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MCID: SLD003
MIFTS: 49

Sialadenitis

Categories: Rare diseases, Gastrointestinal diseases, Cardiovascular diseases, Oral diseases, Immune diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sialadenitis

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MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 12 76 53 55 44 15 73
Sialoadenitis 12 53
Salivary Gland Inflammation 53
Adenitis, Salivary Gland 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Cardiovascular diseases Oral diseases Immune diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10303
ICD10 33 K11.2 K11.20
ICD9CM 35 527.2
MeSH 44 D012793
UMLS 73 C0037023
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Summaries for Sialadenitis

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NIH Rare Diseases : 53 Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to autoimmune pancreatitis and dacryoadenitis, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Proteoglycans in cancer. The drugs rituximab and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and thyroid, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

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Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 autoimmune pancreatitis 30.8 HLA-DQB1 TNF
2 dacryoadenitis 30.4 AQP5 HSPG2
3 geographic tongue 30.1 HLA-DQB1 TNF
4 sjogren syndrome 29.8 HSPG2 TNFSF13B TRIM21
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 28.9 RAG1 TNFSF13B
6 salivary gland disease 25.1 AQP5 CDSN CNTROB HSPG2 RAG1 TNFSF13B
7 igg4-related dacryoadenitis and sialadenitis 12.1
8 xanthogranulomatous sialadenitis 12.1
9 igg4-related submandibular gland disease 11.3
10 beryllium disease 10.7 HLA-DQB1 TNF
11 cardiac sarcoidosis 10.7 TNC TNF
12 chronic beryllium disease 10.7 HLA-DQB1 TNF
13 idiopathic achalasia 10.7 HLA-DQB1 TNF
14 lichen sclerosus 10.7 HLA-DQB1 TNF
15 cytomegalovirus retinitis 10.7 HLA-DQB1 TNF
16 oligoarticular juvenile idiopathic arthritis 10.6 HLA-DQB1 TNF
17 light chain deposition disease 10.6 MMP2 TNC
18 transverse myelitis 10.6 MMP2 TNF
19 endometritis 10.6 HLA-DQB1 TNF
20 panuveitis 10.6 HLA-DQB1 TNF
21 subacute cutaneous lupus erythematosus 10.5 TNF TRIM21
22 sorsby fundus dystrophy 10.4 MMP2 TIMP3
23 severe hemophilia a 10.4 HLA-DQB1 TNF
24 juvenile pilocytic astrocytoma 10.3 TIMP3 TNC
25 hyperglobulinemic purpura 10.3 HSPG2 TRIM21
26 early-onset schizophrenia 10.3 HTR3A TNF
27 heart block, congenital 10.2 CDSN TRIM21
28 immune system disease 10.2 TNF TNFSF13B TRIM21
29 lymphoma 10.2
30 diffuse infiltrative lymphocytosis syndrome 10.1 CDSN TRIM21
31 aplasia of lacrimal and salivary glands 10.1 AQP5 HSPG2
32 sialolithiasis 10.1
33 exanthem 10.0 HSPG2 TNF TRIM21
34 hepatitis 10.0
35 hepatitis c 10.0
36 pancreatitis 10.0
37 primary sjögren syndrome 10.0 HSPG2 TNFSF13B TRIM21
38 suppurative cholangitis 10.0 CDSN TNF
39 viral encephalitis 10.0 TNF TNFSF13B
40 b-cell lymphomas 10.0
41 thyroiditis 10.0
42 cytomegalovirus infection 9.9 RAG1 TNF
43 arthritis 9.9
44 mumps 9.9
45 retroperitoneal fibrosis 9.9
46 progressive multifocal leukoencephalopathy 9.9 RAG1 TNF
47 hepatitis c virus 9.9
48 cholangitis 9.9
49 rheumatoid arthritis 9.8
50 aging 9.8

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis
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Symptoms & Phenotypes for Sialadenitis

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UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 TNF TRIM21 HSPG2 TIMP3 TNC HTR3A
2 hematopoietic system MP:0005397 10.09 TNF TNFSF13B TRIM21 HSPG2 TIMP3 HTR3A
3 behavior/neurological MP:0005386 10.06 TNF HSPG2 TIMP3 TNC HTR3A AQP5
4 immune system MP:0005387 10.02 TNF TNFSF13B TRIM21 HSPG2 TIMP3 HTR3A
5 mortality/aging MP:0010768 9.91 TNF TRIM21 RAG1 HSPG2 TIMP3 HTR3A
6 integument MP:0010771 9.8 TRIM21 TNF RAG1 HSPG2 TIMP3 HTR3A
7 muscle MP:0005369 9.7 TNF HSPG2 TIMP3 HTR3A AQP5 MMP2
8 respiratory system MP:0005388 9.5 HSPG2 TIMP3 TNF AQP5 MMP2 HLA-DQB1
9 vision/eye MP:0005391 9.1 TNF HSPG2 TIMP3 AQP5 MMP2 RAG1
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Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Immunoglobulin G Phase 1, Phase 2
3 Antibodies Phase 1, Phase 2
4 Immunoglobulins Phase 1, Phase 2
5 Antirheumatic Agents Phase 1, Phase 2
6 Vaccines Phase 2
7 Fluorodeoxyglucose F18 Phase 1
8 Chelating Agents Phase 1
9 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 1
10 Radiopharmaceuticals Phase 1
11
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
12 Analgesics Not Applicable
13 Central Nervous System Depressants Not Applicable
14 Narcotics Not Applicable
15 Analgesics, Opioid Not Applicable
16 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
2 A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sjögren's Syndrome Active, not recruiting NCT02334306 Phase 2
3 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Active, not recruiting NCT03133923 Phase 2
4 A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts Completed NCT02899377 Phase 1
5 Dental Safety Profile of High-Dose Radioiodine Therapy Completed NCT00439478 Radioiodine
6 The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Recruiting NCT01833650 Not Applicable
7 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695
8 Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary Diseases Not yet recruiting NCT02883140
9 Gender and Opioid Consumption Not yet recruiting NCT03006627 Not Applicable postoperative morphine

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

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Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

