MCID: SLN001
MIFTS: 28

Silent Myocardial Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Silent Myocardial Infarction

MalaCards integrated aliases for Silent Myocardial Infarction:

Name: Silent Myocardial Infarction 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5854
NCIt 50 C35400
SNOMED-CT 68 194796000 233843008
UMLS 73 C0340324

Summaries for Silent Myocardial Infarction

MalaCards based summary : Silent Myocardial Infarction is related to myocardial infarction and diabetes mellitus. An important gene associated with Silent Myocardial Infarction is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Chromium and Nitrous oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney.

Related Diseases for Silent Myocardial Infarction

Diseases related to Silent Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 10.7
2 diabetes mellitus 10.1
3 aneurysm 10.0
4 acute myocardial infarction 9.9
5 autonomic neuropathy 9.9
6 neuropathy 9.9
7 atrial standstill 1 9.8
8 rheumatoid arthritis 9.8
9 kawasaki disease 9.8
10 polyarteritis nodosa, childhood-onset 9.8
11 arthritis 9.8
12 chronic kidney failure 9.8
13 coronary artery vasospasm 9.8
14 hypoglycemic coma 9.8
15 ventricular septal defect 9.8
16 transient cerebral ischemia 9.8
17 antiphospholipid syndrome 9.8
18 ischemia 9.8
19 coronary aneurysm 9.8
20 cerebritis 9.8
21 kidney disease 9.8
22 bronchitis 9.8
23 peptic ulcer disease 9.8
24 vasculitis 9.8
25 dextrocardia 9.8
26 polyarteritis nodosa 9.8
27 cutaneous polyarteritis nodosa 9.8
28 arteries, anomalies of 9.4 AGTR1 TRPV1

Graphical network of the top 20 diseases related to Silent Myocardial Infarction:



Diseases related to Silent Myocardial Infarction

Symptoms & Phenotypes for Silent Myocardial Infarction

Drugs & Therapeutics for Silent Myocardial Infarction

Drugs for Silent Myocardial Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chromium Approved Phase 4 7440-47-3 27668
2
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
3
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
4
Metformin Approved Phase 4 657-24-9 14219 4091
5
Gliclazide Approved Phase 4 21187-98-4 3475
6
Glyburide Approved Phase 4 10238-21-8 3488
7
Glimepiride Approved Phase 4,Phase 3 93479-97-1 3476
8
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
9
Cobalt Phase 4 7440-48-4 104729
10 Micronutrients Phase 4
11 Trace Elements Phase 4
12 Analgesics Phase 4
13 Central Nervous System Depressants Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Anesthetics Phase 4
16 Anesthetics, General Phase 4
17 Anesthetics, Inhalation Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Hypoglycemic Agents Phase 4,Phase 3
20
Warfarin Approved Phase 3 81-81-2 6691 54678486
21
Empagliflozin Approved Phase 3 864070-44-0
22
Linagliptin Approved Phase 3 668270-12-0 10096344
23
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
24 Nutmeg Approved, Nutraceutical Phase 3
25
Darapladib Investigational Phase 3 356057-34-6 9939609
26 Dabigatran Phase 3
27
protease inhibitors Phase 3
28 Serine Proteinase Inhibitors Phase 3
29 HIV Protease Inhibitors Phase 3
30 Anticoagulants Phase 3
31 Antithrombin III Phase 3
32 Antithrombins Phase 3
33 Hormone Antagonists Phase 3
34 Dipeptidyl-Peptidase IV Inhibitors Phase 3
35 Hormones Phase 3
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
37 Anti-Arrhythmia Agents Phase 3
38 Immunosuppressive Agents Phase 3
39 Incretins Phase 3
40 Mace Nutraceutical Phase 3

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII Unknown status NCT01918150 Phase 4
2 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial Completed NCT00430989 Phase 4 Nitrous Oxide;Nitrous Oxide
3 Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial Active, not recruiting NCT00700856 Phase 4 add-on pioglitazone;add-on sulphonylurea
4 BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). Completed NCT01131676 Phase 3 BI 10773 low dose;Placebo BI 10773 high dose;BI 10773 high dose;Placebo BI 10773 low dose;Placebo BI 10773 low dose;Placebo BI 10773 high dose
5 The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial Completed NCT01000727 Phase 3 Darapladib 160 mg;Placebo
6 The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial Completed NCT00799903 Phase 3 Darapladib;Placebo
7 Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate Completed NCT00262600 Phase 3 warfarin;Dabigatran dose 1;Dabigatran dose 2
8 RELY-ABLE Long Term Multi-center Extension of Dabigatran Treatment in Patients With Atrial Fibrillation Who Completed RE-LY Trial Completed NCT00808067 Phase 3 dabigatran dose 1;dabigatran dose 2
9 CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Active, not recruiting NCT01243424 Phase 3 linagliptin;glimepiride;linagliptin placebo;glimepride placebo
10 MYOCARDIAL SILENT INFARCTIONS AND FIBROSIS IN FAMILIAL HYPERCHOLESTEROLEMIA (CHOLCOEUR) Unknown status NCT02517944
11 Pain Perception is Attenuated in Patients With Painless Myocardial Infarction Completed NCT00192790
12 Microparticles in Obstructive Sleep Apnea Recruiting NCT03438149

Search NIH Clinical Center for Silent Myocardial Infarction

Genetic Tests for Silent Myocardial Infarction

Anatomical Context for Silent Myocardial Infarction

MalaCards organs/tissues related to Silent Myocardial Infarction:

41
Heart, Lung, Kidney

Publications for Silent Myocardial Infarction

Articles related to Silent Myocardial Infarction:

(show top 50) (show all 73)
# Title Authors Year
1
Silent Myocardial Infarction: Listen to the Evidence. ( 29301632 )
2018
2
Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report. ( 29471871 )
2018
3
A Combination of Tachycardia-Mediated Heart Failure and Coronary Artery Vasospasm-Induced Silent Myocardial Infarction in a Patient with Severe Thyrotoxicosis. ( 29713551 )
2018
4
Silent Myocardial Infarction and Long-Term Risk of Heart Failure: The ARIC Study. ( 29301615 )
2018
5
Acute coronary syndromes: Silent myocardial infarction increases the risk of heart failure. ( 29368702 )
2018
6
Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction. ( 29680352 )
2018
7
Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. ( 28515002 )
2017
8
Woven coronary anomaly leading to silent myocardial infarction: A case report. ( 29095260 )
2017
9
Prognostic value of silent myocardial infarction in patients with chronic kidney disease being evaluated for kidney transplantation. ( 28958755 )
2017
10
Race and Sex Differences in the Incidence and Prognostic Significance of Silent Myocardial Infarction in the Atherosclerosis Risk in Communities (ARIC) Study. ( 27185168 )
2016
11
A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes. ( 27300573 )
2016
12
Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report. ( 26925778 )
2016
13
Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. ( 27209284 )
2016
14
Silent myocardial infarction secondary to cardiac autonomic neuropathy in a patient with rheumatoid arthritis. ( 27489064 )
2016
15
A new cause of silent myocardial infarction: Bonsai. ( 25550251 )
2015
16
A rare long-term survival of the life-threatening trio: silent myocardial infarction complicated by ventricular septal rupture, type 2 diabetes mellitus and chronic bronchitis. ( 26543616 )
2015
17
Silent myocardial infarction and stroke: findings of multimodality imaging. ( 25514927 )
2015
18
Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS) 79. ( 23362315 )
2013
19
Prevalence, extent, and independent predictors of silent myocardial infarction. ( 23597799 )
2013
20
A silent myocardial infarction in the diabetes outpatient clinic: case report and review of the literature. ( 24616778 )
2013
21
An unusual case of left ventricular free wall rupture caused by a silent myocardial infarction. ( 23170099 )
2012
22
Is silent myocardial infarction more common in women with type 2 diabetes than in men? ( 22446034 )
2012
23
Silent myocardial infarction during hypoglycemic coma. ( 22276266 )
2012
24
Silent myocardial infarction subsequent to cutaneous polyarteritis nodosa in a patient with positive lupus anticoagulant. ( 21763578 )
2011
25
Prevalence, incidence, predictive factors and prognosis of silent myocardial infarction: a review of the literature. ( 21497307 )
2011
26
Coronary aneurysm and silent myocardial infarction in an adolescent secondary to undiagnosed childhood Kawasaki disease. ( 20664770 )
2010
27
Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. ( 19797259 )
2010
28
Silent myocardial infarction: the risk beyond the first admission. ( 20813725 )
2010
29
Does silent myocardial infarction add prognostic value in ST-elevation myocardial infarction patients without a history of prior myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Trial. ( 20934561 )
2010
30
Cerebral transient ischemic attack due to left ventricular thrombus formation in a young patient with silent myocardial infarction and normal coronary arteries. ( 18160151 )
2009
31
Giant left ventricular aneurysm and intraventricular septal defect after silent myocardial infarction. ( 19329416 )
2009
32
Silent myocardial infarction in women with type II diabetes mellitus and microalbuminuria. ( 19209251 )
2008
33
The impact of remote patient monitoring in managing silent myocardial infarction in a residential home setting. ( 17584720 )
2007
34
Paradoxical mesentery embolism and silent myocardial infarction in primary antiphospholipid syndrome: a case report. ( 16543157 )
2006
35
Giant left-ventricular pseudoaneurysm following silent myocardial infarction. ( 16428885 )
2006
36
Unruptured giant left ventricular pseudoaneurysm complicating silent myocardial infarction in a diabetic young adult: left ventricular giant pseudoaneurysm after silent myocardial infarction. ( 16015433 )
2005
37
Silent myocardial infarction and its prognosis in a community-based cohort of Type 2 diabetic patients: the Fremantle Diabetes Study. ( 14963648 )
2004
38
Small vessel vasculitis with pulmonary aneurysms and silent myocardial infarction. ( 12869681 )
2003
39
Detection of a silent myocardial infarction with phosphor-31 two-dimensional chemical shift imaging (31P 2-D CSI). ( 12928747 )
2003
40
Silent myocardial infarction in women with impaired glucose tolerance: the Northern Sweden MONICA study. ( 14498994 )
2003
41
Silent myocardial infarction during hypoglycaemic coma. ( 8894868 )
1996
42
Silent myocardial infarction in Wegener's granulomatosis. ( 8612034 )
1996
43
Silent myocardial infarction in Wegener's granulomatosis. ( 7748024 )
1995
44
Infection of left ventricular thrombus in a patient with silent myocardial infarction--a unique complication. ( 8375427 )
1993
45
[Silent myocardial infarction caused by acute carbon monoxide poisoning]. ( 8405820 )
1993
46
Silent myocardial infarction. ( 2320516 )
1990
47
Silent myocardial infarction complicated by asymptomatic ventricular septal defect and deferred rupture of left ventricular pseudoaneurysm. ( 15227401 )
1990
48
Myocardial abscess after silent myocardial infarction. ( 2658198 )
1989
49
Silent myocardial infarction discovered during indium-111 white blood cell imaging. ( 3383524 )
1988
50
Utility of echocardiography in diagnosis of ventricular septal rupture following electrocardiographically silent myocardial infarction. ( 3450564 )
1987

Variations for Silent Myocardial Infarction

Expression for Silent Myocardial Infarction

Search GEO for disease gene expression data for Silent Myocardial Infarction.

Pathways for Silent Myocardial Infarction

GO Terms for Silent Myocardial Infarction

Biological processes related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.16 AGTR1 TRPV1
2 protein homotetramerization GO:0051289 8.96 GLS TRPV1
3 glutamate secretion GO:0014047 8.62 GLS TRPV1

Molecular functions related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol binding GO:0035091 8.62 NISCH TRPV1

Sources for Silent Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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