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MCID: SCK001
MIFTS: 33

Sick Building Syndrome

Categories: Immune diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Sick Building Syndrome

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MalaCards integrated aliases for Sick Building Syndrome:

Name: Sick Building Syndrome 12 44 15 17 70

Classifications:

MalaCards categories:
Anatomical: Immune diseases Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2710
MeSH 44 D018877
SNOMED-CT 67 19076009
UMLS 70 C0037050
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Summaries for Sick Building Syndrome

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Disease Ontology : 12 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

MalaCards based summary : Sick Building Syndrome is related to ige responsiveness, atopic and rhinitis. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Galactose metabolism and Interleukin-4 and 13 signaling. Affiliated tissues include eye, skin and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Sick building syndrome (SBS) is a condition in which people in a building suffer from symptoms of... more...

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Related Diseases for Sick Building Syndrome

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Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 10.6
2 rhinitis 10.5
3 chronic fatigue syndrome 10.4
4 stachybotrys chartarum 10.4
5 headache 10.4
6 multiple chemical sensitivity 10.4
7 syndromic obesity 10.3 POMC LEP
8 allergic rhinitis 10.3
9 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 POMC LEP
10 atypical depressive disorder 10.2 POMC LEP
11 glucocorticoid deficiency 1 10.2 POMC LEP
12 diencephalic neoplasm 10.2 POMC LEP
13 conjunctivitis 10.2
14 extrinsic allergic alveolitis 10.2
15 angiokeratoma circumscriptum 10.2 VEGFA MMP9
16 odontogenic myxoma 10.2 VEGFA MMP9
17 intracranial hypertension, idiopathic 10.2 POMC LEP
18 myofascial pain syndrome 10.2 TRPV1 POMC
19 adamantinous craniopharyngioma 10.2 VEGFA MMP9
20 tuberculous meningitis 10.2 VEGFA MMP9
21 cough variant asthma 10.1 TRPV1 IGHE
22 gastroesophageal junction adenocarcinoma 10.1 VEGFA MMP9
23 migraine with or without aura 1 10.1
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
25 pollen allergy 10.1
26 legionellosis 10.1
27 q fever 10.1
28 allergic disease 10.1
29 fibromyalgia 10.1
30 persistent fetal circulation syndrome 10.1 VEGFA POMC LEP
31 eosinophilic meningitis 10.1 MMP9 IGHE
32 decubitus ulcer 10.1 VEGFA MMP9
33 severe pre-eclampsia 10.1 VEGFA MMP9 LEP
34 secondary progressive multiple sclerosis 10.1 VEGFA MMP9 LEP
35 ischemic colitis 10.0 VEGFA MMP9
36 specific developmental disorder 10.0 TRPV1 POMC LEP
37 diabetic neuropathy 10.0 VEGFA TRPV1 LEP
38 glucose metabolism disease 10.0 VEGFA POMC LEP
39 pulmonary hemosiderosis 10.0
40 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
41 short tarsus with absence of lower eyelashes 10.0
42 legionnaire disease 10.0
43 aspergillosis 10.0
44 pontiac fever 10.0
45 exanthem 10.0
46 tonsillitis 10.0
47 allergic conjunctivitis 10.0
48 hemosiderosis 10.0
49 pancytopenia 10.0
50 allergic bronchopulmonary aspergillosis 10.0

Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to Sick Building Syndrome
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Symptoms & Phenotypes for Sick Building Syndrome

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GenomeRNAi Phenotypes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 10.09 POMC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 10.09 AMY1A AMY1B AMY1C
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 10.09 POMC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.09 AMY1A AMY1B AMY1C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.09 POMC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 10.09 AMY1A AMY1B AMY1C
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 10.09 POMC
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 10.09 ERH
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 10.09 ERH
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 10.09 ERH
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10.09 POMC
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 10.09 ERH
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 10.09 AMY1A AMY1B AMY1C
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 10.09 POMC

MGI Mouse Phenotypes related to Sick Building Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 LEP MMP9 POMC TRPV1 VEGFA
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Drugs & Therapeutics for Sick Building Syndrome

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Search Clinical Trials , NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

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Genetic Tests for Sick Building Syndrome

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Anatomical Context for Sick Building Syndrome

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MalaCards organs/tissues related to Sick Building Syndrome:

40
Eye, Skin, Bone Marrow, Whole Blood, Placenta, Endothelial, Olfactory Bulb
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Publications for Sick Building Syndrome

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Articles related to Sick Building Syndrome:

(show top 50) (show all 550)
# Title Authors PMID Year
1
The use of indoor plant as an alternative strategy to improve indoor air quality in Indonesia. 61
32920542 2021
2
Effects of increased humidity on physiological responses, thermal comfort, perceived air quality, and Sick Building Syndrome symptoms at elevated indoor temperatures for subjects in a hot-humid climate. 61
32886843 2021
3
Investigation and modeling of diurnal variation in suburban ambient formaldehyde concentration. 61
33179191 2021
4
Quantification of seven microbial volatile organic compounds in human serum by solid-phase microextraction gas chromatography-tandem mass spectrometry. 61
33228985 2021
5
Associations of indoor carbon dioxide concentrations, air temperature, and humidity with perceived air quality and sick building syndrome symptoms in Chinese homes. 61
33620091 2021
6
Association between indoor microbiome exposure and sick building syndrome (SBS) in junior high schools of Johor Bahru, Malaysia. 61
32890872 2021
7
Prevalence of sick building syndrome in hospital staff and its relationship with indoor environmental quality. 61
33322946 2020
8
Differentiation of S. chartarum (Ehrenb.) S. Hughes Chemotypes A and S via FT-IR Spectroscopy. 61
33037964 2020
9
Volatile Organic Compounds (VOCs) from Wood and Wood-Based Panels: Methods for Evaluation, Potential Health Risks, and Mitigation. 61
33036167 2020
10
Fungal Volatile Organic Compounds: More Than Just a Funky Smell? 61
32905756 2020
11
Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study. 61
32652952 2020
12
Indoor air quality and sick building syndrome in a university setting: a case study in Greece. 61
32633551 2020
13
The Roles of Autoimmunity and Biotoxicosis in Sick Building Syndrome as a "Starting Point" for Irreversible Dampness and Mold Hypersensitivity Syndrome. 61
32580407 2020
14
Association between human health and indoor air pollution in the Gulf Cooperation Council (GCC) countries: a review. 61
32049656 2020
15
Differences in chemical composition of indoor air in rooms associated/not associated with building related symptoms. 61
32325564 2020
16
Working Conditions and Sick Building Syndrome among Health Care Workers in Vietnam. 61
32455776 2020
17
Mechanisms underlying nontoxic indoor air health problems: A review. 61
32163882 2020
18
Indoor Air Pollution, Related Human Diseases, and Recent Trends in the Control and Improvement of Indoor Air Quality. 61
32340311 2020
19
Vacancy-Assisted Selective Detection of Low-ppb Formaldehyde in Two-Dimensional Layered SnS2. 61
32058685 2020
20
Assessment of Indoor Air Quality and Users Perception of a Renovated Office Building in Manchester. 61
32192148 2020
21
First Case of Invasive Stachybotrys Sinusitis. 61
32155243 2020
22
Prevalence of sick building syndrome symptoms and its associated factors among bank employees in Pokhara Metropolitan, Nepal. 61
31868946 2020
23
Exposure to Wood Smoke and Associated Health Effects in Sub-Saharan Africa: A Systematic Review. 61
32211302 2020
24
Indoor Air Quality and Sick Building Syndrome: Are Green Buildings Better than Conventional Buildings? 61
32435112 2020
25
Using Ambient Scent to Enhance Well-Being in the Multisensory Built Environment. 61
33329267 2020
26
Moving to productivity: The benefits of healthy buildings. 61
32760082 2020
27
Prevalence and risk factors of pre-sick building syndrome: characteristics of indoor environmental and individual factors. 61
31847815 2019
28
Investigation of a Ventilation System for Energy Efficiency and Indoor Environmental Quality in a Renovated Historical Building: A Case Study. 61
31717831 2019
29
Association between Sick Building Syndrome and Indoor Environmental Quality in Slovenian Hospitals: A Cross-Sectional Study. 61
31484409 2019
30
Impacts of air conditioning on air quality in tiny homes in Hong Kong. 61
31154216 2019
31
Identification of MVOCs Produced by Coniophora puteana and Poria placenta Growing on WPC Boards by Using Subtraction Mass Spectra. 61
31337007 2019
32
Exploring the effects of ventilation practices in mitigating in-vehicle exposure to traffic-related air pollutants in China. 61
31030088 2019
33
Amine-Based Latex Coatings for Indoor Air CO2 Control in Commercial Buildings. 61
30973709 2019
34
Perception of indoor air quality (IAQ) by workers in underground shopping centers in relation to sick-building syndrome (SBS) and store type: a cross-sectional study in Korea. 61
31122231 2019
35
Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant. 61
30698348 2019
36
Prospective application of melanized fungi for the biofiltration of indoor air in closed bioregenerative systems. 61
30176406 2019
37
Relationship between sick building syndrome and indoor air quality among hospital staff. 61
30556534 2018
38
Sick building syndrome and associated risk factors among the population of Gondar town, northwest Ethiopia. 61
30368236 2018
39
Survey datasets on sick building syndrome: Causes and effects on selected public buildings in Lagos, Nigeria. 61
30246114 2018
40
Evaluation of indoor air quality and its symptoms in office building - A case study of Mashhad, Iran. 61
30105278 2018
41
Smartphone-Based Microfluidic Colorimetric Sensor for Gaseous Formaldehyde Determination with High Sensitivity and Selectivity. 61
30231467 2018
42
Exposure to volatile organic compounds and airway inflammation. 61
30086760 2018
43
Biomonitoring the indoor environment of agricultural buildings. 61
29936809 2018
44
Gender differences in public office workers' satisfaction, subjective symptoms and musculoskeletal complaints in workplace and office environments. 61
27976980 2018
45
Perspective: Scientific and ethical concerns pertaining to animal models of autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). 61
29526635 2018
46
The value of Autoimmune Syndrome Induced by Adjuvant (ASIA) - Shedding light on orphan diseases in autoimmunity. 61
29526630 2018
47
Formaldehyde Treatment Using Overexpressed Aldehyde Dehydrogenase 6 from Recombinant Saccharomyces cerevisiae. 61
29442983 2018
48
Prediction of Human Performance Using Electroencephalography under Different Indoor Room Temperatures. 61
29690601 2018
49
[New Scientific Evidence-based Public Health Guidelines and Practical Manual for Prevention of Sick House Syndrome]. 61
29848862 2018
50
[House Dust and Its Adverse Health Effects]. 61
29848863 2018
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Variations for Sick Building Syndrome

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Expression for Sick Building Syndrome

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Search GEO for disease gene expression data for Sick Building Syndrome.
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Pathways for Sick Building Syndrome

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Pathways related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Galactose metabolism 36 23
Show member pathways
 11.58 AMY1C AMY1B AMY1A
2
Interleukin-4 and 13 signaling 65
11.31 VEGFA POMC MMP9 IGHE
3
Carbohydrate digestion and absorption 36
11.1 AMY1C AMY1B AMY1A
4
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 10.81 VEGFA POMC LEP
5
Angiogenesis (WikiPathways) 1
10.78 VEGFA MMP9
6
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.67 POMC LEP
7
Digestion of dietary carbohydrate 65
9.75 AMY1C AMY1B AMY1A
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GO Terms for Sick Building Syndrome

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Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 VEGFA POMC MMP9 LEP AMY1C AMY1B

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.5 VEGFA MMP9 LEP
2 positive regulation of p38MAPK cascade GO:1900745 9.26 VEGFA LEP
3 cytokine-mediated signaling pathway GO:0019221 9.26 VEGFA POMC MMP9 IGHE
4 macrophage differentiation GO:0030225 9.16 VEGFA MMP9
5 oligosaccharide metabolic process GO:0009311 8.8 AMY1C AMY1B AMY1A

Molecular functions related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation binding GO:0043169 9.43 AMY1C AMY1B AMY1A
2 chloride ion binding GO:0031404 9.33 AMY1C AMY1B AMY1A
3 alpha-amylase activity (releasing maltohexaose) GO:0103025 9.13 AMY1C AMY1B AMY1A
4 alpha-amylase activity GO:0004556 8.8 AMY1C AMY1B AMY1A
Sources

Sources for Sick Building Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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