MCID: SCK001
MIFTS: 38

Sick Building Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Sick Building Syndrome

MalaCards integrated aliases for Sick Building Syndrome:

Name: Sick Building Syndrome 12 45 15 17 74 3

Classifications:



External Ids:

Disease Ontology 12 DOID:2710
MeSH 45 D018877
SNOMED-CT 69 19076009
UMLS 74 C0037050

Summaries for Sick Building Syndrome

CDC : 3 Indoor environmental quality (IEQ) refers to the quality of a building’s environment in relation to the health and wellbeing of those who occupy space within it. IEQ is determined by many factors, including lighting, air quality, and damp conditions. Workers are often concerned that they have symptoms or health conditions from exposures to contaminants in the buildings where they work. One reason for this concern is that their symptoms often get better when they are not in the building. While research has shown that some respiratory symptoms and illnesses can be associated with damp buildings, it is still unclear what measurements of indoor contaminants show that workers are at risk for disease. In most instances where a worker and his or her physician suspect that the building environment is causing a specific health condition, the information available from medical tests and tests of the environment is not sufficient to establish which contaminants are responsible. Despite uncertainty about what to measure and how to interpret what is measured, research shows that building-related symptoms are associated with building characteristics including dampness, cleanliness, and ventilation.

MalaCards based summary : Sick Building Syndrome is related to laurence-moon syndrome and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Bladder cancer. The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include eye, testes and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

Wikipedia : 77 Sick building syndrome (SBS) is a medical condition where people in a building suffer from symptoms of... more...

Related Diseases for Sick Building Syndrome

Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 laurence-moon syndrome 10.3 PNPLA6 POMC
2 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 LEP POMC
3 hypercholesterolemia, autosomal recessive 10.2 LEP POMC
4 pancreas disease 10.2 LEP POMC
5 amenorrhea 10.2 LEP POMC
6 pituitary tumors 10.1 POMC VEGFA
7 opiate dependence 10.1 POMC VEGFA
8 angiokeratoma circumscriptum 10.1 MMP9 VEGFA
9 adamantinous craniopharyngioma 10.1 MMP9 VEGFA
10 ischemic colitis 10.1 MMP9 VEGFA
11 odontogenic myxoma 10.1 MMP9 VEGFA
12 tuberculous meningitis 10.1 MMP9 VEGFA
13 rosacea 10.1 MMP9 VEGFA
14 eating disorder 10.1 LEP POMC
15 placental insufficiency 10.1 LEP VEGFA
16 arteriovenous malformation 10.1 MMP9 VEGFA
17 nasopharyngeal disease 10.1 MMP9 VEGFA
18 pharynx cancer 10.1 MMP9 VEGFA
19 multiple chemical sensitivity 10.1
20 chronic fatigue syndrome 10.1
21 adenomyosis 10.1 MMP9 VEGFA
22 diabetic neuropathy 10.1 LEP VEGFA
23 keratitis, hereditary 10.1 MMP9 VEGFA
24 drug dependence 10.1 CHRM2 POMC
25 grade iii astrocytoma 10.1 MMP9 VEGFA
26 overnutrition 10.0 LEP POMC
27 varicose veins 10.0 MMP9 VEGFA
28 male reproductive organ cancer 10.0 MMP9 VEGFA
29 brain edema 10.0 MMP9 VEGFA
30 stomach disease 10.0 MMP9 VEGFA
31 female reproductive system disease 9.9 MMP9 VEGFA
32 gonadal disease 9.9 POMC VEGFA
33 asthma 9.9
34 acute insulin response 9.9
35 anxiety 9.9
36 legionnaire disease 9.9
37 sinusitis 9.9
38 legionnaires' disease 9.9
39 legionellosis 9.9
40 rhinitis 9.9
41 neuropathy 9.9
42 stachybotrys chartarum 9.9
43 severe pre-eclampsia 9.9 LEP MMP9 VEGFA
44 arteries, anomalies of 9.9 LEP MMP9 VEGFA
45 respiratory system cancer 9.8 MMP9 VEGFA
46 glucose metabolism disease 9.8 LEP POMC

Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to Sick Building Syndrome

Symptoms & Phenotypes for Sick Building Syndrome

GenomeRNAi Phenotypes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.55 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.55 LRP6 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.55 LEP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.55 LEP LRP6 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.55 LRP6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.55 LRP6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.55 LRP6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.55 LEP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.55 POMC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.55 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.55 LRP6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.55 LRP6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.55 POMC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.55 POMC

MGI Mouse Phenotypes related to Sick Building Syndrome:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 CHRM2 ITM2B LEP LRP6 MMP9 PNPLA6
2 growth/size/body region MP:0005378 10.02 CHRM2 LEP LRP6 MMP9 PNPLA6 POMC
3 homeostasis/metabolism MP:0005376 10 CHRM2 LEP LRP6 MMP9 PNPLA6 POMC
4 cardiovascular system MP:0005385 9.99 CHRM2 LEP MMP9 PNPLA6 POMC VEGFA
5 integument MP:0010771 9.98 CHRM2 LEP LRP6 MMP9 PNPLA6 POMC
6 cellular MP:0005384 9.97 LEP LRP6 MMP9 PNPLA6 POMC VEGFA
7 nervous system MP:0003631 9.86 CHRM2 ITM2B LEP LRP6 MMP9 PNPLA6
8 liver/biliary system MP:0005370 9.77 CHRM2 LEP LRP6 POMC VEGFA
9 limbs/digits/tail MP:0005371 9.71 LEP LRP6 MMP9 VEGFA
10 renal/urinary system MP:0005367 9.63 CHRM2 LEP LRP6 MMP9 POMC VEGFA
11 neoplasm MP:0002006 9.62 LEP MMP9 POMC VEGFA
12 respiratory system MP:0005388 9.35 CHRM2 LEP LRP6 MMP9 VEGFA
13 vision/eye MP:0005391 9.02 CHRM2 LEP LRP6 MMP9 VEGFA

Drugs & Therapeutics for Sick Building Syndrome

Drugs for Sick Building Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Not Applicable 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Short-term Health Benefits of Using Fresh Air Filtration System in Classroom Completed NCT03788330 Not Applicable

Search NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

MalaCards organs/tissues related to Sick Building Syndrome:

42
Eye, Testes, Colon, Endothelial

Publications for Sick Building Syndrome

Articles related to Sick Building Syndrome:

(show top 50) (show all 219)
# Title Authors Year
1
Survey datasets on sick building syndrome: Causes and effects on selected public buildings in Lagos, Nigeria. ( 30246114 )
2018
2
Sick building syndrome and associated risk factors among the population of Gondar town, northwest Ethiopia. ( 30368236 )
2018
3
Relationship between sick building syndrome and indoor air quality among hospital staff. ( 30556534 )
2018
4
Personal, Psychosocial and Environmental Factors Related to Sick Building Syndrome in Official Employees of Taiwan. ( 29271881 )
2017
5
Clinical and allergological analysis of ocular manifestations of sick building syndrome. ( 28352150 )
2017
6
Endotoxin, ergosterol, muramic acid and fungal DNA in dust from schools in Johor Bahru, Malaysia--Associations with rhinitis and sick building syndrome (SBS) in junior high school students. ( 26745297 )
2016
7
Cognitive therapy in sick building syndrome: Myths, believes or evidence. ( 26654822 )
2016
8
Reply to Letter to the Editor: Cognitive therapy in Sick Building Syndrome: Myths, beliefs or evidence. ( 26684264 )
2016
9
Outdoor air pollution, meteorological conditions and indoor factors in dwellings in relation to sick building syndrome (SBS) among adults in China. ( 27101454 )
2016
10
Sick Building Syndrome: What It Is and Tips for Prevention. ( 30280861 )
2016
11
Sick Building Syndrome Among Junior High School Students in Japan in Relation to the Home and School Environment. ( 26383200 )
2015
12
Association of Sick Building Syndrome with Indoor Air Parameters. ( 26221153 )
2015
13
Assessment of sick building syndrome and its associating factors among nurses in the educational hospitals of Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ( 25716375 )
2015
14
Sick building syndrome (SBS) among office workers in a Malaysian university - Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment. ( 26225741 )
2015
15
Effect of Traffic Exposure on Sick Building Syndrome Symptoms among Parents/Grandparents of Preschool Children in Beijing, China. ( 26086248 )
2015
16
Social determinants of the sick building syndrome: exploring the interrelated effects of social position and psychosocial situation. ( 25424591 )
2014
17
Allostatic load model associated with indoor environmental quality and sick building syndrome among office workers. ( 24759685 )
2014
18
Effects of ventilation rate per person and per floor area on perceived air quality, sick building syndrome symptoms, and decision-making. ( 25142723 )
2014
19
A Longitudinal Study of Sick Building Syndrome (SBS) among Pupils in Relation to SO2, NO2, O3 and PM10 in Schools in China. ( 25398002 )
2014
20
Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese. ( 23418070 )
2013
21
Sick building syndrome (SBS) and sick house syndrome (SHS) in relation to psychosocial stress at work in the Swedish workforce. ( 23143072 )
2013
22
Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS). ( 23280302 )
2013
23
Odors and sensations of humidity and dryness in relation to sick building syndrome and home environment in Chongqing, China. ( 23991107 )
2013
24
Sick building syndrome by indoor air pollution in Dalian, China. ( 23579877 )
2013
25
Prevalence and risk factors of sick building syndrome among office workers. ( 23963091 )
2013
26
Office workers' sick building syndrome and indoor carbon dioxide concentrations. ( 22530709 )
2012
27
Dampness and moulds in workplace buildings: associations with incidence and remission of sick building syndrome (SBS) and biomarkers of inflammation in a 10 year follow-up study. ( 22634552 )
2012
28
The new model of sick building syndrome. ( 22350575 )
2012
29
A longitudinal study of aldehydes and volatile organic compounds associated with subjective symptoms related to sick building syndrome in new dwellings in Japan. ( 22265600 )
2012
30
Sick Building Syndrome and autoimmunity. ( 21300685 )
2011
31
The possible role of fungal contamination in sick building syndrome. ( 21196335 )
2011
32
The prevalence and incidence of sick building syndrome in Chinese pupils in relation to the school environment: a two-year follow-up study. ( 21615503 )
2011
33
Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan. ( 21198888 )
2011
34
Sick building syndrome in a general hospital and the risks for pregnant workers. ( 21458809 )
2011
35
The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. ( 21188456 )
2011
36
A longitudinal study of sick building syndrome among pupils in relation to microbial components in dust in schools in China. ( 21943723 )
2011
37
Relationship between indoor chemical concentrations and subjective symptoms associated with sick building syndrome in newly built houses in Japan. ( 19902238 )
2010
38
Sick building syndrome in relation to domestic exposure in Sweden--a cohort study from 1991 to 2001. ( 19850651 )
2010
39
Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese. ( 21787601 )
2010
40
Dampness, food habits, and sick building syndrome symptoms in elementary school pupils. ( 21432556 )
2010
41
An update on sick building syndrome. ( 19532093 )
2009
42
Association of neuroticism with sick building syndrome, quality of life and psychomotor performance. ( 19662780 )
2009
43
Quantitative relationship of sick building syndrome symptoms with ventilation rates. ( 19207289 )
2009
44
Sick Building Syndrome: is mould the cause? ( 19255924 )
2009
45
Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings. ( 19205722 )
2009
46
Molds, mycotoxins, and sick building syndrome. ( 19854820 )
2009
47
A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. ( 19608217 )
2009
48
Relation of dampness to sick building syndrome in Japanese public apartment houses. ( 19568865 )
2009
49
Indoor environment in dwellings, asthma, allergies, and sick building syndrome in the Swedish population: a longitudinal cohort study from 1989 to 1997. ( 19618200 )
2009
50
Do you have sick building syndrome? ( 18648309 )
2008

Variations for Sick Building Syndrome

Expression for Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for Sick Building Syndrome

GO Terms for Sick Building Syndrome

Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ITM2B LEP MMP9 POMC VEGFA
2 extracellular region GO:0005576 9.1 ITM2B LEP LRP6 MMP9 POMC VEGFA

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.43 MMP9 POMC VEGFA
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 LEP VEGFA
3 regulation of blood pressure GO:0008217 9.32 LEP POMC
4 positive regulation of p38MAPK cascade GO:1900745 9.16 LEP VEGFA
5 dopaminergic neuron differentiation GO:0071542 8.96 LRP6 VEGFA
6 macrophage differentiation GO:0030225 8.62 MMP9 VEGFA

Molecular functions related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 LEP LRP6 POMC

Sources for Sick Building Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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