SND
MCID: SCK002
MIFTS: 54

Sick Sinus Syndrome (SND)

Categories: Cardiovascular diseases, Genetic diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Sick Sinus Syndrome

MalaCards integrated aliases for Sick Sinus Syndrome:

Name: Sick Sinus Syndrome 12 25 37 29 55 6 44 15 73
Sinus Node Disease 25 29 6
Sinus Node Dysfunction 25 73
Sinus Node Infection 12
Sss 25
Snd 25

Classifications:



External Ids:

Disease Ontology 12 DOID:13884
ICD10 33 I49.5
MeSH 44 D012804
NCIt 50 C62244
SNOMED-CT 68 36083008
KEGG 37 H00729

Summaries for Sick Sinus Syndrome

Genetics Home Reference : 25 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards based summary : Sick Sinus Syndrome, also known as sinus node disease, is related to familial sick sinus syndrome and syncope. An important gene associated with Sick Sinus Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and DREAM Repression and Dynorphin Expression. The drugs Propafenone and Sotalol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Sick sinus syndrome (SSS), also called sinus dysfunction, or sinoatrial node disease ("SND"), is a group... more...

Related Diseases for Sick Sinus Syndrome

Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 2 Sick Sinus Syndrome 1
Sick Sinus Syndrome 3 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 familial sick sinus syndrome 34.0 HCN4 MYH6 SCN5A
2 syncope 30.8 SCN5A TTN
3 atrioventricular block 30.7 HCN4 LMNA SCN5A
4 atrial fibrillation 30.5 F2 HCN4 SCN5A SHOX2
5 atrial standstill 1 30.0 LMNA MYH6 SCN5A TTN
6 brugada syndrome 29.9 CACNA1C HCN4 RANGRF SCN5A SNTA1
7 cardiac conduction defect 29.9 LMNA SCN5A
8 long qt syndrome 29.7 CACNA1C HCN4 SCN5A SNTA1
9 right bundle branch block 29.7 CACNA1C HCN4 SCN5A
10 sinoatrial node disease 29.6 HCN4 MYH6 SCN5A SHOX2
11 holt-oram syndrome 29.6 MYH6 SHOX2
12 hypertrophic cardiomyopathy 29.2 CACNA1C LMNA MYH6 SCN5A TTN
13 left ventricular noncompaction 29.2 HCN4 LMNA MYH6 SCN5A SNTA1 TTN
14 dilated cardiomyopathy 29.1 CACNA1C LMNA MYH6 SCN5A TTN
15 heart disease 28.9 CACNA1C F2 HCN4 LMNA MYH6 SCN5A
16 sick sinus syndrome 1 12.7
17 sick sinus syndrome 3 12.6
18 sick sinus syndrome 2 12.6
19 isolated levocardia 11.5
20 chronic atrial and intestinal dysrhythmia 11.4
21 stiff skin syndrome 11.4
22 sinus node disease and myopia 11.2
23 cardiac arrhythmia, ankyrin-b-related 11.2
24 language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia 11.2
25 hypoparathyroidism-retardation-dysmorphism syndrome 11.0
26 hypoparathyroidism-intellectual disability-dysmorphism syndrome 11.0
27 subclavian steal syndrome 11.0
28 amyloidosis 10.3
29 lymphoma 10.2
30 third-degree atrioventricular block 10.1 HCN4 SCN5A
31 long qt syndrome 12 10.1 SCN5A SNTA1
32 endometrial cancer 10.1
33 second-degree atrioventricular block 10.1 HCN4 LMNA
34 catecholaminergic polymorphic ventricular tachycardia 10.1
35 lymphosarcoma 10.1
36 dextrocardia 10.1
37 long qt syndrome 9 10.1 HCN4 SCN5A SNTA1
38 popliteal pterygium syndrome 10.1
39 fibromyalgia 10.1
40 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.0 LMNA TTN
41 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.0 LMNA TTN
42 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.0 LMNA TTN
43 jervell and lange-nielsen syndrome 1 10.0 CACNA1C SCN5A
44 familial isolated dilated cardiomyopathy 10.0 MYH6 SCN5A TTN
45 arteries, anomalies of 10.0
46 myeloma, multiple 10.0
47 myocardial infarction 10.0
48 coronary artery anomaly 10.0
49 pericarditis 10.0
50 atrial heart septal defect 10.0

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to Sick Sinus Syndrome

Symptoms & Phenotypes for Sick Sinus Syndrome

GenomeRNAi Phenotypes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.7 SHOX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.7 SCN5A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.7 F2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.7 SHOX2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.7 F2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.7 SCN5A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.7 F2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.7 SCN5A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.7 F2 SCN5A SHOX2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.7 SHOX2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.7 F2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.7 SHOX2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.7 F2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.7 SCN5A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.7 SCN5A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.7 SHOX2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 SCN5A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 SCN5A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 F2 SCN5A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.7 SHOX2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.7 SCN5A

MGI Mouse Phenotypes related to Sick Sinus Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 CACNA1C F2 LMNA MYH6 SCN5A SGO1
2 cardiovascular system MP:0005385 9.92 CACNA1C F2 HCN4 LMNA MYH6 SCN5A
3 homeostasis/metabolism MP:0005376 9.86 CACNA1C F2 LMNA MYH6 SGO1 SHOX2
4 mortality/aging MP:0010768 9.81 CACNA1C F2 HCN4 LMNA MYH6 SCN5A
5 muscle MP:0005369 9.5 CACNA1C HCN4 LMNA MYH6 SCN5A SNTA1
6 nervous system MP:0003631 9.17 CACNA1C F2 HCN4 LMNA SCN5A SHOX2

Drugs & Therapeutics for Sick Sinus Syndrome

Drugs for Sick Sinus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propafenone Approved Phase 4 54063-53-5 4932
2
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
3
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
4
Atenolol Approved Phase 4 29122-68-7 2249
5
Nebivolol Approved, Investigational Phase 4 99200-09-6, 152520-56-4, 118457-14-0 71301
6
Ethanol Approved Phase 4 64-17-5 702
7
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
8 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
10 Sodium Channel Blockers Phase 4
11 Adrenergic Agents Phase 4
12 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
13 Diuretics, Potassium Sparing Phase 4
14 Autonomic Agents Phase 4
15 Anti-Arrhythmia Agents Phase 4,Not Applicable
16 Adrenergic beta-Antagonists Phase 4
17 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Potassium Channel Blockers Phase 4
20 Neurotransmitter Agents Phase 4
21 Cytochrome P-450 CYP3A Inhibitors Phase 4
22 Vasodilator Agents Phase 4
23 Sympatholytics Phase 4
24 Adrenergic Antagonists Phase 4
25 Antihypertensive Agents Phase 4,Not Applicable
26 Adrenergic beta-Agonists Phase 4
27 Adrenergic beta-1 Receptor Antagonists Phase 4
28 Adrenergic Agonists Phase 4
29
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
30
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
31
Ofloxacin Approved Phase 3 82419-36-1 4583
32
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 10909430 439542
33
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
34 Topoisomerase Inhibitors Phase 3
35 Polymyxins Phase 3
36 Anti-Bacterial Agents Phase 3
37 Anti-Infective Agents, Local Phase 3
38 Renal Agents Phase 3
39 Anti-Infective Agents Phase 3
40 Clindamycin palmitate Phase 3
41 Clindamycin phosphate Phase 3
42 Polymyxin B Phase 3
43 Antibiotics, Antitubercular Phase 3
44 Anti-Infective Agents, Urinary Phase 3
45 Antitubercular Agents Phase 3
46
Angiotensin II Approved, Investigational ,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
47
Losartan Approved Not Applicable 114798-26-4 3961
48 tannic acid Approved Not Applicable
49
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
50
Digoxin Approved 20830-75-5 30322 2724385

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
2 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
3 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
4 Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation Unknown status NCT02145546 Phase 4 Amiodarone;Propafenone;Sotalol
5 Syncope: Pacing or Recording in the Later Years Unknown status NCT01423994 Phase 4
6 The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker Completed NCT03245996 Phase 4 Atenolol Pill;Nebivolol Pill;Ivabradine Pill
7 Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation Completed NCT00161538 Phase 4
8 Austria Study - Analysis of Difference Between Active and Passive Fixation Leads Completed NCT00180557 Phase 4
9 Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease Completed NCT01170611 Phase 4
10 Falls and Cardiovascular Events in Pacemaker Patients Completed NCT01037426 Phase 4
11 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
12 Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease Recruiting NCT03566667 Phase 4 Metoprolol;Standard care
13 Virtual Clinic Pacemaker Follow-up Terminated NCT00475124 Phase 4
14 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation Completed NCT02317068 Phase 3
15 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
16 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
17 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
18 Second Study on Cardio-neuromodulation in Humans Unknown status NCT02954666 Phase 2
19 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
20 The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome Unknown status NCT01310920
21 The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome Unknown status NCT00647257 Not Applicable Losartan;Placebo
22 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241 Not Applicable
23 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
24 Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position Unknown status NCT01647490 Not Applicable
25 Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance Unknown status NCT01798043 Not Applicable
26 Minimizing Ventricular Pacing Unknown status NCT01611389 Not Applicable
27 Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study Completed NCT01528657 Not Applicable
28 Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI) Completed NCT00785564
29 Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot Completed NCT02198781
30 Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858
31 The Atrial High Rate Episodes in Pacemaker Patients Completed NCT00627328
32 Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class Completed NCT00292539
33 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum Completed NCT01609738
34 SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction Completed NCT00284830 Not Applicable
35 Brady MX a Quality Improvement Study Completed NCT02976181
36 Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) Completed NCT00664807
37 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed NCT00478933 Not Applicable
38 To Pace or Not to Pace in Sinus Node Disease Completed NCT02485093 Not Applicable
39 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction Completed NCT02027909
40 Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing Completed NCT01803217 Not Applicable
41 Right Ventricular Outflow Tract Study Completed NCT01294839 Not Applicable
42 Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PATCH-ED) Completed NCT02683174 Not Applicable
43 Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode Completed NCT02586480
44 Ingenio Device Algorithm Study Completed NCT01441583 Not Applicable
45 IES-ACap: Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm. Completed NCT00832260
46 PANORAMA Observational Study Completed NCT00382525
47 Real Life Automatic Atrial Capture Device Control Completed NCT02400983
48 Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome. Recruiting NCT02034526 Not Applicable
49 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Recruiting NCT02314897 Not Applicable
50 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717 Not Applicable

Search NIH Clinical Center for Sick Sinus Syndrome

Cochrane evidence based reviews: sick sinus syndrome

Genetic Tests for Sick Sinus Syndrome

Genetic tests related to Sick Sinus Syndrome:

# Genetic test Affiliating Genes
1 Sick Sinus Syndrome 29
2 Sinus Node Disease 29

Anatomical Context for Sick Sinus Syndrome

MalaCards organs/tissues related to Sick Sinus Syndrome:

41
Heart, Testes, Endothelial, Brain, Atrioventricular Node, Lung, Skin

Publications for Sick Sinus Syndrome

Articles related to Sick Sinus Syndrome:

(show top 50) (show all 692)
# Title Authors Year
1
TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling. ( 29511803 )
2018
2
Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome. ( 29967700 )
2018
3
MECP2 mutation in a boy with severe apnea and sick sinus syndrome. ( 29631775 )
2018
4
Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations. ( 29568937 )
2018
5
Sick Sinus Syndrome. ( 29784479 )
2018
6
Heart rate reduction decreases central blood pressure in sick sinus syndrome patients with a permanent cardiac pacemaker. ( 29581554 )
2018
7
Catheter ablation of paroxysmal atrial fibrillation in patients with sick sinus syndrome. ( 30178186 )
2018
8
Sex-Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome. ( 30371189 )
2018
9
Sick sinus syndrome associated with anti-programmed cell death-1. ( 30012209 )
2018
10
Sick sinus syndrome in cardiac noncompaction. ( 30112287 )
2018
11
Sick Sinus Syndrome and Takotsubo Cardiomyopathy. ( 30210876 )
2018
12
TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome. ( 30259525 )
2018
13
Safety and efficacy of AAIR pacing in selected patients with sick sinus syndrome. ( 30334983 )
2018
14
Sick Sinus Syndrome After the Maze Procedure Performed Concomitantly With Mitral Valve Surgery. ( 30371317 )
2018
15
Sick Sinus Syndrome Observed in a Patient with Cholinesterase Deficiency. ( 30449782 )
2018
16
Clinically oriented device programming in bradycardia patients: part 1 (sinus node disease). Proposals from AIAC (Italian Association of Arrhythmology and Cardiac Pacing). ( 29470250 )
2018
17
Isolated Persistent Left Superior Vena Cava, Sick Sinus Syndrome, and Challenging Pacemaker Implantation. ( 28912977 )
2017
18
A Functional Assay for Sick Sinus Syndrome Genetic Variants. ( 28803248 )
2017
19
Long term effects of cilostazol in a dog with sick sinus syndrome. ( 28458273 )
2017
20
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
21
Persistent Sick Sinus Syndrome in Scrub Typhus. ( 28500798 )
2017
22
Value of Combining Left Atrial Diameter and Amino-terminal Pro-brain Natriuretic Peptide to the CHA2DS2-VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation. ( 28776540 )
2017
23
Transient sick sinus syndrome with complete atrioventricular block associated with ergonovine intake: A case report. ( 29095320 )
2017
24
Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction. ( 28104484 )
2017
25
Hyperthyroidism and sick sinus syndrome, a rare but challenging association: A study of three cases. ( 28891553 )
2017
26
Seizure Triggered by Sick Sinus Syndrome. ( 29103011 )
2017
27
Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. ( 28674041 )
2017
28
Eleven-year trends of inpatient pacemaker implantation in patients diagnosed with sick sinus syndrome. ( 28471545 )
2017
29
An unexpected presentation of sick sinus syndrome: Isolated ventricular asystole. ( 28460803 )
2017
30
Sick sinus syndrome. ( 28644224 )
2017
31
Congenital sick sinus syndrome: Prenatal diagnosis and postnatal follow-up. ( 28805625 )
2017
32
Clinical phenotype of HCN4-related sick sinus syndrome. ( 28213054 )
2017
33
Tying Ourselves in Knots to Avoid Ventricular Pacing in Sick Sinus Syndrome: Does it Matter? ( 29759605 )
2017
34
The proportion of asymptomatic recurrence after catheter ablation of atrial fibrillation in patients with a pacemaker for sick sinus syndrome. ( 29192587 )
2017
35
Implantation of VVI pacemaker in a patient with dextrocardia, persistent left superior vena cava, and sick sinus syndrome: A case report. ( 28151908 )
2017
36
Complex regional pain syndrome induced by pacemaker implantation for sick sinus syndrome. ( 29255517 )
2017
37
Corrigendum to "Falls and Fractures in the Elderly with Sinus Node Disease: The Impact of Pacemaker Implantation". ( 29158941 )
2017
38
Atrioventricular Interval Extension Is Highly Efficient in Preventing Unnecessary Right Ventricular Pacing in Sinus Node Disease: A Randomized Cross-Over Study Versus Dual- to Atrial Single-Chamber Mode Switch. ( 29759604 )
2017
39
Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. ( 27182706 )
2016
40
Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome. ( 26798387 )
2016
41
Transforming Growth Factor-I^1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level. ( 27380173 )
2016
42
Autosomal recessive atrial disease presenting with sick sinus syndrome (SSS), right atrial fibrosis and biatrial dilatation: Clinical impact of genetic diagnosis. ( 26828384 )
2016
43
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. ( 26831068 )
2016
44
Single lead atrial vs. dual chamber pacing in sick sinus syndrome: extended register-based follow-up in the DANPACE trial. ( 28039212 )
2016
45
SEVERE AMIODARONE-INDUCED BRADICARDIA CONCEALES SICK SINUS SYNDROME: CASE REPORT. ( 27125081 )
2016
46
Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014). ( 27286907 )
2016
47
Safety and efficiency of ventricular pacing prevention with an AAI-DDD changeover mode in patients with sinus node disease or atrioventricular block: impact on battery longevity-a sub-study of the ANSWER trial. ( 26612882 )
2016
48
Beneficial effects of losartan for prevention of paroxysmal atrial fibrillation in patients with sick sinus syndrome: analysis with memory function of pacemaker. ( 25787020 )
2016
49
Bradycardia-dependent rise in the atrial capture threshold early after cardiac pacemaker implantation in patients with sick sinus syndrome. ( 28491626 )
2016
50
Red blood cell distribution width and atrial fibrillation in patients with sick sinus syndrome. ( 26321105 )
2015

Variations for Sick Sinus Syndrome

ClinVar genetic disease variations for Sick Sinus Syndrome:

6 (show top 50) (show all 225)
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.5350G> A (p.Glu1784Lys) single nucleotide variant Pathogenic rs137854601 GRCh37 Chromosome 3, 38592513: 38592513
2 SCN5A NM_198056.2(SCN5A): c.5350G> A (p.Glu1784Lys) single nucleotide variant Pathogenic rs137854601 GRCh38 Chromosome 3, 38551022: 38551022
3 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh37 Chromosome 3, 38620907: 38620907
4 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh38 Chromosome 3, 38579416: 38579416
5 SCN5A NM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu) single nucleotide variant Pathogenic rs28937319 GRCh37 Chromosome 3, 38603976: 38603976
6 SCN5A NM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu) single nucleotide variant Pathogenic rs28937319 GRCh38 Chromosome 3, 38562485: 38562485
7 SCN5A NM_198056.2(SCN5A): c.1673A> G (p.His558Arg) single nucleotide variant Benign/Likely benign rs1805124 GRCh37 Chromosome 3, 38645420: 38645420
8 SCN5A NM_198056.2(SCN5A): c.1673A> G (p.His558Arg) single nucleotide variant Benign/Likely benign rs1805124 GRCh38 Chromosome 3, 38603929: 38603929
9 SCN5A NM_000335.4(SCN5A): c.2436+12G> A single nucleotide variant Conflicting interpretations of pathogenicity rs41312419 GRCh37 Chromosome 3, 38628879: 38628879
10 SCN5A NM_000335.4(SCN5A): c.2436+12G> A single nucleotide variant Conflicting interpretations of pathogenicity rs41312419 GRCh38 Chromosome 3, 38587388: 38587388
11 SCN5A NM_198056.2(SCN5A): c.4437+13C> T single nucleotide variant Conflicting interpretations of pathogenicity rs148598985 GRCh37 Chromosome 3, 38597919: 38597919
12 SCN5A NM_198056.2(SCN5A): c.4437+13C> T single nucleotide variant Conflicting interpretations of pathogenicity rs148598985 GRCh38 Chromosome 3, 38556428: 38556428
13 SCN5A NM_198056.2(SCN5A): c.100C> T (p.Arg34Cys) single nucleotide variant Benign/Likely benign rs6791924 GRCh37 Chromosome 3, 38674699: 38674699
14 SCN5A NM_198056.2(SCN5A): c.100C> T (p.Arg34Cys) single nucleotide variant Benign/Likely benign rs6791924 GRCh38 Chromosome 3, 38633208: 38633208
15 SCN5A NM_198056.2(SCN5A): c.1141-3C> A single nucleotide variant Benign/Likely benign rs41312433 GRCh37 Chromosome 3, 38647642: 38647642
16 SCN5A NM_198056.2(SCN5A): c.1141-3C> A single nucleotide variant Benign/Likely benign rs41312433 GRCh38 Chromosome 3, 38606151: 38606151
17 SCN5A NM_198056.2(SCN5A): c.1302C> T (p.Phe434=) single nucleotide variant Benign/Likely benign rs41313699 GRCh37 Chromosome 3, 38647478: 38647478
18 SCN5A NM_198056.2(SCN5A): c.1302C> T (p.Phe434=) single nucleotide variant Benign/Likely benign rs41313699 GRCh38 Chromosome 3, 38605987: 38605987
19 SCN5A NM_198056.2(SCN5A): c.1681C> T (p.Leu561=) single nucleotide variant Conflicting interpretations of pathogenicity rs45522138 GRCh37 Chromosome 3, 38645412: 38645412
20 SCN5A NM_198056.2(SCN5A): c.1681C> T (p.Leu561=) single nucleotide variant Conflicting interpretations of pathogenicity rs45522138 GRCh38 Chromosome 3, 38603921: 38603921
21 SCN5A NM_198056.2(SCN5A): c.2788-6C> T single nucleotide variant Benign/Likely benign rs41260344 GRCh37 Chromosome 3, 38622868: 38622868
22 SCN5A NM_198056.2(SCN5A): c.2788-6C> T single nucleotide variant Benign/Likely benign rs41260344 GRCh38 Chromosome 3, 38581377: 38581377
23 SCN5A NM_198056.2(SCN5A): c.3183A> G (p.Glu1061=) single nucleotide variant Benign/Likely benign rs7430407 GRCh37 Chromosome 3, 38622467: 38622467
24 SCN5A NM_198056.2(SCN5A): c.3183A> G (p.Glu1061=) single nucleotide variant Benign/Likely benign rs7430407 GRCh38 Chromosome 3, 38580976: 38580976
25 SCN5A NM_198056.2(SCN5A): c.3363G> A (p.Ala1121=) single nucleotide variant Conflicting interpretations of pathogenicity rs9858585 GRCh37 Chromosome 3, 38620852: 38620852
26 SCN5A NM_198056.2(SCN5A): c.3363G> A (p.Ala1121=) single nucleotide variant Conflicting interpretations of pathogenicity rs9858585 GRCh38 Chromosome 3, 38579361: 38579361
27 SCN5A NM_000335.4(SCN5A): c.4845C> T (p.Phe1615=) single nucleotide variant Benign/Likely benign rs41315495 GRCh37 Chromosome 3, 38593015: 38593015
28 SCN5A NM_000335.4(SCN5A): c.4845C> T (p.Phe1615=) single nucleotide variant Benign/Likely benign rs41315495 GRCh38 Chromosome 3, 38551524: 38551524
29 SCN5A NM_198056.2(SCN5A): c.5457T> C (p.Asp1819=) single nucleotide variant Benign/Likely benign rs1805126 GRCh37 Chromosome 3, 38592406: 38592406
30 SCN5A NM_198056.2(SCN5A): c.5457T> C (p.Asp1819=) single nucleotide variant Benign/Likely benign rs1805126 GRCh38 Chromosome 3, 38550915: 38550915
31 SCN5A NM_000335.4(SCN5A): c.5841C> T (p.Ile1947=) single nucleotide variant Benign/Likely benign rs13324293 GRCh37 Chromosome 3, 38592019: 38592019
32 SCN5A NM_000335.4(SCN5A): c.5841C> T (p.Ile1947=) single nucleotide variant Benign/Likely benign rs13324293 GRCh38 Chromosome 3, 38550528: 38550528
33 SCN5A NM_198056.2(SCN5A): c.87A> G (p.Ala29=) single nucleotide variant Benign/Likely benign rs6599230 GRCh37 Chromosome 3, 38674712: 38674712
34 SCN5A NM_198056.2(SCN5A): c.87A> G (p.Ala29=) single nucleotide variant Benign/Likely benign rs6599230 GRCh38 Chromosome 3, 38633221: 38633221
35 SCN5A NM_198056.2(SCN5A): c.1715C> A (p.Ala572Asp) single nucleotide variant Benign/Likely benign rs36210423 GRCh37 Chromosome 3, 38645378: 38645378
36 SCN5A NM_198056.2(SCN5A): c.1715C> A (p.Ala572Asp) single nucleotide variant Benign/Likely benign rs36210423 GRCh38 Chromosome 3, 38603887: 38603887
37 SCN5A NM_198056.2(SCN5A): c.21T> A (p.Pro7=) single nucleotide variant Conflicting interpretations of pathogenicity rs587781157 GRCh37 Chromosome 3, 38674778: 38674778
38 SCN5A NM_198056.2(SCN5A): c.21T> A (p.Pro7=) single nucleotide variant Conflicting interpretations of pathogenicity rs587781157 GRCh38 Chromosome 3, 38633287: 38633287
39 SCN5A NM_198056.2(SCN5A): c.1044C> T (p.Pro348=) single nucleotide variant Conflicting interpretations of pathogenicity rs370346797 GRCh37 Chromosome 3, 38648256: 38648256
40 SCN5A NM_198056.2(SCN5A): c.1044C> T (p.Pro348=) single nucleotide variant Conflicting interpretations of pathogenicity rs370346797 GRCh38 Chromosome 3, 38606765: 38606765
41 SCN5A NM_198056.2(SCN5A): c.1743G> A (p.Ser581=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313687 GRCh37 Chromosome 3, 38645350: 38645350
42 SCN5A NM_198056.2(SCN5A): c.1743G> A (p.Ser581=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313687 GRCh38 Chromosome 3, 38603859: 38603859
43 SCN5A NM_198056.2(SCN5A): c.2437-5C> A single nucleotide variant Conflicting interpretations of pathogenicity rs72549411 GRCh37 Chromosome 3, 38627537: 38627537
44 SCN5A NM_198056.2(SCN5A): c.2437-5C> A single nucleotide variant Conflicting interpretations of pathogenicity rs72549411 GRCh38 Chromosome 3, 38586046: 38586046
45 SCN5A NM_198056.2(SCN5A): c.3873G> A (p.Leu1291=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313033 GRCh37 Chromosome 3, 38603996: 38603996
46 SCN5A NM_198056.2(SCN5A): c.3873G> A (p.Leu1291=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313033 GRCh38 Chromosome 3, 38562505: 38562505
47 SCN5A NM_198056.2(SCN5A): c.1569T> A (p.Arg523=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313693 GRCh37 Chromosome 3, 38645524: 38645524
48 SCN5A NM_198056.2(SCN5A): c.1569T> A (p.Arg523=) single nucleotide variant Conflicting interpretations of pathogenicity rs41313693 GRCh38 Chromosome 3, 38604033: 38604033
49 SCN5A NM_198056.2(SCN5A): c.6003C> T (p.Leu2001=) single nucleotide variant Conflicting interpretations of pathogenicity rs538707712 GRCh37 Chromosome 3, 38591860: 38591860
50 SCN5A NM_198056.2(SCN5A): c.6003C> T (p.Leu2001=) single nucleotide variant Conflicting interpretations of pathogenicity rs538707712 GRCh38 Chromosome 3, 38550369: 38550369

