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MCID: SLC006
MIFTS: 56

Silicosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Silicosis

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MalaCards integrated aliases for Silicosis:

Name: Silicosis 12 74 52 54 43 15 17 71
Silicotuberculosis 12 71
Chronic Silicosis 52 71
Acute Silicosis 52 71
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 52
Silica Pneumoconiosis 12
Accelerated Silicosis 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10325
ICD9CM 34 502
MeSH 43 D012829
NCIt 49 C3369
SNOMED-CT 67 805002
ICD10 32 J62.8
UMLS 71 C0037116 C0037118 C0340190 more
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Summaries for Silicosis

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NIH Rare Diseases : 52 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to anthracosis and asbestosis. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Rifapentine and Isoniazid have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and lymph node, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 74 Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. It is... more...

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Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 707)
# Related Disease Score Top Affiliating Genes
1 anthracosis 33.3 TNF TGFB1 IL1B CCL2
2 asbestosis 31.4 NLRP3 IL1B CASP1
3 bronchitis 31.3 TNF IL4 IL1B IL10 CXCL8
4 pulmonary fibrosis 31.3 TGFB1 SFTPD IL1B CXCL8 CCL2
5 pulmonary emphysema 31.0 SFTPD HMOX1 CXCL8
6 glomerulonephritis 30.9 TGFB1 SCGB1A1 IL1B CCL2
7 mycobacterium tuberculosis 1 30.8 TNF IL4 IL18 IL17A IL10
8 pericarditis 30.8 TNF IL1RN IL1B CXCL8
9 pulmonary tuberculosis 30.7 TNF IL4 IL1B IL18 IL10 CCL2
10 bagassosis 30.7 IL1B CXCL8
11 vasculitis 30.7 TNF IL17A IL10 CCL2
12 bronchopneumonia 30.6 TNF IL1B IL10 CXCL8
13 interstitial lung disease 30.6 TNF TGFB1 SFTPD IL4 IL1B IL1A
14 mycobacterium kansasii 30.5 NLRP3 CXCL8
15 pulmonary alveolar proteinosis 30.5 TNF SFTPD IL10 CXCL8 CCL2
16 pemphigus 30.5 TNF IL4 IL10 DSG1
17 respiratory failure 30.5 TNF SFTPD SCGB1A1 IL1RN IL1B IL10
18 histiocytosis 30.5 TNF IL1RN IL17A
19 bullous pemphigoid 30.4 TNF IL4 DSG1 CXCL8
20 systemic scleroderma 30.4 TNF TGFB1 SFTPD IL4 IL1B IL17A
21 pleural disease 30.4 TNF IL1B CXCL8
22 purpura 30.4 TNF IL4 IL10
23 autoimmune lymphoproliferative syndrome 30.4 TNF IL10 FASLG FAS
24 pulmonary sarcoidosis 30.4 TNF SFTPD IL18 CCL2
25 cryptogenic organizing pneumonia 30.4 TNF SFTPD CXCL8
26 cryoglobulinemia 30.3 TNF IL1B IL10
27 paracoccidioidomycosis 30.3 TNF IL4 IL10
28 pulmonary hypertension 30.2 TNF IL1B IL10 HMOX1 CXCL8 CCL2
29 sarcoidosis 1 30.2 TNF SFTPD SCGB1A1 IL1RN IL1B IL1A
30 endocarditis 30.2 TNF IL1A IL17A IL10 CXCL8
31 mycetoma 30.1 IL17A IL10 CXCL8
32 pleurisy 30.1 TNF TGFB1 IL1RN CXCL8 CCL2
33 dysentery 30.1 TNF IL1B IL1A IL10 CXCL8
34 peptic ulcer disease 30.1 TNF IL1RN IL1B IL10 CXCL8
35 pharyngitis 30.0 TNF NLRP3 IL1RN IL1B CXCL8
36 allergic hypersensitivity disease 30.0 TNF SFTPD IL4 IL17A IL10 CXCL8
37 adult respiratory distress syndrome 30.0 TNF SFTPD IL1B IL10 CXCL8
38 spondylitis 30.0 TNF IL1RN IL17A IL10
39 idiopathic interstitial pneumonia 30.0 TGFB1 SFTPD IL4 CXCL8 CCL2
40 cryptococcosis 30.0 TNF IL4 IL17A IL10
41 chronic kidney disease 29.9 TNF TGFB1 IL1B IL10 HMOX1 CCL2
42 hemolytic anemia 29.9 TNF IL4 IL10 HMOX1 FASLG
43 toxic shock syndrome 29.9 TNF IL4 IL1RN IL1B IL10 CXCL8
44 lymphopenia 29.8 IL4 IL18 IL10 FASLG FAS
45 crescentic glomerulonephritis 29.8 TNFRSF6B SCGB1A1 IL1RN CCL2
46 extrapulmonary tuberculosis 29.7 TNF IL1RN IL1B IL1A IL10 CCL2
47 pulmonary edema 29.7 TNF SCGB1A1 IL1B IL10 HMOX1 FASLG
48 connective tissue disease 29.6 TNF SFTPD IL4 IL1B IL1A IL17A
49 lymphadenitis 29.6 TNF IL1B IL18 IL10 FASLG FAS
50 spondyloarthropathy 1 29.6 TNF IL1RN IL17A

