MCID: SLC006
MIFTS: 57

Silicosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

MalaCards integrated aliases for Silicosis:

Name: Silicosis 38 12 76 53 55 44 15 73
Silicotuberculosis 12 73
Chronic Silicosis 53 73
Acute Silicosis 53 73
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 53
Silica Pneumoconiosis 12
Accelerated Silicosis 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10325
ICD10 33 J62 J62.8
ICD9CM 35 502
MeSH 44 D012829
NCIt 50 C3369
SNOMED-CT 68 805002

Summaries for Silicosis

NIH Rare Diseases : 53 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing.  Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months.  People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to anthracosis and interstitial lung disease. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Rifapentine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 76 Silicosis (also known as miner''s phthisis, grinder''s asthma, potter''s rot and other... more...

Related Diseases for Silicosis

Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 anthracosis 32.3 CCL2 TNF
2 interstitial lung disease 30.8 CCL2 CXCL8 IL1A IL1B SFTPD TGFB1
3 bagassosis 30.1 CXCL8 IL1B
4 pulmonary fibrosis 30.0 CCL2 IL1B SFTPD TGFB1
5 viral infectious disease 29.9 CXCL8 IL1B TNF
6 granulomatous dermatitis 29.9 ACE TNF
7 pericarditis 29.9 IL1B IL1RN TNF
8 connective tissue disease 29.8 ACE IL1A SFTPD TNF
9 glomerulonephritis 29.8 CCL2 IL1B TGFB1
10 pneumoconiosis 29.8 CCL2 CXCL8 FAS FASLG IL1B NLRP3
11 osteoporosis 29.7 IL1A IL1B IL1RN TGFB1 TNF
12 mycobacterium kansasii 29.7 CXCL8 NLRP3
13 lung disease 29.6 CCL2 CXCL8 IL1B SFTPD TGFB1 TNF
14 autoimmune disease 29.5 CCL2 DSG1 FAS IL1B IL1RN TNF
15 systemic scleroderma 29.4 ACE SFTPD TGFB1
16 pneumonia 29.4 CCL2 CXCL8 IL1B SFTPD TNF
17 extrinsic allergic alveolitis 29.3 CCL2 CXCL8 IL1B SFTPD
18 sarcoidosis 1 29.3 ACE CCL2 IL1B SCGB1A1 TNF
19 arthritis 29.3 CCL2 CXCL8 IL1A IL1B IL1RN TGFB1
20 pulmonary disease, chronic obstructive 29.2 CCL2 CXCL8 SCGB1A1 SFTPD TGFB1 TNF
21 systemic lupus erythematosus 29.2 ACE CCL2 CXCL8 FAS FASLG IL1B
22 iga glomerulonephritis 29.1 ACE CCL2 SCGB1A1 TGFB1
23 rheumatoid arthritis 28.9 CCL2 CXCL8 IL1A IL1B IL1RN TGFB1
24 pulmonary fibrosis, idiopathic 28.6 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
25 asthma 28.3 CCL2 CXCL8 FAS IL1A IL1B IL1RN
26 beryllium disease 11.1
27 lung cancer 10.7
28 pneumoconiosis due to talc 10.5
29 asbestosis 10.4
30 burns 10.3 IL1B TNF
31 glossitis 10.3 IL1B TNF
32 rheumatoid lung disease 10.3 IL1B TNF
33 juvenile ankylosing spondylitis 10.3 IL1RN TNF
34 scleral disease 10.3 IL1RN TNF
35 lymphomatoid papulosis 10.3 FAS FASLG
36 pustulosis of palm and sole 10.3 IL1RN TNF
37 skin conditions 10.3 IL1A TNF
38 gastric cancer, hereditary diffuse 10.3 IL1B IL1RN
39 chronic graft versus host disease 10.3 IL1A TNF
40 trichuriasis 10.3 CXCL8 TNF
41 cardiac sarcoidosis 10.3 CXCL8 TNF
42 streptococcal toxic-shock syndrome 10.3 CXCL8 TNF
43 funisitis 10.3 CXCL8 IL1B
44 peptic esophagitis 10.3 CXCL8 IL1B
45 pneumothorax 10.3
46 pouchitis 10.3 CXCL8 IL1RN
47 scleroderma, familial progressive 10.3
48 scabies 10.3 CXCL8 IL1A
49 chronic follicular conjunctivitis 10.2 IL1A IL1B
50 systemic onset juvenile idiopathic arthritis 10.2 IL1RN TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis

Symptoms & Phenotypes for Silicosis

GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 ACE CXCL8 FAS IL1A IL1B NLRP3
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 ACE CXCL8 FAS IL1A IL1B NLRP3

MGI Mouse Phenotypes related to Silicosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.16 ACE DSG1 FAS IL1B IL1RN NLRP3
2 immune system MP:0005387 10.15 ACE CCL2 FAS FASLG IL1A IL1B
3 homeostasis/metabolism MP:0005376 10.14 ACE FAS FASLG IL1A IL1B IL1RN
4 hematopoietic system MP:0005397 10.13 ACE FAS FASLG IL1A IL1B IL1RN
5 cardiovascular system MP:0005385 10.08 ACE FAS FASLG IL1A IL1B IL1RN
6 integument MP:0010771 9.97 DSG1 FAS FASLG IL1A IL1B IL1RN
7 neoplasm MP:0002006 9.76 ACE FAS FASLG IL1A IL1B SCGB1A1
8 liver/biliary system MP:0005370 9.73 ACE FAS FASLG NLRP3 TGFB1 TNF
9 renal/urinary system MP:0005367 9.43 ACE FAS FASLG NLRP3 SCGB1A1 TGFB1
10 skeleton MP:0005390 9.23 DSG1 FAS FASLG IL1B IL1RN NLRP3

Drugs & Therapeutics for Silicosis

Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
3
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
4 Antitubercular Agents Phase 3
5 Nucleic Acid Synthesis Inhibitors Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Cytochrome P-450 CYP3A Inducers Phase 3
8 Lipid Regulating Agents Phase 3
9 Antimetabolites Phase 3
10 Anti-Infective Agents Phase 3
11 Hypolipidemic Agents Phase 3
12 Anti-Bacterial Agents Phase 3
13 Mitogens Phase 1, Phase 2
14 Respiratory System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Unknown status NCT02430259 Phase 3 Weekly INH / RRT given by DOT
2 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
4 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Active, not recruiting NCT02668068 Phase 1
5 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
6 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
7 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
8 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
9 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

Anatomical Context for Silicosis

MalaCards organs/tissues related to Silicosis:

41
Lung, Bone, Bone Marrow, Testes, Lymph Node, T Cells, Skin

Publications for Silicosis

Articles related to Silicosis:

(show top 50) (show all 1067)
# Title Authors Year
1
Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model. ( 30394303 )
2019
2
Lung Cancer Mortality in Tuscany from 1971 to 2010 and Its Connections with Silicosis: A Space-Cohort Analysis Based on Shared Models. ( 29796059 )
2018
3
Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis. ( 29856822 )
2018
4
Clinical features of secondary spontaneous pneumothorax complicated with silicosis. ( 29548652 )
2018
5
The Role of Fibrocyte in the Pathogenesis of Silicosis. ( 29773095 )
2018
6
Erasmus syndrome: systemic sclerosis and silicosis co-occurrence. ( 29667340 )
2018
7
Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats. ( 29673394 )
2018
8
Response to: 'Artificial stone-associated silicosis in the UK' by Barber <i>et al</i>. ( 29574403 )
2018
9
Pulmonary tuberculosis in a male with silicosis. ( 29960278 )
2018
10
Inflammatory and oxidative stress parameters as potential early biomarkers for silicosis. ( 29860036 )
2018
11
Pleuroparenchymal Fibroelastosis and Silicosis: An Unexpected Association. ( 29580565 )
2018
12
Erasmus Syndrome: Association of Silicosis and Systemic Sclerosis. ( 29854640 )
2018
13
Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse. ( 29755467 )
2018
14
Artificial stone-associated silicosis in the UK. ( 29444932 )
2018
15
Percutaneous treatment for silicosis-induced pulmonary artery stenosis: A case report and review of the literature. ( 29480834 )
2018
16
Proximal limb weakness and amyotrophy in a man with silicosis. ( 29364397 )
2018
17
Silicosis decreases bone mineral density in rats. ( 29680408 )
2018
18
Comparison of digital and film chest radiography for detection and medical surveillance of silicosis in a setting with a high burden of tuberculosis. ( 29210092 )
2018
19
Silicosis in Turkey: Is it an Endless Nightmare or is There Still Hope? ( 29755813 )
2018
20
Archival sources on asbestos and silicosis in Southern Africa and Australia. ( 29348448 )
2018
21
Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis. ( 29843724 )
2018
22
The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population. ( 29621588 )
2018
23
EBUS-TBNA is Sufficient for Successful Diagnosis of Silicosis with Mediastinal Lymphadenopathy. ( 29845341 )
2018
24
A Rare Cause of Dysphagia and Cough: Bronchoesophageal Fistula from Silicosis. ( 30465007 )
2018
25
Silica, silicosis and lung cancer: what level of exposure is acceptable? ( 30556538 )
2018
26
Silicosis and lung cancer: current perspectives. ( 30498384 )
2018
27
Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population. ( 30257124 )
2018
28
Computed tomography findings of arc-welders' pneumoconiosis: Comparison with silicosis. ( 30292280 )
2018
29
Comparative RNA-Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis model. ( 29341224 )
2018
30
Silicosis in Switzerland. ( 30010160 )
2018
31
Regulation of TLR4 in silica-induced inflammation: An underlying mechanism of silicosis. ( 30013439 )
2018
32
Retrospective Assessment of Respirable Quartz Exposure for a Silicosis Study of the Industrial Sand Industry. ( 30016388 )
2018
33
A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report. ( 30023036 )
2018
34
A case of accelerated silicosis. ( 30053129 )
2018
35
The 6-Minute Walk Test as a Tool for Determining Exercise Capacity and Prognosis in Patients with Silicosis. ( 30100206 )
2018
36
The Burden of Silicosis in Michigan: 1988-2016. ( 30188758 )
2018
37
A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk. ( 30207747 )
2018
38
Silica Exposure, Silicosis, and the New Occupational Safety and Health Administration Silica Standard. What Pulmonologists Need to Know. ( 30211615 )
2018
39
Nicorandil ameliorates pulmonary inflammation and fibrosis in a rat model of silicosis. ( 30223191 )
2018
40
Subradiological silicosis. ( 30239033 )
2018
41
Silicosis: A former occupational disease with new occupational exposure scenarios. ( 30293675 )
2018
42
Erratum: Silicosis in Turkey: Is It an Endless Nightmare? ( 30307846 )
2018
43
Assessment of Silicosis Awareness among Stone Mine Workers of Rajasthan State. ( 30319231 )
2018
44
Artificial stone-associated silicosis in Belgium. ( 30385463 )
2018
45
Epidemiology of silicosis: reports from the SWORD scheme in the UK from 1996 to 2017. ( 30415232 )
2018
46
Exposure‒response relationships for silicosis and its progression in industrial sand workers. ( 30448860 )
2018
47
Silicosis in underground miners in Lubumbashi, Democratic Republic of the Congo: 27 cases. ( 30499446 )
2018
48
Silicosis, sarcoidosis and systemic sclerosis in the same patient. ( 30502296 )
2018
49
Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust. ( 30514749 )
2018
50
MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model. ( 30529807 )
2018

