MCID: SLN005
MIFTS: 24

Silent Pituitary Adenoma

Categories: Endocrine diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Silent Pituitary Adenoma

MalaCards integrated aliases for Silent Pituitary Adenoma:

Name: Silent Pituitary Adenoma 59
Non-Functioning Pituitary Gland Neoplasm 73

Characteristics:

Orphanet epidemiological data:

59
silent pituitary adenoma
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare endocrine diseases


External Ids:

Orphanet 59 ORPHA314786
ICD10 via Orphanet 34 D35.2

Summaries for Silent Pituitary Adenoma

MalaCards based summary : Silent Pituitary Adenoma, also known as non-functioning pituitary gland neoplasm, is related to adenoma and pituitary adenoma. An important gene associated with Silent Pituitary Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways is Aldosterone synthesis and secretion. The drugs Dopamine and Cabergoline have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and prostate, and related phenotype is neoplasm.

Related Diseases for Silent Pituitary Adenoma

Diseases related to Silent Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 adenoma 28.8 AIP MEN1
2 pituitary adenoma 10.2
3 prostate cancer 9.8
4 prostatitis 9.8
5 craniopharyngioma 9.8
6 null pituitary adenoma 9.7 AIP MEN1
7 hormone producing pituitary cancer 9.6 AIP MEN1
8 multiple endocrine neoplasia, type iv 9.6 AIP MEN1
9 functioning pituitary adenoma 9.6 AIP MEN1
10 endocrine organ benign neoplasm 9.6 AIP MEN1
11 carney complex variant 9.6 AIP MEN1
12 pituitary tumors 9.5 AIP MEN1
13 organ system benign neoplasm 9.5 AIP MEN1
14 cell type benign neoplasm 9.4 AIP MEN1
15 pituitary adenoma, prolactin-secreting 9.3 AIP MEN1
16 acromegaly 9.2 AIP MEN1

Graphical network of the top 20 diseases related to Silent Pituitary Adenoma:



Diseases related to Silent Pituitary Adenoma

Symptoms & Phenotypes for Silent Pituitary Adenoma

MGI Mouse Phenotypes related to Silent Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 AIP MEN1

Drugs & Therapeutics for Silent Pituitary Adenoma

Drugs for Silent Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Cabergoline Approved Phase 3,Phase 2 81409-90-7 54746
3
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
4
Somatostatin Approved, Investigational Phase 2, Phase 3,Phase 1 38916-34-6, 51110-01-1 53481605
5 Dopamine agonists Phase 3,Phase 2
6 Gastrointestinal Agents Phase 3,Phase 1
7 Neurotransmitter Agents Phase 3,Phase 2
8 Hormone Antagonists Phase 2, Phase 3
9 Hormones Phase 2, Phase 3,Phase 1
10 Dopamine Agents Phase 3,Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
12 Edotreotide Phase 3,Phase 1
13 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
14 Protective Agents Phase 2, Phase 3,Phase 3
15 Antiparkinson Agents Phase 3,Phase 2
16 Radiopharmaceuticals Phase 3,Phase 1
17 Autonomic Agents Phase 2, Phase 3,Phase 3
18 Antineoplastic Agents, Hormonal Phase 3,Phase 1
19
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
20
Maleic acid Experimental Phase 2 110-16-7 444266
21 Adrenocorticotropic Hormone Phase 2
22 Hypoglycemic Agents Phase 2
23 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
24
Menthol Approved 2216-51-5 16666
25 Calcium, Dietary

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Cabergoline in Nonfunctioning Pituitary Adenomas Completed NCT03271918 Phase 3 Cabergoline
2 Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant Prolactinomas Completed NCT01620138 Phase 2, Phase 3 Pasireotide;cabergoline
3 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas Recruiting NCT02288962 Phase 3 cabergoline
4 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
5 Evaluate the Efficacy and Safety of Pasireotide LAR on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma. Completed NCT01283542 Phase 2 Pasireotide LAR
6 Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors Recruiting NCT02749227 Phase 2 Pasireotide LAR
7 Rosiglitazone in Treating Patients With Pituitary Tumors Terminated NCT00616642 Phase 2 rosiglitazone maleate
8 Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas Withdrawn NCT01203618 Phase 2 Farletuzumab
9 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
10 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
11 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
12 Characterization of Receptors in Non-functioning Pituitary Macroadenomas Unknown status NCT00852501
13 Calcium Homeostasis in Acromegaly: Effect of Surgical/Medical Treatment and Comparison With Nonfunctioning Pituitary Tumors Completed NCT01568359
14 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
15 Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia Recruiting NCT03465423
16 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Recruiting NCT01556230
17 Predictive Factors of Recurrence of Non Functioning Pituitary Adenomas : a Retrospective Study of 220 Patients in the Reims University Hospital, France Recruiting NCT02803697
18 Transsphenoidal Extent of Resection Study Recruiting NCT02357498 Not Applicable
19 Seoul National University Pituitary Disease Cohort Study Recruiting NCT03474601

Search NIH Clinical Center for Silent Pituitary Adenoma

Genetic Tests for Silent Pituitary Adenoma

Anatomical Context for Silent Pituitary Adenoma

MalaCards organs/tissues related to Silent Pituitary Adenoma:

41
Pituitary, Brain, Prostate

Publications for Silent Pituitary Adenoma

Articles related to Silent Pituitary Adenoma:

# Title Authors Year
1
Function of cell-cycle regulators in predicting silent pituitary adenoma progression following surgical resection. ( 29344143 )
2017
2
Modification of hormonal secretion in clinically silent pituitary adenomas. ( 18350381 )
2009
3
Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report. ( 19238590 )
2009
4
Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas. ( 16421738 )
2006
5
Apoplexy of clinically silent pituitary adenoma during prostate cancer treatment with LHRH analog. ( 17159826 )
2006
6
Widespread occurrence of chromogranins/secretogranins in the matrix of secretory granules of endocrinologically silent pituitary adenomas. ( 1552186 )
1992
7
Reduced size of a hormonally silent pituitary adenoma during treatment with CV 205-502, a new dopamine agonist mainly stimulating D2 receptors. ( 2532309 )
1989

Variations for Silent Pituitary Adenoma

Expression for Silent Pituitary Adenoma

Search GEO for disease gene expression data for Silent Pituitary Adenoma.

Pathways for Silent Pituitary Adenoma

Pathways related to Silent Pituitary Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.48 AIP MEN1

GO Terms for Silent Pituitary Adenoma

Sources for Silent Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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