MCID: SDR002
MIFTS: 47

Siderosis

Categories: Rare diseases, Respiratory diseases, Eye diseases

Aliases & Classifications for Siderosis

MalaCards integrated aliases for Siderosis:

Name: Siderosis 12 76 53 55 44 15 73
Pulmonary Siderosis 12
Deposition of Iron 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10328
ICD10 33 J63.4
MeSH 44 D012806

Summaries for Siderosis

MalaCards based summary : Siderosis, also known as pulmonary siderosis, is related to superficial siderosis of the central nervous system and iron overload in africa. An important gene associated with Siderosis is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Vesicle-mediated transport. The drugs Iron and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related phenotype is liver/biliary system.

Wikipedia : 76 Siderosis is the deposition of iron in... more...

Related Diseases for Siderosis

Diseases in the Siderosis family:

Siderosis of Eye

Diseases related to Siderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 superficial siderosis of the central nervous system 34.2 FTH1 TF
2 iron overload in africa 33.8 HFE TF
3 superficial siderosis 33.4 FTH1 HMOX1 TF
4 porphyria cutanea tarda, type i 30.3 HFE UROD
5 porphyria 30.3 HFE TF UROD
6 hemosiderosis 29.8 HFE SLC40A1 TF TFRC
7 thalassemia 29.7 HBB HFE TF TFRC
8 porphyria cutanea tarda 29.5 HFE TF TFRC UROD
9 beta-thalassemia 29.3 HBB HFE TF TFRC
10 liver disease 29.1 HFE SERPINA1 TF
11 liver cirrhosis 29.1 HFE SERPINA1 TF
12 hemochromatosis, type 1 25.2 HBB HFE HMOX1 SERPINA1 SLC40A1 TF
13 siderosis of eye 11.9
14 hemochromatosis, neonatal 11.2
15 interstitial lung disease 11.2
16 hyperferritinemia with or without cataract 10.7 HFE TF
17 familial porphyria cutanea tarda 10.6 HFE UROD
18 hemochromatosis type 2 10.6 HFE SLC40A1
19 acute porphyria 10.6 HFE UROD
20 folic acid deficiency anemia 10.5 TF TFRC
21 porphyria variegata 10.5 HFE UROD
22 angiomatous meningioma 10.5 TF TFRC
23 hypochromic microcytic anemia 10.5 HBB TF
24 rhizomelic chondrodysplasia punctata, type 2 10.5 HFE UROD
25 cardiomyopathy, familial hypertrophic, 9 10.4 FTH1 TF
26 nutritional deficiency disease 10.4 TF TFRC
27 hepatitis 10.3
28 cerebritis 10.3
29 cerebral amyloid angiopathy, cst3-related 10.3
30 hemoglobinopathy 10.2 HBB TF
31 anemia, sideroblastic, 1 10.2 HBB TFRC
32 microcytic anemia 10.2 TF TFRC
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
34 hemoglobin h disease 10.0 HBB TF TFRC
35 congenital hemolytic anemia 10.0 HBB TF
36 sensorineural hearing loss 10.0
37 ependymoma 10.0
38 immune system disease 10.0 HBB TF TFRC
39 ancylostomiasis 10.0 SERPINA1 TF
40 congenital disorder of glycosylation, type ii 10.0 SERPINA1 TF
41 meningitis 10.0
42 epileptic encephalopathy, early infantile, 36 10.0 SERPINA1 TF
43 retinitis pigmentosa 7 10.0 SERPINA1 TF
44 cervicitis 9.9
45 alpha-1-antitrypsin deficiency 9.9 HFE SERPINA1
46 cavernous malformation 9.9
47 testicular yolk sac tumor 9.9 SERPINA1 TF
48 osteoporosis 9.9
49 hydrocephalus 9.9
50 intracranial hypotension 9.9

Graphical network of the top 20 diseases related to Siderosis:



Diseases related to Siderosis

Symptoms & Phenotypes for Siderosis

MGI Mouse Phenotypes related to Siderosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 FTH1 HFE HMOX1 SLC40A1 TFRC UROD

Drugs & Therapeutics for Siderosis

Drugs for Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3,Not Applicable 7439-89-6 23925
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3
Deferasirox Approved, Investigational Phase 4,Phase 2,Phase 3 201530-41-8 5493381
4 Liver Extracts Phase 4,Not Applicable
5 Micronutrients Phase 4,Not Applicable
6 Trace Elements Phase 4,Not Applicable
7 Adjuvants, Immunologic Phase 4
8 Anti-Infective Agents Phase 4
9 Antiviral Agents Phase 4
10 Interferon-beta Phase 4
11 interferons Phase 4
12 Chelating Agents Phase 4,Phase 2,Phase 3
13 Iron Chelating Agents Phase 4,Phase 2,Phase 3
14
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
15
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
16
Deferoxamine Approved, Investigational Phase 2, Phase 3 70-51-9 2973
17
Epigallocatechin gallate Investigational Phase 3 989-51-5 65064
18 Protective Agents Phase 3,Phase 2
19 Antihypertensive Agents Phase 2, Phase 3
20 calcium channel blockers Phase 2, Phase 3
21 Calcium, Dietary Phase 2, Phase 3,Phase 1
22 Vasodilator Agents Phase 2, Phase 3
23 Antioxidants Phase 3
24 Neuroprotective Agents Phase 3
25
Epigallocatechin Experimental, Investigational, Nutraceutical Phase 3 970-74-1 72277
26
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
27
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
28 Analgesics Phase 2
29 Antimitotic Agents Phase 2
30 Peripheral Nervous System Agents Phase 2
31 razoxane Phase 2
32 Topoisomerase Inhibitors Phase 2
33 Anticholesteremic Agents Phase 1, Phase 2
34 Antimetabolites Phase 1, Phase 2,Phase 2
35 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
36 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
37 Hypolipidemic Agents Phase 1, Phase 2
38 Lipid Regulating Agents Phase 1, Phase 2
39 Pharmaceutical Solutions Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41
Glatiramer Acetate Approved, Investigational 147245-92-9 3081884
42
Pancrelipase Approved, Investigational 53608-75-6
43
Estradiol Approved, Investigational, Vet_approved Not Applicable 50-28-2 5757
44 Estradiol valerate Approved, Investigational, Vet_approved Not Applicable 979-32-8
45
Polyestradiol phosphate Approved Not Applicable 28014-46-2
46
Testosterone Approved, Investigational Not Applicable 58-22-0 6013
47
Tocopherol Approved, Investigational, Nutraceutical Not Applicable 1406-66-2 14986
48
Vitamin E Approved, Nutraceutical, Vet_approved Not Applicable 59-02-9 14985
49 Antirheumatic Agents
50 Immunosuppressive Agents

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial Completed NCT01085318 Phase 4 Rebif
3 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
4 Amlodipine for Myocardial Iron in Thalassemia Completed NCT02065492 Phase 2, Phase 3 Standard Chelation;Amlodipine
5 Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach Completed NCT02008721 Phase 3 EGCG as putative neuroprotective agent;Placebo
6 Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination Unknown status NCT01627938 Phase 2 Dexrazoxane (DRZ) plus Mitoxantrone (MX);Placebo plus Mitoxantrone (MX)
7 Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Not yet recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
8 Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome Terminated NCT01892644 Phase 2 Deferasirox;Deferasirox
9 Azacitidine Plus Deferasirox (ICL670) in Higher Risk Myelodysplastic Syndromes (MDS) Terminated NCT02038816 Phase 2 Deferasirox + Azacitidine;Azacitidine
10 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
11 Multi-Center Study of Iron Overload: Survey Study (MCSIO) Unknown status NCT01913548
12 Multi-Center Study of Iron Overload: Pilot Study Unknown status NCT01114776
13 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
14 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
15 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
16 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
17 A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months Completed NCT01695434
18 T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients Completed NCT00520559
19 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
20 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
21 Magnetic Resonance Imaging Study of Acute Pancreatitis Completed NCT01911689
22 Reproductive Capacity and Iron Burden in Thalassemia Recruiting NCT02308904 Not Applicable
23 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327
24 Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound Recruiting NCT02044523
25 Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease Recruiting NCT02800395 Not Applicable
26 Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN Recruiting NCT02940327
27 European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) Recruiting NCT02804789
28 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
29 Iron Mediated Vascular Disease in Sickle Cell Anemia Patients Active, not recruiting NCT01239901
30 A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients. Enrolling by invitation NCT01935661
31 Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease Enrolling by invitation NCT02752750
32 Neuroimaging of Donor Iron Deficient Study Enrolling by invitation NCT02990559
33 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Not yet recruiting NCT03464344 Not Applicable
34 Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis Not yet recruiting NCT02664571 Not Applicable
35 Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes Terminated NCT02445469 Not Applicable

Search NIH Clinical Center for Siderosis

Cochrane evidence based reviews: siderosis

Genetic Tests for Siderosis

Anatomical Context for Siderosis

MalaCards organs/tissues related to Siderosis:

