Sigmoid Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Sigmoid Disease

MalaCards integrated aliases for Sigmoid Disease:

Name: Sigmoid Disease ¹² ¹⁵

Sigmoid Diseases ⁴³ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1897

MeSH ⁴³ D012810

UMLS ⁷¹ C0037072

Sources

Summaries for Sigmoid Disease

MalaCards based summary : Sigmoid Disease, also known as sigmoid diseases, is related to isthmus cancer and cervical carcinosarcoma. An important gene associated with Sigmoid Disease is HSPBAP1 (HSPB1 Associated Protein 1), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. The drugs Budesonide and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are Decreased viability and Decreased viability

Sources

Related Diseases for Sigmoid Disease

Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)

#	Related Disease	Score	Top Affiliating Genes
1	isthmus cancer	10.3	MAPK8IP2 MAPK8IP1
2	cervical carcinosarcoma	10.3	MAPK8IP2 MAPK8IP1
3	radiation cystitis	10.3	MAPK8IP2 MAPK8IP1
4	laryngotracheitis	10.3	POLI FUCA1
5	lymphocele	10.2	MAPK8IP2 MAPK8IP1
6	cervix small cell carcinoma	10.2	MAPK8IP2 MAPK8IP1
7	papillary squamous carcinoma	10.2	MAPK8IP2 MAPK8IP1
8	benign struma ovarii	10.2	MAPK8IP2 MAPK8IP1
9	vaginal cancer	10.2	MAPK8IP2 MAPK8IP1
10	vaginal discharge	10.0	MAPK8IP2 MAPK8IP1
11	neurosyphilis	9.8	TLR6 TLR1
12	diverticulitis	9.7
13	toxic pneumonitis	9.6	TLR8 TLR6 TLR10
14	chlamydia pneumonia	9.6	TLR6 TLR1
15	bacterial infectious disease	9.5	TLR5 TLR1 NOD2
16	q fever	9.5	TLR10 TLR1 NOD2
17	ocular toxoplasmosis	9.4	TLR5 TLR1 NOD2
18	toxoplasmosis	9.4	TLR5 TLR1 NOD2
19	penile disease	9.4	TLR8 TLR5
20	endometrial disease	9.4	TLR6 TLR10 TLR1
21	tonsillitis	9.4	TLR5 TLR10 TLR1
22	myd88 deficiency	9.3	TLR6 TLR5 TLR1
23	extrinsic cardiomyopathy	9.2	TLR8 TLR5 TLR1
24	otitis media	9.2	TLR8 TLR5 TLR1
25	aicardi-goutieres syndrome	9.1	TLR8 TLR6 TLR5 TLR10
26	melioidosis	9.1	TLR5 TLR10 TLR1 NOD2
27	invasive aspergillosis	9.1	TLR6 TLR5 TLR1 NOD2
28	irak4 deficiency	9.1	TLR6 TLR5 TLR10 TLR1
29	opportunistic mycosis	9.0	TLR6 TLR5 TLR10 TLR1
30	rectal disease	8.9	TLR8 TLR6 TLR5 TLR1
31	salmonellosis	8.9	TLR8 TLR6 TLR5 TLR1
32	aspergillosis	8.7	TLR6 TLR5 TLR10 TLR1 NOD2
33	diabetes mellitus, insulin-dependent	8.6	TLR8 TLR6 TLR5 TLR1
34	parenchymatous neurosyphilis	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
35	scalp dermatosis	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
36	superficial basal cell carcinoma	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
37	anogenital venereal wart	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
38	streptococcus pneumonia	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
39	herpangina	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
40	vaginal disease	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
41	coccidiosis	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
42	bronchiolitis	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
43	parasitic protozoa infectious disease	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
44	autoimmune disease of musculoskeletal system	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
45	bronchial disease	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
46	bone inflammation disease	8.6	TLR8 TLR6 TLR5 TLR10 TLR1
47	immune system disease	8.5	TLR8 TLR6 TLR5 TLR10 TLR1
48	combat disorder	8.3	TLR8 TLR6 TLR5 TLR10 TLR1 ADSL
49	perinatal necrotizing enterocolitis	8.3	TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
50	leprosy 3	8.3	TLR8 TLR6 TLR5 TLR10 TLR1 NOD2

Graphical network of the top 20 diseases related to Sigmoid Disease:

Sources

Symptoms & Phenotypes for Sigmoid Disease

GenomeRNAi Phenotypes related to Sigmoid Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	9.44	MAPK8IP1
2	Decreased viability	GR00221-A-2	9.44	MAPK8IP2
3	Decreased viability	GR00221-A-4	9.44	MAPK8IP1
4	Decreased viability	GR00301-A	9.44	MAPK8IP1
5	Decreased viability	GR00342-S-1	9.44	MAPK8IP2 TLR1
6	Decreased viability	GR00342-S-2	9.44	TLR1
7	Decreased viability	GR00342-S-3	9.44	MAPK8IP1 MAPK8IP2 TLR1
8	Decreased viability	GR00402-S-2	9.44	MAPK8IP1 MAPK8IP2 TLR1

Sources

Drugs & Therapeutics for Sigmoid Disease

Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Budesonide

Approved

Phase 3

51333-22-3

63006 5281004

Synonyms:

(11b,16a)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde

(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde

(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione

16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

51333-22-3

AC1L1DQE

AC1L1Y6Y

AC1L22VC

AC1MHWI7

AC-4697

B 7777

B7777_SIGMA

Bidien

Bio-0010

BPBio1_000523

BRD-A34299591-001-03-4

BRD-A82238138-001-01-7

BSPBio_000475

BSPBio_002160

Budecort Inhaler

Budenofalk

Budeson

Budesónida

budesonide

Budesonide

Budesonide (JAN/USAN/INN)

Budesonide [USAN:INN:BAN:JAN]

Budesonide Easyhaler

Budesonide MMX

Budesonide, (R)-isomer

Budesonide, (S)-isomer

Budesonido

Budesonido [INN-Spanish]

Budesonidum

Budesonidum [INN-Latin]

Budiair

Budicort

C25H34O6

CCRIS 5230

CHEBI:3207

CHEBI:656601

CHEMBL1370

CID2462

CID3033890

CID40000

CID5281004

CID63006

Cortivent

CPD000058337

D00246

DB01222

Desowen

Dexbudesonide

Dexbudesonide [INN]

DivK1c_000475

EINECS 257-139-7

EINECS 257-160-1

EINECS 257-161-7

Entocort

Entocort EC

Entocort EC (TN)

EU-0100174

Giona Easyhaler

HMS1569H17

HMS1921I22

HMS2094I13

HMS501H17

Horacort

IDI1_000475

Inflammide

KBio1_000475

KBio3_001660

KBioGR_001361

Lopac0_000174

LS-187734

LS-7235

MAP-0010

Micronyl

Miflonide

MLS000028507

MLS001077323

MLS002207112

MolPort-002-529-265

MolPort-003-666-332

MolPort-003-986-909

NCGC00015165-03

NCGC00021318-03

NCGC00021318-06

NCGC00089747-02

NCGC00089747-03

NCGC00089747-04

NCGC00178789-01

NINDS_000475

Noex

Preferid

Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Prestwick_840

Prestwick0_000518

Prestwick1_000518

Prestwick2_000518

Prestwick3_000518

Pulmaxan

Pulmaxan turbohaler

Pulmicort

Pulmicort (TN)

Pulmicort Flexhaler

Pulmicort Nebuamp

Pulmicort Respules

Pulmicort Topinasal

Pulmicort turbuhaler

Pulmicort Turbuhaler

Respules

Rhinocort

Rhinocort alpha

Rhinocort Aqua

Rhinocort Turbuhaler

Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide

Rhinosol

S 1320

S1286_Selleck

S-1320

SAM002699898

SMR000058337

SPBio_000586

SPBio_002396

SPECTRUM1500813

Spectrum2_000623

Spectrum3_000620

Spectrum4_000821

Spectrum5_001738

Spirocort

ST51039033

TL8003397

Tridesilon

UDB

UNII-168L5HT37P

UNII-2HI1006KPH

UNII-Q3OKS62Q6X

Unit dose budesonide

ZINC03938751

ZINC04097286

2

Cola

Phase 3

3

Respiratory System Agents

Phase 3

4

glucocorticoids

Phase 3

5

Anti-Asthmatic Agents

Phase 3

6

Hormone Antagonists

Phase 3

7

Autonomic Agents

Phase 3

8

Bronchodilator Agents

Phase 3

9

Hormones

Phase 3

10

Anti-Inflammatory Agents

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis	Completed	NCT01008423	Phase 3	Budesonide;Placebo
2	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis	Completed	NCT01008410	Phase 3	Budesonide;Placebo
3	A Phase 3, Open Label, Multicenter Study to Assess the Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis	Terminated	NCT01349673	Phase 3	Budesonide Foam
4	Robotic-assisted Versus Laparoscopic Sigmoid Resection: a Retrospective Chart Review of Benign and Malignant Sigmoid Disease	Completed	NCT02636673
5	Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak.	Completed	NCT02662946

Search NIH Clinical Center for Sigmoid Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

mesalamine

Cochrane evidence based reviews: sigmoid diseases

Sources

Genetic Tests for Sigmoid Disease

Sources

Anatomical Context for Sigmoid Disease

MalaCards organs/tissues related to Sigmoid Disease:

⁴⁰

Colon

Sources

Publications for Sigmoid Disease

Articles related to Sigmoid Disease:

(show all 13)

#	Title	Authors	PMID	Year
1	Single-incision versus conventional laparoscopic sigmoid colectomy: a case-matched series. ⁶¹	Ramos-Valadez DI...Haas EM	21792717	2012
2	A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood. ⁶¹	Doodnath R...Puri P	20725836	2010
3	Long-term quality-of-life after open and laparoscopic sigmoid colectomy. ⁶¹	Seitz G...Kreis ME	18427335	2008
4	Primary anastomosis after intraoperative colonic lavage vs. Hartmann's procedure in generalized peritonitis complicating diverticular disease of the colon. ⁶¹	Regenet N...Arnaud JP	12910361	2003
5	Intraoperative colonic lavage with primary anastomosis vs. Hartmann's procedure for perforated diverticular disease of the colon: a consecutive study. ⁶¹	Regenet N...Arnaud JP	12063965	2002
6	[An unusual diverticular sigmoid disease]. ⁶¹	Lorin De La Grandmaison G...Janin A	10617817	1999
7	Smoking may be associated with complications in diverticular disease. ⁶¹	Papagrigoriadis S...Rennie JA	10417566	1999
8	Appendicular involvement in perforated sigmoid disease: US and CT findings. ⁶¹	Ripolles T...Morote V	10354887	1999
9	Primary anastomosis with transverse colostomy as an alternative to Hartmann's procedure. ⁶¹	Maddern GJ...Launois B	7749677	1995
10	Level of anastomosis and recurrent colonic diverticulitis. ⁶¹	Benn PL...Ilstrup DM	3946763	1986
11	Bladder symptoms due to silent sigmoid disease. ⁶¹	Gibson TE	5791049	1969
12	[Clinical use of attapulgite by rectal route in the treatment of recto-sigmoid diseases]. ⁶¹	Heully F...Penin F	4286409	1966
13	[Precancerous ano-recto-sigmoid diseases]. ⁶¹	SCHWARTZ A...MATELUNA E	13909671	1961

Sources

Genes for Sigmoid Disease

Genes related to Sigmoid Disease (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HSPBAP1	HSPB1 Associated Protein 1	Protein Coding	5.93	DISEASES inferred ¹⁵
2	FUCA1	Alpha-L-Fucosidase 1	Protein Coding	5.48	DISEASES inferred ¹⁵
3	MAPK8IP2	Mitogen-Activated Protein Kinase 8 Interacting Protein 2	Protein Coding	5.31	DISEASES inferred ¹⁵
4	UBR1	Ubiquitin Protein Ligase E3 Component N-Recognin 1	Protein Coding	5.13	DISEASES inferred ¹⁵
5	KLF5	Kruppel Like Factor 5	Protein Coding	4.56	DISEASES inferred ¹⁵
6	ETV5	ETS Variant Transcription Factor 5	Protein Coding	4.5	DISEASES inferred ¹⁵
7	COX5A	Cytochrome C Oxidase Subunit 5A	Protein Coding	4.45	DISEASES inferred ¹⁵
8	POLI	DNA Polymerase Iota	Protein Coding	4.43	DISEASES inferred ¹⁵
9	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	4.36	DISEASES inferred ¹⁵
10	ADSL	Adenylosuccinate Lyase	Protein Coding	4.28	DISEASES inferred ¹⁵
11	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	3.83	DISEASES inferred ¹⁵
12	TLR10	Toll Like Receptor 10	Protein Coding	3.34	DISEASES inferred ¹⁵
13	TLR6	Toll Like Receptor 6	Protein Coding	3.31	DISEASES inferred ¹⁵
14	TLR8	Toll Like Receptor 8	Protein Coding	3.3	DISEASES inferred ¹⁵
15	TLR1	Toll Like Receptor 1	Protein Coding	3.29	DISEASES inferred ¹⁵
16	TLR5	Toll Like Receptor 5	Protein Coding	3.27	DISEASES inferred ¹⁵

Sources

Variations for Sigmoid Disease

Sources

Expression for Sigmoid Disease

Search GEO for disease gene expression data for Sigmoid Disease.

Sources

Pathways for Sigmoid Disease

Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.19	TLR8 TLR6 TLR5 TLR10 TLR1 MAPK8IP2
2	Toll-like Receptor Signaling Pathway ¹ ³⁶ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ NOD-like Receptor Signaling Pathways ⁶⁴ Regulation of toll-like receptor signaling pathway ¹	12.89	TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
3	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.47	TLR8 TLR6 TLR5 TLR10 TLR1
4	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.33	TLR8 TLR6 TLR5 TLR10 TLR1
5	VEGF Pathway (Qiagen) ⁶⁵ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² VEGF Family Ligands and Receptor Interactions ⁶³ VEGF Pathway ⁶³	12.14	TLR8 TLR6 TLR5 TLR10 TLR1
6	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12	TLR8 TLR6 TLR5 TLR10 TLR1
7	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	11.95	TLR8 TLR6 TLR5 TLR1
8	Tuberculosis ³⁶	11.94	TLR6 TLR1 NOD2
9	Colorectal Cancer Metastasis ⁶³	11.87	TLR8 TLR6 TLR5 TLR10 TLR1
10	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁴	11.67	TLR8 TLR6 TLR5 TLR10 TLR1
11	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.45	TLR8 TLR6 TLR5 TLR10 TLR1
12	Phagocytosis of Microbes ⁶³	10.95	TLR8 TLR6 TLR5 TLR10 TLR1

Sources

GO Terms for Sigmoid Disease

Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	9.8	TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
2	inflammatory response	GO:0006954	9.77	TLR8 TLR6 TLR5 TLR10 TLR1
3	innate immune response	GO:0045087	9.73	TLR8 TLR6 TLR5 TLR10 TLR1 NOD2
4	toll-like receptor signaling pathway	GO:0002224	9.55	TLR8 TLR6 TLR5 TLR10 TLR1
5	microglial cell activation	GO:0001774	9.54	TLR8 TLR6
6	positive regulation of interleukin-8 production	GO:0032757	9.52	TLR5 NOD2
7	positive regulation of endocytosis	GO:0045807	9.51	MAPK8IP2 MAPK8IP1
8	positive regulation of stress-activated MAPK cascade	GO:0032874	9.49	NOD2 MAPK8IP2
9	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.48	TLR6 NOD2
10	regulation of JNK cascade	GO:0046328	9.46	MAPK8IP2 MAPK8IP1
11	positive regulation of interleukin-6 biosynthetic process	GO:0045410	9.43	TLR6 TLR1
12	cell activation	GO:0001775	9.4	TLR6 TLR1
13	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.35	TLR8 TLR6 TLR5 TLR10 TLR1
14	regulation of cytokine secretion	GO:0050707	9.02	TLR8 TLR6 TLR5 TLR10 TLR1

Molecular functions related to Sigmoid Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.17	UBR1 TLR8 TLR6 TLR5 TLR10 TLR1
2	lipopeptide binding	GO:0071723	9.26	TLR6 TLR1
3	MAP-kinase scaffold activity	GO:0005078	9.16	MAPK8IP2 MAPK8IP1
4	transmembrane signaling receptor activity	GO:0004888	9.02	TLR8 TLR6 TLR5 TLR10 TLR1
5	Toll-like receptor 2 binding	GO:0035663	8.96	TLR6 TLR1

Sources

Sources for Sigmoid Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Sigmoid Disease

Aliases & Classifications for Sigmoid Disease

MalaCards integrated aliases for Sigmoid Disease:

Classifications:

External Ids:

Summaries for Sigmoid Disease

Related Diseases for Sigmoid Disease

Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Sigmoid Disease:

Symptoms & Phenotypes for Sigmoid Disease

GenomeRNAi Phenotypes related to Sigmoid Disease according to GeneCards Suite gene sharing:

Drugs & Therapeutics for Sigmoid Disease

Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: sigmoid diseases

Genetic Tests for Sigmoid Disease

Anatomical Context for Sigmoid Disease

MalaCards organs/tissues related to Sigmoid Disease:

Publications for Sigmoid Disease

Articles related to Sigmoid Disease:

Genes for Sigmoid Disease

Genes related to Sigmoid Disease (0 elite genes):

Variations for Sigmoid Disease

Expression for Sigmoid Disease

Pathways for Sigmoid Disease

Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

GO Terms for Sigmoid Disease

Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

Molecular functions related to Sigmoid Disease according to GeneCards Suite gene sharing:

Sources for Sigmoid Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :