MCID: SGN005
MIFTS: 18

Signet Ring Lung Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Signet Ring Lung Adenocarcinoma

MalaCards integrated aliases for Signet Ring Lung Adenocarcinoma:

Name: Signet Ring Lung Adenocarcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080305

Summaries for Signet Ring Lung Adenocarcinoma

Disease Ontology : 12 A lung adenocarcinoma containing a signet cell ring component characterized by abundant intracellular mucin accumulation and a displaced crescentic nucleus.

MalaCards based summary : Signet Ring Lung Adenocarcinoma is related to lung cancer susceptibility 3 and adenocarcinoma. An important gene associated with Signet Ring Lung Adenocarcinoma is EML4 (EMAP Like 4), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, and related phenotype is Decreased substrate adherent cell growth.

Related Diseases for Signet Ring Lung Adenocarcinoma

Diseases related to Signet Ring Lung Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 lung cancer susceptibility 3 10.1
2 adenocarcinoma 10.1
3 small cell carcinoma 9.8 EGFR ALK
4 adenosquamous lung carcinoma 9.8 EGFR ALK
5 paronychia 9.8 EGFR ALK
6 pleomorphic carcinoma 9.8 EGFR ALK
7 large cell neuroendocrine carcinoma 9.8 EGFR ALK
8 peritoneal mesothelioma 9.8 EGFR ALK
9 mucinous adenocarcinoma 9.8 EGFR ALK
10 differentiated thyroid carcinoma 9.8 EGFR ALK
11 small cell cancer of the lung 9.8 EGFR ALK
12 occipital lobe neoplasm 9.8 EML4 ALK
13 thyroid gland follicular carcinoma 9.8 EGFR ALK
14 lung sarcomatoid carcinoma 9.8 EML4 ALK
15 pediatric fibrosarcoma 9.8 EML4 ALK
16 retinitis pigmentosa 11 9.8 EGFR ALK
17 mesenchymal cell neoplasm 9.8 EML4 ALK
18 thyroid gland anaplastic carcinoma 9.8 EGFR ALK
19 autonomic nervous system neoplasm 9.8 EGFR ALK
20 peripheral nervous system neoplasm 9.7 EGFR ALK
21 lung disease 9.7 EML4 EGFR
22 inflammatory myofibroblastic tumor 9.7 EML4 ALK
23 lung squamous cell carcinoma 9.7 EGFR ALK
24 thyroid gland cancer 9.7 EGFR ALK
25 skin melanoma 9.7 EGFR ALK
26 brain cancer 9.7 EGFR ALK
27 respiratory system disease 9.6 EGFR ALK
28 lung carcinoma in situ 9.5 EML4 EGFR ALK
29 pulmonary adenocarcinoma in situ 9.5 EML4 EGFR ALK
30 lung non-squamous non-small cell carcinoma 9.5 EML4 EGFR ALK
31 peripheral nervous system disease 9.5 EGFR ALK
32 lymphoma 9.5 EML4 EGFR ALK

Graphical network of the top 20 diseases related to Signet Ring Lung Adenocarcinoma:



Diseases related to Signet Ring Lung Adenocarcinoma

Symptoms & Phenotypes for Signet Ring Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-2 8.62 ALK EGFR

Drugs & Therapeutics for Signet Ring Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Signet Ring Lung Adenocarcinoma

Genetic Tests for Signet Ring Lung Adenocarcinoma

Anatomical Context for Signet Ring Lung Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Lung Adenocarcinoma:

40
Lung

Publications for Signet Ring Lung Adenocarcinoma

Articles related to Signet Ring Lung Adenocarcinoma:

# Title Authors PMID Year
1
Complete radiological response of metastatic anaplastic lymphoma kinase-positive signet ring lung adenocarcinoma to systemic chemotherapy. 61
21623269 2011

Variations for Signet Ring Lung Adenocarcinoma

Expression for Signet Ring Lung Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Lung Adenocarcinoma.

Pathways for Signet Ring Lung Adenocarcinoma

GO Terms for Signet Ring Lung Adenocarcinoma

Cellular components related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.62 EGFR ALK

Biological processes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.26 EGFR ALK
2 peptidyl-tyrosine phosphorylation GO:0018108 9.16 EGFR ALK
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.96 EGFR ALK
4 positive regulation of kinase activity GO:0033674 8.62 EGFR ALK

Molecular functions related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.96 EGFR ALK
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 EGFR ALK

Sources for Signet Ring Lung Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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