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MCID: SGM001
MIFTS: 24

Sigmoid Disease

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Sigmoid Disease

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MalaCards integrated aliases for Sigmoid Disease:

Name: Sigmoid Disease 12 15
Sigmoid Diseases 44 71

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1897
MeSH 44 D012810
UMLS 71 C0037072
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Summaries for Sigmoid Disease

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MalaCards based summary : Sigmoid Disease, also known as sigmoid diseases, is related to lambert-eaton myasthenic syndrome and gastroduodenal crohn's disease. An important gene associated with Sigmoid Disease is ELAVL3 (ELAV Like RNA Binding Protein 3), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Tuberculosis. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon.

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Related Diseases for Sigmoid Disease

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Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 lambert-eaton myasthenic syndrome 10.0 TNF ELAVL3
2 gastroduodenal crohn's disease 9.9 TNF NOD2
3 crohn's disease 9.9 TNF NOD2
4 pouchitis 9.9 TNF NOD2
5 melkersson-rosenthal syndrome 9.9 TNF NOD2
6 gastrointestinal tuberculosis 9.9 TNF NOD2
7 intestinal tuberculosis 9.9 TNF NOD2
8 orofacial granulomatosis 9.9 TNF NOD2
9 chemical colitis 9.9 TNF NOD2
10 colitis 9.9 TNF NOD2
11 enterocolitis 9.9 TNF NOD2
12 tenosynovitis 9.9 TNF NOD2
13 granulomatous dermatitis 9.9 TNF NOD2
14 dermatitis 9.9 TNF NOD2
15 uveoparotid fever 9.9 TNF NOD2
16 ileocolitis 9.9 TNF NOD2
17 anorectal stricture 9.9 TNF NOD2
18 iritis 9.9 TNF NOD2
19 chorioretinitis 9.9 TNF NOD2
20 choroiditis 9.9 TNF NOD2
21 acute graft versus host disease 9.9 TNF NOD2
22 intestinal perforation 9.9 TNF NOD2
23 crohn's colitis 9.9 TNF NOD2
24 mevalonic aciduria 9.9 TNF NOD2
25 perinatal necrotizing enterocolitis 9.9 TNF NOD2
26 panuveitis 9.9 TNF NOD2
27 uveitis 9.9 TNF NOD2
28 hidradenitis 9.9 TNF NOD2
29 hidradenitis suppurativa 9.9 TNF NOD2
30 pyoderma 9.9 TNF NOD2
31 pyoderma gangrenosum 9.9 TNF NOD2
32 erythema nodosum 9.9 TNF NOD2
33 periodic fever, familial, autosomal dominant 9.9 TNF NOD2
34 rectal disease 9.9 TNF NOD2
35 blau syndrome 9.9 TNF NOD2
36 q fever 9.9 TNF NOD2
37 inflammatory bowel disease 1 9.9 TNF NOD2
38 hypersensitivity reaction type iv disease 9.8 TNF NOD2
39 ileitis 9.8 TNF NOD2
40 melioidosis 9.8 TNF NOD2
41 muckle-wells syndrome 9.8 TNF NOD2
42 spondylitis 9.8 TNF NOD2
43 salmonellosis 9.8 TNF NOD2
44 testicular disease 9.8 TNF NOD2
45 uveal disease 9.8 TNF NOD2
46 lymphadenitis 9.8 TNF NOD2
47 osteomyelitis 9.8 TNF NOD2
48 spondyloarthropathy 1 9.8 TNF NOD2
49 aggressive periodontitis 9.8 TNF NOD2
50 familial mediterranean fever 9.8 TNF NOD2

Graphical network of the top 20 diseases related to Sigmoid Disease:



Diseases related to Sigmoid Disease
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Symptoms & Phenotypes for Sigmoid Disease

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Drugs & Therapeutics for Sigmoid Disease

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Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Robotic-assisted Versus Laparoscopic Sigmoid Resection: a Retrospective Chart Review of Benign and Malignant Sigmoid Disease Completed NCT02636673
2 Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak. Completed NCT02662946
3 Randomized Controlled Clinical Trial on Lateral Invagination of the Colorectal Anastomosis by Double Stapling Not yet recruiting NCT04553250

Search NIH Clinical Center for Sigmoid Disease

Inferred drug relations via UMLS 71 / NDF-RT 51 :


mesalamine

Cochrane evidence based reviews: sigmoid diseases

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Genetic Tests for Sigmoid Disease

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Anatomical Context for Sigmoid Disease

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MalaCards organs/tissues related to Sigmoid Disease:

40
Colon
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Publications for Sigmoid Disease

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Articles related to Sigmoid Disease:

(show all 14)
# Title Authors PMID Year
1
Resection margin histology may predict intermediate-term outcomes in children with rectosigmoid Hirschsprung disease. 61
32504125 2020
2
Single-incision versus conventional laparoscopic sigmoid colectomy: a case-matched series. 61
21792717 2012
3
A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood. 61
20725836 2010
4
Long-term quality-of-life after open and laparoscopic sigmoid colectomy. 61
18427335 2008
5
Primary anastomosis after intraoperative colonic lavage vs. Hartmann's procedure in generalized peritonitis complicating diverticular disease of the colon. 61
12910361 2003
6
Intraoperative colonic lavage with primary anastomosis vs. Hartmann's procedure for perforated diverticular disease of the colon: a consecutive study. 61
12063965 2002
7
[An unusual diverticular sigmoid disease]. 61
10617817 1999
8
Smoking may be associated with complications in diverticular disease. 61
10417566 1999
9
Appendicular involvement in perforated sigmoid disease: US and CT findings. 61
10354887 1999
10
Primary anastomosis with transverse colostomy as an alternative to Hartmann's procedure. 61
7749677 1995
11
Level of anastomosis and recurrent colonic diverticulitis. 61
3946763 1986
12
Bladder symptoms due to silent sigmoid disease. 61
5791049 1969
13
[Clinical use of attapulgite by rectal route in the treatment of recto-sigmoid diseases]. 61
4286409 1966
14
[Precancerous ano-recto-sigmoid diseases]. 61
13909671 1961
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Variations for Sigmoid Disease

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Expression for Sigmoid Disease

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Search GEO for disease gene expression data for Sigmoid Disease.
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Pathways for Sigmoid Disease

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Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NOD-like receptor signaling pathway 36
11.51 TNF NOD2
2
Tuberculosis 36
11.41 TNF NOD2
3
TNF signaling pathway 36
11 TNF NOD2
4
Canonical NF-kappaB pathway 1
9.98 TNF NOD2
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GO Terms for Sigmoid Disease

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Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.59 TNF NOD2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.58 TNF NOD2
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.58 TNF NOD2
4 cellular response to lipopolysaccharide GO:0071222 9.57 TNF NOD2
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 TNF NOD2
6 defense response GO:0006952 9.55 TNF NOD2
7 activation of MAPK activity GO:0000187 9.54 TNF NOD2
8 defense response to Gram-positive bacterium GO:0050830 9.52 TNF NOD2
9 regulation of inflammatory response GO:0050727 9.51 TNF NOD2
10 positive regulation of interleukin-6 production GO:0032755 9.49 TNF NOD2
11 positive regulation of JNK cascade GO:0046330 9.48 TNF NOD2
12 cellular response to organic cyclic compound GO:0071407 9.46 TNF NOD2
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.43 TNF NOD2
14 positive regulation of MAP kinase activity GO:0043406 9.4 TNF NOD2
15 positive regulation of interleukin-8 production GO:0032757 9.37 TNF NOD2
16 positive regulation of interleukin-1 beta production GO:0032731 9.32 TNF NOD2
17 JNK cascade GO:0007254 9.26 TNF NOD2
18 positive regulation of phagocytosis GO:0050766 9.16 TNF NOD2
19 positive regulation of cytokine production involved in inflammatory response GO:1900017 8.96 TNF NOD2
20 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 8.62 TNF NOD2
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Sources for Sigmoid Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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