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MCID: SLD003
MIFTS: 49

Sialadenitis

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sialadenitis

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MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 12 77 54 56 45 15 17 74
Sialoadenitis 12 54
Salivary Gland Inflammation 54
Adenitis, Salivary Gland 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Immune diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:10303
ICD9CM 36 527.2
MeSH 45 D012793
SNOMED-CT 69 42982001
ICD10 34 K11.2 K11.20
UMLS 74 C0037023
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Summaries for Sialadenitis

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NIH Rare Diseases : 54 Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to sjogren syndrome and geographic tongue, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs rituximab and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common... more...

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Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 sjogren syndrome 30.1 AQP5 TNFSF13B TRIM21
2 geographic tongue 30.0 HLA-DQB1 TNF
3 rheumatoid arthritis 29.8 CD80 HLA-DQB1 TNF TNFSF13B
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.4 RAG1 TNFSF13B
5 xanthogranulomatous sialadenitis 12.3
6 mikulicz disease 11.8
7 igg4-related submandibular gland disease 11.5
8 beryllium disease 10.4 HLA-DQB1 TNF
9 lymphoma 10.4
10 dacryoadenitis 10.4
11 chronic beryllium disease 10.4 HLA-DQB1 TNF
12 chronic graft versus host disease 10.3 TNF TNFSF13B
13 idiopathic achalasia 10.3 HLA-DQB1 TNF
14 cardiac sarcoidosis 10.3 HLA-DQB1 TNF
15 microscopic colitis 10.3 HLA-DQB1 TNF
16 sialolithiasis 10.3
17 cytomegalovirus retinitis 10.3 HLA-DQB1 TNF
18 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DQB1 TNF
19 transverse myelitis 10.3 MMP2 TNF
20 endometritis 10.3 HLA-DQB1 TNF
21 subacute cutaneous lupus erythematosus 10.3 TNF TRIM21
22 light chain deposition disease 10.3 MMP2 TNC
23 glaucomatocyclitic crisis 10.3 HLA-DQB1 TNF
24 mumps 10.2
25 sorsby fundus dystrophy 10.2 MMP2 TIMP3
26 diffuse infiltrative lymphocytosis syndrome 10.2 TNF TRIM21
27 juvenile ankylosing spondylitis 10.2 CD80 TNF
28 autoimmune disease 10.2 HLA-DQB1 TNF TNFSF13B
29 hepatitis 10.2
30 hepatitis c 10.2
31 pancreatitis 10.2
32 type 1 diabetes mellitus 6 10.2 CD80 HLA-DQB1
33 panuveitis 10.2 HLA-DQB1 TNF
34 spondylarthropathy 10.2 CD80 TNF
35 b-cell lymphomas 10.1
36 juvenile pilocytic astrocytoma 10.1 TIMP3 TNC
37 autoimmune disease of musculoskeletal system 10.1 TNF TNFSF13B TRIM21
38 immune system disease 10.1 TNF TNFSF13B TRIM21
39 arthritis 10.1
40 thyroid cancer 10.1
41 retroperitoneal fibrosis 10.1
42 hepatitis c virus 10.1
43 autoimmune pancreatitis 10.1
44 cholangitis 10.1
45 cogan syndrome 10.0 TNF TRIM21
46 progressive multifocal leukoencephalopathy 10.0 RAG1 TNF
47 glomerulonephritis 10.0
48 igg4-related disease 10.0
49 pleomorphic adenoma 10.0
50 adenoma 10.0

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis
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Symptoms & Phenotypes for Sialadenitis

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UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CD80 EBI3 HLA-DQB1 HTR3A MMP2 RAG1
2 homeostasis/metabolism MP:0005376 10.07 AQP5 EBI3 HLA-DQB1 HTR3A MMP2 RAG1
3 immune system MP:0005387 10.02 CD80 EBI3 HLA-DQB1 HTR3A MMP2 RAG1
4 endocrine/exocrine gland MP:0005379 9.98 AQP5 CD80 HLA-DQB1 HTR3A RAG1 TIMP3
5 mortality/aging MP:0010768 9.91 AQP5 EBI3 HLA-DQB1 HTR3A MMP2 RAG1
6 muscle MP:0005369 9.63 AQP5 HLA-DQB1 HTR3A MMP2 TIMP3 TNF
7 renal/urinary system MP:0005367 9.43 EBI3 HLA-DQB1 HTR3A RAG1 TIMP3 TRIM21
8 respiratory system MP:0005388 9.1 AQP5 HLA-DQB1 MMP2 RAG1 TIMP3 TNF
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Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Vaccines Phase 2
3 Immunologic Factors Phase 2,Phase 1
4 Antibodies Phase 1, Phase 2
5 Antirheumatic Agents Phase 1, Phase 2
6 Antineoplastic Agents, Immunological Phase 1, Phase 2
7 Immunoglobulin G Phase 1, Phase 2
8 Immunoglobulins Phase 1, Phase 2
9 Fluorodeoxyglucose F18 Phase 1
10 Chelating Agents Phase 1
11 Radiopharmaceuticals Phase 1
12 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 1
13
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
14 Analgesics Not Applicable
15 Narcotics Not Applicable
16 Central Nervous System Depressants Not Applicable
17 Peripheral Nervous System Agents Not Applicable
18 Analgesics, Opioid Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Unknown status NCT03133923 Phase 2
2 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
3 A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sjögren's Syndrome Completed NCT02334306 Phase 2
4 A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts Completed NCT02899377 Phase 1
5 Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary Diseases Unknown status NCT02883140
6 Gender and Opioid Consumption Unknown status NCT03006627 Not Applicable postoperative morphine
7 The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Completed NCT01833650 Not Applicable
8 Dental Safety Profile of High-Dose Radioiodine Therapy Completed NCT00439478 Radioiodine
9 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

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Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

42
Salivary Gland, T Cells, Thyroid, B Cells, Lymph Node, Tongue, Endothelial
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Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50) (show all 608)
# Title Authors Year
1
Sialadenitis May Be Associated With an Increased Risk for Osteoradionecrosis: A Nationwide Population-Based Cohort Study. ( 30826391 )
2019
2
Primary Tubercular Sialadenitis - A Diagnostic Dilemma. ( 30783598 )
2019
3
Primary Necrobiotic Xanthogranulomatous Sialadenitis with Submandibular Gland Localization without Skin Involvement: A Case Report and Review. ( 30646671 )
2019
4
Impact of sclerosing dacryoadenitis/sialadenitis on relapse during steroid therapy in patients with type 1 autoimmune pancreatitis. ( 30915865 )
2019
5
Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis: a review. ( 30686634 )
2019
6
The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: its potential application to the diagnostic criteria. ( 30696319 )
2019
7
Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy. ( 30709411 )
2019
8
Iodine-Associated Sialadenitis: An Inflammatory Condition. ( 29369052 )
2018
9
Nivolumab-induced sialadenitis. ( 29686875 )
2018
10
Iodide-induced Sialadenitis Related to Coronary Angiogram. ( 29478871 )
2018
11
Cost-effectiveness of sialendoscopy versus medical management for radioiodine-induced sialadenitis. ( 29602223 )
2018
12
Incidence of Acute Suppurative Sialadenitis in End-Stage Cancer Patients: A Retrospective Observational Study. ( 29454083 )
2018
13
P2Y<sub>2</sub>R Deletion Ameliorates Sialadenitis in IL-14I+-transgenic Mice. ( 29297959 )
2018
14
Stage Classification of IgG4-related dacryoadenitis and sialadenitis by the Serum Cytokine Environment. ( 29385874 )
2018
15
Treatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents. ( 29382364 )
2018
16
Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of SjAPgren syndrome. ( 29750331 )
2018
17
An unusual presentation of subacute necrotizing sialadenitis. ( 29446271 )
2018
18
Non-ionic iodinated contrast-induced sialadenitis with parotid gland sparing in patient of hepatocellular carcinoma. ( 29367371 )
2018
19
A comparison of conventional and diffusion-weighted magnetic resonance imaging in the diagnosis of sialadenitis and pleomorphic adenoma. ( 30497909 )
2018
20
Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome. ( 30519241 )
2018
21
Iodinated contrast-induced sialadenitis: a review of the literature and sonographic findings in a clinical case. ( 30763023 )
2018
22
MyD88 signaling causes autoimmune sialadenitis through formation of high endothelial venules and upregulation of LTβ receptor-mediated signaling. ( 30250175 )
2018
23
Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice. ( 30190125 )
2018
24
One-year outcomes of sialendoscopic-assisted salivary duct surgery for sialadenitis without sialolithiasis. ( 30152080 )
2018
25
An experimental chronic obstructive sialadenitis model by partial ligation of the submandibular duct characterised by sialography, histology, and transmission electron microscopy. ( 30125980 )
2018
26
The Positive Effect of Sialendoscopy with Irrigation Lavage for Sialadenitis without Sialolithiasis or Stenosis. ( 30110688 )
2018
27
Morphological evidence of biofilm in chronic obstructive sialadenitis. ( 29986787 )
2018
28
Bacterial biofilm and chronic sialadenitis, survival outcomes in human papilloma virus positive oral cancer, and long-term use of trimethoprim/sulfamethoxazole in recalcitrant chronic rhinosinusitis. ( 30058521 )
2018
29
Primary Non-Hodgkin Lymphoma of the Parotid Gland Masquerading Chronic Sialadenitis. ( 30507870 )
2018
30
Buccal space malignancy in the setting of chronic sialadenitis: A report of 2 cases. ( 29493724 )
2018
31
Severe acute postoperative airway compromise secondary to submandibular sialadenitis. ( 29872965 )
2018
32
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. ( 29656682 )
2018
33
Early Therapeutic Intervention for IgG4-related Dacryoadenitis and Sialadenitis: The Balance Between Risk of Observation Only and Therapeutic Adverse Effects. ( 30173184 )
2018
34
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. ( 30354922 )
2018
35
The association with xerostomia from sialadenitis and the jaw osteonecrosis in head and neck cancer population: a nationwide cohort study. ( 29725850 )
2018
36
Acute sialadenitis associated with 2017-2018 influenza A infection: A case series. ( 29658106 )
2018
37
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of SjAPgren's Syndrome. ( 29736173 )
2018
38
Sialendoscopic management of autoimmune sialadenitis: a review of literature. ( 28516978 )
2017
39
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
40
Clinical utility of<sup>18</sup>F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4-related sclerosing sialadenitis. ( 28988418 )
2017
41
Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review. ( 28949251 )
2017
42
Bilateral submandibular sialadenitis following influenza A virus infection. ( 28924556 )
2017
43
Surgeon-Performed Ultrasound for Chronic Obstructive Sialadenitis Helps Predict Sialendoscopic Findings and Outcomes. ( 28871894 )
2017
44
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature. ( 28516348 )
2017
45
Highlight: Understanding radiation sialadenitis. ( 28588084 )
2017
46
Flagellar filament structural protein induces SjAPgren's syndrome-like sialadenitis in mice. ( 28142222 )
2017
47
Point-of-care Ultrasound Diagnosis of Acute Sialolithiasis with Sialadenitis. ( 29849382 )
2017
48
Combined interventional sialendoscopy and intraductal steroid therapy for recurrent sialadenitis in SjAPgren's syndrome: Results of a pilot monocentric trial. ( 28585263 )
2017
49
Pathogenic role of endogenous TNF-I+ in the development of SjAPgren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice. ( 28067896 )
2017
50
Acute sialadenitis as adverse reaction to iodinated contrast. ( 28619517 )
2017
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Variations for Sialadenitis

