MCID: SHW001
MIFTS: 37

Shwartzman Phenomenon

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Shwartzman Phenomenon

MalaCards integrated aliases for Shwartzman Phenomenon:

Name: Shwartzman Phenomenon 12 74 52 15 71
Shwartzman Reaction 12 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3825
SNOMED-CT 67 24453002
UMLS 71 C0037018

Summaries for Shwartzman Phenomenon

MalaCards based summary : Shwartzman Phenomenon, also known as shwartzman reaction, is related to granulocytopenia and toxic shock syndrome. An important gene associated with Shwartzman Phenomenon is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, kidney and liver, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 74 Shwartzman phenomenon is a rare reaction of a body to particular types of toxins, called endotoxins,... more...

Related Diseases for Shwartzman Phenomenon

Diseases related to Shwartzman Phenomenon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 granulocytopenia 30.5 TNF ITGAM
2 toxic shock syndrome 30.4 TNF TLR4 F3
3 disseminated intravascular coagulation 30.3 TNF SELE F3
4 allergic hypersensitivity disease 29.7 VCAM1 TNF SELE ICAM1
5 meningitis 29.5 TNF TLR4 ICAM1
6 amebiasis 29.4 TNF TLR4 ICAM1
7 bacterial sepsis 29.4 VCAM1 TNF TLR4 SELE
8 arthus reaction 29.1 TNF ICAM1
9 lung disease 28.9 TNF TLR4 ICAM1 F3
10 vasculitis 28.9 VCAM1 TNF SELE ITGAM ICAM1
11 thrombocytopenia 28.4 TNF TLR4 SELE ITGAM ICAM1 F3
12 vascular disease 27.9 VCAM1 TNF TLR4 SELE ITGAM ICAM1
13 pre-eclampsia 27.9 VCAM1 TNF TLR4 SELE ITGAM ICAM1
14 systemic lupus erythematosus 27.7 VCAM1 TNF TLR4 SELE ITGAM IL2RB
15 typhoid fever 10.4
16 high molecular weight kininogen deficiency 10.3 F3 F12
17 purpura 10.3
18 aspiration pneumonitis 10.3 TNF F3
19 diphtheria 10.3
20 hemolytic-uremic syndrome 10.2
21 oligoarticular juvenile idiopathic arthritis 10.2 TNF IL2RB
22 critical illness polyneuropathy 10.2 SELE F3
23 hantavirus hemorrhagic fever with renal syndrome 10.2 TNF F3
24 neurotic disorder 10.2
25 herpes zoster 10.2
26 pemphigus 10.2
27 metal allergy 10.2 TNF TLR4
28 silo filler's disease 10.1 TLR4 ITGAM
29 x-linked recessive disease 10.1 TNF ITGAM F3
30 spondylarthropathy 10.1 TNF TLR4
31 superficial basal cell carcinoma 10.1 TNF TLR4
32 clostridium difficile colitis 10.1
33 salmonellosis 10.1
34 kidney disease 10.1
35 severe combined immunodeficiency 10.1
36 48,xyyy 10.1
37 cytokine deficiency 10.1
38 pustulosis palmaris et plantaris 10.1 TNF SELE
39 tympanosclerosis 10.1 TNF TLR4
40 pneumonic plague 10.1 TNF TLR4
41 chlamydia pneumonia 10.1 TNF TLR4
42 idiopathic neutropenia 10.1 TNF TLR4
43 african tick-bite fever 10.1 TNF SELE
44 dental pulp disease 10.0 TNF TLR4
45 pneumonic tularemia 10.0 TNF TLR4 ITGAM
46 epididymis disease 10.0 TNF TLR4
47 taeniasis 10.0 TNF TLR4
48 listeriosis 10.0 TNF TLR4 ITGAM
49 hemangioma-thrombocytopenia syndrome 10.0
50 leprosy 3 10.0

Graphical network of the top 20 diseases related to Shwartzman Phenomenon:



Diseases related to Shwartzman Phenomenon

Symptoms & Phenotypes for Shwartzman Phenomenon

MGI Mouse Phenotypes related to Shwartzman Phenomenon:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 DUSP10 F3 ICAM1 IL2RB ITGAM SELE
2 cardiovascular system MP:0005385 9.92 F3 ICAM1 SELE SERPINA10 TLR4 TNF
3 homeostasis/metabolism MP:0005376 9.85 F12 F3 ICAM1 ITGAM SELE SERPINA10
4 immune system MP:0005387 9.65 DUSP10 F3 ICAM1 IL2RB ITGAM SELE
5 integument MP:0010771 9.17 F3 ICAM1 IL2RB SELE TLR4 TNF

Drugs & Therapeutics for Shwartzman Phenomenon

Search Clinical Trials , NIH Clinical Center for Shwartzman Phenomenon

Genetic Tests for Shwartzman Phenomenon

Anatomical Context for Shwartzman Phenomenon

MalaCards organs/tissues related to Shwartzman Phenomenon:

40
Skin, Kidney, Liver, Endothelial, Neutrophil, Colon, Lung

Publications for Shwartzman Phenomenon

Articles related to Shwartzman Phenomenon:

(show top 50) (show all 779)
# Title Authors PMID Year
1
Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. 54 61
18424751 2008
2
Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. 54 61
12488365 2003
3
Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction. 61
31269748 2019
4
Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head. 61
31258650 2019
5
Whatever happened to the Shwartzman phenomenon? 61
30409091 2018
6
A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides. 61
29902933 2018
7
Brief Report: Endothelial-Specific X-Box Binding Protein 1 Deficiency Limits Tumor Necrosis Factor-Induced Leukocyte Recruitment and Vasculitis. 61
26245636 2015
8
Renal failure due to Capnocytophaga canimorsus generalized Shwartzman reaction from a dog bite (DF-2 nephropathy). 61
24688203 2014
9
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. 61
23963134 2013
10
The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents. 61
23407995 2013
11
A plausible explanation for male dominance in typhoid ileal perforation. 61
23180972 2012
12
The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat and high-cholesterol diet. 61
21937954 2011
13
How inflammation modulates central nervous system vessel activation and provides targets for intervention--a personal perspective. 61
20955418 2010
14
Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. 61
20559805 2010
15
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. 61
19696743 2009
16
Novel mechanism of C-reactive protein for enhancing mouse liver innate immunity. 61
19444871 2009
17
IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice. 61
18653461 2008
18
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. 61
17641206 2007
19
Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation. 61
17600275 2007
20
Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. 61
17560833 2007
21
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. 61
17372019 2007
22
Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. 61
17380303 2007
23
Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock. 61
17046969 2007
24
The Shwartzman reaction repealed: an interview with Dr. Guido Sireci by Helene F. Rosenberg. 61
17200143 2007
25
The Shwartzman reaction repealed. 61
29350849 2007
26
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. 61
16930474 2006
27
Local Shwartzman reaction in the rat induced by endotoxin and ischemia: potential model for skin necrosis in meningococcemia. 61
16864696 2006
28
An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. 61
16387840 2006
29
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. 61
15809354 2005
30
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice. 61
15627978 2005
31
Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. 61
15489643 2004
32
Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. 61
15528377 2004
33
Mast cell density during initiation and progression of the local Shwartzman reaction. 61
15021965 2004
34
Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. 61
14557414 2003
35
Disseminated intravascular coagulation. 61
14502252 2003
36
Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. 61
12043882 2002
37
Mouse soluble CD14 truncated at amino acid 71 in transgenic mice: preventive effect on endotoxin-mediated toxic shock. 61
12476036 2002
38
Different pathways leading to cutaneous leukocytoclastic vasculitis in mice. 61
11737258 2001
39
Synthesis and immunological activity of water-soluble thalidomide prodrugs. 61
11377186 2001
40
Depletion of plasma factor XIII prevents disseminated intravascular coagulation-induced organ damage. 61
11307816 2001
41
The fibrin intermediate, its place in the fibrinogen-fibrin transformation. 61
11460472 2001
42
Towards a 'human-like' model of tuberculosis: intranasal inoculation of LPS induces intragranulomatous lung necrosis in mice infected aerogenically with Mycobacterium tuberculosis. 61
11169208 2001
43
Pro-coagulant state resulting from high levels of soluble P-selectin in blood. 61
11095738 2000
44
Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. 61
11104806 2000
45
The rôle of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis. Long-term clinical and microbiological observations. 61
10959784 2000
46
In vivo natural killer cell activities revealed by natural killer cell-deficient mice. 61
10694580 2000
47
Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. 61
10657604 2000
48
Exacerbation of vascular endothelial injury in the generalized Shwartzman reaction by the administration of anti-E-selectin antibody. 61
10789508 2000
49
alpha-MSH reduces vasculitis in the local Shwartzman reaction. 61
10816677 1999
50
Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized shwartzman reaction and its relationship to apoptosis. 61
10417181 1999

Variations for Shwartzman Phenomenon

Expression for Shwartzman Phenomenon

Search GEO for disease gene expression data for Shwartzman Phenomenon.

Pathways for Shwartzman Phenomenon

Pathways related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 VCAM1 TREML1 TNF TLR4 LILRA6 ITGAM
2
Show member pathways
13.19 VCAM1 TNF ITGAM IL2RB ICAM1 DUSP10
3
Show member pathways
12.01 VCAM1 ITGAM ICAM1
4 11.98 VCAM1 SELE ITGAM ICAM1
5 11.97 ITGAM F3 F12
6 11.94 VCAM1 TNF SELE ICAM1
7 11.91 VCAM1 TREML1 LILRA6 ICAM1
8 11.89 VCAM1 ICAM1 F3
9 11.87 TNF TLR4 ICAM1
10 11.85 TNF ITGAM IL2RB
11 11.81 VCAM1 TNF ITGAM ICAM1
12 11.78 TNF TLR4 ITGAM
13 11.78 VCAM1 TNF SELE ICAM1
14 11.73 TNF TLR4 ICAM1
15 11.72 VCAM1 TNF TLR4 ICAM1
16 11.66 TNF ITGAM IL2RB
17 11.62 TNF TLR4 ITGAM
18 11.49 TNF TLR4 ITGAM
19
Show member pathways
11.42 VCAM1 TNF SELE ICAM1
20 11.4 TNF ITGAM ICAM1
21 11.37 VCAM1 SELE ICAM1
22 11.35 VCAM1 TNF SELE ICAM1 F3
23 11.34 VCAM1 ITGAM ICAM1
24 11.24 TNF TLR4 ITGAM F12
25 11.02 VCAM1 TNF SELE ICAM1
26 10.98 VCAM1 TNF
27 10.75 VCAM1 TNF ICAM1
28 10.72 VCAM1 TNF TLR4 SELE ICAM1

GO Terms for Shwartzman Phenomenon

Cellular components related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.1 VCAM1 TREML1 TNF TLR4 SELE LILRA6
2 plasma membrane GO:0005886 10.02 VCAM1 TREML1 TNF TLR4 SELE ITGAM
3 integral component of plasma membrane GO:0005887 9.85 VCAM1 TNF TLR4 SELE IL2RB ICAM1
4 extracellular space GO:0005615 9.76 VCAM1 TNF SERPINA10 SELE ITGAM ICAM1
5 membrane raft GO:0045121 9.56 TNF SELE ITGAM ICAM1
6 external side of plasma membrane GO:0009897 9.43 VCAM1 TNF TLR4 ITGAM IL2RB ICAM1
7 cell surface GO:0009986 9.23 VCAM1 TREML1 TNF TLR4 ITGAM IL2RB

Biological processes related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.81 VCAM1 TNF ITGAM ICAM1
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 TNF TLR4 ICAM1
3 leukocyte migration GO:0050900 9.73 TNF SELE ITGAM ICAM1
4 regulation of inflammatory response GO:0050727 9.7 TNF TLR4 SELE
5 apoptotic signaling pathway GO:0097190 9.67 TNF TLR4 ITGAM
6 hemostasis GO:0007599 9.63 SERPINA10 F3 F12
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.59 TNF TLR4
8 positive regulation of chemokine production GO:0032722 9.58 TNF TLR4
9 toll-like receptor 4 signaling pathway GO:0034142 9.58 TLR4 ITGAM
10 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 VCAM1 SELE ICAM1
11 positive regulation of interleukin-8 secretion GO:2000484 9.57 TNF TLR4
12 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.56 TNF ICAM1
13 response to lipopolysaccharide GO:0032496 9.56 TLR4 SELE ICAM1 DUSP10
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.55 TNF TLR4
15 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.54 TNF TLR4
16 cellular response to amyloid-beta GO:1904646 9.54 VCAM1 TLR4 ICAM1
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 TNF TLR4 ICAM1
18 membrane to membrane docking GO:0022614 9.48 VCAM1 ICAM1
19 leukocyte cell-cell adhesion GO:0007159 9.33 VCAM1 SELE ICAM1
20 leukocyte tethering or rolling GO:0050901 9.13 VCAM1 TNF SELE
21 cytokine-mediated signaling pathway GO:0019221 9.1 VCAM1 TNF ITGAM IL2RB ICAM1 F3

Molecular functions related to Shwartzman Phenomenon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 VCAM1 ITGAM ICAM1

Sources for Shwartzman Phenomenon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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