41
Liver, Brain, Heart, Lung, Pancreas, Bone, Pituitary

Publications for Siderosis

Articles related to Siderosis:

(show top 50) (show all 630)
# Title Authors Year
1
Clinical utility of endocrine markers predicting myocardial siderosis in transfusion dependent thalassemia major. ( 29893484 )
2018
2
CT and MR myelography in superficial siderosis. ( 29429117 )
2018
3
Two-year observational study of deferiprone in superficial siderosis. ( 29285884 )
2018
4
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
5
Superficial Siderosis Associated with Pineal Cavernous Malformation. ( 29017984 )
2018
6
Focal cortical superficial siderosis due to hemorrhagic transformation of cortical microinfarction. ( 29732518 )
2018
7
The varied presentations of siderosis from retained intraocular foreign body. ( 29923333 )
2018
8
Letter by Guo et al Regarding Article, "Prevalence and Natural History of Superficial Siderosis: A Population-Based Study". ( 29472280 )
2018
9
Cortical superficial siderosis and acute convexity subarachnoid hemorrhage in cerebral amyloid angiopathy. ( 29053885 )
2018
10
The mysterious case of bilateral sensory neural hearing loss (superficial siderosis). ( 29766953 )
2018
11
Superficial Siderosis and Dural Ectasia in aA Patient with Marfan Syndrome. ( 29468260 )
2018
12
Cortical superficial siderosis: A prospective observational cohort study. ( 29884737 )
2018
13
Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System. ( 29889788 )
2018
14
Heavy metal--not just hard on the ears: siderosis following retained intraocular foreign body. ( 29631835 )
2018
15
Bilateral Vestibulopathy in Superficial Siderosis. ( 29928256 )
2018
16
Spinal endoscopy combined with selective CT myelography for dural closure of the spinal dural defect with superficial siderosis: technical note. ( 29087811 )
2018
17
Atrophy patterns in cerebral amyloid angiopathy with and without cortical superficial siderosis. ( 29678935 )
2018
18
Focused Neuro-Otological Review of Superficial Siderosis of the Central Nervous System. ( 29892257 )
2018
19
Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature. ( 29122310 )
2018
20
Acute convexity subarachnoid haemorrhage and cortical superficial siderosis in probable cerebral amyloid angiopathy without lobar haemorrhage. ( 29054916 )
2017
21
Superficial siderosis of central nervous system with unknown cause: report of 2 cases and review of the literature. ( 29160113 )
2017
22
Diagnosis and quantification of fibrosis, steatosis, and hepatic siderosis through multiparametric magnetic resonance imaging. ( 28089429 )
2017
23
Cortical Superficial Siderosis in Different Types of Cerebral Small Vessel Disease. ( 28364025 )
2017
24
Intradural extramedullary cavernous malformation with extensive superficial siderosis of the neuraxis: Case report and review of literature. ( 28680728 )
2017
25
Case Report: A Comprehensive Neuropsychological Assessment of a Case of Superficial Siderosis. ( 28158476 )
2017
26
Superficial siderosis presenting as chronic migraine: Rare presentation of a rare disease. ( 28298848 )
2017
27
Aneurysmal wall imaging in a case of cortical superficial siderosis and multiple unruptured aneurysms. ( 28559509 )
2017
28
Spinal meningeal diverticula, spontaneous intracranial hypotension, and superficial siderosis. ( 28130464 )
2017
29
Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. ( 28580859 )
2017
30
Sepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosis. ( 28052950 )
2017
31
Erratum: Rare association of secondary superficial siderosis caused by a fourth ventricle hemorrhagic ependymoma mimicking a cavernoma: Case report and literature review. ( 28540135 )
2017
32
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. ( 28356458 )
2017
33
Superficial Siderosis Associated with a Spinal Dural Defect. ( 28978812 )
2017
34
Rare association of secondary superficial siderosis caused by a fourth ventricle hemorrhagic ependymoma mimicking a cavernoma: Case report and literature review. ( 28217393 )
2017
35
Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis. ( 28089561 )
2017
36
Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: A prospective study. ( 29070669 )
2017
37
Prevalence and clinical characteristics of cortical superficial siderosis in patients with acute stroke. ( 29063241 )
2017
38
Ischemic lesions and superficial siderosis in CAA: Partners in crime or innocent bystanders? ( 29070660 )
2017
39
A case of superficial siderosis ameliorated after closure of dural deficit detected by MRI-CISS (constructive interference in steady state) imaging. ( 28367945 )
2017
40
Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder. ( 28226077 )
2017
41
Teaching NeuroImages: Superficial siderosis due to a dural cervical arteriovenous fistula. ( 28220016 )
2017
42
Stroke: Cortical superficial siderosis absent in CADASIL. ( 28452354 )
2017
43
Prevalence and Natural History of Superficial Siderosis: A Population-Based Study. ( 29070715 )
2017
44
Superficial siderosis of the central nervous system associated with intraspinal hemorrhage from ventral thoracic epidural veins and a ventral spinal CSF leak: case report. ( 28338451 )
2017
45
Recurrent Focal Neurological Symptoms and Cortical Siderosis. ( 28400907 )
2017
46
Spinal subarachnoid hemorrhage in cortical superficial siderosis after apixaban and clopidogrel therapy. ( 26837378 )
2016
47
Infratentorial superficial siderosis: Classification, diagnostic criteria and rational investigation pathway. ( 28019651 )
2016
48
Superficial Siderosis. ( 27685823 )
2016
49
Aneurysmal wall imaging in a case of cortical superficial siderosis and multiple unruptured aneurysms. ( 27873743 )
2016
50
Familial amyloid polyneuropathy involving a homozygous Val30Met mutation in the amyloidogenic transthyretin gene presenting with superficial siderosis: a case report. ( 27212678 )
2016

Variations for Siderosis

Expression for Siderosis

Search GEO for disease gene expression data for Siderosis.

Pathways for Siderosis

Pathways related to Siderosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 FTH1 HMOX1 SLC40A1 TF TFRC
2
Show member pathways
12.94 FTH1 HBB SERPINA1 TF TFRC
3
Show member pathways
12.1 FTH1 HMOX1 SLC40A1 TF TFRC
4 11.74 FTH1 HMOX1 SERPINA1
5 11.54 HMOX1 TF TFRC
6 11.31 HMOX1 TF TFRC
7 11.16 FTH1 HMOX1 SLC40A1 TF
8 10.62 FTH1 HMOX1 SLC40A1 TF TFRC
9 10.34 FTH1 SLC40A1 TF TFRC

GO Terms for Siderosis

Cellular components related to Siderosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 HBB HFE HMOX1 SERPINA1 TF TFRC
2 perinuclear region of cytoplasm GO:0048471 9.71 HFE HMOX1 TF TFRC
3 early endosome GO:0005769 9.61 HFE TF TFRC
4 blood microparticle GO:0072562 9.54 HBB TF TFRC
5 clathrin-coated pit GO:0005905 9.49 TF TFRC
6 tertiary granule lumen GO:1904724 9.48 FTH1 HBB
7 clathrin-coated vesicle membrane GO:0030665 9.46 TF TFRC
8 ficolin-1-rich granule lumen GO:1904813 9.43 FTH1 HBB SERPINA1
9 recycling endosome GO:0055037 9.33 HFE TF TFRC
10 basal part of cell GO:0045178 8.96 HFE TF
11 HFE-transferrin receptor complex GO:1990712 8.8 HFE TF TFRC

Biological processes related to Siderosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.54 HBB HMOX1
2 acute-phase response GO:0006953 9.52 HFE SERPINA1
3 liver regeneration GO:0097421 9.51 HFE HMOX1
4 transferrin transport GO:0033572 9.5 HFE TF TFRC
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.49 HFE TF
6 multicellular organismal iron ion homeostasis GO:0060586 9.48 HFE SLC40A1
7 cellular response to iron ion GO:0071281 9.46 HFE TF
8 heme metabolic process GO:0042168 9.43 HMOX1 UROD
9 iron ion import GO:0097286 9.4 FTH1 TFRC
10 regulation of iron ion import GO:1900390 9.37 HFE TF
11 iron ion transport GO:0006826 9.33 FTH1 SLC40A1 TF
12 regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395 9.26 HMOX1 SLC40A1
13 iron ion homeostasis GO:0055072 9.26 HFE HMOX1 SLC40A1 TF
14 cellular iron ion homeostasis GO:0006879 9.17 FTH1 HFE HMOX1 ISCU SLC40A1 TF

Molecular functions related to Siderosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.33 FTH1 HBB ISCU
2 ferrous iron binding GO:0008198 9.26 ISCU TF
3 ferric iron binding GO:0008199 8.96 FTH1 TF
4 transferrin receptor binding GO:1990459 8.62 HFE TF
5 protein binding GO:0005515 10.02 FTH1 HBB HFE HMOX1 ISCU SERPINA1

Sources for Siderosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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