MCID: SGM001
MIFTS: 30

Sigmoid Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Sigmoid Disease

MalaCards integrated aliases for Sigmoid Disease:

Name: Sigmoid Disease 12 15
Sigmoid Diseases 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1897
MeSH 43 D012810
UMLS 71 C0037072

Summaries for Sigmoid Disease

MalaCards based summary : Sigmoid Disease, also known as sigmoid diseases, is related to cervical carcinosarcoma and isthmus cancer. An important gene associated with Sigmoid Disease is ELAVL3 (ELAV Like RNA Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Budesonide and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include colon.

Related Diseases for Sigmoid Disease

Diseases related to Sigmoid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 cervical carcinosarcoma 10.3 MAPK8IP2 MAPK8IP1
2 isthmus cancer 10.2 MAPK8IP2 MAPK8IP1
3 cervix small cell carcinoma 10.2 MAPK8IP2 MAPK8IP1
4 papillary squamous carcinoma 10.2 MAPK8IP2 MAPK8IP1
5 lymphocele 10.2 MAPK8IP2 MAPK8IP1
6 cervical adenosquamous carcinoma 10.2 MAPK8IP2 MAPK8IP1
7 vaginal cancer 10.2 MAPK8IP2 MAPK8IP1
8 vaginal discharge 10.1 MAPK8IP2 MAPK8IP1
9 radiation cystitis 10.1 MAPK8IP2 MAPK8IP1 ELAVL3
10 neurosyphilis 10.1 TLR6 TLR1
11 toxic pneumonitis 9.9 TLR8 TLR6 TLR10
12 q fever 9.8 TLR10 TLR1 NOD2
13 endometritis 9.7 TLR6 TLR1
14 diverticulitis 9.7
15 ocular toxoplasmosis 9.7 TLR5 TLR1 NOD2
16 bacteriuria 9.6 TLR5 TLR1
17 juvenile nasopharyngeal angiofibroma 9.6 TLR7 TLR3
18 chlamydia pneumonia 9.6 TLR6 TLR5 TLR1
19 myd88 deficiency 9.6 TLR6 TLR5 TLR1
20 proteasome-associated autoinflammatory syndrome 1 9.5 TLR6 TLR5 TLR3
21 endometrial disease 9.4 TLR6 TLR3 TLR10 TLR1
22 penile disease 9.4 TLR8 TLR7 TLR3
23 lyme disease 9.4 TLR7 TLR6 TLR1
24 anus disease 9.4 TLR8 TLR7 TLR3
25 microphthalmia with limb anomalies 9.4 TLR8 TLR7 TLR3
26 melioidosis 9.4 TLR5 TLR10 TLR1 NOD2
27 dengue hemorrhagic fever 9.4 TLR8 TLR7 TLR3
28 invasive aspergillosis 9.4 TLR6 TLR5 TLR1 NOD2
29 irak4 deficiency 9.3 TLR6 TLR5 TLR10 TLR1
30 potocki-shaffer syndrome 9.3 TLR8 TLR7 TLR3
31 bacterial infectious disease 9.3 TLR5 TLR3 TLR1 NOD2
32 tonsillitis 9.2 TLR5 TLR3 TLR10 TLR1
33 plague 9.2 TLR6 TLR5 TLR3 TLR1
34 crimean-congo hemorrhagic fever 9.2 TLR8 TLR7 TLR3 TLR10
35 viral infectious disease 9.0 TLR8 TLR7 TLR3 TLR1
36 otitis media 8.9 TLR8 TLR7 TLR5 TLR1
37 inflammatory bowel disease 8.7 TLR6 TLR5 TLR3 TLR1 NOD2
38 amyotrophic lateral sclerosis 1 8.7 TLR8 TLR6 TLR5 TLR10 TLR1
39 commensal bacterial infectious disease 8.7 TLR7 TLR5 TLR3 TLR1 ETV5
40 aspergillosis 8.7 TLR6 TLR5 TLR3 TLR10 TLR1 NOD2
41 opportunistic mycosis 8.6 TLR7 TLR6 TLR5 TLR3 TLR1
42 asthma 8.6 TLR6 TLR3 TLR10 TLR1 NOD2
43 integumentary system disease 8.6 TLR8 TLR7 TLR5 TLR3 TLR1
44 bronchiolitis 8.5 TLR8 TLR7 TLR6 TLR3 TLR10 TLR1
45 rectal disease 8.3 TLR8 TLR7 TLR6 TLR5 TLR3 TLR1
46 combat disorder 8.0 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
47 superficial basal cell carcinoma 8.0 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
48 scalp dermatosis 8.0 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
49 coccidiosis 8.0 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
50 vaginal disease 8.0 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

Graphical network of the top 20 diseases related to Sigmoid Disease:



Diseases related to Sigmoid Disease

Symptoms & Phenotypes for Sigmoid Disease

Drugs & Therapeutics for Sigmoid Disease

Drugs for Sigmoid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3 51333-22-3 63006 5281004
2 Respiratory System Agents Phase 3
3 Hormone Antagonists Phase 3
4 Hormones Phase 3
5 glucocorticoids Phase 3
6 Cola Phase 3
7 Anti-Asthmatic Agents Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Bronchodilator Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
2 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Budesonide Foam (2 mg/25 mL BID for 2 Weeks, Followed by 2 mg/25 mL QD for 4 Weeks) Versus Placebo in Subjects With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
3 A Phase 3, Open Label, Multicenter Study to Assess the Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Terminated NCT01349673 Phase 3 Budesonide Foam
4 Robotic-assisted Versus Laparoscopic Sigmoid Resection: a Retrospective Chart Review of Benign and Malignant Sigmoid Disease Completed NCT02636673
5 Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak. Completed NCT02662946

Search NIH Clinical Center for Sigmoid Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


mesalamine

Cochrane evidence based reviews: sigmoid diseases

Genetic Tests for Sigmoid Disease

Anatomical Context for Sigmoid Disease

MalaCards organs/tissues related to Sigmoid Disease:

40
Colon

Publications for Sigmoid Disease

Articles related to Sigmoid Disease:

(show all 14)
# Title Authors PMID Year
1
Resection margin histology may predict intermediate-term outcomes in children with rectosigmoid Hirschsprung disease. 61
32504125 2020
2
Single-incision versus conventional laparoscopic sigmoid colectomy: a case-matched series. 61
21792717 2012
3
A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood. 61
20725836 2010
4
Long-term quality-of-life after open and laparoscopic sigmoid colectomy. 61
18427335 2008
5
Primary anastomosis after intraoperative colonic lavage vs. Hartmann's procedure in generalized peritonitis complicating diverticular disease of the colon. 61
12910361 2003
6
Intraoperative colonic lavage with primary anastomosis vs. Hartmann's procedure for perforated diverticular disease of the colon: a consecutive study. 61
12063965 2002
7
[An unusual diverticular sigmoid disease]. 61
10617817 1999
8
Smoking may be associated with complications in diverticular disease. 61
10417566 1999
9
Appendicular involvement in perforated sigmoid disease: US and CT findings. 61
10354887 1999
10
Primary anastomosis with transverse colostomy as an alternative to Hartmann's procedure. 61
7749677 1995
11
Level of anastomosis and recurrent colonic diverticulitis. 61
3946763 1986
12
Bladder symptoms due to silent sigmoid disease. 61
5791049 1969
13
[Clinical use of attapulgite by rectal route in the treatment of recto-sigmoid diseases]. 61
4286409 1966
14
[Precancerous ano-recto-sigmoid diseases]. 61
13909671 1961

Variations for Sigmoid Disease

Expression for Sigmoid Disease

Search GEO for disease gene expression data for Sigmoid Disease.

Pathways for Sigmoid Disease

Pathways related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
2
Show member pathways
13.43 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
3
Show member pathways
13.3 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
4
Show member pathways
13.06 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
5
Show member pathways
12.92 TLR8 TLR7 TLR6 TLR5 TLR3 TLR1
6
Show member pathways
12.64 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
7
Show member pathways
12.64 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
8
Show member pathways
12.53 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
9 12.45 TLR8 TLR7 TLR6 TLR3 TLR1
10
Show member pathways
12.35 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
11
Show member pathways
12.19 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
12
Show member pathways
12.13 TLR8 TLR7 TLR6 TLR5 TLR1
13 12.08 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
14 12 TLR6 TLR1 NOD2
15
Show member pathways
11.89 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
16
Show member pathways
11.73 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
17
Show member pathways
11.46 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
18 11.1 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

GO Terms for Sigmoid Disease

Cellular components related to Sigmoid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.65 TLR8 TLR7 TLR6 TLR5 TLR10 TLR1
2 endolysosome membrane GO:0036020 8.8 TLR8 TLR7 TLR3

Biological processes related to Sigmoid Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.14 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
2 immune system process GO:0002376 9.97 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
3 immune response GO:0006955 9.96 TLR8 TLR7 TLR6 TLR10 TLR1
4 defense response to bacterium GO:0042742 9.88 TLR6 TLR5 TLR3 NOD2
5 inflammatory response GO:0006954 9.87 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
6 innate immune response GO:0045087 9.86 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10
7 defense response to virus GO:0051607 9.85 TLR8 TLR7 TLR3
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 TLR6 TLR3 NOD2
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 TLR6 TLR3 NOD2
10 defense response GO:0006952 9.83 TLR3 TLR1 NOD2
11 cellular response to mechanical stimulus GO:0071260 9.83 TLR8 TLR7 TLR5 TLR3
12 positive regulation of interleukin-6 production GO:0032755 9.8 TLR8 TLR7 TLR3 NOD2
13 positive regulation of inflammatory response GO:0050729 9.78 TLR7 TLR3 TLR10
14 positive regulation of JNK cascade GO:0046330 9.77 TLR3 NOD2 MAPK8IP1
15 microglial cell activation GO:0001774 9.76 TLR8 TLR7 TLR6 TLR3
16 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.75 TLR8 TLR7 TLR3
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.74 TLR7 TLR3 NOD2
18 positive regulation of interleukin-8 production GO:0032757 9.73 TLR7 TLR5 TLR3 NOD2
19 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.69 TLR8 TLR7 TLR3
20 positive regulation of interleukin-1 beta secretion GO:0050718 9.68 TLR8 NOD2
21 positive regulation of cytokine production GO:0001819 9.68 TLR5 TLR3
22 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.67 TLR6 TLR3
23 positive regulation of endocytosis GO:0045807 9.66 MAPK8IP2 MAPK8IP1
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 TLR6 NOD2
25 positive regulation of stress-activated MAPK cascade GO:0032874 9.65 NOD2 MAPK8IP2
26 regulation of JNK cascade GO:0046328 9.65 MAPK8IP2 MAPK8IP1
27 positive regulation of interferon-beta biosynthetic process GO:0045359 9.65 TLR8 TLR7 TLR3
28 positive regulation of chemokine production GO:0032722 9.64 TLR7 TLR3
29 activation of NF-kappaB-inducing kinase activity GO:0007250 9.64 TLR6 TLR3
30 toll-like receptor 9 signaling pathway GO:0034162 9.63 TLR8 TLR7
31 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.63 TLR6 TLR1
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.62 TLR8 TLR7
33 cell activation GO:0001775 9.62 TLR6 TLR1
34 I-kappaB phosphorylation GO:0007252 9.61 TLR7 TLR3
35 cellular response to bacterial lipopeptide GO:0071221 9.59 TLR6 TLR1
36 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.58 TLR8 TLR7 TLR3
37 positive regulation of toll-like receptor signaling pathway GO:0034123 9.55 TLR5 TLR3
38 regulation of cytokine secretion GO:0050707 9.55 TLR8 TLR6 TLR5 TLR10 TLR1
39 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.43 TLR8 TLR7 TLR6 TLR5 TLR10 TLR1
40 toll-like receptor signaling pathway GO:0002224 9.17 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

Molecular functions related to Sigmoid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.58 TLR8 TLR7 TLR3
2 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.5 TLR6 TLR10 TLR1
3 MAP-kinase scaffold activity GO:0005078 9.46 MAPK8IP2 MAPK8IP1
4 lipopeptide binding GO:0071723 9.43 TLR6 TLR1
5 NAD(P)+ nucleosidase activity GO:0050135 9.43 TLR6 TLR10 TLR1
6 signaling receptor activity GO:0038023 9.43 TLR8 TLR6 TLR5 TLR3 TLR10 TLR1
7 Toll-like receptor 2 binding GO:0035663 9.37 TLR6 TLR1
8 pattern recognition receptor activity GO:0038187 9.33 TLR8 TLR7 NOD2
9 transmembrane signaling receptor activity GO:0004888 9.17 TLR8 TLR7 TLR6 TLR5 TLR3 TLR10

Sources for Sigmoid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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