MCID: SCK001
MIFTS: 33

Sick Building Syndrome

Categories: Immune diseases, Respiratory diseases
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Aliases & Classifications for Sick Building Syndrome

MalaCards integrated aliases for Sick Building Syndrome:

Name: Sick Building Syndrome 11 43 14 16 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:2710
MeSH 43 D018877
SNOMED-CT 68 19076009
UMLS 71 C0037050

Summaries for Sick Building Syndrome

Disease Ontology: 11 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

MalaCards based summary: Sick Building Syndrome is related to bronchitis and asthma. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Digestion and absorption. Affiliated tissues include eye, olfactory bulb and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and integument

Wikipedia: 75 Sick building syndrome (SBS) is an unsubstantiated diagnosis where health problems are attributed to... more...

Related Diseases for Sick Building Syndrome

Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 bronchitis 30.0 VEGFA MMP9 IGHE
2 asthma 29.5 VEGFA TRPV1 POMC MMP9 LEP IGHE
3 migraine with or without aura 1 29.5 VEGFA TRPV1 POMC MMP9 LEP
4 ige responsiveness, atopic 10.6
5 rhinitis 10.5
6 chronic rhinitis 10.5
7 chronic fatigue syndrome 10.4
8 stachybotrys chartarum 10.4
9 multiple chemical sensitivity 10.4
10 headache 10.4
11 allergic rhinitis 10.3
12 legionnaire disease 10.3
13 aspergillosis 10.3
14 conjunctivitis 10.3
15 fibromyalgia 10.3
16 palmoplantar keratoderma, punctate type iii 10.2 POMC LEP
17 allergic disease 10.2
18 personality disorder 10.2
19 extrinsic allergic alveolitis 10.2
20 progressive non-infectious anterior vertebral fusion 10.2
21 atypical depressive disorder 10.2 POMC LEP
22 intracranial hypertension, idiopathic 10.2 POMC LEP
23 angiokeratoma circumscriptum 10.2 VEGFA MMP9
24 spinal cord injury 10.2 MMP9 LEP
25 hyperchlorhidrosis, isolated 10.2 TMEM11 POMC
26 punctate epithelial keratoconjunctivitis 10.2 VEGFA MMP9
27 pituitary apoplexy 10.2 POMC MMP9
28 cerebral artery occlusion 10.1 VEGFA MMP9
29 autoimmune disease 10.1
30 leptin deficiency or dysfunction 10.1
31 long covid 10.1
32 q fever 10.1
33 allergic conjunctivitis 10.1
34 conjunctival disease 10.1
35 keratoconjunctivitis 10.1
36 vernal keratoconjunctivitis 10.1
37 dysautonomia 10.1
38 atopic keratoconjunctivitis 10.1
39 central precocious puberty 10.1 POMC LEP
40 keratopathy 10.1 VEGFA MMP9
41 mild pre-eclampsia 10.1 VEGFA LEP
42 persistent fetal circulation syndrome 10.0 VEGFA POMC LEP
43 apnea, obstructive sleep 10.0 VEGFA POMC LEP
44 diabetic polyneuropathy 10.0 VEGFA TRPV1
45 decubitus ulcer 10.0 VEGFA MMP9
46 sleep apnea 10.0 VEGFA MMP9 LEP
47 animal phobia 10.0 AMY1C AMY1B
48 hypogonadism 10.0 POMC PNPLA6 LEP
49 aspiration pneumonia 10.0 TRPV1 POMC
50 corneal ulcer 10.0 VEGFA MMP9

Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to Sick Building Syndrome

Symptoms & Phenotypes for Sick Building Syndrome

GenomeRNAi Phenotypes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.03 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-104 10.03 LEP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-112 10.03 LEP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.03 LEP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.03 LEP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-184 10.03 POLR2B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.03 AMY1A AMY1B AMY1C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.03 LEP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-213 10.03 LEP AMY1A AMY1B AMY1C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.03 POLR2B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-216 10.03 LEP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.03 POMC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-55 10.03 LEP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.03 POMC AMY1A AMY1B AMY1C

MGI Mouse Phenotypes related to Sick Building Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 LEP MMP9 PNPLA6 POMC TMEM11 TRPV1

Drugs & Therapeutics for Sick Building Syndrome

Search Clinical Trials, NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

Organs/tissues related to Sick Building Syndrome:

MalaCards : Eye, Olfactory Bulb, Bone Marrow, Skin, Whole Blood, Hypothalamus, Placenta

Publications for Sick Building Syndrome

Articles related to Sick Building Syndrome:

(show top 50) (show all 573)
# Title Authors PMID Year
1
An assessment of volatile organic compounds pollutant emissions from wood materials: A review. 62
36116618 2022
2
Autoimmune autonomic nervous system imbalance and conditions: Chronic fatigue syndrome, fibromyalgia, silicone breast implants, COVID and post-COVID syndrome, sick building syndrome, post-orthostatic tachycardia syndrome, autoimmune diseases and autoimmune/inflammatory syndrome induced by adjuvants. 62
36356798 2022
3
Autoimmune autonomic nervous system imbalance and conditions: Chronic fatigue syndrome, fibromyalgia, silicone breast implants, COVID and post-COVID syndrome, sick building syndrome, post-orthostatic tachycardia syndrome, autoimmune diseases and autoimmune/inflammatory syndrome induced by adjuvants. 62
36347462 2022
4
Effects of occupant behaviors on perceived dormitory air quality and sick building syndrome symptoms among female college students. 62
36437662 2022
5
Thermal sensation, sick building syndrome symptoms, and physiological responses of occupants in environments with vertical air temperature differences. 62
36031205 2022
6
Validation of the Brazilian version of the questionnaire for detection of sick building syndrome. 62
35622373 2022
7
Respiratory Symptoms and Skin Sick Building Syndrome among Office Workers at University Hospital, Chiang Mai, Thailand: Associations with Indoor Air Quality, AIRMED Project. 62
36078565 2022
8
Associations between indoor environment and lifestyles and sick building syndrome symptoms among adults in Taiyuan and Urumqi of China. 62
35904392 2022
9
Prevalence of sick building syndrome in hospital staff and its relationship with indoor environmental quality. 62
33322946 2022
10
Exposures, Symptoms and Risk Perception among Office Workers in Relation to Nanoparticles in the Work Environment. 62
35627326 2022
11
Indoor air quality and sick building syndrome in a university setting: a case study in Greece. 62
32633551 2022
12
Assessment of sick building syndrome using visual analog scales. 62
35347792 2022
13
A high environmental composite quality factor score was associated with the risk of sick building syndrome among adults in northeast China. 62
35045379 2022
14
Analysis of Cytokine Production Profiles of Local and Systemic Lymphocytes in Sick Building Syndrome Compared with Ocular Allergy. 62
36034973 2022
15
Microbial Indoor Air Quality and Associated Factors in Jimma Town Prison Administration, Southwestern Ethiopia. 62
36003416 2022
16
The role of bio-pollutants in the indoor air quality of old museum buildings: artworks biodeterioration as preview of human diseases. 62
34757536 2021
17
Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice. 62
34588381 2021
18
Classroom microbiome, functional pathways and sick-building syndrome (SBS) in urban and rural schools - Potential roles of indoor microbial amino acids and vitamin metabolites. 62
34328924 2021
19
Rapid and selective detection of macrocyclic trichothecene producing Stachybotrys chartarum strains by loop-mediated isothermal amplification (LAMP). 62
34129076 2021
20
Associations of indoor carbon dioxide concentrations, air temperature, and humidity with perceived air quality and sick building syndrome symptoms in Chinese homes. 62
33620091 2021
21
First Case of Invasive Stachybotrys Sinusitis. 62
32155243 2021
22
Evaluation of the relationship between sick building syndrome complaints among hospital employees and indoor environmental quality. 62
33881009 2021
23
Effects of increased humidity on physiological responses, thermal comfort, perceived air quality, and Sick Building Syndrome symptoms at elevated indoor temperatures for subjects in a hot-humid climate. 62
32886843 2021
24
Sick building syndrome among healthcare workers and healthcare associates at observed general hospital in Slovenia. 62
33831284 2021
25
Investigating the Ventilation System of an Intensive Care Unit in the COVID-19 Crisis: A Study in a Hospital of Tehran, Iran. 62
35382077 2021
26
Investigation and modeling of diurnal variation in suburban ambient formaldehyde concentration. 62
33179191 2021
27
The use of indoor plant as an alternative strategy to improve indoor air quality in Indonesia. 62
32920542 2021
28
Quantification of seven microbial volatile organic compounds in human serum by solid-phase microextraction gas chromatography-tandem mass spectrometry. 62
33228985 2021
29
Occupational risks and their implications for the health of poultry farmers. 62
34719452 2021
30
Low-grade systemic inflammation and the workplace. 62
34180461 2021
31
Association between indoor microbiome exposure and sick building syndrome (SBS) in junior high schools of Johor Bahru, Malaysia. 62
32890872 2021
32
The "Quarantine Dry Eye": The Lockdown for Coronavirus Disease 2019 and Its Implications for Ocular Surface Health. 62
33907480 2021
33
Differentiation of S. chartarum (Ehrenb.) S. Hughes Chemotypes A and S via FT-IR Spectroscopy. 62
33037964 2020
34
Volatile Organic Compounds (VOCs) from Wood and Wood-Based Panels: Methods for Evaluation, Potential Health Risks, and Mitigation. 62
33036167 2020
35
Fungal Volatile Organic Compounds: More Than Just a Funky Smell? 62
32905756 2020
36
Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study. 62
32652952 2020
37
The Roles of Autoimmunity and Biotoxicosis in Sick Building Syndrome as a "Starting Point" for Irreversible Dampness and Mold Hypersensitivity Syndrome. 62
32580407 2020
38
Differences in chemical composition of indoor air in rooms associated/not associated with building related symptoms. 62
32325564 2020
39
Association between human health and indoor air pollution in the Gulf Cooperation Council (GCC) countries: a review. 62
32049656 2020
40
Mechanisms underlying nontoxic indoor air health problems: A review. 62
32163882 2020
41
Working Conditions and Sick Building Syndrome among Health Care Workers in Vietnam. 62
32455776 2020
42
Indoor Air Pollution, Related Human Diseases, and Recent Trends in the Control and Improvement of Indoor Air Quality. 62
32340311 2020
43
Assessment of Indoor Air Quality and Users Perception of a Renovated Office Building in Manchester. 62
32192148 2020
44
Vacancy-Assisted Selective Detection of Low-ppb Formaldehyde in Two-Dimensional Layered SnS2. 62
32058685 2020
45
Exposure to Wood Smoke and Associated Health Effects in Sub-Saharan Africa: A Systematic Review. 62
32211302 2020
46
Prevalence of sick building syndrome symptoms and its associated factors among bank employees in Pokhara Metropolitan, Nepal. 62
31868946 2020
47
Indoor Air Quality and Sick Building Syndrome: Are Green Buildings Better than Conventional Buildings? 62
32435112 2020
48
Moving to productivity: The benefits of healthy buildings. 62
32760082 2020
49
Using Ambient Scent to Enhance Well-Being in the Multisensory Built Environment. 62
33329267 2020
50
Prevalence and risk factors of pre-sick building syndrome: characteristics of indoor environmental and individual factors. 62
31847815 2019

Variations for Sick Building Syndrome

Expression for Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for Sick Building Syndrome

GO Terms for Sick Building Syndrome

Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.53 VEGFA POMC MMP9 LEP IGHE AMY1C

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.13 AMY1C AMY1B AMY1A
2 oligosaccharide metabolic process GO:0009311 9.1 AMY1C AMY1B AMY1A

Molecular functions related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride ion binding GO:0031404 9.73 AMY1C AMY1B AMY1A
2 catalytic activity GO:0003824 9.67 PNPLA6 AMY1C AMY1B AMY1A
3 hydrolase activity, acting on glycosyl bonds GO:0016798 9.5 AMY1C AMY1B AMY1A
4 alpha-amylase activity GO:0004556 9.43 AMY1C AMY1B AMY1A
5 cation binding GO:0043169 9.33 AMY1C AMY1B AMY1A
6 amylase activity GO:0016160 8.8 AMY1C AMY1B AMY1A

Sources for Sick Building Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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