MCID: SLL001
MIFTS: 31

Sialolithiasis

Categories: Endocrine diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Sialolithiasis

MalaCards integrated aliases for Sialolithiasis:

Name: Sialolithiasis 12 15 73
Stone of Salivary Gland or Duct 12
Salivary Gland Calculi 44
Salivary Gland Stone 12
Sialolith 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12905
ICD10 33 K11.5
ICD9CM 35 527.5
MeSH 44 D015494
SNOMED-CT 68 28826002
UMLS 73 C0036091

Summaries for Sialolithiasis

MalaCards based summary : Sialolithiasis, also known as stone of salivary gland or duct, is related to salivary duct calculi and sialadenitis. An important gene associated with Sialolithiasis is TRPC3 (Transient Receptor Potential Cation Channel Subfamily C Member 3), and among its related pathways/superpathways are Ion channel transport and Platelet homeostasis. Affiliated tissues include salivary gland.

Wikipedia : 76 Sialolithiasis (also termed salivary calculi, or salivary stones), is a condition where a calcified mass... more...

Related Diseases for Sialolithiasis

Diseases related to Sialolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 salivary duct calculi 11.1
2 sialadenitis 10.4
3 nephrolithiasis 10.1
4 adenoid cystic carcinoma 10.1
5 cholelithiasis 10.1
6 primary hyperparathyroidism 10.1
7 hyperparathyroidism 10.1
8 actinomycosis 10.1
9 lymphoma, mucosa-associated lymphoid type 10.0
10 endosteal hyperostosis, autosomal dominant 10.0
11 teeth, supernumerary 10.0
12 lymphoma 10.0
13 arteriovenous malformation 10.0
14 mucocele of salivary gland 10.0
15 granular cell tumor 10.0
16 pilomatrixoma 9.9
17 down syndrome 9.9
18 cystic fibrosis 9.9
19 myeloma, multiple 9.9
20 hemangioma 9.9
21 parotitis 9.9
22 epidermolysis bullosa 9.9
23 pancreatitis 9.9
24 acquired immunodeficiency syndrome 9.9
25 periodontitis 9.9
26 neuropathy 9.9
27 odontoma 9.9
28 pain - chronic 9.9
29 dysphagia 9.9

Comorbidity relations with Sialolithiasis via Phenotypic Disease Network (PDN):


Hypertension, Essential Sialadenitis

Graphical network of the top 20 diseases related to Sialolithiasis:



Diseases related to Sialolithiasis

Symptoms & Phenotypes for Sialolithiasis

Drugs & Therapeutics for Sialolithiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Association Between Nephrolithiasis and Periodontal Status Recruiting NCT03102086

Search NIH Clinical Center for Sialolithiasis

Cochrane evidence based reviews: salivary gland calculi

Genetic Tests for Sialolithiasis

Anatomical Context for Sialolithiasis

MalaCards organs/tissues related to Sialolithiasis:

41
Salivary Gland

Publications for Sialolithiasis

Articles related to Sialolithiasis:

(show top 50) (show all 294)
# Title Authors Year
1
Lack of evidence that nephrolithiasis increases the risk of sialolithiasis: A longitudinal follow-up study using a national sample cohort. ( 29698468 )
2018
2
Difficulties in Diagnosis of Sialolithiasis: A Case Series. ( 29563362 )
2018
3
Ultrasound elastography in diagnosis and follow-up for patients with sialolithiasis. ( 29668308 )
2018
4
Ultrasound Supplemented by Sialendoscopy: Diagnostic Value in Sialolithiasis. ( 29966489 )
2018
5
Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden. ( 29970034 )
2018
6
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
7
Sialendoscopy for sialolithiasis in children: 4-8 years follow up. ( 29373144 )
2018
8
Sialolithiasis of Right Submandibular Duct of Unusual Size. ( 29915487 )
2018
9
Adenoid Cystic Carcinoma With Sialolithiasis of the Left Submandibular Gland: A Case Report and Literature Review. ( 30482073 )
2018
10
The Positive Effect of Sialendoscopy with Irrigation Lavage for Sialadenitis without Sialolithiasis or Stenosis. ( 30110688 )
2018
11
One-year outcomes of sialendoscopic-assisted salivary duct surgery for sialadenitis without sialolithiasis. ( 30152080 )
2018
12
The value of the twinkling artefact for the diagnosis of sialolithiasis of the large salivary glands. ( 29248029 )
2018
13
Accessory submandibular duct sialolithiasis identified during sialendoscopy. ( 30036444 )
2018
14
One-Year symptom outcomes after sialolithiasis treatment with sialendoscopy-assisted salivary duct surgery. ( 30151855 )
2018
15
Intraductal Pneumatic Lithotripsy after Extended Transoral Duct Surgery in Submandibular Sialolithiasis. ( 30296893 )
2018
16
Cervical fistula caused by submandibular sialolithiasis. ( 29071060 )
2017
17
The Diagnostic Accuracy of Contrast-Enhanced CT of the Neck for the Investigation of Sialolithiasis. ( 28838906 )
2017
18
Sialolithiasis of an Accessory Parotid Gland Causing Mid-Cheek Pain. ( 28468191 )
2017
19
Comparison between Sialendoscopy and Conventional Methods in the Treatment of Sialolithiasis. ( 29386976 )
2017
20
Multimodal treatment in difficult sialolithiasis: Role of extracorporeal shock-wave lithotripsy and intraductal pneumatic lithotripsy. ( 29243260 )
2017
21
The Role of Fetuin-A and Electrolytes in the Etiology of Sialolithiasis. ( 28457217 )
2017
22
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
23
Pediatric sialolithiasis is not related to oral or oropharyngeal infection: A population-based case control study using the Korean National Health Insurance Database. ( 28483226 )
2017
24
Value of Sonography in the Diagnosis of Sialolithiasis: Comparison With the Reference Standard of Direct Stone Identification. ( 28556090 )
2017
25
Response to Letter to the Editor Regarding "Accuracy of Ultrasonography and Computed Tomography in the Evaluation of Patients Undergoing Sialendoscopy for Sialolithiasis". ( 29090648 )
2017
26
Point-of-care Ultrasound Diagnosis of Acute Sialolithiasis with Sialadenitis. ( 29849382 )
2017
27
Sialolithiasis removal under general anesthesia: A descriptive retrospective study in the maxillofacial surgery department in Lille University Hospital. ( 29129709 )
2017
28
Idiopathic Sialolithiasis: Scalpel Versus Current Trends in Management. ( 28358758 )
2017
29
Treatment outcomes of sialendoscopy for submandibular gland sialolithiasis: The minor axis of the sialolith is a regulative factor for the removal of sialoliths in the hilum of the submandibular gland using sialendoscopy alone. ( 28935124 )
2017
30
Sialolithiasis Of Lower Lip - Histopathological Interpretation. ( 29076701 )
2017
31
Transoral submandibulotomy for deep hilar submandibular gland sialolithiasis. ( 28052363 )
2017
32
Sialolithiasis of an Accessory Parotid Gland Causing Mid-Cheek Pain. ( 28114210 )
2017
33
Regarding "Accuracy of Ultrasonography and Computed Tomography in the Evaluation of Patients Undergoing Sialendoscopy for Sialolithiasis". ( 29090645 )
2017
34
The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis. ( 28651858 )
2017
35
Accuracy of Ultrasonography and Computed Tomography in the Evaluation of Patients Undergoing Sialendoscopy for Sialolithiasis. ( 28457224 )
2017
36
Unilateral Submandibular Gland Atrophy and Sialolithiasis Diagnosed on 99mTc-MIBI SPECT/CT in a Patient With Primary Hyperparathyroidism. ( 29036000 )
2017
37
Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. ( 27701754 )
2017
38
Rapid recurrent sialolithiasis: Altered stone composition and potential factors for recurrence. ( 27753112 )
2017
39
Submandibular sialolithiasis with CT and scintigraphy: CT values and salivary gland excretion in the submandibular glands. ( 29279821 )
2017
40
A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa. ( 28050512 )
2016
41
Sialolithiasis is associated with nephrolithiasis: a case-control study. ( 26808906 )
2016
42
Does saliva composition affect the formation of sialolithiasis? ( 27974066 )
2016
43
Parotid cyst due to sialolithiasis masquerading as pilomatrixoma on FNA. ( 27943427 )
2016
44
A population-based study on the association between chronic periodontitis and sialolithiasis. ( 26808379 )
2016
45
Sialendoscopy for Sublingual Gland Sialolithiasis. ( 28056531 )
2016
46
A Hard Calculus: Submandibular Sialolithiasis. ( 27742262 )
2016
47
Incidence of sialolithiasis in Denmark: a nationwide population-based register study. ( 28005152 )
2016
48
Canine Sialolithiasis: Two Case Reports with Breed, Gender, and Age Distribution of 29 Cases (1964-2010). ( 26606211 )
2016
49
Possible Drug-Associated Sialolithiasis From the Bicarbonate Anhydrase Inhibitor Topiramate: A Case Report and Literature Review. ( 27292524 )
2016
50
Recurrent sialoliths after excision of the bilateral submandibular glands for sialolithiasis treatment: A case report. ( 26889264 )
2016

Variations for Sialolithiasis

Expression for Sialolithiasis

Search GEO for disease gene expression data for Sialolithiasis.

Pathways for Sialolithiasis

Pathways related to Sialolithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.45 ATP2B3 TRPC3
2
Show member pathways
10.9 ATP2B3 TRPC3

GO Terms for Sialolithiasis

Biological processes related to Sialolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion transport GO:0006816 9.16 ATP2B3 TRPC3
2 calcium ion transmembrane transport GO:0070588 8.96 ATP2B3 TRPC3
3 regulation of cytosolic calcium ion concentration GO:0051480 8.62 ATP2B3 TRPC3

Sources for Sialolithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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