MCID: SHW001
MIFTS: 38

Shwartzman Phenomenon

Categories: Blood diseases, Cardiovascular diseases, Rare diseases
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Aliases & Classifications for Shwartzman Phenomenon

MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 11 19 75 43 14 71
Shwartzman Reaction 11 53

Classifications:



External Ids:

Disease Ontology 11 DOID:3825
MeSH 43 D012790
SNOMED-CT 68 24453002
UMLS 71 C0037018

Summaries for Shwartzman Phenomenon

GARD: 19 Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.

MalaCards based summary: Shwartzman Phenomenon, also known as shwartzman reaction, is related to toxic shock syndrome and arthus reaction. An important gene associated with Shwartzman Phenomenon is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Cytokine Signaling in Immune system and ECM proteoglycans. Affiliated tissues include skin, endothelial and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia: 75 Shwartzman phenomenon is a rare reaction of a body to particular types of toxins, called endotoxins,... more...

Related Diseases for Shwartzman Phenomenon

Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 30.4 TNF TLR4 F3
2 arthus reaction 30.3 TNF ICAM1
3 salmonellosis 30.1 TNF TLR4 ITGAM
4 adult respiratory distress syndrome 30.0 TNF SELE ITGAM
5 allergic disease 30.0 VCAM1 TNF SELE ICAM1
6 acute pyelonephritis 30.0 TNF TLR4
7 meningitis 29.9 TNF TLR4 ICAM1
8 vasculitis 29.8 VCAM1 TNF SELE ITGAM ICAM1
9 amebiasis 29.7 TNF TLR4 ICAM1
10 bacterial sepsis 29.7 TNF TLR4 ITGAM F3
11 acute pancreatitis 29.6 TNF TLR4 ICAM1
12 thrombosis 29.4 VCAM1 SERPINA10 SELE F3 F12
13 respiratory failure 29.4 TNF TLR4 ICAM1 F3
14 combined immunodeficiency 29.1 TNF SELE ITGAM IL2RB ICAM1
15 thrombocytopenia 29.0 TNF TLR4 SELE ITGAM ICAM1 F3
16 vascular disease 29.0 VCAM1 TNF SELE ITGAM ICAM1 F3
17 myocardial infarction 28.6 VCAM1 TNF TLR4 SELE ITGAM ICAM1
18 pre-eclampsia 28.6 VCAM1 TNF TLR4 SELE ITGAM ICAM1
19 systemic lupus erythematosus 28.5 VCAM1 TNF TLR4 SELE ITGAM IL2RB
20 disseminated intravascular coagulation 10.4
21 typhoid fever 10.3
22 purpura 10.3
23 high molecular weight kininogen deficiency 10.2 F3 F12
24 angioedema, hereditary, 3 10.2 F3 F12
25 diphtheria 10.2
26 pericoronitis 10.2 TNF F3
27 aspiration pneumonitis 10.2 TNF F3
28 hemolytic uremic syndrome, atypical 1 10.2
29 hemolytic-uremic syndrome 10.2
30 cauda equina syndrome 10.2 TNF F3
31 heart aneurysm 10.2 TNF F3
32 coronary aneurysm 10.2 TNF F3
33 ischemic colitis 10.2 TNF F3
34 non-severe covid-19 10.2 TNF F3
35 silo filler's disease 10.1 TLR4 ITGAM
36 hemorrhoid 10.1 TNF F3
37 compartment syndrome 10.1 TNF F3
38 necrotizing fasciitis 10.1 TNF F3
39 systemic lupus erythematosus 1 10.1
40 ascaris lumbricoides infection 10.1
41 dermatitis 10.1
42 neurotic disorder 10.1
43 herpes zoster 10.1
44 lupus erythematosus 10.1
45 pemphigus 10.1
46 pouchitis 10.1 TNF TLR4
47 macular degeneration, age-related, 9 10.1 VCAM1 ICAM1
48 metal allergy 10.1 TNF TLR4
49 oral lichen planus 10.1 VCAM1 ICAM1
50 inflammatory and toxic neuropathy 10.1 TNF SELE

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon

Symptoms & Phenotypes for Shwartzman Phenomenon

MGI Mouse Phenotypes related to Shwartzman Phenomenon:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 F12 F3 ICAM1 ITGAM SELE SERPINA10
2 cardiovascular system MP:0005385 9.86 F3 ICAM1 SELE SERPINA10 TLR4 TNF
3 immune system MP:0005387 9.81 F3 ICAM1 IL2RB ITGAM SELE TLR4
4 hematopoietic system MP:0005397 9.61 F3 ICAM1 IL2RB ITGAM SELE TLR4
5 integument MP:0010771 9.17 F3 ICAM1 IL2RB SELE TLR4 TNF

Drugs & Therapeutics for Shwartzman Phenomenon

Search Clinical Trials, NIH Clinical Center for Shwartzman Phenomenon

Cochrane evidence based reviews: shwartzman phenomenon

Genetic Tests for Shwartzman Phenomenon

Anatomical Context for Shwartzman Phenomenon

Organs/tissues related to Shwartzman Phenomenon:

MalaCards : Skin, Endothelial, Liver, Kidney, Neutrophil, T Cells, Colon

Publications for Shwartzman Phenomenon

Articles related to Shwartzman Phenomenon:

(show top 50) (show all 783)
# Title Authors PMID Year
1
Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. 53 62
18424751 2008
2
Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. 53 62
12488365 2003
3
A cross-linked anti-TNF-α aptamer for neutralization of TNF-α-induced cutaneous Shwartzman phenomenon: A simple and novel approach for improving aptamers' affinity and efficiency. 62
34218531 2021
4
Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction. 62
31269748 2019
5
Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head. 62
31258650 2019
6
Whatever happened to the Shwartzman phenomenon? 62
30409091 2018
7
A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides. 62
29902933 2018
8
Brief Report: Endothelial-Specific X-Box Binding Protein 1 Deficiency Limits Tumor Necrosis Factor-Induced Leukocyte Recruitment and Vasculitis. 62
26245636 2015
9
Renal failure due to Capnocytophaga canimorsus generalized Shwartzman reaction from a dog bite (DF-2 nephropathy). 62
24688203 2014
10
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. 62
23963134 2013
11
The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents. 62
23407995 2013
12
A plausible explanation for male dominance in typhoid ileal perforation. 62
23180972 2012
13
The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat and high-cholesterol diet. 62
21937954 2011
14
How inflammation modulates central nervous system vessel activation and provides targets for intervention--a personal perspective. 62
20955418 2010
15
Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. 62
20559805 2010
16
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. 62
19696743 2009
17
Novel mechanism of C-reactive protein for enhancing mouse liver innate immunity. 62
19444871 2009
18
IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice. 62
18653461 2008
19
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. 62
17641206 2007
20
Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation. 62
17600275 2007
21
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. 62
17560833 2007
22
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. 62
17372019 2007
23
The Shwartzman reaction repealed: an interview with Dr. Guido Sireci by Helene F. Rosenberg. 62
17200143 2007
24
Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. 62
17380303 2007
25
Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock. 62
17046969 2007
26
The Shwartzman reaction repealed. 62
29350849 2007
27
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. 62
16930474 2006
28
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. 62
16864696 2006
29
An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. 62
16387840 2006
30
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. 62
15809354 2005
31
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice. 62
15627978 2005
32
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. 62
15489643 2004
33
Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. 62
15528377 2004
34
Mast cell density during initiation and progression of the local Shwartzman reaction. 62
15021965 2004
35
Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. 62
14557414 2003
36
Disseminated intravascular coagulation. 62
14502252 2003
37
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. 62
12043882 2002
38
Mouse soluble CD14 truncated at amino acid 71 in transgenic mice: preventive effect on endotoxin-mediated toxic shock. 62
12476036 2002
39
Different pathways leading to cutaneous leukocytoclastic vasculitis in mice. 62
11737258 2001
40
Synthesis and immunological activity of water-soluble thalidomide prodrugs. 62
11377186 2001
41
Depletion of plasma factor XIII prevents disseminated intravascular coagulation-induced organ damage. 62
11307816 2001
42
Towards a 'human-like' model of tuberculosis: intranasal inoculation of LPS induces intragranulomatous lung necrosis in mice infected aerogenically with Mycobacterium tuberculosis. 62
11169208 2001
43
The fibrin intermediate, its place in the fibrinogen-fibrin transformation. 62
11460472 2001
44
Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. 62
11104806 2000
45
Pro-coagulant state resulting from high levels of soluble P-selectin in blood. 62
11095738 2000
46
The rôle of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis. Long-term clinical and microbiological observations. 62
10959784 2000
47
In vivo natural killer cell activities revealed by natural killer cell-deficient mice. 62
10694580 2000
48
Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. 62
10657604 2000
49
Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody. 62
10789508 2000
50
alpha-MSH reduces vasculitis in the local Shwartzman reaction. 62
10816677 1999

Variations for Shwartzman Phenomenon

Expression for Shwartzman Phenomenon

Search GEO for disease gene expression data for Shwartzman Phenomenon.

Pathways for Shwartzman Phenomenon

Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 VCAM1 TNF ITGAM IL2RB ICAM1
2
Show member pathways
11.98 VCAM1 ITGAM ICAM1
3 11.87 VCAM1 TREML1 ICAM1
4 11.82 VCAM1 ICAM1 F3
5 11.79 TNF ITGAM IL2RB
6 11.77 TNF TLR4 ICAM1
7 11.7 VCAM1 TNF ITGAM ICAM1
8 11.6 TNF ITGAM IL2RB
9 11.56 TNF TLR4 ICAM1
10
Show member pathways
11.36 VCAM1 TNF SELE ICAM1
11 11.31 VCAM1 ITGAM ICAM1
12 11.29 ITGAM TLR4 TNF
13 11.25 VCAM1 TNF TLR4 ICAM1
14 11.16 VCAM1 SELE ICAM1
15 11.09 VCAM1 ICAM1
16 11.07 VCAM1 ITGAM ICAM1
17 11.04 TNF ITGAM ICAM1
18 10.97 VCAM1 TNF SELE ICAM1
19 10.85 VCAM1 TNF
20 10.7 VCAM1 TNF ICAM1
21 10.61 TNF TLR4 ITGAM F12

GO Terms for Shwartzman Phenomenon

Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.34 F3 ICAM1 IL2RB ITGAM LILRA6 SELE
2 membrane GO:0016021 10.34 F3 ICAM1 IL2RB ITGAM LILRA6 SELE
3 extracellular space GO:0005615 10.22 VCAM1 TNF SERPINA10 SELE ITGAM ICAM1
4 plasma membrane GO:0005887 10.18 F3 ICAM1 IL2RB SELE TLR4 TNF
5 plasma membrane GO:0005886 10.18 F3 ICAM1 IL2RB SELE TLR4 TNF
6 membrane raft GO:0045121 9.91 TNF SELE ITGAM ICAM1
7 cell surface GO:0009986 9.86 F3 ICAM1 IL2RB ITGAM TLR4 TNF
8 external side of plasma membrane GO:0009897 9.5 VCAM1 TNF TLR4 SELE ITGAM IL2RB

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.99 SERPINA10 F3 F12
2 positive regulation of interleukin-8 production GO:0032757 9.95 TNF TLR4 F3
3 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.91 VCAM1 SELE ICAM1
4 response to lipopolysaccharide GO:0032496 9.91 VCAM1 TNF TLR4 SELE
5 regulation of inflammatory response GO:0050727 9.84 TNF TLR4 SELE
6 leukocyte migration involved in inflammatory response GO:0002523 9.83 TNF SELE
7 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.8 TNF TLR4
8 positive regulation of oxidative stress-induced neuron death GO:1903223 9.76 TNF TLR4
9 leukocyte cell-cell adhesion GO:0007159 9.73 VCAM1 SELE ICAM1
10 membrane to membrane docking GO:0022614 9.71 ICAM1 VCAM1
11 hemostasis GO:0007599 9.5 SERPINA10 F3 F12
12 leukocyte migration GO:0050900 9.46 TNF SELE ICAM1
13 leukocyte tethering or rolling GO:0050901 9.43 VCAM1 TNF SELE
14 cellular response to amyloid-beta GO:1904646 9.23 VCAM1 TNF TLR4 ICAM1

Molecular functions related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.23 TREML1 TLR4 SELE ICAM1

Sources for Shwartzman Phenomenon

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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