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MCID: SLF002
MIFTS: 33

Silo Filler's Disease

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Silo Filler's Disease

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MalaCards integrated aliases for Silo Filler's Disease:

Name: Silo Filler's Disease 12 43 15 17 71
Silo-Fillers' Disease 12
Silo Filler Disease 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4374
MeSH 43 D012832
SNOMED-CT 67 61233003
UMLS 71 C0037120
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Summaries for Silo Filler's Disease

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MalaCards based summary : Silo Filler's Disease, also known as silo-fillers' disease, is related to bronchiolitis obliterans and respiratory failure, and has symptoms including edema An important gene associated with Silo Filler's Disease is LMBR1 (Limb Development Membrane Protein 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, and related phenotypes are growth/size/body region and digestive/alimentary

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Related Diseases for Silo Filler's Disease

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Diseases related to Silo Filler's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 30.4 TLR4 SFTPD IL17A
2 respiratory failure 30.3 SFTPD MUC5AC IL5 IL1R1
3 bronchiolitis 29.7 TLR4 TLR2 SFTPD MUC5AC IL5 IL17A
4 farmer's lung 11.9
5 pulmonary edema 10.5
6 prosthetic joint infection 10.5 TLR4 TLR2
7 fungal keratitis 10.4 TLR4 TLR2
8 gastrointestinal tularemia 10.4 TLR4 TLR2 MYD88
9 superficial basal cell carcinoma 10.4 TLR4 TLR2 MYD88
10 myd88 deficiency 10.4 TLR4 TLR2 MYD88
11 irak4 deficiency 10.4 TLR4 TLR2 MYD88
12 anogenital venereal wart 10.4 TLR4 TLR2 MYD88
13 nonspecific interstitial pneumonia 10.3
14 swyer-james syndrome 10.3
15 filarial elephantiasis 10.3 TLR4 TLR2 IL5
16 q fever 10.3 TLR4 TLR2 MYD88
17 bacterial sepsis 10.3 TLR4 TLR2 MYD88
18 hydrops, lactic acidosis, and sideroblastic anemia 10.3
19 aphthous stomatitis 10.3 TLR4 TLR2 IL5
20 atopic keratoconjunctivitis 10.3 MUC5AC IL5
21 invasive aspergillosis 10.3 TLR4 TLR2 SFTPD
22 neisseria meningitidis infection 10.3 TLR4 TLR2 IL1R1
23 filariasis 10.3 TLR4 TLR2 IL5
24 middle ear disease 10.2 TLR4 TLR2 MUC5AC
25 paracoccidioidomycosis 10.2 TLR4 TLR2 MYD88 IL5
26 status asthmaticus 10.2 MUC5AC IL5 IL1R1
27 spondylarthropathy 10.1 TLR4 TLR2
28 neurosyphilis 10.1 TLR2 IL17A
29 lymphoma, mucosa-associated lymphoid type 10.1 TLR4 TLR2 MYD88
30 toxic shock syndrome 10.1 TLR4 TLR2 IL1R1
31 indolent myeloma 10.1 IL1R1 CASP1
32 norwegian scabies 10.1 IL5 IL17A
33 bronchitis 10.1 TLR4 TLR2 IL5
34 pneumonic plague 10.1 TLR4 TLR2 IL17A
35 candidiasis 10.0 TLR4 TLR2 IL17A
36 trypanosomiasis 10.0 TLR4 TLR2 MYD88
37 primary systemic mycosis 10.0 TLR4 TLR2 IL17A
38 metal allergy 10.0 TLR4 IL17A
39 gout 10.0 TLR4 TLR2 IL1R1
40 cystic echinococcosis 10.0 TLR4 TLR2 IL17A
41 amebiasis 10.0 TLR4 TLR2 IL17A
42 gingival disease 10.0 TLR4 TLR2 IL17A
43 splenic disease 10.0 TLR4 TLR2 IL17A
44 vaginal disease 10.0 TLR4 TLR2 IL17A
45 scrub typhus 10.0 TLR4 TLR2 IL17A
46 rectal disease 10.0 TLR4 TLR2 IL17A
47 mycoplasma pneumoniae pneumonia 10.0 TLR2 SFTPD IL17A
48 osteomyelitis 10.0 TLR4 TLR2 CASP1
49 aggressive periodontitis 10.0 TLR4 TLR2 IL17A
50 periodontitis 10.0 TLR4 TLR2 IL17A

Graphical network of the top 20 diseases related to Silo Filler's Disease:



Diseases related to Silo Filler's Disease
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Symptoms & Phenotypes for Silo Filler's Disease

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UMLS symptoms related to Silo Filler's Disease:


edema

MGI Mouse Phenotypes related to Silo Filler's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 ACTG1 AREG CDON IL17A IL1R1 IL5
2 digestive/alimentary MP:0005381 10.07 ACTG1 AREG CASP1 CDON IL17A IL5
3 hematopoietic system MP:0005397 10.03 AREG CASP1 IL17A IL1R1 IL5 ITGAM
4 immune system MP:0005387 9.97 AREG CASP1 IL17A IL1R1 IL5 ITGAM
5 mortality/aging MP:0010768 9.77 ACTG1 AREG CASP1 CDON IL17A IL1R1
6 respiratory system MP:0005388 9.23 CDON IL17A IL1R1 IL5 MYD88 SFTPD
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Drugs & Therapeutics for Silo Filler's Disease

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Search Clinical Trials , NIH Clinical Center for Silo Filler's Disease

Cochrane evidence based reviews: silo filler's disease

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Genetic Tests for Silo Filler's Disease

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Anatomical Context for Silo Filler's Disease

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MalaCards organs/tissues related to Silo Filler's Disease:

40
Lung
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Publications for Silo Filler's Disease

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Articles related to Silo Filler's Disease:

(show all 41)
# Title Authors PMID Year
1
Silo-Filler's Disease: One Health System's Experience and an Update of the Literature. 61
30879430 2019
2
Nitrogen dioxide (silo gas) poisoning in dairy cattle. 61
17990632 2007
3
Silo-Filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. 61
15353441 2004
4
[Respiratory pathology in the agricultural environment]. 61
9781190 1998
5
Lung (agricultural/rural). 61
8637735 1996
6
Case of the season. Silo filler's disease in a patient with prior Swyer-James syndrome. 61
8272877 1993
7
Silo filler's disease in New York State. 61
1519842 1992
8
Hazardous exposure and lung disease among farm workers. 61
1511556 1992
9
[Acute dyspnea, cough, headache]. 61
2020781 1991
10
The Bassett Farm Safety and Health Project. 61
2248240 1990
11
[A case of silo-fillers' disease]. 61
2615101 1989
12
Silo-filler's disease. 61
2704252 1989
13
Silo-filler's disease: a new perspective. 61
2704256 1989
14
Silo-filler's disease. A historical perspective and report of a case. 61
3904234 1985
15
Silo filler's disease. 61
6433237 1984
16
Feed-associated respiratory illness in farmers. 61
6712283 1984
17
Silo-Filler's disease in rural New York. 61
6813669 1982
18
Silo-filler's disease. 61
688149 1978
19
Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the leterature. 61
627925 1978
20
Lung disease in farmers. 61
321110 1977
21
Silo-Filler's disease. 61
1118673 1975
22
Silo filler's disease. 61
4703623 1973
23
Silo Filler's disease. 61
5048897 1972
24
[Poisoning caused by nitrous fumes during ensilage. Silo-filler's disease]. 61
5022614 1972
25
[Silo filler's disease]. 61
5111139 1971
26
Silo-filler's disease: nitrogen dioxide-induced lung injury. Long-term follow-up and review of the literature. 61
5573158 1971
27
[Silo filler's disease]. 61
5973378 1966
28
FARMER'S LUNG AND SILO-FILLER'S DISEASE. 61
14148161 1964
29
OCCURRENCE OF SILO FILLERS' DISEASE IN CHILDREN. 61
14149005 1964
30
"SILO FILLER'S DISEASE" IN DAIRY CATTLE. 61
14077958 1963
31
Silo fillers disease. 61
13990229 1963
32
[Silo-filler's disease. Clinical contribution]. 61
13948081 1963
33
Silo Filler's disease. Relapse following latent period. 61
14489845 1961
34
Silo-filler's disease: report of two cases in Henderson County, North Carolina. 61
13820978 1960
35
Silo-filler's disease. 61
13812011 1960
36
Chronic silo filler's disease. 61
13597567 1958
37
Chronic pulmonary insufficiency secondary to silo-filler's disease. 61
13520747 1958
38
Silo-fillers disease; report of a case. 61
13517515 1958
39
Silo-filler's disease; a syndrome caused by nitrogen dioxide. 61
13357306 1956
40
Silo-Filler's Disease. 61
20325316 1956
41
Silo-filler's disease. 61
13310596 1956
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Variations for Silo Filler's Disease

