MCID: SHW001
MIFTS: 40

Shwartzman Phenomenon

Categories: Rare diseases, Blood diseases, Cardiovascular diseases

Aliases & Classifications for Shwartzman Phenomenon

MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 12 76 53 44 15 73
Shwartzman Reaction 12 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3825
MeSH 44 D012790
SNOMED-CT 68 24453002
UMLS 73 C0037018

Summaries for Shwartzman Phenomenon

MalaCards based summary : Shwartzman Phenomenon, also known as shwartzman reaction, is related to arthus reaction and disseminated intravascular coagulation. An important gene associated with Shwartzman Phenomenon is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. Affiliated tissues include skin, colon and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Shwartzman phenomenon, also known as Shwartzman reaction, is a rare reaction of a body to particular... more...

Related Diseases for Shwartzman Phenomenon

Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 arthus reaction 30.5 ICAM1 SELL
2 disseminated intravascular coagulation 30.2 F3 SERPINE1 THBD
3 meningococcemia 30.1 SERPINE1 THBD
4 systemic lupus erythematosus 28.7 F3 FCGR1A ICAM1 ITGAM SELE THBD
5 granulocytopenia 10.8 ITGAM SELL
6 cortical thymoma 10.7 ICAM1 VCAM1
7 heterophyiasis 10.6 ICAM1 SELE
8 cohen syndrome 10.6 ITGAM SELL
9 toxicodendron dermatitis 10.6 ICAM1 SELL
10 retinitis pigmentosa 60 10.6 SELE SELL
11 marantic endocarditis 10.6 F3 THBD
12 blue toe syndrome 10.6 F3 SERPINE1
13 immune-complex glomerulonephritis 10.6 ICAM1 VCAM1
14 tuberculous empyema 10.6 POMC SERPINE1
15 hymenolepiasis 10.6 ICAM1 SELE
16 catastrophic antiphospholipid syndrome 10.6 F3 SERPINE1
17 dysbaric osteonecrosis 10.6 F3 SERPINE1
18 carotid artery thrombosis 10.6 F3 SERPINE1
19 angina pectoris 10.6 F3 SERPINE1
20 cerebral falx meningioma 10.5 F3 KANTR
21 limbal stem cell deficiency 10.5 ICAM1 VCAM1
22 endophthalmitis 10.5 ICAM1 SELE
23 leech infestation 10.5 F3 KANTR
24 chronic active epstein-barr virus infection 10.5 SELE THBD
25 leukocyte adhesion deficiency, type i 10.5 ITGAM SELE SELL
26 thyroid crisis 10.5 KANTR POMC
27 laryngeal tuberculosis 10.5 KANTR POMC
28 anterior cranial fossa meningioma 10.5 F3 KANTR
29 mooren's ulcer 10.5 ICAM1 SELE VCAM1
30 glossopharyngeal neuralgia 10.4 KANTR POMC
31 dengue disease 10.4 FCGR1A ICAM1 VCAM1
32 actinic prurigo 10.4 ICAM1 SELE VCAM1
33 rheumatoid vasculitis 10.4 ICAM1 SELE VCAM1
34 takayasu arteritis 10.4 SELE THBD VCAM1
35 cytomegalovirus infection 10.4 ICAM1 SELE VCAM1
36 thrombotic thrombocytopenic purpura 10.4 F3 SELE THBD
37 autoinflammation, lipodystrophy, and dermatosis syndrome 10.4 ICAM1 SELE VCAM1
38 rhinitis 10.4 ICAM1 POMC VCAM1
39 antiphospholipid syndrome 10.4 F3 SELE THBD
40 hypersensitivity reaction type iii disease 10.4 ICAM1 SELE
41 buerger disease 10.4 SELE SERPINE1
42 synovitis 10.4 ICAM1 SELE VCAM1
43 boutonneuse fever 10.4 SELE SELL THBD
44 plummer's disease 10.3 ICAM1 SELE SELL
45 crescentic glomerulonephritis 10.3 ICAM1 SERPINE1 VCAM1
46 hepatic veno-occlusive disease 10.3 F3 SERPINE1 THBD
47 thrombophilia due to activated protein c resistance 10.3 F3 SERPINE1 THBD
48 lemierre's syndrome 10.3 F3 SERPINE1
49 thrombophilia due to thrombin defect 10.3 F3 SERPINE1 THBD
50 microvascular complications of diabetes 5 10.3 ICAM1 SERPINE1 VCAM1

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon

Symptoms & Phenotypes for Shwartzman Phenomenon

MGI Mouse Phenotypes related to Shwartzman Phenomenon:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ATRN SELE F3 SELL SERPINE1 ICAM1
2 hematopoietic system MP:0005397 10 SELE F3 SELL FCGR1A SERPINE1 ICAM1
3 cellular MP:0005384 9.97 SELE F3 SELL FCGR1A ICAM1 VCAM1
4 homeostasis/metabolism MP:0005376 9.93 ATRN SELE CD63 F3 SELL SERPINE1
5 immune system MP:0005387 9.7 SELE F3 SELL FCGR1A SERPINE1 ICAM1
6 integument MP:0010771 9.23 ATRN SELE F3 SELL SERPINE1 ICAM1

Drugs & Therapeutics for Shwartzman Phenomenon

Search Clinical Trials , NIH Clinical Center for Shwartzman Phenomenon

Cochrane evidence based reviews: shwartzman phenomenon

Genetic Tests for Shwartzman Phenomenon

Anatomical Context for Shwartzman Phenomenon

MalaCards organs/tissues related to Shwartzman Phenomenon:

41
Skin, Colon, Endothelial, Heart, Pituitary, Kidney, Lymph Node

Publications for Shwartzman Phenomenon

Articles related to Shwartzman Phenomenon:

