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MCID: SLC006
MIFTS: 56

Silicosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Silicosis

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MalaCards integrated aliases for Silicosis:

Name: Silicosis 12 74 52 54 43 15 17 71
Silicotuberculosis 12 71
Chronic Silicosis 52 71
Acute Silicosis 52 71
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 52
Silica Pneumoconiosis 12
Accelerated Silicosis 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10325
ICD9CM 34 502
MeSH 43 D012829
NCIt 49 C3369
SNOMED-CT 67 805002
ICD10 32 J62 J62.8
UMLS 71 C0037116 C0037118 C0340190 more
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Summaries for Silicosis

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NIH Rare Diseases : 52 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to anthracosis and pulmonary fibrosis. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Rifapentine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 74 Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. It is... more...

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Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 669)
# Related Disease Score Top Affiliating Genes
1 anthracosis 33.1 TNF TGFB1 NLRP3 CCL2
2 pulmonary fibrosis 31.5 TGFB1 IL1B CXCL8 CCL2
3 idiopathic interstitial pneumonia 31.3 TGFB1 IL4 CXCL8 CCL2
4 bronchitis 31.3 TNF IL4 IL1B IL10 CXCL8
5 bronchopneumonia 30.7 TNF IL10 CXCL8
6 mycobacterium tuberculosis 1 30.7 TNF IL4 IL18 IL17A IL10
7 pulmonary alveolar proteinosis 30.7 TNF IL10 CXCL8 CCL2
8 interstitial lung disease 30.7 TNF TGFB1 IL4 IL1B IL1A IL18
9 bagassosis 30.7 TNF IL1B CXCL8
10 mycobacterium kansasii 30.6 NLRP3 CXCL8
11 systemic scleroderma 30.5 TNF TGFB1 IL4 IL17A ACE
12 pleural disease 30.5 TNF IL1B CXCL8
13 pemphigus 30.5 TNF IL4 IL10 DSG1
14 rheumatic disease 30.4 TNF IL1RN IL1B IL18 IL10
15 histiocytosis 30.4 TNF IL1RN IL17A
16 autoimmune lymphoproliferative syndrome 30.4 TNF IL10 FASLG FAS
17 glomerulonephritis 30.4 TGFB1 SCGB1A1 IL1B CCL2 ACE
18 pulmonary tuberculosis 30.3 TNF IL4 IL18 IL17A IL10 CCL2
19 endocarditis 30.3 TNF IL17A IL10 CXCL8
20 paracoccidioidomycosis 30.3 TNF IL4 IL10
21 pericarditis 30.3 TNF IL1RN IL1B CXCL8 ACE
22 allergic hypersensitivity disease 30.2 TNF IL4 IL17A IL10 CXCL8
23 end stage renal failure 30.2 TNF TGFB1 IL1RN ACE
24 respiratory failure 30.2 TNF SCGB1A1 IL1RN IL1B IL10 CXCL8
25 mycetoma 30.1 IL17A IL10 CXCL8
26 purpura 30.1 TNF IL4 IL10 ACE
27 pulmonary sarcoidosis 30.1 TNF IL18 CCL2 ACE
28 pleurisy 30.1 TNF TGFB1 IL1RN CXCL8 CCL2
29 dysentery 30.1 TNF IL1B IL1A IL10 CXCL8
30 peptic ulcer disease 30.1 TNF IL1RN IL1B IL10 CXCL8
31 bronchiolitis obliterans 30.0 TNF SCGB1A1 IL17A IL10 CXCL8
32 pharyngitis 30.0 TNF NLRP3 IL1RN IL1B CXCL8
33 cryptococcosis 29.9 TNF IL4 IL17A IL10
34 pulmonary hypertension 29.9 TNF IL1B HMOX1 CXCL8 CCL2 ACE
35 aspergillosis 29.9 TNF IL4 IL1RN IL1B IL18 IL10
36 extrapulmonary tuberculosis 29.9 TNF IL1RN IL1B IL10 CCL2
37 sarcoidosis 1 29.9 TNF SCGB1A1 IL1RN IL1B IL1A IL18
38 toxic shock syndrome 29.8 TNF IL4 IL1RN IL1B IL10 CXCL8
39 lymphopenia 29.8 IL4 IL18 IL10 FASLG FAS
40 collagen disease 29.8 TNF IL4 IL17A IL10 ACE
41 bacterial pneumonia 29.8 TNF SCGB1A1 IL17A IL10 CXCL8
42 adult respiratory distress syndrome 29.7 TNF IL1B IL10 CXCL8 ACE
43 synovitis 29.7 TNF IL1RN IL1B IL1A IL18 CXCL8
44 crescentic glomerulonephritis 29.6 TNFRSF6B SCGB1A1 IL1RN CCL2
45 bronchiolitis 29.6 TNF SCGB1A1 IL4 IL17A IL10 CXCL8
46 lymphadenitis 29.5 TNF IL1B IL18 IL10 FASLG FAS
47 lichen planus 29.4 TNF IL4 IL17A IL10 DSG1 CXCL8
48 chronic kidney disease 29.4 TNF TGFB1 IL10 HMOX1 CCL2 ACE
49 kidney disease 29.3 TNF TGFB1 IL18 HMOX1 CCL2 ACE
50 pneumoconiosis 29.2 TNF TGFB1 SCGB1A1 NLRP3 IL4 IL1RN

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis
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Symptoms & Phenotypes for Silicosis

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GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.08 ACE CASP1 CXCL8 FAS HMOX1 IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.08 ACE CASP1 CXCL8 FAS HMOX1 IL10
3 Decreased ionizing radiation sensitivity GR00232-A-1 9.76 ACE CASP1 DSG1 FAS IL10 IL1B
4 Reduced mammosphere formation GR00396-S 9.5 CASP1 CCL2 CXCL8 FAS FASLG IL17A

MGI Mouse Phenotypes related to Silicosis:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 ACE CASP1 FAS FASLG HMOX1 IL10
2 immune system MP:0005387 10.39 ACE CASP1 CCL2 FAS FASLG HMOX1
3 homeostasis/metabolism MP:0005376 10.38 ACE CASP1 FAS FASLG HMOX1 IL10
4 growth/size/body region MP:0005378 10.36 ACE DSG1 FAS HMOX1 IL10 IL17A
5 cardiovascular system MP:0005385 10.35 ACE CASP1 FAS FASLG HMOX1 IL10
6 cellular MP:0005384 10.34 CASP1 FAS FASLG HMOX1 IL10 IL18
7 integument MP:0010771 10.28 CASP1 DSG1 FAS FASLG IL10 IL17A
8 endocrine/exocrine gland MP:0005379 10.26 ACE CASP1 FAS FASLG HMOX1 IL10
9 digestive/alimentary MP:0005381 10.24 CASP1 FAS FASLG IL10 IL17A IL18
10 mortality/aging MP:0010768 10.24 ACE CASP1 FAS FASLG HMOX1 IL10
11 adipose tissue MP:0005375 10.12 ACE DSG1 HMOX1 IL18 NLRP3 TGFB1
12 craniofacial MP:0005382 10.09 FAS IL10 IL17A IL1B IL4 TGFB1
13 liver/biliary system MP:0005370 10.06 ACE FAS FASLG HMOX1 IL10 IL4
14 neoplasm MP:0002006 10.02 ACE CASP1 FAS FASLG IL10 IL1A
15 renal/urinary system MP:0005367 9.96 ACE CASP1 FAS FASLG HMOX1 IL17A
16 reproductive system MP:0005389 9.9 ACE CASP1 FAS FASLG HMOX1 IL10
17 respiratory system MP:0005388 9.61 FAS FASLG HMOX1 IL10 IL17A IL4
18 skeleton MP:0005390 9.36 DSG1 FAS FASLG IL10 IL17A IL1B
Sources

Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
3
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
4 Antitubercular Agents Phase 3
5 Cytochrome P-450 CYP3A Inducers Phase 3
6 Hypolipidemic Agents Phase 3
7 Antibiotics, Antitubercular Phase 3
8 Anti-Bacterial Agents Phase 3
9 Lipid Regulating Agents Phase 3
10 Antimetabolites Phase 3
11
Nintedanib Approved Phase 2 656247-17-5 56843413
12 Mitogens Phase 1, Phase 2
13
Cocaine Approved, Illicit 50-36-2 5760 446220
14 Respiratory System Agents
15 Anti-Infective Agents
16
protease inhibitors
17 HIV Protease Inhibitors
18 Anesthetics
19 Antiviral Agents
20 Anti-Retroviral Agents
21 Anti-HIV Agents

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Effectiveness and Tolerability of Weekly Rifapentine/Isoniazid for 3 Months for Tuberculosis Preventive Treatment: A Randomized Controlled Study in China Unknown status NCT02430259 Phase 3 Weekly INH / RRT given by DOT
2 Phase 1 Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Not yet recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
4 Phase-1 Study of Autologous Bone Marrow Cells Intrabronchial Instillation for Patients Silicosis Completed NCT01239862 Phase 1
5 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
6 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
7 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
8 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
9 The Use of Forced Oscillation Technique in the Analysis of Respiratory System in Never-smoking Patients With Silicosis:Pathophysiological Study and Evaluation of Diagnostic Accuracy Completed NCT01725971
10 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
11 Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB) Recruiting NCT03900858 Isoniazidï¼›Rifapentine
12 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Enrolling by invitation NCT04205708
13 Respiratory Impairment in Mucopolysaccharidosis Patients: Impact of Glycosaminoglycans (GAG) on the Proteases/Antiproteases Balance Not yet recruiting NCT04112602

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

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Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

40
Lung, Testes, Heart, Bone, Lymph Node, Liver, Skin
Sources

Publications for Silicosis

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Articles related to Silicosis:

(show top 50) (show all 5586)
# Title Authors PMID Year
1
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. 54 61
18666137 2008
2
[Polymorphisms of FAS and FASL genes and susceptibility of silicosis]. 54 61
18302883 2008
3
Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis. 54 61
17693780 2007
4
Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages. 54 61
17393098 2007
5
[Changes of Clara cell protein and surfactant protein-D in serum of patients with silicosis]. 54 61
17374182 2007
6
Apoptosis and extracellular matrix remodelling in human silicosis. 54 61
16918975 2006
7
Alterations of Fas and Fas-related molecules in patients with silicosis. 54 61
16636300 2006
8
Detection, epitope-mapping and function of anti-Fas autoantibody in patients with silicosis. 54 61
16108814 2005
9
[Sudy on the activation of early growth response factor-1 by silica dioxide and its signal pathway]. 54 61
16181552 2005
10
[Dysregulation of Fas and related molecules in silicosis patients]. 54 61
15773295 2005
11
[The role of Egr-1 and NF-kappaB in the pathogenesis of silicosis: an in-vitro study]. 54 61
15363325 2004
12
The central role of Fas-ligand cell signaling in inflammatory lung diseases. 54 61
15491504 2004
13
[Expression of early growth response gene-1 in macrophages stimulated by silicon dioxide]. 54 61
14761604 2003
14
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. 54 61
14514471 2003
15
Significance of genetic information in risk assessment and individual classification using silicosis as a case model. 54 61
12176706 2002
16
Polymorphisms of the IL-1 gene complex in coal miners with silicosis. 54 61
11241561 2001
17
Antidesmoglein autoantibodies in silicosis patients with no bullous diseases. 54 61
11244222 2001
18
Detection of alternatively spliced variant messages of Fas gene and mutational screening of Fas and Fas ligand coding regions in peripheral blood mononuclear cells derived from silicosis patients. 54 61
10841950 2000
19
Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients. 54 61
10632670 2000
20
Serum levels of soluble Fas ligand in patients with silicosis. 54 61
10594565 1999
21
Soluble Fas mRNA is dominantly expressed in cases with silicosis. 54 61
9741350 1998
22
Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumours. 54 61
9367417 1997
23
Autophagy, an important therapeutic target for pulmonary fibrosis diseases. 61
31877297 2020
24
Occupational lung diseases in the 21st century: the changing landscape and future challenges. 61
31895883 2020
25
Assessment of silica dust exposure profile in relation to prevalence of silicosis among Indian sandstone mine workers: Need for review of standards. 61
31773774 2020
26
Erratum to Silicosis in Artificial Quartz Conglomerate Workers [Arch Bronconeumol. 2019;55(9):459-464]. 61
32033756 2020
27
Differential expression of lncRNAs during silicosis and the role of LOC103691771 in myofibroblast differentiation induced by TGF-β1. 61
32028236 2020
28
High risk of activation of latent tuberculosis infection in rheumatic disease patients. 61
31656117 2020
29
Preventive tuberculosis treatment effect on QuantiFERON TB-Gold in-tube testing in a high tuberculosis-endemic country: A clinical trial. 61
31770617 2020
30
Overexpression of endogenous lipoic acid synthase attenuates pulmonary fibrosis induced by crystalline silica in mice. 61
32017981 2020
31
PolyG mitigates silica-induced pulmonary fibrosis by inhibiting nucleolin and regulating DNA damage repair pathway. 61
32036217 2020
32
Silicosis: An ancient disease in need of a dose of modern medicine. 61
31970870 2020
33
MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release. 61
31676289 2020
34
Aluminum in the lungs of Ontario hardrock miners. 61
30741110 2020
35
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages. 61
31947943 2020
36
Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen. 61
31953962 2020
37
Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects. 61
31692000 2020
38
MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling. 61
32004504 2020
39
Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway. 61
31706104 2020
40
The potential of mesenchymal stem cell therapy for chronic lung disease. 61
31608724 2020
41
High incidence of radiation pneumonitis in lung cancer patients with chronic silicosis treated with radiotherapy. 61
31822893 2020
42
Silica-related diseases in the modern world. 61
31989662 2020
43
A woman and her breathtaking jewelry. 61
31960767 2020
44
Silicosis in rhinestone-manufacturing workers in South China. 61
31504839 2019
45
Artificial stone-associated silicosis in China: A prospective comparison with natural stone-associated silicosis. 61
31828940 2019
46
Stonemasons with silicosis: Preliminary findings and a warning message from Australia. 61
31407419 2019
47
Accelerated silicosis with bone marrow, hepatic and splenic involvement in a patient with lung transplantation. 61
31831514 2019
48
Silica-associated lung disease: An old-world exposure in modern industries. 61
31517432 2019
49
Upregulation of Slc26a4 in the Early Development of Silicosis via GEO Database Analysis in vivo and in vitro. 61
31918801 2019
50
Nonlinear dose-time-response functions and health-protective exposure limits for inflammation-mediated diseases. 61
31927297 2019
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Variations for Silicosis

