Sigmoid Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sigmoid Disease

MalaCards integrated aliases for Sigmoid Disease:

Name: Sigmoid Disease ¹² ¹⁵

Sigmoid Diseases ⁴³ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1897

MeSH ⁴³ D012810

UMLS ⁷¹ C0037072

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Summaries for Sigmoid Disease

MalaCards based summary : Sigmoid Disease, also known as sigmoid diseases, is related to cervical carcinosarcoma and isthmus cancer. An important gene associated with Sigmoid Disease is ELAVL3 (ELAV Like RNA Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Budesonide and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include colon.

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Related Diseases for Sigmoid Disease

Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	cervical carcinosarcoma	10.3	MAPK8IP2 MAPK8IP1
2	isthmus cancer	10.2	MAPK8IP2 MAPK8IP1
3	cervix small cell carcinoma	10.2	MAPK8IP2 MAPK8IP1
4	papillary squamous carcinoma	10.2	MAPK8IP2 MAPK8IP1
5	lymphocele	10.2	MAPK8IP2 MAPK8IP1
6	cervical adenosquamous carcinoma	10.2	MAPK8IP2 MAPK8IP1
7	vaginal cancer	10.2	MAPK8IP2 MAPK8IP1
8	vaginal discharge	10.1	MAPK8IP2 MAPK8IP1
9	radiation cystitis	10.1	MAPK8IP2 MAPK8IP1 ELAVL3
10	neurosyphilis	10.1	TLR6 TLR1
11	toxic pneumonitis	9.9	TLR8 TLR6 TLR10
12	q fever	9.8	TLR10 TLR1 NOD2
13	endometritis	9.7	TLR6 TLR1
14	diverticulitis	9.7
15	ocular toxoplasmosis	9.7	TLR5 TLR1 NOD2
16	bacteriuria	9.6	TLR5 TLR1
17	juvenile nasopharyngeal angiofibroma	9.6	TLR7 TLR3
18	chlamydia pneumonia	9.6	TLR6 TLR5 TLR1
19	myd88 deficiency	9.6	TLR6 TLR5 TLR1
20	proteasome-associated autoinflammatory syndrome 1	9.5	TLR6 TLR5 TLR3
21	endometrial disease	9.4	TLR6 TLR3 TLR10 TLR1
22	penile disease	9.4	TLR8 TLR7 TLR3
23	lyme disease	9.4	TLR7 TLR6 TLR1
24	anus disease	9.4	TLR8 TLR7 TLR3
25	microphthalmia with limb anomalies	9.4	TLR8 TLR7 TLR3
26	melioidosis	9.4	TLR5 TLR10 TLR1 NOD2
27	dengue hemorrhagic fever	9.4	TLR8 TLR7 TLR3
28	invasive aspergillosis	9.4	TLR6 TLR5 TLR1 NOD2
29	irak4 deficiency	9.3	TLR6 TLR5 TLR10 TLR1
30	potocki-shaffer syndrome	9.3	TLR8 TLR7 TLR3
31	bacterial infectious disease	9.3	TLR5 TLR3 TLR1 NOD2
32	tonsillitis	9.2	TLR5 TLR3 TLR10 TLR1
33	plague	9.2	TLR6 TLR5 TLR3 TLR1
34	crimean-congo hemorrhagic fever	9.2	TLR8 TLR7 TLR3 TLR10
35	viral infectious disease	9.0	TLR8 TLR7 TLR3 TLR1
36	otitis media	8.9	TLR8 TLR7 TLR5 TLR1
37	inflammatory bowel disease	8.7	TLR6 TLR5 TLR3 TLR1 NOD2
38	amyotrophic lateral sclerosis 1	8.7	TLR8 TLR6 TLR5 TLR10 TLR1
39	commensal bacterial infectious disease	8.7	TLR7 TLR5 TLR3 TLR1 ETV5
40	aspergillosis	8.7	TLR6 TLR5 TLR3 TLR10 TLR1 NOD2
41	opportunistic mycosis	8.6	TLR7 TLR6 TLR5 TLR3 TLR1
42	asthma	8.6	TLR6 TLR3 TLR10 TLR1 NOD2
43	integumentary system disease	8.6	TLR8 TLR7 TLR5 TLR3 TLR1
44	bronchiolitis	8.5	TLR8 TLR7 TLR6 TLR3 TLR10 TLR1
45	rectal disease	8.3	TLR8 TLR7 TLR6 TLR5 TLR3 TLR1
46	combat disorder	8.0	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
47	superficial basal cell carcinoma	8.0	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
48	scalp dermatosis	8.0	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
49	coccidiosis	8.0	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
50	vaginal disease	8.0	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

Graphical network of the top 20 diseases related to Sigmoid Disease:

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Symptoms & Phenotypes for Sigmoid Disease

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Drugs & Therapeutics for Sigmoid Disease

Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Budesonide

Approved

Phase 3

51333-22-3

63006 5281004

Synonyms:

(11b,16a)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde

(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde

(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione

16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

51333-22-3

AC1L1DQE

AC1L1Y6Y

AC1L22VC

AC1MHWI7

AC-4697

B 7777

B7777_SIGMA

Bidien

Bio-0010

BPBio1_000523

BRD-A34299591-001-03-4

BRD-A82238138-001-01-7

BSPBio_000475

BSPBio_002160

Budecort Inhaler

Budenofalk

Budeson

Budesónida

budesonide

Budesonide

Budesonide (JAN/USAN/INN)

Budesonide [USAN:INN:BAN:JAN]

Budesonide Easyhaler

Budesonide MMX

Budesonide, (R)-isomer

Budesonide, (S)-isomer

Budesonido

Budesonido [INN-Spanish]

Budesonidum

Budesonidum [INN-Latin]

Budiair

Budicort

C25H34O6

CCRIS 5230

CHEBI:3207

CHEBI:656601

CHEMBL1370

CID2462

CID3033890

CID40000

CID5281004

CID63006

Cortivent

CPD000058337

D00246

DB01222

Desowen

Dexbudesonide

Dexbudesonide [INN]

DivK1c_000475

EINECS 257-139-7

EINECS 257-160-1

EINECS 257-161-7

Entocort

Entocort EC

Entocort EC (TN)

EU-0100174

Giona Easyhaler

HMS1569H17

HMS1921I22

HMS2094I13

HMS501H17

Horacort

IDI1_000475

Inflammide

KBio1_000475

KBio3_001660

KBioGR_001361

Lopac0_000174

LS-187734

LS-7235

MAP-0010

Micronyl

Miflonide

MLS000028507

MLS001077323

MLS002207112

MolPort-002-529-265

MolPort-003-666-332

MolPort-003-986-909

NCGC00015165-03

NCGC00021318-03

NCGC00021318-06

NCGC00089747-02

NCGC00089747-03

NCGC00089747-04

NCGC00178789-01

NINDS_000475

Noex

Preferid

Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Prestwick_840

Prestwick0_000518

Prestwick1_000518

Prestwick2_000518

Prestwick3_000518

Pulmaxan

Pulmaxan turbohaler

Pulmicort

Pulmicort (TN)

Pulmicort Flexhaler

Pulmicort Nebuamp

Pulmicort Respules

Pulmicort Topinasal

Pulmicort turbuhaler

Pulmicort Turbuhaler

Respules

Rhinocort

Rhinocort alpha

Rhinocort Aqua

Rhinocort Turbuhaler

Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide

Rhinosol

S 1320

S1286_Selleck

S-1320

SAM002699898

SMR000058337

SPBio_000586

SPBio_002396

SPECTRUM1500813

Spectrum2_000623

Spectrum3_000620

Spectrum4_000821

Spectrum5_001738

Spirocort

ST51039033

TL8003397

Tridesilon

UDB

UNII-168L5HT37P

UNII-2HI1006KPH

UNII-Q3OKS62Q6X

Unit dose budesonide

ZINC03938751

ZINC04097286

2

Respiratory System Agents

Phase 3

3

Hormone Antagonists

Phase 3

4

Hormones

Phase 3

5

glucocorticoids

Phase 3

6

Cola

Phase 3

7

Anti-Asthmatic Agents

Phase 3

8

Anti-Inflammatory Agents

Phase 3

9

Bronchodilator Agents

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis	Completed	NCT01008423	Phase 3	Budesonide;Placebo
2	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis	Completed	NCT01008410	Phase 3	Budesonide;Placebo
3	A Phase 3, Open Label, Multicenter Study to Assess the Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis	Terminated	NCT01349673	Phase 3	Budesonide Foam
4	Robotic-assisted Versus Laparoscopic Sigmoid Resection: a Retrospective Chart Review of Benign and Malignant Sigmoid Disease	Completed	NCT02636673
5	Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak.	Completed	NCT02662946

Search NIH Clinical Center for Sigmoid Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

mesalamine

Cochrane evidence based reviews: sigmoid diseases

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Genetic Tests for Sigmoid Disease

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Anatomical Context for Sigmoid Disease

MalaCards organs/tissues related to Sigmoid Disease:

⁴⁰

Colon

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Publications for Sigmoid Disease

Articles related to Sigmoid Disease:

(show all 14)

#	Title	Authors	PMID	Year
1	Resection margin histology may predict intermediate-term outcomes in children with rectosigmoid Hirschsprung disease. ⁶¹	Brooks LA...Gosain A	32504125	2020
2	Single-incision versus conventional laparoscopic sigmoid colectomy: a case-matched series. ⁶¹	Ramos-Valadez DI...Haas EM	21792717	2012
3	A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood. ⁶¹	Doodnath R...Puri P	20725836	2010
4	Long-term quality-of-life after open and laparoscopic sigmoid colectomy. ⁶¹	Seitz G...Kreis ME	18427335	2008
5	Primary anastomosis after intraoperative colonic lavage vs. Hartmann's procedure in generalized peritonitis complicating diverticular disease of the colon. ⁶¹	Regenet N...Arnaud JP	12910361	2003
6	Intraoperative colonic lavage with primary anastomosis vs. Hartmann's procedure for perforated diverticular disease of the colon: a consecutive study. ⁶¹	Regenet N...Arnaud JP	12063965	2002
7	[An unusual diverticular sigmoid disease]. ⁶¹	Lorin De La Grandmaison G...Janin A	10617817	1999
8	Smoking may be associated with complications in diverticular disease. ⁶¹	Papagrigoriadis S...Rennie JA	10417566	1999
9	Appendicular involvement in perforated sigmoid disease: US and CT findings. ⁶¹	Ripolles T...Morote V	10354887	1999
10	Primary anastomosis with transverse colostomy as an alternative to Hartmann's procedure. ⁶¹	Maddern GJ...Launois B	7749677	1995
11	Level of anastomosis and recurrent colonic diverticulitis. ⁶¹	Benn PL...Ilstrup DM	3946763	1986
12	Bladder symptoms due to silent sigmoid disease. ⁶¹	Gibson TE	5791049	1969
13	[Clinical use of attapulgite by rectal route in the treatment of recto-sigmoid diseases]. ⁶¹	Heully F...Penin F	4286409	1966
14	[Precancerous ano-recto-sigmoid diseases]. ⁶¹	SCHWARTZ A...MATELUNA E	13909671	1961

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Genes for Sigmoid Disease

Genes related to Sigmoid Disease (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ELAVL3	ELAV Like RNA Binding Protein 3	Protein Coding	5.79	DISEASES inferred ¹⁵
2	MAPK8IP2	Mitogen-Activated Protein Kinase 8 Interacting Protein 2	Protein Coding	5.37	DISEASES inferred ¹⁵
3	ETV5	ETS Variant Transcription Factor 5	Protein Coding	4.55	DISEASES inferred ¹⁵
4	COX5A	Cytochrome C Oxidase Subunit 5A	Protein Coding	4.51	DISEASES inferred ¹⁵
5	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	4.44	DISEASES inferred ¹⁵
6	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	3.89	DISEASES inferred ¹⁵
7	TLR10	Toll Like Receptor 10	Protein Coding	3.39	DISEASES inferred ¹⁵
8	TLR6	Toll Like Receptor 6	Protein Coding	3.37	DISEASES inferred ¹⁵
9	TLR8	Toll Like Receptor 8	Protein Coding	3.35	DISEASES inferred ¹⁵
10	TLR1	Toll Like Receptor 1	Protein Coding	3.34	DISEASES inferred ¹⁵
11	TLR5	Toll Like Receptor 5	Protein Coding	3.33	DISEASES inferred ¹⁵
12	TLR7	Toll Like Receptor 7	Protein Coding	3.25	DISEASES inferred ¹⁵
13	TLR3	Toll Like Receptor 3	Protein Coding	3.24	DISEASES inferred ¹⁵

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Variations for Sigmoid Disease

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Expression for Sigmoid Disease

Search GEO for disease gene expression data for Sigmoid Disease.

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Pathways for Sigmoid Disease

Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.77	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
2	Activated TLR4 signalling ⁶⁵ Show member pathways activated TAK1 mediates p38 MAPK activation ⁶⁵ Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon ⁶⁵ IRAK2 mediated activation of TAK1 complex ⁶⁵ IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation ⁶⁵ JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 ⁶⁵ MAP kinase activation in TLR cascade ⁶⁵ MyD88 cascade initiated on plasma membrane ⁶⁵ MyD88 dependent cascade initiated on endosome ⁶⁵ MyD88-independent TLR3/TLR4 cascade ⁶⁵ MyD88-Mal cascade initiated on plasma membrane ⁶⁵ Regulation of TLR by endogenous ligand ⁶⁵ TICAM1 deficiency - HSE ⁶⁵ Toll Like Receptor 10 (TLR10) Cascade ⁶⁵ Toll Like Receptor 2 (TLR2) Cascade ⁶⁵ Toll Like Receptor 3 (TLR3) Cascade ⁶⁵ Toll Like Receptor 4 (TLR4) Cascade ⁶⁵ Toll Like Receptor 5 (TLR5) Cascade ⁶⁵ Toll Like Receptor 7/8 (TLR7/8) Cascade ⁶⁵ Toll Like Receptor 9 (TLR9) Cascade ⁶⁵ Toll Like Receptor TLR1-TLR2 Cascade ⁶⁵ Toll Like Receptor TLR6-TLR2 Cascade ⁶⁵ Toll-Like Receptors Cascades ⁶⁵ TRAF3 deficiency - HSE ⁶⁵ TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation ⁶⁵ TRAF6 mediated induction of TAK1 complex ⁶⁵ TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling ⁶⁵ Trafficking and processing of endosomal TLR ⁶⁵ Transfer of LPS from LBP carrier to CD14 ⁶⁵ TRIF-mediated programmed cell death ⁶⁵ TRIF-mediated TLR3/TLR4 signaling ⁶⁵	13.43	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.3	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
4	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.06	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
5	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.92	TLR8 TLR7 TLR6 TLR5 TLR3 TLR1
6	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.64	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
7	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.64	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
8	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.53	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
9	NF-kappaB Signaling ⁴	12.45	TLR8 TLR7 TLR6 TLR3 TLR1
10	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.35	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
11	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.19	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
12	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.13	TLR8 TLR7 TLR6 TLR5 TLR1
13	Colorectal Cancer Metastasis ⁶³	12.08	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
14	Tuberculosis ³⁶	12	TLR6 TLR1 NOD2
15	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.89	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
16	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	11.73	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
17	Th17 Differentiation ⁶⁴ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.46	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
18	Phagocytosis of Microbes ⁶³	11.1	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

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GO Terms for Sigmoid Disease

Cellular components related to Sigmoid Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.65	TLR8 TLR7 TLR6 TLR5 TLR10 TLR1
2	endolysosome membrane	GO:0036020	8.8	TLR8 TLR7 TLR3

Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 40)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.14	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
2	immune system process	GO:0002376	9.97	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
3	immune response	GO:0006955	9.96	TLR8 TLR7 TLR6 TLR10 TLR1
4	defense response to bacterium	GO:0042742	9.88	TLR6 TLR5 TLR3 NOD2
5	inflammatory response	GO:0006954	9.87	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
6	innate immune response	GO:0045087	9.86	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
7	defense response to virus	GO:0051607	9.85	TLR8 TLR7 TLR3
8	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.85	TLR6 TLR3 NOD2
9	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.84	TLR6 TLR3 NOD2
10	defense response	GO:0006952	9.83	TLR3 TLR1 NOD2
11	cellular response to mechanical stimulus	GO:0071260	9.83	TLR8 TLR7 TLR5 TLR3
12	positive regulation of interleukin-6 production	GO:0032755	9.8	TLR8 TLR7 TLR3 NOD2
13	positive regulation of inflammatory response	GO:0050729	9.78	TLR7 TLR3 TLR10
14	positive regulation of JNK cascade	GO:0046330	9.77	TLR3 NOD2 MAPK8IP1
15	microglial cell activation	GO:0001774	9.76	TLR8 TLR7 TLR6 TLR3
16	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.75	TLR8 TLR7 TLR3
17	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.74	TLR7 TLR3 NOD2
18	positive regulation of interleukin-8 production	GO:0032757	9.73	TLR7 TLR5 TLR3 NOD2
19	positive regulation of interferon-gamma biosynthetic process	GO:0045078	9.69	TLR8 TLR7 TLR3
20	positive regulation of interleukin-1 beta secretion	GO:0050718	9.68	TLR8 NOD2
21	positive regulation of cytokine production	GO:0001819	9.68	TLR5 TLR3
22	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	9.67	TLR6 TLR3
23	positive regulation of endocytosis	GO:0045807	9.66	MAPK8IP2 MAPK8IP1
24	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.65	TLR6 NOD2
25	positive regulation of stress-activated MAPK cascade	GO:0032874	9.65	NOD2 MAPK8IP2
26	regulation of JNK cascade	GO:0046328	9.65	MAPK8IP2 MAPK8IP1
27	positive regulation of interferon-beta biosynthetic process	GO:0045359	9.65	TLR8 TLR7 TLR3
28	positive regulation of chemokine production	GO:0032722	9.64	TLR7 TLR3
29	activation of NF-kappaB-inducing kinase activity	GO:0007250	9.64	TLR6 TLR3
30	toll-like receptor 9 signaling pathway	GO:0034162	9.63	TLR8 TLR7
31	positive regulation of interleukin-6 biosynthetic process	GO:0045410	9.63	TLR6 TLR1
32	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.62	TLR8 TLR7
33	cell activation	GO:0001775	9.62	TLR6 TLR1
34	I-kappaB phosphorylation	GO:0007252	9.61	TLR7 TLR3
35	cellular response to bacterial lipopeptide	GO:0071221	9.59	TLR6 TLR1
36	positive regulation of interferon-alpha biosynthetic process	GO:0045356	9.58	TLR8 TLR7 TLR3
37	positive regulation of toll-like receptor signaling pathway	GO:0034123	9.55	TLR5 TLR3
38	regulation of cytokine secretion	GO:0050707	9.55	TLR8 TLR6 TLR5 TLR10 TLR1
39	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.43	TLR8 TLR7 TLR6 TLR5 TLR10 TLR1
40	toll-like receptor signaling pathway	GO:0002224	9.17	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

Molecular functions related to Sigmoid Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	double-stranded RNA binding	GO:0003725	9.58	TLR8 TLR7 TLR3
2	NAD+ nucleotidase, cyclic ADP-ribose generating	GO:0061809	9.5	TLR6 TLR10 TLR1
3	MAP-kinase scaffold activity	GO:0005078	9.46	MAPK8IP2 MAPK8IP1
4	lipopeptide binding	GO:0071723	9.43	TLR6 TLR1
5	NAD(P)+ nucleosidase activity	GO:0050135	9.43	TLR6 TLR10 TLR1
6	signaling receptor activity	GO:0038023	9.43	TLR8 TLR6 TLR5 TLR3 TLR10 TLR1
7	Toll-like receptor 2 binding	GO:0035663	9.37	TLR6 TLR1
8	pattern recognition receptor activity	GO:0038187	9.33	TLR8 TLR7 NOD2
9	transmembrane signaling receptor activity	GO:0004888	9.17	TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

Sources

Sources for Sigmoid Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Sigmoid Disease

Aliases & Classifications for Sigmoid Disease

MalaCards integrated aliases for Sigmoid Disease:

Classifications:

External Ids:

Summaries for Sigmoid Disease

Related Diseases for Sigmoid Disease

Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Sigmoid Disease:

Symptoms & Phenotypes for Sigmoid Disease

Drugs & Therapeutics for Sigmoid Disease

Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: sigmoid diseases

Genetic Tests for Sigmoid Disease

Anatomical Context for Sigmoid Disease

MalaCards organs/tissues related to Sigmoid Disease:

Publications for Sigmoid Disease

Articles related to Sigmoid Disease:

Genes for Sigmoid Disease

Genes related to Sigmoid Disease (0 elite genes):

Variations for Sigmoid Disease

Expression for Sigmoid Disease

Pathways for Sigmoid Disease

Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

GO Terms for Sigmoid Disease

Cellular components related to Sigmoid Disease according to GeneCards Suite gene sharing:

Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

Molecular functions related to Sigmoid Disease according to GeneCards Suite gene sharing:

Sources for Sigmoid Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :