Sick Sinus Syndrome (SND)

Categories: Cardiovascular diseases, Genetic diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Sick Sinus Syndrome

MalaCards integrated aliases for Sick Sinus Syndrome:

Name: Sick Sinus Syndrome 12 43 36 54 6 44 15 70 32
Sinus Node Dysfunction 43 70
Sinus Node Disease 43 6
Sinus Node Infection 12
Sss 43
Snd 43


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Disease Ontology 12 DOID:13884
KEGG 36 H00729
MeSH 44 D012804
NCIt 50 C62244
SNOMED-CT 67 266307005
ICD10 32 I49.5
UMLS 70 C0037052 C0428908

Summaries for Sick Sinus Syndrome

MedlinePlus Genetics : 43 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.Sick sinus syndrome tends to cause the heartbeat to be too slow (bradycardia), although occasionally the heartbeat is too fast (tachycardia). In some cases, the heartbeat rapidly switches from being too fast to being too slow, a condition known as tachycardia-bradycardia syndrome. Symptoms related to abnormal heartbeats can include dizziness, light-headedness, fainting (syncope), a sensation of fluttering or pounding in the chest (palpitations), and confusion or memory problems. During exercise, many affected individuals experience chest pain, difficulty breathing, or excessive tiredness (fatigue). Once symptoms of sick sinus syndrome appear, they usually worsen with time. However, some people with the condition never experience any related health problems.Sick sinus syndrome occurs most commonly in older adults, although it can be diagnosed in people of any age. The condition increases the risk of several life-threatening problems involving the heart and blood vessels. These include a heart rhythm abnormality called atrial fibrillation, heart failure, cardiac arrest, and stroke.

MalaCards based summary : Sick Sinus Syndrome, also known as sinus node dysfunction, is related to sick sinus syndrome 1 and sick sinus syndrome 3. An important gene associated with Sick Sinus Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and Neuroscience. The drugs Nebivolol and Atenolol have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

KEGG : 36 Sick sinus syndrome (SSS) comprises a variety of conditions involving sinus node dysfunction and commonly affects elderly persons. Patients may experience syncope, pre-syncope, palpitations, or dizziness. SSS has multiple manifestations on electrocardiogram, including sinus bradycardia, sinus arrest, sinoatrial block, and alternating patterns of bradycardia and tachycardia. Autosomal recessive type (SSS1) can be caused by compound heterozygous mutation in the SCN5A gene, and autosomal dominant type (SSS2) can be caused by heterozygous mutation in the HCN4. SCN5A encodes an alpha-subunit of the cardiac sodium channel carrying the current to form a rapid upstroke of action potential, whereas HCN4 codes for an alpha-subunit of hyperpolarization-activated cation channel.

Wikipedia : 73 Sinus node dysfunction (SND), also known as sick sinus syndrome (SSS), is a group of abnormal heart... more...

Related Diseases for Sick Sinus Syndrome

Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 2 Sick Sinus Syndrome 1
Sick Sinus Syndrome 3 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 sick sinus syndrome 1 33.4 SCN5A LOC110121269
2 sick sinus syndrome 3 33.3 MYH6 LOC114827851
3 familial sick sinus syndrome 32.7 SCN5A MYH6 MECP2 HCN4 AGT
4 cardiac arrhythmia, ankyrin-b-related 31.8 SNTA1 SCN5A CACNA1C ANK2
5 syncope 31.6 TTN SCN5A NPPA
6 brugada syndrome 1 31.1 SCN5A SCN10A LOC110121269
7 atrioventricular block 31.0 TTN SCN5A LMNA HCN4 GJA5 CACNA1C
8 progressive familial heart block, type ia 30.8 SCN5A GJA5 ANK2
9 first-degree atrioventricular block 30.7 SCN5A LMNA
10 right bundle branch block 30.6 SCN5A SCN1B RANGRF HCN4 CACNA1C
11 heart septal defect 30.5 NPPA MYH6 GJA5 F2
12 cardiac conduction defect 30.5 SCN5A SCN1B MYH6 LMNA CACNA1C
13 atrial standstill 30.4 SCN5A NPPA GJA5
14 heart valve disease 30.4 TGFB1 NPPA MYH6 F2
15 second-degree atrioventricular block 30.4 SCN5A HCN4
16 sinoatrial node disease 30.3 SCN5A SCN1B RANGRF MYH6 HCN4 GJA5
17 congestive heart failure 30.3 TTN SCN5A NPPA MYH6 CACNA1C AGT
18 mitral valve insufficiency 30.2 TTN NPPA MYH6 F2
19 wolff-parkinson-white syndrome 30.2 TTN SCN5A MYH6
20 restrictive cardiomyopathy 30.2 TTN MYH6 LMNA CACNA1C
21 cardiac arrest 30.2 TTN SCN5A MYH6 HCN4 ANK2
22 familial long qt syndrome 30.1 SNTA1 SCN5A LOC110121269 ANK2
23 mitral valve disease 30.1 NPPA MYH6 F2 AGT
24 brugada syndrome 5 30.1 SCN5A SCN1B LMNA
25 ebstein anomaly 30.0 SCN5A MYH6 HCN4 GJA5
26 tetralogy of fallot 30.0 SCN5A NPPA MYH6 GJA5
27 systolic heart failure 30.0 TTN NPPA AGT
28 atrial standstill 1 30.0 TTN SCN5A SCN1B MYH6 LMNA GJA5
29 cardiomyopathy, dilated, 1e 30.0 TTN SCN5A LMNA
30 cardiac arrhythmia 29.9 SCN5A SCN1B RANGRF LOC110121269 CACNA1C ANK2
31 sudden infant death syndrome 29.9 SNTA1 SCN5A SCN1B LOC110121269
32 atrial heart septal defect 29.9 TTN SCN5A NPPA MYH6 HCN4 GJA5
33 aortic valve disease 2 29.8 TTN NPPA MYH6 AGT
34 holt-oram syndrome 29.8 NPPA MYH6 LMNA GJA5
35 diastolic heart failure 29.7 TTN TGFB1 NPPA AGT
36 respiratory failure 29.7 TTN NPPA MECP2 F2
37 third-degree atrioventricular block 29.6 TTN SCN5A SCN1B HCN4 GJA5
38 long qt syndrome 3 29.6 SNTA1 SCN5A SCN1B LOC110121269 CACNA1C ANK2
39 arrhythmogenic right ventricular cardiomyopathy 29.5 TTN SCN5A MYH6 LMNA HCN4 CACNA1C
40 long qt syndrome 2 29.2 SNTA1 SCN5A SCN1B MYH6 HCN4 CACNA1C
41 hypertension, essential 29.2 TGFB1 NPPA MYH6 GJA5 F2 CACNA1C
42 atrial fibrillation 29.0 TTN SNTA1 SCN5A SCN1B NPPA LMNA
43 long qt syndrome 1 28.9 SNTA1 SCN5A SCN1B SCN10A RANGRF MYH6
44 brugada syndrome 28.9 TTN SNTA1 SCN5A SCN1B SCN10A RANGRF
45 long qt syndrome 28.8 TTN SNTA1 SCN5A SCN1B MYH6 LOC110121269
46 lipoprotein quantitative trait locus 28.8 TTN SCN5A NPPA MYH6 LMNA HCN4
47 catecholaminergic polymorphic ventricular tachycardia 28.7 SNTA1 SCN5A SCN1B MYH6 LMNA HCN4
48 hypertrophic cardiomyopathy 28.5 TTN TGFB1 SCN5A SCN10A NPPA MYH6
49 left ventricular noncompaction 28.4 TTN SNTA1 SCN5A SCN1B RANGRF MYH6
50 dilated cardiomyopathy 28.2 TTN TGFB1 SNTA1 SCN5A NPPA MYH6

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:

Diseases related to Sick Sinus Syndrome

Symptoms & Phenotypes for Sick Sinus Syndrome

GenomeRNAi Phenotypes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.4 TGFB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.4 ANK2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.4 ANK2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-12 9.4 SCN5A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.4 TGFB1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.4 SCN1B
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-143 9.4 TGFB1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.4 SCN5A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-155 9.4 ANK2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-37 9.4 ANK2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-56 9.4 TGFB1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.4 ANK2

MGI Mouse Phenotypes related to Sick Sinus Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 AGT CACNA1C F2 LMNA MECP2 MYH6
2 cardiovascular system MP:0005385 10.22 AGT CACNA1C F2 GJA5 HCN4 LMNA
3 homeostasis/metabolism MP:0005376 10.21 AGT CACNA1C F2 GJA5 LMNA MECP2
4 mortality/aging MP:0010768 10.13 AGT CACNA1C F2 GJA5 HCN4 LMNA
5 muscle MP:0005369 10.03 AGT CACNA1C F2 GJA5 HCN4 LMNA
6 nervous system MP:0003631 9.9 AGT CACNA1C F2 HCN4 LMNA MECP2
7 normal MP:0002873 9.56 F2 GJA5 HCN4 LMNA MECP2 SCN1B
8 respiratory system MP:0005388 9.23 F2 GJA5 LMNA MECP2 MYH6 SCN10A

Drugs & Therapeutics for Sick Sinus Syndrome

Drugs for Sick Sinus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
Atenolol Approved Phase 4 29122-68-7 2249
Ethanol Approved Phase 4 64-17-5 702
4 Adrenergic beta-Agonists Phase 4
5 Adrenergic Antagonists Phase 4
6 Vasodilator Agents Phase 4
7 Sympatholytics Phase 4
8 Adrenergic Agents Phase 4
9 Neurotransmitter Agents Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic beta-1 Receptor Antagonists Phase 4
12 Antihypertensive Agents Phase 4
Ofloxacin Approved Phase 3 82419-36-1 4583
Polymyxin B Approved, Vet_approved Phase 3 1404-26-8
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 10909430 439542
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
19 Antibiotics, Antitubercular Phase 3
20 Cytochrome P-450 Enzyme Inhibitors Phase 3
21 Polymyxins Phase 3
22 Anti-Bacterial Agents Phase 3
23 Clindamycin phosphate Phase 3
24 Anti-Infective Agents, Local Phase 3
25 Clindamycin palmitate Phase 3
26 Anti-Infective Agents Phase 3
Angiotensin II Approved, Investigational 68521-88-0, 11128-99-7, 4474-91-3 172198
Losartan Approved 114798-26-4 3961
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
Thrombin Approved, Investigational
Digoxin Approved 20830-75-5 30322 2724385
Amiodarone Approved, Investigational 1951-25-3 2157
Propafenone Approved 54063-53-5 4932
Dronedarone Approved 141626-36-0, 141625-93-6 154087
Imidacloprid Vet_approved 105827-78-9 86418
37 Angiotensinogen
38 Giapreza
39 Angiotensin Receptor Antagonists
40 Angiotensin II Type 1 Receptor Blockers
41 Pharmaceutical Solutions
42 Hemostatics
43 Coagulants
44 Anti-Arrhythmia Agents
45 Adrenergic beta-Antagonists

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 A Randomized, Prospective Multicenter Study to Determine the Incidence of Atrial Fibrillation and Heart Failure in Correlation to Stimulation Modes of Pacemakers Unknown status NCT00161551 Phase 4
2 IntAct, Study on Promotion of Intrinsic Activity. Unknown status NCT00156741 Phase 4
3 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
4 The Impact of Heart Rate on Central Hemodynamics in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker Completed NCT03245996 Phase 4 Atenolol Pill;Nebivolol Pill;Ivabradine Pill
5 Prevention of Atrial Arrhythmia in Patients Without AV Conduction Disease Completed NCT01170611 Phase 4
6 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
7 A Randomized, Prospective Multicenter Study to Examine the Optimal Position of the Atrial Leads for Therapy of the Sinus Node Syndrome Completed NCT00161538 Phase 4
8 Analyse Der Unterschiede Zwischen Aktiv-fixierenden Und Passiv-fixierenden Stimulations-Elektroden Hinsichtlich Implantationsdauer Und Elektrischer Parameter Completed NCT00180557 Phase 4
9 Falls and Cardiovascular Events in Elderly Patients With Sinus Node Disease Treated With a MVPTM Pacemaker According to the ESC 2007 Guidelines Completed NCT01037426 Phase 4
10 VIRTUE: Virtual Clinic Pacemaker Follow-up Terminated NCT00475124 Phase 4
11 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation Completed NCT02317068 Phase 3
12 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
13 Randomized Noninferiority Study of an Antibacterial Envelope Alone Versus Envelope Plus Intraoperative Antibacterial Irrigant and Postoperative Antibiotics to Prevent Cardiac Implantable Electronic Device Infections in High-Risk Patients Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
14 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
15 Minimizing Right Ventricular Pacing in Dual-chamber Pacemaker Patients With Sinus Node Disease and First Degree Atrioventricular Block. Unknown status NCT01611389
16 Comparison of Right Ventricular Septal Pacing to Minimized Right Ventricular Septal Stimulation in Patients With Sick Sinus Syndrome Unknown status NCT01477138
17 Multi-center, Randomized, Controlled Trial to Compare Feasibility, Safety and Efficacy of Zero-Fluoroscopic Navigation With Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Unknown status NCT03118440
18 Multi-center, Randomized, Controlled Trial to Compare Feasibility, Safety and Efficacy of Zero-Fluoroscopic Navigation With Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Unknown status NCT03118427
19 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
20 The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome Unknown status NCT01310920
21 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
22 The Effect of Losartan on Atrial Fibrillation and Pacemaker Dependence in Sick Sinus Syndrome (SSS) Patients Receiving Physiological Pacemaker - A Prospective, Randomized, Multicenter Study in Taiwan Unknown status NCT00647257 Losartan;Placebo
23 Left Ventricular Pacing to Prevent Iatrogenic Tricuspid Regurgitation Caused by Conventional Right Ventricular Pacing: a Pilot Study Unknown status NCT02314897
24 Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position - Right Pace Study Unknown status NCT01647490
25 Impact of Left Ventricular Pacing on Left Ventricular Systolic Function in High-risk Bradycardia Patients Unknown status NCT01302717
26 INGEVITY(TM) Active Fixation and Passive Fixation Pace/ Sense Lead Clinical Study Completed NCT01688843
27 Effectiveness of Closed Loop Stimulation (CLS) With His Bundle Lead Placement Completed NCT03601754
28 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Completed NCT01643707
29 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction. Completed NCT02027909
30 Right Ventricular Outflow Tract Septal Pacing for Cardiac Dysfunction Prevention Evaluation Completed NCT01294839
31 Evolution of the PR Interval in Patients Implanted With a Dual Chamber Pacemaker With Algorithm for Spontaneous AV Conduction Preservation Completed NCT02586480
32 Comparison of Ventricular Septal Pacing With Optimized Atrioventricular (AV) Delay to no Pacing in Sinus Node Disease (SND) Patients. Completed NCT02485093
33 Ingenio Device Algorithm Study Completed NCT01441583
34 AV-Hysteresis Versus Mode Switch to AAI (MVP) for the Avoidance of Unnecessary Right Ventricular Pacing Completed NCT01803217
35 Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction (SAVE PACe) Completed NCT00284830
36 His Bundle Pacing Device Electrogram Data Collection Completed NCT03564860
37 Imaging Cardiac Electrical Remodeling With ECGI Completed NCT00785564
38 Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study Completed NCT01528657
39 Does a Measure Exist in the Right Ventricle Which Can Act as a Surrogate Marker for Future Ventriclar Sysfunction When Pacing - a Pilot Study Completed NCT02198781
40 Preserve Registry: Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class Completed NCT00292539
41 ImageReady(TM) MR Conditional Pacing System Clinical Study Completed NCT01781078
42 Registry to Improve the Adoption of Consensus Treatment Guideline (Brady MX) Completed NCT02976181
43 Second Study on Cardio-neuromodulation in Humans Completed NCT02954666
44 Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858
45 Phase IV Long Term Observational Study of Patients Implanted With Medtronic CRDM Implantable Cardiac Devices Completed NCT00382525
46 Diagnostic Data Influence on Disease Management and Relation of Genetic Polymorphisms to Tachy-arrhythmia in ICD Patients. Completed NCT00478933
47 The Atrial High Rate Episodes (A-HIRATE) in Pacemaker Patients Completed NCT00627328
48 Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm. Completed NCT00832260
49 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum - Feasibility, Long-term Lead Stability and Safety Completed NCT01609738
50 Registry on Automatic Algorhitm on Atrial Capture: REAL ACap Registry Completed NCT02400983

Search NIH Clinical Center for Sick Sinus Syndrome

Cochrane evidence based reviews: sick sinus syndrome

Genetic Tests for Sick Sinus Syndrome

Anatomical Context for Sick Sinus Syndrome

MalaCards organs/tissues related to Sick Sinus Syndrome:

Heart, Atrioventricular Node, Endothelial, Cardiac Myocytes, Spleen, Skeletal Muscle, Thyroid

Publications for Sick Sinus Syndrome

Articles related to Sick Sinus Syndrome:

(show top 50) (show all 3575)
# Title Authors PMID Year
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. 61 6
18451998 2008
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
Genetic variants in SCN5A promoter are associated with arrhythmia phenotype severity in patients with heterozygous loss-of-function mutation. 6
22370247 2012
Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay. 6
22090166 2012
An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. 6
20129283 2010
Congenital long-QT syndrome caused by a novel mutation in a conserved acidic domain of the cardiac Na+ channel. 6
10377081 1999
Sick sinus syndrome, progressive cardiac conduction disease, atrial flutter and ventricular tachycardia caused by a novel SCN5A mutation. 54 61
20395683 2010
Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology. 61 54
19744495 2010
Mouse models of SCN5A-related cardiac arrhythmias. 61 54
19041666 2008
A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia. 61 54
17897635 2007
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). 61 54
14523039 2003
[An intrapatient comparison of adaptation to aerobic and anaerobic exertion during 3 types of physiological cardiac stimulation in chronotropic failure of the sinus node: DDD, VVIR and DDDR]. 61 54
9118155 1997
[Secretion of atrial natriuretic peptide during artificial pacing: assessments including the influence of ventriculoatrial conduction]. 61 54
1307573 1992
Acute Endovascular Revascularization for Patients with Common Carotid Artery Occlusion Apparent on Cervical Magnetic Resonance Angiography. 61
33516069 2021
Expanding the phenotype of CACNA1C mutation disorders. 61
33797204 2021
Clinical course of sinus node dysfunction after thoracoscopic surgery for atrial fibrillation-analysis of the Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery (AFACT) study. 61
32172425 2021
The multisystem nature of isomerism: left isomerism complicated by Abernethy malformation and portopulmonary hypertension. 61
33731242 2021
Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease. 61
33739154 2021
Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. 61
33706013 2021
Post-operative arrhythmias in patients with hypoplastic left heart syndrome and anatomic variants: incidence, type, and course. 61
33685535 2021
Sleep Rate Mode of Pacemaker-Dependent Patients with Sick Sinus Syndrome Increases Dipper Blood Pressure and Dipper Heart Rate Patterns. 61
33731516 2021
Left Atrial Enlargement and Sick Sinus Syndrome for Pacemaker Indication Were Associated with Atrial High Rate Episodes. 61
33655724 2021
Prevalence and Predictors of Clinically Relevant Atrial High-Rate Episodes in Patients with Cardiac Implantable Electronic Devices. 61
33655723 2021
Zenglv Fumai Granule protects cardiomyocytes against hypoxia/reoxygenation-induced apoptosis via inhibiting TRIM28 expression. 61
33398366 2021
Management of Arrhythmias After Heart Transplant: Current State and Considerations for Future Research. 61
33685207 2021
Pathological findings of myocardium in a patient with cardiac conduction defect associated with an SCN5A mutation. 61
33651170 2021
Identification of rare heterozygous linkage R965C-R1309H mutations in the pore-forming region of SCN5A gene associated with complex arrhythmia. 61
33764691 2021
COVID-19-associated multisystem inflammatory syndrome in children presenting uniquely with sinus node dysfunction in the setting of shock. 61
33745461 2021
Permanent pacemaker implantation in unexplained syncope patients with borderline sinus bradycardia and electrophysiology study-proven sinus node disease. 61
33664902 2021
Relapsing polychondritis associated with heart block. 61
33660817 2021
Left ventricular stiffness assessed by diastolic Wall strain predicts asymptomatic atrial high-rate episodes in patients with pacemaker implantation. 61
32888831 2021
The mid-term outcome of Fontan conversion compared with primary total cavopulmonary connection. 61
33648806 2021
Familial sick sinus syndrome possibly associated with novel SCN5A mutation diagnosed in pregnancy. 61
33665115 2021
Pacemaker implantation for sick sinus syndrome in a pregnant female with situs ambiguus and polysplenia. 61
33664913 2021
Genetic insight into sick sinus syndrome. 61
33580673 2021
[Intellectual disorder and idiopathic sick sinus syndrome associated with GNB5 mutation: a case report]. 61
33611908 2021
A novel homozygous SCN5A variant detected in sick sinus syndrome. 61
32965045 2021
Catheter ablation of atrial fibrillation in situs inversus dextrocardia: Challenge, improved procedure, outcomes, and literature review. 61
33372281 2021
Presence of non-pulmonary vein foci in patients with atrial fibrillation undergoing standard ablation of pulmonary vein isolation: Clinical characteristics and long-term ablation outcome. 61
33532545 2021
RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart. 61
33574422 2021
Multiple arrhythmic and cardiomyopathic phenotypes associated with an SCN5A A735E mutation. 61
33610078 2021
Secondary Cardiac Lymphoma Presenting as Sick Sinus Syndrome and Atrial Fibrillation Which Required Leadless Pacemaker Implantation. 61
32963160 2021
Permanent His bundle pacing using a new tridimensional delivery sheath and a standard active fixation pacing lead: The telescopic technique. 61
33410557 2021
Energy loss by right ventricular pacing: Patients with versus without hypertrophic cardiomyopathy. 61
33664904 2021
Screening for ATTR amyloidosis in the clinic: overlapping disorders, misdiagnosis, and multiorgan awareness. 61
33609196 2021
Sinus node disfunction in an adolescent with systemic lupus erythematosus. 61
33215560 2021
Evaluation and Management of Asymptomatic Bradyarrhythmias. 61
32693770 2021
Syncope Associated with Sinus Nodal Dysfunction in a COVID-19 Patient: A Case Report and Review of the Literature. 61
33665366 2021
Mid- to long-term surgical outcomes of partial anomalous pulmonary venous connection. 61
32686032 2021
A comparison of AAIR versus DDDR pacing for patients with sinus node dysfunction: a long-term follow-up study. 61
32946543 2021

Variations for Sick Sinus Syndrome

ClinVar genetic disease variations for Sick Sinus Syndrome:

6 (show all 45)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SCN5A NM_198056.2(SCN5A):c.1936del (p.Gln646fs) Deletion Pathogenic 179829 rs727505158 GRCh37: 3:38640496-38640496
GRCh38: 3:38599005-38599005
2 SCN5A NM_000335.5(SCN5A):c.5347G>A (p.Glu1783Lys) SNV Pathogenic 9377 rs137854601 GRCh37: 3:38592513-38592513
GRCh38: 3:38551022-38551022
3 SCN5A NM_001099404.1(SCN5A):c.1252G>T (p.Glu418Ter) SNV Likely pathogenic 222805 rs869025519 GRCh37: 3:38647528-38647528
GRCh38: 3:38606037-38606037
4 MECP2 NM_001110792.2(MECP2):c.148_152del (p.Glu50fs) Deletion Likely pathogenic 813009 rs1603310867 GRCh37: X:153297919-153297923
GRCh38: X:154032468-154032472
5 SNTA1 NM_003098.2(SNTA1):c.388T>C (p.Phe130Leu) SNV Uncertain significance 190929 rs199964677 GRCh37: 20:32026755-32026755
GRCh38: 20:33438949-33438949
6 HCN4 NM_005477.3(HCN4):c.3498_3501TTTG[1] (p.Phe1168fs) Microsatellite Uncertain significance 191377 rs786205259 GRCh37: 15:73614929-73614932
GRCh38: 15:73322588-73322591
7 SCN5A NM_198056.2(SCN5A):c.*725C>A SNV Uncertain significance 345094 rs886058451 GRCh37: 3:38591087-38591087
GRCh38: 3:38549596-38549596
8 SCN5A NM_198056.2(SCN5A):c.*1969C>T SNV Uncertain significance 345063 rs190416544 GRCh37: 3:38589843-38589843
GRCh38: 3:38548352-38548352
9 SCN5A NM_198056.2(SCN5A):c.4267G>A (p.Asp1423Asn) SNV Uncertain significance 222810 rs746291609 GRCh37: 3:38598754-38598754
GRCh38: 3:38557263-38557263
10 SCN5A NM_198056.2(SCN5A):c.*1673C>T SNV Uncertain significance 345072 rs886058443 GRCh37: 3:38590139-38590139
GRCh38: 3:38548648-38548648
11 SCN5A NM_198056.2(SCN5A):c.687T>C (p.Thr229=) SNV Uncertain significance 345129 rs770390440 GRCh37: 3:38655250-38655250
GRCh38: 3:38613759-38613759
12 SCN5A NM_198056.2(SCN5A):c.*1602G>T SNV Uncertain significance 345073 rs886058444 GRCh37: 3:38590210-38590210
GRCh38: 3:38548719-38548719
13 LOC110121269 , SCN5A NM_000335.5(SCN5A):c.3360G>A (p.Ala1120=) SNV Uncertain significance 48300 rs9858585 GRCh37: 3:38620852-38620852
GRCh38: 3:38579361-38579361
14 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.3228+6C>G SNV Uncertain significance 345120 rs368048551 GRCh37: 3:38622416-38622416
GRCh38: 3:38580925-38580925
15 SCN5A NM_198056.2(SCN5A):c.1598G>A (p.Arg533His) SNV Uncertain significance 180512 rs146848219 GRCh37: 3:38645495-38645495
GRCh38: 3:38604004-38604004
16 SCN5A NM_198056.2(SCN5A):c.21T>A (p.Pro7=) SNV Uncertain significance 139038 rs587781157 GRCh37: 3:38674778-38674778
GRCh38: 3:38633287-38633287
17 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.2988C>T (p.Ala996=) SNV Uncertain significance 345121 rs781529391 GRCh37: 3:38622662-38622662
GRCh38: 3:38581171-38581171
18 SCN5A NM_198056.2(SCN5A):c.1870C>A (p.Leu624Ile) SNV Uncertain significance 345126 rs886058463 GRCh37: 3:38645223-38645223
GRCh38: 3:38603732-38603732
19 SCN5A NM_198056.2(SCN5A):c.*516G>T SNV Uncertain significance 345099 rs886058454 GRCh37: 3:38591296-38591296
GRCh38: 3:38549805-38549805
20 SCN5A NM_198056.2(SCN5A):c.*1836A>T SNV Uncertain significance 345066 rs886058438 GRCh37: 3:38589976-38589976
GRCh38: 3:38548485-38548485
21 SCN5A NM_198056.2(SCN5A):c.*945C>A SNV Uncertain significance 345089 rs886058450 GRCh37: 3:38590867-38590867
GRCh38: 3:38549376-38549376
22 SCN5A NM_198056.2(SCN5A):c.*6G>T SNV Uncertain significance 345110 rs776980213 GRCh37: 3:38591806-38591806
GRCh38: 3:38550315-38550315
23 SCN5A NM_198056.2(SCN5A):c.2259C>T (p.Asn753=) SNV Uncertain significance 345123 rs878911306 GRCh37: 3:38639223-38639223
GRCh38: 3:38597732-38597732
24 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.3384C>T (p.Cys1128=) SNV Uncertain significance 345119 rs561922849 GRCh37: 3:38620831-38620831
GRCh38: 3:38579340-38579340
25 SCN5A NM_198056.2(SCN5A):c.*1443C>A SNV Uncertain significance 345078 rs886058445 GRCh37: 3:38590369-38590369
GRCh38: 3:38548878-38548878
26 SCN5A NM_198056.2(SCN5A):c.5945G>T (p.Arg1982Ile) SNV Uncertain significance 345113 rs774432823 GRCh37: 3:38591918-38591918
GRCh38: 3:38550427-38550427
27 SCN5A NM_198056.2(SCN5A):c.*1701G>T SNV Uncertain significance 345070 rs886058441 GRCh37: 3:38590111-38590111
GRCh38: 3:38548620-38548620
28 SCN5A NM_000335.5(SCN5A):c.1569T>A (p.Arg523=) SNV Uncertain significance 165155 rs41313693 GRCh37: 3:38645524-38645524
GRCh38: 3:38604033-38604033
29 SCN5A NM_198056.2(SCN5A):c.*1705C>T SNV Uncertain significance 345069 rs886058440 GRCh37: 3:38590107-38590107
GRCh38: 3:38548616-38548616
30 LOC110121269 , SCN5A NM_198056.2(SCN5A):c.2815C>T (p.Leu939Phe) SNV Uncertain significance 345122 rs886058462 GRCh37: 3:38622835-38622835
GRCh38: 3:38581344-38581344
31 SCN5A NM_000335.5(SCN5A):c.1068T>C (p.Asp356=) SNV Uncertain significance 165156 rs41313703 GRCh37: 3:38648232-38648232
GRCh38: 3:38606741-38606741
32 SCN5A NM_198056.2(SCN5A):c.*1691G>T SNV Uncertain significance 345071 rs886058442 GRCh37: 3:38590121-38590121
GRCh38: 3:38548630-38548630
33 SCN5A NM_198056.2(SCN5A):c.*1731G>C SNV Uncertain significance 345068 rs569249327 GRCh37: 3:38590081-38590081
GRCh38: 3:38548590-38548590
34 SCN5A NM_198056.2(SCN5A):c.*980C>A SNV Uncertain significance 345086 rs886058449 GRCh37: 3:38590832-38590832
GRCh38: 3:38549341-38549341
35 SCN5A NM_198056.2(SCN5A):c.6033C>A (p.Asp2011Glu) SNV Uncertain significance 345111 rs886058459 GRCh37: 3:38591830-38591830
GRCh38: 3:38550339-38550339
36 SCN5A NM_198056.2(SCN5A):c.*634C>A SNV Uncertain significance 345098 rs886058453 GRCh37: 3:38591178-38591178
GRCh38: 3:38549687-38549687
37 SCN5A NM_198056.2(SCN5A):c.*2149G>A SNV Uncertain significance 345060 rs114517792 GRCh37: 3:38589663-38589663
GRCh38: 3:38548172-38548172
38 SCN5A NM_198056.2(SCN5A):c.*73C>A SNV Uncertain significance 345109 rs886058458 GRCh37: 3:38591739-38591739
GRCh38: 3:38550248-38550248
39 SCN5A NM_198056.2(SCN5A):c.*1744C>G SNV Uncertain significance 345067 rs886058439 GRCh37: 3:38590068-38590068
GRCh38: 3:38548577-38548577
40 SCN5A NM_198056.2(SCN5A):c.*296G>A SNV Uncertain significance 345103 rs886058456 GRCh37: 3:38591516-38591516
GRCh38: 3:38550025-38550025
41 SCN5A NM_198056.2(SCN5A):c.*1943C>A SNV Uncertain significance 345064 rs569552176 GRCh37: 3:38589869-38589869
GRCh38: 3:38548378-38548378
42 SCN5A NM_198056.2(SCN5A):c.*2145_*2146insGAGAAGAGAGTAGGAAAAAGGAGGG Insertion Likely benign 345061 rs45592631 GRCh37: 3:38589666-38589667
GRCh38: 3:38548175-38548176
43 SCN5A NM_000335.4(SCN5A):c.*1453dup Duplication Likely benign 345077 rs397763929 GRCh37: 3:38590358-38590359
GRCh38: 3:38548867-38548868
44 SCN5A NM_198056.2(SCN5A):c.3893C>T (p.Pro1298Leu) SNV not provided 9394 rs28937319 GRCh37: 3:38603976-38603976
GRCh38: 3:38562485-38562485
45 SCN5A NM_198056.2(SCN5A):c.1076C>A (p.Ala359Asp) SNV not provided 440929 rs1553704925 GRCh37: 3:38648224-38648224
GRCh38: 3:38606733-38606733

Expression for Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for Sick Sinus Syndrome

Pathways related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
7 11.36 TGFB1 SCN5A MYH6
Show member pathways
9 11.1 SCN5A SCN1B SCN10A ANK2

GO Terms for Sick Sinus Syndrome

Cellular components related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcolemma GO:0042383 9.62 SNTA1 SCN5A CACNA1C ANK2
2 T-tubule GO:0030315 9.46 SCN5A SCN1B CACNA1C ANK2
3 voltage-gated sodium channel complex GO:0001518 9.43 SCN5A SCN1B SCN10A
4 Z disc GO:0030018 9.35 TTN SCN5A MYH6 CACNA1C ANK2
5 intercalated disc GO:0014704 9.02 SCN5A SCN1B RANGRF GJA5 ANK2

Biological processes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.91 SCN5A SCN1B SCN10A HCN4
2 regulation of ion transmembrane transport GO:0034765 9.89 SCN5A SCN1B SCN10A HCN4 CACNA1C
3 muscle contraction GO:0006936 9.87 TTN SNTA1 MYH6 HCN4
4 sodium ion transmembrane transport GO:0035725 9.86 SCN5A SCN1B SCN10A HCN4
5 female pregnancy GO:0007565 9.85 TGFB1 NPPA AGT
6 cellular response to mechanical stimulus GO:0071260 9.84 TGFB1 NPPA AGT
7 regulation of blood pressure GO:0008217 9.83 NPPA MYH6 AGT
8 odontogenesis of dentin-containing tooth GO:0042475 9.81 TGFB1 SCN5A SCN10A
9 cardiac conduction GO:0061337 9.8 SCN5A SCN1B CACNA1C
10 cardiac muscle contraction GO:0060048 9.78 TTN SCN5A SCN1B MYH6
11 ventricular cardiac muscle cell action potential GO:0086005 9.7 SNTA1 SCN5A ANK2
12 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.69 TGFB1 AGT
13 membrane depolarization during action potential GO:0086010 9.69 SCN5A SCN10A
14 cell growth involved in cardiac muscle cell development GO:0061049 9.69 NPPA AGT
15 cardiac muscle cell action potential involved in contraction GO:0086002 9.69 SCN5A SCN1B CACNA1C
16 positive regulation of cellular protein metabolic process GO:0032270 9.68 TGFB1 AGT
17 positive regulation of sodium ion transport GO:0010765 9.68 SCN5A SCN1B
18 striated muscle contraction GO:0006941 9.68 TTN MYH6
19 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.68 GJA5 CACNA1C
20 regulation of cardiac muscle cell contraction GO:0086004 9.67 SCN5A ANK2
21 cardiac muscle hypertrophy in response to stress GO:0014898 9.67 NPPA MYH6
22 regulation of cardiac muscle contraction GO:0055117 9.67 SCN10A HCN4 GJA5 ANK2
23 atrial cardiac muscle cell action potential GO:0086014 9.66 SCN5A ANK2
24 atrial septum development GO:0003283 9.65 GJA5 ANK2
25 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.65 RANGRF HCN4
26 cardiac muscle fiber development GO:0048739 9.64 TTN MYH6
27 regulation of membrane depolarization GO:0003254 9.64 RANGRF HCN4
28 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.63 SCN5A NPPA
29 regulation of sodium ion transmembrane transport GO:1902305 9.63 SNTA1 SCN5A RANGRF
30 membrane depolarization during AV node cell action potential GO:0086045 9.62 SCN5A CACNA1C
31 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.62 SNTA1 SCN5A SCN1B ANK2
32 AV node cell action potential GO:0086016 9.61 SCN5A SCN10A
33 membrane depolarization during SA node cell action potential GO:0086046 9.61 SCN5A HCN4 ANK2
34 positive regulation of histone H3-K9 trimethylation GO:1900114 9.6 MECP2 LMNA
35 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.59 SCN5A CACNA1C
36 regulation of atrial cardiac muscle cell action potential GO:0098910 9.58 GJA5 ANK2
37 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.58 SCN5A SCN1B
38 SA node cell action potential GO:0086015 9.58 SCN5A HCN4 ANK2
39 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.56 SCN5A SCN1B HCN4 CACNA1C
40 regulation of bundle of His cell action potential GO:0098905 9.55 RANGRF GJA5
41 regulation of heart rate by cardiac conduction GO:0086091 9.55 SCN5A SCN1B HCN4 CACNA1C ANK2
42 bundle of His cell action potential GO:0086043 9.54 SCN5A SCN10A
43 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.26 SCN5A SCN1B SCN10A GJA5
44 regulation of heart rate GO:0002027 9.23 SNTA1 SCN5A SCN10A RANGRF MYH6 HCN4

Molecular functions related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.76 SCN5A SCN10A HCN4 CACNA1C
2 calmodulin binding GO:0005516 9.72 TTN SNTA1 SCN5A MYH6 CACNA1C
3 voltage-gated ion channel activity GO:0005244 9.65 SCN5A SCN1B SCN10A HCN4 CACNA1C
4 sodium channel regulator activity GO:0017080 9.58 SNTA1 SCN1B RANGRF
5 nitric-oxide synthase binding GO:0050998 9.48 SNTA1 SCN5A
6 sodium channel activity GO:0005272 9.46 SCN5A SCN1B SCN10A HCN4
7 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.43 SCN5A SCN1B
8 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.37 SCN5A SCN1B
9 voltage-gated sodium channel activity GO:0005248 9.26 SCN5A SCN1B SCN10A HCN4
10 ion channel binding GO:0044325 9.1 SNTA1 SCN5A SCN1B SCN10A RANGRF ANK2

Sources for Sick Sinus Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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