Signet Ring Cell Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SGN002 MIFTS: 47	Signet Ring Cell Adenocarcinoma Categories: Cancer diseases
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Aliases & Classifications for Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Signet Ring Cell Adenocarcinoma:

Name: Signet Ring Cell Adenocarcinoma ¹² ¹⁵

Carcinoma, Signet Ring Cell ⁴⁴ ⁷³

Signet Ring Cell Carcinoma ¹²

Carcinoma Signet Ring Cell ⁵⁵

Signet Ring Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3493

MeSH ⁴⁴ D018279

NCIt ⁵⁰ C3774

SNOMED-CT ⁶⁸ 189701002 189702009 87737001

UMLS ⁷³ C0206696

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Summaries for Signet Ring Cell Adenocarcinoma

Disease Ontology : ¹² An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which have signet ring appearance.

MalaCards based summary : Signet Ring Cell Adenocarcinoma, also known as carcinoma, signet ring cell, is related to gastric signet ring cell adenocarcinoma and rectum adenocarcinoma. An important gene associated with Signet Ring Cell Adenocarcinoma is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are fMLP Pathway and Development HGF signaling pathway. The drugs Bevacizumab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and prostate, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Signet Ring Cell Adenocarcinoma

Diseases related to Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)

#	Related Disease	Score	Top Affiliating Genes
1	gastric signet ring cell adenocarcinoma	34.6	CDH1 CDX2
2	rectum adenocarcinoma	30.9	CDX2 KRT20 KRT7
3	linitis plastica	30.8	CDH1 KRT20 KRT7
4	ethmoid sinusitis	30.3	MUC1 MUC2 MUC6
5	colon adenocarcinoma	30.1	CDH1 CTNNB1 KRT20
6	adenocarcinoma	29.6	CDH1 CTNNB1 MUC1 TP53
7	bladder signet ring cell adenocarcinoma	12.5
8	bile duct signet ring cell carcinoma	12.4
9	gallbladder signet ring cell adenocarcinoma	12.3
10	breast signet ring cell adenocarcinoma	12.3
11	prostate signet ring cell adenocarcinoma	12.3
12	pancreatic signet ring cell adenocarcinoma	12.2
13	ampullary signet ring cell adenocarcinoma	12.2
14	rectum signet ring adenocarcinoma	11.6
15	gastric cancer, hereditary diffuse	11.3
16	diffuse gastric cancer	11.2
17	cystic basal cell carcinoma	10.9	KRT20 KRT7
18	seminal vesicle adenocarcinoma	10.9	KRT20 KRT7
19	transverse colon cancer	10.9	KRT20 KRT7
20	eyelid neoplasm	10.9	KRT20 KRT7
21	malignant syringoma	10.8	KRT20 KRT7
22	krukenberg carcinoma	10.8	KRT20 KRT7
23	ovary neuroendocrine neoplasm	10.8	CDX2 KRT7
24	vulval paget's disease	10.8	KRT20 KRT7
25	intratubular embryonal carcinoma	10.8	KRT20 KRT7
26	mucinous adenofibroma	10.8	CDX2 KRT7
27	anus adenocarcinoma	10.8	CDX2 KRT7
28	meibomian cyst	10.7	KRT20 KRT7
29	endocervical carcinoma	10.7	KRT7 MUC6
30	adenoma of the pancreas	10.7	CHGA KRT20
31	bladder lymphoma	10.7	KRT20 KRT7
32	diversion colitis	10.7	CDH1 MUC2
33	renal pelvis adenocarcinoma	10.7	CDH1 KRT7
34	medulloepithelioma	10.7	KRT20 KRT7
35	epithelial predominant wilms' tumor	10.7	CDX2 KRT7
36	morpheaform basal cell carcinoma	10.7	CDH1 KRT20
37	renal pelvis carcinoma	10.7	KRT20 KRT7
38	chronic cholangitis	10.7	CDX2 MUC2
39	bronchiolo-alveolar adenocarcinoma	10.7	CDX2 KRT7
40	anal canal adenocarcinoma	10.6	CDX2 KRT7
41	pancreatic serous cystadenoma	10.6	CHGA KRT7
42	solid adenocarcinoma with mucin production	10.6	KRT7 MUC1
43	endosalpingiosis	10.5	KRT7 MUC1
44	appendix adenocarcinoma	10.5	CDX2 KRT20 KRT7
45	parachordoma	10.5	KRT7 MUC1
46	glandular cystitis	10.5	CDX2 KRT20 KRT7
47	middle ear adenoma	10.5	KRT7 MUC1
48	polyposis, skin pigmentation, alopecia, and fingernail changes	10.5	CDX2 MUC2
49	thymus adenocarcinoma	10.5	CDX2 KRT20 KRT7
50	jejunal adenocarcinoma	10.5	CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Signet Ring Cell Adenocarcinoma:

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Symptoms & Phenotypes for Signet Ring Cell Adenocarcinoma

MGI Mouse Phenotypes related to Signet Ring Cell Adenocarcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.87	CDH1 TUB CDX2 CHGA CTNNB1 MUC2
2	cellular	MP:0005384	9.86	TUB CDH1 CDX2 CTNNB1 KRT7 MUC2
3	endocrine/exocrine gland	MP:0005379	9.76	CDX2 CHGA CTNNB1 MUC2 SRC TP53
4	neoplasm	MP:0002006	9.43	CDX2 CTNNB1 MUC2 SRC TP53 CDH1
5	pigmentation	MP:0001186	8.92	TUB CTNNB1 SRC TP53

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Drugs & Therapeutics for Signet Ring Cell Adenocarcinoma

Drugs for Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 3

216974-75-3

Fluorouracil

Approved

Phase 3

51-21-8

3385

Levoleucovorin

Approved, Investigational

Phase 3

68538-85-2

Oxaliplatin

Approved, Investigational

Phase 3

61825-94-3

5310940 9887054 43805 6857599

Capecitabine

Approved, Investigational

Phase 3

154361-50-9

60953

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

leucovorin

Approved, Nutraceutical

Phase 3

58-05-9

143 6006

Antibodies

Phase 3,Phase 2,Phase 1

Antibodies, Monoclonal

Phase 3,Phase 2,Phase 1

Immunoglobulins

Phase 3,Phase 2,Phase 1

Angiogenesis Inhibitors

Phase 3

Angiogenesis Modulating Agents

Phase 3

Antidotes

Phase 3

Antimetabolites

Phase 3

Antimetabolites, Antineoplastic

Phase 3

Bone Density Conservation Agents

Phase 3

Calcium, Dietary

Phase 3

Endothelial Growth Factors

Phase 3

Hematinics

Phase 3

Immunoglobulin G

Phase 3

Immunosuppressive Agents

Phase 3

Micronutrients

Phase 3

Mitogens

Phase 3

Protective Agents

Phase 3

Trace Elements

Phase 3

Vitamin B Complex

Phase 3

Vitamins

Phase 3

Cola

Nutraceutical

Phase 3,Phase 1,Phase 2

Folate

Nutraceutical

Phase 3

Vitamin B9

Nutraceutical

Phase 3

Cisplatin

Approved

Phase 1, Phase 2

15663-27-1

84093 441203 2767

nivolumab

Approved

Phase 2

946414-94-4

Alkylating Agents

Phase 1, Phase 2

Anti-Bacterial Agents

Phase 1, Phase 2

Antibiotics, Antitubercular

Phase 1, Phase 2

Mitomycins

Phase 1, Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 1, Phase 2

Cetuximab

Approved

Phase 1

205923-56-4

56842117 2333

Interventional clinical trials:

(show all 11)

#	Name	Status	NCT ID	Phase	Drugs
1	Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer	Active, not recruiting	NCT00217737	Phase 3	Fluorouracil;Leucovorin Calcium;Oxaliplatin
2	XELOX Plus Apatinib vs XELOX as Post-operative Chemotherapy in Locally Advanced Gastric Signet Ring Carcinoma	Not yet recruiting	NCT03355612	Phase 3	Apatinib;XELOX
3	Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients	Completed	NCT02575859	Phase 1, Phase 2	adjuvant HIPEC
4	Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers	Recruiting	NCT02978625	Phase 2
5	Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery	Active, not recruiting	NCT01802320	Phase 2	Akt Inhibitor MK2206
6	QUILT-3.017: Study of NEO-201 in Solid Tumors	Not yet recruiting	NCT03476681	Phase 1	NEO-201
7	Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer	Terminated	NCT01198535	Phase 1	Gamma-Secretase Inhibitor RO4929097
8	Prognosis of Signet Ring Cells in Upper Digestive Neoplasms	Completed	NCT01249859
9	Signet Ring Cell Carcinoma in Esophageal Adenocarcinoma	Completed	NCT01824966
10	NBI for Identifying Resection Margin Status in Gastric Cancer	Completed	NCT02926716
11	Socioeconomic Position in Acute Colorectal Cancer Surgery	Active, not recruiting	NCT03581890

Search NIH Clinical Center for Signet Ring Cell Adenocarcinoma

Cochrane evidence based reviews: carcinoma, signet ring cell

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Genetic Tests for Signet Ring Cell Adenocarcinoma

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Anatomical Context for Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Cell Adenocarcinoma:

⁴¹

Colon, Bone, Prostate, Skin, Endothelial, Cervix, Lung

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Publications for Signet Ring Cell Adenocarcinoma

Articles related to Signet Ring Cell Adenocarcinoma:

(show top 50) (show all 78)

#	Title	Authors	Year
1	Diffuse-type Gastric Mucinous and Signet Ring Cell Adenocarcinoma in a Captive California King Snake (Lampropeltis getula californiae). ( 29729716 )	Hsueh C.S....Chang H.W.	2018
2	Dystrophic Adipocytes Mimicking Metastatic Signet Ring Cell Adenocarcinoma: A Diagnostic Pitfall in a Cachectic Patient. ( 29854530 )	Zhang X....Findeis-Hosey J.J.	2018
3	Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. ( 29801472 )	Yoshikawa T....Ogata N.	2018
4	Treatment of a pediatric patient with MET-amplified signet ring cell adenocarcinoma of the stomach with crizotinib. ( 29380521 )	Sabree S....Sato M.	2018
5	Leptomeningeal carcinomatosis in a young patient with obstructive colorectal signet- ring cell adenocarcinoma. ( 28530107 )	Lusilla A....de TomA!s J.	2017
6	Peritoneal carcinomatosis from signet-ring cell adenocarcinoma of the appendix. ( 28322773 )	Khan S.A....Vaughan R.	2017
7	Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. ( 28326211 )	Khan M....Kopetz S.	2017
8	The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus. ( 29212656 )	Bleaney C.W....Ang Y.	2017
9	Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature. ( 29375924 )	Jayarajah U....Goonewardena S.A.S.	2017
10	Pulmonary Signet-Ring Cell Adenocarcinoma Metastatic to the Skin. ( 27898475 )	Boyd A.S.	2016
11	A Rare Case of an Adult with Untreated Bladder Exstrophy Presenting with Signet-Ring Cell Adenocarcinoma of Urinary Bladder. ( 28050437 )	Savalia A.J....Sawant A.	2016
12	Primary signet ring cell adenocarcinoma of the uterine cervix - A rare neoplasm that raises the question of metastasis to the cervix. ( 27331127 )	Cracchiolo B....Heller D.	2016
13	A rare case of metastatic germ cell tumor to stomach and duodenum masquerading as signet ring cell adenocarcinoma. ( 27668229 )	Mazumdar S....Ramadwar M.	2016
14	Primary signet-ring cell adenocarcinoma of the head and neck: a case study and brief review. ( 27185232 )	Islam S....Laugharne D.	2016
15	Signet Ring Cell Adenocarcinoma and Bilateral Leptomeningeal Involvement of Optic Nerve Sheaths. ( 25839780 )	Mbekeani J.N....Dogar M.A.	2015
16	Colonic-type appendiceal adenocarcinoma: an intermediate prognosis between mucinous and signet ring cell adenocarcinoma. ( 26735622 )	Virgilio E....Cavallini M.	2015
17	Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )	Zippi M....Marzano C.	2014
18	A case with primary signet ring cell adenocarcinoma of the prostate and review of the literature. ( 25017602 )	Celik O....Ilbey Y.O.	2014
19	Primary Signet Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of 2 Cases. ( 26955554 )	Boukettaya W....Frikha M.	2014
20	The impact of preoperative radiochemotherapy on survival in advanced esophagogastric junction signet ring cell adenocarcinoma. ( 24200394 )	Bekkar S....Mariette C.	2014
21	Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )	Dittus C....Negroiu A.	2014
22	Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )	Shaaban H....Francis I.	2013
23	Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )	HonorAc C....Mariette C.	2013
24	Primary signet-ring cell adenocarcinoma of the uterine cervix: case report and review of the literature. ( 24020147 )	Kaidar-Person O....Bortnyak-Abdah R.	2013
25	Metastatic signet ring cell adenocarcinoma of the bladder: responsive to treatment? ( 22396377 )	Singh J....Czaykowski P.M.	2012
26	Primary pure signet-ring cell adenocarcinoma of the urinary bladder: a report of three cases with an immunohistochemical study. ( 22120516 )	Terada T.	2012
27	Signet ring cell adenocarcinoma of the ampulla of Vater: a rare patho. ( 23130863 )	Lesquereux-MartA-nez L....Bustamante-Montalvo M.	2012
28	Interval signet-ring cell adenocarcinoma of the colon: missed or de novo? ( 21540911 )	Sweetser S....Ahlquist D.A.	2011
29	A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation. ( 22022068 )	Shringarpure S.S....Mani R.	2011
30	Secondary signet-ring cell adenocarcinoma of urinary bladder from a gastric primary. ( 21747602 )	Sharma P.K....Chatterjee U.	2011
31	Primary pure signet ring cell adenocarcinoma of non-Barrett's esophagus. ( 22275019 )	Terada T.	2011
32	The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )	Messager M....Mariette C.	2011
33	An unusual case of signet ring cell adenocarcinoma of the prostate. ( 21797141 )	Bonetti L.R....Maiorana A.	2011
34	Morphometric distinction of signet-ring cell adenocarcinoma cells from foamy macrophages in gastric endoscopic biopsies. ( 22102070 )	Kram A....Domagala W.	2011
35	Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report. ( 21719143 )	Ohba T....Ichinose Y.	2011
36	Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon. ( 20737376 )	Park K.K....Park Y.W.	2010
37	Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. ( 20378938 )	Busto MartA-n L.A....Busto CastaA+A^n L.	2010
38	Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature. ( 20407328 )	Chebib I....DiFrancesco L.M.	2010
39	Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )	Ioannidis O....Makrantonakis A.	2010
40	Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )	SolA-s-MuA+oz P....MuA+oz-Yague T.	2010
41	Signet-ring-cell adenocarcinoma of the myocardium presenting as persistent pleural effusions. ( 19772035 )	McCarthy P....Scott L.K.	2009
42	Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. ( 18789486 )	Thomas A.A....Hansel D.E.	2009
43	Signet ring cell adenocarcinoma of the oropharynx: presentation of a rare case and review of the literature. ( 19446973 )	Veit J.A....Tesche S.	2009
44	Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )	Kayacan O....Beder S.	2008
45	Metastatic signet ring cell adenocarcinoma of bone marrow with bilateral ovarian masses: a case report. ( 19019234 )	Jain D....Singh T.	2008
46	Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report. ( 17913950 )	Lee F.Y....Wu C.C.	2007
47	Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile. ( 17550327 )	Castillo C....Leroy X.	2007
48	Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )	Kwon M.S....Leem D.H.	2006
49	FDG PET imaging of signet-ring cell adenocarcinoma of the stomach. ( 15647683 )	Buyyounouski M.K....Adler L.P.	2005
50	Primary signet ring cell adenocarcinoma of the bladder. ( 15951737 )	Marino G....Torchio B.	2005

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Genes for Signet Ring Cell Adenocarcinoma

Genes related to Signet Ring Cell Adenocarcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	33.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19102008
2	KRT7	Keratin 7	Protein Coding	31.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11028811
3	KRT20	Keratin 20	Protein Coding	31.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11028811 16488312
4	CDH1	Cadherin 1	Protein Coding	23.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	16948518 15682444 8797891 (more) 19432899 11107048
5	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	23.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CDX2	Caudal Type Homeobox 2	Protein Coding	23.27	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CHGA	Chromogranin A	Protein Coding	17.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	18269581 16344325 9058136
8	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	16.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	15.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	TUB	Tubby Bipartite Transcription Factor	Protein Coding	15.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	TP53	Tumor Protein P53	Protein Coding	14.87	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	CTNNB1	Catenin Beta 1	Protein Coding	14.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Signet Ring Cell Adenocarcinoma

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Expression for Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Cell Adenocarcinoma.

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Pathways for Signet Ring Cell Adenocarcinoma

Pathways related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	fMLP Pathway ⁶⁴ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ CCR3 Pathway in Eosinophils ⁶⁴ CXCR4 Pathway ⁶⁴ Huntington's Disease Pathway ⁶⁴ Internalin Pathway ⁶⁴ Signal transduction Activation of PKC via G-Protein coupled receptor ²² VEGF and S-1P Signaling ⁶⁴	12.77	CDH1 CDX2 CTNNB1 SRC TP53
2	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.53	CDH1 CTNNB1 SRC TP53
3	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.43	CDH1 CDX2 CTNNB1 MUC2 TP53
4	Cytoskeletal Signaling ⁴	12.28	CDH1 KRT20 KRT7 MUC1
5	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.15	MUC1 MUC2 MUC6 SRC
6	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.1	CDH1 CTNNB1 SRC
7	O-linked glycosylation ⁶⁶ Show member pathways O-linked glycosylation of mucins ⁶⁶	12.07	MUC1 MUC2 MUC6
8	Integrated Breast Cancer Pathway ¹	11.99	CDH1 CTNNB1 TP53
9	Diseases of glycosylation ⁶⁶ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁶	11.96	MUC1 MUC2 MUC6
10	Fluid shear stress and atherosclerosis ³⁷	11.91	CTNNB1 SRC TP53
11	Adhesion ⁴	11.85	CDH1 CTNNB1 MUC1
12	G12-G13 in Cellular Signaling ⁶⁴	11.84	CDH1 CTNNB1 SRC
13	Colorectal Cancer Metastasis ⁶⁴	11.84	CDH1 CTNNB1 SRC TP53
14	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	11.84	CDH1 CTNNB1 MUC1 SRC TP53
15	Thyroid hormone signaling pathway ³⁷	11.81	CTNNB1 SRC TP53
16	Glioblastoma Multiforme ⁶⁴	11.78	CTNNB1 SRC TP53
17	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) ⁶⁶ Show member pathways Dectin-2 family ⁶⁶ Defective GALNT12 causes colorectal cancer 1 (CRCS1) ⁶⁶ Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) ⁶⁶ Termination of O-glycan biosynthesis ⁶⁶	11.75	MUC1 MUC2 MUC6
18	Listeria monocytogenes entry into host cells ⁶⁶ Show member pathways E-cadherin signaling events ¹ EGFR downregulation ⁶⁶ InlA-mediated entry of Listeria monocytogenes into host cells ⁶⁶ InlB-mediated entry of Listeria monocytogenes into host cell ⁶⁶ Negative regulation of MET activity ⁶⁶	11.65	CDH1 CTNNB1 SRC
19	Bacterial invasion of epithelial cells ³⁷	11.52	CDH1 CTNNB1 SRC
20	Bladder cancer ³⁷ ¹	11.5	CDH1 SRC TP53
21	Adherens junction ³⁷	11.44	CDH1 CTNNB1 SRC
22	G-protein signaling_Rac2 regulation pathway ²²	11.17	CDH1 CTNNB1 SRC
23	Cell adhesion_Cadherin-mediated cell adhesion ²²	11.03	CDH1 CTNNB1 SRC
24	E-cadherin signaling in keratinocytes ¹	10.88	CDH1 SRC
25	E-cadherin signaling in the nascent adherens junction ¹	10.85	CDH1 CTNNB1 SRC
26	RHO GTPases activate IQGAPs ⁶⁶	10.66	CDH1 CTNNB1
27	Nectin adhesion pathway ¹	10.2	CDH1 CTNNB1 SRC

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GO Terms for Signet Ring Cell Adenocarcinoma

Cellular components related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	apical junction complex	GO:0043296	9.16	CDH1 CTNNB1
2	Golgi lumen	GO:0005796	9.13	MUC1 MUC2 MUC6
3	flotillin complex	GO:0016600	8.62	CDH1 CTNNB1

Biological processes related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.77	CDH1 CDX2 CTNNB1 SRC TP53
2	cell-cell adhesion	GO:0098609	9.63	CDH1 CTNNB1 SRC
3	bone resorption	GO:0045453	9.51	CTNNB1 SRC
4	O-glycan processing	GO:0016266	9.5	MUC1 MUC2 MUC6
5	anterior/posterior axis specification	GO:0009948	9.49	CDX2 CTNNB1
6	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.48	MUC1 TP53
7	maintenance of gastrointestinal epithelium	GO:0030277	9.43	MUC2 MUC6
8	negative regulation of telomerase activity	GO:0051974	9.4	SRC TP53
9	adherens junction organization	GO:0034332	9.33	CDH1 CTNNB1 SRC
10	cellular response to indole-3-methanol	GO:0071681	9.26	CDH1 CTNNB1
11	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.26	MUC1 MUC2 MUC6 SRC
12	entry of bacterium into host cell	GO:0035635	8.8	CDH1 CTNNB1 SRC

Sources

Sources for Signet Ring Cell Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia