MCID: SLN005
MIFTS: 25

Silent Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Silent Pituitary Adenoma

MalaCards integrated aliases for Silent Pituitary Adenoma:

Name: Silent Pituitary Adenoma 58
Non-Functioning Pituitary Gland Neoplasm 70

Characteristics:

Orphanet epidemiological data:

58
silent pituitary adenoma
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 33 D35.2
Orphanet 58 ORPHA314786
UMLS 70 C0338078

Summaries for Silent Pituitary Adenoma

MalaCards based summary : Silent Pituitary Adenoma, also known as non-functioning pituitary gland neoplasm, is related to pituitary adenoma and pituitary tumors. An important gene associated with Silent Pituitary Adenoma is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Mismatch repair and BRCA1 Pathway. Affiliated tissues include pituitary and prostate, and related phenotypes are cellular and neoplasm

Related Diseases for Silent Pituitary Adenoma

Diseases related to Silent Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 30.4 MEN1 AIP
2 pituitary tumors 30.0 MEN1 AIP
3 pituitary gland disease 29.7 MEN1 AIP
4 adenoma 29.5 MSH6 MSH2 MEN1 AIP
5 cheilitis 10.0 MSH2 CD274
6 extrahepatic bile duct adenoma 10.0 MSH6 MSH2
7 renal pelvis transitional cell carcinoma 10.0 MSH6 MSH2
8 adenosquamous colon carcinoma 10.0 MSH6 MSH2
9 autosomal dominant non-syndromic intellectual disability 8 10.0 MSH6 MSH2
10 appendix carcinoid tumor 10.0 MSH6 MSH2
11 neurofibromatosis 10.0 MSH6 MSH2
12 jejunal cancer 10.0 MSH6 MSH2
13 mismatch repair cancer syndrome 10.0 MSH6 MSH2
14 colorectal cancer, hereditary nonpolyposis, type 6 10.0 MSH6 MSH2
15 esophagus sarcoma 10.0 MSH6 MSH2
16 colorectal cancer, hereditary nonpolyposis, type 5 10.0 MSH6 MSH2
17 sebaceous gland neoplasm 10.0 MSH6 MSH2
18 cervical adenosarcoma 10.0 MSH6 MSH2
19 sebaceous adenoma 10.0 MSH6 MSH2
20 small intestine adenocarcinoma 10.0 MSH6 MSH2
21 duodenum adenocarcinoma 10.0 MSH6 MSH2
22 dysplastic nevus syndrome 10.0 MSH6 MSH2
23 retinoblastoma 10.0
24 body mass index quantitative trait locus 11 10.0
25 body mass index quantitative trait locus 9 10.0
26 body mass index quantitative trait locus 8 10.0
27 body mass index quantitative trait locus 4 10.0
28 body mass index quantitative trait locus 10 10.0
29 body mass index quantitative trait locus 7 10.0
30 body mass index quantitative trait locus 12 10.0
31 body mass index quantitative trait locus 14 10.0
32 body mass index quantitative trait locus 18 10.0
33 body mass index quantitative trait locus 19 10.0
34 ptosis 10.0
35 amenorrhea 10.0
36 lipid metabolism disorder 10.0
37 craniopharyngioma 10.0
38 functioning gonadotropic adenoma 10.0
39 attenuated familial adenomatous polyposis 10.0 MSH6 MSH2
40 familial adenomatous polyposis 10.0 MSH6 MSH2
41 female reproductive endometrioid cancer 10.0 MSH6 MSH2
42 legius syndrome 10.0 MSH6 MSH2
43 breast-ovarian cancer, familial 1 10.0 MSH6 MSH2
44 mismatch repair cancer syndrome 1 10.0 MSH6 MSH2
45 pituitary carcinoma 10.0 MSH6 MEN1
46 sebaceous adenocarcinoma 10.0 MSH6 MSH2
47 cecum carcinoma 10.0 MSH6 MSH2
48 hereditary nonpolyposis colon cancer 10.0 MSH6 MSH2
49 hereditary mixed polyposis syndrome 10.0 MSH6 MSH2
50 muir-torre syndrome 9.9 MSH6 MSH2

Graphical network of the top 20 diseases related to Silent Pituitary Adenoma:



Diseases related to Silent Pituitary Adenoma

Symptoms & Phenotypes for Silent Pituitary Adenoma

MGI Mouse Phenotypes related to Silent Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 AIP CD274 MEN1 MSH2 MSH6
2 neoplasm MP:0002006 8.92 AIP MEN1 MSH2 MSH6

Drugs & Therapeutics for Silent Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Silent Pituitary Adenoma

Genetic Tests for Silent Pituitary Adenoma

Anatomical Context for Silent Pituitary Adenoma

MalaCards organs/tissues related to Silent Pituitary Adenoma:

40
Pituitary, Prostate

Publications for Silent Pituitary Adenoma

Articles related to Silent Pituitary Adenoma:

(show all 14)
# Title Authors PMID Year
1
Silent pituitary adenoma and metabolic disorders: obesity, abnormal glucose tolerance, hypertension and dyslipidemia. 61
33028757 2021
2
Clinical Relevance and Immunohistochemical Patterns of Silent Pituitary Adenomas: 10 Years of Single-centre Experience. 61
33357196 2021
3
MSH6/2 and PD-L1 Expressions Are Associated with Tumor Growth and Invasiveness in Silent Pituitary Adenoma Subtypes. 61
32325698 2020
4
Function of cell-cycle regulators in predicting silent pituitary adenoma progression following surgical resection. 61
29344143 2017
5
Gangliocytoma: outcome of a rare silent pituitary tumour. 61
28232376 2017
6
Silent pituitary adenomas. 61
25732644 2015
7
Silent (clinically nonfunctioning) pituitary adenomas. 61
24676675 2014
8
Male gonadotroph adenoma: report of three cases and a review of the literature. 61
23728555 2013
9
Intracranial tumors in Kuwait: a 15-year survey. 61
21136281 2011
10
Isolated sixth cranial nerve palsy as the presenting symptom of a rapidly expanding ACTH positive pituitary adenoma: a case report. 61
21272327 2011
11
Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report. 61
19238590 2009
12
Apoplexy of clinically silent pituitary adenoma during prostate cancer treatment with LHRH analog. 61
17159826 2006
13
[Pituitary adenoma revealed by Traquair's syndrome]. 61
1340691 1992
14
Reduced size of a hormonally silent pituitary adenoma during treatment with CV 205-502, a new dopamine agonist mainly stimulating D2 receptors. 61
2532309 1989

Variations for Silent Pituitary Adenoma

Expression for Silent Pituitary Adenoma

Search GEO for disease gene expression data for Silent Pituitary Adenoma.

Pathways for Silent Pituitary Adenoma

Pathways related to Silent Pituitary Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 MSH6 MSH2
2
Show member pathways
11.18 MSH6 MSH2
3 11.02 MSH6 MSH2
4 10.62 MSH6 MSH2
5 10.09 MSH6 MSH2

GO Terms for Silent Pituitary Adenoma

Cellular components related to Silent Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.55 MSH6 MSH2 MEN1 CD274 AIP
2 mismatch repair complex GO:0032300 8.96 MSH6 MSH2
3 MutSalpha complex GO:0032301 8.62 MSH6 MSH2

Biological processes related to Silent Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.69 MSH6 MSH2 MEN1
2 DNA repair GO:0006281 9.65 MSH6 MSH2 MEN1
3 response to UV GO:0009411 9.49 MSH6 MEN1
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 MSH6 MSH2
5 mismatch repair GO:0006298 9.43 MSH6 MSH2
6 determination of adult lifespan GO:0008340 9.4 MSH6 MSH2
7 negative regulation of DNA recombination GO:0045910 9.37 MSH6 MSH2
8 isotype switching GO:0045190 9.32 MSH6 MSH2
9 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 MSH6 MSH2
10 positive regulation of helicase activity GO:0051096 9.16 MSH6 MSH2
11 maintenance of DNA repeat elements GO:0043570 8.96 MSH6 MSH2
12 somatic recombination of immunoglobulin gene segments GO:0016447 8.62 MSH6 MSH2

Molecular functions related to Silent Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.67 MSH6 MSH2 MEN1
2 double-stranded DNA binding GO:0003690 9.58 MSH6 MSH2 MEN1
3 damaged DNA binding GO:0003684 9.51 MSH6 MSH2
4 ADP binding GO:0043531 9.48 MSH6 MSH2
5 DNA-dependent ATPase activity GO:0008094 9.46 MSH6 MSH2
6 mismatched DNA binding GO:0030983 9.43 MSH6 MSH2
7 MutLalpha complex binding GO:0032405 9.37 MSH6 MSH2
8 oxidized purine DNA binding GO:0032357 9.32 MSH6 MSH2
9 guanine/thymine mispair binding GO:0032137 9.26 MSH6 MSH2
10 single guanine insertion binding GO:0032142 9.16 MSH6 MSH2
11 single thymine insertion binding GO:0032143 8.96 MSH6 MSH2
12 four-way junction DNA binding GO:0000400 8.8 MSH6 MSH2 MEN1

Sources for Silent Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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