MCID: SHW001
MIFTS: 40

Shwartzman Phenomenon

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Shwartzman Phenomenon

MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 12 76 53 44 15 73
Shwartzman Reaction 12 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3825
MeSH 44 D012790
SNOMED-CT 68 24453002
UMLS 73 C0037018

Summaries for Shwartzman Phenomenon

MalaCards based summary : Shwartzman Phenomenon, also known as shwartzman reaction, is related to granulocytopenia and arthus reaction. An important gene associated with Shwartzman Phenomenon is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are NF-kappaB Signaling and RANK Signaling in Osteoclasts. Affiliated tissues include kidney, liver and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Shwartzman phenomenon, also known as Shwartzman reaction, is a rare reaction of a body to particular... more...

Related Diseases for Shwartzman Phenomenon

Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 granulocytopenia 30.1 ITGAM TNF
2 arthus reaction 30.0 ICAM1 TNF
3 vasculitis 30.0 ICAM1 TNF VCAM1
4 systemic lupus erythematosus 29.6 F3 ICAM1 ITGAM TNF VCAM1
5 purpura 10.2
6 penicilliosis 10.1 ITGAM TNF
7 venous insufficiency 10.1 ICAM1 VCAM1
8 grange syndrome 10.1 F3 VCAM1
9 chronic eosinophilic pneumonia 10.1 ICAM1 ITGAM
10 pulmonary immaturity 10.1 F3 VCAM1
11 cortical thymoma 10.1 ICAM1 VCAM1
12 mooren's ulcer 10.1 ICAM1 VCAM1
13 subendocardial myocardial infarction 10.1 ICAM1 VCAM1
14 brachydactyly, type e2 10.1 ICAM1 VCAM1
15 immune-complex glomerulonephritis 10.1 ICAM1 VCAM1
16 leukocyte adhesion deficiency, type i 10.1 ICAM1 ITGAM
17 factor xii deficiency 10.1 F12 F3
18 limbal stem cell deficiency 10.1 ICAM1 VCAM1
19 leukostasis 10.1 ICAM1 VCAM1
20 factor xi deficiency 10.1 F12 F3
21 lupus erythematosus 10.1
22 henoch-schoenlein purpura 10.1 ICAM1 VCAM1
23 arteriosclerosis obliterans 10.1 ICAM1 VCAM1
24 localized scleroderma 10.1 TNF VCAM1
25 crescentic glomerulonephritis 10.1 ICAM1 VCAM1
26 viral encephalitis 10.1 TNF VCAM1
27 crimean-congo hemorrhagic fever 10.1 F3 TNF
28 hemorrhagic fever 10.1 F3 TNF
29 dengue disease 10.1 ICAM1 VCAM1
30 scrub typhus 10.1 F3 TNF
31 oral lichen planus 10.1 ICAM1 VCAM1
32 neutrophil migration 10.1 ICAM1 ITGAM
33 rheumatic heart disease 10.1 TNF VCAM1
34 vertebrobasilar insufficiency 10.1 F3 ICAM1
35 hypersensitivity reaction type iii disease 10.1 ICAM1 TNF
36 poliomyelitis 10.1 ICAM1 TNF
37 lichen disease 10.1 ICAM1 TNF
38 erythema multiforme 10.1 ICAM1 TNF
39 intracranial hypertension 10.1 F3 TNF
40 hepatitis 10.1
41 salmonellosis 10.1
42 thrombosis 10.1
43 dermatitis 10.1
44 plasmodium vivax malaria 10.0 ICAM1 TNF
45 extrinsic cardiomyopathy 10.0 ICAM1 TNF
46 cutaneous lupus erythematosus 10.0 ICAM1 TNF
47 lepromatous leprosy 10.0 ICAM1 TNF
48 dengue hemorrhagic fever 10.0 F3 TNF
49 autoimmune uveitis 10.0 ICAM1 TNF
50 pleurisy 10.0 ICAM1 TNF

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon

Symptoms & Phenotypes for Shwartzman Phenomenon

MGI Mouse Phenotypes related to Shwartzman Phenomenon:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 F3 ICAM1 ITGAM NFKBIE TNF VCAM1
2 homeostasis/metabolism MP:0005376 9.7 F12 F3 ICAM1 ITGAM SERPINA10 TNF
3 immune system MP:0005387 9.43 F3 ICAM1 ITGAM NFKBIE TNF VCAM1
4 nervous system MP:0003631 9.1 F12 F3 ICAM1 ITGAM SERPINA10 TNF

