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MCID: SLD003
MIFTS: 49

Sialadenitis

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sialadenitis

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MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 12 76 53 55 44 15 73
Sialoadenitis 12 53
Salivary Gland Inflammation 53
Adenitis, Salivary Gland 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Immune diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10303
ICD10 33 K11.2 K11.20
ICD9CM 35 527.2
MeSH 44 D012793
SNOMED-CT 68 42982001
UMLS 73 C0037023
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Summaries for Sialadenitis

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NIH Rare Diseases : 53 Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to dacryoadenitis and hyperglobulinemic purpura, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Proteoglycans in cancer. The drugs rituximab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

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Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 dacryoadenitis 30.6 HSPG2 AQP5
2 hyperglobulinemic purpura 29.9 TRIM21 HSPG2
3 geographic tongue 29.8 TNF HLA-DQB1
4 keratoconjunctivitis sicca 29.7 TNF HSPG2
5 sjogren syndrome 29.6 TROVE2 TRIM21 TNFSF13B HSPG2 AQP5
6 cutaneous lupus erythematosus 29.6 TROVE2 TRIM21 TNF
7 lupus erythematosus 29.6 TROVE2 TRIM21 TNF
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.5 TNFSF13B RAG1
9 xanthogranulomatous sialadenitis 12.3
10 mikulicz disease 11.7
11 igg4-related submandibular gland disease 11.4
12 lymphoma 10.3
13 sialolithiasis 10.3
14 beryllium disease 10.2 TNF HLA-DQB1
15 chronic graft versus host disease 10.2 TNFSF13B TNF
16 chronic beryllium disease 10.2 TNF HLA-DQB1
17 idiopathic achalasia 10.2 TNF HLA-DQB1
18 cardiac sarcoidosis 10.2 TNF HLA-DQB1
19 microscopic colitis 10.2 TNF HLA-DQB1
20 mumps 10.2
21 light chain deposition disease 10.2 TNC MMP2
22 cytomegalovirus retinitis 10.2 TNF HLA-DQB1
23 oligoarticular juvenile idiopathic arthritis 10.2 TNF HLA-DQB1
24 transverse myelitis 10.2 TNF MMP2
25 glaucomatocyclitic crisis 10.2 TNF HLA-DQB1
26 subacute cutaneous lupus erythematosus 10.2 TRIM21 TNF
27 endometritis 10.2 TNF HLA-DQB1
28 hepatitis 10.2
29 hepatitis c 10.2
30 diffuse infiltrative lymphocytosis syndrome 10.1 TRIM21 TNF
31 b-cell lymphomas 10.1
32 pancreatitis 10.1
33 juvenile pilocytic astrocytoma 10.1 TNC TIMP3
34 panuveitis 10.1 TNF HLA-DQB1
35 xerophthalmia 10.1 TRIM21 HSPG2
36 sorsby fundus dystrophy 10.1 TIMP3 MMP2
37 arthritis 10.1
38 retroperitoneal fibrosis 10.1
39 immune system disease 10.1 TRIM21 TNFSF13B TNF
40 heart block, congenital 10.1 TROVE2 TRIM21
41 viral encephalitis 10.1 TNFSF13B TNF
42 aplasia of lacrimal and salivary glands 10.1 HSPG2 AQP5
43 hepatitis c virus 10.0
44 cholangitis 10.0
45 exanthem 10.0 TRIM21 TNF HSPG2
46 progressive multifocal leukoencephalopathy 10.0 TNF RAG1
47 cogan syndrome 10.0 TROVE2 TRIM21 TNF
48 common variable immunodeficiency 10.0 TNFSF13B TNF RAG1
49 muscular disease 10.0 TRIM21 TNF HSPG2
50 rheumatoid arthritis 10.0

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis
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Symptoms & Phenotypes for Sialadenitis

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UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.16 HLA-DQB1 HSPG2 HTR3A MMP2 RAG1 TIMP3
2 homeostasis/metabolism MP:0005376 10.13 AQP5 HLA-DQB1 HSPG2 HTR3A MMP2 RAG1
3 immune system MP:0005387 10.1 HLA-DQB1 HSPG2 HTR3A MMP2 RAG1 TIMP3
4 behavior/neurological MP:0005386 10.08 AQP5 HLA-DQB1 HSPG2 HTR3A RAG1 TIMP3
5 mortality/aging MP:0010768 10.02 AQP5 HLA-DQB1 HSPG2 HTR3A MMP2 RAG1
6 integument MP:0010771 9.91 HSPG2 HTR3A RAG1 TIMP3 TNF TRIM21
7 muscle MP:0005369 9.8 AQP5 HLA-DQB1 HSPG2 HTR3A MMP2 TIMP3
8 renal/urinary system MP:0005367 9.63 HLA-DQB1 HTR3A RAG1 TIMP3 TRIM21 TROVE2
9 respiratory system MP:0005388 9.5 AQP5 HLA-DQB1 HSPG2 MMP2 RAG1 TIMP3
10 vision/eye MP:0005391 9.1 AQP5 HSPG2 MMP2 RAG1 TIMP3 TNF
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Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antibodies Phase 1, Phase 2
3 Immunoglobulin G Phase 1, Phase 2
4 Immunoglobulins Phase 1, Phase 2
5 Antirheumatic Agents Phase 1, Phase 2
6 Immunologic Factors Phase 1, Phase 2,Phase 2
7 Vaccines Phase 2
8 Chelating Agents Phase 1
9 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 1
10 Fluorodeoxyglucose F18 Phase 1
11 Radiopharmaceuticals Phase 1
12
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
13 Analgesics Not Applicable
14 Narcotics Not Applicable
15 Central Nervous System Depressants Not Applicable
16 Peripheral Nervous System Agents Not Applicable
17 Analgesics, Opioid Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
2 A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sjögren's Syndrome Completed NCT02334306 Phase 2
3 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Active, not recruiting NCT03133923 Phase 2
4 A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts Completed NCT02899377 Phase 1
5 Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary Diseases Unknown status NCT02883140
6 Gender and Opioid Consumption Unknown status NCT03006627 Not Applicable postoperative morphine
7 The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Completed NCT01833650 Not Applicable
8 Dental Safety Profile of High-Dose Radioiodine Therapy Completed NCT00439478 Radioiodine
9 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

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Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

41
Salivary Gland, Thyroid, T Cells, B Cells, Liver, Tongue, Eye
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Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50) (show all 599)
# Title Authors Year
1
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of SjAPgren's Syndrome. ( 29736173 )
2018
2
Iodine-Associated Sialadenitis: An Inflammatory Condition. ( 29369052 )
2018
3
Nivolumab-induced sialadenitis. ( 29686875 )
2018
4
Iodide-induced Sialadenitis Related to Coronary Angiogram. ( 29478871 )
2018
5
Acute sialadenitis associated with 2017-2018 influenza A infection: A case series. ( 29658106 )
2018
6
Cost-effectiveness of sialendoscopy versus medical management for radioiodine-induced sialadenitis. ( 29602223 )
2018
7
The association with xerostomia from sialadenitis and the jaw osteonecrosis in head and neck cancer population: a nationwide cohort study. ( 29725850 )
2018
8
Incidence of Acute Suppurative Sialadenitis in End-Stage Cancer Patients: A Retrospective Observational Study. ( 29454083 )
2018
9
P2Y<sub>2</sub>R Deletion Ameliorates Sialadenitis in IL-14I+-transgenic Mice. ( 29297959 )
2018
10
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. ( 29656682 )
2018
11
Severe acute postoperative airway compromise secondary to submandibular sialadenitis. ( 29872965 )
2018
12
Stage Classification of IgG4-related dacryoadenitis and sialadenitis by the Serum Cytokine Environment. ( 29385874 )
2018
13
Treatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents. ( 29382364 )
2018
14
Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of SjAPgren syndrome. ( 29750331 )
2018
15
An unusual presentation of subacute necrotizing sialadenitis. ( 29446271 )
2018
16
A comparison of conventional and diffusion-weighted magnetic resonance imaging in the diagnosis of sialadenitis and pleomorphic adenoma. ( 30497909 )
2018
17
Early Therapeutic Intervention for IgG4-related Dacryoadenitis and Sialadenitis: The Balance Between Risk of Observation Only and Therapeutic Adverse Effects. ( 30173184 )
2018
18
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. ( 30354922 )
2018
19
Primary Non-Hodgkin Lymphoma of the Parotid Gland Masquerading Chronic Sialadenitis. ( 30507870 )
2018
20
Bacterial biofilm and chronic sialadenitis, survival outcomes in human papilloma virus positive oral cancer, and long-term use of trimethoprim/sulfamethoxazole in recalcitrant chronic rhinosinusitis. ( 30058521 )
2018
21
Non-ionic iodinated contrast-induced sialadenitis with parotid gland sparing in patient of hepatocellular carcinoma. ( 29367371 )
2018
22
Buccal space malignancy in the setting of chronic sialadenitis: A report of 2 cases. ( 29493724 )
2018
23
Morphological evidence of biofilm in chronic obstructive sialadenitis. ( 29986787 )
2018
24
The Positive Effect of Sialendoscopy with Irrigation Lavage for Sialadenitis without Sialolithiasis or Stenosis. ( 30110688 )
2018
25
An experimental chronic obstructive sialadenitis model by partial ligation of the submandibular duct characterised by sialography, histology, and transmission electron microscopy. ( 30125980 )
2018
26
One-year outcomes of sialendoscopic-assisted salivary duct surgery for sialadenitis without sialolithiasis. ( 30152080 )
2018
27
Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice. ( 30190125 )
2018
28
MyD88 signaling causes autoimmune sialadenitis through formation of high endothelial venules and upregulation of LTβ receptor-mediated signaling. ( 30250175 )
2018
29
Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome. ( 30519241 )
2018
30
Sialendoscopic management of autoimmune sialadenitis: a review of literature. ( 28516978 )
2017
31
Sialadenitis following blepharoplasty: An unusual sequelae. ( 28513497 )
2017
32
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
33
Clinical utility of<sup>18</sup>F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4-related sclerosing sialadenitis. ( 28988418 )
2017
34
Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review. ( 28949251 )
2017
35
IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy. ( 28823378 )
2017
36
Bilateral submandibular sialadenitis following influenza A virus infection. ( 28924556 )
2017
37
Xanthomatous sialadenitis: Autoimmune- or treatment-induced lesions? ( 29391721 )
2017
38
Surgeon-Performed Ultrasound for Chronic Obstructive Sialadenitis Helps Predict Sialendoscopic Findings and Outcomes. ( 28871894 )
2017
39
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature. ( 28516348 )
2017
40
Highlight: Understanding radiation sialadenitis. ( 28588084 )
2017
41
Flagellar filament structural protein induces SjAPgren's syndrome-like sialadenitis in mice. ( 28142222 )
2017
42
Point-of-care Ultrasound Diagnosis of Acute Sialolithiasis with Sialadenitis. ( 29849382 )
2017
43
Combined interventional sialendoscopy and intraductal steroid therapy for recurrent sialadenitis in SjAPgren's syndrome: Results of a pilot monocentric trial. ( 28585263 )
2017
44
Pathogenic role of endogenous TNF-I+ in the development of SjAPgren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice. ( 28067896 )
2017
45
Acute sialadenitis as adverse reaction to iodinated contrast. ( 28619517 )
2017
46
18F-FDG PET/CT Features of Chronic Sclerosing Sialadenitis Presenting as Localized IgG4-Related Disease. ( 28060780 )
2017
47
Imaging of sialadenitis. ( 28059621 )
2017
48
Differentiating (131)I Radiation Sialadenitis From Autoimmune (SjAPgren Syndrome) Sialadenitis: Case Report. ( 28499805 )
2017
49
Chronic sialadenitis due to the stone inside the accessory duct of submandibular gland. ( 28337530 )
2017
50
Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis? ( 28516979 )
2017
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Variations for Sialadenitis

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Expression for Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.
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Pathways for Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 12.99 HLA-DQB1 MMP2 RAG1 TNF TNFSF13B TRIM21
2
Proteoglycans in cancer 37
11.76 HSPG2 MMP2 TIMP3 TNF
3
Rheumatoid arthritis 37
11.5 HLA-DQB1 TNF TNFSF13B
4
Angiogenesis (CST) 4
11.45 MMP2 TIMP3 TNC
5
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.36 HSPG2 MMP2 TNC TNF
6
Matrix Metalloproteinases 1
Show member pathways
 10.92 HSPG2 MMP2 TIMP3 TNF
7
G-protein signaling_Rap2B regulation pathway 22
10.56 HSPG2 TIMP3 TNC TNF TNFSF13B
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GO Terms for Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 HSPG2 MMP2 TIMP3 TNC TNF TNFSF13B
2 basement membrane GO:0005604 9.33 HSPG2 TIMP3 TNC
3 extracellular matrix GO:0031012 9.26 HSPG2 MMP2 TIMP3 TNC
4 collagen-containing extracellular matrix GO:0062023 8.92 HSPG2 MMP2 TIMP3 TNC

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.33 HSPG2 MMP2 TNC
2 extracellular matrix organization GO:0030198 9.13 HSPG2 TNC TNF
3 immune response GO:0006955 8.92 HLA-DQB1 RAG1 TNF TNFSF13B

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TNF TNFSF13B
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Sources for Sialadenitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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