MCID: SGM002
MIFTS: 32

Sigmoid Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Sigmoid Neoplasm

MalaCards integrated aliases for Sigmoid Neoplasm:

Name: Sigmoid Neoplasm 12 15 17
Sigmoid Neoplasms 45 74
Neoplasm of Sigmoid Colon 12
Tumor of Sigmoid Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1896
MeSH 45 D012811
UMLS 74 C0037073

Summaries for Sigmoid Neoplasm

MalaCards based summary : Sigmoid Neoplasm, also known as sigmoid neoplasms, is related to melanotic medulloblastoma and atypical follicular adenoma. An important gene associated with Sigmoid Neoplasm is ENO2 (Enolase 2), and among its related pathways/superpathways are Fc-GammaR Pathway and Signaling by PTK6. The drugs Cola and Udenafil have been mentioned in the context of this disorder. Affiliated tissues include colon, thyroid and pancreas.

Related Diseases for Sigmoid Neoplasm

Diseases related to Sigmoid Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 melanotic medulloblastoma 10.1 CEACAM5 ENO2
2 atypical follicular adenoma 10.1 CEACAM5 ENO2
3 rete testis adenocarcinoma 10.1 CEACAM5 ENO2
4 gastric small cell carcinoma 10.1 CEACAM5 ENO2
5 mucinous ovarian cystadenoma 10.1 CEACAM5 ENO2
6 breast adenomyoepithelioma 10.1 CEACAM5 ENO2
7 breast myoepithelial neoplasm 10.1 CEACAM5 ENO2
8 rete testis neoplasm 10.1 CEACAM5 ENO2
9 chondroid chordoma 10.1 CEACAM5 ENO2
10 congenital epulis 10.1 CEACAM5 ENO2
11 mixed ductal-endocrine carcinoma 10.1 CEACAM5 ENO2
12 urachal adenocarcinoma 10.1 CEACAM5 KRAS
13 pancreatic cystadenocarcinoma 10.1 CEACAM5 KRAS
14 tracheal cancer 10.1 CEACAM5 ENO2
15 colonic benign neoplasm 10.1 CEACAM5 KRAS
16 respiratory system benign neoplasm 10.0 ENO2 KRAS
17 large cell carcinoma 10.0 CEACAM5 ENO2
18 ovarian cancer 1 10.0 CEACAM5 KRAS
19 malignant ectomesenchymoma 10.0 ENO2 HRAS
20 ectomesenchymoma 10.0 ENO2 HRAS
21 cystadenocarcinoma 9.9 CEACAM5 HRAS
22 fetal adenoma 9.9 CEACAM5 HRAS
23 prostate squamous cell carcinoma 9.9 CEACAM5 HRAS
24 meningeal melanomatosis 9.9 ENO2 HRAS
25 pancreatic mucinous cystadenoma 9.9 CEACAM5 HRAS
26 periampullary adenoma 9.9 HRAS KRAS
27 paronychia 9.9 HRAS KRAS
28 schimmelpenning-feuerstein-mims syndrome 9.9 HRAS KRAS
29 central nervous system melanocytic neoplasm 9.9 ENO2 HRAS
30 bile duct cysts 9.9 HRAS KRAS
31 appendix disease 9.9 HRAS KRAS
32 lung adenoid cystic carcinoma 9.9 HRAS KRAS
33 nasal cavity adenocarcinoma 9.9 HRAS KRAS
34 secondary hypertrophic osteoarthropathy 9.9 HRAS KRAS
35 anal canal adenocarcinoma 9.9 HRAS KRAS
36 gastrointestinal stromal tumor 9.9
37 perivascular epithelioid cell tumor 9.9
38 skin benign neoplasm 9.9 ENO2 HRAS
39 ovarian cystadenocarcinoma 9.9 HRAS KRAS
40 acneiform dermatitis 9.9 HRAS KRAS
41 colloid carcinoma of the pancreas 9.9 HRAS KRAS
42 hemangioma 9.9 ENO2 KRAS
43 core binding factor acute myeloid leukemia 9.8 HRAS KRAS
44 mucinous lung adenocarcinoma 9.8 HRAS KRAS
45 cecum adenocarcinoma 9.8 HRAS KRAS
46 costello syndrome 9.8 HRAS KRAS
47 ampulla of vater cancer 9.8 HRAS KRAS
48 exanthem 9.8 HRAS KRAS
49 pulmonic stenosis 9.8 HRAS KRAS
50 small intestine cancer 9.8 HRAS KRAS

Graphical network of the top 20 diseases related to Sigmoid Neoplasm:



Diseases related to Sigmoid Neoplasm

Symptoms & Phenotypes for Sigmoid Neoplasm

Drugs & Therapeutics for Sigmoid Neoplasm

Drugs for Sigmoid Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 4,Phase 2,Not Applicable
2
Udenafil Approved, Investigational Phase 2 268203-93-6 6918523
3 Phosphodiesterase Inhibitors Phase 2
4 Phosphodiesterase 5 Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL) Not yet recruiting NCT03083951 Phase 4
2 Efficacy of Udenafil After Radical Resection for Sigmoid Colon and Rectal Cancer Completed NCT00607282 Phase 2 Udenafil
3 The Effects of Mechnikov Probiotics on Symptom and Surgical Outcome Completed NCT03531606 Not Applicable Mechnicov probiotics;Placebo
4 A Study of Perfusion of Colorectal Anastomosis Using FLuorescence AnGiography (FLAG-trial) Recruiting NCT03390517 Not Applicable
5 Sigmoid Colon Organ Motion in Radiotherapy Recruiting NCT03259828 Not Applicable
6 Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers Recruiting NCT02222844 Not Applicable
7 Five Year Oncological Outcome After CME for Sigmoid Colon Cancer Active, not recruiting NCT03774134
8 Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery Not yet recruiting NCT03628248 Not Applicable
9 Length of Hospital Stay, Nursing Hours and Recovery After Laparoscopic Versus Open Colon Resection Without Fast Track Terminated NCT01127425 Not Applicable

Search NIH Clinical Center for Sigmoid Neoplasm

Cochrane evidence based reviews: sigmoid neoplasms

Genetic Tests for Sigmoid Neoplasm

Anatomical Context for Sigmoid Neoplasm

MalaCards organs/tissues related to Sigmoid Neoplasm:

42
Colon, Thyroid, Pancreas, Ovary, Testis, Liver, Small Intestine

Publications for Sigmoid Neoplasm

Articles related to Sigmoid Neoplasm:

# Title Authors Year
1
Non-absorbable suture granuloma mimicking a retroperitoneal metastatic implant in a patient with sigmoid neoplasm. ( 27615018 )
2016

Variations for Sigmoid Neoplasm

Expression for Sigmoid Neoplasm

Search GEO for disease gene expression data for Sigmoid Neoplasm.

Pathways for Sigmoid Neoplasm

Pathways related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 HRAS KRAS
2
Show member pathways
11.78 HRAS KRAS
3 11.77 HRAS KRAS
4
Show member pathways
11.75 HRAS KRAS
5 11.74 HRAS KRAS
6 11.73 HRAS KRAS
7 11.71 HRAS KRAS
8 11.7 HRAS KRAS
9 11.7 HRAS KRAS
10 11.69 HRAS KRAS
11 11.67 HRAS KRAS
12
Show member pathways
11.66 HRAS KRAS
13 11.62 HRAS KRAS
14 11.61 HRAS KRAS
15
Show member pathways
11.57 HRAS KRAS
16
Show member pathways
11.55 HRAS KRAS
17 11.54 HRAS KRAS
18
Show member pathways
11.5 HRAS KRAS
19 11.44 HRAS KRAS
20 11.38 HRAS KRAS
21 11.37 HRAS KRAS
22
Show member pathways
11.36 HRAS KRAS
23 11.31 HRAS KRAS
24 11.28 HRAS KRAS
25 11.19 HRAS KRAS
26 11.13 HRAS KRAS
27
Show member pathways
11.05 CEACAM5 HRAS KRAS
28 11.02 HRAS KRAS
29 11.01 HRAS KRAS
30 10.93 HRAS KRAS
31 10.91 HRAS KRAS
32
Show member pathways
10.87 HRAS KRAS
33
Show member pathways
10.78 HRAS KRAS
34 10.68 HRAS KRAS
35 10.6 HRAS KRAS
36 10.46 HRAS KRAS
37 10.07 HRAS KRAS

GO Terms for Sigmoid Neoplasm

Biological processes related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.32 HRAS KRAS
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 HRAS KRAS
3 positive regulation of MAP kinase activity GO:0043406 9.16 HRAS KRAS
4 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 HRAS KRAS
5 response to isolation stress GO:0035900 8.62 HRAS KRAS

Molecular functions related to Sigmoid Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 HRAS KRAS

Sources for Sigmoid Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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