MCID: SGN002
MIFTS: 47

Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Signet Ring Cell Adenocarcinoma:

Name: Signet Ring Cell Adenocarcinoma 12 15
Carcinoma, Signet Ring Cell 44 73
Signet Ring Cell Carcinoma 12
Carcinoma Signet Ring Cell 55
Signet Ring Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3493
MeSH 44 D018279
NCIt 50 C3774
UMLS 73 C0206696

Summaries for Signet Ring Cell Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which have signet ring appearance.

MalaCards based summary : Signet Ring Cell Adenocarcinoma, also known as carcinoma, signet ring cell, is related to gastric signet ring cell adenocarcinoma and rectum adenocarcinoma. An important gene associated with Signet Ring Cell Adenocarcinoma is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are fMLP Pathway and Development HGF signaling pathway. The drugs Bevacizumab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and prostate, and related phenotypes are cardiovascular system and cellular

Related Diseases for Signet Ring Cell Adenocarcinoma

Diseases related to Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 gastric signet ring cell adenocarcinoma 34.6 CDH1 CDX2
2 rectum adenocarcinoma 30.9 CDX2 KRT20 KRT7
3 linitis plastica 30.8 CDH1 KRT20 KRT7
4 ethmoid sinusitis 30.3 MUC1 MUC2 MUC6
5 colon adenocarcinoma 30.1 CDH1 CTNNB1 KRT20
6 adenocarcinoma 29.6 CDH1 CTNNB1 MUC1 TP53
7 bladder signet ring cell adenocarcinoma 12.5
8 bile duct signet ring cell carcinoma 12.4
9 gallbladder signet ring cell adenocarcinoma 12.3
10 breast signet ring cell adenocarcinoma 12.3
11 prostate signet ring cell adenocarcinoma 12.3
12 pancreatic signet ring cell adenocarcinoma 12.2
13 ampullary signet ring cell adenocarcinoma 12.2
14 rectum signet ring adenocarcinoma 11.6
15 gastric cancer, hereditary diffuse 11.3
16 diffuse gastric cancer 11.2
17 cystic basal cell carcinoma 10.9 KRT20 KRT7
18 seminal vesicle adenocarcinoma 10.9 KRT20 KRT7
19 transverse colon cancer 10.9 KRT20 KRT7
20 eyelid neoplasm 10.9 KRT20 KRT7
21 malignant syringoma 10.8 KRT20 KRT7
22 krukenberg carcinoma 10.8 KRT20 KRT7
23 ovary neuroendocrine neoplasm 10.8 CDX2 KRT7
24 vulval paget's disease 10.8 KRT20 KRT7
25 intratubular embryonal carcinoma 10.8 KRT20 KRT7
26 mucinous adenofibroma 10.8 CDX2 KRT7
27 anus adenocarcinoma 10.8 CDX2 KRT7
28 meibomian cyst 10.7 KRT20 KRT7
29 endocervical carcinoma 10.7 KRT7 MUC6
30 adenoma of the pancreas 10.7 CHGA KRT20
31 bladder lymphoma 10.7 KRT20 KRT7
32 diversion colitis 10.7 CDH1 MUC2
33 renal pelvis adenocarcinoma 10.7 CDH1 KRT7
34 medulloepithelioma 10.7 KRT20 KRT7
35 epithelial predominant wilms' tumor 10.7 CDX2 KRT7
36 morpheaform basal cell carcinoma 10.7 CDH1 KRT20
37 renal pelvis carcinoma 10.7 KRT20 KRT7
38 chronic cholangitis 10.7 CDX2 MUC2
39 bronchiolo-alveolar adenocarcinoma 10.7 CDX2 KRT7
40 anal canal adenocarcinoma 10.6 CDX2 KRT7
41 pancreatic serous cystadenoma 10.6 CHGA KRT7
42 solid adenocarcinoma with mucin production 10.6 KRT7 MUC1
43 endosalpingiosis 10.5 KRT7 MUC1
44 appendix adenocarcinoma 10.5 CDX2 KRT20 KRT7
45 parachordoma 10.5 KRT7 MUC1
46 glandular cystitis 10.5 CDX2 KRT20 KRT7
47 middle ear adenoma 10.5 KRT7 MUC1
48 polyposis, skin pigmentation, alopecia, and fingernail changes 10.5 CDX2 MUC2
49 thymus adenocarcinoma 10.5 CDX2 KRT20 KRT7
50 jejunal adenocarcinoma 10.5 CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Signet Ring Cell Adenocarcinoma:



Diseases related to Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Signet Ring Cell Adenocarcinoma

MGI Mouse Phenotypes related to Signet Ring Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 CDH1 TUB CDX2 CHGA CTNNB1 MUC2
2 cellular MP:0005384 9.86 TUB CDH1 CDX2 CTNNB1 KRT7 MUC2
3 endocrine/exocrine gland MP:0005379 9.76 CDX2 CHGA CTNNB1 MUC2 SRC TP53
4 neoplasm MP:0002006 9.43 CDX2 CTNNB1 MUC2 SRC TP53 CDH1
5 pigmentation MP:0001186 8.92 TUB CTNNB1 SRC TP53

Drugs & Therapeutics for Signet Ring Cell Adenocarcinoma

Drugs for Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2
Fluorouracil Approved Phase 3 51-21-8 3385
3
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
4
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
5
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8 Antibodies Phase 3,Phase 2,Phase 1
9 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
10 Immunoglobulins Phase 3,Phase 2,Phase 1
11 Angiogenesis Inhibitors Phase 3
12 Angiogenesis Modulating Agents Phase 3
13 Antidotes Phase 3
14 Antimetabolites Phase 3
15 Antimetabolites, Antineoplastic Phase 3
16 Bone Density Conservation Agents Phase 3
17 Calcium, Dietary Phase 3
18 Endothelial Growth Factors Phase 3
19 Hematinics Phase 3
20 Immunoglobulin G Phase 3
21 Immunosuppressive Agents Phase 3
22 Micronutrients Phase 3
23 Mitogens Phase 3
24 Protective Agents Phase 3
25 Trace Elements Phase 3
26 Vitamin B Complex Phase 3
27 Vitamins Phase 3
28 Cola Nutraceutical Phase 3,Phase 1,Phase 2
29 Folate Nutraceutical Phase 3
30 Vitamin B9 Nutraceutical Phase 3
31
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
32
nivolumab Approved Phase 2 946414-94-4
33 Alkylating Agents Phase 1, Phase 2
34 Anti-Bacterial Agents Phase 1, Phase 2
35 Antibiotics, Antitubercular Phase 1, Phase 2
36 Mitomycins Phase 1, Phase 2
37 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
38
Cetuximab Approved Phase 1 205923-56-4 56842117 2333

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
2 XELOX Plus Apatinib vs XELOX as Post-operative Chemotherapy in Locally Advanced Gastric Signet Ring Carcinoma Not yet recruiting NCT03355612 Phase 3 Apatinib;XELOX
3 Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients Completed NCT02575859 Phase 1, Phase 2 adjuvant HIPEC
4 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
5 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
6 QUILT-3.017: Study of NEO-201 in Solid Tumors Not yet recruiting NCT03476681 Phase 1 NEO-201
7 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
8 Prognosis of Signet Ring Cells in Upper Digestive Neoplasms Completed NCT01249859
9 Signet Ring Cell Carcinoma in Esophageal Adenocarcinoma Completed NCT01824966
10 NBI for Identifying Resection Margin Status in Gastric Cancer Completed NCT02926716
11 Socioeconomic Position in Acute Colorectal Cancer Surgery Active, not recruiting NCT03581890

Search NIH Clinical Center for Signet Ring Cell Adenocarcinoma

Cochrane evidence based reviews: carcinoma, signet ring cell

Genetic Tests for Signet Ring Cell Adenocarcinoma

Anatomical Context for Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Cell Adenocarcinoma:

41
Colon, Bone, Prostate, Skin, Endothelial, Cervix, Lung

Publications for Signet Ring Cell Adenocarcinoma

Articles related to Signet Ring Cell Adenocarcinoma:

(show top 50) (show all 78)
# Title Authors Year
1
Diffuse-type Gastric Mucinous and Signet Ring Cell Adenocarcinoma in a Captive California King Snake (Lampropeltis getula californiae). ( 29729716 )
2018
2
Dystrophic Adipocytes Mimicking Metastatic Signet Ring Cell Adenocarcinoma: A Diagnostic Pitfall in a Cachectic Patient. ( 29854530 )
2018
3
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. ( 29801472 )
2018
4
Treatment of a pediatric patient with MET-amplified signet ring cell adenocarcinoma of the stomach with crizotinib. ( 29380521 )
2018
5
Leptomeningeal carcinomatosis in a young patient with obstructive colorectal signet- ring cell adenocarcinoma. ( 28530107 )
2017
6
Peritoneal carcinomatosis from signet-ring cell adenocarcinoma of the appendix. ( 28322773 )
2017
7
Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. ( 28326211 )
2017
8
The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus. ( 29212656 )
2017
9
Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature. ( 29375924 )
2017
10
Pulmonary Signet-Ring Cell Adenocarcinoma Metastatic to the Skin. ( 27898475 )
2016
11
A Rare Case of an Adult with Untreated Bladder Exstrophy Presenting with Signet-Ring Cell Adenocarcinoma of Urinary Bladder. ( 28050437 )
2016
12
Primary signet ring cell adenocarcinoma of the uterine cervix - A rare neoplasm that raises the question of metastasis to the cervix. ( 27331127 )
2016
13
A rare case of metastatic germ cell tumor to stomach and duodenum masquerading as signet ring cell adenocarcinoma. ( 27668229 )
2016
14
Primary signet-ring cell adenocarcinoma of the head and neck: a case study and brief review. ( 27185232 )
2016
15
Signet Ring Cell Adenocarcinoma and Bilateral Leptomeningeal Involvement of Optic Nerve Sheaths. ( 25839780 )
2015
16
Colonic-type appendiceal adenocarcinoma: an intermediate prognosis between mucinous and signet ring cell adenocarcinoma. ( 26735622 )
2015
17
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
18
A case with primary signet ring cell adenocarcinoma of the prostate and review of the literature. ( 25017602 )
2014
19
Primary Signet Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of 2 Cases. ( 26955554 )
2014
20
The impact of preoperative radiochemotherapy on survival in advanced esophagogastric junction signet ring cell adenocarcinoma. ( 24200394 )
2014
21
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
22
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
23
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
24
Primary signet-ring cell adenocarcinoma of the uterine cervix: case report and review of the literature. ( 24020147 )
2013
25
Metastatic signet ring cell adenocarcinoma of the bladder: responsive to treatment? ( 22396377 )
2012
26
Primary pure signet-ring cell adenocarcinoma of the urinary bladder: a report of three cases with an immunohistochemical study. ( 22120516 )
2012
27
Signet ring cell adenocarcinoma of the ampulla of Vater: a rare patho. ( 23130863 )
2012
28
Interval signet-ring cell adenocarcinoma of the colon: missed or de novo? ( 21540911 )
2011
29
A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation. ( 22022068 )
2011
30
Secondary signet-ring cell adenocarcinoma of urinary bladder from a gastric primary. ( 21747602 )
2011
31
Primary pure signet ring cell adenocarcinoma of non-Barrett's esophagus. ( 22275019 )
2011
32
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
33
An unusual case of signet ring cell adenocarcinoma of the prostate. ( 21797141 )
2011
34
Morphometric distinction of signet-ring cell adenocarcinoma cells from foamy macrophages in gastric endoscopic biopsies. ( 22102070 )
2011
35
Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report. ( 21719143 )
2011
36
Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon. ( 20737376 )
2010
37
Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. ( 20378938 )
2010
38
Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature. ( 20407328 )
2010
39
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
40
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
41
Signet-ring-cell adenocarcinoma of the myocardium presenting as persistent pleural effusions. ( 19772035 )
2009
42
Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. ( 18789486 )
2009
43
Signet ring cell adenocarcinoma of the oropharynx: presentation of a rare case and review of the literature. ( 19446973 )
2009
44
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
45
Metastatic signet ring cell adenocarcinoma of bone marrow with bilateral ovarian masses: a case report. ( 19019234 )
2008
46
Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report. ( 17913950 )
2007
47
Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile. ( 17550327 )
2007
48
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
49
FDG PET imaging of signet-ring cell adenocarcinoma of the stomach. ( 15647683 )
2005
50
Primary signet ring cell adenocarcinoma of the bladder. ( 15951737 )
2005

Variations for Signet Ring Cell Adenocarcinoma

Expression for Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Cell Adenocarcinoma.

Pathways for Signet Ring Cell Adenocarcinoma

Pathways related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 CDH1 CDX2 CTNNB1 SRC TP53
2
Show member pathways
12.53 CDH1 CTNNB1 SRC TP53
3
Show member pathways
12.43 CDH1 CDX2 CTNNB1 MUC2 TP53
4 12.28 CDH1 KRT20 KRT7 MUC1
5
Show member pathways
12.15 MUC1 MUC2 MUC6 SRC
6
Show member pathways
12.1 CDH1 CTNNB1 SRC
7
Show member pathways
12.07 MUC1 MUC2 MUC6
8 11.99 CDH1 CTNNB1 TP53
9
Show member pathways
11.96 MUC1 MUC2 MUC6
10 11.91 CTNNB1 SRC TP53
11 11.85 CDH1 CTNNB1 MUC1
12 11.84 CDH1 CTNNB1 SRC
13 11.84 CDH1 CTNNB1 SRC TP53
14
Show member pathways
11.84 CDH1 CTNNB1 MUC1 SRC TP53
15 11.81 CTNNB1 SRC TP53
16 11.78 CTNNB1 SRC TP53
17
Show member pathways
11.75 MUC1 MUC2 MUC6
18
Show member pathways
11.65 CDH1 CTNNB1 SRC
19 11.52 CDH1 CTNNB1 SRC
20 11.5 CDH1 SRC TP53
21 11.44 CDH1 CTNNB1 SRC
22 11.17 CDH1 CTNNB1 SRC
23 11.03 CDH1 CTNNB1 SRC
24 10.88 CDH1 SRC
25 10.85 CDH1 CTNNB1 SRC
26 10.66 CDH1 CTNNB1
27 10.2 CDH1 CTNNB1 SRC

GO Terms for Signet Ring Cell Adenocarcinoma

Cellular components related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 9.16 CDH1 CTNNB1
2 Golgi lumen GO:0005796 9.13 MUC1 MUC2 MUC6
3 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 CDH1 CDX2 CTNNB1 SRC TP53
2 cell-cell adhesion GO:0098609 9.63 CDH1 CTNNB1 SRC
3 bone resorption GO:0045453 9.51 CTNNB1 SRC
4 O-glycan processing GO:0016266 9.5 MUC1 MUC2 MUC6
5 anterior/posterior axis specification GO:0009948 9.49 CDX2 CTNNB1
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.48 MUC1 TP53
7 maintenance of gastrointestinal epithelium GO:0030277 9.43 MUC2 MUC6
8 negative regulation of telomerase activity GO:0051974 9.4 SRC TP53
9 adherens junction organization GO:0034332 9.33 CDH1 CTNNB1 SRC
10 cellular response to indole-3-methanol GO:0071681 9.26 CDH1 CTNNB1
11 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC1 MUC2 MUC6 SRC
12 entry of bacterium into host cell GO:0035635 8.8 CDH1 CTNNB1 SRC

Sources for Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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