MCID: SLD003
MIFTS: 49

Sialadenitis

Categories: Endocrine diseases, Gastrointestinal diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Sialadenitis

MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 11 19 75 53 43 14 16 71 33
Sialoadenitis 11 19 31 33
Inflammation of Salivary Duct or Gland 33
Inflammation of Salivary Gland 33
Salivary Gland Inflammation 19
Salivary Glandular Adenitis 33
Adenitis, Salivary Gland 19
Salivary Gland Adenitis 33
Sialoangiitis 33
Sialodochitis 33
Sialoangitis 33
Sialitis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:10303
ICD9CM 34 527.2
MeSH 43 D012793
NCIt 49 C26882
SNOMED-CT 68 42982001
ICD10 31 K11.2
ICD11 33 94435020
UMLS 71 C0037023

Summaries for Sialadenitis

GARD: 19 Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones.

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to mikulicz disease and sjogren syndrome, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Rituximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and t cells, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology: 11 A salivary gland disease that is characterized as an infection of the salivary glands.

Wikipedia: 75 Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common... more...

Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 634)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 31.4 TRIM21 TNFSF13B SSB IL13 ICOSLG CD4
2 sjogren syndrome 30.9 TRIM21 TNFSF13B SSB ICOSLG CCR6
3 igg4-related disease 30.7 TNFSF13B IL13 ICOSLG CD4 CCR6
4 parotitis 30.7 TRIM21 SSB MMP2 CD4
5 autoimmune pancreatitis 30.6 ICOSLG CD4 CCR6
6 myelitis 30.4 TNF MMP2 CCR6
7 lymphadenitis 30.3 TNF ICOSLG CCR6
8 keratoconjunctivitis 30.3 TRIM21 TNF IL13 CD80
9 sclerosing cholangitis 30.1 TNF ICOSLG CD4 CCR6
10 cholangitis, primary sclerosing 30.1 TNF ICOSLG CD4 CCR6
11 human cytomegalovirus infection 30.1 TNF CD4 CCR6
12 langerhans cell histiocytosis 30.1 TNF ICOSLG CD34 CCR6
13 spondyloarthropathy 1 30.0 TNF ICOSLG CD4 CCR6
14 common cold 30.0 TNF IL13 ICOSLG CD4 CCR6
15 transverse myelitis 30.0 TRIM21 TNF CD4 CCR6
16 thyroiditis 30.0 TNF HLA-DQB1 CD80
17 lymphoma, mucosa-associated lymphoid type 30.0 TNFSF13B ICOSLG CD80 CD4 CCR6
18 salivary gland disease 29.9 TRIM21 TNFSF13B TNF SSB ICOSLG CD4
19 dacryoadenitis 29.9 TRIM21 TNFSF13B SSB IL13 ICOSLG CD4
20 crohn's disease 29.9 TNF IL13 ICOSLG CD4 CCR6
21 hypersensitivity vasculitis 29.9 TNF ICOSLG CD4 CCR6
22 lymphoma, hodgkin, classic 29.9 TNFSF13B IL13 ICOSLG CD80 CD28 CCR6
23 lymph node tuberculosis 29.9 TNF CD4
24 interstitial lung disease 29.9 TNF IL13 ICOSLG CCR6
25 pharyngitis 29.9 TNF CD4 CCR6
26 arthropathy 29.8 TNF OSM MMP2 CCR6
27 chickenpox 29.8 TNF CD4 CCR6
28 cellulitis 29.8 TNF CD4 CCR6
29 bacterial pneumonia 29.8 TNF ICOSLG CD4 CCR6
30 graves' disease 29.8 IL13 ICOSLG HLA-DQB1 CD80 CD28
31 parotid disease 29.8 TRIM21 TNF SSB CD4
32 viral infectious disease 29.8 TNF IL13 ICOSLG CD4 CD28 CCR6
33 autoimmune glomerulonephritis 29.8 ICOSLG CD4 CCR6
34 proliferative glomerulonephritis 29.8 TNFSF13B ICOSLG CCR6
35 autoimmune disease 29.7 TRIM21 TNFSF13B TNF IL13 ICOSLG HLA-DQB1
36 mononeuritis multiplex 29.7 TRIM21 TNF SSB CD4
37 mononeuropathy 29.7 TRIM21 TNF SSB CD4
38 t cell deficiency 29.7 ICOSLG CD4 CD28 CCR6
39 psoriatic arthritis 29.7 TNF MMP2 IL13 ICOSLG CCR6
40 spondyloarthropathy 29.7 TNF ICOSLG CD4 CCR6
41 exanthem 29.7 TRIM21 TNF ICOSLG CD4 CCR6
42 immune-complex glomerulonephritis 29.7 TNFSF13B ICOSLG CD4
43 spinal cord disease 29.7 TNF ICOSLG CD4 CCR6
44 type 1 diabetes mellitus 29.7 TNF ICOSLG HLA-DQB1 CCR6 CCL20
45 respiratory failure 29.6 TNF IL13 CD4 CCR6
46 allergic disease 29.6 TNF IL13 ICOSLG CD4 CD28 CCR6
47 mycobacterium tuberculosis 1 29.6 TNF ICOSLG CD4 CCR6
48 sarcoidosis 1 29.6 TNF IL13 ICOSLG HLA-DQB1 CD80 CD4
49 peripheral nervous system disease 29.6 TNF MMP2 ICOSLG CD4 CD34 CCR6
50 combined immunodeficiency 29.6 TNF IL13 ICOSLG CD4 CD34 CD28

