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MCID: SLF002
MIFTS: 34

Silo Filler's Disease

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Silo Filler's Disease

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MalaCards integrated aliases for Silo Filler's Disease:

Name: Silo Filler's Disease 12 43 15 17 71
Silo-Fillers' Disease 12
Silo Filler Disease 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4374
MeSH 43 D012832
SNOMED-CT 67 61233003
UMLS 71 C0037120
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Summaries for Silo Filler's Disease

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MalaCards based summary : Silo Filler's Disease, also known as silo-fillers' disease, is related to bronchiolitis obliterans and bronchiolitis, and has symptoms including edema An important gene associated with Silo Filler's Disease is LMBR1 (Limb Development Membrane Protein 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, and related phenotypes are growth/size/body region and hematopoietic system

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Related Diseases for Silo Filler's Disease

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Diseases related to Silo Filler's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 30.4 TLR4 TLR2 SFTPD IL17A
2 bronchiolitis 29.8 TLR4 TLR2 SFTPD MUC5AC IL5 IL17A
3 respiratory failure 29.2 TLR4 SFTPD MUC5AC IL5 IL1R1 IL1B
4 farmer's lung 11.9
5 pulmonary edema 10.5
6 fungal keratitis 10.4 TLR4 TLR2
7 gastrointestinal tularemia 10.4 TLR4 TLR2 MYD88
8 superficial basal cell carcinoma 10.4 TLR4 TLR2 MYD88
9 myd88 deficiency 10.4 TLR4 TLR2 MYD88
10 irak4 deficiency 10.4 TLR4 TLR2 MYD88
11 nonspecific interstitial pneumonia 10.4
12 swyer-james syndrome 10.4
13 anogenital venereal wart 10.4 TLR4 TLR2 MYD88
14 filarial elephantiasis 10.3 TLR4 TLR2 IL5
15 invasive aspergillosis 10.3 TLR4 TLR2 SFTPD
16 filariasis 10.3 TLR4 TLR2 IL5
17 mycobacterium abscessus 10.3 TLR2 IFNGR2
18 atopic keratoconjunctivitis 10.2 MUC5AC IL5
19 neisseria meningitidis infection 10.2 TLR4 TLR2 IL1R1
20 neurosyphilis 10.2 TLR2 IL17A
21 paracoccidioidomycosis 10.2 TLR4 TLR2 MYD88 IL5
22 splenic disease 10.2 TLR4 TLR2 MYD88 ITGAX
23 pneumonic plague 10.1 TLR4 TLR2 IL17A
24 norwegian scabies 10.1 IL5 IL17A
25 cystic echinococcosis 10.1 TLR4 TLR2 IL17A
26 status asthmaticus 10.1 MUC5AC IL5 IL1R1
27 mycoplasma pneumoniae pneumonia 10.1 TLR2 SFTPD IL17A
28 ileitis 10.1 TLR4 TLR2 IL17A
29 vogt-koyanagi-harada disease 10.1 TLR4 TLR2 IL17A
30 acute pericementitis 10.0 TLR2 IL1B
31 echinococcosis 10.0 TLR4 TLR2 IL5 IL17A
32 localized pulmonary fibrosis 10.0 SFTPD IL1B
33 keratoconjunctivitis 10.0 MUC5AC IL5 IL17A
34 food allergy 10.0 TLR4 TLR2 IL5 IL17A
35 shwartzman phenomenon 10.0 TLR4 ITGAM
36 granulomatosis with polyangiitis 9.9 TLR4 TLR2 IL5 IL17A
37 hyper ige syndrome 9.9 TLR4 TLR2 IL17A
38 prosthetic joint infection 9.9 TLR4 TLR2 IL1B
39 leukocyte adhesion deficiency, type i 9.9 ITGAX ITGAM IL17A
40 chlamydia pneumonia 9.9 TLR4 TLR2 IL1B
41 suppurative otitis media 9.9 TLR4 TLR2 IL1B
42 dental pulp disease 9.9 TLR4 TLR2 IL1B
43 urethritis 9.9 TLR4 TLR2 IL1B
44 cervicitis 9.9 TLR4 TLR2 IL1B
45 blood group, globoside system 9.9 TLR4 TLR2 IL1B
46 endometrial disease 9.9 TLR4 TLR2 IL1B
47 pyelitis 9.9 TLR4 TLR2 IL1B
48 vaginitis 9.9 TLR4 TLR2 IL1B
49 fallopian tube disease 9.9 TLR4 TLR2 IL1B
50 endometritis 9.9 TLR4 TLR2 IL1B

Graphical network of the top 20 diseases related to Silo Filler's Disease:



Diseases related to Silo Filler's Disease
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Symptoms & Phenotypes for Silo Filler's Disease

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UMLS symptoms related to Silo Filler's Disease:


edema

MGI Mouse Phenotypes related to Silo Filler's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.18 ACTG1 AREG CDON IL17A IL1B IL1R1
2 hematopoietic system MP:0005397 10.13 AREG IFNGR2 IL17A IL1B IL1R1 IL5
3 digestive/alimentary MP:0005381 10.1 ACTG1 AREG CDON IL17A IL1R1 IL5
4 homeostasis/metabolism MP:0005376 10.07 AREG IFNGR2 IL17A IL1B IL1R1 IL5
5 immune system MP:0005387 10 AREG IFNGR2 IL17A IL1B IL1R1 IL5
6 mortality/aging MP:0010768 9.77 ACTG1 AREG CDON IL17A IL1B IL1R1
7 respiratory system MP:0005388 9.23 CDON IL17A IL1R1 IL5 MYD88 SFTPD
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Drugs & Therapeutics for Silo Filler's Disease

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Search Clinical Trials , NIH Clinical Center for Silo Filler's Disease

Cochrane evidence based reviews: silo filler's disease

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Genetic Tests for Silo Filler's Disease

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Anatomical Context for Silo Filler's Disease

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MalaCards organs/tissues related to Silo Filler's Disease:

40
Lung
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Publications for Silo Filler's Disease

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Articles related to Silo Filler's Disease:

(show all 42)
# Title Authors PMID Year
1
Ultraviolet Photoactivated Room Temperature NO2 Gas Sensor of ZnO Hemitubes and Nanotubes Covered with TiO2 Nanoparticles. 61
32143528 2020
2
Silo-Filler's Disease: One Health System's Experience and an Update of the Literature. 61
30879430 2020
3
Nitrogen dioxide (silo gas) poisoning in dairy cattle. 61
17990632 2007
4
Silo-Filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. 61
15353441 2004
5
[Respiratory pathology in the agricultural environment]. 61
9781190 1998
6
Lung (agricultural/rural). 61
8637735 1996
7
Case of the season. Silo filler's disease in a patient with prior Swyer-James syndrome. 61
8272877 1993
8
Silo filler's disease in New York State. 61
1519842 1992
9
Hazardous exposure and lung disease among farm workers. 61
1511556 1992
10
[Acute dyspnea, cough, headache]. 61
2020781 1991
11
The Bassett Farm Safety and Health Project. 61
2248240 1990
12
[A case of silo-fillers' disease]. 61
2615101 1989
13
Silo-filler's disease. 61
2704252 1989
14
Silo-filler's disease: a new perspective. 61
2704256 1989
15
Silo-filler's disease. A historical perspective and report of a case. 61
3904234 1985
16
Silo filler's disease. 61
6433237 1984
17
Feed-associated respiratory illness in farmers. 61
6712283 1984
18
Silo-Filler's disease in rural New York. 61
6813669 1982
19
Silo-filler's disease. 61
688149 1978
20
Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the leterature. 61
627925 1978
21
Lung disease in farmers. 61
321110 1977
22
Silo-Filler's disease. 61
1118673 1975
23
Silo filler's disease. 61
4703623 1973
24
Silo Filler's disease. 61
5048897 1972
25
[Poisoning caused by nitrous fumes during ensilage. Silo-filler's disease]. 61
5022614 1972
26
[Silo filler's disease]. 61
5111139 1971
27
Silo-filler's disease: nitrogen dioxide-induced lung injury. Long-term follow-up and review of the literature. 61
5573158 1971
28
[Silo filler's disease]. 61
5973378 1966
29
FARMER'S LUNG AND SILO-FILLER'S DISEASE. 61
14148161 1964
30
OCCURRENCE OF SILO FILLERS' DISEASE IN CHILDREN. 61
14149005 1964
31
"SILO FILLER'S DISEASE" IN DAIRY CATTLE. 61
14077958 1963
32
Silo fillers disease. 61
13990229 1963
33
[Silo-filler's disease. Clinical contribution]. 61
13948081 1963
34
Silo Filler's disease. Relapse following latent period. 61
14489845 1961
35
Silo-filler's disease: report of two cases in Henderson County, North Carolina. 61
13820978 1960
36
Silo-filler's disease. 61
13812011 1960
37
Chronic silo filler's disease. 61
13597567 1958
38
Chronic pulmonary insufficiency secondary to silo-filler's disease. 61
13520747 1958
39
Silo-fillers disease; report of a case. 61
13517515 1958
40
Silo-filler's disease; a syndrome caused by nitrogen dioxide. 61
13357306 1956
41
Silo-Filler's Disease. 61
20325316 1956
42
Silo-filler's disease. 61
13310596 1956
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Variations for Silo Filler's Disease

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Expression for Silo Filler's Disease

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Search GEO for disease gene expression data for Silo Filler's Disease.
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Pathways for Silo Filler's Disease

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Pathways related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.03 TLR4 TLR2 MYD88 MUC5AC ITGAX ITGAM
2
ERK Signaling 63
Show member pathways
 13.82 ITGAX ITGAM IL5 IL1R1 IL1B IL17A
3
TGF-Beta Pathway 63
Show member pathways
 13.56 ITGAX ITGAM IL5 IL1R1 IL1B IL17A
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.37 MYD88 ITGAX ITGAM IL5 IL1R1 IL1B
5
PAK Pathway 63
Show member pathways
 13.3 IL5 IL1R1 IL1B IL17A CCL20 AREG
6
IL-2 Pathway 63
Show member pathways
 13.22 TLR4 TLR2 MYD88 IL1R1 IL1B IFNGR2
7
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.05 TLR4 TLR2 SFTPD MYD88 IL1B IFNGR2
8
Akt Signaling 63
Show member pathways
 12.88 TLR4 TLR2 MYD88 ITGAX ITGAM IL5
9
Measles 36
Show member pathways
 12.84 TLR4 TLR2 MYD88 IL1B IFNGR2 ACTG1
10
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.75 TLR4 TLR2 MYD88 MUC5AC IL1R1 IL1B
11
NF-KappaB Family Pathway 63
Show member pathways
 12.73 TLR4 TLR2 MYD88 IL1R1 IL1B AREG
12
TRAF Pathway 63
Show member pathways
 12.6 TLR4 TLR2 MYD88 IL1R1 IL1B
13
T cell receptor signaling pathway 36
Show member pathways
 12.56 TLR4 TLR2 MYD88 IL5 IL1B IL17A
14
Th17 cell differentiation 36
Show member pathways
 12.54 TLR4 TLR2 IL5 IL1R1 IL1B IL17A
15
Shigellosis 36
12.42 TLR4 MYD88 IL1R1 IL1B ACTG1
16
IL-17 Family Signaling Pathways 64
Show member pathways
 12.37 TLR2 MUC5AC IL5 IL1B IL17A CCL20
17
Toll Comparative Pathway 63
Show member pathways
 12.35 TLR4 MYD88 IL1R1 IL1B IFNGR2
18
Salmonella infection (KEGG) 36
12.33 TLR4 TLR2 MYD88 IL1B ACTG1
19
Pathogenic Escherichia coli infection 36
12.29 TLR4 MYD88 IL1R1 IL1B ACTG1
20
Toxoplasmosis 36
Show member pathways
 12.25 TLR4 TLR2 MYD88 ITGAM IL1B IFNGR2
21
MAPK Pathway 70
Show member pathways
 12.08 TLR4 TLR2 IL5 IL1R1 IL1B
22
Yersinia infection 36
12.05 TLR4 MYD88 IL1B ACTG1
23
Phagosome 36
12.03 TLR4 TLR2 SFTPD MSR1 ITGAM ACTG1
24
Interleukin-4 and 13 signaling 65
12.02 ITGAX ITGAM IL1B IL17A
25
IL27-mediated signaling events 1
Show member pathways
 12 TLR4 TLR2 IL1B IL17A IFNGR2
26
NF-kappa B signaling pathway 36
11.97 TLR4 MYD88 IL1R1 IL1B
27
Amoebiasis 36
11.97 TLR4 TLR2 ITGAM IL1R1 IL1B
28
Tuberculosis 36
11.96 TLR4 TLR2 MYD88 ITGAX ITGAM IL1B
29
Hematopoietic cell lineage 36
11.94 ITGAM IL5 IL1R1 IL1B
30
Rheumatoid arthritis 36
11.9 TLR4 TLR2 IL1B IL17A CCL20
31
Th17 Differentiation 64
Show member pathways
 11.88 TLR4 TLR2 IL1R1 IL1B IL17A
32
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.84 TLR4 MYD88 IL17A
33
Phagocytosis of Microbes 63
11.84 TLR4 TLR2 MSR1 ITGAX ITGAM
34
Pertussis 36
11.8 TLR4 MYD88 ITGAM IL1B
35
Dendritic Cells Developmental Lineage Pathway 64
11.74 ITGAX ITGAM IL1B
36
Innate Lymphoid Cells Differentiation 64
11.71 ITGAM IL5 IL1R1 IL1B IL17A
37
Agrin Interactions at Neuromuscular Junction 63
11.61 ITGAX ITGAM ACTG1
38
Transcription_NF-kB signaling pathway 22
11.59 TLR4 MYD88 IL1R1
39
Malaria 36
11.59 TLR4 TLR2 MYD88 IL1B
40
Interleukin-10 signaling 65
11.54 IL1R1 IL1B CCL20
41
Legionellosis 36
11.48 TLR4 TLR2 MYD88 ITGAM IL1B
42
Bacterial infections in CF airways 22
Show member pathways
 11.44 TLR4 TLR2 SFTPD MYD88 IL1R1 IL1B
43
Development and heterogeneity of the ILC family 1
11.35 IL5 IL1B IL17A AREG
44
MSP-RON Signaling 63
11.34 TLR4 TLR2 ITGAM IL1B ACTG1
45
IL1 and megakaryocytes in obesity 1
11.13 TLR2 MYD88 IL1R1 IL1B
46
G-protein signaling_Rap2B regulation pathway 22
11.05 ITGAX ITGAM IL5 IL1B IL17A CCL20
47
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.78 IL5 IL1B
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GO Terms for Silo Filler's Disease

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Cellular components related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 TLR4 TLR2 MSR1 LMBR1 IL1R1 IFNGR2
2 cell surface GO:0009986 9.63 TLR4 TLR2 ITGAX ITGAM IL1R1 AREG
3 external side of plasma membrane GO:0009897 9.43 TLR4 MSR1 ITGAX ITGAM IL1R1 IL17A
4 low-density lipoprotein particle GO:0034362 9.32 MSR1 LSR
5 extracellular space GO:0005615 9.32 SFTPD POTEF MUC5AC ITGAM IL5 IL1B

Biological processes related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.26 TLR4 TLR2 MYD88 LMBR1 IL5 IL1R1
2 positive regulation of gene expression GO:0010628 10 TLR4 TLR2 MYD88 ITGAX IL1B ACTG1
3 defense response to bacterium GO:0042742 9.96 TLR4 SFTPD MYD88 CCL20
4 immune response GO:0006955 9.95 TLR4 TLR2 IL5 IL1R1 IL1B IL17A
5 cell-cell signaling GO:0007267 9.94 IL1B IL17A CCL20 AREG
6 response to lipopolysaccharide GO:0032496 9.9 TLR4 TLR2 MYD88 IL1B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TLR4 TLR2 MYD88 IL1B
8 interleukin-1-mediated signaling pathway GO:0070498 9.85 MYD88 IL1R1 IL1B
9 positive regulation of inflammatory response GO:0050729 9.85 TLR4 TLR2 IL1B
10 regulation of inflammatory response GO:0050727 9.84 TLR4 MYD88 IL1R1
11 positive regulation of JNK cascade GO:0046330 9.82 TLR4 MYD88 IL1B
12 cellular response to mechanical stimulus GO:0071260 9.81 TLR4 MYD88 IL1B
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 TLR4 TLR2 IL1B
14 positive regulation of tumor necrosis factor production GO:0032760 9.79 TLR4 TLR2 MYD88
15 cellular response to interferon-gamma GO:0071346 9.78 TLR4 TLR2 CCL20 ACTG1
16 positive regulation of interferon-gamma production GO:0032729 9.74 TLR4 IL1R1 IL1B
17 response to interleukin-1 GO:0070555 9.73 MYD88 IL1R1 IL1B
18 positive regulation of interleukin-6 production GO:0032755 9.73 TLR4 TLR2 MYD88 IL1B
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.72 TLR4 TLR2 MYD88
20 microglial cell activation GO:0001774 9.71 TLR2 ITGAM IFNGR2
21 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR4 TLR2
22 amyloid-beta clearance GO:0097242 9.68 MSR1 ITGAM
23 positive regulation of keratinocyte proliferation GO:0010838 9.67 TLR4 AREG
24 toll-like receptor signaling pathway GO:0002224 9.67 TLR4 TLR2 SFTPD MYD88
25 positive regulation of chemokine biosynthetic process GO:0045080 9.66 MYD88 IL1B
26 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.65 TLR4 MYD88
27 I-kappaB phosphorylation GO:0007252 9.65 TLR4 TLR2
28 cellular response to lipoteichoic acid GO:0071223 9.63 TLR4 TLR2
29 positive regulation of lymphocyte proliferation GO:0050671 9.63 TLR4 MYD88
30 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.63 TLR4 MYD88 IL17A
31 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.62 TLR4 IL17A
32 positive regulation of interleukin-6 secretion GO:2000778 9.62 TLR4 TLR2 IL1B IL17A
33 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.59 IL1R1 IL1B
34 positive regulation of interleukin-23 production GO:0032747 9.58 MYD88 IL17A
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 TLR4 TLR2 MYD88 IL1B
36 inflammatory response GO:0006954 9.56 TLR4 TLR2 MYD88 IL5 IL1R1 IL1B
37 positive regulation of matrix metallopeptidase secretion GO:1904466 9.51 TLR4 TLR2
38 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.49 TLR4 TLR2
39 positive regulation of interleukin-8 production GO:0032757 9.46 TLR4 TLR2 MYD88 IL1B
40 cytokine-mediated signaling pathway GO:0019221 9.28 MYD88 ITGAX ITGAM IL5 IL1R1 IL1B

Molecular functions related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 TLR4 TLR2 SFTPD POTEF MYD88 MUC5AC
2 cytokine activity GO:0005125 9.65 IL5 IL1B IL17A CCL20 AREG
3 lipopolysaccharide binding GO:0001530 9.5 TLR4 TLR2 SFTPD
4 interleukin-1 receptor binding GO:0005149 9.48 MYD88 IL1B
5 cargo receptor activity GO:0038024 9.46 MSR1 ITGAM
6 amyloid-beta binding GO:0001540 9.46 TLR4 TLR2 MSR1 ITGAM
7 Toll-like receptor binding GO:0035325 9.4 TLR2 MYD88
8 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
9 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.13 TLR4 TLR2 IL1R1
10 NAD(P)+ nucleosidase activity GO:0050135 8.8 TLR4 TLR2 IL1R1
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Sources for Silo Filler's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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