MCID: SLD003
MIFTS: 50

Sialadenitis

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Oral diseases, Rare diseases

Aliases & Classifications for Sialadenitis

MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 12 74 52 54 43 15 17 71
Sialoadenitis 12 52 32
Salivary Gland Inflammation 52
Adenitis, Salivary Gland 52

Classifications:



External Ids:

Disease Ontology 12 DOID:10303
ICD9CM 34 527.2
MeSH 43 D012793
SNOMED-CT 67 42982001
ICD10 32 K11.2 K11.20
UMLS 71 C0037023

Summaries for Sialadenitis

NIH Rare Diseases : 52 Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria . The parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan , MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to mikulicz disease and autoimmune pancreatitis, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common... more...

Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 415)
# Related Disease Score Top Affiliating Genes
1 mikulicz disease 32.9 ICOSLG CD4 CCR6
2 autoimmune pancreatitis 30.8 TNFSF13B TNF CD4
3 igg4-related disease 30.6 TNFSF13B ICOSLG CD4 CCR6
4 sjogren syndrome 30.5 TRIM21 TNFSF13B SSB HSPG2
5 mixed connective tissue disease 30.4 TNFSF13B TNF HSPG2
6 hyperglobulinemic purpura 30.3 TRIM21 HSPG2
7 graft-versus-host disease 30.3 TNF HLA-DQB1 CD28
8 parotitis 30.3 TRIM21 SSB MMP2 CD4
9 spondyloarthropathy 1 30.2 TNF ICOSLG CCR6
10 myelitis 30.2 TNF ICOSLG CCR6
11 chronic graft versus host disease 30.2 TNFSF13B CD4
12 cutaneous lupus erythematosus 30.1 TRIM21 TNFSF13B TNF
13 lymphoma, mucosa-associated lymphoid type 30.1 TNFSF13B CD80 CD4 CCR6
14 temporal arteritis 29.9 TNF CD4 CCR6
15 acquired immunodeficiency syndrome 29.9 TNF CD4 CD34 CCR6
16 cheilitis 29.8 TNF CD4 CCR6
17 t cell deficiency 29.8 CD4 CD28 CCR6
18 lymphadenitis 29.8 TNF ICOSLG CD4 CCR6
19 bacterial pneumonia 29.8 TNF ICOSLG CD4 CCR6
20 cholangitis, primary sclerosing 29.8 TNF ICOSLG CD4 CCR6
21 dacryoadenitis 29.7 ICOSLG HSPG2 CD4 CCR6 BPIFA2
22 parotid disease 29.7 TRIM21 SSB CD4
23 mononeuritis multiplex 29.7 TRIM21 SSB CD4
24 peripheral nervous system disease 29.7 TNF ICOSLG CD4 CCR6
25 dry eye syndrome 29.7 TRIM21 TNF SSB CCR6
26 combined t cell and b cell immunodeficiency 29.6 ICOSLG CD4 CD34 CD28 CCR6
27 cellulitis 29.6 TNF ICOSLG CD4 CCR6
28 autoimmune glomerulonephritis 29.5 ICOSLG EBI3 CD4 CCR6
29 crohn's disease 29.5 TNF ICOSLG CD4 CCR6
30 nervous system disease 29.4 TNF ICOSLG CD4 CCR6
31 autoimmune disease 29.4 TRIM21 TNFSF13B TNF ICOSLG HLA-DQB1 EBI3
32 exanthem 29.3 TRIM21 TNF ICOSLG CD4 CCR6
33 central nervous system disease 29.3 TNF ICOSLG CD4 CCR6
34 salivary gland disease 29.3 TRIM21 TNFSF13B TNF SSB ICOSLG CD4
35 bacterial infectious disease 29.2 TNF ICOSLG CD80 CD4 CCR6
36 rheumatic disease 29.1 TRIM21 TNF SSB OSM ICOSLG CCR6
37 sarcoidosis 1 29.1 TNF ICOSLG HLA-DQB1 CD80 CD4 CD28
38 lupus erythematosus 28.8 TRIM21 TNF SSB HLA-DQB1 CD80 CD28
39 granulomatosis with polyangiitis 28.8 TNFSF13B TNF ICOSLG CD80 CD4 CD28
40 arthritis 28.8 TNFSF13B TNF OSM HLA-DQB1 CD80 CD28
41 bone inflammation disease 28.8 TNF ICOSLG CD80 CD4 CD28 CCR6
42 lymphoma, non-hodgkin, familial 28.7 TNFSF13B TNF ICOSLG CD80 CD4 CD34
43 keratoconjunctivitis sicca 28.6 TRIM21 SSB HSPG2 CD4 CCR6 BPIFA2
44 connective tissue disease 28.6 TNFSF13B TNF SSB ICOSLG HSPG2 CD4
45 xerophthalmia 28.5 TRIM21 TNFSF13B SSB HSPG2 CD4 BPIFA2
46 systemic scleroderma 28.4 TRIM21 TNFSF13B TNF SSB ICOSLG CD4
47 diabetes mellitus, insulin-dependent 28.2 TNF ICOSLG HSPG2 HLA-DQB1 CD80 CD4
48 myeloma, multiple 28.1 TNFSF13B TNF MMP2 ICOSLG CD80 CD4
49 rheumatoid arthritis 27.9 TNFSF13B TNF OSM MMP2 HLA-DQB1 CD80
50 systemic lupus erythematosus 27.5 TRIM21 TNFSF13B TNF SSB ICOSLG HLA-DQB1

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis

Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 CCR6 CD28 CD34 CD4 CD80 EBI3
2 homeostasis/metabolism MP:0005376 10.07 CCR6 CD28 CD34 CD4 EBI3 HLA-DQB1
3 immune system MP:0005387 10.06 CCR6 CD28 CD34 CD4 CD80 EBI3
4 integument MP:0010771 9.61 CD28 CD34 CD4 HSPG2 HTR3A OSM
5 nervous system MP:0003631 9.36 CCR6 CD28 CD4 CD80 HLA-DQB1 HSPG2

Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4
Lenalidomide Approved Phase 1 191732-72-6 216326
5 Angiogenesis Inhibitors Phase 1
6
Silicon Approved, Investigational 7440-21-3 4082203
7
Iodine Approved, Investigational 7553-56-2 807
8 Hemostatics
9 Fluorides
10 cadexomer iodine
11 Immunoglobulin G Early Phase 1
12 Immunoglobulins Early Phase 1
13 Immunologic Factors Early Phase 1
14 Antibodies Early Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
2 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
3 Prospective, Pilot, Comparative, Monocentric Study of Diagnosis Capabilities of the Three-dimensional Cone-Beam CT Sialography (3D-CBCT Sialography) and MRI Sialography in Non-tumor Salivary Diseases Unknown status NCT02883140
4 Recurrent Differentiated Thyroid Cancer: Towards Personalized Treatment Based on Evaluation of Tumor Characteristics With PET (THYROPET Unknown status NCT01641679
5 A Randomized Controlled Trial of the Effectiveness of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Completed NCT01833650
6 The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer Completed NCT00439478 Radioiodine
7 Video Assisted Submandibular Resection, Two Step Technique Completed NCT00798863
8 A Survey of Patients With Elevated Serum IGG4 With Unknown IGG4-related Disease to Whom Biopsy and Performance of Subsequent Specific Staining for Clinical, Laboratory and Pathologic Correlation. Completed NCT02229448
9 A Comparative Study of a Self-adhering Material in Dental Hypersensitivity in Xerostomic Patients Due to Radiotherapy Completed NCT02766127
10 Personalized Treatment Planning for Radio-iodine Therapy of Thyroid Disease Recruiting NCT03517579
11 Characterizing IgG4-related Disease With 68Ga-FAPI PET/CT Not yet recruiting NCT04125511 Early Phase 1 68Ga-FAPI

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

Anatomical Context for Sialadenitis

MalaCards organs/tissues related to Sialadenitis:

