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MCID: SHW001
MIFTS: 36

Shwartzman Phenomenon

Categories: Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Shwartzman Phenomenon

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MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 12 73 20 44 15 70
Shwartzman Reaction 12 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3825
MeSH 44 D012790
SNOMED-CT 67 24453002
UMLS 70 C0037018
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Summaries for Shwartzman Phenomenon

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MalaCards based summary : Shwartzman Phenomenon, also known as shwartzman reaction, is related to granulocytopenia and arthus reaction. An important gene associated with Shwartzman Phenomenon is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, kidney and endothelial, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Shwartzman phenomenon is a rare reaction of a body to particular types of toxins, called endotoxins,... more...

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Related Diseases for Shwartzman Phenomenon

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Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 granulocytopenia 30.3 TNF ITGAM
2 arthus reaction 30.0 TNF ICAM1
3 bacterial sepsis 29.9 VCAM1 TNF SELE
4 adult respiratory distress syndrome 29.8 TNF SELE ITGAM
5 amebiasis 29.8 TNF ICAM1
6 vasculitis 29.3 VCAM1 TNF SELE ITGAM ICAM1
7 thrombocytopenia 29.2 TNF SELE ITGAM ICAM1 F3
8 combined immunodeficiency 29.2 TNF SELE ITGAM IL2RB ICAM1
9 vascular disease 29.0 VCAM1 TNF SELE ITGAM ICAM1 F3
10 pre-eclampsia 29.0 VCAM1 TNF SELE ITGAM ICAM1 F3
11 systemic lupus erythematosus 28.9 VCAM1 TNF SELE ITGAM IL2RB ICAM1
12 toxic shock syndrome 10.3
13 typhoid fever 10.3
14 allergic disease 10.3
15 purpura 10.3
16 high molecular weight kininogen deficiency 10.2 F3 F12
17 aspiration pneumonitis 10.2 TNF F3
18 disseminated intravascular coagulation 10.2
19 diphtheria 10.2
20 macular degeneration, age-related, 9 10.2 VCAM1 ICAM1
21 hantavirus hemorrhagic fever with renal syndrome 10.2 TNF F3
22 hemolytic-uremic syndrome 10.2
23 autoimmune disease of eyes, ear, nose and throat 10.2 TNF ITGAM
24 mooren's ulcer 10.2 VCAM1 ICAM1
25 compartment syndrome 10.2 TNF F3
26 limbal stem cell deficiency 10.2 VCAM1 ICAM1
27 buerger disease 10.2 VCAM1 ICAM1
28 cecal disease 10.2 TNF F3
29 oligoarticular juvenile idiopathic arthritis 10.2 TNF IL2RB
30 drug-induced lupus erythematosus 10.1 TNF ITGAM
31 inflammatory and toxic neuropathy 10.1 TNF SELE
32 acute hemorrhagic encephalitis 10.1 ICAM1 F3
33 bronchopneumonia 10.1 TNF F3
34 acute graft versus host disease 10.1 TNF IL2RB
35 neurotic disorder 10.1
36 herpes zoster 10.1
37 lupus erythematosus 10.1
38 pemphigus 10.1
39 meningitis 10.1
40 aspiration pneumonia 10.1 TNF ITGAM F3
41 parametritis 10.1 ICAM1 F3
42 pustulosis palmaris et plantaris 10.1 TNF SELE
43 background diabetic retinopathy 10.1 TNF ICAM1
44 clostridium difficile colitis 10.1
45 salmonellosis 10.1
46 severe combined immunodeficiency 10.1
47 african tick-bite fever 10.1 TNF SELE
48 x-linked recessive disease 10.1 TNF ITGAM F3
49 monocytic leukemia 10.1 TNF ITGAM F3
50 funisitis 10.1 TNF SELE

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon
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Symptoms & Phenotypes for Shwartzman Phenomenon

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MGI Mouse Phenotypes related to Shwartzman Phenomenon:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 DUSP10 F3 ICAM1 IL2RB ITGAM SELE
2 immune system MP:0005387 9.28 DUSP10 F3 ICAM1 IL2RB ITGAM SELE
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Drugs & Therapeutics for Shwartzman Phenomenon

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Search Clinical Trials , NIH Clinical Center for Shwartzman Phenomenon

Cochrane evidence based reviews: shwartzman phenomenon

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Genetic Tests for Shwartzman Phenomenon

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Anatomical Context for Shwartzman Phenomenon

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MalaCards organs/tissues related to Shwartzman Phenomenon:

40
Skin, Kidney, Endothelial, Neutrophil, Colon, T Cells, Liver
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Publications for Shwartzman Phenomenon

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Articles related to Shwartzman Phenomenon:

(show top 50) (show all 782)
# Title Authors PMID Year
1
Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. 54 61
18424751 2008
2
Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. 54 61
12488365 2003
3
Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction. 61
31269748 2019
4
Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head. 61
31258650 2019
5
Whatever happened to the Shwartzman phenomenon? 61
30409091 2018
6
A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides. 61
29902933 2018
7
Brief Report: Endothelial-Specific X-Box Binding Protein 1 Deficiency Limits Tumor Necrosis Factor-Induced Leukocyte Recruitment and Vasculitis. 61
26245636 2015
8
Renal failure due to Capnocytophaga canimorsus generalized Shwartzman reaction from a dog bite (DF-2 nephropathy). 61
24688203 2014
9
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. 61
23963134 2013
10
The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents. 61
23407995 2013
11
A plausible explanation for male dominance in typhoid ileal perforation. 61
23180972 2012
12
The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat and high-cholesterol diet. 61
21937954 2011
13
How inflammation modulates central nervous system vessel activation and provides targets for intervention--a personal perspective. 61
20955418 2010
14
Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. 61
20559805 2010
15
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. 61
19696743 2009
16
Novel mechanism of C-reactive protein for enhancing mouse liver innate immunity. 61
19444871 2009
17
IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice. 61
18653461 2008
18
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. 61
17641206 2007
19
Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation. 61
17600275 2007
20
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. 61
17560833 2007
21
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. 61
17372019 2007
22
Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock. 61
17046969 2007
23
Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. 61
17380303 2007
24
The Shwartzman reaction repealed: an interview with Dr. Guido Sireci by Helene F. Rosenberg. 61
17200143 2007
25
The Shwartzman reaction repealed. 61
29350849 2007
26
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. 61
16930474 2006
27
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. 61
16864696 2006
28
An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. 61
16387840 2006
29
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. 61
15809354 2005
30
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice. 61
15627978 2005
31
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. 61
15489643 2004
32
Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. 61
15528377 2004
33
Mast cell density during initiation and progression of the local Shwartzman reaction. 61
15021965 2004
34
Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. 61
14557414 2003
35
Disseminated intravascular coagulation. 61
14502252 2003
36
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. 61
12043882 2002
37
Mouse soluble CD14 truncated at amino acid 71 in transgenic mice: preventive effect on endotoxin-mediated toxic shock. 61
12476036 2002
38
Different pathways leading to cutaneous leukocytoclastic vasculitis in mice. 61
11737258 2001
39
Synthesis and immunological activity of water-soluble thalidomide prodrugs. 61
11377186 2001
40
Depletion of plasma factor XIII prevents disseminated intravascular coagulation-induced organ damage. 61
11307816 2001
41
Towards a 'human-like' model of tuberculosis: intranasal inoculation of LPS induces intragranulomatous lung necrosis in mice infected aerogenically with Mycobacterium tuberculosis. 61
11169208 2001
42
The fibrin intermediate, its place in the fibrinogen-fibrin transformation. 61
11460472 2001
43
Pro-coagulant state resulting from high levels of soluble P-selectin in blood. 61
11095738 2000
44
Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. 61
11104806 2000
45
The rôle of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis. Long-term clinical and microbiological observations. 61
10959784 2000
46
In vivo natural killer cell activities revealed by natural killer cell-deficient mice. 61
10694580 2000
47
Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. 61
10657604 2000
48
Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody. 61
10789508 2000
49
alpha-MSH reduces vasculitis in the local Shwartzman reaction. 61
10816677 1999
50
Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized shwartzman reaction and its relationship to apoptosis. 61
10417181 1999
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Variations for Shwartzman Phenomenon

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Expression for Shwartzman Phenomenon

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Search GEO for disease gene expression data for Shwartzman Phenomenon.
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Pathways for Shwartzman Phenomenon

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Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.82 VCAM1 TREML1 TNF LILRA6 ITGAM IL2RB
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.15 VCAM1 TNF ITGAM IL2RB ICAM1 DUSP10
3
RANK Signaling in Osteoclasts 63
Show member pathways
 12.48 VCAM1 TNF LILRA6 ICAM1
4
ECM-receptor interaction 36
Show member pathways
 11.98 VCAM1 ITGAM ICAM1
5
Cell adhesion molecules 36
11.95 VCAM1 SELE ITGAM ICAM1
6
Complement and coagulation cascades 36 1
11.94 ITGAM F3 F12
7
Fluid shear stress and atherosclerosis 36
11.9 VCAM1 TNF SELE ICAM1
8
Adhesion 4
11.86 VCAM1 ICAM1 F3
9
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.86 VCAM1 TREML1 LILRA6 ICAM1
10
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.82 TNF ITGAM IL2RB
11
NF-kappa B signaling pathway 36
11.77 VCAM1 TNF ICAM1
12
Interleukin-4 and 13 signaling 65
11.76 VCAM1 TNF ITGAM ICAM1
13
TNF signaling pathway 36
11.72 VCAM1 TNF SELE ICAM1
14
Innate Lymphoid Cell Differentiation Pathways 64
11.64 TNF ITGAM IL2RB
15
IgA-Producing B Cells in the Intestine 64
11.54 VCAM1 TNF ICAM1
16
MSP-RON Signaling 63
11.39 TNF ITGAM F12
17
amb2 Integrin signaling 1
11.38 TNF ITGAM ICAM1
18
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.36 VCAM1 TNF SELE ICAM1
19
Thromboxane A2 receptor signaling 1
11.34 VCAM1 SELE ICAM1
20
Immune response_Role of integrins in NK cells cytotoxicity 23
11.31 VCAM1 ITGAM ICAM1
21
Malaria 36
11.16 VCAM1 TNF SELE ICAM1
22
AGE-RAGE signaling pathway in diabetic complications 36
11.02 VCAM1 TNF SELE ICAM1 F3
23
Cellular roles of Anthrax toxin 1
10.96 VCAM1 TNF
24
African trypanosomiasis 36
10.82 VCAM1 TNF SELE ICAM1
25
LDL Oxidation in Atherogenesis 63
10.7 VCAM1 TNF ICAM1
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GO Terms for Shwartzman Phenomenon

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Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 VCAM1 TREML1 TNF SELE ITGAM IL2RB
2 membrane raft GO:0045121 9.56 TNF SELE ITGAM ICAM1
3 extracellular space GO:0005615 9.56 VCAM1 TNF SERPINA10 SELE ITGAM ICAM1
4 external side of plasma membrane GO:0009897 9.55 VCAM1 TNF ITGAM IL2RB ICAM1
5 cell surface GO:0009986 9.17 VCAM1 TREML1 TNF ITGAM IL2RB ICAM1

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.76 VCAM1 TNF ITGAM ICAM1
2 blood coagulation GO:0007596 9.69 SERPINA10 F3 F12
3 leukocyte migration GO:0050900 9.67 TNF SELE ITGAM ICAM1
4 hemostasis GO:0007599 9.58 SERPINA10 F3 F12
5 response to lipopolysaccharide GO:0032496 9.56 VCAM1 SELE ICAM1 DUSP10
6 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.5 VCAM1 SELE ICAM1
7 microglial cell activation GO:0001774 9.49 TNF ITGAM
8 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.48 TNF ICAM1
9 membrane to membrane docking GO:0022614 9.43 VCAM1 ICAM1
10 leukocyte cell-cell adhesion GO:0007159 9.33 VCAM1 SELE ICAM1
11 leukocyte tethering or rolling GO:0050901 9.13 VCAM1 TNF SELE
12 cytokine-mediated signaling pathway GO:0019221 9.1 VCAM1 TNF ITGAM IL2RB ICAM1 F3

Molecular functions related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 VCAM1 ITGAM ICAM1
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Sources for Shwartzman Phenomenon

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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