MCID: SCK001
MIFTS: 36

Sick Building Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Sick Building Syndrome

MalaCards integrated aliases for Sick Building Syndrome:

Name: Sick Building Syndrome 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2710
MeSH 43 D018877
SNOMED-CT 67 19076009
UMLS 71 C0037050

Summaries for Sick Building Syndrome

Disease Ontology : 12 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

MalaCards based summary : Sick Building Syndrome is related to bronchitis and irritable bowel syndrome. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Salivary secretion and Colorectal Cancer Metastasis. The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Sick building syndrome (SBS) is a medical condition where people in a building suffer from symptoms of... more...

Related Diseases for Sick Building Syndrome

Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 bronchitis 30.0 VEGFA MMP9 IGHE
2 irritable bowel syndrome 29.5 TRPV1 TRPA1 POMC
3 migraine with or without aura 1 29.2 TRPV1 TRPA1 POMC LEP
4 ige responsiveness, atopic 10.5
5 rhinitis 10.4
6 syndromic obesity 10.4 POMC LEP
7 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.4 POMC LEP
8 hypothalamic disease 10.4 POMC LEP
9 atypical depressive disorder 10.3 POMC LEP
10 chronic fatigue syndrome 10.3
11 stachybotrys chartarum 10.3
12 odontogenic myxoma 10.3 VEGFA MMP9
13 angiokeratoma circumscriptum 10.3 VEGFA MMP9
14 aromatase excess syndrome 10.3 POMC LEP
15 multiple chemical sensitivity 10.3
16 intracranial hypertension, idiopathic 10.3 POMC LEP
17 adamantinous craniopharyngioma 10.3 VEGFA MMP9
18 tuberculous meningitis 10.3 VEGFA MMP9
19 gastroesophageal junction adenocarcinoma 10.3 VEGFA MMP9
20 mild pre-eclampsia 10.2 VEGFA LEP
21 eosinophilic meningitis 10.2 MMP9 IGHE
22 allergic rhinitis 10.2
23 persistent fetal circulation syndrome 10.2 VEGFA POMC LEP
24 allergic hypersensitivity disease 10.1
25 extrinsic allergic alveolitis 10.1
26 headache 10.1
27 severe pre-eclampsia 10.1 VEGFA MMP9 LEP
28 secondary progressive multiple sclerosis 10.1 VEGFA MMP9 LEP
29 myofascial pain syndrome 10.1 TRPV1 POMC
30 cough variant asthma 10.1 TRPV1 IGHE
31 skin tag 10.1 TRPA1 LEP
32 decubitus ulcer 10.1 VEGFA MMP9
33 pollen allergy 10.1
34 legionellosis 10.1
35 q fever 10.1
36 conjunctivitis 10.1
37 fibromyalgia 10.1
38 glucose metabolism disease 10.0 VEGFA POMC LEP
39 ischemic colitis 9.9 VEGFA MMP9
40 atherosclerosis susceptibility 9.9 VEGFA MMP9 LEP
41 photokeratitis 9.9 TRPV1 TRPA1
42 acquired metabolic disease 9.9 VEGFA POMC LEP
43 arteries, anomalies of 9.9 VEGFA MMP9 LEP
44 dentin sensitivity 9.9 TRPV1 TRPA1
45 pulmonary hemosiderosis 9.9
46 short tarsus with absence of lower eyelashes 9.9
47 asthma 9.9
48 legionnaire disease 9.9
49 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
50 aspergillosis 9.9

Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to Sick Building Syndrome

Symptoms & Phenotypes for Sick Building Syndrome

GenomeRNAi Phenotypes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.98 LEP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.98 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.98 LRP6
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.98 AMY1A AMY1B AMY1C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.98 LRP6
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.98 AMY1A AMY1B AMY1C
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.98 LRP6
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.98 AMY1A AMY1B AMY1C LEP LRP6
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.98 LEP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.98 LEP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.98 AMY1A AMY1B AMY1C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.83 POMC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.83 LRP6 POMC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 AMY1A AMY1B AMY1C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.83 LRP6 POMC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.83 LRP6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.83 AMY1A AMY1B AMY1C LRP6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.83 LRP6
19 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.83 POMC
20 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.83 POMC
21 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.83 LRP6
22 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.83 LRP6
23 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.83 AMY1A AMY1B AMY1C POMC
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.83 POMC

