MCID: SHW001
MIFTS: 35

Shwartzman Phenomenon

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Shwartzman Phenomenon

MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 12 75 53 44 15 72
Shwartzman Reaction 12 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3825
MeSH 44 D012790
SNOMED-CT 68 24453002
UMLS 72 C0037018

Summaries for Shwartzman Phenomenon

MalaCards based summary : Shwartzman Phenomenon, also known as shwartzman reaction, is related to granulocytopenia and purpura. An important gene associated with Shwartzman Phenomenon is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Affiliated tissues include skin, kidney and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 75 Shwartzman phenomenon is a rare reaction of a body to particular types of toxins, called endotoxins,... more...

Related Diseases for Shwartzman Phenomenon

Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 granulocytopenia 30.3 TNF ITGAM
2 purpura 30.2 TNF F3
3 pyoderma 30.1 TNF F3
4 systemic lupus erythematosus 29.2 VCAM1 TNF ITGAM F3
5 vascular disease 29.2 VCAM1 TNF ITGAM F3
6 lymphocytic vasculitis 10.4 VCAM1 ITGAM
7 chronic venous insufficiency 10.4 VCAM1 ITGAM
8 toxic shock syndrome 10.4
9 allergic hypersensitivity disease 10.4
10 typhoid fever 10.4
11 grange syndrome 10.3 VCAM1 F3
12 pulmonary immaturity 10.3 VCAM1 F3
13 factor xii deficiency 10.3 F3 F12
14 disseminated intravascular coagulation 10.2
15 diphtheria 10.2
16 factor xi deficiency 10.2 F3 F12
17 hemolytic-uremic syndrome 10.2
18 penicilliosis 10.2 TNF ITGAM
19 actinic prurigo 10.2 VCAM1 TNF
20 rheumatoid vasculitis 10.2 VCAM1 TNF
21 thrombocytopenia 10.2
22 neurotic disorder 10.2
23 pancreatitis 10.2
24 herpes zoster 10.2
25 lupus erythematosus 10.2
26 pemphigus 10.2
27 meningitis 10.2
28 localized scleroderma 10.1 VCAM1 TNF
29 antiphospholipid syndrome 10.1 VCAM1 F3
30 hydrops, lactic acidosis, and sideroblastic anemia 10.1
31 clostridium difficile colitis 10.1
32 salmonellosis 10.1
33 kidney disease 10.1
34 severe combined immunodeficiency 10.1
35 48,xyyy 10.1
36 acute respiratory distress syndrome 10.1
37 cytokine deficiency 10.1
38 peripheral vascular disease 10.1 VCAM1 F3
39 viral encephalitis 10.1 VCAM1 TNF
40 crimean-congo hemorrhagic fever 10.1 TNF F3
41 rheumatic heart disease 10.1 VCAM1 TNF
42 scrub typhus 10.1 TNF F3
43 primary progressive multiple sclerosis 10.0 VCAM1 TNF
44 endocarditis 10.0 VCAM1 TNF
45 takayasu arteritis 10.0 VCAM1 TNF
46 hemangioma-thrombocytopenia syndrome 10.0
47 leprosy 3 10.0
48 ascaris lumbricoides infection 10.0
49 colitis 10.0
50 purpura fulminans 10.0

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon

Symptoms & Phenotypes for Shwartzman Phenomenon

MGI Mouse Phenotypes related to Shwartzman Phenomenon:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ESAM F3 PRDM6 SERPINA10 TNF VCAM1
2 homeostasis/metabolism MP:0005376 9.17 F12 F3 ITGAM PRDM6 SERPINA10 TNF

Drugs & Therapeutics for Shwartzman Phenomenon

Search Clinical Trials , NIH Clinical Center for Shwartzman Phenomenon

Cochrane evidence based reviews: shwartzman phenomenon

Genetic Tests for Shwartzman Phenomenon

Anatomical Context for Shwartzman Phenomenon

MalaCards organs/tissues related to Shwartzman Phenomenon:

41
Skin, Kidney, Liver, Endothelial, Neutrophil, Colon, Lung

Publications for Shwartzman Phenomenon

Articles related to Shwartzman Phenomenon:

(show top 50) (show all 779)
# Title Authors PMID Year
1
Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. 9 38
18424751 2008
2
Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. 9 38
12488365 2003
3
Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction. 38
31269748 2019
4
Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head. 38
31258650 2019
5
Whatever happened to the Shwartzman phenomenon? 38
30409091 2018
6
A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides. 38
29902933 2018
7
Brief Report: Endothelial-Specific X-Box Binding Protein 1 Deficiency Limits Tumor Necrosis Factor-Induced Leukocyte Recruitment and Vasculitis. 38
26245636 2015
8
Renal failure due to Capnocytophaga canimorsus generalized Shwartzman reaction from a dog bite (DF-2 nephropathy). 38
24688203 2014
9
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. 38
23963134 2013
10
The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents. 38
23407995 2013
11
A plausible explanation for male dominance in typhoid ileal perforation. 38
23180972 2012
12
The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat and high-cholesterol diet. 38
21937954 2011
13
How inflammation modulates central nervous system vessel activation and provides targets for intervention--a personal perspective. 38
20955418 2010
14
Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. 38
20559805 2010
15
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. 38
19696743 2009
16
Novel mechanism of C-reactive protein for enhancing mouse liver innate immunity. 38
19444871 2009
17
IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice. 38
18653461 2008
18
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. 38
17641206 2007
19
Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation. 38
17600275 2007
20
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. 38
17560833 2007
21
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. 38
17372019 2007
22
Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock. 38
17046969 2007
23
Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. 38
17380303 2007
24
The Shwartzman reaction repealed: an interview with Dr. Guido Sireci by Helene F. Rosenberg. 38
17200143 2007
25
The Shwartzman reaction repealed. 38
29350849 2007
26
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. 38
16930474 2006
27
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. 38
16864696 2006
28
An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. 38
16387840 2006
29
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. 38
15809354 2005
30
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice. 38
15627978 2005
31
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. 38
15489643 2004
32
Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. 38
15528377 2004
33
Mast cell density during initiation and progression of the local Shwartzman reaction. 38
15021965 2004
34
Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. 38
14557414 2003
35
Disseminated intravascular coagulation. 38
14502252 2003
36
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. 38
12043882 2002
37
Mouse soluble CD14 truncated at amino acid 71 in transgenic mice: preventive effect on endotoxin-mediated toxic shock. 38
12476036 2002
38
Different pathways leading to cutaneous leukocytoclastic vasculitis in mice. 38
11737258 2001
39
Synthesis and immunological activity of water-soluble thalidomide prodrugs. 38
11377186 2001
40
Depletion of plasma factor XIII prevents disseminated intravascular coagulation-induced organ damage. 38
11307816 2001
41
The fibrin intermediate, its place in the fibrinogen-fibrin transformation. 38
11460472 2001
42
Towards a 'human-like' model of tuberculosis: intranasal inoculation of LPS induces intragranulomatous lung necrosis in mice infected aerogenically with Mycobacterium tuberculosis. 38
11169208 2001
43
Pro-coagulant state resulting from high levels of soluble P-selectin in blood. 38
11095738 2000
44
Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. 38
11104806 2000
45
The rôle of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis. Long-term clinical and microbiological observations. 38
10959784 2000
46
In vivo natural killer cell activities revealed by natural killer cell-deficient mice. 38
10694580 2000
47
Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. 38
10657604 2000
48
Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody. 38
10789508 2000
49
alpha-MSH reduces vasculitis in the local Shwartzman reaction. 38
10816677 1999
50
Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized shwartzman reaction and its relationship to apoptosis. 38
10417181 1999

Variations for Shwartzman Phenomenon

Expression for Shwartzman Phenomenon

Search GEO for disease gene expression data for Shwartzman Phenomenon.

Pathways for Shwartzman Phenomenon

Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 ITGAM F3 F12 ESAM
2
Show member pathways
12.3 VCAM1 ITGAM ESAM
3 11.66 VCAM1 ITGAM ESAM
4 11.58 ITGAM F3 F12
5 11.47 TNF ITGAM
6 11.44 TNF ITGAM
7 11.42 TNF ITGAM
8 11.39 VCAM1 TNF ITGAM
9
Show member pathways
11.32 VCAM1 TNF
10 11.26 TNF ITGAM
11 11.18 VCAM1 TNF
12 11.16 TNF ITGAM
13 11.13 VCAM1 TNF F3
14 11.1 VCAM1 ITGAM
15 11 VCAM1 TNF
16 10.75 VCAM1 TNF
17 10.57 VCAM1 TNF
18 10.48 TNF ITGAM F12

GO Terms for Shwartzman Phenomenon

Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.33 VCAM1 TNF ITGAM
2 cell surface GO:0009986 9.26 VCAM1 TNF ITGAM F3
3 extracellular space GO:0005615 9.1 VCAM1 TNF SERPINA10 ITGAM F3 F12

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.58 VCAM1 TNF ITGAM
2 leukocyte migration GO:0050900 9.54 TNF ITGAM ESAM
3 blood coagulation GO:0007596 9.5 SERPINA10 F3 F12
4 protein processing GO:0016485 9.43 F3 F12
5 microglial cell activation GO:0001774 9.26 TNF ITGAM
6 cytokine-mediated signaling pathway GO:0019221 9.26 VCAM1 TNF ITGAM F3
7 leukocyte tethering or rolling GO:0050901 9.16 VCAM1 TNF
8 hemostasis GO:0007599 8.8 SERPINA10 F3 F12

Sources for Shwartzman Phenomenon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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