(show top 50) (show all 108)
# Title Authors Year
1
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. ( 12043882 )
2002
2
Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. ( 7510492 )
1994
3
Aminoglycosides modify the in vitro metachromatic reaction and murine generalized Shwartzman phenomenon induced by Salmonella minnesota R595 lipopolysaccharide. ( 1759842 )
1991
4
Fournier's gangrene: the human counterpart of the local Shwartzman phenomenon? ( 2221955 )
1990
5
The effect of Shwartzman phenomenon on the pathogenesis of experimental acute pyelonephritis in rat. ( 3066072 )
1988
6
Function of phagocytes in experimentally induced colitis in rabbits. II. The Shwartzman phenomenon in the colon. ( 3721594 )
1986
7
Determination of the presence of root-bound endotoxin using the local Shwartzman phenomenon (LSP). ( 3882934 )
1985
8
Comparison of the capacity of two lipid A precursor molecules to express the local Shwartzman phenomenon. ( 3886545 )
1985
9
Effect of zinc on the local Shwartzman phenomenon. ( 6399184 )
1984
10
The Shwartzman phenomenon in equine species. ( 6759154 )
1982
11
Role of the acute phase response in the Shwartzman phenomenon. ( 7042139 )
1982
12
The effect of endotoxin on microcirculatory and lymphatic dynamics in the rat (Shwartzman phenomenon). ( 7285287 )
1981
13
Local Shwartzman phenomenon in athymic nude mice. ( 6154951 )
1980
14
Serological studies on the Shwartzman phenomenon-like reaction in germ free and conventional mice. ( 391306 )
1978
15
Experimental Shwartzman phenomenon in the heart muscle. ( 1098676 )
1975
16
The local Sanarelli-Shwartzman phenomenon in rats induced by human leukaemic cells. ( 4586905 )
1973
17
The generalized Shwartzman phenomenon in rabbits with denervated kidneys. ( 4989764 )
1970
18
Vasomotor factors in the Shwartzman phenomenon. ( 5361386 )
1969
19
Production of the Sanarelli-Shwartzman phenomenon by platelet-factor 3. ( 5375547 )
1969
20
The Shwartzman Phenomenon and acute hemorrhagic pancreatitis. A study in dogs. ( 4892955 )
1969
21
Intravascular coagulation, hyperlipemia, and fat embolism: their association during the generalized Shwartzman phenomenon in rabbits. ( 4892314 )
1969
22
Shwartzman phenomenon without endotoxin preparation. ( 4901847 )
1969
23
The effect of Phlogodym on the course of the Shwartzman phenomenon. II. Changes in lipid and glycoproteid metabolism. ( 5714671 )
1968
24
The effect of gold treatment on local Shwartzman phenomenon. ( 5729845 )
1968
25
Effect of hyperbaric oxygenation on the local Shwartzman phenomenon. ( 5657099 )
1968
26
The effect of Phlogodym on the course of the Shwartzman Phenomenon. I. Changes in blood fibrinogen level, thrombocyte count and in pathological picture. ( 5714670 )
1968
27
Immunologic specificity of the localized Shwartzman phenomenon induced in guinea pigs by simple chemical haptens. ( 4229796 )
1968
28
The effect of dimethyl sulfoxide on the local Shwartzman phenomenon. ( 5232240 )
1967
29
The effect of haemocoagulase (reptilase) on the local Shwartzman phenomenon. ( 5587524 )
1967
30
The effect of haemocoagulase (reptilase) on the local Shwartzman phenomenon. ( 4877865 )
1967
31
Heparin precipitable fraction (HPF) in hemorrhagic skin changes. I. HPF in the local Shwartzman phenomenon and hyperergic vascular reactions in rabbits. ( 4225172 )
1966
32
A re-appraisal of the role of blood coagulation and platelets in the generalized shwartzman phenomenon. ( 5989035 )
1966
33
Analysis of 21 septic abortion deaths with special reference to the Shwartzman phenomenon. ( 5950529 )
1966
34
Immunospecific endotoxin hypersensitivity in the induction of Shwartzman phenomenon. ( 4865149 )
1966
35
PLATELETS AND THE SHWARTZMAN PHENOMENON. ( 14264269 )
1965
36
EFFECTS OF EPINEPHRINE TOLERANCE ON THE SHWARTZMAN PHENOMENON. ( 14126664 )
1964
37
SHWARTZMAN PHENOMENON MECHANISM: NEWER CONCEPTS. INHIBITON BY ANTIBRADYKININ AND ANTISEROTONIN COMPOUNDS. ( 14184663 )
1964
38
EFFECT OF CYSTEINE ON LOCAL SHWARTZMAN PHENOMENON. ( 14181084 )
1964
39
SENSITIZATION BY STRESS FOR RENAL LESIONS RESEMBLING THOSE OF GENERALIZED SHWARTZMAN PHENOMENON. ( 14225400 )
1964
40
THE MECHANISM OF THE SANARELLI-SHWARTZMAN PHENOMENON IN HUMAN DISEASE. ( 14051170 )
1963
41
EFFECT OF ACETYLATED ENDOTOXIN OF DIMINISHED TOXICITY ON SHWARTZMAN PHENOMENON AND ON IMMUNOLOGICAL PHENOMENA ASSOCIATED WITH ENDOTOXINS. ( 14071445 )
1963
42
Shwartzman phenomenon in diabetic rabbits. ( 13979964 )
1963
43
The Shwartzman phenomenon in the colon of rabbits. The effects of epinephrine, norepinephrine, and mecholyl. ( 13941907 )
1963
44
A case of generalized Shwartzman phenomenon in the human. ( 14470812 )
1962
45
The Shwartzman phenomenon in the colon of rabbits. ( 13941908 )
1962
46
Purpura gangrenosa: report of a case, with a discussion of the Shwartzman phenomenon. ( 13899133 )
1962
47
Effect of temperature on the localized Shwartzman phenomenon. ( 13688878 )
1961
48
Effect of trypsin inhibitors on Shwartzman phenomenon. ( 13879345 )
1961
49
Local endotoxin hypersensitivity and its relation to the Shwartzman phenomenon. ( 13753682 )
1961
50
Inhibition of the local Shwartzman phenomenon by the administration of epsilon amino caproic acid. ( 13739376 )
1961

Variations for Shwartzman Phenomenon

Expression for Shwartzman Phenomenon

Search GEO for disease gene expression data for Shwartzman Phenomenon.

Pathways for Shwartzman Phenomenon

Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 CD63 CEACAM8 F3 ITGAM SELE SELL
2
Show member pathways
12.61 CEACAM8 ICAM1 ITGAM SERPINE1 VCAM1
3
Show member pathways
12 F3 KLK1 SERPINE1 THBD
4
Show member pathways
11.96 ICAM1 ITGAM VCAM1
5 11.92 F3 ITGAM SERPINE1 THBD
6
Show member pathways
11.91 CEACAM8 ITGAM SELE SELL THBD
7 11.9 ICAM1 SELE THBD VCAM1
8 11.85 CEACAM8 ITGAM SELL
9 11.84 FCGR1A ICAM1 SELL VCAM1
10 11.8 ICAM1 SELE VCAM1
11 11.73 ICAM1 ITGAM POMC VCAM1
12 11.71 ICAM1 ITGAM SELE SELL VCAM1
13 11.67 ICAM1 POMC SELE
14 11.62 ITGAM SELL THBD
15
Show member pathways
11.54 ICAM1 SELE VCAM1
16 11.47 FCGR1A ICAM1 ITGAM
17 11.44 CD63 F3 ICAM1 SERPINE1 VCAM1
18 11.4 ICAM1 SELE VCAM1
19 11.35 ICAM1 SELE VCAM1
20 11.33 ICAM1 ITGAM VCAM1
21 11.15 ICAM1 SELE VCAM1
22 11.1 F3 ICAM1 SELE SERPINE1 THBD VCAM1
23 10.8 ICAM1 VCAM1

GO Terms for Shwartzman Phenomenon

Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 ATRN CD63 CEACAM8 ICAM1 SELE SELL
2 extracellular exosome GO:0070062 9.85 APCS ATRN CD63 CEACAM8 F3 ICAM1
3 external side of plasma membrane GO:0009897 9.71 ICAM1 ITGAM SELL VCAM1
4 extracellular matrix GO:0031012 9.62 APCS F3 ICAM1 SERPINE1
5 cell surface GO:0009986 9.5 CD63 F3 ICAM1 ITGAM SELL THBD
6 extracellular space GO:0005615 9.4 APCS ATRN CD63 CEACAM8 F3 ICAM1
7 integral component of membrane GO:0016021 10.17 ATRN CD63 F3 FCGR1A ICAM1 ITGAM
8 plasma membrane GO:0005886 10.03 ATRN CD63 CEACAM8 F3 FCGR1A ICAM1

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.8 CD63 ICAM1 ITGAM SELE SELL VCAM1
2 regulation of immune response GO:0050776 9.78 FCGR1A ICAM1 SELL VCAM1
3 extracellular matrix organization GO:0030198 9.76 ICAM1 ITGAM SERPINE1 VCAM1
4 response to lipopolysaccharide GO:0032496 9.73 ICAM1 SELE THBD VCAM1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.67 FCGR1A ICAM1 VCAM1
6 cytokine-mediated signaling pathway GO:0019221 9.65 F3 ICAM1 ITGAM POMC VCAM1
7 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 ICAM1 SELE VCAM1
8 positive regulation of receptor internalization GO:0002092 9.56 CD63 SELE
9 acute inflammatory response GO:0002526 9.55 KLK1 VCAM1
10 negative regulation of blood coagulation GO:0030195 9.54 SERPINE1 THBD
11 negative regulation of wound healing GO:0061045 9.52 APCS SERPINE1
12 negative regulation of fibrinolysis GO:0051918 9.51 SERPINE1 THBD
13 membrane to membrane docking GO:0022614 9.37 ICAM1 VCAM1
14 leukocyte cell-cell adhesion GO:0007159 9.33 ICAM1 SELE VCAM1
15 leukocyte tethering or rolling GO:0050901 9.13 SELE SELL VCAM1
16 leukocyte migration GO:0050900 9.1 CEACAM8 ICAM1 ITGAM SELE SELL THBD

Molecular functions related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 F3 SELL SERPINE1
2 oligosaccharide binding GO:0070492 8.96 SELE SELL
3 carbohydrate binding GO:0030246 8.92 APCS ATRN SELE SELL

Sources for Shwartzman Phenomenon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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