MGI Mouse Phenotypes related to Sick Building Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ITM2B LEP LRP6 MMP9 PNPLA6 POMC
2 integument MP:0010771 9.86 LEP LRP6 MMP9 PNPLA6 POMC TRPA1
3 nervous system MP:0003631 9.81 ITM2B LEP LRP6 MMP9 PNPLA6 POMC
4 no phenotypic analysis MP:0003012 9.43 ITM2B LRP6 POMC TRPA1 TRPV1 VEGFA
5 renal/urinary system MP:0005367 9.1 LEP LRP6 MMP9 POMC TRPV1 VEGFA

Drugs & Therapeutics for Sick Building Syndrome

Drugs for Sick Building Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Fresh Air Filtration System on Indoor Air Quality and Children's Health in Shanghai Schools Completed NCT03788330

Search NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

MalaCards organs/tissues related to Sick Building Syndrome:

40
Eye, Skin, Testes, Lung, Bone Marrow, Bone, Whole Blood

Publications for Sick Building Syndrome

Articles related to Sick Building Syndrome:

(show top 50) (show all 521)
# Title Authors PMID Year
1
Prevalence and risk factors of pre-sick building syndrome: characteristics of indoor environmental and individual factors. 61
31847815 2019
2
Investigation of a Ventilation System for Energy Efficiency and Indoor Environmental Quality in a Renovated Historical Building: A Case Study. 61
31717831 2019
3
Impacts of air conditioning on air quality in tiny homes in Hong Kong. 61
31154216 2019
4
Association between Sick Building Syndrome and Indoor Environmental Quality in Slovenian Hospitals: A Cross-Sectional Study. 61
31484409 2019
5
Identification of MVOCs Produced by Coniophora puteana and Poria placenta Growing on WPC Boards by Using Subtraction Mass Spectra. 61
31337007 2019
6
Exploring the effects of ventilation practices in mitigating in-vehicle exposure to traffic-related air pollutants in China. 61
31030088 2019
7
Amine-Based Latex Coatings for Indoor Air CO2 Control in Commercial Buildings. 61
30973709 2019
8
Perception of indoor air quality (IAQ) by workers in underground shopping centers in relation to sick-building syndrome (SBS) and store type: a cross-sectional study in Korea. 61
31122231 2019
9
Prospective application of melanized fungi for the biofiltration of indoor air in closed bioregenerative systems. 61
30176406 2019
10
Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant. 61
30698348 2019
11
Relationship between sick building syndrome and indoor air quality among hospital staff. 61
30556534 2018
12
Survey datasets on sick building syndrome: Causes and effects on selected public buildings in Lagos, Nigeria. 61
30246114 2018
13
Sick building syndrome and associated risk factors among the population of Gondar town, northwest Ethiopia. 61
30368236 2018
14
Evaluation of indoor air quality and its symptoms in office building - A case study of Mashhad, Iran. 61
30105278 2018
15
Smartphone-Based Microfluidic Colorimetric Sensor for Gaseous Formaldehyde Determination with High Sensitivity and Selectivity. 61
30231467 2018
16
Exposure to volatile organic compounds and airway inflammation. 61
30086760 2018
17
Biomonitoring the indoor environment of agricultural buildings. 61
29936809 2018
18
Gender differences in public office workers' satisfaction, subjective symptoms and musculoskeletal complaints in workplace and office environments. 61
27976980 2018
19
Perspective: Scientific and ethical concerns pertaining to animal models of autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). 61
29526635 2018
20
The value of Autoimmune Syndrome Induced by Adjuvant (ASIA) - Shedding light on orphan diseases in autoimmunity. 61
29526630 2018
21
Formaldehyde Treatment Using Overexpressed Aldehyde Dehydrogenase 6 from Recombinant Saccharomyces cerevisiae. 61
29442983 2018
22
Prediction of Human Performance Using Electroencephalography under Different Indoor Room Temperatures. 61
29690601 2018
23
[New Scientific Evidence-based Public Health Guidelines and Practical Manual for Prevention of Sick House Syndrome]. 61
29848862 2018
24
[House Dust and Its Adverse Health Effects]. 61
29848863 2018
25
The cough frequency among call center workers: "call center cough". 61
29631528 2017
26
Personal, Psychosocial and Environmental Factors Related to Sick Building Syndrome in Official Employees of Taiwan. 61
