MCID: SHW001
MIFTS: 37

Shwartzman Phenomenon

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Shwartzman Phenomenon

MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 12 77 54 45 15 74
Shwartzman Reaction 12 56

Classifications:



External Ids:

Disease Ontology 12 DOID:3825
MeSH 45 D012790
SNOMED-CT 69 24453002
UMLS 74 C0037018

Summaries for Shwartzman Phenomenon

MalaCards based summary : Shwartzman Phenomenon, also known as shwartzman reaction, is related to purpura and granulocytopenia. An important gene associated with Shwartzman Phenomenon is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Affiliated tissues include kidney, skin and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Shwartzman phenomenon is a rare reaction of a body to particular types of toxins, called endotoxins,... more...

Related Diseases for Shwartzman Phenomenon

Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 purpura 30.2 F3 TNF
2 granulocytopenia 30.1 ITGAM TNF
3 pyoderma 30.0 F3 TNF
4 systemic lupus erythematosus 29.6 F3 ITGAM TNF VCAM1
5 lymphocytic vasculitis 10.3 ITGAM VCAM1
6 chronic venous insufficiency 10.2 ITGAM VCAM1
7 grange syndrome 10.2 F3 VCAM1
8 pulmonary immaturity 10.2 F3 VCAM1
9 factor xii deficiency 10.2 F12 F3
10 factor xi deficiency 10.2 F12 F3
11 lupus erythematosus 10.1
12 penicilliosis 10.1 ITGAM TNF
13 actinic prurigo 10.1 TNF VCAM1
14 rheumatoid vasculitis 10.1 TNF VCAM1
15 hepatitis 10.1
16 salmonellosis 10.1
17 thrombosis 10.1
18 dermatitis 10.1
19 vasculitis 10.1
20 heparin-induced thrombocytopenia 10.1
21 antiphospholipid syndrome 10.1 F3 VCAM1
22 localized scleroderma 10.1 TNF VCAM1
23 peripheral vascular disease 10.1 F3 VCAM1
24 viral encephalitis 10.1 TNF VCAM1
25 crimean-congo hemorrhagic fever 10.0 F3 TNF
26 rheumatic heart disease 10.0 TNF VCAM1
27 scrub typhus 10.0 F3 TNF
28 primary progressive multiple sclerosis 10.0 TNF VCAM1
29 endocarditis 10.0 TNF VCAM1
30 takayasu arteritis 10.0 TNF VCAM1
31 intracranial hypertension 10.0 F3 TNF
32 sickle cell anemia 10.0 TNF VCAM1
33 neutropenia 10.0
34 colitis 10.0
35 purpura fulminans 10.0
36 disseminated intravascular coagulation 10.0
37 pyelonephritis 10.0
38 eclampsia 10.0
39 arthus reaction 10.0
40 kidney cortex necrosis 10.0
41 pancreatitis 10.0
42 acute pyelonephritis 10.0
43 pyoderma gangrenosum 10.0
44 meningitis 10.0
45 fournier gangrene 10.0
46 meningococcemia 10.0
47 lymphangiosarcoma 10.0 ESAM TNF
48 dengue hemorrhagic fever 10.0 F3 TNF
49 peritonitis 9.9 ITGAM TNF
50 budd-chiari syndrome 9.9

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon

Symptoms & Phenotypes for Shwartzman Phenomenon

MGI Mouse Phenotypes related to Shwartzman Phenomenon:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ESAM F3 PRDM6 SERPINA10 TNF VCAM1
2 homeostasis/metabolism MP:0005376 9.17 F12 F3 ITGAM PRDM6 SERPINA10 TNF

Drugs & Therapeutics for Shwartzman Phenomenon

Search Clinical Trials , NIH Clinical Center for Shwartzman Phenomenon

Cochrane evidence based reviews: shwartzman phenomenon

Genetic Tests for Shwartzman Phenomenon

Anatomical Context for Shwartzman Phenomenon

MalaCards organs/tissues related to Shwartzman Phenomenon:

42
Kidney, Skin, Heart, Liver, Endothelial, Brain, Colon

Publications for Shwartzman Phenomenon

Articles related to Shwartzman Phenomenon:

(show top 50) (show all 368)
# Title Authors Year
1
Whatever happened to the Shwartzman phenomenon? ( 30409091 )
2018
2
Renal failure due to Capnocytophaga canimorsus generalized Shwartzman reaction from a dog bite (DF-2 nephropathy). ( 24688203 )
2014
3
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. ( 23963134 )
2013
4
The Shwartzman reaction repealed: an interview with Dr. Guido Sireci by Helene F. Rosenberg. ( 17200143 )
2007
5
Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. ( 17380303 )
2007
6
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. ( 17560833 )
2007
7
The Shwartzman reaction repealed. ( 29350849 )
2007
8
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. ( 16864696 )
2006
9
An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. ( 16387840 )
2006
10
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. ( 16930474 )
2006
11
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice. ( 15627978 )
2005
12
Mast cell density during initiation and progression of the local Shwartzman reaction. ( 15021965 )
2004
13
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. ( 15489643 )
2004
14
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. ( 12043882 )
2002
15
Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. ( 10657604 )
2000
16
Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody. ( 10789508 )
2000
17
Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. ( 11104806 )
2000
18
Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized shwartzman reaction and its relationship to apoptosis. ( 10417181 )
1999
19
alpha-MSH reduces vasculitis in the local Shwartzman reaction. ( 10816677 )
1999
20
Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction. ( 9531314 )
1998
21
Expression of intercellular adhesion molecule-1 (ICAM-1) on vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction as an experimental disseminated intravascular coagulation model. ( 9215589 )
1997
22
Involvement of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-8, and interleukin-1 receptor antagonist in acute lung injury caused by local Shwartzman reaction. ( 9051688 )
1997
23
Early graft loss secondary to massive hemorrhagic necrosis following orthotopic liver transplantation. Evidence for cytokine-mediated univisceral Shwartzman reaction. ( 8629299 )
1996
24
Immunomodulation of LPS ability to induce the local Shwartzman reaction. ( 8972735 )
1996
25
Apoptotic cell death of vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction. ( 9116637 )
1996
26
Local skin reactivity after induction of Shwartzman reaction in rabbits. ( 7580103 )
1995
27
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. ( 7593621 )
1995
28
Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with Shwartzman reaction. ( 7634712 )
1995
29
Evidence for an essential role of tissue factor dependent blood coagulation in the pathogenesis of the local Shwartzman reaction. ( 7655863 )
1995
30
Acute graft loss secondary to necrotizing vasculitis. Evidence for cytokine-mediated Shwartzman reaction in clinical kidney transplantation. ( 7732554 )
1995
31
Effects of thalidomide on the local Shwartzman reaction in mice and rabbits. ( 8745000 )
1995
32
Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. ( 7510492 )
1994
33
Lesions resulting from attempted Shwartzman reaction in turkey poults inoculated with Pasteurella multocida lipopolysaccharide. ( 7702512 )
1994
34
The effect of SRI 63-675, a competitive platelet-activating factor receptor-antagonist, in the generalized Shwartzman reaction. ( 7812674 )
1994
35
Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. ( 7914909 )
1994
36
Generalized Shwartzman reaction caused by group A beta-hemolytic Streptococcus, resulting in maternal death. A case report. ( 7966050 )
1994
37
Biological activities--lethality, Shwartzman reaction and pyrogenicity--of Salmonella typhimurium porins. ( 8046999 )
1994
38
Prolonged lung edema formation during the generalized Shwartzman reaction in rabbits--can it be a model for septic lung disease? ( 8386987 )
1993
39
Characterization of neutrophil activation by repeated injection of endotoxin in rabbits. Role of neutrophils in the generalized Shwartzman reaction. ( 8454949 )
1993
40
Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited. ( 1345915 )
1992
41
Aminoglycosides modify the in vitro metachromatic reaction and murine generalized Shwartzman phenomenon induced by Salmonella minnesota R595 lipopolysaccharide. ( 1759842 )
1991
42
Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction. ( 1909195 )
1991
43
Fournier's gangrene: the human counterpart of the local Shwartzman phenomenon? ( 2221955 )
1990
44
Effect of cyclosporin on generalized Shwartzman reaction in diabetic rats. ( 2210064 )
1990
45
Shwartzman reaction. ( 2281321 )
1990
46
Tissue plasminogen activator therapy of glomerular thrombi in the Shwartzman reaction. ( 2496256 )
1989
47
Shwartzman reaction in the brain induced by Haemophilus somnus and Escherichia coli lipopolysaccharide in rabbits. ( 2656782 )
1989
48
The effect of Shwartzman phenomenon on the pathogenesis of experimental acute pyelonephritis in rat. ( 3066072 )
1988
49
Shwartzman reaction in the brain induced by fractions of Fusobacterium necrophorum and Escherichia coli lipopolysaccharide in rabbits. ( 3063063 )
1988
50
Stroke risk factors prepare rat brainstem tissues for modified local Shwartzman reaction. ( 3388457 )
1988

Variations for Shwartzman Phenomenon

Expression for Shwartzman Phenomenon

Search GEO for disease gene expression data for Shwartzman Phenomenon.

Pathways for Shwartzman Phenomenon

Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 ESAM F12 F3 ITGAM
2
Show member pathways
12.3 ESAM ITGAM VCAM1
3 11.66 ESAM ITGAM VCAM1
4 11.58 F12 F3 ITGAM
5 11.47 ITGAM TNF
6 11.44 ITGAM TNF
7 11.42 ITGAM TNF
8 11.39 ITGAM TNF VCAM1
9
Show member pathways
11.32 TNF VCAM1
10 11.25 ITGAM TNF
11 11.18 TNF VCAM1
12 11.16 ITGAM TNF
13 11.13 F3 TNF VCAM1
14 11.1 ITGAM VCAM1
15 11 TNF VCAM1
16 10.75 TNF VCAM1
17 10.57 TNF VCAM1
18 10.48 F12 ITGAM TNF

GO Terms for Shwartzman Phenomenon

Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.33 ITGAM TNF VCAM1
2 cell surface GO:0009986 9.26 F3 ITGAM TNF VCAM1
3 extracellular space GO:0005615 9.1 F12 F3 ITGAM SERPINA10 TNF VCAM1

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.58 ITGAM TNF VCAM1
2 leukocyte migration GO:0050900 9.54 ESAM ITGAM TNF
3 blood coagulation GO:0007596 9.5 F12 F3 SERPINA10
4 protein processing GO:0016485 9.43 F12 F3
5 microglial cell activation GO:0001774 9.26 ITGAM TNF
6 cytokine-mediated signaling pathway GO:0019221 9.26 F3 ITGAM TNF VCAM1
7 leukocyte tethering or rolling GO:0050901 9.16 TNF VCAM1
8 hemostasis GO:0007599 8.8 F12 F3 SERPINA10

Sources for Shwartzman Phenomenon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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