MCID: SLL001
MIFTS: 40

Sialolithiasis

Categories: Gastrointestinal diseases, Oral diseases, Endocrine diseases

Aliases & Classifications for Sialolithiasis

MalaCards integrated aliases for Sialolithiasis:

Name: Sialolithiasis 12 15 73
Stone of Salivary Gland or Duct 12
Salivary Gland Calculi 44
Salivary Gland Stone 12
Sialolith 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12905
ICD10 33 K11.5
ICD9CM 35 527.5
MeSH 44 D015494
NCIt 50 C34994
UMLS 73 C0036091

Summaries for Sialolithiasis

MalaCards based summary : Sialolithiasis, also known as stone of salivary gland or duct, is related to salivary duct calculi and breast medullary carcinoma. An important gene associated with Sialolithiasis is TRPC3 (Transient Receptor Potential Cation Channel Subfamily C Member 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and NF-kappaB Signaling. Affiliated tissues include salivary gland, and related phenotypes are Reduced mammosphere formation and cellular

Wikipedia : 76 Sialolithiasis (also termed salivary calculi, or salivary stones), is a condition where a calcified mass... more...

Related Diseases for Sialolithiasis

Diseases related to Sialolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 salivary duct calculi 11.0
2 breast medullary carcinoma 10.4 FASLG GZMB
3 lymphocytic gastritis 10.3 FASLG GZMB
4 sialadenitis 10.2
5 benign essential hypertension 10.2 ALB MGAM
6 b-cell expansion with nfkb and t-cell anergy 10.2 CD38 FASLG GZMB
7 tympanic membrane disease 10.1 NOTCH1 SPP1
8 uremia 9.9 AHSG ALB CASR SPP1
9 hemangioma 9.9
10 nephrolithiasis 9.9
11 cholelithiasis 9.9
12 primary hyperparathyroidism 9.9
13 hyperparathyroidism 9.9
14 cervicitis 9.9
15 calciphylaxis 9.8 ALB CASR
16 nephrogenic systemic fibrosis 9.8 CTGF SPP1 TGFB1
17 granulomatous gastritis 9.8 NOTCH1 PRTN3 SPP1
18 kidney hypertrophy 9.8 ALB CTGF TGFB1
19 iga glomerulonephritis 9.7 ALB CFP TGFB1
20 pilomatrixoma 9.7
21 down syndrome 9.7
22 cystic fibrosis 9.7
23 myeloma, multiple 9.7
24 aging 9.7
25 adenoiditis 9.7
26 adenoid cystic carcinoma 9.7
27 parotitis 9.7
28 salivary gland disease 9.7
29 epidermolysis bullosa 9.7
30 cavernous hemangioma 9.7
31 pancreatitis 9.7
32 acquired immunodeficiency syndrome 9.7
33 periodontitis 9.7
34 actinomycosis 9.7
35 neuropathy 9.7
36 odontoma 9.7
37 chronic pain 9.7
38 dysphagia 9.7
39 microvascular complications of diabetes 3 9.7 ALB CTGF TGFB1
40 retinal vascular disease 9.7 ALB CTGF HBA1 LRP5
41 urinary tract obstruction 9.7 ALB CTGF TGFB1
42 type 1 diabetes mellitus 11 9.7 HBA1 NOTCH1
43 aortic valve disease 1 9.6 NOTCH1 SPP1 TGFB1
44 urinary system disease 9.6 ALB CTGF HAVCR1 TGFB1
45 biliary atresia 9.4 ALB CTGF SPP1 TGFB1
46 pulmonary fibrosis, idiopathic 9.4 CTGF FASLG SPP1 TGFB1
47 glomerulonephritis 9.2 ALB CFP PRTN3 TGFB1
48 osteoporosis 8.9 AHSG ALB CASR LRP5 SPP1 TGFB1

Comorbidity relations with Sialolithiasis via Phenotypic Disease Network (PDN):


Hypertension, Essential Sialadenitis

Graphical network of the top 20 diseases related to Sialolithiasis:



Diseases related to Sialolithiasis

Symptoms & Phenotypes for Sialolithiasis

GenomeRNAi Phenotypes related to Sialolithiasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB FASLG LRP5 MGAM NOTCH1 PRTN3

MGI Mouse Phenotypes related to Sialolithiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 ALB CASR CD38 CTGF FASLG LRP5
2 homeostasis/metabolism MP:0005376 10.22 AHSG ALB CASR CD38 CFP CTGF
3 immune system MP:0005387 10.15 TIMP3 TRPC3 CASR CD38 CFP FASLG
4 hematopoietic system MP:0005397 10.13 PRTN3 SPP1 TGFB1 TIMP3 TRPC3 CASR
5 endocrine/exocrine gland MP:0005379 10.11 ALB CASR CD38 CTGF FASLG LRP5
6 liver/biliary system MP:0005370 9.92 ALB CTGF FASLG LRP5 NOTCH1 SPP1
7 muscle MP:0005369 9.8 AHSG ALB CASR NOTCH1 SPP1 TGFB1
8 renal/urinary system MP:0005367 9.7 ALB CASR FASLG NOTCH1 SPP1 TGFB1
9 skeleton MP:0005390 9.61 NOTCH1 SPP1 TGFB1 AHSG CASR CFP
10 vision/eye MP:0005391 9.23 TGFB1 TIMP3 TRPC3 CASR CTGF FASLG

Drugs & Therapeutics for Sialolithiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Association Between Nephrolithiasis and Periodontal Status Recruiting NCT03102086

Search NIH Clinical Center for Sialolithiasis

Cochrane evidence based reviews: salivary gland calculi

Genetic Tests for Sialolithiasis

Anatomical Context for Sialolithiasis

MalaCards organs/tissues related to Sialolithiasis:

41
Salivary Gland

Publications for Sialolithiasis

Articles related to Sialolithiasis:

(show top 50) (show all 276)
# Title Authors Year
1
Lack of evidence that nephrolithiasis increases the risk of sialolithiasis: A longitudinal follow-up study using a national sample cohort. ( 29698468 )
2018
2
Difficulties in Diagnosis of Sialolithiasis: A Case Series. ( 29563362 )
2018
3
Ultrasound elastography in diagnosis and follow-up for patients with sialolithiasis. ( 29668308 )
2018
4
Ultrasound Supplemented by Sialendoscopy: Diagnostic Value in Sialolithiasis. ( 29966489 )
2018
5
Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden. ( 29970034 )
2018
6
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
7
Sialendoscopy for sialolithiasis in children: 4-8 years follow up. ( 29373144 )
2018
8
Sialolithiasis of Right Submandibular Duct of Unusual Size. ( 29915487 )
2018
9
Cervical fistula caused by submandibular sialolithiasis. ( 29071060 )
2017
10
The Diagnostic Accuracy of Contrast-Enhanced CT of the Neck for the Investigation of Sialolithiasis. ( 28838906 )
2017
11
Sialolithiasis of an Accessory Parotid Gland Causing Mid-Cheek Pain. ( 28468191 )
2017
12
Comparison between Sialendoscopy and Conventional Methods in the Treatment of Sialolithiasis. ( 29386976 )
2017
13
Multimodal treatment in difficult sialolithiasis: Role of extracorporeal shock-wave lithotripsy and intraductal pneumatic lithotripsy. ( 29243260 )
2017
14
The Role of Fetuin-A and Electrolytes in the Etiology of Sialolithiasis. ( 28457217 )
2017
15
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
16
Pediatric sialolithiasis is not related to oral or oropharyngeal infection: A population-based case control study using the Korean National Health Insurance Database. ( 28483226 )
2017
17
Value of Sonography in the Diagnosis of Sialolithiasis: Comparison With the Reference Standard of Direct Stone Identification. ( 28556090 )
2017
18
Point-of-care Ultrasound Diagnosis of Acute Sialolithiasis with Sialadenitis. ( 29849382 )
2017
19
Sialolithiasis removal under general anesthesia: A descriptive retrospective study in the maxillofacial surgery department in Lille University Hospital. ( 29129709 )
2017
20
Idiopathic Sialolithiasis: Scalpel Versus Current Trends in Management. ( 28358758 )
2017
21
Treatment outcomes of sialendoscopy for submandibular gland sialolithiasis: The minor axis of the sialolith is a regulative factor for the removal of sialoliths in the hilum of the submandibular gland using sialendoscopy alone. ( 28935124 )
2017
22
Sialolithiasis Of Lower Lip - Histopathological Interpretation. ( 29076701 )
2017
23
Transoral submandibulotomy for deep hilar submandibular gland sialolithiasis. ( 28052363 )
2017
24
Sialolithiasis of an Accessory Parotid Gland Causing Mid-Cheek Pain. ( 28114210 )
2017
25
The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis. ( 28651858 )
2017
26
Accuracy of Ultrasonography and Computed Tomography in the Evaluation of Patients Undergoing Sialendoscopy for Sialolithiasis. ( 28457224 )
2017
27
Unilateral Submandibular Gland Atrophy and Sialolithiasis Diagnosed on 99mTc-MIBI SPECT/CT in a Patient With Primary Hyperparathyroidism. ( 29036000 )
2017
28
The value of the twinkling artefact for the diagnosis of sialolithiasis of the large salivary glands. ( 29248029 )
2017
29
Submandibular sialolithiasis with CT and scintigraphy: CT values and salivary gland excretion in the submandibular glands. ( 29279821 )
2017
30
A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa. ( 28050512 )
2016
31
Sialolithiasis is associated with nephrolithiasis: a case-control study. ( 26808906 )
2016
32
Does saliva composition affect the formation of sialolithiasis? ( 27974066 )
2016
33
Parotid cyst due to sialolithiasis masquerading as pilomatrixoma on FNA. ( 27943427 )
2016
34
A population-based study on the association between chronic periodontitis and sialolithiasis. ( 26808379 )
2016
35
Sialendoscopy for Sublingual Gland Sialolithiasis. ( 28056531 )
2016
36
A Hard Calculus: Submandibular Sialolithiasis. ( 27742262 )
2016
37
Incidence of sialolithiasis in Denmark: a nationwide population-based register study. ( 28005152 )
2016
38
Canine Sialolithiasis: Two Case Reports with Breed, Gender, and Age Distribution of 29 Cases (1964-2010). ( 26606211 )
2016
39
Possible Drug-Associated Sialolithiasis From the Bicarbonate Anhydrase Inhibitor Topiramate: A Case Report and Literature Review. ( 27292524 )
2016
40
Recurrent sialoliths after excision of the bilateral submandibular glands for sialolithiasis treatment: A case report. ( 26889264 )
2016
41
Sialolithiasis in an Accessory Submandibular Gland Identified by Magnetic Resonance Sialography. ( 26961009 )
2016
42
Rapid recurrent sialolithiasis: Altered stone composition and potential factors for recurrence. ( 27753112 )
2016
43
Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. ( 27701754 )
2016
44
Sialolithiasis of an accessory parotid gland: an unusual case. ( 26048098 )
2015
45
Clinicopathological aspects of 25 cases of sialolithiasis of minor salivary glands. ( 25945774 )
2015
46
Unusual form of sialolithiasis: case report with 3-dimensional imaging. ( 26530733 )
2015
47
Sialolithiasis in horses: A retrospective study of 25 cases (2002-2013). ( 26663918 )
2015
48
Does drinking water influence hospital-admitted sialolithiasis on an epidemiological level in Denmark? ( 25941183 )
2015
49
Endoscopic-assisted gland preserving therapy for the management of parotid gland sialolithiasis: Our preliminary experience. ( 26293189 )
2015
50
Combined approach sialendoscopy for management of submandibular gland sialolithiasis. ( 26052045 )
2015

Variations for Sialolithiasis

Expression for Sialolithiasis

Search GEO for disease gene expression data for Sialolithiasis.

Pathways for Sialolithiasis

GO Terms for Sialolithiasis

Cellular components related to Sialolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 CASR CD38 FASLG NOTCH1 TGFB1
2 extracellular region GO:0005576 9.73 AHSG ALB CFP CTGF FASLG HBA1
3 endoplasmic reticulum lumen GO:0005788 9.71 AHSG ALB CFP SPP1
4 blood microparticle GO:0072562 9.56 AHSG ALB HBA1 TGFB1
5 extracellular matrix GO:0031012 9.55 AHSG CFP PRTN3 TGFB1 TIMP3
6 platelet alpha granule lumen GO:0031093 9.54 AHSG ALB TGFB1
7 extracellular space GO:0005615 9.36 AHSG ALB CFP CTGF FASLG HBA1
8 extracellular exosome GO:0070062 10.02 AHSG ALB CD38 FASLG HBA1 MGAM

Biological processes related to Sialolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.83 CD38 LRP5 NOTCH1 SPP1 TGFB1
2 cellular calcium ion homeostasis GO:0006874 9.58 ATP2B3 CASR TGFB1
3 response to estradiol GO:0032355 9.54 CD38 CTGF TGFB1
4 response to organic substance GO:0010033 9.5 SPP1 TGFB1 TIMP3
5 ossification GO:0001503 9.43 AHSG CASR CTGF
6 platelet degranulation GO:0002576 9.26 AHSG ALB TGFB1 TIMP3
7 positive regulation of cell proliferation GO:0008284 9.17 CASR CTGF FASLG LRP5 NOTCH1 PRTN3
8 negative regulation of phagocytosis GO:0050765 9.16 PRTN3 TGFB1

Sources for Sialolithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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