MCID: SDR005
MIFTS: 19

Sideroblastic Anemia Acquired

Categories: Rare diseases, Genetic diseases, Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Sideroblastic Anemia Acquired

MalaCards integrated aliases for Sideroblastic Anemia Acquired:

Name: Sideroblastic Anemia Acquired 53 55

Classifications:



Summaries for Sideroblastic Anemia Acquired

MalaCards based summary : Sideroblastic Anemia Acquired is related to sideroblastic anemia and acquired idiopathic sideroblastic anemia. An important gene associated with Sideroblastic Anemia Acquired is ALAS2 (5'-Aminolevulinate Synthase 2), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Related Diseases for Sideroblastic Anemia Acquired

Diseases in the Sideroblastic Anemia family:

Anemia, Sideroblastic, 4 Anemia, Sideroblastic, 1
Autosomal Dominant Sideroblastic Anemia Sideroblastic Anemia Acquired
Autosomal Recessive Sideroblastic Anemia

Diseases related to Sideroblastic Anemia Acquired via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 sideroblastic anemia 29.2 ALAS2 MT-ATP6 MT-CO1
2 acquired idiopathic sideroblastic anemia 11.2
3 periodic paralysis with later-onset distal motor neuropathy 10.2 MT-ATP6 MT-ATP8
4 isolated atp synthase deficiency 10.2 MT-ATP6 MT-ATP8
5 striatonigral degeneration, infantile, mitochondrial 10.2 MT-ATP6 MT-ATP8
6 myopathy, lactic acidosis, and sideroblastic anemia 3 10.1 MT-ATP6 MT-ATP8
7 mitochondrial complex v deficiency 10.1 MT-ATP6 MT-ATP8
8 striatonigral degeneration, infantile 10.1 MT-ATP6 MT-ATP8
9 ataxia and polyneuropathy, adult-onset 10.1 MT-ATP6 MT-ATP8
10 myopathy, lactic acidosis, and sideroblastic anemia 10.1 MT-ATP6 MT-ATP8
11 cystic echinococcosis 9.9 MT-ATP6 MT-CO1
12 cercarial dermatitis 9.9 MT-ATP8 MT-CO1
13 echinococcosis 9.9 MT-ATP6 MT-CO1
14 diphyllobothriasis 9.8 MT-ATP8 MT-CO1
15 pearson marrow-pancreas syndrome 9.7 ALAS2 MT-CO2
16 myoglobinuria, recurrent 9.6 MT-CO1 MT-CO2
17 parasitic protozoa infectious disease 9.4 MT-CO1 MT-CO2
18 mitochondrial encephalomyopathy 9.4 MT-CO1 MT-CO2
19 mitochondrial complex iv deficiency 9.3 MT-CO1 MT-CO2
20 mitochondrial disorders 9.3 MT-ATP6 MT-CO2
21 leber hereditary optic neuropathy 9.3 MT-ATP6 MT-CO1
22 cardiomyopathy, infantile hypertrophic 9.2 MT-ATP6 MT-ATP8 MT-CO2
23 mitochondrial dna depletion syndrome 1 9.2 MT-ATP6 MT-ATP8 MT-CO2
24 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 9.1 MT-ATP6 MT-CO1 MT-CO2
25 myopathy 8.7 MT-ATP6 MT-CO1 MT-CO2
26 deafness, nonsyndromic sensorineural, mitochondrial 8.5 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2
27 leber optic atrophy 8.5 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2
28 familial colorectal cancer 8.5 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2
29 kearns-sayre syndrome 8.5 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2
30 mitochondrial myopathy 8.5 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2
31 leigh syndrome 8.5 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2

Graphical network of the top 20 diseases related to Sideroblastic Anemia Acquired:



Diseases related to Sideroblastic Anemia Acquired

Symptoms & Phenotypes for Sideroblastic Anemia Acquired

Drugs & Therapeutics for Sideroblastic Anemia Acquired

Search Clinical Trials , NIH Clinical Center for Sideroblastic Anemia Acquired

Genetic Tests for Sideroblastic Anemia Acquired

Anatomical Context for Sideroblastic Anemia Acquired

Publications for Sideroblastic Anemia Acquired

Variations for Sideroblastic Anemia Acquired

Expression for Sideroblastic Anemia Acquired

Search GEO for disease gene expression data for Sideroblastic Anemia Acquired.

Pathways for Sideroblastic Anemia Acquired

GO Terms for Sideroblastic Anemia Acquired

Cellular components related to Sideroblastic Anemia Acquired according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.71 ALAS2 MT-ATP8 MT-CO1 MT-CO2
2 respiratory chain GO:0070469 9.37 MT-CO1 MT-CO2
3 mitochondrial proton-transporting ATP synthase complex GO:0005753 9.32 MT-ATP6 MT-ATP8
4 mitochondrial respiratory chain complex IV GO:0005751 9.26 MT-CO1 MT-CO2
5 proton-transporting ATP synthase complex, coupling factor F(o) GO:0045263 9.16 MT-ATP6 MT-ATP8
6 mitochondrial inner membrane GO:0005743 9.02 ALAS2 MT-ATP6 MT-ATP8 MT-CO1 MT-CO2
7 respiratory chain complex IV GO:0045277 8.96 MT-CO1 MT-CO2

Biological processes related to Sideroblastic Anemia Acquired according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.43 MT-ATP6 MT-CO1
2 proton transmembrane transport GO:1902600 9.4 MT-CO1 MT-CO2
3 electron transport chain GO:0022900 9.37 MT-CO1 MT-CO2
4 ATP biosynthetic process GO:0006754 9.32 MT-ATP6 MT-ATP8
5 cristae formation GO:0042407 9.26 MT-ATP6 MT-ATP8
6 ATP synthesis coupled proton transport GO:0015986 9.16 MT-ATP6 MT-ATP8
7 mitochondrial electron transport, cytochrome c to oxygen GO:0006123 8.96 MT-CO1 MT-CO2
8 mitochondrial ATP synthesis coupled proton transport GO:0042776 8.62 MT-ATP6 MT-ATP8

Molecular functions related to Sideroblastic Anemia Acquired according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.16 MT-ATP6 MT-ATP8
2 proton transmembrane transporter activity GO:0015078 8.96 MT-ATP6 MT-ATP8
3 cytochrome-c oxidase activity GO:0004129 8.62 MT-CO1 MT-CO2

Sources for Sideroblastic Anemia Acquired

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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