MCID: SLN001
MIFTS: 24

Silent Myocardial Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Silent Myocardial Infarction

MalaCards integrated aliases for Silent Myocardial Infarction:

Name: Silent Myocardial Infarction 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5854
NCIt 50 C35400
UMLS 73 C0340324

Summaries for Silent Myocardial Infarction

MalaCards based summary : Silent Myocardial Infarction is related to myocardial infarction and diabetes mellitus. An important gene associated with Silent Myocardial Infarction is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Glyburide and Glimepiride have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney.

Related Diseases for Silent Myocardial Infarction

Graphical network of the top 20 diseases related to Silent Myocardial Infarction:



Diseases related to Silent Myocardial Infarction

Symptoms & Phenotypes for Silent Myocardial Infarction

Drugs & Therapeutics for Silent Myocardial Infarction

Drugs for Silent Myocardial Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4 10238-21-8 3488
2
Glimepiride Approved Phase 4,Phase 3 93479-97-1 3476
3
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
4
Gliclazide Approved Phase 4 21187-98-4 3475
5
Metformin Approved Phase 4 657-24-9 14219 4091
6
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
7
Chromium Approved Phase 4 7440-47-3 27668
8
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
9
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
10 Hypoglycemic Agents Phase 4,Phase 3
11 Micronutrients Phase 4
12 Trace Elements Phase 4
13 Anesthetics, General Phase 4
14 Anesthetics Phase 4
15 Analgesics Phase 4
16 Anesthetics, Inhalation Phase 4
17 Central Nervous System Depressants Phase 4
18 Analgesics, Non-Narcotic Phase 4
19 Peripheral Nervous System Agents Phase 4
20
Empagliflozin Approved Phase 3 864070-44-0
21
Lovastatin Approved, Investigational Phase 3 75330-75-5 53232
22
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
23
Fluvastatin Approved Phase 3 93957-54-1 1548972
24
Ezetimibe Approved Phase 3 163222-33-1 150311
25
Simvastatin Approved Phase 3 79902-63-9 54454
26
Pravastatin Approved Phase 3 81093-37-0 54687
27
Fenofibrate Approved Phase 3 49562-28-9 3339
28
Linagliptin Approved Phase 3 668270-12-0 10096344
29 Nutmeg Approved Phase 3
30
Warfarin Approved Phase 3 81-81-2 6691 54678486
31
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
32
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
33
Darapladib Investigational Phase 3 356057-34-6 9939609
34 Eicosapentaenoic acid ethyl ester Phase 3
35 Vitamin B3 Phase 3
36 L 647318 Phase 3
37 Atorvastatin Calcium Phase 3 134523-03-8
38 Ezetimibe, Simvastatin Drug Combination Phase 3
39 Anticholesteremic Agents Phase 3
40 Lipid Regulating Agents Phase 3
41 Dihydromevinolin Phase 3
42 Rosuvastatin Calcium Phase 3 147098-20-2
43 Hypolipidemic Agents Phase 3
44 Platelet Aggregation Inhibitors Phase 3
45 Clofibric Acid Phase 3 882-09-7
46 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
47 Omega 3 Fatty Acid Phase 3
48 Nicotinic Acids Phase 3
49
protease inhibitors Phase 3
50 Immunosuppressive Agents Phase 3

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial Unknown status NCT00700856 Phase 4 add-on pioglitazone;add-on sulphonylurea
2 Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII Unknown status NCT01918150 Phase 4
3 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial Completed NCT00430989 Phase 4 Nitrous Oxide;Nitrous Oxide
4 BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). Completed NCT01131676 Phase 3 BI 10773 low dose;Placebo BI 10773 high dose;BI 10773 high dose;Placebo BI 10773 low dose;Placebo BI 10773 low dose;Placebo BI 10773 high dose
5 A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event. Completed NCT01492361 Phase 3 AMR101;Placebo
6 CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Completed NCT01243424 Phase 3 linagliptin;glimepiride;linagliptin placebo;glimepride placebo
7 The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial Completed NCT01000727 Phase 3 Darapladib 160 mg;Placebo
8 The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial Completed NCT00799903 Phase 3 Darapladib;Placebo
9 Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate Completed NCT00262600 Phase 3 warfarin;Dabigatran dose 1;Dabigatran dose 2
10 RELY-ABLE Long Term Multi-center Extension of Dabigatran Treatment in Patients With Atrial Fibrillation Who Completed RE-LY Trial Completed NCT00808067 Phase 3 dabigatran dose 1;dabigatran dose 2
11 MYOCARDIAL SILENT INFARCTIONS AND FIBROSIS IN FAMILIAL HYPERCHOLESTEROLEMIA (CHOLCOEUR) Unknown status NCT02517944
12 Pain Perception is Attenuated in Patients With Painless Myocardial Infarction Completed NCT00192790
13 Microparticles in Obstructive Sleep Apnea Recruiting NCT03438149

Search NIH Clinical Center for Silent Myocardial Infarction

Genetic Tests for Silent Myocardial Infarction

Anatomical Context for Silent Myocardial Infarction

MalaCards organs/tissues related to Silent Myocardial Infarction:

41
Heart, Lung, Kidney

Publications for Silent Myocardial Infarction

Articles related to Silent Myocardial Infarction:

(show top 50) (show all 78)
# Title Authors Year
1
Silent Myocardial Infarction: Listen to the Evidence. ( 29301632 )
2018
2
Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report. ( 29471871 )
2018
3
A Combination of Tachycardia-Mediated Heart Failure and Coronary Artery Vasospasm-Induced Silent Myocardial Infarction in a Patient with Severe Thyrotoxicosis. ( 29713551 )
2018
4
Silent Myocardial Infarction and Long-Term Risk of Heart Failure: The ARIC Study. ( 29301615 )
2018
5
Acute coronary syndromes: Silent myocardial infarction increases the risk of heart failure. ( 29368702 )
2018
6
Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction. ( 29680352 )
2018
7
A silent myocardial infarction with normal coronary arteries associated with Graves' disease. ( 30503299 )
2018
8
Silent myocardial infarction and risk of heart failure: Current evidence and gaps in knowledge. ( 30224236 )
2018
9
Unruptured giant left ventricular pseudoaneurysm after silent myocardial infarction. ( 30021745 )
2018
10
Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. ( 28515002 )
2017
11
Woven coronary anomaly leading to silent myocardial infarction: A case report. ( 29095260 )
2017
12
Prognostic value of silent myocardial infarction in patients with chronic kidney disease being evaluated for kidney transplantation. ( 28958755 )
2017
13
Race and Sex Differences in the Incidence and Prognostic Significance of Silent Myocardial Infarction in the Atherosclerosis Risk in Communities (ARIC) Study. ( 27185168 )
2016
14
A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes. ( 27300573 )
2016
15
Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report. ( 26925778 )
2016
16
Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. ( 27209284 )
2016
17
Silent myocardial infarction secondary to cardiac autonomic neuropathy in a patient with rheumatoid arthritis. ( 27489064 )
2016
18
Erratum to: Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. ( 27376356 )
2016
19
A new cause of silent myocardial infarction: Bonsai. ( 25550251 )
2015
20
A rare long-term survival of the life-threatening trio: silent myocardial infarction complicated by ventricular septal rupture, type 2 diabetes mellitus and chronic bronchitis. ( 26543616 )
2015
21
Silent myocardial infarction and stroke: findings of multimodality imaging. ( 25514927 )
2015
22
Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS) 79. ( 23362315 )
2013
23
Prevalence, extent, and independent predictors of silent myocardial infarction. ( 23597799 )
2013
24
A silent myocardial infarction in the diabetes outpatient clinic: case report and review of the literature. ( 24616778 )
2013
25
An unusual case of left ventricular free wall rupture caused by a silent myocardial infarction. ( 23170099 )
2012
26
Is silent myocardial infarction more common in women with type 2 diabetes than in men? ( 22446034 )
2012
27
Silent myocardial infarction during hypoglycemic coma. ( 22276266 )
2012
28
Silent myocardial infarction subsequent to cutaneous polyarteritis nodosa in a patient with positive lupus anticoagulant. ( 21763578 )
2011
29
Prevalence, incidence, predictive factors and prognosis of silent myocardial infarction: a review of the literature. ( 21497307 )
2011
30
Coronary aneurysm and silent myocardial infarction in an adolescent secondary to undiagnosed childhood Kawasaki disease. ( 20664770 )
2010
31
Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. ( 19797259 )
2010
32
Silent myocardial infarction: the risk beyond the first admission. ( 20813725 )
2010
33
Does silent myocardial infarction add prognostic value in ST-elevation myocardial infarction patients without a history of prior myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Trial. ( 20934561 )
2010
34
Cerebral transient ischemic attack due to left ventricular thrombus formation in a young patient with silent myocardial infarction and normal coronary arteries. ( 18160151 )
2009
35
Giant left ventricular aneurysm and intraventricular septal defect after silent myocardial infarction. ( 19329416 )
2009
36
Silent myocardial infarction in women with type II diabetes mellitus and microalbuminuria. ( 19209251 )
2008
37
The impact of remote patient monitoring in managing silent myocardial infarction in a residential home setting. ( 17584720 )
2007
38
Paradoxical mesentery embolism and silent myocardial infarction in primary antiphospholipid syndrome: a case report. ( 16543157 )
2006
39
Giant left-ventricular pseudoaneurysm following silent myocardial infarction. ( 16428885 )
2006
40
Unruptured giant left ventricular pseudoaneurysm complicating silent myocardial infarction in a diabetic young adult: left ventricular giant pseudoaneurysm after silent myocardial infarction. ( 16015433 )
2005
41
Silent myocardial infarction and its prognosis in a community-based cohort of Type 2 diabetic patients: the Fremantle Diabetes Study. ( 14963648 )
2004
42
Small vessel vasculitis with pulmonary aneurysms and silent myocardial infarction. ( 12869681 )
2003
43
Detection of a silent myocardial infarction with phosphor-31 two-dimensional chemical shift imaging (31P 2-D CSI). ( 12928747 )
2003
44
Silent myocardial infarction in women with impaired glucose tolerance: the Northern Sweden MONICA study. ( 14498994 )
2003
45
Silent myocardial infarction during hypoglycaemic coma. ( 8894868 )
1996
46
Silent myocardial infarction in Wegener's granulomatosis. ( 8612034 )
1996
47
Silent myocardial infarction in Wegener's granulomatosis. ( 7748024 )
1995
48
Infection of left ventricular thrombus in a patient with silent myocardial infarction--a unique complication. ( 8375427 )
1993
49
[Silent myocardial infarction caused by acute carbon monoxide poisoning]. ( 8405820 )
1993
50
Silent myocardial infarction. ( 2320516 )
1990

Variations for Silent Myocardial Infarction

Expression for Silent Myocardial Infarction

Search GEO for disease gene expression data for Silent Myocardial Infarction.

Pathways for Silent Myocardial Infarction

GO Terms for Silent Myocardial Infarction

Biological processes related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.16 AGTR1 TRPV1
2 protein homotetramerization GO:0051289 8.96 GLS TRPV1
3 glutamate secretion GO:0014047 8.62 GLS TRPV1

Molecular functions related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol binding GO:0035091 8.62 NISCH TRPV1

Sources for Silent Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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