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Expression for Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.
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Pathways for Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.67 CD80 EBI3 HLA-DQB1 MMP2 RAG1 TNF
2
Cytokine Signaling in Immune system 67
Show member pathways
 12.34 CD80 EBI3 HLA-DQB1 MMP2 RAG1 TNF
3
Proteoglycans in cancer 38
11.94 MMP2 TIMP3 TNF
4
Th1 Differentiation Pathway 66
Show member pathways
 11.69 CD80 EBI3 TNF
5
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.64 MMP2 TNC TNF
6
Matrix Metalloproteinases 1
Show member pathways
 11.49 MMP2 TIMP3 TNF
7
Angiogenesis (CST) 4
11.38 MMP2 TIMP3 TNC
8
Rheumatoid arthritis 38
11.22 CD80 HLA-DQB1 TNF TNFSF13B
9
G-protein signaling_RhoB regulation pathway 23
10.84 CD80 TNF TNFSF13B
10
G-protein signaling_Rap2B regulation pathway 23
10.46 CD80 TIMP3 TNC TNF TNFSF13B
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GO Terms for Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 EBI3 MMP2 TIMP3 TNC TNF TNFSF13B

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.02 CD80 HLA-DQB1 RAG1 TNF TNFSF13B

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.4 AQP5 CD80 CNTROB EBI3 HTR3A MMP2
2 cytokine activity GO:0005125 9.33 EBI3 TNF TNFSF13B
3 tumor necrosis factor receptor binding GO:0005164 8.96 TNF TNFSF13B
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Sources for Sialadenitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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