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis
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Symptoms & Phenotypes for Silicosis

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GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 10 CASP1 HMOX1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 10 CASP1 FAS FASLG HMOX1 IL10 IL18
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 10 IL1A
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.68 CXCL8 FAS IL10 IL17A IL18 IL1A
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.68 CASP1 CXCL8 FAS HMOX1 IL10 IL17A
6 Reduced mammosphere formation GR00396-S 9.5 CASP1 CCL2 CXCL8 FAS FASLG IL17A

MGI Mouse Phenotypes related to Silicosis:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 CASP1 FAS FASLG HMOX1 IL10 IL17A
2 immune system MP:0005387 10.39 CASP1 CCL2 FAS FASLG HMOX1 IL10
3 homeostasis/metabolism MP:0005376 10.38 CASP1 FAS FASLG HMOX1 IL10 IL17A
4 growth/size/body region MP:0005378 10.36 DSG1 FAS HMOX1 IL10 IL17A IL18
5 cellular MP:0005384 10.34 CASP1 FAS FASLG HMOX1 IL10 IL18
6 cardiovascular system MP:0005385 10.31 CASP1 FAS FASLG HMOX1 IL10 IL18
7 integument MP:0010771 10.28 CASP1 DSG1 FAS FASLG IL10 IL17A
8 digestive/alimentary MP:0005381 10.24 CASP1 FAS FASLG IL10 IL17A IL18
9 mortality/aging MP:0010768 10.24 CASP1 FAS FASLG HMOX1 IL10 IL17A
10 endocrine/exocrine gland MP:0005379 10.22 CASP1 FAS FASLG HMOX1 IL10 IL17A
11 craniofacial MP:0005382 10.09 FAS IL10 IL17A IL1B IL4 TGFB1
12 liver/biliary system MP:0005370 10.01 FAS FASLG HMOX1 IL10 IL4 NLRP3
13 neoplasm MP:0002006 9.97 CASP1 FAS FASLG IL10 IL1A IL1B
14 renal/urinary system MP:0005367 9.91 CASP1 FAS FASLG HMOX1 IL17A IL4
15 reproductive system MP:0005389 9.85 CASP1 FAS FASLG HMOX1 IL10 IL1RN
16 respiratory system MP:0005388 9.65 FAS FASLG HMOX1 IL10 IL17A IL4
17 skeleton MP:0005390 9.36 DSG1 FAS FASLG IL10 IL17A IL1B
Sources

Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
2
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
3 Antitubercular Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Hypolipidemic Agents Phase 3
6 Anti-Bacterial Agents Phase 3
7 Lipid Regulating Agents Phase 3
8 Antibiotics, Antitubercular Phase 3
9 Antimetabolites Phase 3
10
Nintedanib Approved Phase 2 656247-17-5 56843413
11 Mitogens Phase 1, Phase 2
12
Cocaine Approved, Illicit 50-36-2 446220 5760
13
Rifampicin Approved 13292-46-1 5381226 5458213
14 Respiratory System Agents
15 Anesthetics
16
protease inhibitors
17 HIV Protease Inhibitors

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Effectiveness and Tolerability of Weekly Rifapentine/Isoniazid for 3 Months for Tuberculosis Preventive Treatment: A Randomized Controlled Study in China Unknown status NCT02430259 Phase 3 Weekly INH / RRT given by DOT
2 Phase 1 Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Not yet recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
4 Phase-1 Study of Autologous Bone Marrow Cells Intrabronchial Instillation for Patients Silicosis Completed NCT01239862 Phase 1
5 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
6 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
7 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
8 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
9 The Use of Forced Oscillation Technique in the Analysis of Respiratory System in Never-smoking Patients With Silicosis:Pathophysiological Study and Evaluation of Diagnostic Accuracy Completed NCT01725971
10 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
11 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Recruiting NCT04205708
12 Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB) Recruiting NCT03900858 Isoniazidï¼›Rifapentine
13 Respiratory Impairment in Mucopolysaccharidosis Patients: Impact of Glycosaminoglycans (GAG) on the Proteases/Antiproteases Balance Not yet recruiting NCT04112602

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

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Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

40
Lung, Testes, Lymph Node, Bone, Heart, Skin, Liver
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Publications for Silicosis

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Articles related to Silicosis:

(show top 50) (show all 5646)
# Title Authors PMID Year
1
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. 54 61
18666137 2008
2
[Polymorphisms of FAS and FASL genes and susceptibility of silicosis]. 54 61
18302883 2008
3
Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis. 54 61
17693780 2007
4
Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages. 54 61
17393098 2007
5
[Changes of Clara cell protein and surfactant protein-D in serum of patients with silicosis]. 61 54
17374182 2007
6
Apoptosis and extracellular matrix remodelling in human silicosis. 54 61
16918975 2006
7
Alterations of Fas and Fas-related molecules in patients with silicosis. 61 54
16636300 2006
8
Detection, epitope-mapping and function of anti-Fas autoantibody in patients with silicosis. 61 54
16108814 2005
9
[Sudy on the activation of early growth response factor-1 by silica dioxide and its signal pathway]. 54 61
16181552 2005
10
[Dysregulation of Fas and related molecules in silicosis patients]. 61 54
15773295 2005
11
[The role of Egr-1 and NF-kappaB in the pathogenesis of silicosis: an in-vitro study]. 54 61
15363325 2004
12
The central role of Fas-ligand cell signaling in inflammatory lung diseases. 54 61
15491504 2004
13
[Expression of early growth response gene-1 in macrophages stimulated by silicon dioxide]. 61 54
14761604 2003
14
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. 61 54
14514471 2003
15
Significance of genetic information in risk assessment and individual classification using silicosis as a case model. 54 61
12176706 2002
16
Polymorphisms of the IL-1 gene complex in coal miners with silicosis. 54 61
11241561 2001
17
Antidesmoglein autoantibodies in silicosis patients with no bullous diseases. 61 54
11244222 2001
18
Detection of alternatively spliced variant messages of Fas gene and mutational screening of Fas and Fas ligand coding regions in peripheral blood mononuclear cells derived from silicosis patients. 61 54
10841950 2000
19
Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients. 61 54
10632670 2000
20
Serum levels of soluble Fas ligand in patients with silicosis. 54 61
10594565 1999
21
Soluble Fas mRNA is dominantly expressed in cases with silicosis. 61 54
9741350 1998
22
Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumours. 61 54
9367417 1997
23
Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition. 61
32218530 2020
24
Silica dust exposure induces autophagy in alveolar macrophages through switching Beclin1 affinity from Bcl-2 to PIK3C3. 61
32061152 2020
25
Pulmonary function and high-resolution computed tomography in outdoor rock drillers exposed to crystalline silica. 61
32571792 2020
26
Estimation of the number of workers exposed to respirable crystalline silica by industry: Analysis of OSHA compliance data (1979-2015). 61
32270550 2020
27
Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling. 61
32464548 2020
28
Efficacy and safety of weekly rifapentine and isoniazid for tuberculosis prevention in Chinese silicosis patients: a randomized controlled trial. 61
32553881 2020
29
Predictors of silicosis and variation in prevalence across mines among employed gold miners in South Africa. 61
32487111 2020
30
Performance Comparison of Four Portable FTIR Instruments for Direct-on-Filter Measurement of Respirable Crystalline Silica. 61
32266371 2020
31
Trends in Pneumoconiosis Deaths - United States, 1999-2018. 61
32525855 2020
32
Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017. 61
32188634 2020
33
Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis. 61
32538526 2020
34
Artificial Stone Silicosis: Rapid Progression Following Exposure Cessation. 61
32563682 2020
35
Artificial Stone Silicosis: Removal From Exposure Is Not Enough. 61
32563683 2020
36
Differential expression of lncRNAs during silicosis and the role of LOC103691771 in myofibroblast differentiation induced by TGF-β1. 61
32028236 2020
37
High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis. 61
32428545 2020
38
Silicosis: An ancient disease in need of a dose of modern medicine. 61
31970870 2020
39
Prevalence and Clinical Impact of Systemic Autoimmune Rheumatic Disease in Patients with Silicosis. 61
32493645 2020
40
Overexpression of endogenous lipoic acid synthase attenuates pulmonary fibrosis induced by crystalline silica in mice. 61
32017981 2020
41
PolyG mitigates silica-induced pulmonary fibrosis by inhibiting nucleolin and regulating DNA damage repair pathway. 61
32036217 2020
42
Inhalation of Tetrandrine-hydroxypropyl-β-cyclodextrin Inclusion Complexes for Pulmonary Fibrosis Treatment. 61
32142292 2020
43
Artificial stone-associated silicosis in China: A prospective comparison with natural stone-associated silicosis. 61
31828940 2020
44
Silica particles disorganize the polarization of pulmonary macrophages in mice. 61
32114243 2020
45
Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen. 61
31953962 2020
46
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation. 61
32059163 2020
47
Silicosis in artificial stone workers: Spectrum of radiological high-resolution CT chest findings. 61
32157793 2020
48
Club cell protein 16 as a biomarker for early detection of silicosis. 61
32461395 2020
49
Computer-assisted interpretation of chest radiographs: signs of hope for silicosis and tuberculosis. 61
32317057 2020
50
Computer-aided detection for tuberculosis and silicosis in chest radiographs of gold miners of South Africa. 61
32317070 2020
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Variations for Silicosis

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Expression for Silicosis

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Search GEO for disease gene expression data for Silicosis.
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Pathways for Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.11 TNFRSF6B TNF TGFB1 NLRP3 IL4 IL1RN
2
ERK Signaling 63
Show member pathways
 13.95 TNFRSF6B TNF TGFB1 IL4 IL1B IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.75 TNFRSF6B TNF TGFB1 IL4 IL1RN IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.66 TNF TGFB1 IL4 IL1B IL1A IL18
5
Akt Signaling 63
Show member pathways
 13.56 TNF TGFB1 IL4 IL1B IL1A IL18
6
PAK Pathway 63
Show member pathways
 13.39 TNF TGFB1 IL4 IL1B IL1A IL18
7
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 13.36 TNF TGFB1 IL1B IL1A FASLG FAS
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.22 TNF TGFB1 SFTPD IL1B IL10 FASLG
9
Cytokine Signaling in Immune system 65
Show member pathways
 13.14 TNFRSF6B TNF TGFB1 IL4 IL1RN IL1B
10
Human cytomegalovirus infection 36
Show member pathways
 13.02 TNF IL1B FASLG FAS CXCL8 CCL2
11
Allograft rejection 1 36
Show member pathways
 13.01 TNF TGFB1 IL4 IL1B IL1A IL17A
12
Measles 36
Show member pathways
 12.96 TNF NLRP3 IL1B IL1A IL18 FASLG
13
Pathways in cancer 36
12.95 TGFB1 IL4 HMOX1 FASLG FAS CXCL8
14
MAPK signaling pathway 36 1
12.91 TNF TGFB1 IL1B IL1A FASLG FAS
15
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.89 TNF NLRP3 IL1RN IL1B IL1A IL18
16
Herpes simplex virus 1 infection 36
12.85 TNF IL1B FASLG FAS CCL2
17
T cell receptor signaling pathway 36
Show member pathways
 12.8 TNF TGFB1 IL4 IL1B IL1A IL17A
18
Th17 cell differentiation 36
Show member pathways
 12.79 TNF TGFB1 IL4 IL1B IL1A IL18
19
Apoptosis Modulation and Signaling 1
Show member pathways
 12.78 TNFRSF6B TNF FASLG FAS CASP1
20
4-1BB Pathway 63
Show member pathways
 12.75 TNF IL1B IL1A FASLG FAS
21
Immune response IL-23 signaling pathway 22
Show member pathways
 12.73 TNF IL1B IL18 IL17A IL10 CCL2
22
TRAF Pathway 63
Show member pathways
 12.72 TNF IL1B IL1A FASLG FAS CASP1
23
NF-kappaB Signaling 4
12.58 TNF IL4 IL1RN IL1B IL17A IL10
24
Shigellosis 36
12.56 TNF NLRP3 IL1B IL18 CXCL8 CASP1
25
IL-17 Family Signaling Pathways 64
Show member pathways
 12.5 TNF IL4 IL1B IL17A CXCL8 CCL2
26
Salmonella infection (KEGG) 36
12.48 TNF NLRP3 IL1B IL18 CXCL8 CASP1
27
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.47 TNF IL18 IL10 CXCL8 CCL2
28
IL-1 signaling pathway 1
Show member pathways
 12.44 IL1RN IL1B IL1A CCL2 CASP1
29
Toxoplasmosis 36
Show member pathways
 12.44 TNF TGFB1 IL4 IL1B IL1A IL10
30
NOD-like receptor signaling pathway 36
12.44 TNF NLRP3 IL1B IL18 CXCL8 CCL2
31
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.44 TNF TGFB1 IL4 IL1B IL1A IL18
32
Pathogenic Escherichia coli infection 36
12.43 TNF NLRP3 IL1B IL18 FASLG FAS
33
Tuberculosis 36
12.41 TNF TGFB1 IL1B IL1A IL18 IL10
34
Necroptosis 36
Show member pathways
 12.4 TNF NLRP3 IL1B IL1A FASLG FAS
35
Folate Metabolism 1
Show member pathways
 12.39 TNF IL4 IL1B CCL2
36
Apoptosis and Autophagy 4
12.39 TNFRSF6B TNF FASLG FAS CASP1
37
Proteoglycans in cancer 36
12.37 TNF TGFB1 FASLG FAS
38
Apoptosis and survival Caspase cascade 22
Show member pathways
 12.37 TNF IL1A FASLG FAS CASP1
39
Bacterial infections in CF airways 22
Show member pathways
 12.37 TNF SFTPD IL4 IL1B FASLG FAS
40
C-type lectin receptor signaling pathway 36
Show member pathways
 12.36 TNF NLRP3 IL1B IL10 CASP1
41
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.36 TNF IL1RN IL1B IL1A IL10 CXCL8
42
Fluid shear stress and atherosclerosis 36
12.25 TNF IL1B IL1A HMOX1 CCL2
43
Spinal Cord Injury 1
12.21 TNF TGFB1 IL4 IL1B IL1A CXCL8
44
Osteoclast differentiation 36
12.16 TNF TGFB1 IL1B IL1A
45
IL27-mediated signaling events 1
Show member pathways
 12.16 TNF TGFB1 IL1B IL18 IL17A IL10
46
AGE-RAGE signaling pathway in diabetic complications 36
12.14 TNF TGFB1 IL1B IL1A CXCL8 CCL2
47
IL12-mediated signaling events 1
Show member pathways
 12.1 IL4 IL1B IL18 FASLG
48
Amoebiasis 36
12.1 TNF TGFB1 IL1B IL10 CXCL8
49
TNF signaling pathway 36
12.09 TNF IL1B FAS CCL2
50
Yersinia infection 36
12.09 TNF NLRP3 IL1B IL18 IL10 CXCL8
Sources

GO Terms for Silicosis

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Cellular components related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 TNFRSF6B TNF TGFB1 SFTPD SCGB1A1 NLRP3
2 extracellular space GO:0005615 9.53 TNFRSF6B TNF TGFB1 SFTPD SCGB1A1 IL4
3 NLRP3 inflammasome complex GO:0072559 9.16 NLRP3 CASP1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 TNF TGFB1 NLRP3 IL4 IL1B IL1A
2 signal transduction GO:0007165 10.18 TGFB1 SCGB1A1 NLRP3 IL4 IL1RN IL1B
3 positive regulation of gene expression GO:0010628 10.14 TNF TGFB1 IL4 IL1B IL1A IL18
4 negative regulation of cell proliferation GO:0008285 10.13 TGFB1 IL1B IL1A IL10 HMOX1 CXCL8
5 positive regulation of apoptotic process GO:0043065 10.12 TNF TGFB1 HMOX1 FASLG FAS
6 apoptotic process GO:0006915 10.09 TNFRSF6B NLRP3 IL1B IL1A IL17A HMOX1
7 cell-cell signaling GO:0007267 10.06 IL1B IL18 IL17A FASLG
8 MAPK cascade GO:0000165 10.06 TNF TGFB1 IL1B IL18 CCL2
9 positive regulation of protein phosphorylation GO:0001934 10.03 TNF TGFB1 IL1B FAS
10 response to lipopolysaccharide GO:0032496 10.02 SCGB1A1 IL1B IL10 FASLG
11 positive regulation of angiogenesis GO:0045766 10.01 IL1B IL1A HMOX1 CXCL8
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.01 TNF TGFB1 NLRP3 IL1B IL18
13 tumor necrosis factor-mediated signaling pathway GO:0033209 9.97 TNFRSF6B TNF FASLG FAS
14 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 TNF IL1B IL1A HMOX1 FASLG CASP1
15 regulation of inflammatory response GO:0050727 9.94 TNF SCGB1A1 NLRP3 CASP1
16 response to organic substance GO:0010033 9.94 TNF TGFB1 SCGB1A1 IL10
17 cellular response to interleukin-1 GO:0071347 9.93 IL17A CXCL8 CCL2
18 neutrophil chemotaxis GO:0030593 9.93 IL1B CXCL8 CCL2
19 cellular response to mechanical stimulus GO:0071260 9.93 TGFB1 IL1B FAS CASP1
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL4 IL18
21 apoptotic signaling pathway GO:0097190 9.92 TNF FASLG FAS CASP1
22 response to glucocorticoid GO:0051384 9.92 TNF SCGB1A1 IL1RN IL10
23 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF IL1B IL18
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF IL18 HMOX1
25 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.9 TNF NLRP3 CASP1
26 positive regulation of phagocytosis GO:0050766 9.89 TNF SFTPD IL1B
27 positive regulation of cell division GO:0051781 9.89 TGFB1 IL1B IL1A
28 extrinsic apoptotic signaling pathway GO:0097191 9.89 TNF TGFB1 FASLG FAS
29 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.89 TNF NLRP3 FASLG FAS CASP1
30 positive regulation of interferon-gamma production GO:0032729 9.88 TNF IL1B IL18
31 negative regulation of T cell proliferation GO:0042130 9.88 TGFB1 SFTPD SCGB1A1 IL10
32 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.87 TNF TGFB1 IL10
33 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.87 HMOX1 FASLG FAS
34 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 TNF IL1B IL1A
35 positive regulation of interleukin-6 secretion GO:2000778 9.87 TNF IL1B IL1A IL17A
36 negative regulation of mitotic cell cycle GO:0045930 9.86 TNF TGFB1 IL10
37 cellular response to lipopolysaccharide GO:0071222 9.86 TNF NLRP3 IL1B IL1A IL10 CXCL8
38 liver regeneration GO:0097421 9.85 TGFB1 IL10 HMOX1
39 positive regulation of cytokine secretion GO:0050715 9.85 TNF IL1A IL10
40 protein kinase B signaling GO:0043491 9.85 TNF TGFB1 IL1B CCL2
41 cellular response to organic cyclic compound GO:0071407 9.85 TNF TGFB1 IL1B IL18 CCL2
42 inflammatory response GO:0006954 9.85 TNF TGFB1 NLRP3 IL1RN IL1B IL1A
43 positive regulation of vascular endothelial growth factor production GO:0010575 9.84 TGFB1 IL1B IL1A
44 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.84 IL4 IL1B IL1A FAS
45 inflammatory response to antigenic stimulus GO:0002437 9.83 IL1RN IL1B IL1A
46 negative regulation of myoblast differentiation GO:0045662 9.82 TNF TGFB1 IL18
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 TNF IL1B IL10
48 positive regulation of neuroinflammatory response GO:0150078 9.78 TNF IL1B IL18
49 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.76 IL4 IL10
50 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.75 IL1RN IL10

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TNFRSF6B TNF TGFB1 SFTPD SCGB1A1 NLRP3
2 cytokine activity GO:0005125 9.4 TNF TGFB1 IL4 IL1RN IL1B IL1A
3 interleukin-1 receptor binding GO:0005149 9.33 IL1RN IL1B IL1A
Sources

Sources for Silicosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
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45 MGI
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50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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