Sick Building Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sick Building Syndrome

MalaCards integrated aliases for Sick Building Syndrome:

Name: Sick Building Syndrome ¹¹ ⁴³ ¹⁴ ¹⁶ ⁷¹ ⁷⁵

Classifications:

MalaCards categories:
Anatomical: Immune diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:2710

MeSH ⁴³ D018877

SNOMED-CT ⁶⁸ 19076009

EFO ¹⁶ EFO_0007484

UMLS ⁷¹ C0037050

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Summaries for Sick Building Syndrome

Disease Ontology: ¹¹ An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

MalaCards based summary: Sick Building Syndrome is related to bronchitis and asthma. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Digestion and absorption. Affiliated tissues include eye, olfactory bulb and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and integument

Wikipedia: ⁷⁵ Sick building syndrome (SBS) is an unsubstantiated diagnosis where health problems are attributed to... more...

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Related Diseases for Sick Building Syndrome

Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)

#	Related Disease	Score	Top Affiliating Genes
1	bronchitis	30.0	VEGFA MMP9 IGHE
2	asthma	29.5	VEGFA TRPV1 POMC MMP9 LEP IGHE
3	migraine with or without aura 1	29.5	VEGFA TRPV1 POMC MMP9 LEP
4	ige responsiveness, atopic	10.6
5	rhinitis	10.5
6	chronic rhinitis	10.5
7	chronic fatigue syndrome	10.4
8	stachybotrys chartarum	10.4
9	multiple chemical sensitivity	10.4
10	headache	10.4
11	allergic rhinitis	10.3
12	legionnaire disease	10.3
13	aspergillosis	10.3
14	conjunctivitis	10.3
15	fibromyalgia	10.3
16	palmoplantar keratoderma, punctate type iii	10.2	POMC LEP
17	allergic disease	10.2
18	personality disorder	10.2
19	extrinsic allergic alveolitis	10.2
20	progressive non-infectious anterior vertebral fusion	10.2
21	atypical depressive disorder	10.2	POMC LEP
22	intracranial hypertension, idiopathic	10.2	POMC LEP
23	angiokeratoma circumscriptum	10.2	VEGFA MMP9
24	spinal cord injury	10.2	MMP9 LEP
25	hyperchlorhidrosis, isolated	10.2	TMEM11 POMC
26	punctate epithelial keratoconjunctivitis	10.2	VEGFA MMP9
27	pituitary apoplexy	10.2	POMC MMP9
28	cerebral artery occlusion	10.1	VEGFA MMP9
29	autoimmune disease	10.1
30	leptin deficiency or dysfunction	10.1
31	long covid	10.1
32	q fever	10.1
33	allergic conjunctivitis	10.1
34	conjunctival disease	10.1
35	keratoconjunctivitis	10.1
36	vernal keratoconjunctivitis	10.1
37	dysautonomia	10.1
38	atopic keratoconjunctivitis	10.1
39	central precocious puberty	10.1	POMC LEP
40	keratopathy	10.1	VEGFA MMP9
41	mild pre-eclampsia	10.1	VEGFA LEP
42	persistent fetal circulation syndrome	10.0	VEGFA POMC LEP
43	apnea, obstructive sleep	10.0	VEGFA POMC LEP
44	diabetic polyneuropathy	10.0	VEGFA TRPV1
45	decubitus ulcer	10.0	VEGFA MMP9
46	sleep apnea	10.0	VEGFA MMP9 LEP
47	animal phobia	10.0	AMY1C AMY1B
48	hypogonadism	10.0	POMC PNPLA6 LEP
49	aspiration pneumonia	10.0	TRPV1 POMC
50	corneal ulcer	10.0	VEGFA MMP9

Graphical network of the top 20 diseases related to Sick Building Syndrome:

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Symptoms & Phenotypes for Sick Building Syndrome

GenomeRNAi Phenotypes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

²⁵ (show all 14)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.03	POMC
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-104	10.03	LEP
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-112	10.03	LEP
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.03	LEP
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	10.03	LEP
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-184	10.03	POLR2B
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	10.03	AMY1A AMY1B AMY1C
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	10.03	LEP
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	10.03	LEP AMY1A AMY1B AMY1C
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-215	10.03	POLR2B
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-216	10.03	LEP
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	10.03	POMC
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-55	10.03	LEP
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-88	10.03	POMC AMY1A AMY1B AMY1C

MGI Mouse Phenotypes related to Sick Building Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.17	LEP MMP9 PNPLA6 POMC TMEM11 TRPV1

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Drugs & Therapeutics for Sick Building Syndrome

Search Clinical Trials, NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

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Genetic Tests for Sick Building Syndrome

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Anatomical Context for Sick Building Syndrome

Organs/tissues related to Sick Building Syndrome:

MalaCards : Eye, Olfactory Bulb, Bone Marrow, Skin, Whole Blood, Hypothalamus, Placenta

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Publications for Sick Building Syndrome

Articles related to Sick Building Syndrome:

(show top 50) (show all 573)

#	Title	Authors	PMID	Year
1	An assessment of volatile organic compounds pollutant emissions from wood materials: A review. ⁶²	Zhou X...Zhou H	36116618	2022
2	Autoimmune autonomic nervous system imbalance and conditions: Chronic fatigue syndrome, fibromyalgia, silicone breast implants, COVID and post-COVID syndrome, sick building syndrome, post-orthostatic tachycardia syndrome, autoimmune diseases and autoimmune/inflammatory syndrome induced by adjuvants. ⁶²	Malkova AM...Shoenfeld Y	36356798	2022
3	Autoimmune autonomic nervous system imbalance and conditions: Chronic fatigue syndrome, fibromyalgia, silicone breast implants, COVID and post-COVID syndrome, sick building syndrome, post-orthostatic tachycardia syndrome, autoimmune diseases and autoimmune/inflammatory syndrome induced by adjuvants. ⁶²	Malkova AM...Shoenfeld Y	36347462	2022
4	Effects of occupant behaviors on perceived dormitory air quality and sick building syndrome symptoms among female college students. ⁶²	Qiao R...Liu Y	36437662	2022
5	Thermal sensation, sick building syndrome symptoms, and physiological responses of occupants in environments with vertical air temperature differences. ⁶²	Wu Y...Liao C	36031205	2022
6	Validation of the Brazilian version of the questionnaire for detection of sick building syndrome. ⁶²	Silva JSE...Fernandes MA	35622373	2022
7	Respiratory Symptoms and Skin Sick Building Syndrome among Office Workers at University Hospital, Chiang Mai, Thailand: Associations with Indoor Air Quality, AIRMED Project. ⁶²	Surawattanasakul V...Muangkaew S	36078565	2022
8	Associations between indoor environment and lifestyles and sick building syndrome symptoms among adults in Taiyuan and Urumqi of China. ⁶²	Fu P...Yung KKL	35904392	2022
9	Prevalence of sick building syndrome in hospital staff and its relationship with indoor environmental quality. ⁶²	Akova I...Keklikci T	33322946	2022
10	Exposures, Symptoms and Risk Perception among Office Workers in Relation to Nanoparticles in the Work Environment. ⁶²	Orru H...Orru K	35627326	2022
11	Indoor air quality and sick building syndrome in a university setting: a case study in Greece. ⁶²	Tsantaki E...Benos A	32633551	2022
12	Assessment of sick building syndrome using visual analog scales. ⁶²	Dutheil F...Pereira B	35347792	2022
13	A high environmental composite quality factor score was associated with the risk of sick building syndrome among adults in northeast China. ⁶²	He Y...Ma Y	35045379	2022
14	Analysis of Cytokine Production Profiles of Local and Systemic Lymphocytes in Sick Building Syndrome Compared with Ocular Allergy. ⁶²	Izaki R...Uchio E	36034973	2022
15	Microbial Indoor Air Quality and Associated Factors in Jimma Town Prison Administration, Southwestern Ethiopia. ⁶²	Ahmednur M...Haile G	36003416	2022
16	The role of bio-pollutants in the indoor air quality of old museum buildings: artworks biodeterioration as preview of human diseases. ⁶²	Baldan M...Izzo FC	34757536	2021
17	Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice. ⁶²	Wakayama T...Kamijima M	34588381	2021
18	Classroom microbiome, functional pathways and sick-building syndrome (SBS) in urban and rural schools - Potential roles of indoor microbial amino acids and vitamin metabolites. ⁶²	Fu X...Sun Y	34328924	2021
19	Rapid and selective detection of macrocyclic trichothecene producing Stachybotrys chartarum strains by loop-mediated isothermal amplification (LAMP). ⁶²	Kock J...Niessen L	34129076	2021
20	Associations of indoor carbon dioxide concentrations, air temperature, and humidity with perceived air quality and sick building syndrome symptoms in Chinese homes. ⁶²	Hou J...Chen Q	33620091	2021
21	First Case of Invasive Stachybotrys Sinusitis. ⁶²	Semis M...Kalkum M	32155243	2021
22	Evaluation of the relationship between sick building syndrome complaints among hospital employees and indoor environmental quality. ⁶²	Sayan HE...Dulger S	33881009	2021
23	Effects of increased humidity on physiological responses, thermal comfort, perceived air quality, and Sick Building Syndrome symptoms at elevated indoor temperatures for subjects in a hot-humid climate. ⁶²	Zuo C...Liu W	32886843	2021
24	Sick building syndrome among healthcare workers and healthcare associates at observed general hospital in Slovenia. ⁶²	Kalender-Smajlovic S...Kukec A	33831284	2021
25	Investigating the Ventilation System of an Intensive Care Unit in the COVID-19 Crisis: A Study in a Hospital of Tehran, Iran. ⁶²	Moradpour Z...Zendehdel R	35382077	2021
26	Investigation and modeling of diurnal variation in suburban ambient formaldehyde concentration. ⁶²	Taguchi S...Kuramitz H	33179191	2021
27	The use of indoor plant as an alternative strategy to improve indoor air quality in Indonesia. ⁶²	Susanto AD...Wirawan A	32920542	2021
28	Quantification of seven microbial volatile organic compounds in human serum by solid-phase microextraction gas chromatography-tandem mass spectrometry. ⁶²	Wazeerud-Din IJ...De Jesus VR	33228985	2021
29	Occupational risks and their implications for the health of poultry farmers. ⁶²	Magri CA...Komiyama CM	34719452	2021
30	Low-grade systemic inflammation and the workplace. ⁶²	Viljoen M...Thomas Nee Negrao BL	34180461	2021
31	Association between indoor microbiome exposure and sick building syndrome (SBS) in junior high schools of Johor Bahru, Malaysia. ⁶²	Fu X...Sun Y	32890872	2021
32	The "Quarantine Dry Eye": The Lockdown for Coronavirus Disease 2019 and Its Implications for Ocular Surface Health. ⁶²	Napoli PE...Fossarello M	33907480	2021
33	Differentiation of S. chartarum (Ehrenb.) S. Hughes Chemotypes A and S via FT-IR Spectroscopy. ⁶²	Ekruth J...Schwaiger K	33037964	2020
34	Volatile Organic Compounds (VOCs) from Wood and Wood-Based Panels: Methods for Evaluation, Potential Health Risks, and Mitigation. ⁶²	Adamova T...Panek M	33036167	2020
35	Fungal Volatile Organic Compounds: More Than Just a Funky Smell? ⁶²	Inamdar AA...Bennett JW	32905756	2020
36	Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study. ⁶²	Ketema RM...Kishi R	32652952	2020
37	The Roles of Autoimmunity and Biotoxicosis in Sick Building Syndrome as a "Starting Point" for Irreversible Dampness and Mold Hypersensitivity Syndrome. ⁶²	Tuuminen T	32580407	2020
38	Differences in chemical composition of indoor air in rooms associated/not associated with building related symptoms. ⁶²	Veenaas C...Haglund P	32325564	2020
39	Association between human health and indoor air pollution in the Gulf Cooperation Council (GCC) countries: a review. ⁶²	Amoatey P...Kindzierski WB	32049656	2020
40	Mechanisms underlying nontoxic indoor air health problems: A review. ⁶²	Nordin S	32163882	2020
41	Working Conditions and Sick Building Syndrome among Health Care Workers in Vietnam. ⁶²	Hoang Quoc C...Nguyen Duc H	32455776	2020
42	Indoor Air Pollution, Related Human Diseases, and Recent Trends in the Control and Improvement of Indoor Air Quality. ⁶²	Tran VV...Lee YC	32340311	2020
43	Assessment of Indoor Air Quality and Users Perception of a Renovated Office Building in Manchester. ⁶²	Fahad Alomirah H...Moda HM	32192148	2020
44	Vacancy-Assisted Selective Detection of Low-ppb Formaldehyde in Two-Dimensional Layered SnS2. ⁶²	Hayashi K...Sato S	32058685	2020
45	Exposure to Wood Smoke and Associated Health Effects in Sub-Saharan Africa: A Systematic Review. ⁶²	Bede-Ojimadu O...Orisakwe OE	32211302	2020
46	Prevalence of sick building syndrome symptoms and its associated factors among bank employees in Pokhara Metropolitan, Nepal. ⁶²	Dhungana P...Chalise M	31868946	2020
47	Indoor Air Quality and Sick Building Syndrome: Are Green Buildings Better than Conventional Buildings? ⁶²	Gawande S...Bhadri A	32435112	2020
48	Moving to productivity: The benefits of healthy buildings. ⁶²	Palacios J...Kok N	32760082	2020
49	Using Ambient Scent to Enhance Well-Being in the Multisensory Built Environment. ⁶²	Spence C	33329267	2020
50	Prevalence and risk factors of pre-sick building syndrome: characteristics of indoor environmental and individual factors. ⁶²	Nakayama Y...Mori C	31847815	2019

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Genes for Sick Building Syndrome

Genes related to Sick Building Syndrome (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PNPLA6	Patatin Like Phospholipase Domain Containing 6	Protein Coding	12.32	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	POMC	Proopiomelanocortin	Protein Coding	11.42	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	LEP	Leptin	Protein Coding	10.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	8.24	GeneCards inferred via : Publications (show sections)
5	MMP9	Matrix Metallopeptidase 9	Protein Coding	8.05	GeneCards inferred via : Publications (show sections)
6	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	8.05	GeneCards inferred via : Publications (show sections)
7	TMEM11	Transmembrane Protein 11	Protein Coding	5.4	DISEASES inferred ¹⁴
8	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	4.94	DISEASES inferred ¹⁴
9	AMY1B	Amylase Alpha 1B	Protein Coding	4.89	DISEASES inferred ¹⁴
10	AMY1C	Amylase Alpha 1C	Protein Coding	4.89	DISEASES inferred ¹⁴
11	POLR2B	RNA Polymerase II Subunit B	Protein Coding	4.88	DISEASES inferred ¹⁴
12	AMY1A	Amylase Alpha 1A	Protein Coding	4.86	DISEASES inferred ¹⁴
13	TSR1	TSR1 Ribosome Maturation Factor	Protein Coding	4.86	DISEASES inferred ¹⁴

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Variations for Sick Building Syndrome

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Expression for Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

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Pathways for Sick Building Syndrome

Pathways related to Sick Building Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.37	VEGFA POMC MMP9
2	Digestion and absorption ⁶⁶ Show member pathways Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) ⁶⁶ Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) ⁶⁶ Digestion ⁶⁶ Digestion of dietary carbohydrate ⁶⁶ Digestion of dietary lipid ⁶⁶ Intestinal absorption ⁶⁶ Intestinal hexose absorption ⁶⁶ Intestinal lipid absorption ⁶⁶ Intestinal saccharidase deficiencies ⁶⁶	11.03	AMY1C AMY1B AMY1A
3	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	10.87	TRPV1 POMC
4	Prostaglandin signaling ⁷⁴	10.82	VEGFA MMP9
5	GPR143 in melanocytes and retinal pigment epithelium cells ⁷⁴	10.77	VEGFA POMC
6	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.56	POMC LEP
7	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.28	VEGFA POMC LEP

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GO Terms for Sick Building Syndrome

Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.53	VEGFA POMC MMP9 LEP IGHE AMY1C

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	metabolic process	GO:0008152	9.13	AMY1C AMY1B AMY1A
2	oligosaccharide metabolic process	GO:0009311	9.1	AMY1C AMY1B AMY1A

Molecular functions related to Sick Building Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chloride ion binding	GO:0031404	9.73	AMY1C AMY1B AMY1A
2	catalytic activity	GO:0003824	9.67	PNPLA6 AMY1C AMY1B AMY1A
3	hydrolase activity, acting on glycosyl bonds	GO:0016798	9.5	AMY1C AMY1B AMY1A
4	alpha-amylase activity	GO:0004556	9.43	AMY1C AMY1B AMY1A
5	cation binding	GO:0043169	9.33	AMY1C AMY1B AMY1A
6	amylase activity	GO:0016160	8.8	AMY1C AMY1B AMY1A

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Sources for Sick Building Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SCK001 MIFTS: 33	Sick Building Syndrome Categories: Immune diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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