MCID: SLN001
MIFTS: 31

Silent Myocardial Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Silent Myocardial Infarction

MalaCards integrated aliases for Silent Myocardial Infarction:

Name: Silent Myocardial Infarction 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5854
NCIt 49 C35400
UMLS 71 C0340324

Summaries for Silent Myocardial Infarction

MalaCards based summary : Silent Myocardial Infarction is related to mitral valve insufficiency and coronary artery vasospasm. An important gene associated with Silent Myocardial Infarction is TNNT2 (Troponin T2, Cardiac Type), and among its related pathways/superpathways are Folate Metabolism and Dilated cardiomyopathy (DCM). The drugs Cobalt and Chromium have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and skin.

Related Diseases for Silent Myocardial Infarction

Diseases related to Silent Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 mitral valve insufficiency 29.8 TNNT2 TNNI3 CRP ACE
2 coronary artery vasospasm 29.6 TNNI3 CRP ACE
3 cardiac tamponade 29.6 TNNI3 CRP ACE
4 pericardial effusion 29.6 TNNI3 CRP ACE
5 congestive heart failure 29.6 TNNT2 TNNI3 INS CRP ACE
6 pericarditis 29.5 TNNT2 TNNI3 CRP ACE
7 peripheral nervous system disease 29.5 INS CRP ACE
8 left bundle branch hemiblock 29.3 TNNT2 TNNI3 CRP ACE
9 pulmonary edema 29.3 TNNT2 TNNI3 CRP ACE
10 myocardial infarction 29.2 TNNT2 TNNI3 LPA INS CRP APOB
11 coronary heart disease 1 29.0 LPA INS CRP APOB ACE
12 atrial fibrillation 29.0 TNNT2 TNNI3 INS CRP ACE
13 stroke, ischemic 28.9 LPA CRP APOB ACE
14 cerebrovascular disease 28.8 LPA INS CRP APOB ACE
15 patent foramen ovale 28.7 TNNT2 TNNI3 LPA CRP ACE
16 angina pectoris 28.7 TNNI3 LPA INS CRP ACE
17 hypercholesterolemia, familial, 1 28.6 LPA INS CRP APOB ACE
18 atherosclerosis susceptibility 28.6 LPA INS CRP APOB ACE
19 heart disease 28.3 TNNT2 TNNI3 LPA INS CRP APOB
20 kidney disease 28.3 TNNT2 LPA INS CRP APOB ACE
21 acute myocardial infarction 28.1 TNNT2 TNNI3 LPA INS CRP APOB
22 diabetes mellitus 27.9 SLC5A2 REG1A LPA INS CRP APOB
23 intermediate coronary syndrome 27.9 TNNT2 TNNI3 LPA INS CRP APOB
24 chronic kidney disease 27.9 TNNT2 TNNI3 LPA INS CRP APOB
25 acute cystitis 27.8 SLC5A4 SLC5A2 REG1A INS CRP ACE
26 diabetes mellitus, noninsulin-dependent 26.7 SLC5A4 SLC5A2 REG1A LPA INS CRP
27 familial isolated restrictive cardiomyopathy 10.4 TNNT2 TNNI3
28 acidophil adenoma 10.3 TNNI3 INS
29 malignant otitis externa 10.3 INS CRP
30 neurogenic arthropathy 10.3 INS CRP
31 critical illness polyneuropathy 10.3 INS CRP
32 acute insulin response 10.3 INS CRP
33 mediastinitis 10.3 INS CRP
34 kwashiorkor 10.3 INS CRP
35 gastric dilatation 10.3 TNNI3 CRP
36 duodenitis 10.3 INS CRP
37 benign essential hypertension 10.3 INS CRP
38 asphyxia neonatorum 10.3 INS CRP
39 fetal macrosomia 10.3 INS APOB
40 nerve compression syndrome 10.2 INS CRP
41 volvulus of midgut 10.2 TNNI3 CRP
42 hyperlipoproteinemia, type v 10.2 INS APOB
43 decubitus ulcer 10.2 INS CRP
44 aneurysm 10.2
45 intracranial arteriosclerosis 10.2 LPA INS
46 platelet glycoprotein iv deficiency 10.2 INS APOB
47 actinomycosis 10.2 INS CRP
48 riboflavin deficiency 10.2 CRP APOB
49 lactose intolerance 10.2 INS CRP
50 amyloidosis aa 10.2 LPA CRP

Graphical network of the top 20 diseases related to Silent Myocardial Infarction:



Diseases related to Silent Myocardial Infarction

Symptoms & Phenotypes for Silent Myocardial Infarction

Drugs & Therapeutics for Silent Myocardial Infarction

Drugs for Silent Myocardial Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
2
Chromium Approved Phase 4 7440-47-3 27668
3 Nutrients Phase 4
4 Trace Elements Phase 4
5 Micronutrients Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A French, Multicentric, Randomized, Simple Blind, Superiority Study Comparing the Efficiency and the Safety at 24 Months of the Stent Titan2 Versus Bare Metal Stent in Cobalt-Chrome in All Comers Patients Among Which 40 % Present an ACS. Unknown status NCT01918150 Phase 4
2 MYOCARDIAL SILENT INFARCTIONS AND FIBROSIS IN FAMILIAL HYPERCHOLESTEROLEMIA Unknown status NCT02517944
3 Clinical and Experimental Pain Perception is Attenuated in Patients With Painless Myocardial Infarction Completed NCT00192790
4 Incidence of Diabetes and Cardiovascular Disease in Mexican Americans Completed NCT00005205

Search NIH Clinical Center for Silent Myocardial Infarction

Genetic Tests for Silent Myocardial Infarction

Anatomical Context for Silent Myocardial Infarction

MalaCards organs/tissues related to Silent Myocardial Infarction:

40
Heart, Kidney, Skin, Liver, Brain, Lung, Testes

Publications for Silent Myocardial Infarction

Articles related to Silent Myocardial Infarction:

(show top 50) (show all 242)
# Title Authors PMID Year
1
New Q Waves and T-Wave Inversions Following Endovascular Surgery Lead to Diagnosis of Clinically Silent Myocardial Infarction Despite Negative Preoperative Cardiovascular Risk Evaluation: A Case Report. 61
31904627 2020
2
Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial). 61
31648781 2019
3
Silent Myocardial Infarction and Sudden Cardiac Death-Finding the Culprit. 61
31746954 2019
4
Silent Myocardial Infarction and Sudden Cardiac Death-Finding the Culprit-Reply. 61
31746955 2019
5
Reprint of "Electrocardiographic definition of silent myocardial infarction in population studies: A call to standardize the standards". 61
31733805 2019
6
[Diagnosis of diabetic cardiac autonomic neuropathy]. 61
31448646 2019
7
Serum Cotinine and Silent Myocardial Infarction in Individuals Free from Cardiovascular Disease. 61
31272704 2019
8
Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D. 61
31203233 2019
9
Electrocardiographic definition of silent myocardial infarction in population studies: A call to standardize the standards. 61
31170595 2019
10
Association of Silent Myocardial Infarction and Sudden Cardiac Death. 61
31290935 2019
11
A silent myocardial infarction with normal coronary arteries associated with Graves' disease. 61
30503299 2019
12
Silent myocardial infarction and risk of heart failure: Current evidence and gaps in knowledge. 61
30224236 2019
13
Congestive heart failure caused by silent ischemia and silent myocardial infarction : Diagnostic challenge in type 2 diabetes. 61
30899966 2019
14
Incidentally discovered left ventricular pseudoaneurysm after silent myocardial infarction occurred in a young woman with peritoneal dialysis. 61
30859192 2019
15
Interrelations Between Serum Uric Acid, Silent Myocardial Infarction, and Mortality in the General Population. 61
30617009 2019
16
Interrelationships Between American Heart Association's Life's Simple 7, ECG Silent Myocardial Infarction, and Cardiovascular Mortality. 61
30859894 2019
17
One quarter of total myocardial infarctions are silent manifestation in patients with type 2 diabetes mellitus. 61
30487058 2019
18
Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction. 61
29680352 2018
19
Silent myocardial infarction and risk of heart failure. 61
30613610 2018
20
Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy. 61
30196147 2018
21
An unusual etiology of ischemic stroke: Woven coronary artery anomaly. 61
30072841 2018
22
A Case of Left Ventricular Thrombus with Superior Mesenteric Vein Thrombosis Due to Atopic Dermatitis. 61
29877306 2018
23
Unruptured giant left ventricular pseudoaneurysm after silent myocardial infarction. 61
30021745 2018
24
Acute coronary syndromes: Silent myocardial infarction increases the risk of heart failure. 61
29368702 2018
25
Correction: Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report. 61
29471871 2018
26
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment. 61
29359025 2018
27
Silent Myocardial Infarction and Long-Term Risk of Heart Failure: The ARIC Study. 61
29301615 2018
28
Prolonged diabetic ketoacidosis associated with canagliflozin. 61
29899991 2018
29
Silent Myocardial Infarction: Listen to the Evidence. 61
29301632 2018
30
A Combination of Tachycardia-Mediated Heart Failure and Coronary Artery Vasospasm-Induced Silent Myocardial Infarction in a Patient with Severe Thyrotoxicosis. 61
29713551 2018
31
Sickle-cell and alpha-thalassemia traits resulting in non-atherosclerotic myocardial infarction: Beyond coincidence? 61
29291201 2017
32
Prognostic value of silent myocardial infarction in patients with chronic kidney disease being evaluated for kidney transplantation. 61
28958755 2017
33
Woven coronary anomaly leading to silent myocardial infarction: A case report. 61
29095260 2017
34
Reperfusion treatment delays amongst patients with painless ST segment elevation myocardial infarction. 61
27681496 2017
35
Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. 61
28515002 2017
36
Removal of a giant left ventricular thrombus after myocardial infarction due to dissection of left anterior descending artery. 61
28329239 2017
37
SAVOR-TIMI to SUSTAIN-6: a critical comparison of cardiovascular outcome trials of antidiabetic drugs. 61
28121469 2017
38
Systemic Amyloidosis and Cardiac Autonomic Neuropathy Associated with Waldenstrom's Macroglobulinemia. 61
28695027 2017
39
Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. 61
27924924 2016
40
A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes. 61
27300573 2016
41
Erratum to: Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. 61
27376356 2016
42
Silent myocardial infarction secondary to cardiac autonomic neuropathy in a patient with rheumatoid arthritis. 61
27489064 2016
43
Cardiovascular Events in a Physical Activity Intervention Compared With a Successful Aging Intervention: The LIFE Study Randomized Trial. 61
27439082 2016
44
[Prognosis of silent myocardial infarction]. 61
30547496 2016
45
Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. 61
27209284 2016
46
Severe adverse events associated with local anaesthesia in cataract surgery: 1 year national survey of practice and complications in the UK. 61
26405103 2016
47
Race and Sex Differences in the Incidence and Prognostic Significance of Silent Myocardial Infarction in the Atherosclerosis Risk in Communities (ARIC) Study. 61
27185168 2016
48
Sudden death associated with silent myocardial infarction in a 35-year-old man: a case report. 61
26925778 2016
49
Inferior Q waves in apparently healthy subjects: Should we take a deep breath? An electrocardiographic, echocardiographic and cardiac magnetic resonance study. 61
26387880 2016
50
Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction. 61
27144592 2016

