MCID: SGM002
MIFTS: 26

Sigmoid Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Sigmoid Neoplasm

MalaCards integrated aliases for Sigmoid Neoplasm:

Name: Sigmoid Neoplasm 12 15 17
Sigmoid Neoplasms 43 71
Neoplasm of Sigmoid Colon 12
Tumor of Sigmoid Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1896
MeSH 43 D012811
UMLS 71 C0037073

Summaries for Sigmoid Neoplasm

MalaCards based summary : Sigmoid Neoplasm, also known as sigmoid neoplasms, is related to villous adenoma and colon leiomyosarcoma. An important gene associated with Sigmoid Neoplasm is APOLD1 (Apolipoprotein L Domain Containing 1). The drugs Udenafil and Phosphodiesterase 5 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include colon and liver.

Related Diseases for Sigmoid Neoplasm

Diseases related to Sigmoid Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 villous adenoma 10.3 CEACAM5 APOLD1
2 colon leiomyosarcoma 10.3 CEACAM5 APOLD1
3 rectum signet ring adenocarcinoma 10.3 CEACAM5 APOLD1
4 ascending colon cancer 10.2 CEACAM5 APOLD1
5 ovarian squamous cell carcinoma 10.2 CEACAM5 APOLD1
6 large intestine lipoma 10.2 CEACAM5 APOLD1
7 colon sarcoma 10.2 CEACAM5 APOLD1
8 lipoma of colon 10.2 CEACAM5 APOLD1
9 rectosigmoid cancer 10.2 CEACAM5 APOLD1
10 hemorrhoid 10.2 CEACAM5 APOLD1
11 rectal disease 10.1 CEACAM5 APOLD1
12 myoblastoma 10.1 CEACAM6 CEACAM5
13 anal canal adenocarcinoma 10.0 KRT7 APOLD1
14 benign mesenchymoma 10.0 KRT7 APOLD1
15 urethral villous adenoma 9.9 KRT7 CEACAM5
16 malignant spiradenoma 9.9 KRT7 CEACAM5
17 ureter adenocarcinoma 9.9 KRT7 CEACAM5
18 cutaneous mucoepidermoid carcinoma 9.9 KRT7 CEACAM5
19 seminal vesicle adenocarcinoma 9.9 KRT7 CEACAM5
20 pancreatic foamy gland adenocarcinoma 9.9 KRT7 CEACAM5
21 mucinous adenofibroma 9.9 KRT7 CEACAM5
22 aortic malignant tumor 9.9 KRT7 CEACAM5
23 urinary bladder villous adenoma 9.9 KRT7 CEACAM5
24 apocrine adenoma 9.9 KRT7 CEACAM5
25 vulval paget's disease 9.9 KRT7 CEACAM5
26 mucinous intrahepatic cholangiocarcinoma 9.9 KRT7 CEACAM5
27 eccrine adenocarcinoma 9.9 KRT7 CEACAM5
28 renal pelvis adenocarcinoma 9.9 KRT7 CEACAM5
29 external ear carcinoma 9.9 KRT7 CEACAM5
30 bile duct cystadenocarcinoma 9.9 KRT7 CEACAM5
31 cystadenocarcinoma 9.9 KRT7 CEACAM5
32 anal paget's disease 9.9 KRT7 CEACAM5
33 vulva adenocarcinoma 9.9 KRT7 CEACAM5
34 colonic lymphangioma 9.9 KRT7 CEACAM5
35 jejunal adenocarcinoma 9.9 KRT7 CEACAM5
36 krukenberg carcinoma 9.9 KRT7 CEACAM5
37 vaginal tubulovillous adenoma 9.9 KRT7 CEACAM5
38 female urethral cancer 9.9 KRT7 CEACAM5
39 vulvar apocrine adenocarcinoma 9.9 KRT7 CEACAM5
40 vaginal adenoma 9.9 KRT7 CEACAM5
41 mucinous ovarian cystadenoma 9.9 KRT7 CEACAM5
42 ovarian cystadenoma 9.9 KRT7 CEACAM5
43 cystadenoma 9.9 KRT7 CEACAM5
44 appendiceal neoplasm 9.9 KRT7 CEACAM5
45 eccrine papillary adenocarcinoma 9.9 KRT7 CEACAM5
46 papillary adenocarcinoma 9.9 KRT7 CEACAM5
47 malignant syringoma 9.9 KRT7 CEACAM5
48 intestinal benign neoplasm 9.9 CEACAM5 APOLD1
49 syringoma 9.9 KRT7 CEACAM5
50 biliary papillomatosis 9.9 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Sigmoid Neoplasm:



Diseases related to Sigmoid Neoplasm

Symptoms & Phenotypes for Sigmoid Neoplasm

Drugs & Therapeutics for Sigmoid Neoplasm

Drugs for Sigmoid Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Udenafil Approved, Investigational Phase 2 268203-93-6 6918523
2 Phosphodiesterase 5 Inhibitors Phase 2
3 Phosphodiesterase Inhibitors Phase 2
4 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Udenafil in Treatment of Erectile Dysfunction After Radical Resection for Sigmoid Colon and Rectal Cancer : a Randomized Controlled Trial Completed NCT00607282 Phase 2 Udenafil
2 A Study of Perfusion of Colorectal Anastomosis Using FLuorescence AnGiography (FLAG-trial) Completed NCT03390517
3 The Effects of Mechnikov Probiotics on Symptom and Surgical Outcome After Anterior Resection of Colon Cancer; Double-blind, Randomized, Placebo-controlled Trial Completed NCT03531606 Mechnicov probiotics;Placebo
4 Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers Recruiting NCT02222844
5 Interfraction and Intrafraction Organ Motion of the Sigmoid Colon in Patients With Colorectal Cancer Undergoing Adjuvant Radiotherapy Recruiting NCT03259828
6 Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL) Active, not recruiting NCT03083951
7 Five Year Oncological Outcome After Complete Mesocolic Excision for Sigmoid Colon Cancer: a Population-based Cohort Study Active, not recruiting NCT03774134
8 Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery - A Single-center Feasibility Pilot Study. Not yet recruiting NCT03628248
9 Length of Hospital Stay, Nursing Hours and Recovery After Laparoscopic Versus Open Colon Resection Without Fast Track Terminated NCT01127425

Search NIH Clinical Center for Sigmoid Neoplasm

Cochrane evidence based reviews: sigmoid neoplasms

Genetic Tests for Sigmoid Neoplasm

Anatomical Context for Sigmoid Neoplasm

MalaCards organs/tissues related to Sigmoid Neoplasm:

40
Colon, Liver

Publications for Sigmoid Neoplasm

Articles related to Sigmoid Neoplasm:

(show all 14)
# Title Authors PMID Year
1
Management of Malignant Large-Bowel Obstruction. 61
31397752 2019
2
Non-absorbable suture granuloma mimicking a retroperitoneal metastatic implant in a patient with sigmoid neoplasm. 61
27615018 2016
3
A Case Report of Long-Term Survival following Hepatic Arterial Infusion of L-Folinic Acid Modulated 5-Fluorouracil Combined with Intravenous Irinotecan and Cetuximab Followed by Hepatectomy in a Patient with Initially Unresectable Colorectal Liver Metastases. 61
26064730 2015
4
New technique of intracorporeal anastomosis and transvaginal specimen extraction for laparoscopic sigmoid colectomy. 61
25169517 2014
5
Clinical correlates of health preference and generic health-related quality of life in patients with colorectal neoplasms. 61
23516465 2013
6
Inflammatory myofibroblastic tumor of the liver in an elderly woman following a second liver biopsy: a case report. 61
22111473 2011
7
Diseases that simulate acute appendicitis on ultrasound. 61
9534708 1998
8
[A rare case of coexistence of aneurysm of the abdominal aorta and sigmoid neoplasm]. 61
1295242 1992
9
Surgical procedures in colorectal cancer emergencies. 61
3201149 1988
10
[Acquired B antigen in a patient with a sigmoid neoplasm. The role of a pyocyanic bacterium?]. 61
7166997 1982
11
[Sigmoid neoplasms in patients with ureterosigmoidostomy]. 61
6275255 1981
12
[Indications and results in the author's own surgical experience of recto-sigmoid neoplasms]. 61
5499262 1970
13
[Ulcerative colitis secondary to partial stenosing sigmoid neoplasm]. 61
5739401 1968
14
[The abdominal route in the surgical treatment of recto-sigmoid neoplasms]. 61
15442359 1950

Variations for Sigmoid Neoplasm

Expression for Sigmoid Neoplasm

Search GEO for disease gene expression data for Sigmoid Neoplasm.

Pathways for Sigmoid Neoplasm

GO Terms for Sigmoid Neoplasm

Biological processes related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.16 CEACAM6 CEACAM5
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.13 CEACAM6 CEACAM5 CDHR4
3 negative regulation of anoikis GO:2000811 8.62 CEACAM6 CEACAM5

Sources for Sigmoid Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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