29271881 2017
27
Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA). 61
28888842 2017
28
SBS symptoms in relation to dampness and ventilation in inspected single-family houses in Sweden. 61
28624972 2017
29
Assessment and biomonitoring indoor environment of buildings. 61
28868901 2017
30
Efficacy of a titanium dioxide nanoparticles - based indoor anti-odor product as assessed by electronic nose and gaschromatography-mass spectrometry. 61
28336003 2017
31
Reflections on the history of indoor air science, focusing on the last 50 years. 61
28107552 2017
32
Mold and Human Health: a Reality Check. 61
28299723 2017
33
[Environmental medical syndromes]. 61
28447135 2017
34
Effects of chronic exposure to Formaldehyde on micronucleus rate of bone marrow cells in male mice. 61
28585597 2017
35
Nanoparticular surface-bound PCBs, PCDDs, and PCDFs-a novel class of potentially higher toxic POPs. 61
26939687 2017
36
Thermal comfort, perceived air quality, and cognitive performance when personally controlled air movement is used by tropically acclimatized persons. 61
27754563 2017
37
Validation and uncertainty estimation of UPLC-PDA method for the analysis of polycyclic aromatic hydrocarbons in concrete. 61
27940116 2017
38
The correlation of Acanthamoeba from the ventilation system with other environmental parameters in commercial buildings as possible indicator for indoor air quality. 61
27476379 2017
39
Monitoring Indoor Air Quality for Enhanced Occupational Health. 61
28000117 2017
40
Factors Contributing to the Self-Reported Prevalence of Multiple Chemical Sensitivity in Public Facility Workers and the General Population of Korea. 61
29249738 2017
41
Clinical and allergological analysis of ocular manifestations of sick building syndrome. 61
28352150 2017
42
Clinical Diagnosis of the Dampness and Mold Hypersensitivity Syndrome: Review of the Literature and Suggested Diagnostic Criteria. 61
28848553 2017
43
Sick Building Syndrome: What It Is and Tips for Prevention. 61
30280861 2016
44
Outdoor air pollution, meteorological conditions and indoor factors in dwellings in relation to sick building syndrome (SBS) among adults in China. 61
27101454 2016
45
Levels of formaldehyde vapor released from embalmed cadavers in each dissection stage. 61
27151243 2016
46
Subchronic inhalation exposure to 2-ethyl-1-hexanol impairs the mouse olfactory bulb via injury and subsequent repair of the nasal olfactory epithelium. 61
27055686 2016
47
The effect of increased classroom ventilation rate indicated by reduced CO2 concentration on the performance of schoolwork by children. 61
25866236 2016
48
Endotoxin, ergosterol, muramic acid and fungal DNA in dust from schools in Johor Bahru, Malaysia--Associations with rhinitis and sick building syndrome (SBS) in junior high school students. 61
26745297 2016
49
Cognitive therapy in sick building syndrome: Myths, believes or evidence. 61
26654822 2016
50
[Health risks associated with the environmental presence of toxigenic moulds]. 61
30351746 2016

Variations for Sick Building Syndrome

Expression for Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for Sick Building Syndrome

GO Terms for Sick Building Syndrome

Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 VEGFA POMC MMP9 LEP ITM2B AMY1C
2 extracellular region GO:0005576 9.32 VEGFA POMC MMP9 LRP6 LEP ITM2B

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 VEGFA POMC MMP9 IGHE
2 dopaminergic neuron differentiation GO:0071542 9.37 VEGFA LRP6
3 response to pain GO:0048265 9.32 TRPV1 TRPA1
4 macrophage differentiation GO:0030225 9.26 VEGFA MMP9
5 detection of chemical stimulus involved in sensory perception of pain GO:0050968 8.96 TRPV1 TRPA1
6 thermoception GO:0050955 8.62 TRPV1 TRPA1

Molecular functions related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 9.43 AMY1C AMY1B AMY1A
2 cation binding GO:0043169 9.33 AMY1C AMY1B AMY1A
3 calcium-release channel activity GO:0015278 9.32 TRPV1 TRPA1
4 alpha-amylase activity (releasing maltohexaose) GO:0103025 9.13 AMY1C AMY1B AMY1A
5 alpha-amylase activity GO:0004556 8.8 AMY1C AMY1B AMY1A

Sources for Sick Building Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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