Sialadenitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SLD003 MIFTS: 47	Sialadenitis Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Sialadenitis

MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis ¹² ⁷³ ²⁰ ⁵⁴ ⁴⁴ ¹⁵ ¹⁷ ⁷⁰

Sialoadenitis ¹² ²⁰ ³²

Salivary Gland Inflammation ²⁰

Adenitis, Salivary Gland ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Immune diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Diseases of salivary glands

Sialoadenitis

External Ids:

Disease Ontology ¹² DOID:10303

ICD9CM ³⁴ 527.2

MeSH ⁴⁴ D012793

NCIt ⁵⁰ C26882

SNOMED-CT ⁶⁷ 42982001

ICD10 ³² K11.2

EFO ¹⁷ EFO_1001179

UMLS ⁷⁰ C0037023

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Summaries for Sialadenitis

GARD : ²⁰ Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to mikulicz disease and igg4-related disease, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and skin, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷³ Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common... more...

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Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 491)

#	Related Disease	Score	Top Affiliating Genes
1	mikulicz disease	32.3	TNFSF13B CD4 CCR6
2	igg4-related disease	31.0	TNFSF13B ICOSLG CCR6
3	parotitis	30.6	TRIM21 SSB CD4
4	autoimmune pancreatitis	30.3	TNFSF13B TNF SPTAN1 CD4
5	transverse myelitis	30.3	TNF ICOSLG CCR6
6	myelitis	30.3	TNF ICOSLG CCR6
7	spondylitis	30.2	TNF ICOSLG CCR6
8	spondyloarthropathy 1	30.2	TNF ICOSLG CCR6
9	graft-versus-host disease	29.9	TNF HLA-DQB1 CD28
10	acquired immunodeficiency syndrome	29.9	TNF CD4 CD34 CCR6
11	crohn's disease	29.9	TNF ICOSLG CD4 CCR6
12	temporal arteritis	29.9	TNF CD4 CCR6
13	lymphadenitis	29.8	TNF ICOSLG CD4 CCR6
14	cholangitis, primary sclerosing	29.8	TNF ICOSLG CD4 CCR6
15	cellulitis	29.8	TNF CD4 CCR6
16	cheilitis	29.8	TNF CD4 CCR6
17	parotid disease	29.8	TRIM21 SSB CD4
18	bacterial pneumonia	29.7	TNF ICOSLG CD4 CCR6
19	lymphoma, mucosa-associated lymphoid type	29.7	TNFSF13B SIGLEC5 ICOSLG CD80 CD4 CCR6
20	lymph node tuberculosis	29.7	TNF CD4
21	t cell deficiency	29.6	ICOSLG CD4 CD28 CCR6
22	peripheral nervous system disease	29.6	TNF ICOSLG CD4 CD34 CCR6
23	thyroid gland disease	29.6	ICOSLG CD4 CCR6
24	klebsiella pneumonia	29.6	TNF ICOSLG CD4 CCR6
25	chickenpox	29.6	TNF ICOSLG CD4 CCR6
26	myasthenia gravis	29.6	TNFSF13B TNF HLA-DQB1 CD80 CD28
27	autoimmune glomerulonephritis	29.6	ICOSLG EBI3 CD4 CCR6
28	graves' disease	29.6	ICOSLG HLA-DQB1 CD80 CD28
29	mononeuritis multiplex	29.6	TRIM21 TNF SSB CD4
30	mononeuropathy	29.6	TRIM21 TNF SSB CD4
31	cutaneous lupus erythematosus	29.5	TRIM21 TNFSF13B TNF RO60
32	exanthem	29.5	TRIM21 TNF ICOSLG CD4 CCR6
33	combined immunodeficiency	29.5	TNF ICOSLG CD4 CD34 CD28 CCR6
34	sarcoidosis 1	29.5	TNF ICOSLG HLA-DQB1 CD80 CD4 CD28
35	salivary gland disease	29.5	TRIM21 TNFSF13B TNF SSB SIGLEC5 ICOSLG
36	colitis	29.4	TNF ICOSLG CD80 CD4 CCR6 CCL20
37	inflammatory bowel disease	29.4	TNF ICOSLG HLA-DQB1 EBI3 CD80 CCR6
38	bacterial infectious disease	29.4	TNF ICOSLG CD80 CD4 CCR6
39	autoimmune disease	29.3	TRIM21 TNFSF13B TNF RO60 ICOSLG HLA-DQB1
40	lymphoma, non-hodgkin, familial	29.3	TNFSF13B ICOSLG CD80 CD4 CD34 CD28
41	disease by infectious agent	29.3	TNF SIGLEC5 ICOSLG CD4 CD28 CCR6
42	sjogren syndrome	29.3	TRIM21 TNFSF13B SSB SPTAN1 RO60 AQP5
43	nervous system disease	29.3	TNF SIGLEC5 ICOSLG CD4 CCR6
44	granulomatosis with polyangiitis	29.2	TNF ICOSLG CD80 CD4 CD34 CD28
45	dacryoadenitis	29.2	SPTAN1 ICOSLG CD4 CCR6 BPIFA2 AQP5
46	systemic scleroderma	29.1	TRIM21 TNF RO60 ICOSLG CD4 CCR6
47	connective tissue disease	29.1	TNFSF13B TNF SSB SIGLEC5 ICOSLG CD4
48	bone inflammation disease	29.0	TNFSF13B TNF ICOSLG CD80 CD4 CD28
49	lupus erythematosus	28.8	TRIM21 TNF SSB RO60 HLA-DQB1 CD80
50	systemic lupus erythematosus	28.1	TRIM21 TNFSF13B TNF SSB RO60 ICOSLG

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Deficiency Anemia
Heart Disease	Hypertension, Essential
Mucocele of Salivary Gland	Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:

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Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:

salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.77	CCR6 CD28 CD34 CD4 CD80 EBI3
2	immune system	MP:0005387	9.44	CCR6 CD28 CD34 CD4 CD80 EBI3

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Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

rituximab

Approved

Phase 1, Phase 2

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

Mabthera

MabThera

Rituxan

rituximab

Rituximab

rituximab-abbs

rituximab-arrx

rituximab-pvvr

Antineoplastic Agents, Immunological

Phase 1, Phase 2

Antirheumatic Agents

Phase 1, Phase 2

Immunologic Factors

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial	Completed	NCT01584388	Phase 1, Phase 2	Rituximab
2	A Randomized Controlled Trial of the Effectiveness of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer	Completed	NCT01833650

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

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Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

MalaCards organs/tissues related to Sialadenitis:

⁴⁰

Salivary Gland, Thyroid, Skin, T Cells, Lymph Node, Liver, Thymus

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Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 2063)

#	Title	Authors	PMID	Year
1	Rare Parotid Gland Diseases. ²⁰	Sanan A...Cognetti DM	26902981	2016
2	Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. ⁵⁴ ⁶¹	Matsumura R...Sueishi M	11302869	2001
3	Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). ⁶¹ ⁵⁴	Hayashi Y...Hamano H	7586691	1995
4	[Autoimmune liver disease complicating Sjögren's syndrome]. ⁶¹ ⁵⁴	Masaki N...Hayashi S	8531368	1995
5	[Reassessment of usefulness of salivary scintigraphy in diagnosis of Sjögren's syndrome]. ⁶¹ ⁵⁴	Kosuda S...Kubo A	8385717	1993
6	Sensitization against pancreatic antigen in Sjögren's syndrome and chronic pancreatitis. Preliminary communication. ⁶¹ ⁵⁴	Nishimori I...Yamamoto Y	1379949	1992
7	Clinical and laboratory features of patients with focal lymphocytic sialadenitis on minor salivary gland biopsy for sicca symptoms: A single-center experience. ⁶¹	Ayesha B...Singh N	33787627	2021
8	P2Y2 receptor antagonism resolves sialadenitis and improves salivary flow in a Sjögren's syndrome mouse model. ⁶¹	Jasmer KJ...Weisman GA	33561807	2021
9	Sialo-cutaneous fistula with ectopic submandibular gland sialolith, revealing a hidden ipsilateral enlarged and elongated styloid process: a consideration based on CT findings. ⁶¹	Wakoh M...Kamio T	32909103	2021
10	Myoepithelial sialadenitis with metachromatic matrix: A diagnostic pitfall. A case of salivary gland swelling in a paediatric patient evaluated by fine needle aspiration cytology. ⁶¹	Ronchi A...Cozzolino I	32931074	2021
11	Sialendoscopy in Chronic Obstructive Sialadenitis Without Sialolithiasis: A Prospective Cohort Study. ⁶¹	Plonowska KA...Chang JL	32988282	2021
12	Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy. ⁶¹	Zhu WX...Yu GY	32621541	2021
13	Acute Sialadenitis After Skull Base Surgery: Systematic Review and Summative Practice Recommendations. ⁶¹	Naylor RM...Van Gompel JJ	33684589	2021
14	IgG4-related Dacryoadenitis and Sialadenitis with Palatal Gland Swelling. ⁶¹	Yoshida M...Nomura T	33583876	2021
15	Systemic amyloidosis manifestation in a patient with psoriatic arthritis. ⁶¹	Souza BCE...Romiti R	33781647	2021
16	Ultrasound-guided core needle biopsy compared with open biopsy: a new diagnostic approach to salivary gland enlargement in Sjögren's syndrome? ⁶¹	Zabotti A...De Vita S	32940706	2021
17	The prevalence of Sjögren's syndrome and sicca symptoms in patients with systemic sclerosis and alpha-smooth muscle actin expression in biopsy specimens from minor salivary glands. ⁶¹	Can G...Akar S	33773524	2021
18	Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren's syndrome-like phenotype in mice. ⁶¹	Nakamura H...Chiorini JA	33658234	2021
19	Glomerulonephritis with severe nephrotic syndrome induced by immune complexes composed of galactose-deficient IgA1 in primary Sjögren's syndrome: a case report. ⁶¹	Nishioka R...Kawano M	33765955	2021
20	Allergy-Related Sialodochitis: A Preliminary Cohort Study. ⁶¹	Zhao YN...Yu GY	33710620	2021
21	Antibodies to both Ro52 and Ro60 may identify Sjögren's syndrome patients best suited for clinical trials of disease-modifying therapies. ⁶¹	Armagan B...Baer AN	33742788	2021
22	Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren's Syndrome Model Mice. ⁶¹	Kurosawa M...Matsushita K	33669065	2021
23	Smad7 attenuates TGF-β-mediated aging-related hypofunction of submandibular glands. ⁶¹	Hu M...Li C	33641444	2021
24	Clinical and Sialographic Imaging Features of 131I Radiation-induced Submandibular Gland Sialadenitis. ⁶¹	Wang X...Cheng Y	32896506	2021
25	Interpretation of the mucous plug through sialendoscopy. ⁶¹	Fusconi M...Gallo A	33547856	2021
26	Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis. ⁶¹	Takahashi Y...Kawano M	33491522	2021
27	Laser-Assisted Lithotripsy With Sialendoscopy: Systematic Review of YO-IFOS Head and Neck Study Group. ⁶¹	Chiesa-Estomba CM...Walvekar RR	32442031	2021
28	Xanthogranulomatous change in a pleomorphic adenoma: An extremely rare variant/degenerative change. Is it fine needle aspiration induced? ⁶¹	Pujani M...Katarya K	32822112	2021
29	Not All Küttner Tumors Are IgG4-Related Disease (IgG4-RD). ⁶¹	Marcus KS...Rajan Kd A	33398685	2021
30	Acute Sialadenitis in Children With Acute Leukemia During Chemotherapy: A Case Series Study. ⁶¹	Toret E...Bor O	33470773	2021
31	Sialadenitis as chickenpox complication in a 6-year-old girl. ⁶¹	Betkiewicz A...Obuchowicz A	33598402	2021
32	Acute submandibular sialadenitis in a patient with Crohn's disease being treated with infliximab. ⁶¹	Blasco Patino F...Navarro E	32718842	2021
33	[Differential bioinformational model for diagnostics of inflammatory and tumor diseases of the parotid salivary gland]. ⁶¹	Maksimov AY...Akinfiev VM	33528952	2021
34	Comparison of general anesthesia and monitored anesthesia care for sialendoscopy procedures. ⁶¹	Mastrolonardo E...Cognetti DM	33125904	2021
35	Office-based salivary gland ductal irrigation in patients with chronic sialoadenitis: A preliminary study. ⁶¹	Chen YC...Hung SH	33148453	2021
36	Improved efficiency of sialendoscopy procedures at an ambulatory surgery center. ⁶¹	Mastrolonardo E...Cognetti DM	33516124	2021
37	Gluten-free diet modulates inflammation in salivary glands and pancreatic islets. ⁶¹	Haupt-Jorgensen M...Pedersen AML	33432638	2021
38	Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases. ⁶¹	Porubsky S...Marx A	33467055	2021
39	Nerve growth factor protects salivary glands from irradiation-induced damage. ⁶¹	Li SS...Li LJ	33189827	2021
40	Sialendoscopy combined with transoral sialodochoplasty for treatment of parotid duct stenosis with megaduct. ⁶¹	Shin GC...Lim JY	33541036	2021
41	Sialocoele associated with the molar salivary gland in a British Shorthair cat. ⁶¹	Kilduff-Taylor A...Dempsey LM	33747538	2021
42	Sarcoidosis Mimicking Chronic Sialadenitis of Parotid Gland. ⁶¹	Shadamarshan R A...Grewal R	33273195	2020
43	Identifying sialoliths through SEM technology. ⁶¹	Gonzalez-Reimers E...Arnay-de-la-Rosa M	33065496	2020
44	Lichenoid sialadenitis in chronic graft versus host disease. ⁶¹	Piacenza Florezi G...Lourenco SV	33423424	2020
45	Idiopathic multicentric Castleman disease with Sjögren's syndrome and secondary membranous nephropathy: a case report and review of the literature. ⁶¹	Pan Y...Wang Y	33276741	2020
46	Differential diagnosis of immunoglobulin G4-related sialadenitis and Kimura's disease of the salivary gland: a comparative case series. ⁶¹	Zhu WX...Yu GY	33384237	2020
47	Giant torus mandibularis causing submandibular duct obstruction and sialadenitis. ⁶¹	Madhavan AA...Verdoorn JT	33307982	2020
48	Diagnostic utility of submandibular and labial salivary gland biopsy in IgG4-related sialadenitis. ⁶¹	Zhang YY...Yu GY	32458243	2020
49	Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute. ⁶¹	Sun T...Torous VF	33296146	2020
50	Lymphoepithelial Carcinoma of Salivary Gland EBV-association in Endemic versus Non-Endemic Patients: A Report of 16 Cases. ⁶¹	Whaley RD...Thompson LDR	32462279	2020

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Genes for Sialadenitis

Genes related to Sialadenitis (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	13.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	Protein Coding	12.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CD34	CD34 Molecule	Protein Coding	10.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	9.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.78	DISEASES inferred ¹⁵ ¹⁵
6	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.96	DISEASES inferred ¹⁵ ¹⁵
7	CD80	CD80 Molecule	Protein Coding	8.54	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11302869
8	CD28	CD28 Molecule	Protein Coding	8.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11302869
9	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	7.82	DISEASES inferred ¹⁵ ¹⁵
10	TRIM21	Tripartite Motif Containing 21	Protein Coding	7.52	DISEASES inferred ¹⁵
11	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	7.26	DISEASES inferred ¹⁵
12	CD4	CD4 Molecule	Protein Coding	6.98	DISEASES inferred ¹⁵
13	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	6.9	DISEASES inferred ¹⁵
14	BPIFA2	BPI Fold Containing Family A Member 2	Protein Coding	6.59	DISEASES inferred ¹⁵
15	AQP5	Aquaporin 5	Protein Coding	6.58	DISEASES inferred ¹⁵
16	RO60	Ro60, Y RNA Binding Protein	Protein Coding	6.54	DISEASES inferred ¹⁵
17	CCL23	C-C Motif Chemokine Ligand 23	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)
18	EBI3	Epstein-Barr Virus Induced 3	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)
19	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)
20	HTR3A	5-Hydroxytryptamine Receptor 3A	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)
21	MMP2	Matrix Metallopeptidase 2	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)
22	OSM	Oncostatin M	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)

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Variations for Sialadenitis

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Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

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Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 24)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.72	TRIM21 TNFSF13B TNF SPTAN1 SIGLEC5 ICOSLG
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.59	TNFSF13B TNF EBI3 CD80 CD4 CD28
3	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.36	TRIM21 SIGLEC5 ICOSLG HLA-DQB1 CD80 CD4
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.31	TNFSF13B TNF CD80 CD4 CD28 CCR6
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.22	TNFSF13B TNF CD80 CD4 CD28 CCR6
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.2	TRIM21 TNFSF13B TNF SPTAN1 HLA-DQB1 EBI3
7	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.69	TNFSF13B TNF ICOSLG HLA-DQB1 CD80 CD4
8	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.53	TNF ICOSLG HLA-DQB1 CD80 CD4 CD28
9	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.3	ICOSLG HLA-DQB1 CD80 CD4 CD28
10	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.23	TNF CCR6 CCL23 CCL20
11	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.09	ICOSLG HLA-DQB1 CD80 CD4 CD28
12	Hematopoietic cell lineage ³⁶	11.83	TNF HLA-DQB1 CD4 CD34
13	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.83	TNF CD80 CD4 CD34 CD28
14	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.75	CD80 CD4 CD28
15	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.71	TNF CD4 CD34 CCR6
16	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.65	TNF CD4 CD34
17	CTLA4 Signaling ⁶³	11.63	HLA-DQB1 CD80 CD4 CD28
18	Cell adhesion molecules ³⁶	11.61	ICOSLG HLA-DQB1 CD80 CD4 CD34 CD28
19	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.6	TNF EBI3 CD80 CD4 CD28
20	Interleukin-10 signaling ⁶⁵	11.44	TNF CD80 CCL20
21	Th2 Differentiation Pathway ⁶⁴	11.41	CD80 CD4 CD28
22	IgA-Producing B Cells in the Intestine ⁶⁴	11.37	TNFSF13B TNF ICOSLG CD28 CCR6
23	Rheumatoid arthritis ³⁶	11.07	TNFSF13B TNF HLA-DQB1 CD80 CD28 CCL20
24	G-protein signaling_Rap2B regulation pathway ²³	10.92	TNFSF13B TNF CD80 CCL23 CCL20

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GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.07	TNFSF13B TNF SIGLEC5 ICOSLG HTR3A HLA-DQB1
2	integral component of plasma membrane	GO:0005887	9.87	TNF HTR3A CD4 CD34 CD28 CCR6
3	cell surface	GO:0009986	9.43	TNF CD80 CD4 CD34 CD28 CCR6
4	external side of plasma membrane	GO:0009897	9.23	TNF ICOSLG EBI3 CD80 CD4 CD34
5	protein complex involved in cell adhesion	GO:0098636	9.16	CD80 CD28

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.8	TNF CD4 CCL23 CCL20
2	cytokine-mediated signaling pathway	GO:0019221	9.8	TNF EBI3 CD80 CD4 CCL20
3	T cell receptor signaling pathway	GO:0050852	9.76	ICOSLG HLA-DQB1 CD4 CD28
4	chemokine-mediated signaling pathway	GO:0070098	9.7	CCR6 CCL23 CCL20
5	T cell activation	GO:0042110	9.61	ICOSLG CD4 CD28
6	positive regulation of T cell proliferation	GO:0042102	9.56	TNFSF13B CD80 CD4 CD28
7	positive regulation of viral entry into host cell	GO:0046598	9.54	TRIM21 CD4
8	positive regulation of interleukin-2 production	GO:0032743	9.54	CD80 CD4 CD28
9	positive regulation of alpha-beta T cell proliferation	GO:0046641	9.51	EBI3 CD28
10	T cell migration	GO:0072678	9.48	CCR6 CCL20
11	humoral immune response	GO:0006959	9.46	TNF EBI3 CD28 CCR6
12	thymocyte migration	GO:0072679	9.32	CCR6 CCL20
13	immune response	GO:0006955	9.28	TNFSF13B TNF HLA-DQB1 CD80 CD4 CD28
14	T cell costimulation	GO:0031295	9.26	TNFSF13B ICOSLG CD80 CD28

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	9.13	CD80 CD4 CD28
2	cytokine activity	GO:0005125	9.02	TNFSF13B TNF EBI3 CCL23 CCL20

Sources

Sources for Sialadenitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia