Signet Ring Lung Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Signet Ring Lung Adenocarcinoma

MalaCards integrated aliases for Signet Ring Lung Adenocarcinoma:

Name: Signet Ring Lung Adenocarcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080305

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Summaries for Signet Ring Lung Adenocarcinoma

Disease Ontology : ¹² A lung adenocarcinoma containing a signet cell ring component characterized by abundant intracellular mucin accumulation and a displaced crescentic nucleus.

MalaCards based summary : Signet Ring Lung Adenocarcinoma is related to adenocarcinoma and lung cancer susceptibility 3. An important gene associated with Signet Ring Lung Adenocarcinoma is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, and related phenotype is Decreased substrate adherent cell growth.

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Related Diseases for Signet Ring Lung Adenocarcinoma

Diseases related to Signet Ring Lung Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	29.6	EGFR ALK
2	lung cancer susceptibility 3	29.2	EGFR ALK
3	lung papillary adenocarcinoma	9.9	EML4 ALK
4	lung adenoid cystic carcinoma	9.9	EML4 ALK
5	childhood kidney cell carcinoma	9.9	EML4 ALK
6	inflammatory myofibroblastic tumor	9.8	EML4 ALK
7	pleomorphic carcinoma	9.6	EGFR ALK
8	mucinous lung adenocarcinoma	9.6	EGFR ALK
9	adenosquamous lung carcinoma	9.5	EGFR ALK
10	mucinous adenocarcinoma	9.5	EGFR ALK
11	differentiated thyroid carcinoma	9.4	EGFR ALK
12	lung squamous cell carcinoma	9.4	EGFR ALK
13	in situ pulmonary adenocarcinoma	9.2	EML4 EGFR ALK
14	respiratory system cancer	9.2	EML4 EGFR ALK
15	respiratory system disease	9.1	EML4 EGFR ALK
16	brain cancer	9.1	EGFR ALK
17	lung cancer	8.8	EML4 EGFR ALK

Graphical network of the top 20 diseases related to Signet Ring Lung Adenocarcinoma:

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Symptoms & Phenotypes for Signet Ring Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-2	8.62	ALK EGFR

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Drugs & Therapeutics for Signet Ring Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Signet Ring Lung Adenocarcinoma

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Genetic Tests for Signet Ring Lung Adenocarcinoma

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Anatomical Context for Signet Ring Lung Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Lung Adenocarcinoma:

⁴¹

Lung

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Publications for Signet Ring Lung Adenocarcinoma

Articles related to Signet Ring Lung Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Complete radiological response of metastatic anaplastic lymphoma kinase-positive signet ring lung adenocarcinoma to systemic chemotherapy. ³⁸	Korpanty G...Carney DN	21623269	2011

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Genes for Signet Ring Lung Adenocarcinoma

Genes related to Signet Ring Lung Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	14.33	DISEASES inferred ¹⁵
2	EGFR	Epidermal Growth Factor Receptor	Protein Coding	13.54	DISEASES inferred ¹⁵
3	EML4	EMAP Like 4	Protein Coding	5.29	DISEASES inferred ¹⁵

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Variations for Signet Ring Lung Adenocarcinoma

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Expression for Signet Ring Lung Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Lung Adenocarcinoma.

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Pathways for Signet Ring Lung Adenocarcinoma

Pathways related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	11.86	EML4 EGFR ALK
2	Glioma ³⁷ Show member pathways Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	11.39	EML4 EGFR ALK
3	Tyrosine Kinases / Adaptors ⁴	11.33	EGFR ALK

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GO Terms for Signet Ring Lung Adenocarcinoma

Cellular components related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	8.62	EGFR ALK

Biological processes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-tyrosine phosphorylation	GO:0018108	9.26	EGFR ALK
2	regulation of cell proliferation	GO:0042127	9.16	EGFR ALK
3	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.07	EGFR
4	positive regulation of protein phosphorylation	GO:0001934	9.02	EGFR
5	protein autophosphorylation	GO:0046777	8.96	EGFR ALK
6	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	8.62	EGFR ALK

Molecular functions related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	8.96	EGFR ALK
2	transmembrane signaling receptor activity	GO:0004888	8.85	EGFR
3	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.62	EGFR ALK

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Sources for Signet Ring Lung Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia