Signet Ring Lung Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Signet Ring Lung Adenocarcinoma

MalaCards integrated aliases for Signet Ring Lung Adenocarcinoma:

Name: Signet Ring Lung Adenocarcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080305

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Summaries for Signet Ring Lung Adenocarcinoma

Disease Ontology : ¹² A lung adenocarcinoma containing a signet cell ring component characterized by abundant intracellular mucin accumulation and a displaced crescentic nucleus.

MalaCards based summary : Signet Ring Lung Adenocarcinoma is related to lung cancer susceptibility 3 and adenocarcinoma. An important gene associated with Signet Ring Lung Adenocarcinoma is EML4 (EMAP Like 4), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, and related phenotype is Decreased substrate adherent cell growth.

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Related Diseases for Signet Ring Lung Adenocarcinoma

Diseases related to Signet Ring Lung Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	lung cancer susceptibility 3	10.1
2	adenocarcinoma	10.1
3	small cell carcinoma	9.8	EGFR ALK
4	adenosquamous lung carcinoma	9.8	EGFR ALK
5	paronychia	9.8	EGFR ALK
6	pleomorphic carcinoma	9.8	EGFR ALK
7	large cell neuroendocrine carcinoma	9.8	EGFR ALK
8	peritoneal mesothelioma	9.8	EGFR ALK
9	mucinous adenocarcinoma	9.8	EGFR ALK
10	differentiated thyroid carcinoma	9.8	EGFR ALK
11	small cell cancer of the lung	9.8	EGFR ALK
12	occipital lobe neoplasm	9.8	EML4 ALK
13	thyroid gland follicular carcinoma	9.8	EGFR ALK
14	lung sarcomatoid carcinoma	9.8	EML4 ALK
15	pediatric fibrosarcoma	9.8	EML4 ALK
16	retinitis pigmentosa 11	9.8	EGFR ALK
17	mesenchymal cell neoplasm	9.8	EML4 ALK
18	thyroid gland anaplastic carcinoma	9.8	EGFR ALK
19	autonomic nervous system neoplasm	9.8	EGFR ALK
20	peripheral nervous system neoplasm	9.7	EGFR ALK
21	lung disease	9.7	EML4 EGFR
22	inflammatory myofibroblastic tumor	9.7	EML4 ALK
23	lung squamous cell carcinoma	9.7	EGFR ALK
24	thyroid gland cancer	9.7	EGFR ALK
25	skin melanoma	9.7	EGFR ALK
26	brain cancer	9.7	EGFR ALK
27	respiratory system disease	9.6	EGFR ALK
28	lung carcinoma in situ	9.5	EML4 EGFR ALK
29	pulmonary adenocarcinoma in situ	9.5	EML4 EGFR ALK
30	lung non-squamous non-small cell carcinoma	9.5	EML4 EGFR ALK
31	peripheral nervous system disease	9.5	EGFR ALK
32	lymphoma	9.5	EML4 EGFR ALK

Graphical network of the top 20 diseases related to Signet Ring Lung Adenocarcinoma:

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Symptoms & Phenotypes for Signet Ring Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-2	8.62	ALK EGFR

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Drugs & Therapeutics for Signet Ring Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Signet Ring Lung Adenocarcinoma

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Genetic Tests for Signet Ring Lung Adenocarcinoma

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Anatomical Context for Signet Ring Lung Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Lung Adenocarcinoma:

⁴⁰

Lung

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Publications for Signet Ring Lung Adenocarcinoma

Articles related to Signet Ring Lung Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Complete radiological response of metastatic anaplastic lymphoma kinase-positive signet ring lung adenocarcinoma to systemic chemotherapy. ⁶¹	Korpanty G...Carney DN	21623269	2011

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Genes for Signet Ring Lung Adenocarcinoma

Genes related to Signet Ring Lung Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	EML4	EMAP Like 4	Protein Coding	5.78	DISEASES inferred ¹⁵
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	5.01	DISEASES inferred ¹⁵
3	EGFR	Epidermal Growth Factor Receptor	Protein Coding	4.29	DISEASES inferred ¹⁵

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Variations for Signet Ring Lung Adenocarcinoma

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Expression for Signet Ring Lung Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Lung Adenocarcinoma.

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Pathways for Signet Ring Lung Adenocarcinoma

Pathways related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.16	EML4 EGFR ALK
2	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	11.73	EML4 EGFR ALK
3	Tyrosine Kinases / Adaptors ⁴	11.49	EGFR ALK
4	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	11.34	EML4 EGFR ALK
5	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.74	EML4 ALK

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GO Terms for Signet Ring Lung Adenocarcinoma

Cellular components related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	8.62	EGFR ALK

Biological processes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein autophosphorylation	GO:0046777	9.26	EGFR ALK
2	peptidyl-tyrosine phosphorylation	GO:0018108	9.16	EGFR ALK
3	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	8.96	EGFR ALK
4	positive regulation of kinase activity	GO:0033674	8.62	EGFR ALK

Molecular functions related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	8.96	EGFR ALK
2	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.62	EGFR ALK

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Sources for Signet Ring Lung Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia