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MCID: SGN002
MIFTS: 40

Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Signet Ring Cell Adenocarcinoma

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MalaCards integrated aliases for Signet Ring Cell Adenocarcinoma:

Name: Signet Ring Cell Adenocarcinoma 12 15
Carcinoma, Signet Ring Cell 44 73
Signet Ring Cell Carcinoma 12
Carcinoma Signet Ring Cell 55
Signet Ring Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
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External Ids:

Disease Ontology 12 DOID:3493
MeSH 44 D018279
NCIt 50 C3774
SNOMED-CT 68 87737001
UMLS 73 C0206696
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Summaries for Signet Ring Cell Adenocarcinoma

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Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which have signet ring appearance.

MalaCards based summary : Signet Ring Cell Adenocarcinoma, also known as carcinoma, signet ring cell, is related to gastric signet ring cell adenocarcinoma and krukenberg carcinoma. An important gene associated with Signet Ring Cell Adenocarcinoma is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are O-linked glycosylation and Cytoskeletal Signaling. The drugs Fluorouracil and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include prostate, lung and appendix.

Wikipedia : 76 Signet ring cell carcinoma (SRCC) is a rare form of highly malignant adenocarcinoma that produces mucin.... more...

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Related Diseases for Signet Ring Cell Adenocarcinoma

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Diseases related to Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 gastric signet ring cell adenocarcinoma 34.3 CDH1 CDX2
2 krukenberg carcinoma 32.9 KRT20 KRT7
3 microinvasive gastric cancer 30.7 CDH1 CDX2 MUC2
4 rectum adenocarcinoma 30.5 CDX2 KRT20 KRT7
5 linitis plastica 30.5 CDH1 KRT20 KRT7
6 mucinous adenocarcinoma 30.5 CDX2 KRT20 KRT7 MUC1 MUC2
7 small cell carcinoma 30.4 CHGA KRT20 KRT7
8 granulosa cell tumor of the ovary 30.3 CHGA KRT7
9 bladder urothelial carcinoma 30.2 CDH1 KRT20 KRT7
10 eyelid carcinoma 30.2 KRT20 KRT7 MUC2
11 neuroendocrine tumor 30.1 CHGA KRT20 KRT7
12 solid adenocarcinoma with mucin production 30.1 KRT7 MUC1 MUC6
13 gastric cancer 29.9 CDH1 CDX2 KRT20 MUC2 MUC6
14 tubular adenocarcinoma 29.9 CDH1 CDX2 CHGA KRT20 MUC1 MUC2
15 colorectal adenocarcinoma 29.9 CDH1 CDX2 KRT20 KRT7 MUC2
16 intrahepatic cholangiocarcinoma 29.6 CDH1 CDX2 KRT20 KRT7 MUC1 MUC2
17 cholangiocarcinoma 29.6 CDH1 CDX2 KRT20 KRT7 MUC1 MUC2
18 gastric adenocarcinoma 29.6 CDH1 CDX2 CHGA KRT20 KRT7 MUC1
19 bladder signet ring cell adenocarcinoma 12.6
20 bile duct signet ring cell carcinoma 12.5
21 gallbladder signet ring cell adenocarcinoma 12.4
22 breast signet ring cell adenocarcinoma 12.4
23 prostate signet ring cell adenocarcinoma 12.4
24 pancreatic signet ring cell adenocarcinoma 12.4
25 ampullary signet ring cell adenocarcinoma 12.4
26 rectum signet ring adenocarcinoma 11.7
27 gastric cancer, hereditary diffuse 11.4
28 prostate cancer 11.3
29 prostate cancer, hereditary, 1 11.3
30 prostate cancer, hereditary, 12 11.3
31 prostate cancer, hereditary, 13 11.3
32 prostate cancer, hereditary, 11 11.3
33 prostate cancer, hereditary, 2 11.3
34 diffuse gastric cancer 11.3
35 adenocarcinoma 11.0
36 immune system organ benign neoplasm 10.3 KRT20 KRT7
37 eccrine sweat gland neoplasm 10.3 KRT20 KRT7
38 thymus lipoma 10.3 KRT20 KRT7
39 medulloepithelioma 10.3 KRT20 KRT7
40 renal pelvis carcinoma 10.3 KRT20 KRT7
41 ovarian cystic teratoma 10.3 KRT20 KRT7
42 glycogen-rich clear cell breast carcinoma 10.3 KRT20 KRT7
43 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 CDX2 MUC2
44 cervical adenosquamous carcinoma 10.3 KRT7 MUC6
45 anus cancer 10.3 CDX2 KRT7
46 anal canal adenocarcinoma 10.3 CDX2 KRT7
47 nasal cavity adenocarcinoma 10.3 CDX2 KRT7
48 corneal dystrophy, posterior polymorphous, 3 10.3 CDH1 KRT7
49 breast adenomyoepithelioma 10.3 CDH1 KRT7
50 breast myoepithelial neoplasm 10.3 CDH1 KRT7

Graphical network of the top 20 diseases related to Signet Ring Cell Adenocarcinoma:



Diseases related to Signet Ring Cell Adenocarcinoma
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Symptoms & Phenotypes for Signet Ring Cell Adenocarcinoma

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Drugs & Therapeutics for Signet Ring Cell Adenocarcinoma

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Drugs for Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3 51-21-8 3385
2
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
3
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
4
Irinotecan Approved, Investigational Phase 3 100286-90-6, 97682-44-5 60838
5
leucovorin Approved Phase 3 58-05-9 6006 143
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
7
Bevacizumab Approved, Investigational Phase 3 216974-75-3
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
9
Camptothecin Experimental Phase 3 7689-03-4
10 Micronutrients Phase 3
11 Immunosuppressive Agents Phase 3
12 Vitamin B Complex Phase 3
13 Trace Elements Phase 3
14 Vitamin B9 Phase 3
15 Calcium, Dietary Phase 3
16 Vitamins Phase 3
17 Antineoplastic Agents, Phytogenic Phase 3
18 topoisomerase I inhibitors Phase 3
19 Immunologic Factors Phase 3,Phase 2,Phase 1
20 Antidotes Phase 3
21 Antimetabolites Phase 3,Phase 2
22 Bone Density Conservation Agents Phase 3
23 Topoisomerase Inhibitors Phase 3
24 Antimetabolites, Antineoplastic Phase 3,Phase 2
25 Folate Phase 3
26 Protective Agents Phase 3
27 Cola Phase 3,Phase 1,Phase 2
28 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
29 Antibodies Phase 3,Phase 2,Phase 1
30 Immunoglobulins Phase 3,Phase 2,Phase 1
31 Angiogenesis Inhibitors Phase 3
32 Immunoglobulin G Phase 3
33 Angiogenesis Modulating Agents Phase 3
34 Hematinics Phase 3
35 Endothelial Growth Factors Phase 3
36 Mitogens Phase 3
37
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
38
Nivolumab Approved Phase 2 946414-94-4
39
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
40
Turmeric Approved, Experimental, Investigational Phase 2
41 Anti-Bacterial Agents Phase 1, Phase 2
42 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
43 Antibiotics, Antitubercular Phase 1, Phase 2
44 Alkylating Agents Phase 1, Phase 2
45 Mitomycins Phase 1, Phase 2
46 Anti-Inflammatory Agents Phase 2
47 Turmeric extract Phase 2
48 Anti-Inflammatory Agents, Non-Steroidal Phase 2
49 Analgesics Phase 2
50 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer Completed NCT00068692 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin;Irinotecan
2 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
3 XELOX Plus Apatinib vs XELOX as Post-operative Chemotherapy in Locally Advanced Gastric Signet Ring Carcinoma Not yet recruiting NCT03355612 Phase 3 Apatinib;XELOX
4 Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients Completed NCT02575859 Phase 1, Phase 2 adjuvant HIPEC
5 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
6 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
7 Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer Active, not recruiting NCT00745134 Phase 2 Capecitabine
8 QUILT-3.017: Study of NEO-201 in Solid Tumors Recruiting NCT03476681 Phase 1 NEO-201
9 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
10 Prognosis of Signet Ring Cells in Upper Digestive Neoplasms Completed NCT01249859
11 Signet Ring Cell Carcinoma in Esophageal Adenocarcinoma Completed NCT01824966
12 NBI for Identifying Resection Margin Status in Gastric Cancer Completed NCT02926716
13 Socioeconomic Position in Acute Colorectal Cancer Surgery Active, not recruiting NCT03581890

Search NIH Clinical Center for Signet Ring Cell Adenocarcinoma

Cochrane evidence based reviews: carcinoma, signet ring cell

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Genetic Tests for Signet Ring Cell Adenocarcinoma

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Anatomical Context for Signet Ring Cell Adenocarcinoma

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MalaCards organs/tissues related to Signet Ring Cell Adenocarcinoma:

41
Prostate, Lung, Appendix, Colon, Pancreas, Thymus, Small Intestine
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Publications for Signet Ring Cell Adenocarcinoma

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Articles related to Signet Ring Cell Adenocarcinoma:

(show top 50) (show all 81)
# Title Authors Year
1
Diffuse-type Gastric Mucinous and Signet Ring Cell Adenocarcinoma in a Captive California King Snake (Lampropeltis getula californiae). ( 29729716 )
2018
2
Dystrophic Adipocytes Mimicking Metastatic Signet Ring Cell Adenocarcinoma: A Diagnostic Pitfall in a Cachectic Patient. ( 29854530 )
2018
3
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. ( 29801472 )
2018
4
Treatment of a pediatric patient with MET-amplified signet ring cell adenocarcinoma of the stomach with crizotinib. ( 29380521 )
2018
5
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma. ( 30333909 )
2018
6
Primary Thymic Signet Ring Cell Adenocarcinoma: A Currently Unrecognized Variant. ( 30259765 )
2018
7
Clinicopathological differences in signet ring cell adenocarcinoma between early and advanced gastric cancer. ( 30069742 )
2018
8
Leptomeningeal carcinomatosis in a young patient with obstructive colorectal signet- ring cell adenocarcinoma. ( 28530107 )
2017
9
Peritoneal carcinomatosis from signet-ring cell adenocarcinoma of the appendix. ( 28322773 )
2017
10
Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. ( 28326211 )
2017
11
The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus. ( 29212656 )
2017
12
Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature. ( 29375924 )
2017
13
Pulmonary Signet-Ring Cell Adenocarcinoma Metastatic to the Skin. ( 27898475 )
2016
14
A Rare Case of an Adult with Untreated Bladder Exstrophy Presenting with Signet-Ring Cell Adenocarcinoma of Urinary Bladder. ( 28050437 )
2016
15
Primary signet ring cell adenocarcinoma of the uterine cervix - A rare neoplasm that raises the question of metastasis to the cervix. ( 27331127 )
2016
16
A rare case of metastatic germ cell tumor to stomach and duodenum masquerading as signet ring cell adenocarcinoma. ( 27668229 )
2016
17
Primary signet-ring cell adenocarcinoma of the head and neck: a case study and brief review. ( 27185232 )
2016
18
A Case of Gastric Cancer with Neuroendocrine Carcinoma, Signet Ring Cell Carcinoma Components, and Intramural Metastases. ( 27102318 )
2016
19
Signet Ring Cell Adenocarcinoma and Bilateral Leptomeningeal Involvement of Optic Nerve Sheaths. ( 25839780 )
2015
20
Colonic-type appendiceal adenocarcinoma: an intermediate prognosis between mucinous and signet ring cell adenocarcinoma. ( 26735622 )
2015
21
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
22
A case with primary signet ring cell adenocarcinoma of the prostate and review of the literature. ( 25017602 )
2014
23
Primary Signet Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of 2 Cases. ( 26955554 )
2014
24
The impact of preoperative radiochemotherapy on survival in advanced esophagogastric junction signet ring cell adenocarcinoma. ( 24200394 )
2014
25
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
26
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
27
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
28
Primary signet-ring cell adenocarcinoma of the uterine cervix: case report and review of the literature. ( 24020147 )
2013
29
Metastatic signet ring cell adenocarcinoma of the bladder: responsive to treatment? ( 22396377 )
2012
30
Primary pure signet-ring cell adenocarcinoma of the urinary bladder: a report of three cases with an immunohistochemical study. ( 22120516 )
2012
31
Signet ring cell adenocarcinoma of the ampulla of Vater: a rare patho. ( 23130863 )
2012
32
Interval signet-ring cell adenocarcinoma of the colon: missed or de novo? ( 21540911 )
2011
33
A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation. ( 22022068 )
2011
34
Secondary signet-ring cell adenocarcinoma of urinary bladder from a gastric primary. ( 21747602 )
2011
35
Primary pure signet ring cell adenocarcinoma of non-Barrett's esophagus. ( 22275019 )
2011
36
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
37
An unusual case of signet ring cell adenocarcinoma of the prostate. ( 21797141 )
2011
38
Morphometric distinction of signet-ring cell adenocarcinoma cells from foamy macrophages in gastric endoscopic biopsies. ( 22102070 )
2011
39
Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report. ( 21719143 )
2011
40
Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon. ( 20737376 )
2010
41
Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. ( 20378938 )
2010
42
Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature. ( 20407328 )
2010
43
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
44
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
45
Signet-ring-cell adenocarcinoma of the myocardium presenting as persistent pleural effusions. ( 19772035 )
2009
46
Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. ( 18789486 )
2009
47
Signet ring cell adenocarcinoma of the oropharynx: presentation of a rare case and review of the literature. ( 19446973 )
2009
48
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
49
Metastatic signet ring cell adenocarcinoma of bone marrow with bilateral ovarian masses: a case report. ( 19019234 )
2008
50
Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report. ( 17913950 )
2007
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Variations for Signet Ring Cell Adenocarcinoma

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Expression for Signet Ring Cell Adenocarcinoma

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Search GEO for disease gene expression data for Signet Ring Cell Adenocarcinoma.
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Pathways for Signet Ring Cell Adenocarcinoma

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Pathways related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
O-linked glycosylation 66
Show member pathways
 11.84 MUC1 MUC2 MUC6
2
Cytoskeletal Signaling 4
11.75 CDH1 KRT20 KRT7 MUC1
3
Diseases of glycosylation 66
Show member pathways
 11.66 MUC1 MUC2 MUC6
4
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 66
Show member pathways
 11.37 MUC1 MUC2 MUC6
5
CLEC7A (Dectin-1) signaling 66
Show member pathways
 11.34 MUC1 MUC2 MUC6 SRC
6
E-cadherin signaling in the nascent adherens junction 1
10.95 CDH1 SRC
7
Nectin adhesion pathway 1
10.77 CDH1 SRC
8
E-cadherin signaling in keratinocytes 1
10.54 CDH1 SRC
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GO Terms for Signet Ring Cell Adenocarcinoma

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Cellular components related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC6

Biological processes related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.5 CDH1 COL14A1 SRC
2 maintenance of gastrointestinal epithelium GO:0030277 9.26 MUC2 MUC6
3 entry of bacterium into host cell GO:0035635 9.16 CDH1 SRC
4 O-glycan processing GO:0016266 9.13 MUC1 MUC2 MUC6
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 MUC1 MUC2 MUC6 SRC
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Sources for Signet Ring Cell Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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