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Expression for Silicosis

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Search GEO for disease gene expression data for Silicosis.
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Pathways for Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.13 TNFRSF6B TNF TGFB1 NLRP3 IL4 IL1RN
2
ERK Signaling 63
Show member pathways
 13.95 TNFRSF6B TNF TGFB1 IL4 IL1B IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.77 TNFRSF6B TNF TGFB1 IL4 IL1RN IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.66 TNF TGFB1 IL4 IL1B IL1A IL18
5
Akt Signaling 63
Show member pathways
 13.56 TNF TGFB1 IL4 IL1B IL1A IL18
6
PAK Pathway 63
Show member pathways
 13.4 TNF TGFB1 IL4 IL1B IL1A IL18
7
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.25 TNF TGFB1 NLRP3 IL1B IL18 IL10
8
Cytokine Signaling in Immune system 65
Show member pathways
 13.24 TNFRSF6B TNF TGFB1 IL4 IL1RN IL1B
9
Human cytomegalovirus infection 36
Show member pathways
 13.02 TNF IL1B FASLG FAS CXCL8 CCL2
10
Allograft rejection 1 36
Show member pathways
 13.02 TNF TGFB1 IL4 IL1B IL1A IL17A
11
TNFR1 Pathway 63
Show member pathways
 13.01 TNFRSF6B TNF FASLG FAS CCL2 CASP1
12
Measles 36
Show member pathways
 12.97 TNF NLRP3 IL1B IL1A IL18 FASLG
13
Pathways in cancer 36
12.94 TGFB1 IL4 HMOX1 FASLG FAS CXCL8
14
MAPK signaling pathway 36 1
12.91 TNF TGFB1 IL1B IL1A FASLG FAS
15
Apoptosis Modulation and Signaling 1
Show member pathways
 12.86 TNFRSF6B TNF FASLG FAS CASP1
16
Herpes simplex virus 1 infection 36
12.85 TNF IL1B FASLG FAS CCL2
17
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.82 TNF IL1B IL18 CXCL8 CASP1
18
T cell receptor signaling pathway 36
Show member pathways
 12.8 TNF TGFB1 IL4 IL1B IL1A IL17A
19
Th17 cell differentiation 36
Show member pathways
 12.79 TNF TGFB1 IL4 IL1B IL1A IL18
20
4-1BB Pathway 63
Show member pathways
 12.74 TNF IL1B IL1A FASLG FAS
21
Immune response IL-23 signaling pathway 22
Show member pathways
 12.73 TNF IL1B IL18 IL17A IL10 CCL2
22
TRAF Pathway 63
Show member pathways
 12.72 TNF IL1B IL1A FASLG FAS CASP1
23
NF-kappaB Signaling 4
12.62 TNF IL4 IL1RN IL1B IL17A IL10
24
Shigellosis 36
12.55 TNF NLRP3 IL1B IL18 CXCL8 CASP1
25
IL-17 Family Signaling Pathways 64
Show member pathways
 12.5 TNF IL4 IL1B IL17A CXCL8 CCL2
26
Pathogenic Escherichia coli infection 36
12.49 TNF NLRP3 IL1B IL18 FASLG FAS
27
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.47 TNF IL18 IL10 CXCL8 CCL2
28
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.45 TNF TGFB1 IL4 IL1B IL1A IL18
29
IL-1 signaling pathway 1
Show member pathways
 12.44 IL1RN IL1B IL1A CCL2 CASP1
30
Toxoplasmosis 36
Show member pathways
 12.44 TNF TGFB1 IL4 IL1B IL1A IL10
31
NOD-like receptor signaling pathway 36
12.44 TNF NLRP3 IL1B IL18 CXCL8 CCL2
32
IL-1 Family Signaling Pathways 64
Show member pathways
 12.42 TNF IL1RN IL1B IL1A IL18 HMOX1
33
Tuberculosis 36
12.41 TNF TGFB1 IL1B IL1A IL18 IL10
34
Necroptosis 36
Show member pathways
 12.4 TNF NLRP3 IL1B IL1A FASLG FAS
35
Folate Metabolism 1
Show member pathways
 12.39 TNF IL4 IL1B CCL2
36
Apoptosis and Autophagy 4
12.39 TNFRSF6B TNF FASLG FAS CASP1
37
Apoptosis and survival Caspase cascade 22
Show member pathways
 12.37 TNF IL1A FASLG FAS CASP1
38
Bacterial infections in CF airways 22
Show member pathways
 12.37 TNF IL4 IL1B FASLG FAS CXCL8
39
Proteoglycans in cancer 36
12.36 TNF TGFB1 FASLG FAS
40
C-type lectin receptor signaling pathway 36
Show member pathways
 12.36 TNF NLRP3 IL1B IL10 CASP1
41
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.36 TNF IL1RN IL1B IL1A IL10 CXCL8
42
Fluid shear stress and atherosclerosis 36
12.25 TNF IL1B IL1A HMOX1 CCL2
43
Th1 Differentiation Pathway 64
Show member pathways
 12.25 TNF TGFB1 IL1B IL18 IL17A IL10
44
Spinal Cord Injury 1
12.22 TNF TGFB1 IL4 IL1B IL1A CXCL8
45
Osteoclast differentiation 36
12.15 TNF TGFB1 IL1B IL1A
46
AGE-RAGE signaling pathway in diabetic complications 36
12.14 TNF TGFB1 IL1B IL1A CXCL8 CCL2
47
Yersinia infection 36
12.11 TNF NLRP3 IL1B IL18 IL10 CXCL8
48
Amoebiasis 36
12.1 TNF TGFB1 IL1B IL10 CXCL8
49
IL12-mediated signaling events 1
Show member pathways
 12.09 IL4 IL1B IL18 FASLG
50
TNF signaling pathway 36
12.09 TNF IL1B FAS CCL2
Sources

GO Terms for Silicosis

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Cellular components related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 TNFRSF6B TNF TGFB1 SCGB1A1 NLRP3 IL4
2 extracellular space GO:0005615 9.53 TNFRSF6B TNF TGFB1 SCGB1A1 IL4 IL1RN
3 NLRP3 inflammasome complex GO:0072559 9.16 NLRP3 CASP1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.22 TGFB1 SCGB1A1 NLRP3 IL4 IL1RN IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TNF TGFB1 NLRP3 IL4 IL1B IL1A
3 positive regulation of apoptotic process GO:0043065 10.12 TNF TGFB1 HMOX1 FASLG FAS
4 positive regulation of gene expression GO:0010628 10.12 TNF TGFB1 IL4 IL1B IL1A IL18
5 negative regulation of cell proliferation GO:0008285 10.11 TGFB1 IL1B IL1A IL10 HMOX1 CXCL8
6 apoptotic process GO:0006915 10.09 TNFRSF6B NLRP3 IL1B IL1A IL17A HMOX1
7 MAPK cascade GO:0000165 10.06 TNF TGFB1 IL1B IL18 CCL2
8 angiogenesis GO:0001525 10.05 IL18 HMOX1 CXCL8 CCL2
9 cell-cell signaling GO:0007267 10.04 IL1B IL18 IL17A FASLG
10 positive regulation of protein phosphorylation GO:0001934 10.03 TNF TGFB1 IL1B FAS
11 response to lipopolysaccharide GO:0032496 10.02 SCGB1A1 IL1B IL10 FASLG
12 positive regulation of angiogenesis GO:0045766 10 IL1B IL1A HMOX1 CXCL8
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TGFB1 NLRP3 IL1B IL18
14 response to organic substance GO:0010033 9.93 TNF TGFB1 SCGB1A1 IL10
15 positive regulation of JNK cascade GO:0046330 9.93 TNF IL1RN IL1B IL1A
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL4 IL18
17 regulation of inflammatory response GO:0050727 9.92 TNF SCGB1A1 NLRP3 CASP1
18 cellular response to mechanical stimulus GO:0071260 9.92 TGFB1 IL1B FAS CASP1
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF IL1B IL18
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF IL18 HMOX1
21 response to glucocorticoid GO:0051384 9.91 TNF SCGB1A1 IL1RN IL10
22 cellular response to lipopolysaccharide GO:0071222 9.91 TNF NLRP3 IL1RN IL1B IL1A IL10
23 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.9 TNF NLRP3 CASP1
24 apoptotic signaling pathway GO:0097190 9.9 TNF FASLG FAS CASP1
25 inflammatory response GO:0006954 9.9 TNF TGFB1 NLRP3 IL1RN IL1B IL1A
26 positive regulation of interleukin-6 production GO:0032755 9.89 TNF IL1RN IL1B IL1A
27 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.89 TNF NLRP3 FASLG FAS CASP1
28 positive regulation of cell division GO:0051781 9.88 TGFB1 IL1B IL1A
29 negative regulation of T cell proliferation GO:0042130 9.88 TGFB1 SCGB1A1 IL10
30 neutrophil chemotaxis GO:0030593 9.88 IL1RN IL1B IL1A CXCL8 CCL2
31 positive regulation of interferon-gamma production GO:0032729 9.87 TNF IL1B IL18
32 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 TNF IL1B IL1A
33 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 TNF IL1RN IL1B IL1A HMOX1 FASLG
34 negative regulation of mitotic cell cycle GO:0045930 9.86 TNF TGFB1 IL10
35 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.86 HMOX1 FASLG FAS
36 positive regulation of interleukin-6 secretion GO:2000778 9.86 TNF IL1B IL17A
37 liver regeneration GO:0097421 9.85 TGFB1 IL10 HMOX1
38 extrinsic apoptotic signaling pathway GO:0097191 9.85 TNF TGFB1 FASLG FAS
39 cellular response to organic cyclic compound GO:0071407 9.85 TNF TGFB1 IL1B IL18 CCL2
40 positive regulation of cytokine secretion GO:0050715 9.84 TNF IL1A IL10
41 positive regulation of vascular endothelial growth factor production GO:0010575 9.84 TGFB1 IL1B IL1A
42 protein kinase B signaling GO:0043491 9.84 TNF TGFB1 IL1B CCL2
43 negative regulation of myoblast differentiation GO:0045662 9.82 TNF TGFB1 IL18
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
45 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TGFB1 IL1B IL18 CCL2
46 positive regulation of neuroinflammatory response GO:0150078 9.76 TNF IL1B IL18
47 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.75 IL1RN IL10
48 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.75 IL1B IL18
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IL4 IL10
50 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TNFRSF6B TNF TGFB1 SCGB1A1 NLRP3 IL4
2 cytokine activity GO:0005125 9.4 TNF TGFB1 IL4 IL1RN IL1B IL1A
3 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Silicosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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