MCID: SDR002
MIFTS: 46

Siderosis

Categories: Eye diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Siderosis

MalaCards integrated aliases for Siderosis:

Name: Siderosis 12 76 53 55 44 15 73
Pulmonary Siderosis 12
Deposition of Iron 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10328
ICD10 33 J63.4
MeSH 44 D012806
SNOMED-CT 68 62371005

Summaries for Siderosis

MalaCards based summary : Siderosis, also known as pulmonary siderosis, is related to superficial siderosis of the central nervous system and superficial siderosis. An important gene associated with Siderosis is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Vesicle-mediated transport. The drugs Iron and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotype is liver/biliary system.

Wikipedia : 76 Siderosis is the deposition of excess iron in body tissue. When used without qualification, it usually... more...

Related Diseases for Siderosis

Diseases in the Siderosis family:

Siderosis of Eye

Diseases related to Siderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 superficial siderosis of the central nervous system 33.9 FTH1 TF
2 superficial siderosis 33.8 FTH1 HMOX1 TF
3 iron overload in africa 32.6 TFRC TF SLC40A1 HFE HBB
4 hemosiderosis 30.3 TFRC TF SLC40A1 HFE
5 thalassemia 30.3 HBB HFE TF TFRC
6 porphyria 30.2 HFE TF UROD
7 porphyria cutanea tarda 29.9 HFE TF TFRC UROD
8 beta-thalassemia 29.9 HBB HFE TF TFRC
9 porphyria cutanea tarda, type i 29.9 HFE UROD
10 liver disease 29.7 HFE SERPINA1 TF
11 liver cirrhosis 29.6 HFE SERPINA1 TF
12 hemochromatosis, type 1 28.5 UROD TFRC TF SLC40A1 SERPINA1 HFE
13 siderosis of eye 12.1
14 hemochromatosis, neonatal 11.4
15 interstitial lung disease 11.4
16 cerebral amyloid angiopathy, cst3-related 10.4
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
18 hyperferritinemia with or without cataract 10.2 HFE TF
19 sensorineural hearing loss 10.2
20 ependymoma 10.2
21 familial porphyria cutanea tarda 10.2 HFE UROD
22 hemochromatosis, type 3 10.2 HFE SLC40A1
23 folic acid deficiency anemia 10.2 TF TFRC
24 microcytic anemia 10.2 TF TFRC
25 hypochromic microcytic anemia 10.1 HBB TF
26 hepatitis 10.1
27 acute porphyria 10.1 HFE UROD
28 angiomatous meningioma 10.1 TF TFRC
29 porphyria variegata 10.1 HFE UROD
30 rhizomelic chondrodysplasia punctata, type 2 10.1 HFE UROD
31 cardiomyopathy, familial hypertrophic, 9 10.1 FTH1 TF
32 hemochromatosis, type 5 10.1 FTH1 HFE
33 hemochromatosis, type 4 10.1 HFE SLC40A1 TF
34 hemochromatosis type 2 10.1 HFE SLC40A1 TF
35 intracranial hypotension 10.1
36 headache 10.1
37 anemia, sideroblastic, 1 10.0 HBB TFRC
38 hemoglobinopathy 10.0 HBB HFE TF
39 acute chest syndrome 10.0 HBB HMOX1
40 osteoporosis 10.0
41 hydrocephalus 10.0
42 meningeal melanocytoma 10.0
43 cavernous malformation 10.0
44 spontaneous intracranial hypotension 10.0
45 hemoglobin h disease 10.0 HBB TF TFRC
46 congenital disorder of glycosylation, type iii 10.0 SERPINA1 TF
47 ancylostomiasis 10.0 SERPINA1 TF
48 hereditary spherocytosis 10.0 HBB HFE TFRC
49 retinitis pigmentosa 7 10.0 SERPINA1 TF
50 alzheimer disease 10.0

Graphical network of the top 20 diseases related to Siderosis:



Diseases related to Siderosis

Symptoms & Phenotypes for Siderosis

MGI Mouse Phenotypes related to Siderosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 FTH1 HFE HMOX1 SLC40A1 TFRC UROD

Drugs & Therapeutics for Siderosis

Drugs for Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3,Not Applicable 7439-89-6 23925
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3
Deferasirox Approved, Investigational Phase 4,Phase 2,Phase 3 201530-41-8 5493381
4 Liver Extracts Phase 4,Not Applicable
5 Trace Elements Phase 4,Not Applicable
6 Micronutrients Phase 4,Not Applicable
7 Interferon-beta Phase 4
8 Antiviral Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Immunologic Factors Phase 4
11 Adjuvants, Immunologic Phase 4
12 interferons Phase 4
13 Iron Chelating Agents Phase 4,Phase 2,Phase 3
14 Chelating Agents Phase 4,Phase 2,Phase 3
15
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
16
Deferoxamine Approved, Investigational Phase 2, Phase 3 70-51-9 2973
17
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
18
Epigallocatechin Experimental, Investigational Phase 3 970-74-1 72277
19
Epigallocatechin gallate Investigational Phase 3 989-51-5 65064
20 Protective Agents Phase 3,Phase 2
21 Antihypertensive Agents Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3,Phase 1
23 calcium channel blockers Phase 2, Phase 3
24 Vasodilator Agents Phase 2, Phase 3
25 Antioxidants Phase 3
26 Neuroprotective Agents Phase 3
27
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
28
Propranolol Approved, Investigational Phase 2 525-66-6 4946
29
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
30 Antimitotic Agents Phase 2
31 Cardiotonic Agents Phase 2
32 razoxane Phase 2
33 Analgesics Phase 2
34 Peripheral Nervous System Agents Phase 2
35 Topoisomerase Inhibitors Phase 2
36 Anticholesteremic Agents Phase 1, Phase 2
37 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
38 Antimetabolites Phase 1, Phase 2,Phase 2
39 Lipid Regulating Agents Phase 1, Phase 2
40 Hypolipidemic Agents Phase 1, Phase 2
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
42 Adrenergic beta-Antagonists Phase 2
43 Adrenergic Antagonists Phase 2
44 Neurotransmitter Agents Phase 2
45 Adrenergic Agents Phase 2
46 Anti-Arrhythmia Agents Phase 2
47 Pharmaceutical Solutions Phase 2
48 Antimetabolites, Antineoplastic Phase 2
49
Pancrelipase Approved, Investigational 53608-75-6
50
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial Completed NCT01085318 Phase 4 Rebif
3 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
4 Amlodipine for Myocardial Iron in Thalassemia Completed NCT02065492 Phase 2, Phase 3 Standard Chelation;Amlodipine
5 Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach Completed NCT02008721 Phase 3 EGCG as putative neuroprotective agent;Placebo
6 Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination Unknown status NCT01627938 Phase 2 Dexrazoxane (DRZ) plus Mitoxantrone (MX);Placebo plus Mitoxantrone (MX)
7 Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
8 Treat_CCM: Propranolol in Cerebral Cavernous Malformation Recruiting NCT03589014 Phase 2 Propranolol
9 Deferiprone for Ruptured Brain Aneurysm Not yet recruiting NCT03754725 Phase 2 Deferiprone pill;placebo
10 Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome Terminated NCT01892644 Phase 2 Deferasirox;Deferasirox
11 Azacitidine Plus Deferasirox (ICL670) in Higher Risk Myelodysplastic Syndromes (MDS) Terminated NCT02038816 Phase 2 Deferasirox + Azacitidine;Azacitidine
12 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
13 Multi-Center Study of Iron Overload: Survey Study (MCSIO) Unknown status NCT01913548
14 Multi-Center Study of Iron Overload: Pilot Study Unknown status NCT01114776
15 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
16 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
17 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
18 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
19 A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months Completed NCT01695434
20 T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients Completed NCT00520559
21 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
22 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
23 Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound Completed NCT02044523
24 Iron Mediated Vascular Disease in Sickle Cell Anemia Patients Completed NCT01239901
25 Magnetic Resonance Imaging Study of Acute Pancreatitis Completed NCT01911689
26 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Recruiting NCT03464344 Not Applicable
27 Reproductive Capacity and Iron Burden in Thalassemia Recruiting NCT02308904 Not Applicable
28 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327
29 Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease Recruiting NCT02800395 Not Applicable
30 Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN Recruiting NCT02940327
31 European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) Recruiting NCT02804789
32 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
33 A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients. Enrolling by invitation NCT01935661
34 Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease Enrolling by invitation NCT02752750
35 Neuroimaging of Donor Iron Deficient Study Enrolling by invitation NCT02990559
36 Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis Not yet recruiting NCT02664571 Not Applicable
37 Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes Terminated NCT02445469 Not Applicable

Search NIH Clinical Center for Siderosis

Cochrane evidence based reviews: siderosis

Genetic Tests for Siderosis

Anatomical Context for Siderosis

MalaCards organs/tissues related to Siderosis:

41
Liver, Lung, Brain, Heart, Bone, Eye, Pituitary

Publications for Siderosis

Articles related to Siderosis:

(show top 50) (show all 671)
# Title Authors Year
1
CT and MR myelography in superficial siderosis. ( 29429117 )
2018
2
The varied presentations of siderosis from retained intraocular foreign body. ( 29923333 )
2018
3
Heavy metal--not just hard on the ears: siderosis following retained intraocular foreign body. ( 29631835 )
2018
4
Bilateral Vestibulopathy in Superficial Siderosis. ( 29928256 )
2018
5
Atrophy patterns in cerebral amyloid angiopathy with and without cortical superficial siderosis. ( 29678935 )
2018
6
Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System. ( 29889788 )
2018
7
Cortical superficial siderosis: A prospective observational cohort study. ( 29884737 )
2018
8
Superficial Siderosis and Dural Ectasia in aA Patient with Marfan Syndrome. ( 29468260 )
2018
9
The mysterious case of bilateral sensory neural hearing loss (superficial siderosis). ( 29766953 )
2018
10
Cortical superficial siderosis and acute convexity subarachnoid hemorrhage in cerebral amyloid angiopathy. ( 29053885 )
2018
11
Letter by Guo et al Regarding Article, "Prevalence and Natural History of Superficial Siderosis: A Population-Based Study". ( 29472280 )
2018
12
Superficial Siderosis Associated with Pineal Cavernous Malformation. ( 29017984 )
2018
13
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
14
Focal cortical superficial siderosis due to hemorrhagic transformation of cortical microinfarction. ( 29732518 )
2018
15
Two-year observational study of deferiprone in superficial siderosis. ( 29285884 )
2018
16
Clinical utility of endocrine markers predicting myocardial siderosis in transfusion dependent thalassemia major. ( 29893484 )
2018
17
Spinal endoscopy combined with selective CT myelography for dural closure of the spinal dural defect with superficial siderosis: technical note. ( 29087811 )
2018
18
Focused Neuro-Otological Review of Superficial Siderosis of the Central Nervous System. ( 29892257 )
2018
19
Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome. ( 30279085 )
2018
20
Letter to the Editor. Epidural blood patch in superficial siderosis caused by spontaneous intracranial hypotension. ( 30485219 )
2018
21
A case of pulmonary siderosis misdiagnosed as pneumonia. ( 30003022 )
2018
22
Clinical Significance of T2*gradient-recalled Echo/susceptibility-weighted Imaging Sequences in Evaluating Superficial Siderosis in the Setting of Intracerebral Tumors: Pilocytic Astrocytoma. ( 30197827 )
2018
23
Superficial siderosis associated with craniopharyngioma: a rare case report. ( 30529527 )
2018
24
An unusual presentation of superficial siderosis with focal dystonia and 'Giant panda morphology' on MRI: atypical clinicoradiological amalgam. ( 30465100 )
2018
25
Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature. ( 29122310 )
2018
26
Superficial siderosis misdiagnosed as idiopathic bilateral neurosensorial deafness. ( 30002205 )
2018
27
Superficial siderosis: Chronic sequelae following brain hemorrhage. ( 30042810 )
2018
28
Superficial Siderosis of Central Nervous System as Primary Clinical Manifestation Secondary to Intradural Thoracic Disk Herniation. ( 30048787 )
2018
29
Superficial siderosis associated with duplicated dura mater detected by CISS reverse MRI. ( 30097152 )
2018
30
Intracranial arterial dolichoectasia and superficial siderosis associated to neurofibromatosis type 1: report of one case. ( 30097749 )
2018
31
Pulmonary siderosis cases diagnosed with minimally invasive surgical technique: A retrospective analysis of 7 cases. ( 30123335 )
2018
32
Superficial Siderosis of the Central Nervous System Due to Recurrent Surgeries of the Thoracic Spine: A Rare Case. ( 30165218 )
2018
33
Updating superficial siderosis of the central nervous system: bleeding of a dorsal osteophyte into the subarachnoid space from a perforating artery. ( 30485230 )
2018
34
Superficial Siderosis of the Central Nervous System: Neurotological Findings Related to Magnetic Resonance Imaging. ( 30516591 )
2018
35
Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. ( 28580859 )
2017
36
Rare association of secondary superficial siderosis caused by a fourth ventricle hemorrhagic ependymoma mimicking a cavernoma: Case report and literature review. ( 28217393 )
2017
37
Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis. ( 28089561 )
2017
38
Prevalence and clinical characteristics of cortical superficial siderosis in patients with acute stroke. ( 29063241 )
2017
39
Ischemic lesions and superficial siderosis in CAA: Partners in crime or innocent bystanders? ( 29070660 )
2017
40
Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder. ( 28226077 )
2017
41
Teaching NeuroImages: Superficial siderosis due to a dural cervical arteriovenous fistula. ( 28220016 )
2017
42
Stroke: Cortical superficial siderosis absent in CADASIL. ( 28452354 )
2017
43
A case of superficial siderosis ameliorated after closure of dural deficit detected by MRI-CISS (constructive interference in steady state) imaging. ( 28367945 )
2017
44
Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: A prospective study. ( 29070669 )
2017
45
Superficial Siderosis Associated with a Spinal Dural Defect. ( 28978812 )
2017
46
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. ( 28356458 )
2017
47
Sepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosis. ( 28052950 )
2017
48
Erratum: Rare association of secondary superficial siderosis caused by a fourth ventricle hemorrhagic ependymoma mimicking a cavernoma: Case report and literature review. ( 28540135 )
2017
49
Case Report: A Comprehensive Neuropsychological Assessment of a Case of Superficial Siderosis. ( 28158476 )
2017
50
Intradural extramedullary cavernous malformation with extensive superficial siderosis of the neuraxis: Case report and review of literature. ( 28680728 )
2017

Variations for Siderosis

Expression for Siderosis

Search GEO for disease gene expression data for Siderosis.

Pathways for Siderosis

Pathways related to Siderosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 FTH1 HMOX1 SLC40A1 TF TFRC
2
Show member pathways
12.94 FTH1 HBB SERPINA1 TF TFRC
3
Show member pathways
12.1 FTH1 HMOX1 SLC40A1 TF TFRC
4 11.74 FTH1 HMOX1 SERPINA1
5 11.54 HMOX1 TF TFRC
6 11.31 HMOX1 TF TFRC
7 11.28 HMOX1 SERPINA1
8 11.16 FTH1 HMOX1 SLC40A1 TF
9 10.62 FTH1 HMOX1 SLC40A1 TF TFRC
10 10.34 FTH1 SLC40A1 TF TFRC

GO Terms for Siderosis

Cellular components related to Siderosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 HBB HFE HMOX1 SERPINA1 TF TFRC
2 perinuclear region of cytoplasm GO:0048471 9.71 HFE HMOX1 TF TFRC
3 early endosome GO:0005769 9.61 HFE TF TFRC
4 blood microparticle GO:0072562 9.54 HBB TF TFRC
5 clathrin-coated pit GO:0005905 9.49 TF TFRC
6 tertiary granule lumen GO:1904724 9.48 FTH1 HBB
7 clathrin-coated vesicle membrane GO:0030665 9.46 TF TFRC
8 ficolin-1-rich granule lumen GO:1904813 9.33 FTH1 HBB SERPINA1
9 basal part of cell GO:0045178 9.26 HFE TF
10 recycling endosome GO:0055037 9.13 HFE TF TFRC
11 HFE-transferrin receptor complex GO:1990712 8.8 HFE TF TFRC

Biological processes related to Siderosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.54 HBB HMOX1
2 acute-phase response GO:0006953 9.52 HFE SERPINA1
3 liver regeneration GO:0097421 9.51 HFE HMOX1
4 transferrin transport GO:0033572 9.5 HFE TF TFRC
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.49 HFE TF
6 multicellular organismal iron ion homeostasis GO:0060586 9.48 HFE SLC40A1
7 cellular response to iron ion GO:0071281 9.46 HFE TF
8 heme metabolic process GO:0042168 9.43 HMOX1 UROD
9 iron ion import GO:0097286 9.4 FTH1 TFRC
10 regulation of iron ion import GO:1900390 9.37 HFE TF
11 iron ion transport GO:0006826 9.33 FTH1 SLC40A1 TF
12 regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395 9.26 HMOX1 SLC40A1
13 iron ion homeostasis GO:0055072 9.26 HFE HMOX1 SLC40A1 TF
14 cellular iron ion homeostasis GO:0006879 9.17 FTH1 ISCU SLC40A1 TFRC TF HMOX1

Molecular functions related to Siderosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 FTH1 HBB HFE HMOX1 ISCU SERPINA1
2 ferric iron binding GO:0008199 9.16 FTH1 TF
3 transferrin receptor binding GO:1990459 8.96 HFE TF
4 ferrous iron binding GO:0008198 8.8 FTH1 ISCU TF

Sources for Siderosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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