40
Salivary Gland, Thyroid, T Cells, B Cells, Skin, Liver, Bone

Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 1951)
# Title Authors PMID Year
1
Rare Parotid Gland Diseases. 52
26902981 2016
2
Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. 54 61
11302869 2001
3
Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). 54 61
7586691 1995
4
[Autoimmune liver disease complicating Sjögren's syndrome]. 54 61
8531368 1995
5
[Reassessment of usefulness of salivary scintigraphy in diagnosis of Sjögren's syndrome]. 54 61
8385717 1993
6
Sensitization against pancreatic antigen in Sjögren's syndrome and chronic pancreatitis. Preliminary communication. 54 61
1379949 1992
7
Catalpol ameliorates Sjögren's Syndrome by modulating interplay of T and B cells. 61
31951976 2020
8
Agonist-induced 4-1BB activation prevents the development of Sjӧgren's syndrome-like sialadenitis in non-obese diabetic mice. 61
31740402 2020
9
Risk of malignancy in "atypia of undetermined significance" category of salivary gland fine-needle aspiration: A bi-institutional experience. 61
31763783 2020
10
Recent advances in the histopathological Assessment of Salivary Disease. 61
32027401 2020
11
Parapharyngeal abscess and vocal cord palsy caused by minor salivary gland sialadenitis: an atypical presentation treated using an endoscopic surgical approach. 61
31538802 2020
12
Salivary Gland Diseases. 61
31735235 2020
13
Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling. 61
31339007 2020
14
Salivary Gland Disorders in Children and Adolescents: A 15-year Experience. 61
31929831 2020
15
Usefulness of ultrasound and fine needle aspiration cytology of major salivary gland lesions. 61
31732301 2020
16
[Nephropathy associated with hypocomplementemic urticarial vasculitis: A case report and literature review]. 61
31928955 2020
17
Drainless resection of the submandibular gland with facial vessel preservation: A comparative study. 61
31904533 2020
18
Retroauricular endoscope-assisted versus conventional submandibular gland excision for benign and malignant tumors. 61
31811452 2020
19
Disruption of tight junction structure contributes to secretory dysfunction in IgG4-related sialadenitis. 61
31865502 2019
20
RORγt antagonist improves Sjögren's syndrome-like sialadenitis through downregulation of CD25. 61
31837283 2019
21
[Application of ultrasonography scoring system in the assessment of IgG4-related sialadenitis]. 61
31848499 2019
22
Steroid Therapy and Steroid Response in Autoimmune Pancreatitis. 61
31905944 2019
23
Sonolocation during submandibular sialolithotomy. 61
30801712 2019
24
Arteriovenous vascular malformation of the submandibular gland masquerading as Küttner's tumour. 61
31888911 2019
25
Different clinical patterns of IgG4-RD patients with and without eosinophilia. 61
31712579 2019
26
Sclerosing sialadenitis of the submandibular gland is rarely an immunoglobulin G4-related disease in the Finnish population. 61
31680120 2019
27
Mitochondrial disorder mimicking rheumatoid disease. 61
30291434 2019
28
TNF-α Suppresses Autophagic Flux in Acinar Cells in IgG4-Related Sialadenitis. 61
31461632 2019
29
IgG4-Related Sialadenitis. 61
31760789 2019
30
[Sialolithiasis: Current Diagnostics and Therapy]. 61
31739357 2019
31
Sjögren syndrome and MIG. 61
31696913 2019
32
Removal of stones from the superficial lobe of the submandibular gland (SMG) via an intraoral endoscopy-assisted sialolithotomy. 61
30834990 2019
33
Hyperglycemia and Salivary Gland Dysfunction in the Non-obese Diabetic Mouse: Caveats for Preclinical Studies in Sjögren's Syndrome. 61
31784615 2019
34
Noninvasive treatment for chronic sialadenitis: Case report. 61
31632672 2019
35
Soft Palate Subacute Necrotising Sialadenitis: A Case Report. 61
31741964 2019
36
Sialadenitis in the Old-Old and Its Risk Factors. 61
31619068 2019
37
Encountering Chronic Sore Throat: How Challenging is it for the Otolaryngologists? 61
31741956 2019
38
Distinct Salivary Gland Features in Sjögren's Syndrome and Lupus Erythematosus Sialadenite. 61
31592858 2019
39
Etiological Evaluation of Patients with Lymphadenopathy by Clinical, Histopathological and Microbiological Assessment. 61
31599251 2019
40
Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy. 61
30996010 2019
41
Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. 61
31029591 2019
42
Autoimmune Pancreatitis and IgG4-Related Disease: The Storiform Discovery to Treatment. 61
31363956 2019
43
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. 61
30354922 2019
44
Transgenic rice seeds expressing altered peptide ligands against the M3 muscarinic acetylcholine receptor suppress experimental sialadenitis-like Sjögren's syndrome. 61
31490711 2019
45
Targeting gut microbiota and barrier function with prebiotics to alleviate autoimmune manifestations in NOD mice. 61
31139852 2019
46
Sialocele Following Traumatic Dental Procedure: A Case Report and Review of Dental Complications. 61
29112112 2019
47
Xanthogranulomatous Sialadenitis, an Uncommon Reactive Change is Often Associated with Warthin's Tumor. 61
31473936 2019
48
An unusual presentation of chronic sclerosing sialadenitis of submandibular gland (Kuttner's tumour). 61
31466959 2019
49
Successful treatment of tubulointerstitial nephritis in immunoglobulin G4-related disease with rituximab: A case report. 61
31531324 2019
50
Chronic sclerosing sialadenitis (Küttner's tumor) of the submandibular salivary gland: Our experience of one case report. 61
31428400 2019

Variations for Sialadenitis

Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TNFSF13B TNF TIMP3 OSM HSPG2 CD80
2
Show member pathways
13.62 TNFSF13B TNF OSM CD80 CD4 CD28
3
Show member pathways
13.62 TRIM21 TNFSF13B TNF OSM MMP2 ICOSLG
4
Show member pathways
13.25 TNFSF13B TNF TIMP3 OSM CD80 CD4
5
Show member pathways
13.18 TRIM21 TNFSF13B TNF OSM MMP2 HLA-DQB1
6
Show member pathways
13.02 TNFSF13B TNF TIMP3 OSM CD80 CD4
7
Show member pathways
12.76 TNFSF13B TNF ICOSLG HLA-DQB1 CD80 CD4
8
Show member pathways
12.59 TNF ICOSLG HLA-DQB1 CD80 CD4 CD28
9
Show member pathways
12.35 ICOSLG HLA-DQB1 CD80 CD4 CD28
10
Show member pathways
12.26 TNF CCR6 CCL23 CCL20
11 12.23 TNF TIMP3 MMP2 HSPG2
12
Show member pathways
12.13 ICOSLG HLA-DQB1 CD80 CD4 CD28
13
Show member pathways
11.97 TNF EBI3 CD80 CD4 CD28
14 11.9 TNF CD80 CD4 CD34 CD28
15
Show member pathways
11.88 TNF TIMP3 MMP2 HSPG2
16 11.87 TNF HLA-DQB1 CD4 CD34
17 11.75 TNF CD4 CD34 CCR6
18 11.68 TNF CD4 CD34
19 11.68 TNF CD80 CCL23 CCL20
20 11.66 HLA-DQB1 CD80 CD4 CD28
21 11.6 ICOSLG HLA-DQB1 CD80 CD4 CD34 CD28
22 11.55 ICOSLG CD80 CD28
23 11.51 CD80 CD4 CD34
24 11.46 TNF CD80 CCL20
25 11.43 CD80 CD4 CD28
26 11.07 TNFSF13B TNF HLA-DQB1 CD80 CD28 CCL20
27 10.83 TNFSF13B TNF TIMP3 OSM HSPG2 CD80

GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.18 TNFSF13B TNF MMP2 ICOSLG HTR3A HSPG2
2 extracellular space GO:0005615 9.91 TNFSF13B TNF TIMP3 OSM MMP2 HSPG2
3 cell surface GO:0009986 9.8 TNF CD80 CD4 CD34 CD28 CCR6
4 extracellular region GO:0005576 9.7 TNFSF13B TNF TIMP3 OSM MMP2 HSPG2
5 external side of plasma membrane GO:0009897 9.23 TNF ICOSLG EBI3 CD80 CD4 CD34
6 protein complex involved in cell adhesion GO:0098636 9.16 CD80 CD28

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 TNFSF13B ICOSLG HTR3A CD80 CD4 CD34
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 TNF CD4 CCL23 CCL20
3 positive regulation of protein kinase B signaling GO:0051897 9.8 TNF OSM CD80 CD28
4 T cell receptor signaling pathway GO:0050852 9.78 ICOSLG HLA-DQB1 CD4 CD28
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 OSM CD80 CD4
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.74 TNF OSM CD28
7 chemokine-mediated signaling pathway GO:0070098 9.73 CCR6 CCL23 CCL20
8 positive regulation of T cell proliferation GO:0042102 9.62 TNFSF13B CD80 CD4 CD28
9 T cell activation GO:0042110 9.61 ICOSLG CD4 CD28
10 humoral immune response GO:0006959 9.56 TNF EBI3 CD28 CCR6
11 positive regulation of alpha-beta T cell proliferation GO:0046641 9.55 EBI3 CD28
12 positive regulation of viral entry into host cell GO:0046598 9.54 TRIM21 CD4
13 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.54 CD80 CD4 CD28
14 T cell migration GO:0072678 9.51 CCR6 CCL20
15 T cell costimulation GO:0031295 9.46 TNFSF13B ICOSLG CD80 CD28
16 cytokine-mediated signaling pathway GO:0019221 9.43 TNF OSM MMP2 CD80 CD4 CCL20
17 thymocyte migration GO:0072679 9.4 CCR6 CCL20
18 immune response GO:0006955 9.32 TNFSF13B TNF OSM HLA-DQB1 CD80 CD4

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 TRIM21 TNFSF13B TNF TIMP3 SSB OSM
2 coreceptor activity GO:0015026 9.13 CD80 CD4 CD28
3 cytokine activity GO:0005125 9.1 TNFSF13B TNF OSM EBI3 CCL23 CCL20

Sources for Sialadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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