Drugs & Therapeutics for Shwartzman Phenomenon

Search Clinical Trials , NIH Clinical Center for Shwartzman Phenomenon

Cochrane evidence based reviews: shwartzman phenomenon

Genetic Tests for Shwartzman Phenomenon

Anatomical Context for Shwartzman Phenomenon

MalaCards organs/tissues related to Shwartzman Phenomenon:

41
Kidney, Liver, Lung, Skin, Heart, Endothelial, Neutrophil

Publications for Shwartzman Phenomenon

Articles related to Shwartzman Phenomenon:

(show top 50) (show all 363)
# Title Authors Year
1
Whatever happened to the Shwartzman phenomenon? ( 30409091 )
2018
2
Renal failure due to Capnocytophaga canimorsus generalized Shwartzman reaction from a dog bite (DF-2 nephropathy). ( 24688203 )
2014
3
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. ( 23963134 )
2013
4
The Shwartzman reaction repealed: an interview with Dr. Guido Sireci by Helene F. Rosenberg. ( 17200143 )
2007
5
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. ( 17560833 )
2007
6
The Shwartzman reaction repealed. ( 29350849 )
2007
7
An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. ( 16387840 )
2006
8
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. ( 16930474 )
2006
9
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice. ( 15627978 )
2005
10
Mast cell density during initiation and progression of the local Shwartzman reaction. ( 15021965 )
2004
11
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. ( 15489643 )
2004
12
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. ( 12043882 )
2002
13
Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. ( 10657604 )
2000
14
Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody. ( 10789508 )
2000
15
Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. ( 11104806 )
2000
16
Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized shwartzman reaction and its relationship to apoptosis. ( 10417181 )
1999
17
alpha-MSH reduces vasculitis in the local Shwartzman reaction. ( 10816677 )
1999
18
Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction. ( 9531314 )
1998
19
Involvement of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-8, and interleukin-1 receptor antagonist in acute lung injury caused by local Shwartzman reaction. ( 9051688 )
1997
20
Expression of intercellular adhesion molecule-1 (ICAM-1) on vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction as an experimental disseminated intravascular coagulation model. ( 9215589 )
1997
21
Early graft loss secondary to massive hemorrhagic necrosis following orthotopic liver transplantation. Evidence for cytokine-mediated univisceral Shwartzman reaction. ( 8629299 )
1996
22
Apoptotic cell death of vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction. ( 9116637 )
1996
23
Local skin reactivity after induction of Shwartzman reaction in rabbits. ( 7580103 )
1995
24
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. ( 7593621 )
1995
25
Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with Shwartzman reaction. ( 7634712 )
1995
26
Evidence for an essential role of tissue factor dependent blood coagulation in the pathogenesis of the local Shwartzman reaction. ( 7655863 )
1995
27
Acute graft loss secondary to necrotizing vasculitis. Evidence for cytokine-mediated Shwartzman reaction in clinical kidney transplantation. ( 7732554 )
1995
28
Effects of thalidomide on the local Shwartzman reaction in mice and rabbits. ( 8745000 )
1995
29
Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. ( 7510492 )
1994
30
Lesions resulting from attempted Shwartzman reaction in turkey poults inoculated with Pasteurella multocida lipopolysaccharide. ( 7702512 )
1994
31
The effect of SRI 63-675, a competitive platelet-activating factor receptor-antagonist, in the generalized Shwartzman reaction. ( 7812674 )
1994
32
Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. ( 7914909 )
1994
33
Generalized Shwartzman reaction caused by group A beta-hemolytic Streptococcus, resulting in maternal death. A case report. ( 7966050 )
1994
34
Biological activities--lethality, Shwartzman reaction and pyrogenicity--of Salmonella typhimurium porins. ( 8046999 )
1994
35
Prolonged lung edema formation during the generalized Shwartzman reaction in rabbits--can it be a model for septic lung disease? ( 8386987 )
1993
36
Characterization of neutrophil activation by repeated injection of endotoxin in rabbits. Role of neutrophils in the generalized Shwartzman reaction. ( 8454949 )
1993
37
Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited. ( 1345915 )
1992
38
Aminoglycosides modify the in vitro metachromatic reaction and murine generalized Shwartzman phenomenon induced by Salmonella minnesota R595 lipopolysaccharide. ( 1759842 )
1991
39
Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction. ( 1909195 )
1991
40
Fournier's gangrene: the human counterpart of the local Shwartzman phenomenon? ( 2221955 )
1990
41
Effect of cyclosporin on generalized Shwartzman reaction in diabetic rats. ( 2210064 )
1990
42
Shwartzman reaction. ( 2281321 )
1990
43
Tissue plasminogen activator therapy of glomerular thrombi in the Shwartzman reaction. ( 2496256 )
1989
44
Shwartzman reaction in the brain induced by Haemophilus somnus and Escherichia coli lipopolysaccharide in rabbits. ( 2656782 )
1989
45
The effect of Shwartzman phenomenon on the pathogenesis of experimental acute pyelonephritis in rat. ( 3066072 )
1988
46
Shwartzman reaction in the brain induced by fractions of Fusobacterium necrophorum and Escherichia coli lipopolysaccharide in rabbits. ( 3063063 )
1988
47
Stroke risk factors prepare rat brainstem tissues for modified local Shwartzman reaction. ( 3388457 )
1988
48
Anti-interferon-gamma antibody protects mice against the generalized Shwartzman reaction. ( 3121360 )
1987
49
Attempted induction of local Shwartzman reaction in the chicken. ( 3444988 )
1987
50
Function of phagocytes in experimentally induced colitis in rabbits. II. The Shwartzman phenomenon in the colon. ( 3721594 )
1986

