MCID: SGM001
MIFTS: 29

Sigmoid Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Sigmoid Disease

MalaCards integrated aliases for Sigmoid Disease:

Name: Sigmoid Disease 12 15
Sigmoid Diseases 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1897
MeSH 43 D012810
UMLS 71 C0037072

Summaries for Sigmoid Disease

MalaCards based summary : Sigmoid Disease, also known as sigmoid diseases, is related to isthmus cancer and cervical carcinosarcoma. An important gene associated with Sigmoid Disease is HSPBAP1 (HSPB1 Associated Protein 1), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. The drugs Budesonide and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Sigmoid Disease

Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 isthmus cancer 10.3 MAPK8IP2 MAPK8IP1
2 cervical carcinosarcoma 10.3 MAPK8IP2 MAPK8IP1
3 radiation cystitis 10.3 MAPK8IP2 MAPK8IP1
4 laryngotracheitis 10.3 POLI FUCA1
5 lymphocele 10.2 MAPK8IP2 MAPK8IP1
6 cervix small cell carcinoma 10.2 MAPK8IP2 MAPK8IP1
7 papillary squamous carcinoma 10.2 MAPK8IP2 MAPK8IP1
8 benign struma ovarii 10.2 MAPK8IP2 MAPK8IP1
9 vaginal cancer 10.2 MAPK8IP2 MAPK8IP1
10 vaginal discharge 10.0 MAPK8IP2 MAPK8IP1
11 neurosyphilis 9.8 TLR6 TLR1
12 diverticulitis 9.7
13 toxic pneumonitis 9.6 TLR8 TLR6 TLR10
14 chlamydia pneumonia 9.6 TLR6 TLR1
15 bacterial infectious disease 9.5 TLR5 TLR1 NOD2
16 q fever 9.5 TLR10 TLR1 NOD2
17 ocular toxoplasmosis 9.4 TLR5 TLR1 NOD2
18 toxoplasmosis 9.4 TLR5 TLR1 NOD2
19 penile disease 9.4 TLR8 TLR5
20 endometrial disease 9.4 TLR6 TLR10 TLR1
21 tonsillitis 9.4 TLR5 TLR10 TLR1
22 myd88 deficiency 9.3 TLR6 TLR5 TLR1
23 extrinsic cardiomyopathy 9.2 TLR8 TLR5 TLR1
24 otitis media 9.2 TLR8 TLR5 TLR1
25 aicardi-goutieres syndrome 9.1 TLR8 TLR6 TLR5 TLR10
26 melioidosis 9.1 TLR5 TLR10 TLR1 NOD2
27 invasive aspergillosis 9.1 TLR6 TLR5 TLR1 NOD2
28 irak4 deficiency 9.1 TLR6 TLR5 TLR10 TLR1
29 opportunistic mycosis 9.0 TLR6 TLR5 TLR10 TLR1
30 rectal disease 8.9 TLR8 TLR6 TLR5 TLR1
31 salmonellosis 8.9 TLR8 TLR6 TLR5 TLR1
32 aspergillosis 8.7 TLR6 TLR5 TLR10 TLR1 NOD2
33 diabetes mellitus, insulin-dependent 8.6 TLR8 TLR6 TLR5 TLR1
34 parenchymatous neurosyphilis 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
35 scalp dermatosis 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
36 superficial basal cell carcinoma 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
37 anogenital venereal wart 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
38 streptococcus pneumonia 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
39 herpangina 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
40 vaginal disease 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
41 coccidiosis 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
42 bronchiolitis 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
43 parasitic protozoa infectious disease 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
44 autoimmune disease of musculoskeletal system 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
45 bronchial disease 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
46 bone inflammation disease 8.6 TLR8 TLR6 TLR5 TLR10 TLR1
47 immune system disease 8.5 TLR8 TLR6 TLR5 TLR10 TLR1
48 combat disorder 8.3 TLR8 TLR6 TLR5 TLR10 TLR1 ADSL
49 perinatal necrotizing enterocolitis 8.3 TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
50 leprosy 3 8.3 TLR8 TLR6 TLR5 TLR10 TLR1 NOD2

Graphical network of the top 20 diseases related to Sigmoid Disease:



Diseases related to Sigmoid Disease

Symptoms & Phenotypes for Sigmoid Disease

GenomeRNAi Phenotypes related to Sigmoid Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.44 MAPK8IP1
2 Decreased viability GR00221-A-2 9.44 MAPK8IP2
3 Decreased viability GR00221-A-4 9.44 MAPK8IP1
4 Decreased viability GR00301-A 9.44 MAPK8IP1
5 Decreased viability GR00342-S-1 9.44 MAPK8IP2 TLR1
6 Decreased viability GR00342-S-2 9.44 TLR1
7 Decreased viability GR00342-S-3 9.44 MAPK8IP1 MAPK8IP2 TLR1
8 Decreased viability GR00402-S-2 9.44 MAPK8IP1 MAPK8IP2 TLR1

Drugs & Therapeutics for Sigmoid Disease

Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3 51333-22-3 63006 5281004
2 Cola Phase 3
3 Respiratory System Agents Phase 3
4 glucocorticoids Phase 3
5 Anti-Asthmatic Agents Phase 3
6 Hormone Antagonists Phase 3
7 Autonomic Agents Phase 3
8 Bronchodilator Agents Phase 3
9 Hormones Phase 3
10 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
2 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
3 A Phase 3, Open Label, Multicenter Study to Assess the Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Terminated NCT01349673 Phase 3 Budesonide Foam
4 Robotic-assisted Versus Laparoscopic Sigmoid Resection: a Retrospective Chart Review of Benign and Malignant Sigmoid Disease Completed NCT02636673
5 Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak. Completed NCT02662946

Search NIH Clinical Center for Sigmoid Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


mesalamine

Cochrane evidence based reviews: sigmoid diseases

Genetic Tests for Sigmoid Disease

Anatomical Context for Sigmoid Disease

MalaCards organs/tissues related to Sigmoid Disease:

40
Colon

Publications for Sigmoid Disease

Articles related to Sigmoid Disease:

(show all 13)
# Title Authors PMID Year
1
Single-incision versus conventional laparoscopic sigmoid colectomy: a case-matched series. 61
21792717 2012
2
A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood. 61
20725836 2010
3
Long-term quality-of-life after open and laparoscopic sigmoid colectomy. 61
18427335 2008
4
Primary anastomosis after intraoperative colonic lavage vs. Hartmann's procedure in generalized peritonitis complicating diverticular disease of the colon. 61
12910361 2003
5
Intraoperative colonic lavage with primary anastomosis vs. Hartmann's procedure for perforated diverticular disease of the colon: a consecutive study. 61
12063965 2002
6
[An unusual diverticular sigmoid disease]. 61
10617817 1999
7
Smoking may be associated with complications in diverticular disease. 61
10417566 1999
8
Appendicular involvement in perforated sigmoid disease: US and CT findings. 61
10354887 1999
9
Primary anastomosis with transverse colostomy as an alternative to Hartmann's procedure. 61
7749677 1995
10
Level of anastomosis and recurrent colonic diverticulitis. 61
3946763 1986
11
Bladder symptoms due to silent sigmoid disease. 61
5791049 1969
12
[Clinical use of attapulgite by rectal route in the treatment of recto-sigmoid diseases]. 61
4286409 1966
13
[Precancerous ano-recto-sigmoid diseases]. 61
13909671 1961

Variations for Sigmoid Disease

Expression for Sigmoid Disease

Search GEO for disease gene expression data for Sigmoid Disease.

Pathways for Sigmoid Disease

Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 TLR8 TLR6 TLR5 TLR10 TLR1 MAPK8IP2
2
Show member pathways
12.89 TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
3
Show member pathways
12.47 TLR8 TLR6 TLR5 TLR10 TLR1
4
Show member pathways
12.33 TLR8 TLR6 TLR5 TLR10 TLR1
5
Show member pathways
12.14 TLR8 TLR6 TLR5 TLR10 TLR1
6
Show member pathways
12 TLR8 TLR6 TLR5 TLR10 TLR1
7
Show member pathways
11.95 TLR8 TLR6 TLR5 TLR1
8 11.94 TLR6 TLR1 NOD2
9 11.87 TLR8 TLR6 TLR5 TLR10 TLR1
10
Show member pathways
11.67 TLR8 TLR6 TLR5 TLR10 TLR1
11
Show member pathways
11.45 TLR8 TLR6 TLR5 TLR10 TLR1
12 10.95 TLR8 TLR6 TLR5 TLR10 TLR1

GO Terms for Sigmoid Disease

Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
2 inflammatory response GO:0006954 9.77 TLR8 TLR6 TLR5 TLR10 TLR1
3 innate immune response GO:0045087 9.73 TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
4 toll-like receptor signaling pathway GO:0002224 9.55 TLR8 TLR6 TLR5 TLR10 TLR1
5 microglial cell activation GO:0001774 9.54 TLR8 TLR6
6 positive regulation of interleukin-8 production GO:0032757 9.52 TLR5 NOD2
7 positive regulation of endocytosis GO:0045807 9.51 MAPK8IP2 MAPK8IP1
8 positive regulation of stress-activated MAPK cascade GO:0032874 9.49 NOD2 MAPK8IP2
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.48 TLR6 NOD2
10 regulation of JNK cascade GO:0046328 9.46 MAPK8IP2 MAPK8IP1
11 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.43 TLR6 TLR1
12 cell activation GO:0001775 9.4 TLR6 TLR1
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.35 TLR8 TLR6 TLR5 TLR10 TLR1
14 regulation of cytokine secretion GO:0050707 9.02 TLR8 TLR6 TLR5 TLR10 TLR1

Molecular functions related to Sigmoid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.17 UBR1 TLR8 TLR6 TLR5 TLR10 TLR1
2 lipopeptide binding GO:0071723 9.26 TLR6 TLR1
3 MAP-kinase scaffold activity GO:0005078 9.16 MAPK8IP2 MAPK8IP1
4 transmembrane signaling receptor activity GO:0004888 9.02 TLR8 TLR6 TLR5 TLR10 TLR1
5 Toll-like receptor 2 binding GO:0035663 8.96 TLR6 TLR1

Sources for Sigmoid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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