Signet Ring Lung Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Signet Ring Lung Adenocarcinoma

MalaCards integrated aliases for Signet Ring Lung Adenocarcinoma:

Name: Signet Ring Lung Adenocarcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080305

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Summaries for Signet Ring Lung Adenocarcinoma

Disease Ontology : ¹² A lung adenocarcinoma containing a signet cell ring component characterized by abundant intracellular mucin accumulation and a displaced crescentic nucleus.

MalaCards based summary : Signet Ring Lung Adenocarcinoma is related to lung cancer susceptibility 3 and adenocarcinoma. An important gene associated with Signet Ring Lung Adenocarcinoma is EML4 (EMAP Like 4), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, thyroid and occipital lobe, and related phenotype is Decreased substrate adherent cell growth.

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Related Diseases for Signet Ring Lung Adenocarcinoma

Diseases related to Signet Ring Lung Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	lung cancer susceptibility 3	28.9	EML4 EGFR ALK
2	adenocarcinoma	10.1
3	adenosquamous lung carcinoma	9.7	EGFR ALK
4	lung acinar adenocarcinoma	9.7	EGFR ALK
5	in situ pulmonary adenocarcinoma	9.7	EGFR ALK
6	pleomorphic carcinoma	9.7	EGFR ALK
7	adenocarcinoma in situ	9.7	EGFR ALK
8	large cell neuroendocrine carcinoma	9.7	EGFR ALK
9	mucinous adenocarcinoma	9.7	EGFR ALK
10	differentiated thyroid carcinoma	9.7	EGFR ALK
11	occipital lobe neoplasm	9.7	EML4 ALK
12	mesenchymal cell neoplasm	9.6	EML4 ALK
13	small cell carcinoma	9.6	EGFR ALK
14	autonomic nervous system neoplasm	9.6	EGFR ALK
15	lung disease	9.5	EML4 EGFR
16	inflammatory myofibroblastic tumor	9.5	EML4 ALK
17	peripheral nervous system neoplasm	9.5	EGFR ALK
18	renal cell carcinoma, papillary, 1	9.5	EGFR ALK
19	rhabdomyosarcoma	9.2	EGFR ALK
20	lymphoma	9.2	EML4 EGFR ALK
21	neuroblastoma	9.1	EML4 EGFR ALK

Graphical network of the top 20 diseases related to Signet Ring Lung Adenocarcinoma:

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Symptoms & Phenotypes for Signet Ring Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-2	8.62	ALK EGFR

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Drugs & Therapeutics for Signet Ring Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Signet Ring Lung Adenocarcinoma

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Genetic Tests for Signet Ring Lung Adenocarcinoma

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Anatomical Context for Signet Ring Lung Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Lung Adenocarcinoma:

⁴⁰

Lung, Thyroid, Occipital Lobe

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Publications for Signet Ring Lung Adenocarcinoma

Articles related to Signet Ring Lung Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Complete radiological response of metastatic anaplastic lymphoma kinase-positive signet ring lung adenocarcinoma to systemic chemotherapy. ⁶¹	Korpanty G...Carney DN	21623269	2011

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Genes for Signet Ring Lung Adenocarcinoma

Genes related to Signet Ring Lung Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	EML4	EMAP Like 4	Protein Coding	5.88	DISEASES inferred ¹⁵
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	5.12	DISEASES inferred ¹⁵
3	EGFR	Epidermal Growth Factor Receptor	Protein Coding	4.38	DISEASES inferred ¹⁵

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Variations for Signet Ring Lung Adenocarcinoma

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Expression for Signet Ring Lung Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Lung Adenocarcinoma.

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Pathways for Signet Ring Lung Adenocarcinoma

Pathways related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.16	EML4 EGFR ALK
2	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	11.73	EML4 EGFR ALK
3	Tyrosine Kinases / Adaptors ⁴	11.49	EGFR ALK
4	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	11.34	EML4 EGFR ALK
5	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.74	EML4 ALK

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GO Terms for Signet Ring Lung Adenocarcinoma

Cellular components related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	8.62	EGFR ALK

Biological processes related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell proliferation	GO:0008283	9.32	EGFR ALK
2	regulation of cell proliferation	GO:0042127	9.26	EGFR ALK
3	protein autophosphorylation	GO:0046777	9.16	EGFR ALK
4	peptidyl-tyrosine phosphorylation	GO:0018108	8.96	EGFR ALK
5	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	8.62	EGFR ALK

Molecular functions related to Signet Ring Lung Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	8.96	EGFR ALK
2	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.62	EGFR ALK

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Sources for Signet Ring Lung Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia