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MCID: SCK017
MIFTS: 22
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Sick Sinus Syndrome 1
Categories:
Genetic diseases, Cardiovascular diseases, Muscle diseases, Rare diseases
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MalaCards integrated aliases for Sick Sinus Syndrome 1:
Characteristics:OMIM:57
Inheritance:
autosomal recessive
Miscellaneous:
onset in utero, infancy, or early childhood HPO:32
sick sinus syndrome 1:
Inheritance autosomal dominant inheritance autosomal recessive inheritance Onset and clinical course congenital onset Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Anatomical: Cardiovascular diseases Muscle diseases |
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OMIM
:
57
The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder (Benson et al., 2003).
(608567)
MalaCards based summary : Sick Sinus Syndrome 1, also known as sick sinus syndrome 1, autosomal recessive, is related to sick sinus syndrome 2 and sick sinus syndrome 3. An important gene associated with Sick Sinus Syndrome 1 is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5). Affiliated tissues include heart, and related phenotypes are prolonged qt interval and atrioventricular block UniProtKB/Swiss-Prot : 75 Sick sinus syndrome 1: The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS1 onset is in utero, infancy, or early childhood. |
Diseases in the Sick Sinus Syndrome family:
Diseases related to Sick Sinus Syndrome 1 via text searches within MalaCards or GeneCards Suite gene sharing:
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Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:608567Human phenotypes related to Sick Sinus Syndrome 1:32
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MalaCards organs/tissues related to Sick Sinus Syndrome 1:41
Heart
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Genes related to Sick Sinus Syndrome 1 (1 elite genes):
- Elite gene
- Cancer Census gene in COSMIC
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UniProtKB/Swiss-Prot genetic disease variations for Sick Sinus Syndrome 1:75
ClinVar genetic disease variations for Sick Sinus Syndrome 1:6
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Search
GEO
for disease gene expression data for Sick Sinus Syndrome 1.
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