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MCID: SLC006
MIFTS: 56

Silicosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Silicosis

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MalaCards integrated aliases for Silicosis:

Name: Silicosis 12 74 20 54 44 15 17 71
Silicotuberculosis 12 71
Chronic Silicosis 20 71
Acute Silicosis 20 71
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 20
Silica Pneumoconiosis 12
Accelerated Silicosis 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10325
ICD9CM 34 502
MeSH 44 D012829
NCIt 50 C3369
SNOMED-CT 67 155590008
ICD10 32 J62.8
UMLS 71 C0037116 C0037118 C0340190 more
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Summaries for Silicosis

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GARD : 20 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to anthracosis and beryllium disease. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Nintedanib and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and lymph node, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 74 Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. It is... more...

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Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 730)
# Related Disease Score Top Affiliating Genes
1 anthracosis 32.0 TNF TGFB1 SCGB1A1 IL1B CXCL8 CCL2
2 beryllium disease 32.0 TNF TGFB1
3 bronchitis 31.1 TNF IL4 IL1B IL10 CXCL8
4 pulmonary fibrosis 31.0 TGFB1 SFTPD IL1RN IL1B CXCL8 CCL2
5 glomerulonephritis 30.7 TGFB1 SCGB1A1 IL1B CCL2
6 pulmonary tuberculosis 30.6 TNF IL4 IL18 IL10 CCL2
7 pulmonary emphysema 30.6 SFTPD IL18 HMOX1 CXCL8
8 pericarditis 30.5 TNF IL1B CXCL8
9 systemic scleroderma 30.5 TNF TGFB1 SFTPD IL4 IL17A IL10
10 bagassosis 30.4 TNF IL1B CXCL8
11 mycobacterium tuberculosis 1 30.3 TNF IL4 IL18 IL17A IL10
12 pulmonary alveolar proteinosis 30.3 TNF SFTPD IL10 CXCL8 CCL2
13 pemphigoid 30.3 TNF TGFB1 IL4 IL1B
14 chronic beryllium disease 30.3 TNF TGFB1
15 mycobacterium kansasii 30.3 NLRP3 CXCL8
16 pemphigus 30.3 TNF IL4 IL10 DSG1
17 autoimmune lymphoproliferative syndrome 30.2 TNF IL10 FASLG FAS
18 allergic disease 30.2 TNF IL4 IL1B IL18
19 pleural disease 30.2 TNF IL1B CXCL8
20 iritis 30.2 TNF IL17A IL10
21 sarcoidosis 1 30.2 TNF SFTPD SCGB1A1 IL1RN IL1B IL1A
22 erythema nodosum 30.2 TNF IL1B IL1A IL10 CXCL8
23 pulmonary sarcoidosis 30.2 TNF SFTPD IL18 CCL2
24 bullous pemphigoid 30.2 TNF IL4 DSG1 CXCL8
25 purpura 30.1 TNF IL4 IL1B IL10
26 cryptogenic organizing pneumonia 30.1 TNF SFTPD CXCL8
27 interstitial lung disease 30.0 TNF TGFB1 SFTPD IL4 IL1B IL1A
28 pharyngitis 29.9 TNF NLRP3 IL1B CXCL8
29 respiratory failure 29.9 TNF SFTPD SCGB1A1 IL1RN IL1B IL1A
30 pleurisy 29.9 TNF TGFB1 IL1RN CXCL8 CCL2
31 paracoccidioidomycosis 29.9 TNF IL4 IL10 CXCL8
32 lymphopenia 29.9 IL4 IL10 FASLG FAS
33 dysentery 29.9 TNF IL1B IL1A IL10 CXCL8
34 peptic ulcer disease 29.8 TNF IL1RN IL1B IL10 CXCL8
35 mycetoma 29.8 IL17A IL10 CXCL8
36 bronchopneumonia 29.8 TNF IL1B IL17A IL10 CXCL8
37 pulmonary hypertension 29.8 TNF TGFB1 IL1B IL1A IL10 HMOX1
38 endocarditis 29.8 TNF IL1A IL17A IL10 CXCL8
39 idiopathic interstitial pneumonia 29.8 TGFB1 SFTPD IL4 CXCL8 CCL2
40 spondylitis 29.8 TNF IL1B IL17A IL10
41 end stage renal disease 29.7 TNF TGFB1 IL1RN IL1B IL10 CCL2
42 spondyloarthropathy 1 29.7 TNF IL1RN IL17A
43 extrapulmonary tuberculosis 29.7 IL1RN IL1B IL1A IL10 CCL2
44 cryptococcosis 29.7 TNF IL4 IL17A IL10
45 crescentic glomerulonephritis 29.7 TNFRSF6B SCGB1A1 CCL2
46 pneumoconiosis 29.7 TNF TGFB1 SCGB1A1 NLRP3 IL4 IL1RN
47 toxic shock syndrome 29.6 TNF IL4 IL1RN IL1B IL10 CXCL8
48 aspergillosis 29.6 TNF SFTPD IL4 IL1B IL1A IL18
49 pulmonary edema 29.6 TNF SCGB1A1 IL1B IL10 HMOX1 CXCL8
50 synovitis 29.6 TNF IL1RN IL1B IL1A IL18 CXCL8

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis
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Symptoms & Phenotypes for Silicosis

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GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 10 CASP1 HMOX1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 10 CASP1 FAS FASLG HMOX1 IL10 IL18
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 10 IL1A
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.68 CXCL8 FAS IL10 IL17A IL18 IL1A
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.68 CASP1 CXCL8 FAS HMOX1 IL10 IL17A
6 Reduced mammosphere formation GR00396-S 9.5 CASP1 CCL2 CXCL8 FAS FASLG IL17A

MGI Mouse Phenotypes related to Silicosis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 CASP1 DSG1 FAS FASLG HMOX1 IL10
2 hematopoietic system MP:0005397 10.4 CASP1 FAS FASLG HMOX1 IL10 IL17A
3 growth/size/body region MP:0005378 10.39 CASP1 DSG1 FAS HMOX1 IL10 IL17A
4 immune system MP:0005387 10.39 CASP1 CCL2 FAS FASLG HMOX1 IL10
5 cellular MP:0005384 10.34 CASP1 FAS FASLG HMOX1 IL10 IL18
6 cardiovascular system MP:0005385 10.31 CASP1 FAS FASLG HMOX1 IL10 IL18
7 integument MP:0010771 10.28 CASP1 DSG1 FAS FASLG IL10 IL17A
8 digestive/alimentary MP:0005381 10.24 CASP1 FAS FASLG IL10 IL17A IL18
9 mortality/aging MP:0010768 10.24 CASP1 FAS FASLG HMOX1 IL10 IL17A
10 endocrine/exocrine gland MP:0005379 10.22 CASP1 FAS FASLG HMOX1 IL10 IL17A
11 craniofacial MP:0005382 10.15 FAS HMOX1 IL10 IL17A IL1B IL4
12 liver/biliary system MP:0005370 10.01 FAS FASLG HMOX1 IL10 IL4 NLRP3
13 neoplasm MP:0002006 9.97 CASP1 FAS FASLG IL10 IL1A IL1B
14 renal/urinary system MP:0005367 9.91 CASP1 FAS FASLG HMOX1 IL17A IL4
15 reproductive system MP:0005389 9.85 CASP1 FAS FASLG HMOX1 IL10 IL1RN
16 respiratory system MP:0005388 9.65 FAS FASLG HMOX1 IL10 IL17A IL4
17 skeleton MP:0005390 9.36 DSG1 FAS FASLG IL10 IL17A IL1B
Sources

Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nintedanib Approved Phase 2 656247-17-5 56843413
2 Mitogens Phase 1, Phase 2
3
Cocaine Approved, Illicit 50-36-2 5760 446220
4
Rifapentine Approved, Investigational 61379-65-5 6323497
5
Isoniazid Approved, Investigational 54-85-3 3767
6
Rifampicin Approved 13292-46-1 5458213 5381226
7 Respiratory System Agents
8 Antibiotics, Antitubercular
9 Antitubercular Agents
10 Anti-Infective Agents
11 Anti-Bacterial Agents
12 Lipid Regulating Agents
13 Antimetabolites
14 Hypolipidemic Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Effectiveness and Tolerability of Weekly Rifapentine/Isoniazid for 3 Months for Tuberculosis Preventive Treatment: A Randomized Controlled Study in China Completed NCT02430259 Phase 3 Weekly INH / RRT given by DOT
2 Phase 1 Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
4 Phase-1 Study of Autologous Bone Marrow Cells Intrabronchial Instillation for Patients Silicosis Completed NCT01239862 Phase 1
5 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
6 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
7 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
8 The Use of Forced Oscillation Technique in the Analysis of Respiratory System in Never-smoking Patients With Silicosis:Pathophysiological Study and Evaluation of Diagnostic Accuracy Completed NCT01725971
9 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
10 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Recruiting NCT04205708
11 Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB) Recruiting NCT03900858 Isoniazidï¼›Rifapentine

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

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Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

40
Lung, Bone Marrow, Lymph Node, Bone, Neutrophil, Heart, Skin
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Publications for Silicosis

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Articles related to Silicosis:

(show top 50) (show all 5888)
# Title Authors PMID Year
1
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. 61 54
18666137 2008
2
[Polymorphisms of FAS and FASL genes and susceptibility of silicosis]. 54 61
18302883 2008
3
Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis. 54 61
17693780 2007
4
Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages. 61 54
17393098 2007
5
[Changes of Clara cell protein and surfactant protein-D in serum of patients with silicosis]. 61 54
17374182 2007
6
Apoptosis and extracellular matrix remodelling in human silicosis. 54 61
16918975 2006
7
Alterations of Fas and Fas-related molecules in patients with silicosis. 61 54
16636300 2006
8
Detection, epitope-mapping and function of anti-Fas autoantibody in patients with silicosis. 61 54
16108814 2005
9
[Sudy on the activation of early growth response factor-1 by silica dioxide and its signal pathway]. 61 54
16181552 2005
10
[Dysregulation of Fas and related molecules in silicosis patients]. 61 54
15773295 2005
11
[The role of Egr-1 and NF-kappaB in the pathogenesis of silicosis: an in-vitro study]. 61 54
15363325 2004
12
The central role of Fas-ligand cell signaling in inflammatory lung diseases. 61 54
15491504 2004
13
[Expression of early growth response gene-1 in macrophages stimulated by silicon dioxide]. 61 54
14761604 2003
14
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. 61 54
14514471 2003
15
Significance of genetic information in risk assessment and individual classification using silicosis as a case model. 54 61
12176706 2002
16
Polymorphisms of the IL-1 gene complex in coal miners with silicosis. 54 61
11241561 2001
17
Antidesmoglein autoantibodies in silicosis patients with no bullous diseases. 54 61
11244222 2001
18
Detection of alternatively spliced variant messages of Fas gene and mutational screening of Fas and Fas ligand coding regions in peripheral blood mononuclear cells derived from silicosis patients. 54 61
10841950 2000
19
Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients. 61 54
10632670 2000
20
Serum levels of soluble Fas ligand in patients with silicosis. 54 61
10594565 1999
21
Soluble Fas mRNA is dominantly expressed in cases with silicosis. 61 54
9741350 1998
22
Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumours. 61 54
9367417 1997
23
Mini-review: Silico-tuberculosis. 61
33598569 2021
24
Long noncoding RNA-SNHG20 promotes silica-induced pulmonary fibrosis by miR-490-3p/TGFBR1 axis. 61
33482250 2021
25
Astragaloside IV alleviates silica‑induced pulmonary fibrosis via inactivation of the TGF‑β1/Smad2/3 signaling pathway. 61
33448318 2021
26
Snail-mediated partial epithelial mesenchymal transition augments the differentiation of local lung myofibroblast. 61
33172668 2021
27
Mortality from silicosis in Brazil: Temporal trends in the period 1980-2017. 61
33410169 2021
28
COVID-19: a new burden of respiratory disease among South African miners? 61
33417344 2021
29
Atractylenolide III alleviates the apoptosis through inhibition of autophagy by the mTOR-dependent pathway in alveolar macrophages of human silicosis. 61
33078341 2021
30
Lung transplantation for silicosis and recovery: an Australian case study. 61
33565932 2021
31
The role of macrophage-derived TGF-β1 on SiO2-induced pulmonary fibrosis: A review. 61
33588701 2021
32
SiO2 stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway. 61
33559204 2021
33
[Inhibition of Wnt/β-catenin signal and NOX4 impairs repair of silica-induced lung epithelial cell injury]. 61
33504419 2021
34
Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition. 61
33352442 2021
35
The UFSP2/UFMylation Pathway Is Involved in Silica-Induced Pulmonary Injury. 61
33600261 2021
36
ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy. 61
33545378 2021
37
Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica-induced epithelial-mesenchymal transition in human bronchial epithelial cells. 61
33546743 2021
38
The association of silicosis severity with pectoralis major muscle and subcutaneous fat volumes and the pulmonary artery/aorta ratio evaluated by CT. 61
32209510 2021
39
Macrophage Autophagy and Silicosis: Current Perspective and Latest Insights. 61
33466366 2021
40
Investigation of MicroRNA and transcription factor mediated regulatory network for silicosis using systems biology approach. 61
33446673 2021
41
Silicosis. 61
33174526 2021
42
Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway. 61
33398741 2021
43
Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2. 61
33500731 2021
44
Evaluation of lung densitometric and volumetric changes in silicosis patients using three-dimensional software for multidetector CT and the relationship with profusion scores. 61
33509607 2021
45
Silicosis in a paint-production worker: Study of a lung histological specimen with scanning electron microscopy-Energy dispersive X-ray spectrometer. 61
33489134 2021
46
[Research progress of silica-associated autoimmune diseases]. 61
33535350 2021
47
Systematic review and meta-analysis of epidemiological studies on the association of occupational exposure to free crystalline silica and systemic lupus erythematosus. 61
33140090 2021
48
Costs of asbestosis and silicosis hospitalization in Italy (2001-2018) : Costs of asbestosis and silicosis hospitalization. 61
33404732 2021
49
Alteration of thiol disulfide homeostasis and ischemia-modified albumin levels as indicators of oxidative status in patients with silicosis. 61
33305688 2021
50
Sex-Related Differences in the Risk of Silicosis Among Chinese Pottery Workers: A Cohort Study. 61
33122539 2021
Sources

Variations for Silicosis

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Expression for Silicosis

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Search GEO for disease gene expression data for Silicosis.
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Pathways for Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.11 TNFRSF6B TNF TGFB1 NLRP3 IL4 IL1RN
2
ERK Signaling 63
Show member pathways
 13.95 TNFRSF6B TNF TGFB1 IL4 IL1B IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.75 TNFRSF6B TNF TGFB1 IL4 IL1RN IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.66 TNF TGFB1 IL4 IL1B IL1A IL18
5
Akt Signaling 63
Show member pathways
 13.56 TNF TGFB1 IL4 IL1B IL1A IL18
6
PAK Pathway 63
Show member pathways
 13.39 TNF TGFB1 IL4 IL1B IL1A IL18
7
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 13.36 TNF TGFB1 IL1B IL1A FASLG FAS
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.22 TNF TGFB1 SFTPD IL1B IL10 FASLG
9
Cytokine Signaling in Immune system 65
Show member pathways
 13.14 TNFRSF6B TNF TGFB1 IL4 IL1RN IL1B
10
Human cytomegalovirus infection 36
Show member pathways
 13.03 TNF IL1B FASLG FAS CXCL8 CCL2
11
Allograft rejection 36 1
Show member pathways
 12.99 TNF TGFB1 IL4 IL1B IL1A IL17A
12
Measles 36
Show member pathways
 12.97 TNF NLRP3 IL1B IL1A IL18 FASLG
13
Pathways in cancer 36
12.95 TGFB1 IL4 HMOX1 FASLG FAS CXCL8
14
MAPK signaling pathway 36 1
12.91 TNF TGFB1 IL1B IL1A FASLG FAS
15
Salmonella infection (KEGG) 36
Show member pathways
 12.91 TNF NLRP3 IL1B IL18 FASLG FAS
16
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.88 TNF NLRP3 IL1RN IL1B IL1A IL18
17
Herpes simplex virus 1 infection 36
12.86 TNF IL1B FASLG FAS CCL2
18
T cell receptor signaling pathway 36
Show member pathways
 12.8 TNF TGFB1 IL4 IL1B IL1A IL17A
19
Th17 cell differentiation 36
Show member pathways
 12.79 TNF TGFB1 IL4 IL1B IL1A IL18
20
Apoptosis Modulation and Signaling 1
Show member pathways
 12.78 TNFRSF6B TNF FASLG FAS CASP1
21
4-1BB Pathway 63
Show member pathways
 12.75 TNF IL1B IL1A FASLG FAS
22
Immune response IL-23 signaling pathway 23
Show member pathways
 12.73 TNF IL1B IL18 IL17A IL10 CCL2
23
TRAF Pathway 63
Show member pathways
 12.72 TNF IL1B IL1A FASLG FAS CASP1
24
NF-kappaB Signaling 4
12.58 TNF IL4 IL1RN IL1B IL17A IL10
25
Shigellosis 36
12.56 TNF NLRP3 IL1B IL18 CXCL8 CASP1
26
IL-17 Family Signaling Pathways 64
Show member pathways
 12.5 TNF IL4 IL1B IL17A CXCL8 CCL2
27
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.47 TNF IL18 IL10 CXCL8 CCL2
28
IL-1 signaling pathway 1
Show member pathways
 12.44 IL1RN IL1B IL1A CCL2 CASP1
29
Toxoplasmosis 36
Show member pathways
 12.44 TNF TGFB1 IL4 IL1B IL1A IL10
30
NOD-like receptor signaling pathway 36
12.44 TNF NLRP3 IL1B IL18 CXCL8 CCL2
31
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.43 TNF TGFB1 IL4 IL1B IL1A IL18
32
Tuberculosis 36
12.41 TNF TGFB1 IL1B IL1A IL18 IL10
33
Necroptosis 36
Show member pathways
 12.4 TNF NLRP3 IL1B IL1A FASLG FAS
34
Folate Metabolism 1
Show member pathways
 12.39 TNF IL4 IL1B CCL2
35
Apoptosis and Autophagy 4
12.39 TNFRSF6B TNF FASLG FAS CASP1
36
Proteoglycans in cancer 36
12.37 TNF TGFB1 FASLG FAS
37
Apoptosis and survival Caspase cascade 23
Show member pathways
 12.37 TNF IL1A FASLG FAS CASP1
38
Bacterial infections in CF airways 23
Show member pathways
 12.37 TNF SFTPD IL4 IL1B FASLG FAS
39
C-type lectin receptor signaling pathway 36
Show member pathways
 12.36 TNF NLRP3 IL1B IL10 CASP1
40
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.36 TNF IL1RN IL1B IL1A IL10 CXCL8
41
Fluid shear stress and atherosclerosis 36
12.25 TNF IL1B IL1A HMOX1 CCL2
42
Spinal Cord Injury 1
12.2 TNF TGFB1 IL4 IL1B IL1A CXCL8
43
Yersinia infection 36
12.2 TNF NLRP3 IL1B IL18 IL10 CXCL8
44
Osteoclast differentiation 36
12.16 TNF TGFB1 IL1B IL1A
45
AGE-RAGE signaling pathway in diabetic complications 36
12.14 TNF TGFB1 IL1B IL1A CXCL8 CCL2
46
IL12-mediated signaling events 1
Show member pathways
 12.1 IL4 IL1B IL18 FASLG
47
Amoebiasis 36
12.1 TNF TGFB1 IL1B IL10 CXCL8
48
TNF signaling pathway 36
12.09 TNF IL1B FAS CCL2
49
Senescence and Autophagy in Cancer 1
12.07 TGFB1 IL1B IL1A CXCL8
50
Hematopoietic cell lineage 36
12.04 TNF IL4 IL1B IL1A
Sources

GO Terms for Silicosis

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Cellular components related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 TNFRSF6B TNF TGFB1 SFTPD SCGB1A1 IL4
2 extracellular region GO:0005576 9.58 TNFRSF6B TNF TGFB1 SFTPD SCGB1A1 NLRP3
3 NLRP3 inflammasome complex GO:0072559 9.16 NLRP3 CASP1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 TNF TGFB1 NLRP3 IL4 IL1A IL18
2 signal transduction GO:0007165 10.21 SCGB1A1 NLRP3 IL4 IL1RN IL1B IL18
3 positive regulation of apoptotic process GO:0043065 10.11 TNF TGFB1 HMOX1 FASLG FAS
4 negative regulation of cell proliferation GO:0008285 10.11 TGFB1 IL1B IL1A IL10 HMOX1 CXCL8
5 positive regulation of gene expression GO:0010628 10.09 TNF TGFB1 IL4 IL1B IL1A IL18
6 angiogenesis GO:0001525 10.05 IL18 HMOX1 CXCL8 CCL2
7 MAPK cascade GO:0000165 10.05 TNF TGFB1 IL1B IL18 CCL2
8 cell-cell signaling GO:0007267 10.03 IL1B IL18 IL17A FASLG
9 positive regulation of protein phosphorylation GO:0001934 10.02 TNF TGFB1 IL1B FAS
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.02 TNF HMOX1 FASLG CASP1
11 apoptotic process GO:0006915 10.02 TNFRSF6B NLRP3 IL1B IL1A IL17A HMOX1
12 positive regulation of angiogenesis GO:0045766 10 IL1B IL1A HMOX1 CXCL8
13 response to lipopolysaccharide GO:0032496 9.99 SCGB1A1 IL1B IL10 FASLG CASP1
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.98 TNF TGFB1 NLRP3 IL1B IL18
15 tumor necrosis factor-mediated signaling pathway GO:0033209 9.96 TNFRSF6B TNF FASLG FAS
16 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.93 TNF FASLG FAS CASP1
17 positive regulation of interleukin-6 production GO:0032755 9.93 TNF IL1B IL1A IL17A
18 cellular response to interleukin-1 GO:0071347 9.92 IL17A CXCL8 CCL2
19 response to organic substance GO:0010033 9.92 TNF TGFB1 SCGB1A1 IL10
20 cellular response to mechanical stimulus GO:0071260 9.92 TGFB1 IL1B FAS CASP1
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL4 IL18
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF IL1B IL18
23 apoptotic signaling pathway GO:0097190 9.91 TNF FASLG FAS CASP1
24 positive regulation of interferon-gamma production GO:0032729 9.9 TNF IL1B IL18
25 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL18 HMOX1
26 response to glucocorticoid GO:0051384 9.9 TNF SCGB1A1 IL1RN IL10
27 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.89 TNF NLRP3 CASP1
28 positive regulation of cell division GO:0051781 9.88 TGFB1 IL1B IL1A
29 positive regulation of phagocytosis GO:0050766 9.87 TNF SFTPD IL1B
30 positive regulation of interleukin-1 beta production GO:0032731 9.87 TNF NLRP3 IL17A CASP1
31 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.86 TNF TGFB1 IL10
32 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.86 HMOX1 FASLG FAS
33 negative regulation of mitotic cell cycle GO:0045930 9.86 TNF TGFB1 IL10
34 positive regulation of cytokine production GO:0001819 9.86 TNF IL1A IL10 CASP1
35 cellular response to lipopolysaccharide GO:0071222 9.86 TNF NLRP3 IL1B IL1A IL10 CXCL8
36 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 TNF IL1B IL1A
37 inflammatory response GO:0006954 9.85 TNF TGFB1 NLRP3 IL1RN IL1B IL1A
38 liver regeneration GO:0097421 9.84 TGFB1 IL10 HMOX1
39 extrinsic apoptotic signaling pathway GO:0097191 9.84 TNF TGFB1 FASLG FAS
40 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.83 IL4 IL1A FAS
41 positive regulation of vascular endothelial growth factor production GO:0010575 9.83 TGFB1 IL1B IL1A
42 negative regulation of T cell proliferation GO:0042130 9.83 TGFB1 SFTPD SCGB1A1 IL10
43 negative regulation of myoblast differentiation GO:0045662 9.82 TNF TGFB1 IL18
44 protein kinase B signaling GO:0043491 9.8 TNF TGFB1 IL1B CCL2
45 cellular response to organic cyclic compound GO:0071407 9.8 TNF TGFB1 IL1B IL18 CCL2
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 TNF IL1B IL10
47 positive regulation of neuroinflammatory response GO:0150078 9.75 TNF IL1B IL18
48 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.74 TNF TGFB1
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IL4 IL10
50 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.74 IL1RN IL10

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TNFRSF6B TNF TGFB1 SFTPD SCGB1A1 NLRP3
2 cytokine activity GO:0005125 9.4 TNF TGFB1 IL4 IL1RN IL1B IL1A
3 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Silicosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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