MCID: SGM002
MIFTS: 33

Sigmoid Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Sigmoid Neoplasm

MalaCards integrated aliases for Sigmoid Neoplasm:

Name: Sigmoid Neoplasm 12 15
Sigmoid Neoplasms 44 73
Neoplasm of Sigmoid Colon 12
Tumor of Sigmoid Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1896
MeSH 44 D012811
SNOMED-CT 68 126845000 254581007
ICD10 33 C18.7
UMLS 73 C0037073

Summaries for Sigmoid Neoplasm

MalaCards based summary : Sigmoid Neoplasm, also known as sigmoid neoplasms, is related to colonic benign neoplasm and pancreatic cystadenocarcinoma. An important gene associated with Sigmoid Neoplasm is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and VEGF Signaling Pathway. The drugs Cola and Udenafil have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Sigmoid Neoplasm

Diseases related to Sigmoid Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 colonic benign neoplasm 10.1 CEACAM5 KRAS
2 pancreatic cystadenocarcinoma 10.1 CEACAM5 KRAS
3 colon adenocarcinoma 9.9 CEACAM5 KRAS
4 thyroid carcinoma, familial medullary 9.9 CEACAM5 KRAS
5 prostate squamous cell carcinoma 9.8 CEACAM5 HRAS
6 gallbladder cancer 9.8 CEACAM5 KRAS
7 pancreatic mucinous cystadenoma 9.8 CEACAM5 HRAS
8 schimmelpenning-feuerstein-mims syndrome 9.8 HRAS KRAS
9 periampullary adenoma 9.8 HRAS KRAS
10 paronychia 9.8 HRAS KRAS
11 bile duct cysts 9.8 HRAS KRAS
12 perivascular epithelioid cell tumor 9.8
13 pancreatitis 9.8
14 secondary hypertrophic osteoarthropathy 9.8 HRAS KRAS
15 nasal cavity adenocarcinoma 9.8 HRAS KRAS
16 anal canal adenocarcinoma 9.8 HRAS KRAS
17 ampulla of vater neoplasm 9.7 HRAS KRAS
18 lung adenoid cystic carcinoma 9.7 HRAS KRAS
19 nevus, epidermal 9.7 HRAS KRAS
20 acneiform dermatitis 9.7 HRAS KRAS
21 integumentary system cancer 9.7 CEACAM5 HRAS
22 colloid carcinoma of the pancreas 9.7 HRAS KRAS
23 mixed cell type cancer 9.7 HRAS KRAS
24 cystadenocarcinoma 9.7 CEACAM5 HRAS
25 adenosquamous cell lung carcinoma 9.7 HRAS KRAS
26 adenosquamous pancreas carcinoma 9.7 HRAS KRAS
27 core binding factor acute myeloid leukemia 9.7 HRAS KRAS
28 biliary tract neoplasm 9.7 HRAS KRAS
29 duodenum cancer 9.7 HRAS KRAS
30 liver angiosarcoma 9.7 HRAS KRAS
31 lacrimal gland adenocarcinoma 9.7 HRAS KRAS
32 cecum adenocarcinoma 9.7 HRAS KRAS
33 pulmonic stenosis 9.7 HRAS KRAS
34 costello syndrome 9.7 HRAS KRAS
35 skin squamous cell carcinoma 9.7 HRAS KRAS
36 exanthem 9.6 HRAS KRAS
37 lung benign neoplasm 9.6 HRAS KRAS
38 cardiofaciocutaneous syndrome 1 9.6 HRAS KRAS
39 colorectal adenoma 9.6 HRAS KRAS
40 adamantinoma of long bones 9.6 CEACAM5 KRAS
41 differentiated thyroid carcinoma 9.6 HRAS KRAS
42 pilocytic astrocytoma 9.5 HRAS KRAS
43 thyroid cancer, nonmedullary, 2 9.5 CEACAM5 HRAS
44 autoimmune lymphoproliferative syndrome 9.5 HRAS KRAS
45 bladder urothelial carcinoma 9.5 HRAS KRAS
46 noonan syndrome 1 9.4 HRAS KRAS
47 adenoid cystic carcinoma 9.4 HRAS KRAS
48 apocrine adenoma 9.2 CEACAM5 HRAS KRAS
49 aggressive digital papillary adenocarcinoma 9.2 CEACAM5 HRAS KRAS
50 ovary serous adenocarcinoma 9.2 CEACAM5 HRAS KRAS

Graphical network of the top 20 diseases related to Sigmoid Neoplasm:



Diseases related to Sigmoid Neoplasm

Symptoms & Phenotypes for Sigmoid Neoplasm

GenomeRNAi Phenotypes related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.73 HRAS KRAS
2 Decreased viability GR00106-A-0 9.73 KRAS
3 Decreased viability GR00221-A-1 9.73 KRAS HRAS
4 Decreased viability GR00221-A-2 9.73 KRAS HRAS
5 Decreased viability GR00221-A-3 9.73 HRAS
6 Decreased viability GR00301-A 9.73 KRAS
7 Decreased viability GR00381-A-1 9.73 KRAS
8 Decreased viability GR00402-S-2 9.73 KRAS HRAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.47 KRAS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.47 KRAS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.47 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.47 HRAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.47 KRAS HRAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.47 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.47 HRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.47 KRAS
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.47 KRAS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 KRAS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.47 HRAS
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.47 KRAS

Drugs & Therapeutics for Sigmoid Neoplasm

Drugs for Sigmoid Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 4,Phase 2,Not Applicable
2
Udenafil Approved, Investigational Phase 2 268203-93-6 6918523
3 Phosphodiesterase 5 Inhibitors Phase 2
4 Phosphodiesterase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL) Not yet recruiting NCT03083951 Phase 4
2 Efficacy of Udenafil After Radical Resection for Sigmoid Colon and Rectal Cancer Completed NCT00607282 Phase 2 Udenafil
3 A Study of Perfusion of Colorectal Anastomosis Using Fluorescence Angiography Recruiting NCT03390517 Not Applicable
4 The Effects of Mechnikov Probiotics on Symptom and Surgical Outcome Recruiting NCT03531606 Not Applicable Mechnicov probiotics;Placebo
5 Sigmoid Colon Organ Motion in Radiotherapy Recruiting NCT03259828 Not Applicable
6 Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers Recruiting NCT02222844 Not Applicable
7 Length of Hospital Stay, Nursing Hours and Recovery After Laparoscopic Versus Open Colon Resection Without Fast Track Terminated NCT01127425 Not Applicable

Search NIH Clinical Center for Sigmoid Neoplasm

Cochrane evidence based reviews: sigmoid neoplasms

Genetic Tests for Sigmoid Neoplasm

Anatomical Context for Sigmoid Neoplasm

MalaCards organs/tissues related to Sigmoid Neoplasm:

41
Colon

Publications for Sigmoid Neoplasm

Articles related to Sigmoid Neoplasm:

# Title Authors Year
1
Non-absorbable suture granuloma mimicking a retroperitoneal metastatic implant in a patient with sigmoid neoplasm. ( 27615018 )
2016

Variations for Sigmoid Neoplasm

Expression for Sigmoid Neoplasm

Search GEO for disease gene expression data for Sigmoid Neoplasm.

Pathways for Sigmoid Neoplasm

Pathways related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CEACAM5 HRAS KRAS
2
Show member pathways
11.97 HRAS KRAS
3 11.96 HRAS KRAS
4
Show member pathways
11.96 HRAS KRAS
5
Show member pathways
11.95 HRAS KRAS
6
Show member pathways
11.94 HRAS KRAS
7 11.93 HRAS KRAS
8
Show member pathways
11.92 HRAS KRAS
9 11.91 HRAS KRAS
10
Show member pathways
11.91 HRAS KRAS
11
Show member pathways
11.89 HRAS KRAS
12
Show member pathways
11.88 HRAS KRAS
13
Show member pathways
11.88 HRAS KRAS
14 11.83 HRAS KRAS
15
Show member pathways
11.83 HRAS KRAS
16 11.82 HRAS KRAS
17
Show member pathways
11.82 HRAS KRAS
18
Show member pathways
11.81 HRAS KRAS
19 11.79 HRAS KRAS
20
Show member pathways
11.79 HRAS KRAS
21
Show member pathways
11.78 HRAS KRAS
22 11.77 HRAS KRAS
23
Show member pathways
11.75 HRAS KRAS
24 11.75 HRAS KRAS
25
Show member pathways
11.74 HRAS KRAS
26 11.72 HRAS KRAS
27 11.71 HRAS KRAS
28 11.7 HRAS KRAS
29 11.69 HRAS KRAS
30 11.69 HRAS KRAS
31 11.67 HRAS KRAS
32
Show member pathways
11.66 HRAS KRAS
33 11.64 HRAS KRAS
34 11.61 HRAS KRAS
35
Show member pathways
11.57 HRAS KRAS
36
Show member pathways
11.55 HRAS KRAS
37 11.54 HRAS KRAS
38
Show member pathways
11.5 HRAS KRAS
39 11.44 HRAS KRAS
40 11.38 HRAS KRAS
41 11.37 HRAS KRAS
42
Show member pathways
11.36 HRAS KRAS
43 11.31 HRAS KRAS
44 11.27 HRAS KRAS
45 11.19 HRAS KRAS
46 11.12 HRAS KRAS
47
Show member pathways
11.05 CEACAM5 HRAS KRAS
48 11.03 HRAS KRAS
49 11.01 HRAS KRAS
50 10.93 HRAS KRAS

GO Terms for Sigmoid Neoplasm

Biological processes related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Fc-epsilon receptor signaling pathway GO:0038095 9.49 HRAS KRAS
2 positive regulation of protein phosphorylation GO:0001934 9.48 HRAS KRAS
3 negative regulation of neuron apoptotic process GO:0043524 9.46 HRAS KRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 HRAS KRAS
5 Ras protein signal transduction GO:0007265 9.4 HRAS KRAS
6 positive regulation of MAP kinase activity GO:0043406 9.37 HRAS KRAS
7 epidermal growth factor receptor signaling pathway GO:0007173 9.32 HRAS KRAS
8 ERBB2 signaling pathway GO:0038128 9.26 HRAS KRAS
9 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 HRAS KRAS
10 leukocyte migration GO:0050900 9.13 CEACAM5 HRAS KRAS
11 response to isolation stress GO:0035900 8.62 HRAS KRAS

Molecular functions related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 HRAS KRAS

Sources for Sigmoid Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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