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis

Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:


salivary gland pain

GenomeRNAi Phenotypes related to Sialadenitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 CCL20 CCL23 CCR6 CD28 CD34 CD4
2 no effect GR00402-S-2 10.17 CCL20 CCL23 CCR6 CD28 CD34 CD4

MGI Mouse Phenotypes related to Sialadenitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.19 CCL20 CCL23 CCR6 CD28 CD34 CD4
2 nervous system MP:0003631 10.13 CCR6 CD28 CD4 CD80 EBI3 HLA-DQB1
3 immune system MP:0005387 10.06 CCR6 CD28 CD34 CD4 CD80 EBI3
4 hematopoietic system MP:0005397 9.89 CCR6 CD28 CD34 CD4 CD80 EBI3
5 integument MP:0010771 9.32 CD28 CD34 CD4 HTR3A IL13 MMP2

Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rituximab Approved Phase 1, Phase 2 174722-31-7
2 Antirheumatic Agents Phase 1, Phase 2
3 Antineoplastic Agents, Immunological Phase 1, Phase 2
4 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

Anatomical Context for Sialadenitis

Organs/tissues related to Sialadenitis:

MalaCards : Salivary Gland, Thyroid, T Cells, B Cells, Lymph Node, Bone Marrow, Tongue

Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 2381)
# Title Authors PMID Year
1
Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. 53 62
11302869 2001
2
Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). 53 62
7586691 1995
3
[Autoimmune liver disease complicating Sjögren's syndrome]. 53 62
8531368 1995
4
[Reassessment of usefulness of salivary scintigraphy in diagnosis of Sjögren's syndrome]. 53 62
8385717 1993
5
Sensitization against pancreatic antigen in Sjögren's syndrome and chronic pancreatitis. Preliminary communication. 53 62
1379949 1992
6
Central Diabetes Insipidus Due to IgG4-related Hypophysitis That Required over One Year to Reach the Final Diagnosis Due to Symptoms Being Masked by Sialadenitis. 62
35569983 2022
7
Epidemiologic, radiologic, and sialendoscopic aspects in chronic obstructive sialadenitis. 62
35680655 2022
8
High-fat diet aggravates experimental autoimmune pancreatitis through the activation of type I interferon signaling pathways. 62
36403482 2022
9
IgG4-related sialadenitis - a rare bilateral submandibular gland enlargement: case report. 62
35028774 2022
10
Contrast-Induced Sialadenitis: A Forgotten Complication of Coronary Angiography. 62
36438432 2022
11
Conventional and MR-sialography of accessory submandibular glands: A case report. 62
36212752 2022
12
Drain-Less Submandibular Gland Excision With Preserved Facial Artery. 62
36453599 2022
13
Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy. 62
36329045 2022
14
Primary Hyper-IgE-Related Salivary Gland Disease: A New Disease Entity. 62
35199865 2022
15
Developments in Clinical management of Sialadenitis in Africa. 62
32955360 2022
16
Immunoglobulin G4-related disease with Marked Eosinophilia: A Case Report and Literature Review. 62
36351576 2022
17
NOR-1 (NR4A3) immunostaining on cytologic preparations for the preoperative diagnosis of acinic cell carcinoma of the salivary gland. 62
36058827 2022
18
The disturbance of the distribution of T helper cell subsets in the mantle area surrounding germinal centers in immunoglobulin G4-related sclerosing sialadenitis. 62
35902401 2022
19
Alternate-Day Fasting Ameliorates Newly Established Sjögren's Syndrome-like Sialadenitis in Non-Obese Diabetic Mice. 62
36430269 2022
20
Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer. 62
36354236 2022
21
Pediatric Sjögren Syndrome: Case Report On A Rare Entity. 62
36057088 2022
22
[Establishment and application of new techniques for submandibular gland preservation]. 62
36241226 2022
23
Polarized Microscopic Analysis of Picrosirius Red Stained Salivary Gland Pathologies: An Observational Study. 62
35580628 2022
24
Characteristics of Patients with Primary Sjögren's Syndrome and Non-specific Chronic Sialadenitis: A Subtype in Elderly Patients. 62
35867262 2022
25
Ultrasound scoring systems affect the distribution of sialadenitis scores in Sjögren's syndrome: an inter-system reproducibility study. 62
36200944 2022
26
IgG4-positive plasma cells in nonspecific sialadenitis and sialolithiasis. 62
35606412 2022
27
Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study. 62
36258884 2022
28
Validation of a Spanish chronic obstructive sialadenitis quality of life questionnaire (CSOC). 62
36272442 2022
29
Aetiologic diagnosis of coronary artery aneurysm in a patient with pancreatitis, dacryoadenitis, and sialadenitis. 62
36181468 2022
30
Nicotinamide mitigates radiation injury in submandibular gland by protecting mitochondrial structure and functions. 62
35996988 2022
31
NR4A3 fluorescence in situ hybridization analysis in cytologic and surgical specimens of acinic cell carcinoma. 62
35700750 2022
32
The Role of Endothelial Barrier Function in the Fibrosis of Salivary Gland. 62
36112881 2022
33
The prevalence of extra-salivary gland complications in immunoglobulin G4-related sialadenitis. 62
34048116 2022
34
A Case of Mumps Presenting With Unilateral Submandibular Sialadenitis and Laryngeal Edema. 62
36277528 2022
35
Acute Bilateral Swelling of the Parotid Gland After General Anesthesia in Lateral Decubitus Position. 62
36259034 2022
36
Disruption of the intestinal barrier exacerbates experimental autoimmune pancreatitis by promoting the translocation of Staphylococcus sciuri into the pancreas. 62
36044992 2022
37
Immunological characteristics of IgG4-related Kuttner tumors. 62
36107501 2022
38
Antibodies to Both Ro52 and Ro60 for Identifying Sjögren's Syndrome Patients Best Suited for Clinical Trials of Disease-Modifying Therapies. 62
33742788 2022
39
Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB-R signaling. 62
35749642 2022
40
A Unique Presentation of Ectopic Thyroid Tissue: Case Report and Management Principles. 62
36204041 2022
41
Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis. 62
35135925 2022
42
Sensorineural Hearing Loss in Sjögren's Syndrome. 62
36232483 2022
43
Factors Associated With Radioactive Iodine Therapy-Acquired Nasolacrimal Duct Obstruction. 62
35970353 2022
44
New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. 62
36140482 2022
45
A Case of Seronegative Primary Sjögren's Syndrome Complicated by Takayasu Arteritis in a Japanese Girl. 62
35953299 2022
46
TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review. 62
35803499 2022
47
Sphingosylphosphorylcholine ameliorates experimental sjögren's syndrome by regulating salivary gland inflammation and hypofunction, and regulatory B cells. 62
35732207 2022
48
Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren's syndrome: a comparative study. 62
34283264 2022
49
Ultrasonography of IgG4-related dacryoadenitis and sialadenitis: Imaging features and clinical usefulness. 62
34918161 2022
50
IgG4-related disease in pediatric patients: a single-center experience. 62
33978820 2022

Variations for Sialadenitis

Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CCL20 CCR6 CD28 CD34 CD4 CD80
2
Show member pathways
13.68 TNFSF13B TNF TNC TIMP3 OSM IL13
3
Show member pathways
13.54 TNFSF13B TNF OSM IL13 EBI3 CD80
4
Show member pathways
13.46 CCL20 CCL23 CD4 CD80 IL13 TIMP3
5
Show member pathways
13.21 TNFSF13B TNF TIMP3 OSM IL13 CD80
6
Show member pathways
12.98 TRIM21 TNFSF13B TNF OSM MMP2 IL13
7
Show member pathways
12.76 TNFSF13B TNF TIMP3 OSM IL13 CD80
8
Show member pathways
12.5 ICOSLG HLA-DQB1 CD80 CD28
9
Show member pathways
12.33 ICOSLG HLA-DQB1 CD80 CD4 CD28
10
Show member pathways
12.2 CD28 CD4 CD80 HLA-DQB1 ICOSLG
11
Show member pathways
12.07 TNF CD80 CD4 CD28
12 11.94 CD28 CD34 CD4 CD80 TNF
13 11.89 TNF OSM MMP2 IL13
14
Show member pathways
11.85 TNF EBI3 CD80 CD4 CD28
15
Show member pathways
11.82 TNF TIMP3 MMP2
16
Show member pathways
11.77 CD80 CD4 CD28
17 11.77 CD28 CD80 HLA-DQB1 IL13 TNF
18 11.76 TNC TIMP3 MMP2
19 11.69 TNF ICOSLG EBI3 CD80
20 11.68 TNF TNC MMP2
21 11.67 TNF CD4 CD34
22 11.67 TNF IL13 CD4 CD34 CCR6
23 11.59 TNF MMP2 IL13
24 11.49 CD28 CD4 HLA-DQB1 TNF
25 11.47 IL13 CD80 CD4 CD28
26 11.45 TNF CD80 CCL20
27 11.21 TNF IL13 CD4
28 11.17 IL13 CD4 CD28
29 10.38 CD80 CD28
30 10.18 TNFSF13B TNF TNC TIMP3 OSM IL13

GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.26 TNFSF13B TNF TNC TIMP3 OSM MMP2
2 extracellular region GO:0005576 10.2 CCL20 CCL23 CD34 EBI3 IL13 MMP2
3 external side of plasma membrane GO:0009897 9.58 TNF IL13 ICOSLG EBI3 CD80 CD4
4 protein complex involved in cell adhesion GO:0098636 9.26 CD80 CD28

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TNFSF13B TNF IL13 ICOSLG HTR3A CD4
2 positive regulation of interleukin-10 production GO:0032733 9.88 IL13 CD34 CD28
3 T cell proliferation GO:0042098 9.83 TNFSF13B EBI3 CD28
4 T cell costimulation GO:0031295 9.8 CD28 CD80 TNFSF13B
5 peripheral nervous system axon regeneration GO:0014012 9.76 TNC MMP2
6 positive regulation of interleukin-2 production GO:0032743 9.73 CD80 CD4 CD28
7 humoral immune response GO:0006959 9.61 CCR6 CD28 EBI3 HLA-DQB1 TNF
8 immune response GO:0006955 9.6 TNFSF13B TNF OSM IL13 HLA-DQB1 CD80
9 thymocyte migration GO:0072679 9.46 CCR6 CCL20

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.43 CD80 CD4 CD28
2 cytokine activity GO:0005125 9.4 TNFSF13B TNF OSM IL13 EBI3 CCL23

Sources for Sialadenitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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