Variations for Silent Myocardial Infarction

Expression for Silent Myocardial Infarction

Search GEO for disease gene expression data for Silent Myocardial Infarction.

Pathways for Silent Myocardial Infarction

Pathways related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 INS CRP APOB
2
Show member pathways
11.6 TNNT2 TNNI3 ACE
3 11.26 TNNT2 TNNI3 INS
4 10.52 TNNT2 TNNI3 INS

GO Terms for Silent Myocardial Infarction

Cellular components related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 9.26 INS APOB
2 troponin complex GO:0005861 9.16 TNNT2 TNNI3
3 cardiac myofibril GO:0097512 8.96 TNNT2 TNNI3
4 cardiac Troponin complex GO:1990584 8.62 TNNT2 TNNI3

Biological processes related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 REG1A INS CRP APOB
2 acute-phase response GO:0006953 9.48 INS CRP
3 skeletal muscle contraction GO:0003009 9.46 TNNT2 TNNI3
4 glucose transmembrane transport GO:1904659 9.43 SLC5A4 SLC5A2
5 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.4 TNNT2 TNNI3
6 regulation of muscle contraction GO:0006937 9.32 TNNT2 TNNI3
7 heart contraction GO:0060047 9.26 TNNI3 ACE
8 low-density lipoprotein particle remodeling GO:0034374 9.16 LPA APOB
9 negative regulation of ATPase activity GO:0032780 8.96 TNNT2 TNNI3
10 negative regulation of blood vessel diameter GO:0097756 8.62 INS CRP

Molecular functions related to Silent Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle receptor binding GO:0050750 9.16 CRP APOB
2 glucose:sodium symporter activity GO:0005412 8.96 SLC5A4 SLC5A2
3 troponin C binding GO:0030172 8.62 TNNT2 TNNI3

Sources for Silent Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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