MCID: SGN005
MIFTS: 19

Signet Ring Lung Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Signet Ring Lung Adenocarcinoma

MalaCards integrated aliases for Signet Ring Lung Adenocarcinoma:

Name: Signet Ring Lung Adenocarcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080305

Summaries for Signet Ring Lung Adenocarcinoma

Disease Ontology : 12 A lung adenocarcinoma containing a signet cell ring component characterized by abundant intracellular mucin accumulation and a displaced crescentic nucleus.

MalaCards based summary : Signet Ring Lung Adenocarcinoma is related to lung cancer susceptibility 3 and adenocarcinoma. An important gene associated with Signet Ring Lung Adenocarcinoma is EML4 (EMAP Like 4), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, thyroid and occipital lobe, and related phenotype is Decreased substrate adherent cell growth.

Related Diseases for Signet Ring Lung Adenocarcinoma

Graphical network of the top 20 diseases related to Signet Ring Lung Adenocarcinoma:



Diseases related to Signet Ring Lung Adenocarcinoma

Symptoms & Phenotypes for Signet Ring Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-2 8.62 ALK EGFR

Drugs & Therapeutics for Signet Ring Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Signet Ring Lung Adenocarcinoma

Genetic Tests for Signet Ring Lung Adenocarcinoma

Anatomical Context for Signet Ring Lung Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Lung Adenocarcinoma:

40
Lung, Thyroid, Occipital Lobe

Publications for Signet Ring Lung Adenocarcinoma

Articles related to Signet Ring Lung Adenocarcinoma:

# Title Authors PMID Year
1
Complete radiological response of metastatic anaplastic lymphoma kinase-positive signet ring lung adenocarcinoma to systemic chemotherapy. 61
21623269 2011

Variations for Signet Ring Lung Adenocarcinoma

Expression for Signet Ring Lung Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Lung Adenocarcinoma.

Pathways for Signet Ring Lung Adenocarcinoma

GO Terms for Signet Ring Lung Adenocarcinoma

Cellular components related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.62 EGFR ALK

Biological processes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.32 EGFR ALK
2 regulation of cell proliferation GO:0042127 9.26 EGFR ALK
3 protein autophosphorylation GO:0046777 9.16 EGFR ALK
4 peptidyl-tyrosine phosphorylation GO:0018108 8.96 EGFR ALK
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.62 EGFR ALK

Molecular functions related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.96 EGFR ALK
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 EGFR ALK

Sources for Signet Ring Lung Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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