MCID: SLC006
MIFTS: 56

Silicosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

MalaCards integrated aliases for Silicosis:

Name: Silicosis 38 12 76 53 55 44 15 73
Silicotuberculosis 12 73
Chronic Silicosis 53 73
Acute Silicosis 53 73
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 53
Silica Pneumoconiosis 12
Accelerated Silicosis 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10325
ICD10 33 J62 J62.8
ICD9CM 35 502
MeSH 44 D012829
NCIt 50 C3369

Summaries for Silicosis

NIH Rare Diseases : 53 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing.  Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months.  People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to beryllium disease and anthracosis. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 76 Silicosis (also known as miner\'s phthisis, grinder\'s asthma, potter\'s rot and other... more...

Related Diseases for Silicosis

Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 beryllium disease 32.4 TGFB1 TNF
2 anthracosis 32.0 CCL2 TNF
3 bagassosis 30.8 CXCL8 IL1B
4 laryngitis 30.2 IL1B TGFB1 TNF
5 mycobacterium kansasii 30.0 CXCL8 NLRP3
6 granulomatous dermatitis 30.0 ACE TNF
7 autoimmune disease 29.5 DSG1 FAS IL1B IL1RN TNF
8 connective tissue disease 29.3 ACE IL1A SFTPD TNF
9 osteoporosis 29.1 IL1A IL1B IL1RN TGFB1 TNF
10 systemic scleroderma 29.1 ACE SFTPD TGFB1
11 pulmonary fibrosis 29.0 CCL2 IL1B SFTPD TGFB1
12 interstitial lung disease 29.0 CCL2 CXCL8 IL1A IL1B SFTPD TGFB1
13 peritonitis 28.9 CCL2 CXCL8 IL1B TNF
14 arthritis 28.1 CCL2 CXCL8 IL1A IL1B IL1RN TNF
15 lung disease 28.0 CCL2 CXCL8 IL1B SFTPD TGFB1 TNF
16 iga glomerulonephritis 27.9 ACE CCL2 SCGB1A1 TGFB1
17 pneumonia 27.8 CCL2 CXCL8 IL1B SCGB1A1 SFTPD TNF
18 pulmonary disease, chronic obstructive 27.4 CCL2 CXCL8 SCGB1A1 SFTPD TGFB1 TNF
19 pneumoconiosis 26.9 CCL2 CXCL8 FAS FASLG IL1A IL1B
20 pulmonary fibrosis, idiopathic 25.5 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
21 asthma 25.2 CCL2 CXCL8 FAS IL1A IL1B IL1RN
22 systemic onset juvenile idiopathic arthritis 10.9 IL1B TNF
23 staphylococcal toxic shock syndrome 10.9 IL1B TNF
24 autoimmune myocarditis 10.8 IL1B TNF
25 chronic follicular conjunctivitis 10.8 IL1A IL1B
26 type ii mixed cryoglobulinemia 10.8 FAS FASLG
27 recurrent corneal erosion 10.8 CXCL8 IL1B
28 lymphocytic gastritis 10.8 FAS FASLG
29 tungiasis 10.7 CXCL8 TNF
30 skin conditions 10.7 IL1A TNF
31 streptococcal toxic-shock syndrome 10.7 CXCL8 TNF
32 kashin-beck disease 10.7 FAS IL1B TNF
33 epstein-barr virus-associated gastric carcinoma 10.7 FAS FASLG TNF
34 cerebral artery occlusion 10.7 IL1B IL1RN TNF
35 osteosclerotic myeloma 10.7 IL1B IL1RN TNF
36 joint disorders 10.7 IL1B IL1RN TNF
37 central nervous system tuberculosis 10.7 FAS FASLG IL1B
38 irritant dermatitis 10.7 IL1A IL1B TNF
39 adult-onset still's disease 10.7 IL1B IL1RN TNF
40 burn scar 10.6 FAS TGFB1
41 pouchitis 10.6 CXCL8 IL1RN
42 haemophilus influenzae 10.6 CXCL8 IL1B TNF
43 crohn's colitis 10.6 CXCL8 IL1B TNF
44 dental pulp disease 10.6 CXCL8 IL1B TNF
45 middle ear disease 10.6 CXCL8 IL1B TNF
46 keratoconjunctivitis sicca 10.6 IL1A IL1B TNF
47 viral hepatitis 10.6 FAS FASLG TNF
48 burns 10.6 IL1B TNF
49 perinatal necrotizing enterocolitis 10.6 CXCL8 IL1B TNF
50 uterine anomalies 10.6 CXCL8 IL1B TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis

Symptoms & Phenotypes for Silicosis

GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 TNFRSF6B CXCL8 FAS IL1A IL1B NLRP3
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 CXCL8 TNFRSF6B FAS FASLG IL1A IL1B

MGI Mouse Phenotypes related to Silicosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.16 SCGB1A1 SFTPD TGFB1 TNF NLRP3 DSG1
2 immune system MP:0005387 10.15 SFTPD TGFB1 TNF SCGB1A1 CCL2 IL1B
3 homeostasis/metabolism MP:0005376 10.14 SCGB1A1 SFTPD TGFB1 TNF IL1A IL1B
4 hematopoietic system MP:0005397 10.13 SFTPD TGFB1 TNF IL1A IL1B FAS
5 cardiovascular system MP:0005385 10.08 TGFB1 TNF ACE IL1A IL1B FAS
6 integument MP:0010771 9.97 TGFB1 TNF IL1A DSG1 IL1B FAS
7 neoplasm MP:0002006 9.76 SCGB1A1 TGFB1 TNF IL1B FAS FASLG
8 liver/biliary system MP:0005370 9.73 TGFB1 TNF NLRP3 ACE FAS FASLG
9 renal/urinary system MP:0005367 9.43 SCGB1A1 TGFB1 NLRP3 ACE FAS FASLG
10 skeleton MP:0005390 9.23 TGFB1 TNF NLRP3 DSG1 IL1B FAS

Drugs & Therapeutics for Silicosis

Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
3
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Anti-Infective Agents Phase 3
7 Antimetabolites Phase 3
8 Antitubercular Agents Phase 3
9 Cytochrome P-450 CYP3A Inducers Phase 3
10 Hypolipidemic Agents Phase 3
11 Lipid Regulating Agents Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13 Mitogens Phase 1, Phase 2
14 Respiratory System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
2 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
4 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
5 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
6 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
7 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
8 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
9 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

Anatomical Context for Silicosis

MalaCards organs/tissues related to Silicosis:

41
Lung, Bone, Lymph Node, Bone Marrow, Testes, Neutrophil, T Cells

Publications for Silicosis

Articles related to Silicosis:

(show top 50) (show all 697)
# Title Authors Year
1
Lung Cancer Mortality in Tuscany from 1971 to 2010 and Its Connections with Silicosis: A Space-Cohort Analysis Based on Shared Models. ( 29796059 )
2018
2
Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis. ( 29856822 )
2018
3
Clinical features of secondary spontaneous pneumothorax complicated with silicosis. ( 29548652 )
2018
4
The Role of Fibrocyte in the Pathogenesis of Silicosis. ( 29773095 )
2018
5
Erasmus syndrome: systemic sclerosis and silicosis co-occurrence. ( 29667340 )
2018
6
Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats. ( 29673394 )
2018
7
Response to: 'Artificial stone-associated silicosis in the UK' by Barber <i>et al</i>. ( 29574403 )
2018
8
Pulmonary tuberculosis in a male with silicosis. ( 29960278 )
2018
9
Inflammatory and oxidative stress parameters as potential early biomarkers for silicosis. ( 29860036 )
2018
10
Pleuroparenchymal Fibroelastosis and Silicosis: An Unexpected Association. ( 29580565 )
2018
11
Erasmus Syndrome: Association of Silicosis and Systemic Sclerosis. ( 29854640 )
2018
12
Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse. ( 29755467 )
2018
13
Artificial stone-associated silicosis in the UK. ( 29444932 )
2018
14
Percutaneous treatment for silicosis-induced pulmonary artery stenosis: A case report and review of the literature. ( 29480834 )
2018
15
Proximal limb weakness and amyotrophy in a man with silicosis. ( 29364397 )
2018
16
Silicosis decreases bone mineral density in rats. ( 29680408 )
2018
17
Comparison of digital and film chest radiography for detection and medical surveillance of silicosis in a setting with a high burden of tuberculosis. ( 29210092 )
2018
18
Silicosis in Turkey: Is it an Endless Nightmare or is There Still Hope? ( 29755813 )
2018
19
Archival sources on asbestos and silicosis in Southern Africa and Australia. ( 29348448 )
2018
20
Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis. ( 29843724 )
2018
21
The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population. ( 29621588 )
2018
22
EBUS-TBNA is Sufficient for Successful Diagnosis of Silicosis with Mediastinal Lymphadenopathy. ( 29845341 )
2018
23
Comparative RNA-Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis model. ( 29341224 )
2018
24
IL-10-Producing CD1d(hi)CD5(+) Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients. ( 28243231 )
2017
25
What is expected in lung function after lung transplantation due to end-stage pulmonary silicosis? ( 28871617 )
2017
26
Perceived Health Related Quality of Life Outcomes with Silicosis Patients. ( 29026799 )
2017
27
Complicated silicosis resulting from occupational exposure to engineered stone products. ( 28490299 )
2017
28
A reliability and readability analysis of silicosis-related Italian websites: implications for occupational health. ( 28660869 )
2017
29
Silicosis prevalence and risk factors in semi-precious stone mining in Brazil. ( 28514023 )
2017
30
Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice. ( 29126438 )
2017
31
Imipramine blocks acute silicosis in a mouse model. ( 28893276 )
2017
32
Influence of quartz exposure on lung cancer types in cases of lymph node-only silicosis and lung silicosis in German uranium miners. ( 28443719 )
2017
33
Death in the New Town: Edinburgh's hidden story of stonemasons' silicosis. ( 29537413 )
2017
34
Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis. ( 28481151 )
2017
35
Plastic bronchitis in a patient with silicosis. ( 28365186 )
2017
36
Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis. ( 28360865 )
2017
37
Serum concentrations of Krebs von den Lungen-6, surfactant protein D, and matrix metalloproteinase-2 as diagnostic biomarkers in patients with asbestosis and silicosis: a case-control study. ( 29149883 )
2017
38
Silicosis, then microscopic polyangiitis-antineutrophil cytoplasmic antibodies-associated vasculitis may be work-related disease in patients with silicosis. ( 29264045 )
2017
39
Artificial stone-associated silicosis: a rapidly emerging occupational lung disease. ( 28882991 )
2017
40
Rapid Radiologic Progression of Silicosis. ( 28339287 )
2017
41
Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis. ( 28222740 )
2017
42
Lichen Planus in Silicosis Patient with Unusually High Antinuclear Antibody Titer. ( 28979026 )
2017
43
BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. ( 28277537 )
2017
44
Erasmus Syndrome: Silicosis and Systemic Sclerosis. ( 29540971 )
2017
45
Bullous pemphigoid associated with silicosis. ( 28622458 )
2017
46
Experimental silicosis does not aggravate collagen-induced arthritis in mice. ( 28285600 )
2017
47
Silicosis mortality in Italy: temporal trends 1990-2012 and spatial patterns 2000-2012. ( 29297856 )
2017
48
Infodemiological data concerning silicosis in the USA in the period 2004-2010 correlating with real-world statistical data. ( 28054008 )
2017
49
Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis. ( 28916165 )
2017
50
Surveillance for Silicosis Deaths Among Persons Aged 15-44 Years - United States, 1999-2015. ( 28727677 )
2017

Variations for Silicosis

Expression for Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for Silicosis

Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CCL2 CXCL8 DSG1 FASLG IL1A IL1B
2
Show member pathways
13.84 CCL2 CXCL8 FAS FASLG IL1A IL1B
3
Show member pathways
13.64 CCL2 CXCL8 FAS FASLG IL1A IL1B
4
Show member pathways
13.54 CXCL8 FAS FASLG IL1A IL1B TGFB1
5
Show member pathways
13.39 CCL2 CXCL8 FAS FASLG IL1A IL1B
6
Show member pathways
13.31 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
7
Show member pathways
13.28 CCL2 CXCL8 FAS FASLG IL1A IL1B
8
Show member pathways
12.89 CCL2 FAS FASLG TNF TNFRSF6B
9
Show member pathways
12.87 CXCL8 FAS FASLG IL1A IL1B TGFB1
10 12.77 FAS FASLG IL1A IL1B TGFB1 TNF
11
Show member pathways
12.72 CCL2 CXCL8 FAS FASLG IL1A IL1B
12
Show member pathways
12.71 ACE CCL2 CXCL8 FAS FASLG IL1B
13
Show member pathways
12.67 FAS FASLG IL1A IL1B TNF
14
Show member pathways
12.63 CXCL8 IL1A IL1B TNF
15
Show member pathways
12.58 CXCL8 FAS FASLG TGFB1 TNF
16 12.56 CCL2 FAS FASLG IL1B IL1RN TNF
17
Show member pathways
12.52 FASLG IL1A IL1B TNF
18
Show member pathways
12.45 IL1A IL1B TGFB1 TNF
19
Show member pathways
12.44 FAS IL1A IL1B TGFB1 TNF
20
Show member pathways
12.35 CCL2 CXCL8 IL1B TNF
21
Show member pathways
12.32 CCL2 IL1A IL1B IL1RN
22 12.31 FAS FASLG TGFB1 TNF
23
Show member pathways
12.28 IL1A IL1B TGFB1 TNF
24
Show member pathways
12.28 CXCL8 IL1A IL1B TNF
25 12.27 FAS FASLG TNF TNFRSF6B
26 12.25 IL1A IL1B TGFB1 TNF
27
Show member pathways
12.23 FAS FASLG IL1A TNF
28
Show member pathways
12.23 CXCL8 IL1A IL1B IL1RN TNF
29
Show member pathways
12.21 FAS FASLG IL1A IL1B NLRP3 TNF
30 12.19 CXCL8 IL1A IL1B IL1RN TNF
31
Show member pathways
12.17 CXCL8 FAS FASLG IL1B SFTPD TNF
32 12.12 CCL2 IL1A IL1B TNF
33
Show member pathways
12.09 CCL2 CXCL8 IL1A IL1B TGFB1
34 12.06 IL1A IL1B TGFB1 TNF
35 12.04 FAS TGFB1 TNF
36 11.99 CCL2 FAS IL1B TNF
37 11.96 CXCL8 IL1A IL1B TGFB1
38 11.92 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
39 11.91 CXCL8 IL1B TGFB1 TNF
40 11.9 IL1A IL1B TNF
41 11.88 CXCL8 IL1B TNF
42 11.84 CXCL8 IL1A IL1B
43 11.79 CXCL8 IL1A IL1B NLRP3 TNF
44 11.79 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
45
Show member pathways
11.78 CXCL8 FASLG TNF
46 11.77 IL1B TGFB1 TNF
47
Show member pathways
11.7 CXCL8 IL1A IL1B TNF
48 11.69 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
49 11.65 CCL2 CXCL8 IL1B TGFB1 TNF
50 11.62 CXCL8 IL1B TNF

GO Terms for Silicosis

Cellular components related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE CCL2 CXCL8 FASLG IL1A IL1B
2 lysosome GO:0005764 9.56 ACE FASLG IL1B SFTPD
3 extracellular region GO:0005576 9.47 ACE CCL2 CXCL8 FAS FASLG IL1A
4 secretory granule GO:0030141 9.33 IL1B SCGB1A1 TGFB1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 CCL2 IL1B TGFB1 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.99 CCL2 IL1A TGFB1 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.94 FASLG IL1A IL1B TNF
4 positive regulation of protein phosphorylation GO:0001934 9.93 FAS IL1B TGFB1 TNF
5 regulation of cell proliferation GO:0042127 9.93 CXCL8 FAS TGFB1 TNF TNFRSF6B
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B NLRP3 TGFB1 TNF
7 response to organic substance GO:0010033 9.89 SCGB1A1 TGFB1 TNF
8 interleukin-1-mediated signaling pathway GO:0070498 9.88 IL1A IL1B IL1RN
9 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 CXCL8 NLRP3 TNF
10 regulation of inflammatory response GO:0050727 9.87 NLRP3 SCGB1A1 TNF
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.87 FAS FASLG TNF TNFRSF6B
12 cellular response to mechanical stimulus GO:0071260 9.86 FAS IL1B TGFB1
13 regulation of signaling receptor activity GO:0010469 9.86 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
14 positive regulation of JNK cascade GO:0046330 9.85 IL1A IL1B TNF
15 neutrophil chemotaxis GO:0030593 9.85 CCL2 CXCL8 IL1B
16 response to glucocorticoid GO:0051384 9.84 IL1RN SCGB1A1 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.83 IL1A IL1B TNF
18 positive regulation of cell division GO:0051781 9.83 IL1A IL1B TGFB1
19 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.83 FAS FASLG NLRP3 TNF
20 apoptotic signaling pathway GO:0097190 9.81 FAS FASLG TNF TNFRSF6B
21 negative regulation of T cell proliferation GO:0042130 9.8 SCGB1A1 SFTPD TGFB1
22 cellular response to organic cyclic compound GO:0071407 9.8 CCL2 IL1B TGFB1 TNF
23 response to lipopolysaccharide GO:0032496 9.8 CXCL8 FAS FASLG IL1B SCGB1A1 TNFRSF6B
24 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.78 IL1A IL1B TNF
25 protein kinase B signaling GO:0043491 9.78 CCL2 IL1B TGFB1 TNF
26 positive regulation of phagocytosis GO:0050766 9.77 IL1B SFTPD TNF
27 extrinsic apoptotic signaling pathway GO:0097191 9.76 FAS FASLG TGFB1 TNF
28 cytokine-mediated signaling pathway GO:0019221 9.76 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
29 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.75 IL1B NLRP3 TNF
30 positive regulation of histone acetylation GO:0035066 9.72 IL1B TGFB1
31 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
32 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.72 FAS FASLG
33 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
34 positive regulation of vascular endothelial growth factor production GO:0010575 9.72 IL1A IL1B TGFB1
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
36 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.71 FAS FASLG
37 macrophage chemotaxis GO:0048246 9.71 CCL2 SFTPD
38 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1A IL1B
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
40 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
41 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
42 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
43 ectopic germ cell programmed cell death GO:0035234 9.67 IL1A IL1B
44 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
45 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TGFB1 TNF
46 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
47 interleukin-1 beta production GO:0032611 9.65 IL1B NLRP3
48 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.65 IL1A TGFB1
49 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 protein binding GO:0005515 10 CCL2 CXCL8 DSG1 FAS FASLG IL1A

Sources for Silicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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