MCID: SLD003
MIFTS: 47

Sialadenitis

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Oral diseases, Rare diseases

Aliases & Classifications for Sialadenitis

MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 12 73 20 54 44 15 17 70
Sialoadenitis 12 20 32
Salivary Gland Inflammation 20
Adenitis, Salivary Gland 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10303
ICD9CM 34 527.2
MeSH 44 D012793
NCIt 50 C26882
SNOMED-CT 67 42982001
ICD10 32 K11.2
UMLS 70 C0037023

Summaries for Sialadenitis

GARD : 20 Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to mikulicz disease and igg4-related disease, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and skin, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common... more...

Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 491)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 32.3 TNFSF13B CD4 CCR6
2 igg4-related disease 31.0 TNFSF13B ICOSLG CCR6
3 parotitis 30.6 TRIM21 SSB CD4
4 autoimmune pancreatitis 30.3 TNFSF13B TNF SPTAN1 CD4
5 transverse myelitis 30.3 TNF ICOSLG CCR6
6 myelitis 30.3 TNF ICOSLG CCR6
7 spondylitis 30.2 TNF ICOSLG CCR6
8 spondyloarthropathy 1 30.2 TNF ICOSLG CCR6
9 graft-versus-host disease 29.9 TNF HLA-DQB1 CD28
10 acquired immunodeficiency syndrome 29.9 TNF CD4 CD34 CCR6
11 crohn's disease 29.9 TNF ICOSLG CD4 CCR6
12 temporal arteritis 29.9 TNF CD4 CCR6
13 lymphadenitis 29.8 TNF ICOSLG CD4 CCR6
14 cholangitis, primary sclerosing 29.8 TNF ICOSLG CD4 CCR6
15 cellulitis 29.8 TNF CD4 CCR6
16 cheilitis 29.8 TNF CD4 CCR6
17 parotid disease 29.8 TRIM21 SSB CD4
18 bacterial pneumonia 29.7 TNF ICOSLG CD4 CCR6
19 lymphoma, mucosa-associated lymphoid type 29.7 TNFSF13B SIGLEC5 ICOSLG CD80 CD4 CCR6
20 lymph node tuberculosis 29.7 TNF CD4
21 t cell deficiency 29.6 ICOSLG CD4 CD28 CCR6
22 peripheral nervous system disease 29.6 TNF ICOSLG CD4 CD34 CCR6
23 thyroid gland disease 29.6 ICOSLG CD4 CCR6
24 klebsiella pneumonia 29.6 TNF ICOSLG CD4 CCR6
25 chickenpox 29.6 TNF ICOSLG CD4 CCR6
26 myasthenia gravis 29.6 TNFSF13B TNF HLA-DQB1 CD80 CD28
27 autoimmune glomerulonephritis 29.6 ICOSLG EBI3 CD4 CCR6
28 graves' disease 29.6 ICOSLG HLA-DQB1 CD80 CD28
29 mononeuritis multiplex 29.6 TRIM21 TNF SSB CD4
30 mononeuropathy 29.6 TRIM21 TNF SSB CD4
31 cutaneous lupus erythematosus 29.5 TRIM21 TNFSF13B TNF RO60
32 exanthem 29.5 TRIM21 TNF ICOSLG CD4 CCR6
33 combined immunodeficiency 29.5 TNF ICOSLG CD4 CD34 CD28 CCR6
34 sarcoidosis 1 29.5 TNF ICOSLG HLA-DQB1 CD80 CD4 CD28
35 salivary gland disease 29.5 TRIM21 TNFSF13B TNF SSB SIGLEC5 ICOSLG
36 colitis 29.4 TNF ICOSLG CD80 CD4 CCR6 CCL20
37 inflammatory bowel disease 29.4 TNF ICOSLG HLA-DQB1 EBI3 CD80 CCR6
38 bacterial infectious disease 29.4 TNF ICOSLG CD80 CD4 CCR6
39 autoimmune disease 29.3 TRIM21 TNFSF13B TNF RO60 ICOSLG HLA-DQB1
40 lymphoma, non-hodgkin, familial 29.3 TNFSF13B ICOSLG CD80 CD4 CD34 CD28
41 disease by infectious agent 29.3 TNF SIGLEC5 ICOSLG CD4 CD28 CCR6
42 sjogren syndrome 29.3 TRIM21 TNFSF13B SSB SPTAN1 RO60 AQP5
43 nervous system disease 29.3 TNF SIGLEC5 ICOSLG CD4 CCR6
44 granulomatosis with polyangiitis 29.2 TNF ICOSLG CD80 CD4 CD34 CD28
45 dacryoadenitis 29.2 SPTAN1 ICOSLG CD4 CCR6 BPIFA2 AQP5
46 systemic scleroderma 29.1 TRIM21 TNF RO60 ICOSLG CD4 CCR6
47 connective tissue disease 29.1 TNFSF13B TNF SSB SIGLEC5 ICOSLG CD4
48 bone inflammation disease 29.0 TNFSF13B TNF ICOSLG CD80 CD4 CD28
49 lupus erythematosus 28.8 TRIM21 TNF SSB RO60 HLA-DQB1 CD80
50 systemic lupus erythematosus 28.1 TRIM21 TNFSF13B TNF SSB RO60 ICOSLG

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis

Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.77 CCR6 CD28 CD34 CD4 CD80 EBI3
2 immune system MP:0005387 9.44 CCR6 CD28 CD34 CD4 CD80 EBI3

Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
2 A Randomized Controlled Trial of the Effectiveness of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Completed NCT01833650

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

Anatomical Context for Sialadenitis

MalaCards organs/tissues related to Sialadenitis:

40
Salivary Gland, Thyroid, Skin, T Cells, Lymph Node, Liver, Thymus

Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 2063)
# Title Authors PMID Year
1
Rare Parotid Gland Diseases. 20
26902981 2016
2
Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. 54 61
11302869 2001
3
Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). 61 54
7586691 1995
4
[Autoimmune liver disease complicating Sjögren's syndrome]. 61 54
8531368 1995
5
[Reassessment of usefulness of salivary scintigraphy in diagnosis of Sjögren's syndrome]. 61 54
8385717 1993
6
Sensitization against pancreatic antigen in Sjögren's syndrome and chronic pancreatitis. Preliminary communication. 61 54
1379949 1992
7
Clinical and laboratory features of patients with focal lymphocytic sialadenitis on minor salivary gland biopsy for sicca symptoms: A single-center experience. 61
33787627 2021
8
P2Y2 receptor antagonism resolves sialadenitis and improves salivary flow in a Sjögren's syndrome mouse model. 61
33561807 2021
9
Sialo-cutaneous fistula with ectopic submandibular gland sialolith, revealing a hidden ipsilateral enlarged and elongated styloid process: a consideration based on CT findings. 61
32909103 2021
10
Myoepithelial sialadenitis with metachromatic matrix: A diagnostic pitfall. A case of salivary gland swelling in a paediatric patient evaluated by fine needle aspiration cytology. 61
32931074 2021
11
Sialendoscopy in Chronic Obstructive Sialadenitis Without Sialolithiasis: A Prospective Cohort Study. 61
32988282 2021
12
Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy. 61
32621541 2021
13
Acute Sialadenitis After Skull Base Surgery: Systematic Review and Summative Practice Recommendations. 61
33684589 2021
14
IgG4-related Dacryoadenitis and Sialadenitis with Palatal Gland Swelling. 61
33583876 2021
15
Systemic amyloidosis manifestation in a patient with psoriatic arthritis. 61
33781647 2021
16
Ultrasound-guided core needle biopsy compared with open biopsy: a new diagnostic approach to salivary gland enlargement in Sjögren's syndrome? 61
32940706 2021
17
The prevalence of Sjögren's syndrome and sicca symptoms in patients with systemic sclerosis and alpha-smooth muscle actin expression in biopsy specimens from minor salivary glands. 61
33773524 2021
18
Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren's syndrome-like phenotype in mice. 61
33658234 2021
19
Glomerulonephritis with severe nephrotic syndrome induced by immune complexes composed of galactose-deficient IgA1 in primary Sjögren's syndrome: a case report. 61
33765955 2021
20
Allergy-Related Sialodochitis: A Preliminary Cohort Study. 61
33710620 2021
21
Antibodies to both Ro52 and Ro60 may identify Sjögren's syndrome patients best suited for clinical trials of disease-modifying therapies. 61
33742788 2021
22
Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren's Syndrome Model Mice. 61
33669065 2021
23
Smad7 attenuates TGF-β-mediated aging-related hypofunction of submandibular glands. 61
33641444 2021
24
Clinical and Sialographic Imaging Features of 131I Radiation-induced Submandibular Gland Sialadenitis. 61
32896506 2021
25
Interpretation of the mucous plug through sialendoscopy. 61
33547856 2021
26
Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis. 61
33491522 2021
27
Laser-Assisted Lithotripsy With Sialendoscopy: Systematic Review of YO-IFOS Head and Neck Study Group. 61
32442031 2021
28
Xanthogranulomatous change in a pleomorphic adenoma: An extremely rare variant/degenerative change. Is it fine needle aspiration induced? 61
32822112 2021
29
Not All Küttner Tumors Are IgG4-Related Disease (IgG4-RD). 61
33398685 2021
30
Acute Sialadenitis in Children With Acute Leukemia During Chemotherapy: A Case Series Study. 61
33470773 2021
31
Sialadenitis as chickenpox complication in a 6-year-old girl. 61
33598402 2021
32
Acute submandibular sialadenitis in a patient with Crohn's disease being treated with infliximab. 61
32718842 2021
33
[Differential bioinformational model for diagnostics of inflammatory and tumor diseases of the parotid salivary gland]. 61
33528952 2021
34
Comparison of general anesthesia and monitored anesthesia care for sialendoscopy procedures. 61
33125904 2021
35
Office-based salivary gland ductal irrigation in patients with chronic sialoadenitis: A preliminary study. 61
33148453 2021
36
Improved efficiency of sialendoscopy procedures at an ambulatory surgery center. 61
33516124 2021
37
Gluten-free diet modulates inflammation in salivary glands and pancreatic islets. 61
33432638 2021
38
Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases. 61
33467055 2021
39
Nerve growth factor protects salivary glands from irradiation-induced damage. 61
33189827 2021
40
Sialendoscopy combined with transoral sialodochoplasty for treatment of parotid duct stenosis with megaduct. 61
33541036 2021
41
Sialocoele associated with the molar salivary gland in a British Shorthair cat. 61
33747538 2021
42
Sarcoidosis Mimicking Chronic Sialadenitis of Parotid Gland. 61
33273195 2020
43
Identifying sialoliths through SEM technology. 61
33065496 2020
44
Lichenoid sialadenitis in chronic graft versus host disease. 61
33423424 2020
45
Idiopathic multicentric Castleman disease with Sjögren's syndrome and secondary membranous nephropathy: a case report and review of the literature. 61
33276741 2020
46
Differential diagnosis of immunoglobulin G4-related sialadenitis and Kimura's disease of the salivary gland: a comparative case series. 61
33384237 2020
47
Giant torus mandibularis causing submandibular duct obstruction and sialadenitis. 61
33307982 2020
48
Diagnostic utility of submandibular and labial salivary gland biopsy in IgG4-related sialadenitis. 61
32458243 2020
49
Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute. 61
33296146 2020
50
Lymphoepithelial Carcinoma of Salivary Gland EBV-association in Endemic versus Non-Endemic Patients: A Report of 16 Cases. 61
32462279 2020

Variations for Sialadenitis

Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 TRIM21 TNFSF13B TNF SPTAN1 SIGLEC5 ICOSLG
2
Show member pathways
13.59 TNFSF13B TNF EBI3 CD80 CD4 CD28
3
Show member pathways
13.36 TRIM21 SIGLEC5 ICOSLG HLA-DQB1 CD80 CD4
4
Show member pathways
13.31 TNFSF13B TNF CD80 CD4 CD28 CCR6
5
Show member pathways
13.22 TNFSF13B TNF CD80 CD4 CD28 CCR6
6
Show member pathways
13.2 TRIM21 TNFSF13B TNF SPTAN1 HLA-DQB1 EBI3
7
Show member pathways
12.69 TNFSF13B TNF ICOSLG HLA-DQB1 CD80 CD4
8
Show member pathways
12.53 TNF ICOSLG HLA-DQB1 CD80 CD4 CD28
9
Show member pathways
12.3 ICOSLG HLA-DQB1 CD80 CD4 CD28
10
Show member pathways
12.23 TNF CCR6 CCL23 CCL20
11
Show member pathways
12.09 ICOSLG HLA-DQB1 CD80 CD4 CD28
12 11.83 TNF HLA-DQB1 CD4 CD34
13 11.83 TNF CD80 CD4 CD34 CD28
14
Show member pathways
11.75 CD80 CD4 CD28
15 11.71 TNF CD4 CD34 CCR6
16 11.65 TNF CD4 CD34
17 11.63 HLA-DQB1 CD80 CD4 CD28
18 11.61 ICOSLG HLA-DQB1 CD80 CD4 CD34 CD28
19
Show member pathways
11.6 TNF EBI3 CD80 CD4 CD28
20 11.44 TNF CD80 CCL20
21 11.41 CD80 CD4 CD28
22 11.37 TNFSF13B TNF ICOSLG CD28 CCR6
23 11.07 TNFSF13B TNF HLA-DQB1 CD80 CD28 CCL20
24 10.92 TNFSF13B TNF CD80 CCL23 CCL20

GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TNFSF13B TNF SIGLEC5 ICOSLG HTR3A HLA-DQB1
2 integral component of plasma membrane GO:0005887 9.87 TNF HTR3A CD4 CD34 CD28 CCR6
3 cell surface GO:0009986 9.43 TNF CD80 CD4 CD34 CD28 CCR6
4 external side of plasma membrane GO:0009897 9.23 TNF ICOSLG EBI3 CD80 CD4 CD34
5 protein complex involved in cell adhesion GO:0098636 9.16 CD80 CD28

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 TNF CD4 CCL23 CCL20
2 cytokine-mediated signaling pathway GO:0019221 9.8 TNF EBI3 CD80 CD4 CCL20
3 T cell receptor signaling pathway GO:0050852 9.76 ICOSLG HLA-DQB1 CD4 CD28
4 chemokine-mediated signaling pathway GO:0070098 9.7 CCR6 CCL23 CCL20
5 T cell activation GO:0042110 9.61 ICOSLG CD4 CD28
6 positive regulation of T cell proliferation GO:0042102 9.56 TNFSF13B CD80 CD4 CD28
7 positive regulation of viral entry into host cell GO:0046598 9.54 TRIM21 CD4
8 positive regulation of interleukin-2 production GO:0032743 9.54 CD80 CD4 CD28
9 positive regulation of alpha-beta T cell proliferation GO:0046641 9.51 EBI3 CD28
10 T cell migration GO:0072678 9.48 CCR6 CCL20
11 humoral immune response GO:0006959 9.46 TNF EBI3 CD28 CCR6
12 thymocyte migration GO:0072679 9.32 CCR6 CCL20
13 immune response GO:0006955 9.28 TNFSF13B TNF HLA-DQB1 CD80 CD4 CD28
14 T cell costimulation GO:0031295 9.26 TNFSF13B ICOSLG CD80 CD28

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.13 CD80 CD4 CD28
2 cytokine activity GO:0005125 9.02 TNFSF13B TNF EBI3 CCL23 CCL20

Sources for Sialadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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