MCID: SDR002
MIFTS: 46

Siderosis

Categories: Eye diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Siderosis

MalaCards integrated aliases for Siderosis:

Name: Siderosis 12 77 54 56 45 15 74
Pulmonary Siderosis 12
Deposition of Iron 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10328
MeSH 45 D012806
SNOMED-CT 69 62371005
ICD10 34 J63.4

Summaries for Siderosis

MalaCards based summary : Siderosis, also known as pulmonary siderosis, is related to superficial siderosis and superficial siderosis of the central nervous system. An important gene associated with Siderosis is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Insulin receptor recycling and HIF-1-alpha transcription factor network. The drugs Iron and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related phenotype is liver/biliary system.

Wikipedia : 77 Siderosis is the deposition of excess iron in body tissue. When used without qualification, it usually... more...

Related Diseases for Siderosis

Diseases in the Siderosis family:

Siderosis of Eye

Diseases related to Siderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 superficial siderosis 33.9 FTH1 LTF TF
2 superficial siderosis of the central nervous system 33.7 FTH1 LTF TF
3 iron overload in africa 32.9 HFE SLC40A1 TF TFRC
4 thalassemia 30.6 HFE TF TFRC
5 porphyria 30.4 HFE TF UROD
6 beta-thalassemia 30.2 HFE TF TFRC
7 porphyria cutanea tarda, type i 30.1 HFE UROD
8 porphyria cutanea tarda 29.9 HFE TF TFRC UROD
9 hemosiderosis 29.8 GPT HFE SLC40A1 TF TFRC
10 liver disease 29.4 GPT HFE SERPINA1 TF
11 viral hepatitis 29.2 GPT HFE SERPINA1
12 liver cirrhosis 29.2 GPT HFE SERPINA1 TF
13 hemochromatosis, type 1 29.1 FTH1 HFE SERPINA1 SLC40A1 TF TFRC
14 siderosis of eye 12.1
15 hemochromatosis, neonatal 11.4
16 interstitial lung disease 11.4
17 cerebral amyloid angiopathy, cst3-related 10.5
18 juvenile hereditary hemochromatosis 10.4
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
20 hyperferritinemia with or without cataract 10.3 HFE TF
21 familial porphyria cutanea tarda 10.3 HFE UROD
22 hemochromatosis, type 3 10.3 HFE SLC40A1
23 folic acid deficiency anemia 10.3 TF TFRC
24 acute porphyria 10.2 HFE UROD
25 porphyria variegata 10.2 HFE UROD
26 cardiomyopathy, familial hypertrophic, 9 10.2 FTH1 TF
27 angiomatous meningioma 10.2 TF TFRC
28 hemochromatosis, type 5 10.2 FTH1 HFE
29 sensorineural hearing loss 10.2
30 benign ependymoma 10.2
31 ependymoma 10.2
32 rhizomelic chondrodysplasia punctata, type 2 10.2 HFE UROD
33 kwashiorkor 10.2 GPT TF
34 haemophilus influenzae 10.2 LTF TF
35 radiation proctitis 10.2 LTF TF
36 hepatitis 10.2
37 nonalcoholic steatohepatitis 10.2 GPT HFE
38 analbuminemia 10.1 GPT TF
39 vitamin b12 deficiency 10.1 GPT TF
40 hemochromatosis, type 4 10.1 HFE SLC40A1 TF
41 hemochromatosis type 2 10.1 HFE SLC40A1 TF
42 dysentery 10.1 LTF TF
43 protein-energy malnutrition 10.1 GPT TF
44 hemoglobin h disease 10.1 TF TFRC
45 intracranial hypotension 10.1
46 headache 10.1
47 hemoglobinopathy 10.1 HFE TF
48 osteoporosis 10.0
49 hydrocephalus 10.0
50 meningeal melanocytoma 10.0

Graphical network of the top 20 diseases related to Siderosis:



Diseases related to Siderosis

Symptoms & Phenotypes for Siderosis

MGI Mouse Phenotypes related to Siderosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 FTH1 HFE LTF SLC40A1 TFRC UROD

Drugs & Therapeutics for Siderosis

Drugs for Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 4,Phase 2,Phase 3,Not Applicable 7439-89-6, 15438-31-0 27284 23925
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3
Deferasirox Approved, Investigational Phase 4,Phase 2,Phase 3 201530-41-8 5493381
4 Liver Extracts Phase 4,Not Applicable
5 Nutrients Phase 4,Phase 3,Not Applicable
6 Micronutrients Phase 4,Phase 3,Not Applicable
7 Trace Elements Phase 4,Phase 3,Not Applicable
8 Antiviral Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Adjuvants, Immunologic Phase 4
11 Immunologic Factors Phase 4
12 interferons Phase 4
13 Interferon-beta Phase 4
14 Iron Chelating Agents Phase 4,Phase 2,Phase 3
15 Chelating Agents Phase 4,Phase 2,Phase 3
16
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
17
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
18
Deferoxamine Approved, Investigational Phase 2, Phase 3 70-51-9 2973
19
Zinc Approved, Investigational Phase 3 7440-66-6 32051
20
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
21
Epigallocatechin Experimental, Investigational Phase 3 970-74-1 72277
22
Epigallocatechin gallate Investigational Phase 3 989-51-5 65064
23 Protective Agents Phase 3,Phase 2
24 Siderophores Phase 2, Phase 3
25 Calcium, Dietary Phase 2, Phase 3
26 Antihypertensive Agents Phase 2, Phase 3
27 Hormones Phase 2, Phase 3,Not Applicable
28 calcium channel blockers Phase 2, Phase 3
29 Vasodilator Agents Phase 2, Phase 3
30 Antioxidants Phase 3
31 Neuroprotective Agents Phase 3
32
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
33
Atorvastatin Approved Phase 1, Phase 2 134523-00-5 60823
34
Propranolol Approved, Investigational Phase 2 525-66-6 4946
35
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
36 Antimitotic Agents Phase 2
37 razoxane Phase 2
38 Topoisomerase Inhibitors Phase 2
39 Analgesics Phase 2
40 Cardiotonic Agents Phase 2
41 Peripheral Nervous System Agents Phase 2
42 Anticholesteremic Agents Phase 1, Phase 2
43 Antimetabolites Phase 1, Phase 2,Phase 2
44 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
45 Hypolipidemic Agents Phase 1, Phase 2
46 Lipid Regulating Agents Phase 1, Phase 2
47 Neurotransmitter Agents Phase 2
48 Adrenergic Agents Phase 2
49 Anti-Arrhythmia Agents Phase 2
50 Adrenergic beta-Antagonists Phase 2

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial Completed NCT01085318 Phase 4 Rebif
3 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
4 Amlodipine for Myocardial Iron in Thalassemia Completed NCT02065492 Phase 2, Phase 3 Standard Chelation;Amlodipine
5 Zinc Supplementation in Patients With β-Thalassemia Major Complicated With Diabetes Mellitus Completed NCT03851055 Phase 3 Zinc
6 Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach Completed NCT02008721 Phase 3 EGCG as putative neuroprotective agent;Placebo
7 Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination Unknown status NCT01627938 Phase 2 Dexrazoxane (DRZ) plus Mitoxantrone (MX);Placebo plus Mitoxantrone (MX)
8 Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
9 Treat_CCM: Propranolol in Cerebral Cavernous Malformation Recruiting NCT03589014 Phase 2 Propranolol
10 Deferiprone for Ruptured Brain Aneurysm Not yet recruiting NCT03754725 Phase 2 Deferiprone pill;placebo
11 Early and Low Dose Deferasirox (3.5 mg/kg FCT) to Suppress NTBI and LPI as Early Intervention to Prevent Tissue Iron Overload in Lower Risk MDS Not yet recruiting NCT03920657 Phase 2 Deferasirox
12 Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome Terminated NCT01892644 Phase 2 Deferasirox;Deferasirox
13 Azacitidine Plus Deferasirox (ICL670) in Higher Risk Myelodysplastic Syndromes (MDS) Terminated NCT02038816 Phase 2 Deferasirox + Azacitidine;Azacitidine
14 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
15 Multi-Center Study of Iron Overload: Survey Study (MCSIO) Unknown status NCT01913548
16 Multi-Center Study of Iron Overload: Pilot Study Unknown status NCT01114776
17 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
18 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
19 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
20 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
21 A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months Completed NCT01695434
22 T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients Completed NCT00520559
23 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
24 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
25 Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound Completed NCT02044523
26 Iron Mediated Vascular Disease in Sickle Cell Anemia Patients Completed NCT01239901
27 Magnetic Resonance Imaging Study of Acute Pancreatitis Completed NCT01911689
28 Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN Completed NCT02940327
29 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Recruiting NCT03464344 Not Applicable
30 Glucose, Brain and Microbiota Recruiting NCT03889132
31 Reproductive Capacity and Iron Burden in Thalassemia Recruiting NCT02308904 Not Applicable
32 Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major Recruiting NCT03951818
33 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327
34 Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy Recruiting NCT03958643
35 Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease Recruiting NCT02800395 Not Applicable
36 European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) Recruiting NCT02804789
37 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
38 A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients. Enrolling by invitation NCT01935661
39 Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease Enrolling by invitation NCT02752750
40 Neuroimaging of Donor Iron Deficient Study Enrolling by invitation NCT02990559
41 Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis Not yet recruiting NCT02664571 Not Applicable
42 Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes Terminated NCT02445469 Not Applicable

Search NIH Clinical Center for Siderosis

Cochrane evidence based reviews: siderosis

Genetic Tests for Siderosis

Anatomical Context for Siderosis

MalaCards organs/tissues related to Siderosis:

42
Liver, Brain, Heart, Pituitary, Pancreas, Bone, Eye

Publications for Siderosis

Articles related to Siderosis:

(show top 50) (show all 685)
# Title Authors Year
1
Association Between Cortical Superficial Siderosis and Dementia in Patients With Cognitive Impairment: A Meta-Analysis. ( 30761062 )
2019
2
Superficial Siderosis Associated with Craniopharyngioma. ( 30529527 )
2019
3
Extrahepatic Nonreticuloendothelial Siderosis Is Not Specific to Gestational Alloimmune Liver Disease. ( 30722724 )
2019
4
Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome. ( 30279085 )
2019
5
The varied presentations of siderosis from retained intraocular foreign body. ( 29923333 )
2019
6
Superficial siderosis due to filum terminale tumor: An uncommon cause of cranial nerve dysfunction. ( 30656040 )
2019
7
Implications of cortical superficial siderosis in CAA: Superficial relationships. ( 30674588 )
2019
8
Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy. ( 30674596 )
2019
9
An unusual presentation of superficial siderosis with focal dystonia and 'Giant panda morphology' on MRI: atypical clinicoradiological amalgam. ( 30465100 )
2019
10
Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: Large Prospective cohort and preliminary meta-analysis. ( 30785378 )
2019
11
Ten years of iron chelation in a patient with superficial siderosis. ( 30834458 )
2019
12
The Role of Transnasal Endoscopic Surgery in the Treatment of Superficial Siderosis of the Central Nervous System Secondary to Clivus Arachnoidocele: Report of a Successful Case and Literature Review. ( 30862598 )
2019
13
Cortical Superficial Siderosis Evolution. ( 30869563 )
2019
14
Efficacy and safety of deferiprone for the treatment of superficial siderosis: results from a long-term observational study. ( 30903420 )
2019
15
Detection and monitoring of subclinical ocular siderosis using multifocal electroretinogram. ( 31019264 )
2019
16
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis. ( 31105644 )
2019
17
Clinical Significance of T2*gradient-recalled Echo/susceptibility-weighted Imaging Sequences in Evaluating Superficial Siderosis in the Setting of Intracerebral Tumors: Pilocytic Astrocytoma. ( 30197827 )
2018
18
Superficial Siderosis Associated with Pineal Cavernous Malformation. ( 29017984 )
2018
19
Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. ( 28580859 )
2018
20
Superficial Siderosis Associated with a Spinal Dural Defect. ( 28978812 )
2018
21
Cortical superficial siderosis and acute convexity subarachnoid hemorrhage in cerebral amyloid angiopathy. ( 29053885 )
2018
22
Acute convexity subarachnoid haemorrhage and cortical superficial siderosis in probable cerebral amyloid angiopathy without lobar haemorrhage. ( 29054916 )
2018
23
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
24
Superficial Siderosis and Dural Ectasia in a Patient with Marfan Syndrome. ( 29468260 )
2018
25
Spinal endoscopy combined with selective CT myelography for dural closure of the spinal dural defect with superficial siderosis: technical note. ( 29087811 )
2018
26
Idiopathic infratentorial superficial siderosis of the central nervous system: case report and review of literature. ( 29122310 )
2018
27
Two-year observational study of deferiprone in superficial siderosis. ( 29285884 )
2018
28
CT and MR myelography in superficial siderosis. ( 29429117 )
2018
29
Letter by Guo et al Regarding Article, "Prevalence and Natural History of Superficial Siderosis: A Population-Based Study". ( 29472280 )
2018
30
Heavy metal--not just hard on the ears: siderosis following retained intraocular foreign body. ( 29631835 )
2018
31
Atrophy patterns in cerebral amyloid angiopathy with and without cortical superficial siderosis. ( 29678935 )
2018
32
Focal cortical superficial siderosis due to hemorrhagic transformation of cortical microinfarction. ( 29732518 )
2018
33
The mysterious case of bilateral sensory neural hearing loss (superficial siderosis). ( 29766953 )
2018
34
Cortical superficial siderosis: A prospective observational cohort study. ( 29884737 )
2018
35
Vestibular Dysfunction in Patients With Superficial Siderosis of the Central Nervous System. ( 29889788 )
2018
36
Focused Neuro-Otological Review of Superficial Siderosis of the Central Nervous System. ( 29892257 )
2018
37
Clinical utility of endocrine markers predicting myocardial siderosis in transfusion dependent thalassemia major. ( 29893484 )
2018
38
Bilateral Vestibulopathy in Superficial Siderosis. ( 29928256 )
2018
39
Superficial siderosis misdiagnosed as idiopathic bilateral neurosensorial deafness. ( 30002205 )
2018
40
Superficial siderosis: Chronic sequelae following brain hemorrhage. ( 30042810 )
2018
41
Superficial Siderosis of Central Nervous System as Primary Clinical Manifestation Secondary to Intradural Thoracic Disk Herniation. ( 30048787 )
2018
42
Superficial siderosis associated with duplicated dura mater detected by CISS reverse MRI. ( 30097152 )
2018
43
Intracranial arterial dolichoectasia and superficial siderosis associated to neurofibromatosis type 1: report of one case. ( 30097749 )
2018
44
Pulmonary siderosis cases diagnosed with minimally invasive surgical technique: A retrospective analysis of 7 cases. ( 30123335 )
2018
45
Superficial Siderosis of the Central Nervous System Due to Recurrent Surgeries of the Thoracic Spine: A Rare Case. ( 30165218 )
2018
46
Updating superficial siderosis of the central nervous system: bleeding of a dorsal osteophyte into the subarachnoid space from a perforating artery. ( 30485230 )
2018
47
Superficial Siderosis of the Central Nervous System: Neurotological Findings Related to Magnetic Resonance Imaging. ( 30516591 )
2018
48
Acute ischaemic lesions are associated with cortical superficial siderosis in spontaneous intracerebral hemorrhage. ( 30561110 )
2018
49
A case of pulmonary siderosis misdiagnosed as pneumonia. ( 30003022 )
2018
50
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2018

Variations for Siderosis

Expression for Siderosis

Search GEO for disease gene expression data for Siderosis.

Pathways for Siderosis

GO Terms for Siderosis

Cellular components related to Siderosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 FTH1 GPT LTF SERPINA1 TF TFRC
2 extracellular space GO:0005615 9.73 GPT HFE LTF SERPINA1 TF TFRC
3 early endosome GO:0005769 9.54 HFE TF TFRC
4 clathrin-coated pit GO:0005905 9.46 TF TFRC
5 tertiary granule lumen GO:1904724 9.43 FTH1 LTF
6 clathrin-coated vesicle membrane GO:0030665 9.4 TF TFRC
7 basal part of cell GO:0045178 9.16 HFE TF
8 recycling endosome GO:0055037 9.13 HFE TF TFRC
9 HFE-transferrin receptor complex GO:1990712 8.8 HFE TF TFRC

Biological processes related to Siderosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.76 HFE LTF SLC40A1 TF
2 cellular protein metabolic process GO:0044267 9.61 LTF SERPINA1 TF
3 retina homeostasis GO:0001895 9.49 LTF TF
4 acute-phase response GO:0006953 9.48 HFE SERPINA1
5 transferrin transport GO:0033572 9.43 HFE TF TFRC
6 positive regulation of receptor-mediated endocytosis GO:0048260 9.4 HFE TF
7 multicellular organismal iron ion homeostasis GO:0060586 9.37 HFE SLC40A1
8 iron ion transport GO:0006826 9.33 FTH1 SLC40A1 TF
9 cellular response to iron ion GO:0071281 9.32 HFE TF
10 iron ion homeostasis GO:0055072 9.26 HFE LTF SLC40A1 TF
11 cellular iron ion homeostasis GO:0006879 9.1 FTH1 HFE ISCU SLC40A1 TF TFRC

Molecular functions related to Siderosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.43 FTH1 ISCU LTF
2 ferric iron binding GO:0008199 9.16 FTH1 TF
3 transferrin receptor binding GO:1990459 8.96 HFE TF
4 ferrous iron binding GO:0008198 8.8 FTH1 ISCU TF

Sources for Siderosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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