Expression for Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for Sick Sinus Syndrome

GO Terms for Sick Sinus Syndrome

Cellular components related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercalated disc GO:0014704 9.16 RANGRF SCN5A
2 sarcolemma GO:0042383 9.13 CACNA1C SCN5A SNTA1
3 Z disc GO:0030018 8.92 CACNA1C MYH6 SCN5A TTN

Biological processes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.74 CACNA1C HCN4 SCN5A
2 sarcomere organization GO:0045214 9.6 MYH6 TTN
3 muscle filament sliding GO:0030049 9.59 MYH6 TTN
4 embryonic forelimb morphogenesis GO:0035115 9.58 CACNA1C SHOX2
5 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.58 SCN5A SNTA1
6 cardiac muscle contraction GO:0060048 9.58 MYH6 SCN5A TTN
7 ventricular cardiac muscle cell action potential GO:0086005 9.56 SCN5A SNTA1
8 muscle contraction GO:0006936 9.56 HCN4 MYH6 SNTA1 TTN
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.55 CACNA1C SCN5A
10 cardiac muscle fiber development GO:0048739 9.54 MYH6 TTN
11 striated muscle contraction GO:0006941 9.52 MYH6 TTN
12 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.51 HCN4 RANGRF
13 regulation of heart rate by cardiac conduction GO:0086091 9.5 CACNA1C HCN4 SCN5A
14 regulation of membrane depolarization GO:0003254 9.49 HCN4 RANGRF
15 SA node cell action potential GO:0086015 9.48 HCN4 SCN5A
16 membrane depolarization during AV node cell action potential GO:0086045 9.46 CACNA1C SCN5A
17 membrane depolarization during SA node cell action potential GO:0086046 9.43 HCN4 SCN5A
18 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.37 CACNA1C SCN5A
19 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.33 CACNA1C HCN4 SCN5A
20 regulation of sodium ion transmembrane transport GO:1902305 9.13 RANGRF SCN5A SNTA1
21 regulation of heart rate GO:0002027 9.02 HCN4 MYH6 RANGRF SCN5A SNTA1

Molecular functions related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.54 CACNA1C HCN4 SCN5A
2 sodium channel regulator activity GO:0017080 9.43 RANGRF SNTA1
3 ion channel binding GO:0044325 9.43 RANGRF SCN5A SNTA1
4 sodium channel activity GO:0005272 9.4 HCN4 SCN5A
5 voltage-gated sodium channel activity GO:0005248 9.32 HCN4 SCN5A
6 nitric-oxide synthase binding GO:0050998 9.16 SCN5A SNTA1
7 voltage-gated ion channel activity GO:0005244 9.13 CACNA1C HCN4 SCN5A
8 calmodulin binding GO:0005516 9.02 CACNA1C MYH6 SCN5A SNTA1 TTN

Sources for Sick Sinus Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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