Sialadenitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones.

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to mikulicz disease and sjogren syndrome, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Rituximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and t cells, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology: ¹¹ A salivary gland disease that is characterized as an infection of the salivary glands.

Wikipedia: ⁷⁵ Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common... more...

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Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 634)

#	Related Disease	Score	Top Affiliating Genes
1	mikulicz disease	31.4	TRIM21 TNFSF13B SSB IL13 ICOSLG CD4
2	sjogren syndrome	30.9	TRIM21 TNFSF13B SSB ICOSLG CCR6
3	igg4-related disease	30.7	TNFSF13B IL13 ICOSLG CD4 CCR6
4	parotitis	30.7	TRIM21 SSB MMP2 CD4
5	autoimmune pancreatitis	30.6	ICOSLG CD4 CCR6
6	myelitis	30.4	TNF MMP2 CCR6
7	lymphadenitis	30.3	TNF ICOSLG CCR6
8	keratoconjunctivitis	30.3	TRIM21 TNF IL13 CD80
9	sclerosing cholangitis	30.1	TNF ICOSLG CD4 CCR6
10	cholangitis, primary sclerosing	30.1	TNF ICOSLG CD4 CCR6
11	human cytomegalovirus infection	30.1	TNF CD4 CCR6
12	langerhans cell histiocytosis	30.1	TNF ICOSLG CD34 CCR6
13	spondyloarthropathy 1	30.0	TNF ICOSLG CD4 CCR6
14	common cold	30.0	TNF IL13 ICOSLG CD4 CCR6
15	transverse myelitis	30.0	TRIM21 TNF CD4 CCR6
16	thyroiditis	30.0	TNF HLA-DQB1 CD80
17	lymphoma, mucosa-associated lymphoid type	30.0	TNFSF13B ICOSLG CD80 CD4 CCR6
18	salivary gland disease	29.9	TRIM21 TNFSF13B TNF SSB ICOSLG CD4
19	dacryoadenitis	29.9	TRIM21 TNFSF13B SSB IL13 ICOSLG CD4
20	crohn's disease	29.9	TNF IL13 ICOSLG CD4 CCR6
21	hypersensitivity vasculitis	29.9	TNF ICOSLG CD4 CCR6
22	lymphoma, hodgkin, classic	29.9	TNFSF13B IL13 ICOSLG CD80 CD28 CCR6
23	lymph node tuberculosis	29.9	TNF CD4
24	interstitial lung disease	29.9	TNF IL13 ICOSLG CCR6
25	pharyngitis	29.9	TNF CD4 CCR6
26	arthropathy	29.8	TNF OSM MMP2 CCR6
27	chickenpox	29.8	TNF CD4 CCR6
28	cellulitis	29.8	TNF CD4 CCR6
29	bacterial pneumonia	29.8	TNF ICOSLG CD4 CCR6
30	graves' disease	29.8	IL13 ICOSLG HLA-DQB1 CD80 CD28
31	parotid disease	29.8	TRIM21 TNF SSB CD4
32	viral infectious disease	29.8	TNF IL13 ICOSLG CD4 CD28 CCR6
33	autoimmune glomerulonephritis	29.8	ICOSLG CD4 CCR6
34	proliferative glomerulonephritis	29.8	TNFSF13B ICOSLG CCR6
35	autoimmune disease	29.7	TRIM21 TNFSF13B TNF IL13 ICOSLG HLA-DQB1
36	mononeuritis multiplex	29.7	TRIM21 TNF SSB CD4
37	mononeuropathy	29.7	TRIM21 TNF SSB CD4
38	t cell deficiency	29.7	ICOSLG CD4 CD28 CCR6
39	psoriatic arthritis	29.7	TNF MMP2 IL13 ICOSLG CCR6
40	spondyloarthropathy	29.7	TNF ICOSLG CD4 CCR6
41	exanthem	29.7	TRIM21 TNF ICOSLG CD4 CCR6
42	immune-complex glomerulonephritis	29.7	TNFSF13B ICOSLG CD4
43	spinal cord disease	29.7	TNF ICOSLG CD4 CCR6
44	type 1 diabetes mellitus	29.7	TNF ICOSLG HLA-DQB1 CCR6 CCL20
45	respiratory failure	29.6	TNF IL13 CD4 CCR6
46	allergic disease	29.6	TNF IL13 ICOSLG CD4 CD28 CCR6
47	mycobacterium tuberculosis 1	29.6	TNF ICOSLG CD4 CCR6
48	sarcoidosis 1	29.6	TNF IL13 ICOSLG HLA-DQB1 CD80 CD4
49	peripheral nervous system disease	29.6	TNF MMP2 ICOSLG CD4 CD34 CCR6
50	combined immunodeficiency	29.6	TNF IL13 ICOSLG CD4 CD34 CD28

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Deficiency Anemia
Heart Disease	Hypertension, Essential
Mucocele of Salivary Gland	Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:

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Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:

salivary gland pain

GenomeRNAi Phenotypes related to Sialadenitis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	CCL20 CCL23 CCR6 CD28 CD34 CD4
2	no effect	GR00402-S-2	10.17	CCL20 CCL23 CCR6 CD28 CD34 CD4

MGI Mouse Phenotypes related to Sialadenitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.19	CCL20 CCL23 CCR6 CD28 CD34 CD4
2	nervous system	MP:0003631	10.13	CCR6 CD28 CD4 CD80 EBI3 HLA-DQB1
3	immune system	MP:0005387	10.06	CCR6 CD28 CD34 CD4 CD80 EBI3
4	hematopoietic system	MP:0005397	9.89	CCR6 CD28 CD34 CD4 CD80 EBI3
5	integument	MP:0010771	9.32	CD28 CD34 CD4 HTR3A IL13 MMP2

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Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rituximab

Approved

Phase 1, Phase 2

174722-31-7

2

Antirheumatic Agents

Phase 1, Phase 2

3

Antineoplastic Agents, Immunological

Phase 1, Phase 2

4

Immunologic Factors

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial	Completed	NCT01584388	Phase 1, Phase 2	Rituximab

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

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Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

Organs/tissues related to Sialadenitis:

MalaCards : Salivary Gland, Thyroid, T Cells, B Cells, Lymph Node, Bone Marrow, Tongue

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Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 2381)

#	Title	Authors	PMID	Year
1	Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. ⁵³ ⁶²	Matsumura R...Sueishi M	11302869	2001
2	Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). ⁵³ ⁶²	Hayashi Y...Hamano H	7586691	1995
3	[Autoimmune liver disease complicating Sjögren's syndrome]. ⁵³ ⁶²	Masaki N...Hayashi S	8531368	1995
4	[Reassessment of usefulness of salivary scintigraphy in diagnosis of Sjögren's syndrome]. ⁵³ ⁶²	Kosuda S...Kubo A	8385717	1993
5	Sensitization against pancreatic antigen in Sjögren's syndrome and chronic pancreatitis. Preliminary communication. ⁵³ ⁶²	Nishimori I...Yamamoto Y	1379949	1992
6	Central Diabetes Insipidus Due to IgG4-related Hypophysitis That Required over One Year to Reach the Final Diagnosis Due to Symptoms Being Masked by Sialadenitis. ⁶²	Iwamoto Y...Kaneto H	35569983	2022
7	Epidemiologic, radiologic, and sialendoscopic aspects in chronic obstructive sialadenitis. ⁶²	Sanchez Barrueco A...Villacampa Auba JM	35680655	2022
8	High-fat diet aggravates experimental autoimmune pancreatitis through the activation of type I interferon signaling pathways. ⁶²	Sekai I...Watanabe T	36403482	2022
9	IgG4-related sialadenitis - a rare bilateral submandibular gland enlargement: case report. ⁶²	Mahmoud R...Peleg O	35028774	2022
10	Contrast-Induced Sialadenitis: A Forgotten Complication of Coronary Angiography. ⁶²	Gergis M...Elguindy A	36438432	2022
11	Conventional and MR-sialography of accessory submandibular glands: A case report. ⁶²	Sabotin RP...Hoffman HT	36212752	2022
12	Drain-Less Submandibular Gland Excision With Preserved Facial Artery. ⁶²	Nofal A...Fouad YA	36453599	2022
13	Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy. ⁶²	Nakamura H...Chiorini JA	36329045	2022
14	Primary Hyper-IgE-Related Salivary Gland Disease: A New Disease Entity. ⁶²	Zhu WX...Yu GY	35199865	2022
15	Developments in Clinical management of Sialadenitis in Africa. ⁶²	Maharaj S...Cassim Z	32955360	2022
16	Immunoglobulin G4-related disease with Marked Eosinophilia: A Case Report and Literature Review. ⁶²	Origuchi T...Kawakami A	36351576	2022
17	NOR-1 (NR4A3) immunostaining on cytologic preparations for the preoperative diagnosis of acinic cell carcinoma of the salivary gland. ⁶²	Krishnan V...Fan X	36058827	2022
18	The disturbance of the distribution of T helper cell subsets in the mantle area surrounding germinal centers in immunoglobulin G4-related sclerosing sialadenitis. ⁶²	Kasashima S...Harada K	35902401	2022
19	Alternate-Day Fasting Ameliorates Newly Established Sjögren's Syndrome-like Sialadenitis in Non-Obese Diabetic Mice. ⁶²	Li D...Zhou J	36430269	2022
20	Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer. ⁶²	Tsur N...Gilat H	36354236	2022
21	Pediatric Sjögren Syndrome: Case Report On A Rare Entity. ⁶²	Santos MF...Nascimento J	36057088	2022
22	[Establishment and application of new techniques for submandibular gland preservation]. ⁶²	Yu GY...Cong X	36241226	2022
23	Polarized Microscopic Analysis of Picrosirius Red Stained Salivary Gland Pathologies: An Observational Study. ⁶²	Juengsomjit R...Janebodin K	35580628	2022
24	Characteristics of Patients with Primary Sjögren's Syndrome and Non-specific Chronic Sialadenitis: A Subtype in Elderly Patients. ⁶²	Li HX...Wu ZB	35867262	2022
25	Ultrasound scoring systems affect the distribution of sialadenitis scores in Sjögren's syndrome: an inter-system reproducibility study. ⁶²	Cafaro G...Bartoloni E	36200944	2022
26	IgG4-positive plasma cells in nonspecific sialadenitis and sialolithiasis. ⁶²	Peuraharju E...Atula T	35606412	2022
27	Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study. ⁶²	Chen YC...Hung SH	36258884	2022
28	Validation of a Spanish chronic obstructive sialadenitis quality of life questionnaire (CSOC). ⁶²	Santillan Coello JM...Cenjor Espanol C	36272442	2022
29	Aetiologic diagnosis of coronary artery aneurysm in a patient with pancreatitis, dacryoadenitis, and sialadenitis. ⁶²	Iaconelli A...Sanna T	36181468	2022
30	Nicotinamide mitigates radiation injury in submandibular gland by protecting mitochondrial structure and functions. ⁶²	Wang XY...Xiang B	35996988	2022
31	NR4A3 fluorescence in situ hybridization analysis in cytologic and surgical specimens of acinic cell carcinoma. ⁶²	Shi Q...Zhou Z	35700750	2022
32	The Role of Endothelial Barrier Function in the Fibrosis of Salivary Gland. ⁶²	Mao XD...Cong X	36112881	2022
33	The prevalence of extra-salivary gland complications in immunoglobulin G4-related sialadenitis. ⁶²	Zhou W...Sun C	34048116	2022
34	A Case of Mumps Presenting With Unilateral Submandibular Sialadenitis and Laryngeal Edema. ⁶²	Ogawa G...Ito K	36277528	2022
35	Acute Bilateral Swelling of the Parotid Gland After General Anesthesia in Lateral Decubitus Position. ⁶²	Chidipothu K...Jadhav JA	36259034	2022
36	Disruption of the intestinal barrier exacerbates experimental autoimmune pancreatitis by promoting the translocation of Staphylococcus sciuri into the pancreas. ⁶²	Yoshikawa T...Watanabe T	36044992	2022
37	Immunological characteristics of IgG4-related Kuttner tumors. ⁶²	Kim SG...Hong YT	36107501	2022
38	Antibodies to Both Ro52 and Ro60 for Identifying Sjögren's Syndrome Patients Best Suited for Clinical Trials of Disease-Modifying Therapies. ⁶²	Armagan B...Baer AN	33742788	2022
39	Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB-R signaling. ⁶²	Chang L...Wang X	35749642	2022
40	A Unique Presentation of Ectopic Thyroid Tissue: Case Report and Management Principles. ⁶²	Sanker V...Tharakan V	36204041	2022
41	Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis. ⁶²	Yamamoto H...Hanaoka M	35135925	2022
42	Sensorineural Hearing Loss in Sjögren's Syndrome. ⁶²	Okawa Y...Ihara K	36232483	2022
43	Factors Associated With Radioactive Iodine Therapy-Acquired Nasolacrimal Duct Obstruction. ⁶²	Lee IT...Sobel RK	35970353	2022
44	New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. ⁶²	Bugala NM...Alexandru DO	36140482	2022
45	A Case of Seronegative Primary Sjögren's Syndrome Complicated by Takayasu Arteritis in a Japanese Girl. ⁶²	Yamanishi S...Itoh Y	35953299	2022
46	TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review. ⁶²	Grange L...Killian M	35803499	2022
47	Sphingosylphosphorylcholine ameliorates experimental sjögren's syndrome by regulating salivary gland inflammation and hypofunction, and regulatory B cells. ⁶²	Kim DS...Park SH	35732207	2022
48	Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren's syndrome: a comparative study. ⁶²	Silva EV...Leon JE	34283264	2022
49	Ultrasonography of IgG4-related dacryoadenitis and sialadenitis: Imaging features and clinical usefulness. ⁶²	Komori T...Gabata T	34918161	2022
50	IgG4-related disease in pediatric patients: a single-center experience. ⁶²	Kaya Akca U...Bilginer Y	33978820	2022

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Genes for Sialadenitis

Genes related to Sialadenitis (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TNF	Tumor Necrosis Factor	Protein Coding	13.2	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	IL13	Interleukin 13	Protein Coding	12.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	11.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	11.15	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	CD34	CD34 Molecule	Protein Coding	10.77	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.67	DISEASES inferred ¹⁴ ¹⁴
7	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.17	DISEASES inferred ¹⁴ ¹⁴
8	CD80	CD80 Molecule	Protein Coding	8.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11302869
9	CD28	CD28 Molecule	Protein Coding	8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11302869
10	TRIM21	Tripartite Motif Containing 21	Protein Coding	7.5	DISEASES inferred ¹⁴
11	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	7.38	DISEASES inferred ¹⁴
12	CCL23	C-C Motif Chemokine Ligand 23	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
13	EBI3	Epstein-Barr Virus Induced 3	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
14	HTR3A	5-Hydroxytryptamine Receptor 3A	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
15	MMP2	Matrix Metallopeptidase 2	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
16	OSM	Oncostatin M	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
17	TIMP3	TIMP Metallopeptidase Inhibitor 3	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
18	TNC	Tenascin C	Protein Coding	7.26	GeneCards inferred via : Publications (show sections)
19	CD4	CD4 Molecule	Protein Coding	6.82	DISEASES inferred ¹⁴
20	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	6.78	DISEASES inferred ¹⁴
21	AQP5	Aquaporin 5	Protein Coding	6.73	DISEASES inferred ¹⁴
22	BPIFA2	BPI Fold Containing Family A Member 2	Protein Coding	6.62	DISEASES inferred ¹⁴
23	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	6.53	DISEASES inferred ¹⁴
24	RO60	Ro60, Y RNA Binding Protein	Protein Coding	6.53	DISEASES inferred ¹⁴
25	ITGAL	Integrin Subunit Alpha L	Protein Coding	6.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7586691

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Variations for Sialadenitis

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Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

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Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.69	CCL20 CCR6 CD28 CD34 CD4 CD80
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.68	TNFSF13B TNF TNC TIMP3 OSM IL13
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.54	TNFSF13B TNF OSM IL13 EBI3 CD80
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.46	CCL20 CCL23 CD4 CD80 IL13 TIMP3
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.21	TNFSF13B TNF TIMP3 OSM IL13 CD80
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.98	TRIM21 TNFSF13B TNF OSM MMP2 IL13
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	12.76	TNFSF13B TNF TIMP3 OSM IL13 CD80
8	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.5	ICOSLG HLA-DQB1 CD80 CD28
9	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ CTLA4 Signaling ⁶⁴ VEGFR2 mediated vascular permeability ⁶⁶	12.33	ICOSLG HLA-DQB1 CD80 CD4 CD28
10	CD28 Signaling in T-Helper Cell ⁶⁴ Show member pathways ICos-ICosL Pathway in T-Helper Cell ⁶⁴	12.2	CD28 CD4 CD80 HLA-DQB1 ICOSLG
11	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.07	TNF CD80 CD4 CD28
12	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.94	CD28 CD34 CD4 CD80 TNF
13	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.89	TNF OSM MMP2 IL13
14	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.85	TNF EBI3 CD80 CD4 CD28
15	Matrix metalloproteinases ⁷⁴ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.82	TNF TIMP3 MMP2
16	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.77	CD80 CD4 CD28
17	Allograft rejection ⁷⁴	11.77	CD28 CD80 HLA-DQB1 IL13 TNF
18	Angiogenesis (CST) ³	11.76	TNC TIMP3 MMP2
19	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.69	TNF ICOSLG EBI3 CD80
20	Burn wound healing ⁷⁴	11.68	TNF TNC MMP2
21	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.67	TNF CD4 CD34
22	Innate Lymphoid Cells Differentiation ⁶⁵	11.67	TNF IL13 CD4 CD34 CCR6
23	Lung fibrosis ⁷⁴	11.59	TNF MMP2 IL13
24	THC Differentiation Pathway ⁶⁴	11.49	CD28 CD4 HLA-DQB1 TNF
25	Th2 Differentiation ⁶⁵	11.47	IL13 CD80 CD4 CD28
26	Interleukin-10 signaling ⁶⁶	11.45	TNF CD80 CCL20
27	Cytokines and inflammatory response ⁷⁴	11.21	TNF IL13 CD4
28	IL12 signaling mediated by STAT4 ⁶¹	11.17	IL13 CD4 CD28
29	FOXP3 in COVID-19 ⁷⁴	10.38	CD80 CD28
30	G-protein signaling_Rap2B regulation pathway ²²	10.18	TNFSF13B TNF TNC TIMP3 OSM IL13

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GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.26	TNFSF13B TNF TNC TIMP3 OSM MMP2
2	extracellular region	GO:0005576	10.2	CCL20 CCL23 CD34 EBI3 IL13 MMP2
3	external side of plasma membrane	GO:0009897	9.58	TNF IL13 ICOSLG EBI3 CD80 CD4
4	protein complex involved in cell adhesion	GO:0098636	9.26	CD80 CD28

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.35	TNFSF13B TNF IL13 ICOSLG HTR3A CD4
2	positive regulation of interleukin-10 production	GO:0032733	9.88	IL13 CD34 CD28
3	T cell proliferation	GO:0042098	9.83	TNFSF13B EBI3 CD28
4	T cell costimulation	GO:0031295	9.8	CD28 CD80 TNFSF13B
5	peripheral nervous system axon regeneration	GO:0014012	9.76	TNC MMP2
6	positive regulation of interleukin-2 production	GO:0032743	9.73	CD80 CD4 CD28
7	humoral immune response	GO:0006959	9.61	CCR6 CD28 EBI3 HLA-DQB1 TNF
8	immune response	GO:0006955	9.6	TNFSF13B TNF OSM IL13 HLA-DQB1 CD80
9	thymocyte migration	GO:0072679	9.46	CCR6 CCL20

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	9.43	CD80 CD4 CD28
2	cytokine activity	GO:0005125	9.4	TNFSF13B TNF OSM IL13 EBI3 CCL23

Sources

Sources for Sialadenitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SLD003 MIFTS: 49	Sialadenitis Categories: Endocrine diseases, Gastrointestinal diseases, Oral diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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