Variations for Shwartzman Phenomenon

Expression for Shwartzman Phenomenon

Search GEO for disease gene expression data for Shwartzman Phenomenon.

Pathways for Shwartzman Phenomenon

Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1 12.32 NFKBIE TNF VCAM1
2
Show member pathways
12.18 ICAM1 NFKBIE VCAM1
3 12.18 ICAM1 TNF VCAM1
4
Show member pathways
12.15 ICAM1 NFKBIE VCAM1
5 12.06 ICAM1 NFKBIE TNF
6
Show member pathways
11.99 F3 NFKBIE TNF
7
Show member pathways
11.91 ICAM1 ITGAM VCAM1
8 11.88 ICAM1 ITGAM VCAM1
9 11.86 F12 F3 ITGAM
10 11.84 ICAM1 TNF VCAM1
11 11.78 F3 ICAM1 VCAM1
12 11.71 ICAM1 TNF VCAM1
13 11.63 ICAM1 TNF VCAM1
14 11.61 ICAM1 ITGAM TNF VCAM1
15 11.45 F3 ICAM1 TNF VCAM1
16 11.39 ICAM1 ITGAM
17 11.38 ITGAM TNF
18 11.37 NFKBIE TNF
19
Show member pathways
11.32 NFKBIE TNF
20 11.32 ICAM1 TNF VCAM1
21 11.31 ICAM1 TNF
22 11.29 ICAM1 ITGAM TNF
23 11.26 ICAM1 VCAM1
24 11.26 F12 ITGAM TNF
25 11.19 ICAM1 ITGAM VCAM1
26 11.04 ICAM1 TNF VCAM1
27 10.92 TNF VCAM1
28
Show member pathways
10.72 ICAM1 NFKBIE TNF VCAM1
29 10.34 ICAM1 TNF VCAM1

GO Terms for Shwartzman Phenomenon

Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 ICAM1 ITGAM TNF VCAM1
2 membrane raft GO:0045121 9.43 ICAM1 ITGAM TNF
3 cell surface GO:0009986 9.35 F3 ICAM1 ITGAM TNF VCAM1
4 extracellular space GO:0005615 9.17 F12 F3 ICAM1 ITGAM SERPINA10 TNF

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.63 ICAM1 ITGAM TNF
2 blood coagulation GO:0007596 9.61 F12 F3 SERPINA10
3 protein processing GO:0016485 9.54 F12 F3
4 response to ionizing radiation GO:0010212 9.52 ICAM1 VCAM1
5 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.51 ICAM1 VCAM1
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.49 ICAM1 TNF
7 leukocyte cell-cell adhesion GO:0007159 9.48 ICAM1 VCAM1
8 microglial cell activation GO:0001774 9.4 ITGAM TNF
9 leukocyte tethering or rolling GO:0050901 9.37 TNF VCAM1
10 hemostasis GO:0007599 9.33 F12 F3 SERPINA10
11 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.32 ICAM1 TNF
12 membrane to membrane docking GO:0022614 9.26 ICAM1 VCAM1
13 extracellular matrix organization GO:0030198 9.26 ICAM1 ITGAM TNF VCAM1
14 cytokine-mediated signaling pathway GO:0019221 9.02 F3 ICAM1 ITGAM TNF VCAM1

Sources for Shwartzman Phenomenon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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