MCID: SGM002
MIFTS: 33

Sigmoid Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Sigmoid Neoplasm

MalaCards integrated aliases for Sigmoid Neoplasm:

Name: Sigmoid Neoplasm 12 15
Sigmoid Neoplasms 44 73
Neoplasm of Sigmoid Colon 12
Tumor of Sigmoid Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1896
MeSH 44 D012811
ICD10 33 C18.7
UMLS 73 C0037073

Summaries for Sigmoid Neoplasm

MalaCards based summary : Sigmoid Neoplasm, also known as sigmoid neoplasms, is related to urachal adenocarcinoma and pancreatic cystadenocarcinoma. An important gene associated with Sigmoid Neoplasm is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Signaling by FGFR2. The drugs Cola and Udenafil have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Sigmoid Neoplasm

Diseases related to Sigmoid Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 urachal adenocarcinoma 10.0 CEACAM5 KRAS
2 pancreatic cystadenocarcinoma 10.0 CEACAM5 KRAS
3 colonic benign neoplasm 10.0 CEACAM5 KRAS
4 ovarian cancer 1 10.0 CEACAM5 KRAS
5 gallbladder disease 10.0 CEACAM5 KRAS
6 cystadenocarcinoma 10.0 CEACAM5 HRAS
7 thyroid carcinoma, familial medullary 10.0 CEACAM5 KRAS
8 fetal adenoma 10.0 CEACAM5 HRAS
9 prostate squamous cell carcinoma 10.0 CEACAM5 HRAS
10 pancreatic mucinous cystadenoma 9.9 CEACAM5 HRAS
11 mixed cell type cancer 9.9 CEACAM5 HRAS
12 gallbladder cancer 9.9 CEACAM5 KRAS
13 periampullary adenoma 9.9 HRAS KRAS
14 paronychia 9.9 HRAS KRAS
15 schimmelpenning-feuerstein-mims syndrome 9.9 HRAS KRAS
16 bile duct cysts 9.9 HRAS KRAS
17 appendix disease 9.9 HRAS KRAS
18 lung adenoid cystic carcinoma 9.9 HRAS KRAS
19 nasal cavity adenocarcinoma 9.9 HRAS KRAS
20 colon adenocarcinoma 9.9 CEACAM5 KRAS
21 secondary hypertrophic osteoarthropathy 9.9 HRAS KRAS
22 anal canal adenocarcinoma 9.9 HRAS KRAS
23 ovarian cystadenocarcinoma 9.9 HRAS KRAS
24 acneiform dermatitis 9.9 HRAS KRAS
25 colloid carcinoma of the pancreas 9.9 HRAS KRAS
26 core binding factor acute myeloid leukemia 9.9 HRAS KRAS
27 biliary tract neoplasm 9.9 HRAS KRAS
28 mucinous lung adenocarcinoma 9.9 HRAS KRAS
29 duodenum cancer 9.9 HRAS KRAS
30 liver angiosarcoma 9.9 HRAS KRAS
31 cecum adenocarcinoma 9.9 HRAS KRAS
32 adenosquamous lung carcinoma 9.9 HRAS KRAS
33 costello syndrome 9.9 HRAS KRAS
34 ampulla of vater cancer 9.9 HRAS KRAS
35 exanthem 9.9 HRAS KRAS
36 pulmonic stenosis 9.9 HRAS KRAS
37 lung benign neoplasm 9.9 HRAS KRAS
38 small intestine cancer 9.9 HRAS KRAS
39 cardiofaciocutaneous syndrome 1 9.9 HRAS KRAS
40 nevus, epidermal 9.9 HRAS KRAS
41 pancreas disease 9.9 HRAS KRAS
42 gastrointestinal stromal tumor 9.9
43 perivascular epithelioid cell tumor 9.9
44 colorectal adenoma 9.9 HRAS KRAS
45 carcinosarcoma 9.9 HRAS KRAS
46 leukemia, chronic lymphocytic 2 9.9 HRAS KRAS
47 adamantinoma of long bones 9.9 CEACAM5 KRAS
48 thyroid cancer, nonmedullary, 2 9.9 CEACAM5 HRAS
49 noonan syndrome 3 9.9 HRAS KRAS
50 differentiated thyroid carcinoma 9.8 HRAS KRAS

Graphical network of the top 20 diseases related to Sigmoid Neoplasm:



Diseases related to Sigmoid Neoplasm

Symptoms & Phenotypes for Sigmoid Neoplasm

GenomeRNAi Phenotypes related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.73 HRAS KRAS
2 Decreased viability GR00106-A-0 9.73 KRAS
3 Decreased viability GR00221-A-1 9.73 HRAS KRAS
4 Decreased viability GR00221-A-2 9.73 HRAS KRAS
5 Decreased viability GR00221-A-3 9.73 HRAS
6 Decreased viability GR00301-A 9.73 KRAS
7 Decreased viability GR00381-A-1 9.73 KRAS
8 Decreased viability GR00402-S-2 9.73 HRAS KRAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.47 KRAS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.47 KRAS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.47 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.47 HRAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.47 HRAS KRAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.47 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.47 HRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.47 KRAS
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.47 KRAS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 KRAS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.47 HRAS
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.47 KRAS

Drugs & Therapeutics for Sigmoid Neoplasm

Drugs for Sigmoid Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 4,Phase 2,Not Applicable
2
Udenafil Investigational Phase 2 268203-93-6 6918523
3 Phosphodiesterase Inhibitors Phase 2
4 Phosphodiesterase 5 Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL) Not yet recruiting NCT03083951 Phase 4
2 Efficacy of Udenafil After Radical Resection for Sigmoid Colon and Rectal Cancer Completed NCT00607282 Phase 2 Udenafil
3 The Effects of Mechnikov Probiotics on Symptom and Surgical Outcome Completed NCT03531606 Not Applicable Mechnicov probiotics;Placebo
4 A Study of Perfusion of Colorectal Anastomosis Using FLuorescence AnGiography (FLAG-trial) Recruiting NCT03390517 Not Applicable
5 Sigmoid Colon Organ Motion in Radiotherapy Recruiting NCT03259828 Not Applicable
6 Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers Recruiting NCT02222844 Not Applicable
7 Five Year Oncological Outcome After CME for Sigmoid Colon Cancer Active, not recruiting NCT03774134
8 Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery Not yet recruiting NCT03628248 Not Applicable
9 Length of Hospital Stay, Nursing Hours and Recovery After Laparoscopic Versus Open Colon Resection Without Fast Track Terminated NCT01127425 Not Applicable

Search NIH Clinical Center for Sigmoid Neoplasm

Cochrane evidence based reviews: sigmoid neoplasms

Genetic Tests for Sigmoid Neoplasm

Anatomical Context for Sigmoid Neoplasm

MalaCards organs/tissues related to Sigmoid Neoplasm:

41
Colon, Lung, Liver, Ovary, Pancreas, Thyroid, Small Intestine

Publications for Sigmoid Neoplasm

Articles related to Sigmoid Neoplasm:

# Title Authors Year
1
Non-absorbable suture granuloma mimicking a retroperitoneal metastatic implant in a patient with sigmoid neoplasm. ( 27615018 )
2016

Variations for Sigmoid Neoplasm

Expression for Sigmoid Neoplasm

Search GEO for disease gene expression data for Sigmoid Neoplasm.

Pathways for Sigmoid Neoplasm

Pathways related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 CEACAM5 HRAS KRAS
2
Show member pathways
12.01 HRAS KRAS
3
Show member pathways
11.97 HRAS KRAS
4 11.96 HRAS KRAS
5
Show member pathways
11.96 HRAS KRAS
6
Show member pathways
11.94 HRAS KRAS
7
Show member pathways
11.93 HRAS KRAS
8 11.93 HRAS KRAS
9 11.91 HRAS KRAS
10
Show member pathways
11.91 HRAS KRAS
11
Show member pathways
11.91 HRAS KRAS
12 11.88 HRAS KRAS
13
Show member pathways
11.88 HRAS KRAS
14
Show member pathways
11.88 HRAS KRAS
15
Show member pathways
11.88 HRAS KRAS
16 11.83 HRAS KRAS
17
Show member pathways
11.83 HRAS KRAS
18 11.82 HRAS KRAS
19
Show member pathways
11.82 HRAS KRAS
20
Show member pathways
11.81 HRAS KRAS
21
Show member pathways
11.79 HRAS KRAS
22 11.79 HRAS KRAS
23
Show member pathways
11.79 HRAS KRAS
24
Show member pathways
11.78 HRAS KRAS
25 11.77 HRAS KRAS
26
Show member pathways
11.75 HRAS KRAS
27 11.74 HRAS KRAS
28 11.72 HRAS KRAS
29 11.71 HRAS KRAS
30 11.7 HRAS KRAS
31 11.7 HRAS KRAS
32 11.69 HRAS KRAS
33 11.67 HRAS KRAS
34
Show member pathways
11.66 HRAS KRAS
35 11.61 HRAS KRAS
36 11.61 HRAS KRAS
37
Show member pathways
11.57 HRAS KRAS
38
Show member pathways
11.55 HRAS KRAS
39 11.54 HRAS KRAS
40
Show member pathways
11.5 HRAS KRAS
41 11.44 HRAS KRAS
42 11.38 HRAS KRAS
43 11.37 HRAS KRAS
44
Show member pathways
11.36 HRAS KRAS
45 11.33 HRAS KRAS
46 11.31 HRAS KRAS
47 11.28 HRAS KRAS
48 11.19 HRAS KRAS
49 11.12 HRAS KRAS
50
Show member pathways
11.05 CEACAM5 HRAS KRAS

GO Terms for Sigmoid Neoplasm

Biological processes related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.4 HRAS KRAS
2 negative regulation of neuron apoptotic process GO:0043524 9.37 HRAS KRAS
3 Ras protein signal transduction GO:0007265 9.32 HRAS KRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 HRAS KRAS
5 positive regulation of MAP kinase activity GO:0043406 9.16 HRAS KRAS
6 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 HRAS KRAS
7 response to isolation stress GO:0035900 8.62 HRAS KRAS

Molecular functions related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 HRAS KRAS

Sources for Sigmoid Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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