 2,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
11 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
12 Triamcinolone hexacetonide Phase 4,Phase 2,Not Applicable
13 Anesthetics, Local Phase 4,Phase 2,Not Applicable
14 Immunosuppressive Agents Phase 4,Phase 2,Not Applicable
15 Diuretics, Potassium Sparing Phase 4,Phase 2,Not Applicable
16 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
17 Immunologic Factors Phase 4,Phase 2,Phase 3,Not Applicable
18 Anesthetics Phase 4,Phase 2,Not Applicable
19 Sodium Channel Blockers Phase 4,Phase 2,Not Applicable
20 triamcinolone acetonide Phase 4,Phase 2,Not Applicable
21 Triamcinolone diacetate Phase 4,Phase 2,Not Applicable
22 Antiemetics Phase 4,Not Applicable
23 HIV Protease Inhibitors Phase 4
24 Gastrointestinal Agents Phase 4,Not Applicable
25
protease inhibitors Phase 4
26 Antineoplastic Agents, Hormonal Phase 4,Not Applicable
27 Autonomic Agents Phase 4,Not Applicable
28 BB 1101 Phase 4
29
Hyaluronic acid Approved, Vet_approved Phase 2, Phase 3,Not Applicable 9004-61-9 53477741
30 Adjuvants, Immunologic Phase 2, Phase 3,Not Applicable
31 Viscosupplements Phase 2, Phase 3,Not Applicable
32 Pharmaceutical Solutions Phase 2, Phase 3,Not Applicable
33 Protective Agents Phase 2, Phase 3,Not Applicable
34 Mitogens Phase 3
35
Benzyl alcohol Approved Phase 2 100-51-6 244
36
Tetracaine Approved, Vet_approved Phase 2 94-24-6 5411
37
Ethanol Approved Phase 2 64-17-5 702
38
Acetylcholine Approved Phase 2 51-84-3 187
39 Carboxymethylcellulose Sodium Phase 2
40 Acetylcholine Release Inhibitors Phase 2
41 onabotulinumtoxinA Phase 2
42 Cholinergic Agents Phase 2
43 Neurotransmitter Agents Phase 2
44 Botulinum Toxins Phase 2
45 abobotulinumtoxinA Phase 2
46 Botulinum Toxins, Type A Phase 2
47 sodium thiosulfate Phase 2
48 Anti-Bacterial Agents Phase 2
49 Antioxidants Phase 2
50 Anti-Infective Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 114)
# Name Status NCT ID Phase Drugs
1 Radio-frequency (RF)-Based Plasma Micro-tenotomy for the Treatment of Shoulder Impingement Syndrome Completed NCT01554670 Phase 4
2 Low Level Laser Therapy Associated With Exercise in Subacromial Impingement Syndrome Completed NCT02725749 Phase 4
3 Dexamethasone for Pain After Shoulder Surgery Completed NCT01414569 Phase 4 Dexamethasone
4 Combined Corticosteroid With Low Volume Compared to High Volume in Impingement Syndrome Completed NCT03120923 Phase 4 Lidocaine 3 cc;Lidocaine 9 cc;Triamcinolone Acetonide
5 Subacromial Decompression Versus Subacromial Bursectomy for Patients With Rotator Cuff Tendinosis Unknown status NCT00196573 Phase 3
6 Supervised Exercises Compared With Radial Extracorporal Shock Wave Therapy (rESWT) in Patients With SIS Unknown status NCT00653081 Phase 3
7 Radial Extracorporeal Shock Wave Therapy (rESWT) Treatment of Subacromial Shoulder Pain Unknown status NCT01441830 Phase 3
8 Ultrasonography Guided Subacromial Sodium Hyaluronate Injection in Rotator Cuff Disease Unknown status NCT01735058 Phase 2, Phase 3 Sodium Hyaluronate;Normal saline
9 The Influence of Growth Factors (PDGF), Applied as Autologous Thrombocyte Concentrate, on Functional Recovery Completed NCT01510639 Phase 3
10 Glenohumeral Re-centering During Closed Kinetic Chain for Shoulder Physiotherapy. A Prospective and Randomized Study. Recruiting NCT02874105 Phase 3
11 Pain Patch Versus Injections in the Treatment of Pain Associated With Shoulder Impingement Syndrome Unknown status NCT01544283 Phase 2 Synera® (lidocaine 70 mg and tetracaine 70 mg) topical patch;Triamcinolone Acetonide
12 Study of the Treatment of Tendinopathy Unruptured of Rotator Cuff by Intramuscular Injection of Botulinum Toxin Unknown status NCT02867787 Phase 2 Botox arm
13 Study Evaluating Heated Lidocaine/Tetracaine Topical Patch in Treatment of Patients With Shoulder Impingement Syndrome Completed NCT01055444 Phase 2 Heated lidocaine and tetracaine topical patch
14 Exercise and Manual Therapy for Shoulder Subacromial Impingement Syndrome Completed NCT00632996 Phase 2
15 Neck Mobs and Impingement Completed NCT01744002 Phase 2
16 Efficacy and Tolerance of Sodium Thiosulfate Injection After Ultrasound-guided Percutaneous Irrigation of Calcific Tendinopathy of the Rotator Cuff Completed NCT02538939 Phase 2 Sodium thiosulfate
17 Prediction Frozen Shoulder Validation Completed NCT01157221 Phase 1, Phase 2
18 Exercise Application in the Treatment of Patients With Shoulder Impingement Not yet recruiting NCT02695524 Phase 2
19 The Clinical Efficacy of Belting Stabilization for Shoulder Pain Completed NCT00826293 Phase 1
20 Study of the Effect of Neck Treatment on Shoulder Impingement Terminated NCT00764764 Phase 1
21 Conservative or Operative Treatment for the Shoulder Impingement Syndrome? Unknown status NCT00349648 Not Applicable
22 Efficacy of Electrotherapy in Subacromial Impingement Syndrome Unknown status NCT01073956 Not Applicable
23 Teres Major Muscle and Subacromial Impingement Syndrome Unknown status NCT02374125 Not Applicable
24 Exercise in the Physiotherapy Management of Shoulder Impingement Unknown status NCT01691157 Not Applicable
25 Effectiveness of Telerehabilitation Program in Subacromial Syndrome (Telerehab Sis) Unknown status NCT02909920 Not Applicable
26 Effect of Exercise Programs on 3-dimensional Scapular Kinematics, Disability and Pain Unknown status NCT02286310 Not Applicable
27 Evaluation of the Difference in the Acromion Humerus Gap at Sitting,Lying Unknown status NCT01264926
28 ArthroPlanner: A Surgical Planning Solution for Acromioplasty Unknown status NCT02725346 Not Applicable
29 Shoulder Brace on Muscle Activation and Scapular Kinematics in Patients With Shoulder Impingement Syndrome and Rounded Shoulder Posture Completed NCT03667833 Not Applicable
30 Effects of Eccentric Training for Shoulder Abductors in Subjects With Shoulder Impingement Syndrome Completed NCT01090271 Not Applicable
31 Effects of Mulligan's Technique in Subjects With Shoulder Impingement Syndrome Completed NCT02463526 Not Applicable
32 Physical Therapy Versus Steroid Injection for Shoulder Impingement Syndrome Completed NCT01190891 Not Applicable
33 Study of Neurocognitive Therapeutic Exercise in the Shoulder Impingement Syndrome in Comparison With Traditional Therapeutic Exercise Completed NCT01785745 Not Applicable
34 Standardized and Modified Corticosteroid Subacromial Injection for Shoulder Impingement Syndrome Completed NCT03148353 Not Applicable
35 Randomized Clinical Trial of Rehabilitation for Subacromial Impingement Syndrome Completed NCT00633451 Not Applicable
36 Subacromial Impingement Syndrome Approach Using High Intensity Laser Therapy Completed NCT02971215 Not Applicable
37 Progressive Resistance Training of the Biceps in Subacromial Impingement Syndrome Completed NCT01314196 Not Applicable
38 A New Shoulder Proprioceptive Rehabilitative Tool (SRPT) for the Evaluation of the Role of the Shoulder During Reaching Completed NCT02646306
39 Effects of Cryotherapy on Joint Function and Pressure Pain Threshold in Patients With Subacromial Impingement Syndrome. Completed NCT02351986 Not Applicable
40 Effects of Overload Progressive in the Treatment of Shoulder Completed NCT02870257 Not Applicable
41 Subacromial Injection of Allogeneic Platelet Rich Plasma (PRP) for Shoulder Impingement Syndrome Completed NCT02019537 Not Applicable
42 Mobilization With Movement for Shoulder Impingement Completed NCT02172079 Not Applicable
43 Comparison of the Proprioceptive Neuromuscular Facilitation and Mobilization In Subacromial Impingement Syndrome Completed NCT03735485 Not Applicable
44 Exercise Training Sequence for Subacromial Impingement Syndrome Completed NCT02478567 Not Applicable
45 Supervised Exercise Therapy vs Home Exercises for Patients With Subacromial Impingement Completed NCT01257113 Not Applicable
46 Effectiveness of Two Electrotherapy Techniques to Treat Subacromial Impingement Syndrome Completed NCT02110030 Not Applicable
47 Comparison of Exercise Interventions in Adults With Subacromial Impingement Syndrome Completed NCT01508715 Not Applicable
48 Acupuncture Treatment of Shoulder Impingement Syndrome Completed NCT02449668 Not Applicable
49 Subacute Effects of Spinal Mobilization to Treat Subacromial Impingement Completed NCT01753271 Not Applicable
50 Assessment of Thoracolumbar Fascia Length Completed NCT03415438

Search NIH Clinical Center for Shoulder Impingement Syndrome

Cochrane evidence based reviews: shoulder impingement syndrome

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Genetic Tests for Shoulder Impingement Syndrome

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Anatomical Context for Shoulder Impingement Syndrome

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MalaCards organs/tissues related to Shoulder Impingement Syndrome:

41
Testes, Bone
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Publications for Shoulder Impingement Syndrome

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Articles related to Shoulder Impingement Syndrome:

(show top 50) (show all 169)
# Title Authors Year
1
Comparison of different electrotherapy methods and exercise therapy in shoulder impingement syndrome: A prospective randomized controlled trial. ( 29703659 )
2018
2
Effects of Kinesiology Taping on Scapular Reposition Accuracy, Kinematics, and Muscle Activity in Athletes with Shoulder Impingement Syndrome - A Randomized Controlled Study. ( 29364027 )
2018
3
Comparison of Upper Trapezius and Infraspinatus Myofascial Trigger Point Therapy by Dry Needling in Overhead Athletes With Unilateral Shoulder Impingement Syndrome. ( 29364040 )
2018
4
Test-Retest Reliability of Handgrip Strength as an Outcome Measure in Patients With Symptoms of Shoulder Impingement Syndrome. ( 29549892 )
2018
5
Effect of Adding Interferential Current in an Exercise and Manual Therapy Program for Patients With Unilateral Shoulder Impingement Syndrome: A Randomized Clinical Trial. ( 29459121 )
2018
6
Combined Use of Diadynamic Currents and Manual Therapy on Myofascial Trigger Points in Patients With Shoulder Impingement Syndrome: A Randomized Controlled Trial. ( 30098822 )
2018
7
Effects of kinesiology taping on shoulder girdle muscle activity and sports performance during badminton forehand overhead strokes in amateur badminton players with shoulder impingement syndrome. ( 30411603 )
2018
8
Comparison of Subacromial Ketorolac Injection versus Corticosteroid Injection in the Treatment of Shoulder Impingement Syndrome. ( 29417082 )
2017
9
Structured Wii protocol for rehabilitation of shoulder impingement syndrome: A pilot study. ( 28330586 )
2017
10
Stretching Exercises for Shoulder Impingement Syndrome: Effects of 6-week Program on Shoulder Tightness, Pain and Disability Status. ( 28095214 )
2017
11
Effectiveness of telerehabilitation programme following surgery in shoulder impingement syndrome (SIS): study protocol for a randomized controlled non-inferiority trial. ( 28231815 )
2017
12
Comparison of Anterior and Posterior Cortico-steroid Injections for Pain Relief and Functional Improvement in Shoulder Impingement Syndrome. ( 28856359 )
2017
13
Finnish Subacromial Impingement Arthroscopy Controlled Trial (FIMPACT): a protocol for a randomised trial comparing arthroscopic subacromial decompression and diagnostic arthroscopy (placebo control), with an exercise therapy control, in the treatment of shoulder impingement syndrome. ( 28588109 )
2017
14
Shoulder impingement syndrome: a systematic review of clinical trial participant selection criteria. ( 28572848 )
2017
15
Subacromial lipoma causing shoulder impingement syndrome. ( 28372305 )
2017
16
Short-Term Effects of Thoracic Spine Manipulation on Shoulder Impingement Syndrome: A Randomized Controlled Trial. ( 28259517 )
2017
17
Scapular asymmetry in participants with and without shoulder impingement syndrome; a three-dimensional motion analysis. ( 27614041 )
2016
18
Acromion Types and Role of Corticosteroid with Shoulder Impingement Syndrome. ( 28043311 )
2016
19
Physical Therapists' Perceptions and Use of Exercise in the Management of Subacromial Shoulder Impingement Syndrome: A Focus Group Study. ( 27013575 )
2016
20
Immediate Effects of Mobilization With Movement vs Sham Technique on Range of Motion, Strength, and Function in Patients With Shoulder Impingement Syndrome: Randomized Clinical Trial. ( 27829501 )
2016
21
Comparison of three types of exercise in the treatment of rotator cuff tendinopathy/shoulder impingement syndrome: A randomized controlled trial. ( 27884499 )
2016
22
Acupuncture treatment of shoulder impingement syndrome: A randomized controlled trial. ( 27062955 )
2016
23
Effectiveness of Kinesiotaping and Subacromial Corticosteroid Injection in Shoulder Impingement Syndrome. ( 27088466 )
2016
24
Effects of mobilization with movement on pain and range of motion in patients with unilateral shoulder impingement syndrome: a randomized controlled trial. ( 25936465 )
2015
25
Re: The addition of cervical unilateral posterior-anterior mobilisation in the treatment of patients with shoulder impingement syndrome: A randomized clinical trial. Cook C, Learman K, Houghton S, Showalter C, O'Halloran B. Man Ther 2014;19(1):18-24. ( 25680574 )
2015
26
High volume image guided injections and structured rehabilitation in shoulder impingement syndrome: a retrospective study. ( 26605194 )
2015
27
The reliability of rehabilitative ultrasound imaging in the measurement of infraspinatus muscle function in the symptomatic and asymptomatic shoulders of patients with unilateral shoulder impingement syndrome. ( 25883861 )
2015
28
The use of evidence-based practices for the management of shoulder impingement syndrome among Indian physical therapists: a cross-sectional survey. ( 26445417 )
2015
29
Treatments for Shoulder Impingement Syndrome: A PRISMA Systematic Review and Network Meta-Analysis. ( 25761173 )
2015
30
Response to Letter to the Editor: The addition of cervical Unilateral Posterior Anterior Mobilization (UPA) in the treatment of patients with shoulder impingement syndrome: A randomized clinical trial. ( 25744597 )
2015
31
The use of evidence-based practices for the management of shoulder impingement syndrome among Indian physical therapists: a cross-sectional survey. ( 26647749 )
2015
32
Management of the unilateral shoulder impingement syndrome. ( 25643310 )
2015
33
Predicting Response to Subacromial Injections and Lidocaine/Tetracaine Patch from Pretreatment Pain Quality in Patients with Shoulder Impingement Syndrome. ( 25917860 )
2015
34
Management of the unilateral shoulder impingement syndrome. ( 25643309 )
2015
35
Which patients do not recover from shoulder impingement syndrome, either with operative treatment or with nonoperative treatment? ( 25809315 )
2015
36
Glyceryl trinitrate patches-An alternative treatment for shoulder impingement syndrome. ( 30035035 )
2015
37
Neurocognitive therapeutic exercise improves pain and function in patients with shoulder impingement syndrome: a single-blind randomized controlled clinical trial. ( 24429918 )
2014
38
Closed Kinetic Chain Upper Extremity Stability test (CKCUES test): a reliability study in persons with and without shoulder impingement syndrome. ( 24387196 )
2014
39
Effects of conservative therapy applied before arthroscopic subacromial decompression on the clinical outcome in patients with stage 2 shoulder impingement syndrome. ( 25539560 )
2014
40
Optimal management of shoulder impingement syndrome. ( 24648778 )
2014
41
Rigid and Elastic taping changes scapular kinematics and pain in subjects with shoulder impingement syndrome; an experimental study. ( 25138646 )
2014
42
The addition of cervical unilateral posterior-anterior mobilisation in the treatment of patients with shoulder impingement syndrome: AA randomised clinical trial. ( 23791561 )
2014
43
Effectiveness of physiotherapy and costs in patients with clinical signs of shoulder impingement syndrome: One-year follow-up of a randomized controlled trial. ( 25211291 )
2014
44
The therapeutic role of motor imagery on the functional rehabilitation of a stage II shoulder impingement syndrome. ( 24575717 )
2014
45
Magnetic resonance imaging of rotator cuff tears in shoulder impingement syndrome. ( 25374626 )
2014
46
The Pain Quality Response Profile of a Corticosteroid Injections and Heated Lidocaine/Tetracaine Patch in the Treatment of Shoulder Impingement Syndrome. ( 25329142 )
2014
47
Does shoulder impingement syndrome affect the shoulder kinematics and associated muscle activity in archers? ( 25350034 )
2014
48
Summaries for patients: corticosteroid injections versus manual physical therapy for treatment of the shoulder impingement syndrome. ( 25089869 )
2014
49
Reliability and validity of the Norwegian version of the Disabilities of the Arm, Shoulder and Hand questionnaire in patients with shoulder impingement syndrome. ( 24618360 )
2014
50
Pragmatic study of corticosteroid injections and manual physical therapy for the shoulder impingement syndrome. ( 25089865 )
2014
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Variations for Shoulder Impingement Syndrome

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Expression for Shoulder Impingement Syndrome

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Search GEO for disease gene expression data for Shoulder Impingement Syndrome.
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Pathways for Shoulder Impingement Syndrome

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Pathways related to Shoulder Impingement Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling pathways regulating pluripotency of stem cells 37
11.4 SKIL ZFHX3
2
Immune response IFN gamma signaling pathway 22
Show member pathways
 10.81 LHB PDGFB SKIL
3
Transcriptional Regulatory Network in Embryonic Stem Cell 64
10.78 SKIL ZFHX3
4
Lung fibrosis 1
10.76 PDGFB SKIL
Sources

GO Terms for Shoulder Impingement Syndrome

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Cellular components related to Shoulder Impingement Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.62 LHB PDGFB

Biological processes related to Shoulder Impingement Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.33 JAG1 LHB PDGFB
2 hemopoiesis GO:0030097 8.96 JAG1 PDGFB
3 negative regulation of cell differentiation GO:0045596 8.62 JAG1 SKIL
Sources

Sources for Shoulder Impingement Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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