MCID: SLC006
MIFTS: 56

Silicosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

MalaCards integrated aliases for Silicosis:

Name: Silicosis 12 74 52 54 43 15 17 71
Silicotuberculosis 12 71
Chronic Silicosis 52 71
Acute Silicosis 52 71
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 52
Silica Pneumoconiosis 12
Accelerated Silicosis 52

Classifications:



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Disease Ontology 12 DOID:10325
ICD9CM 34 502
MeSH 43 D012829
NCIt 49 C3369
SNOMED-CT 67 805002
ICD10 32 J62 J62.8
UMLS 71 C0037116 C0037118 C0340190 more

Summaries for Silicosis

NIH Rare Diseases : 52 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to anthracosis and pulmonary fibrosis. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Rifapentine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 74 Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. It is... more...

Related Diseases for Silicosis

Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 669)
# Related Disease Score Top Affiliating Genes
1 anthracosis 33.1 TNF TGFB1 NLRP3 CCL2
2 pulmonary fibrosis 31.5 TGFB1 IL1B CXCL8 CCL2
3 idiopathic interstitial pneumonia 31.3 TGFB1 IL4 CXCL8 CCL2
4 bronchitis 31.3 TNF IL4 IL1B IL10 CXCL8
5 bronchopneumonia 30.7 TNF IL10 CXCL8
6 mycobacterium tuberculosis 1 30.7 TNF IL4 IL18 IL17A IL10
7 pulmonary alveolar proteinosis 30.7 TNF IL10 CXCL8 CCL2
8 interstitial lung disease 30.7 TNF TGFB1 IL4 IL1B IL1A IL18
9 bagassosis 30.7 TNF IL1B CXCL8
10 mycobacterium kansasii 30.6 NLRP3 CXCL8
11 systemic scleroderma 30.5 TNF TGFB1 IL4 IL17A ACE
12 pleural disease 30.5 TNF IL1B CXCL8
13 pemphigus 30.5 TNF IL4 IL10 DSG1
14 rheumatic disease 30.4 TNF IL1RN IL1B IL18 IL10
15 histiocytosis 30.4 TNF IL1RN IL17A
16 autoimmune lymphoproliferative syndrome 30.4 TNF IL10 FASLG FAS
17 glomerulonephritis 30.4 TGFB1 SCGB1A1 IL1B CCL2 ACE
18 pulmonary tuberculosis 30.3 TNF IL4 IL18 IL17A IL10 CCL2
19 endocarditis 30.3 TNF IL17A IL10 CXCL8
20 paracoccidioidomycosis 30.3 TNF IL4 IL10
21 pericarditis 30.3 TNF IL1RN IL1B CXCL8 ACE
22 allergic hypersensitivity disease 30.2 TNF IL4 IL17A IL10 CXCL8
23 end stage renal failure 30.2 TNF TGFB1 IL1RN ACE
24 respiratory failure 30.2 TNF SCGB1A1 IL1RN IL1B IL10 CXCL8
25 mycetoma 30.1 IL17A IL10 CXCL8
26 purpura 30.1 TNF IL4 IL10 ACE
27 pulmonary sarcoidosis 30.1 TNF IL18 CCL2 ACE
28 pleurisy 30.1 TNF TGFB1 IL1RN CXCL8 CCL2
29 dysentery 30.1 TNF IL1B IL1A IL10 CXCL8
30 peptic ulcer disease 30.1 TNF IL1RN IL1B IL10 CXCL8
31 bronchiolitis obliterans 30.0 TNF SCGB1A1 IL17A IL10 CXCL8
32 pharyngitis 30.0 TNF NLRP3 IL1RN IL1B CXCL8
33 cryptococcosis 29.9 TNF IL4 IL17A IL10
34 pulmonary hypertension 29.9 TNF IL1B HMOX1 CXCL8 CCL2 ACE
35 aspergillosis 29.9 TNF IL4 IL1RN IL1B IL18 IL10
36 extrapulmonary tuberculosis 29.9 TNF IL1RN IL1B IL10 CCL2
37 sarcoidosis 1 29.9 TNF SCGB1A1 IL1RN IL1B IL1A IL18
38 toxic shock syndrome 29.8 TNF IL4 IL1RN IL1B IL10 CXCL8
39 lymphopenia 29.8 IL4 IL18 IL10 FASLG FAS
40 collagen disease 29.8 TNF IL4 IL17A IL10 ACE
41 bacterial pneumonia 29.8 TNF SCGB1A1 IL17A IL10 CXCL8
42 adult respiratory distress syndrome 29.7 TNF IL1B IL10 CXCL8 ACE
43 synovitis 29.7 TNF IL1RN IL1B IL1A IL18 CXCL8
44 crescentic glomerulonephritis 29.6 TNFRSF6B SCGB1A1 IL1RN CCL2
45 bronchiolitis 29.6 TNF SCGB1A1 IL4 IL17A IL10 CXCL8
46 lymphadenitis 29.5 TNF IL1B IL18 IL10 FASLG FAS
47 lichen planus 29.4 TNF IL4 IL17A IL10 DSG1 CXCL8
48 chronic kidney disease 29.4 TNF TGFB1 IL10 HMOX1 CCL2 ACE
49 kidney disease 29.3 TNF TGFB1 IL18 HMOX1 CCL2 ACE
50 pneumoconiosis 29.2 TNF TGFB1 SCGB1A1 NLRP3 IL4 IL1RN

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):