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Expression for Silo Filler's Disease

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Search GEO for disease gene expression data for Silo Filler's Disease.
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Pathways for Silo Filler's Disease

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Pathways related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.98 TLR4 TLR2 MYD88 MUC5AC ITGAX ITGAM
2
ERK Signaling 63
Show member pathways
 13.81 ITGAX ITGAM IL5 IL1R1 IL17A CXCL1
3
PAK Pathway 63
Show member pathways
 13.28 IL5 IL1R1 IL17A CXCL1 CCL20 CASP1
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.27 MYD88 ITGAX ITGAM IL5 IL1R1 IL17A
5
Akt Signaling 63
Show member pathways
 12.88 TLR4 TLR2 MYD88 ITGAX ITGAM IL5
6
Measles 36
Show member pathways
 12.79 TLR4 TLR2 MYD88 CASP1 ACTG1
7
NF-KappaB Family Pathway 63
Show member pathways
 12.7 TLR4 TLR2 MYD88 IL1R1 AREG
8
T cell receptor signaling pathway 36
Show member pathways
 12.59 TLR4 TLR2 MYD88 IL5 IL17A
9
Th17 cell differentiation 36
Show member pathways
 12.59 TLR4 TLR2 IL5 IL1R1 IL17A
10
TRAF Pathway 63
Show member pathways
 12.57 TLR4 TLR2 MYD88 IL1R1 CASP1
11
Shigellosis 36
12.36 TLR4 MYD88 IL1R1 CASP1 ACTG1
12
Toxoplasmosis 36
Show member pathways
 12.26 TLR4 TLR2 MYD88 ITGAM
13
Pathogenic Escherichia coli infection 36
12.26 TLR4 MYD88 IL1R1 CASP1 ACTG1
14
IL-17 Family Signaling Pathways 64
Show member pathways
 12.24 TLR2 MUC5AC IL5 IL17A CXCL1 CCL20
15
NOD-like receptor signaling pathway 36
12.23 TLR4 MYD88 CXCL1 CASP1
16
IL-1 Family Signaling Pathways 64
Show member pathways
 12.21 TLR2 MYD88 MUC5AC IL1R1
17
Tuberculosis 36
12.18 TLR4 TLR2 MYD88 ITGAX ITGAM
18
Th1 Differentiation Pathway 64
Show member pathways
 12.05 TLR4 TLR2 IL1R1 IL17A
19
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.03 TLR4 TLR2 MSR1 ITGAM
20
MAPK Pathway 70
Show member pathways
 12.02 TLR4 TLR2 IL5 IL1R1
21
Yersinia infection 36
12 TLR4 MYD88 CASP1 ACTG1
22
Reelin Pathway (Cajal-Retzius cells) 63
11.95 ITGAX ITGAM CASP1 ACTG1
23
Bacterial infections in CF airways 22
Show member pathways
 11.95 TLR4 TLR2 SFTPD MYD88 IL1R1 CCL20
24
NF-kappa B signaling pathway 36
11.91 TLR4 MYD88 IL1R1 CXCL1
25
Hematopoietic cell lineage 36
11.86 ITGAM IL5 IL1R1
26
Amoebiasis 36
11.86 TLR4 TLR2 ITGAM IL1R1 CXCL1
27
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.85 TLR4 MYD88 IL17A CXCL1
28
Phagosome 36
11.81 TLR4 TLR2 SFTPD MSR1 ITGAM ACTG1
29
Innate Lymphoid Cell Differentiation Pathways 64
11.77 ITGAM IL5 IL1R1 IL17A
30
Rheumatoid arthritis 36
11.77 TLR4 TLR2 IL17A CXCL1 CCL20
31
Pertussis 36
11.73 TLR4 MYD88 ITGAM CASP1
32
Phagocytosis of Microbes 63
11.7 TLR4 TLR2 MSR1 ITGAX ITGAM
33
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.69 MSR1 IL17A CXCL1 CCL20
34
Salmonella infection (KEGG) 36
11.62 TLR4 MYD88 CXCL1 CASP1 ACTG1
35
Agrin Interactions at Neuromuscular Junction 63
11.61 ITGAX ITGAM ACTG1
36
Transcription_NF-kB signaling pathway 22
11.58 TLR4 MYD88 IL1R1
37
Malaria 36
11.54 TLR4 TLR2 MYD88
38
Interleukin-10 signaling 65
11.52 IL1R1 CXCL1 CCL20
39
MSP-RON Signaling 63
11.46 TLR4 TLR2 ITGAM ACTG1
40
Development and heterogeneity of the ILC family 1
11.3 IL5 IL17A AREG
41
IL1 and megakaryocytes in obesity 1
11.17 TLR2 MYD88 IL1R1
42
G-protein signaling_Rap2B regulation pathway 22
10.94 ITGAX ITGAM IL5 IL17A CXCL1 CCL20
43
Legionellosis 36
10.86 TLR4 TLR2 MYD88 ITGAM CXCL1 CASP1
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GO Terms for Silo Filler's Disease

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Cellular components related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 TLR4 ITGAX ITGAM IL1R1 IL17A
2 cell surface GO:0009986 9.43 TLR4 TLR2 ITGAX ITGAM IL1R1 AREG
3 extracellular space GO:0005615 9.32 SFTPD POTEF MUC5AC ITGAM IL5 IL17A
4 low-density lipoprotein particle GO:0034362 9.26 MSR1 LSR

Biological processes related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.19 TLR4 TLR2 MYD88 IL5 IL1R1 CXCL1
2 innate immune response GO:0045087 10.01 TLR4 TLR2 SFTPD MYD88 ITGAM
3 defense response to bacterium GO:0042742 9.91 TLR4 SFTPD MYD88 CCL20
4 immune response GO:0006955 9.87 TLR4 TLR2 IL5 IL1R1 IL17A CXCL1
5 cellular response to lipopolysaccharide GO:0071222 9.85 TLR4 MYD88 CXCL1 CASP1
6 cellular response to mechanical stimulus GO:0071260 9.76 TLR4 MYD88 CASP1
7 apoptotic signaling pathway GO:0097190 9.74 TLR4 ITGAM CASP1
8 positive regulation of interleukin-6 production GO:0032755 9.73 TLR4 TLR2 MYD88
9 positive regulation of interleukin-6 secretion GO:2000778 9.69 TLR4 TLR2 IL17A
10 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR4 TLR2 MYD88
11 regulation of inflammatory response GO:0050727 9.67 TLR4 MYD88 IL1R1 CASP1
12 positive regulation of interleukin-8 production GO:0032757 9.65 TLR4 TLR2 MYD88
13 positive regulation of interleukin-8 secretion GO:2000484 9.63 TLR4 TLR2
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR4 TLR2
15 amyloid-beta clearance GO:0097242 9.62 MSR1 ITGAM
16 positive regulation of keratinocyte proliferation GO:0010838 9.62 TLR4 AREG
17 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.6 TLR4 MYD88
18 I-kappaB phosphorylation GO:0007252 9.59 TLR4 TLR2
19 cellular response to lipoteichoic acid GO:0071223 9.58 TLR4 TLR2
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TLR4 MYD88 IL17A
21 toll-like receptor signaling pathway GO:0002224 9.56 TLR4 TLR2 SFTPD MYD88
22 inflammatory response GO:0006954 9.56 TLR4 TLR2 MYD88 IL5 IL1R1 IL17A
23 cellular response to interferon-gamma GO:0071346 9.55 TLR4 TLR2 CCL20 CASP1 ACTG1
24 positive regulation of interleukin-23 production GO:0032747 9.52 MYD88 IL17A
25 positive regulation of matrix metallopeptidase secretion GO:1904466 9.46 TLR4 TLR2
26 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.43 TLR4 TLR2
27 cytokine-mediated signaling pathway GO:0019221 9.23 ITGAX ITGAM IL5 IL1R1 IL17A CXCL1

Molecular functions related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.33 TLR4 TLR2 SFTPD POTEF MYD88 MUC5AC
2 cargo receptor activity GO:0038024 9.37 MSR1 ITGAM
3 cytokine activity GO:0005125 9.35 IL5 IL17A CXCL1 CCL20 AREG
4 lipopolysaccharide binding GO:0001530 9.33 TLR4 TLR2 SFTPD
5 Toll-like receptor binding GO:0035325 9.32 TLR2 MYD88
6 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
7 amyloid-beta binding GO:0001540 8.92 TLR4 TLR2 MSR1 ITGAM
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Sources for Silo Filler's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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