Variations for Silicosis

Expression for Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for Silicosis

Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CXCL8 DSG1 FASLG IL1A IL1B
2
Show member pathways
13.85 CCL2 CXCL8 FAS FASLG IL1A IL1B
3
Show member pathways
13.65 CCL2 CXCL8 FAS FASLG IL1A IL1B
4
Show member pathways
13.54 CXCL8 FAS FASLG IL1A IL1B TGFB1
5
Show member pathways
13.41 CCL2 CXCL8 FAS FASLG IL1A IL1B
6
Show member pathways
13.33 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
7
Show member pathways
13.3 CCL2 CXCL8 FAS FASLG IL1A IL1B
8
Show member pathways
13.06 CCL2 CXCL8 FAS FASLG IL1B TGFB1
9
Show member pathways
12.93 CCL2 FAS FASLG TNF TNFRSF6B
10
Show member pathways
12.88 CXCL8 FAS FASLG IL1A IL1B TGFB1
11 12.79 FAS FASLG IL1A IL1B TGFB1 TNF
12
Show member pathways
12.72 CCL2 CXCL8 FAS FASLG IL1A IL1B
13
Show member pathways
12.71 ACE CCL2 CXCL8 FAS FASLG IL1B
14
Show member pathways
12.7 FAS FASLG IL1A IL1B TNF
15
Show member pathways
12.64 FAS FASLG IL1A IL1B TNF
16
Show member pathways
12.58 IL1A IL1B TGFB1 TNF
17 12.58 CCL2 FAS FASLG IL1B IL1RN TNF
18
Show member pathways
12.46 FAS IL1A IL1B TGFB1 TNF
19
Show member pathways
12.35 CCL2 CXCL8 IL1B TNF
20
Show member pathways
12.33 CCL2 IL1A IL1B IL1RN
21
Show member pathways
12.32 CXCL8 IL1A IL1B TNF
22 12.32 FAS FASLG TGFB1 TNF
23
Show member pathways
12.3 FAS FASLG IL1A TNF TNFRSF6B
24
Show member pathways
12.29 CXCL8 IL1A IL1B TGFB1 TNF
25
Show member pathways
12.28 IL1A IL1B TGFB1 TNF
26 12.27 FAS FASLG TNF TNFRSF6B
27
Show member pathways
12.26 CXCL8 IL1A IL1B IL1RN TNF
28 12.25 IL1A IL1B TGFB1 TNF
29 12.22 CXCL8 IL1A IL1B IL1RN TNF
30
Show member pathways
12.21 FAS FASLG IL1A IL1B NLRP3 TNF
31
Show member pathways
12.17 CXCL8 FAS FASLG IL1B SFTPD TNF
32 12.12 CCL2 IL1A IL1B TNF
33
Show member pathways
12.1 CCL2 CXCL8 IL1A IL1B TGFB1
34 12.08 IL1A IL1B TGFB1 TNF
35 12.04 FAS TGFB1 TNF
36
Show member pathways
12.03 IL1B TGFB1 TNF
37 12.01 CCL2 FAS IL1B TNF
38 11.99 CXCL8 IL1A IL1B TGFB1
39 11.93 CXCL8 IL1B TGFB1 TNF
40 11.92 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
41 11.9 IL1A IL1B TNF
42 11.89 CXCL8 IL1B TNF
43 11.84 CXCL8 IL1A IL1B
44 11.8 CXCL8 IL1A IL1B NLRP3 TNF
45
Show member pathways
11.79 CXCL8 FASLG TNF
46 11.79 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
47 11.77 IL1B TGFB1 TNF
48 11.76 CCL2 IL1B IL1RN TGFB1 TNF
49
Show member pathways
11.72 CXCL8 IL1A IL1B TNF
50 11.69 CCL2 CXCL8 IL1A IL1B TGFB1 TNF

GO Terms for Silicosis

Cellular components related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE CCL2 CXCL8 FASLG IL1A IL1B
2 lysosome GO:0005764 9.56 ACE FASLG IL1B SFTPD
3 extracellular region GO:0005576 9.47 ACE CCL2 CXCL8 FAS FASLG IL1A
4 secretory granule GO:0030141 9.33 IL1B SCGB1A1 TGFB1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.98 CCL2 IL1B TGFB1 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.94 FAS IL1B TGFB1 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.94 FASLG IL1B IL1RN TNF
4 female pregnancy GO:0007565 9.88 IL1RN SCGB1A1 TGFB1
5 response to organic substance GO:0010033 9.88 SCGB1A1 TGFB1 TNF
6 positive regulation of JNK cascade GO:0046330 9.88 IL1B IL1RN TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B NLRP3 TGFB1 TNF
8 cellular response to mechanical stimulus GO:0071260 9.87 FAS IL1B TGFB1
9 regulation of inflammatory response GO:0050727 9.87 NLRP3 SCGB1A1 TNF
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.86 FASLG TNF TNFRSF6B
11 immune response GO:0006955 9.86 CCL2 CXCL8 FAS FASLG IL1A IL1B
12 apoptotic signaling pathway GO:0097190 9.85 FAS FASLG TNF
13 positive regulation of interleukin-6 production GO:0032755 9.84 IL1B IL1RN TNF
14 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.84 FAS FASLG NLRP3 TNF
15 neutrophil chemotaxis GO:0030593 9.83 CCL2 CXCL8 IL1B IL1RN
16 interleukin-1-mediated signaling pathway GO:0070498 9.82 IL1A IL1B IL1RN
17 positive regulation of cell division GO:0051781 9.81 IL1A IL1B TGFB1
18 cellular response to organic cyclic compound GO:0071407 9.81 CCL2 IL1B TGFB1 TNF
19 negative regulation of T cell proliferation GO:0042130 9.8 SCGB1A1 SFTPD TGFB1
20 response to glucocorticoid GO:0051384 9.8 IL1B IL1RN SCGB1A1 TNF
21 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL8 IL1B IL1RN NLRP3 TNF
22 positive regulation of JUN kinase activity GO:0043507 9.79 IL1B IL1RN TNF
23 positive regulation of phagocytosis GO:0050766 9.78 IL1B SFTPD TNF
24 extrinsic apoptotic signaling pathway GO:0097191 9.78 FAS FASLG TGFB1 TNF
25 protein kinase B signaling GO:0043491 9.76 CCL2 IL1B TGFB1 TNF
26 regulation of signaling receptor activity GO:0010469 9.76 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
27 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.74 IL1A IL1B TNF
28 response to vitamin D GO:0033280 9.73 IL1B TGFB1
29 positive regulation of histone acetylation GO:0035066 9.73 IL1B TGFB1
30 embryonic digestive tract development GO:0048566 9.73 CXCL8 TNF
31 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
32 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B TNF
33 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.73 FAS FASLG
34 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
37 positive regulation of vascular endothelial growth factor production GO:0010575 9.72 IL1A IL1B TGFB1
38 macrophage chemotaxis GO:0048246 9.71 CCL2 SFTPD
39 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.71 IL1A IL1B
40 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 IL1B TGFB1 TNF
42 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
43 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
44 negative regulation of glutamate secretion GO:0014050 9.68 IL1B IL1RN
45 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
46 positive regulation of neuroinflammatory response GO:0150078 9.67 IL1B TNF
47 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.66 IL1A TGFB1
48 interleukin-1 beta production GO:0032611 9.66 IL1B NLRP3
49 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
50 response to ozone GO:0010193 9.65 IL1B SCGB1A1

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 protein binding GO:0005515 10 CCL2 CXCL8 DSG1 FAS FASLG IL1A

Sources for Silicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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