SSS3
MCID: SCK022
MIFTS: 23

Sick Sinus Syndrome 3 (SSS3)

Categories: Cardiovascular diseases, Genetic diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Sick Sinus Syndrome 3

MalaCards integrated aliases for Sick Sinus Syndrome 3:

Name: Sick Sinus Syndrome 3 57 72 13
Sick Sinus Syndrome 3, Susceptibility to 57 29 6
Sss3 57 72
Sinus, Sick, Syndrome, Type 3, Susceptibility to 39

Classifications:



External Ids:

OMIM® 57 614090
OMIM Phenotypic Series 57 PS608567
MeSH 44 D012804
MedGen 41 C3279791

Summaries for Sick Sinus Syndrome 3

UniProtKB/Swiss-Prot : 72 Sick sinus syndrome 3: The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors.

MalaCards based summary : Sick Sinus Syndrome 3, also known as sick sinus syndrome 3, susceptibility to, is related to sick sinus syndrome and coronary heart disease 1. An important gene associated with Sick Sinus Syndrome 3 is MYH6 (Myosin Heavy Chain 6). Affiliated tissues include heart.

OMIM® : 57 Sick sinus syndrome may be encountered at any age but is primarily a disease of the elderly and is often secondary to other cardiac disorders when diagnosed in younger individuals. Symptoms are often intermittent and/or nonspecific and include dizziness, syncope, and heart failure. The only effective treatment for symptomatic and irreversible sinus node dysfunction is permanent cardiac pacing, and sick sinus syndrome remains the most common indication for permanent pacemaker implantation (summary by Holm et al., 2011). For a general phenotypic description and a discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567). (614090) (Updated 20-May-2021)

Related Diseases for Sick Sinus Syndrome 3

Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 2 Sick Sinus Syndrome 1
Sick Sinus Syndrome 3 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 sick sinus syndrome 29.8 MYH6 LOC114827851
2 coronary heart disease 1 10.0
3 venous insufficiency 10.0
4 hypokalemia 10.0
5 atrial septal defect 3 9.7 MYH6 LOC114827851
6 scapuloperoneal myopathy 9.6 MYH6 LOC114827851
7 myopathy, distal, 1 9.6 MYH6 LOC114827851
8 left ventricular noncompaction 9.5 MYH6 LOC114827851

Graphical network of the top 20 diseases related to Sick Sinus Syndrome 3:



Diseases related to Sick Sinus Syndrome 3

Symptoms & Phenotypes for Sick Sinus Syndrome 3

Clinical features from OMIM®:

614090 (Updated 20-May-2021)

Drugs & Therapeutics for Sick Sinus Syndrome 3

Search Clinical Trials , NIH Clinical Center for Sick Sinus Syndrome 3

Genetic Tests for Sick Sinus Syndrome 3

Genetic tests related to Sick Sinus Syndrome 3:

# Genetic test Affiliating Genes
1 Sick Sinus Syndrome 3, Susceptibility to 29 MYH6

Anatomical Context for Sick Sinus Syndrome 3

MalaCards organs/tissues related to Sick Sinus Syndrome 3:

40
Heart

Publications for Sick Sinus Syndrome 3

Articles related to Sick Sinus Syndrome 3:

(show all 12)
# Title Authors PMID Year
1
A rare variant in MYH6 is associated with high risk of sick sinus syndrome. 57 6
21378987 2011
2
Three STIGMA AND STYLE STYLISTs Pattern the Fine Architectures of Apical Gynoecium and Are Critical for Male Gametophyte-Pistil Interaction. 61
33007250 2020
3
[Indications for His bundle and left bundle branch pacing]. 61
32385573 2020
4
Use of HIV Screening Services and Sexual Behavior of In-School Adolescents in Surulere LGA, Lagos State. 61
27295814 2015
5
Prognostic value of myocardium perfusion imaging with a new reconstruction algorithm. 61
24281904 2014
6
Survey of knowledge of HIV infection among senior secondary school 3 (SSS3) students in Port Harcourt. 61
15523869 2004
7
[Electrophysiological and clinical characterization of left atrial macroreentrant tachycardia]. 61
11784523 2002
8
A population-based study of stroke in the setting of mitral valve prolapse: risk factors and infarct subtype classification. 61
8015325 1994
9
[A case from practice (234). Torsades de pointes under quinidine therapy and diuretic-induced hypokalemia. 2. Hypertension and coronary heart disease - tachycardia with atrial flutter - biventricular heart insufficiency - sick-sinus syndrome - 3. Arterial hypertension. 4. chronic bilateral venous insufficiency]. 61
1815311 1991
10
[Mitral annulus calcification: clinical observation on 72 patients]. 61
1677408 1991
11
[Experience with dual-chamber pacemakers at the Valencia General Hospital]. 61
2236803 1990
12
[Permanent atrial pacemaker implantation in children with sick sinus syndrome--3 clinical experience (author's transl)]. 61
7462733 1980

Variations for Sick Sinus Syndrome 3

ClinVar genetic disease variations for Sick Sinus Syndrome 3:

6 (show all 12)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MYH6 NM_002471.3(MYH6):c.2161C>T (p.Arg721Trp) SNV risk factor 29799 rs387906656 GRCh37: 14:23866179-23866179
GRCh38: 14:23396970-23396970
2 MYH6 NM_002471.4(MYH6):c.3508G>A (p.Glu1170Lys) SNV Uncertain significance 164230 rs727503236 GRCh37: 14:23859490-23859490
GRCh38: 14:23390281-23390281
3 MYH6 NM_002471.3(MYH6):c.5135G>T (p.Ser1712Ile) SNV Uncertain significance 191709 rs201383498 GRCh37: 14:23855165-23855165
GRCh38: 14:23385956-23385956
4 MYH6 NM_002471.3(MYH6):c.5077G>A (p.Val1693Met) SNV Uncertain significance 373555 rs373457153 GRCh37: 14:23855223-23855223
GRCh38: 14:23386014-23386014
5 MYH6 NM_002471.3(MYH6):c.3604G>A (p.Val1202Met) SNV Uncertain significance 312860 rs368451573 GRCh37: 14:23859394-23859394
GRCh38: 14:23390185-23390185
6 MYH6 NM_002471.4(MYH6):c.2611C>T (p.Arg871Cys) SNV Uncertain significance 44469 rs376682837 GRCh37: 14:23863351-23863351
GRCh38: 14:23394142-23394142
7 MYH6 NM_002471.3(MYH6):c.2576G>C (p.Gly859Ala) SNV Uncertain significance 537946 rs779528748 GRCh37: 14:23863386-23863386
GRCh38: 14:23394177-23394177
8 MYH6 NM_002471.3(MYH6):c.1521T>G (p.Ile507Met) SNV Uncertain significance 432873 rs142410102 GRCh37: 14:23869525-23869525
GRCh38: 14:23400316-23400316
9 MYH6 NM_002471.3(MYH6):c.1244G>C (p.Gly415Ala) SNV Uncertain significance 239163 rs759520932 GRCh37: 14:23870084-23870084
GRCh38: 14:23400875-23400875
10 LOC114827851 , MYH6 NM_002471.4(MYH6):c.292G>A (p.Glu98Lys) SNV Uncertain significance 44474 rs140596256 GRCh37: 14:23874889-23874889
GRCh38: 14:23405680-23405680
11 LOC114827851 , MYH6 NM_002471.3(MYH6):c.115G>A (p.Val39Met) SNV Uncertain significance 191724 rs142850511 GRCh37: 14:23876318-23876318
GRCh38: 14:23407109-23407109
12 MYH6 NM_002471.4(MYH6):c.4505G>A (p.Arg1502Gln) SNV Uncertain significance 44513 rs199936506 GRCh37: 14:23856987-23856987
GRCh38: 14:23387778-23387778

UniProtKB/Swiss-Prot genetic disease variations for Sick Sinus Syndrome 3:

72
# Symbol AA change Variation ID SNP ID
1 MYH6 p.Arg721Trp VAR_065561 rs387906656

Expression for Sick Sinus Syndrome 3

Search GEO for disease gene expression data for Sick Sinus Syndrome 3.

Pathways for Sick Sinus Syndrome 3

GO Terms for Sick Sinus Syndrome 3

Sources for Sick Sinus Syndrome 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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