41
Salivary Gland, T Cells, Thyroid, B Cells, Lymph Node, Tongue, Liver
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Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50) (show all 505)
# Title Authors Year
1
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of SjAPgren's Syndrome. ( 29736173 )
2018
2
Iodine-Associated Sialadenitis: An Inflammatory Condition. ( 29369052 )
2018
3
Nivolumab-induced sialadenitis. ( 29686875 )
2018
4
Iodide-induced Sialadenitis Related to Coronary Angiogram. ( 29478871 )
2018
5
Acute sialadenitis associated with 2017-2018 influenza A infection: A case series. ( 29658106 )
2018
6
Cost-effectiveness of sialendoscopy versus medical management for radioiodine-induced sialadenitis. ( 29602223 )
2018
7
The association with xerostomia from sialadenitis and the jaw osteonecrosis in head and neck cancer population: a nationwide cohort study. ( 29725850 )
2018
8
Incidence of Acute Suppurative Sialadenitis in End-Stage Cancer Patients: A Retrospective Observational Study. ( 29454083 )
2018
9
P2Y<sub>2</sub>R Deletion Ameliorates Sialadenitis in IL-14I+-transgenic Mice. ( 29297959 )
2018
10
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. ( 29656682 )
2018
11
Severe acute postoperative airway compromise secondary to submandibular sialadenitis. ( 29872965 )
2018
12
Stage Classification of IgG4-related dacryoadenitis and sialadenitis by the Serum Cytokine Environment. ( 29385874 )
2018
13
Treatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents. ( 29382364 )
2018
14
Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of SjAPgren syndrome. ( 29750331 )
2018
15
An unusual presentation of subacute necrotizing sialadenitis. ( 29446271 )
2018
16
Non-ionic iodinated contrast-induced sialadenitis with parotid gland sparing in patient of hepatocellular carcinoma. ( 29367371 )
2018
17
Buccal space malignancy in the setting of chronic sialadenitis: A report of 2 cases. ( 29493724 )
2018
18
Sialendoscopic management of autoimmune sialadenitis: a review of literature. ( 28516978 )
2017
19
Sialadenitis following blepharoplasty: An unusual sequelae. ( 28513497 )
2017
20
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
21
Clinical utility of<sup>18</sup>F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4-related sclerosing sialadenitis. ( 28988418 )
2017
22
Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review. ( 28949251 )
2017
23
IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy. ( 28823378 )
2017
24
Bilateral submandibular sialadenitis following influenza A virus infection. ( 28924556 )
2017
25
Xanthomatous sialadenitis: Autoimmune- or treatment-induced lesions? ( 29391721 )
2017
26
Surgeon-Performed Ultrasound for Chronic Obstructive Sialadenitis Helps Predict Sialendoscopic Findings and Outcomes. ( 28871894 )
2017
27
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature. ( 28516348 )
2017
28
Highlight: Understanding radiation sialadenitis. ( 28588084 )
2017
29
Flagellar filament structural protein induces SjAPgren's syndrome-like sialadenitis in mice. ( 28142222 )
2017
30
Point-of-care Ultrasound Diagnosis of Acute Sialolithiasis with Sialadenitis. ( 29849382 )
2017
31
Combined interventional sialendoscopy and intraductal steroid therapy for recurrent sialadenitis in SjAPgren's syndrome: Results of a pilot monocentric trial. ( 28585263 )
2017
32
Pathogenic role of endogenous TNF-I+ in the development of SjAPgren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice. ( 28067896 )
2017
33
Acute sialadenitis as adverse reaction to iodinated contrast. ( 28619517 )
2017
34
18F-FDG PET/CT Features of Chronic Sclerosing Sialadenitis Presenting as Localized IgG4-Related Disease. ( 28060780 )
2017
35
Imaging of sialadenitis. ( 28059621 )
2017
36
Differentiating (131)I Radiation Sialadenitis From Autoimmune (SjAPgren Syndrome) Sialadenitis: Case Report. ( 28499805 )
2017
37
Chronic sialadenitis due to the stone inside the accessory duct of submandibular gland. ( 28337530 )
2017
38
Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis? ( 28516979 )
2017
39
Azathioprine-induce acute submandibular sialadenitis in a patient with Crohn's disease. ( 29150359 )
2017
40
Iodide-Associated Sialadenitis. ( 28249137 )
2017
41
Diffusion-weighted MRI for differentiation between sialadenitis and pleomorphic adenoma. ( 27845594 )
2017
42
Anterior mandibular rehabilitation causing chronic obstructive sialadenitis: ?A series of sialo-CBCT cases and literature review. ( 28740970 )
2017
43
A review of acute postoperative sialadenitis in children. ( 28012533 )
2017
44
Acute unilateral post-operative submandibular sialadenitis following posterior cranial fossa surgery. ( 28584354 )
2017
45
IgG4-related sialadenitis and SjAPgren's syndrome. ( 27318181 )
2016
46
Acute postoperative sialadenitis after retrosigmoid craniotomies. ( 27402408 )
2016
47
IgG4 related sclerosing sialadenitis- a retrospective analysis. ( 27568667 )
2016
48
Tubercular sialadenitis of parotid gland - An extremely rare case series. ( 27998500 )
2016
49
Lipoma of the cheek presenting with recurrent sialadenitis of the right parotid gland: a case report. ( 27809889 )
2016
50
RORI^t antagonist suppresses M3 muscarinic acetylcholine receptor-induced SjAPgren's syndrome-like sialadenitis. ( 27643385 )
2016
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Variations for Sialadenitis

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Expression for Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.
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Pathways for Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 12.91 HLA-DQB1 MMP2 RAG1 TNF TNFSF13B TRIM21
2
Proteoglycans in cancer 37
11.56 HSPG2 MMP2 TIMP3 TNF
3
Rheumatoid arthritis 37
11.39 HLA-DQB1 TNF TNFSF13B
4
Angiogenesis (CST) 4
11.28 MMP2 TIMP3 TNC
5
Matrix Metalloproteinases 1
Show member pathways
 10.92 HSPG2 MMP2 TIMP3 TNF
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GO Terms for Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 HSPG2 MMP2 TIMP3 TNC TNF TNFSF13B
2 extracellular region GO:0005576 9.7 CDSN HSPG2 MMP2 TIMP3 TNC TNF
3 basement membrane GO:0005604 9.13 HSPG2 TIMP3 TNC
4 extracellular matrix GO:0031012 8.92 HSPG2 MMP2 TIMP3 TNC

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.33 HSPG2 MMP2 TNC
2 extracellular matrix organization GO:0030198 9.13 HSPG2 TNC TNF
3 immune response GO:0006955 8.92 HLA-DQB1 RAG1 TNF TNFSF13B

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.73 AQP5 CNTROB HLA-DQB1 HSPG2 HTR3A MMP2
2 tumor necrosis factor receptor binding GO:0005164 8.62 TNF TNFSF13B
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Sources for Sialadenitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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