MCID: SGN005
MIFTS: 17

Signet Ring Lung Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Signet Ring Lung Adenocarcinoma

MalaCards integrated aliases for Signet Ring Lung Adenocarcinoma:

Name: Signet Ring Lung Adenocarcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080305

Summaries for Signet Ring Lung Adenocarcinoma

Disease Ontology : 12 A lung adenocarcinoma containing a signet cell ring component characterized by abundant intracellular mucin accumulation and a displaced crescentic nucleus.

MalaCards based summary : Signet Ring Lung Adenocarcinoma is related to adenocarcinoma and lung cancer susceptibility 3. An important gene associated with Signet Ring Lung Adenocarcinoma is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, and related phenotype is Decreased substrate adherent cell growth.

Related Diseases for Signet Ring Lung Adenocarcinoma

Graphical network of the top 20 diseases related to Signet Ring Lung Adenocarcinoma:



Diseases related to Signet Ring Lung Adenocarcinoma

Symptoms & Phenotypes for Signet Ring Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-2 8.62 ALK EGFR

Drugs & Therapeutics for Signet Ring Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Signet Ring Lung Adenocarcinoma

Genetic Tests for Signet Ring Lung Adenocarcinoma

Anatomical Context for Signet Ring Lung Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Lung Adenocarcinoma:

41
Lung

Publications for Signet Ring Lung Adenocarcinoma

Articles related to Signet Ring Lung Adenocarcinoma:

# Title Authors PMID Year
1
Complete radiological response of metastatic anaplastic lymphoma kinase-positive signet ring lung adenocarcinoma to systemic chemotherapy. 38
21623269 2011

Variations for Signet Ring Lung Adenocarcinoma

Expression for Signet Ring Lung Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Lung Adenocarcinoma.

Pathways for Signet Ring Lung Adenocarcinoma

Pathways related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.86 EML4 EGFR ALK
2
Show member pathways
11.39 EML4 EGFR ALK
3 11.33 EGFR ALK

GO Terms for Signet Ring Lung Adenocarcinoma

Cellular components related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.62 EGFR ALK

Biological processes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.26 EGFR ALK
2 regulation of cell proliferation GO:0042127 9.16 EGFR ALK
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.07 EGFR
4 positive regulation of protein phosphorylation GO:0001934 9.02 EGFR
5 protein autophosphorylation GO:0046777 8.96 EGFR ALK
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.62 EGFR ALK

Molecular functions related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.96 EGFR ALK
2 transmembrane signaling receptor activity GO:0004888 8.85 EGFR
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 EGFR ALK

Sources for Signet Ring Lung Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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