MCID: SLF002
MIFTS: 35

Silo Filler's Disease

Categories: Respiratory diseases

Aliases & Classifications for Silo Filler's Disease

MalaCards integrated aliases for Silo Filler's Disease:

Name: Silo Filler's Disease 12 44 15 17 71
Silo-Fillers' Disease 12
Silo Filler Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4374
MeSH 44 D012832
SNOMED-CT 67 61233003
UMLS 71 C0037120

Summaries for Silo Filler's Disease

Disease Ontology : 12 A lung disease that is characterized by inhalation of nitrogen oxides from exposure to silage gas in recently filled silos resulting in sudden death, pulmonary edema, and/or bronchiolitis obliterans.

MalaCards based summary : Silo Filler's Disease, also known as silo-fillers' disease, is related to bronchiolitis obliterans and adult respiratory distress syndrome, and has symptoms including edema An important gene associated with Silo Filler's Disease is MYD88 (MYD88 Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Silo Filler's Disease

Diseases related to Silo Filler's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 30.4 TLR4 SFTPD IL17A
2 adult respiratory distress syndrome 29.5 SFTPD ITGAM IL1R1 IL1B
3 bronchiolitis 29.4 TLR4 TLR2 SFTPD IL5 IL1B IL17A
4 farmer's lung 11.3
5 pulmonary edema 10.4
6 endometrial mixed adenocarcinoma 10.3 TLR2 MYD88
7 fungal keratitis 10.3 TLR4 TLR2
8 mycobacterium abscessus 10.3 TLR2 IFNGR2
9 glanders 10.3 TLR4 MYD88
10 chronic purulent otitis media 10.3 TLR4 TLR2
11 superficial basal cell carcinoma 10.3 TLR4 TLR2 MYD88
12 gastrointestinal tularemia 10.3 TLR4 TLR2 MYD88
13 filarial elephantiasis 10.3 TLR4 TLR2 IL5
14 atopic keratoconjunctivitis 10.3 MUC5AC IL5
15 filariasis 10.2 TLR4 TLR2 IL5
16 human monocytic ehrlichiosis 10.2 TLR2 MYD88
17 invasive aspergillosis 10.2 TLR4 TLR2 SFTPD
18 nonspecific interstitial pneumonia 10.2
19 swyer-james syndrome 10.2
20 chromium allergic contact dermatitis 10.2 IL5 IL17A
21 neurosyphilis 10.2 TLR2 IL17A
22 lymphoma, mucosa-associated lymphoid type 10.2 TLR4 TLR2 MYD88
23 norwegian scabies 10.2 IL5 IL17A
24 metal allergy 10.2 TLR4 IL17A
25 paracoccidioidomycosis 10.2 TLR4 TLR2 MYD88 IL5
26 granulomatosis with polyangiitis 10.2 TLR4 TLR2 IL5
27 hereditary angioedema with normal c1inh 10.1 TLR4 TLR2
28 pneumonic plague 10.1 TLR4 TLR2 IL17A
29 cystic echinococcosis 10.1 TLR4 TLR2 IL17A
30 ileitis 10.1 TLR4 TLR2 IL17A
31 mycoplasma pneumoniae pneumonia 10.1 TLR2 SFTPD IL17A
32 trichinosis 10.1 IL5 IL17A
33 neisseria meningitidis infection 10.1 TLR4 TLR2 IL1R1
34 hyper ige syndrome 10.0 TLR4 TLR2 IL17A
35 localized pulmonary fibrosis 10.0 SFTPD IL1B
36 anaerobic pneumonia 10.0 TLR2 IL1B
37 keratoconjunctivitis 10.0 MUC5AC IL5 IL17A
38 echinococcosis 10.0 TLR4 TLR2 IL5 IL17A
39 food allergy 10.0 TLR4 TLR2 IL5 IL17A
40 status asthmaticus 10.0 MUC5AC IL5 IL1R1
41 prosthetic joint infection 10.0 TLR4 TLR2 IL1B
42 congenital cytomegalovirus 10.0 TLR4 TLR2 IL1B
43 pemphigoid 10.0 IL5 IL1B
44 dental pulp disease 9.9 TLR4 TLR2 IL1B
45 suppurative otitis media 9.9 TLR4 TLR2 IL1B
46 chlamydia pneumonia 9.9 TLR4 TLR2 IL1B
47 urethritis 9.9 TLR4 TLR2 IL1B
48 pyelitis 9.9 TLR4 TLR2 IL1B
49 fallopian tube disease 9.9 TLR4 TLR2 IL1B
50 endometrial disease 9.9 TLR4 TLR2 IL1B

Graphical network of the top 20 diseases related to Silo Filler's Disease:



Diseases related to Silo Filler's Disease

Symptoms & Phenotypes for Silo Filler's Disease

UMLS symptoms related to Silo Filler's Disease:


edema

MGI Mouse Phenotypes related to Silo Filler's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 AREG IFNGR2 IL17A IL1B IL1R1 IL5
2 homeostasis/metabolism MP:0005376 10.1 AREG CCL20 IFNGR2 IL17A IL1B IL1R1
3 digestive/alimentary MP:0005381 10.02 ACTG1 AREG IL17A IL1R1 IL5 MUC5AC
4 immune system MP:0005387 10 AREG IFNGR2 IL17A IL1B IL1R1 IL5
5 neoplasm MP:0002006 9.43 IL1B IL1R1 IL5 MYD88 TLR2 TLR4
6 respiratory system MP:0005388 9.17 IL17A IL1R1 IL5 MYD88 SFTPD TLR2

Drugs & Therapeutics for Silo Filler's Disease

Search Clinical Trials , NIH Clinical Center for Silo Filler's Disease

Cochrane evidence based reviews: silo filler's disease

Genetic Tests for Silo Filler's Disease

Anatomical Context for Silo Filler's Disease

Publications for Silo Filler's Disease

Articles related to Silo Filler's Disease:

(show all 42)
# Title Authors PMID Year
1
Ultraviolet Photoactivated Room Temperature NO2 Gas Sensor of ZnO Hemitubes and Nanotubes Covered with TiO2 Nanoparticles. 61
32143528 2020
2
Silo-Filler's Disease: One Health System's Experience and an Update of the Literature. 61
30879430 2020
3
Nitrogen dioxide (silo gas) poisoning in dairy cattle. 61
17990632 2007
4
Silo-Filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. 61
15353441 2004
5
[Respiratory pathology in the agricultural environment]. 61
9781190 1998
6
Lung (agricultural/rural). 61
8637735 1996
7
Case of the season. Silo filler's disease in a patient with prior Swyer-James syndrome. 61
8272877 1993
8
Silo filler's disease in New York State. 61
1519842 1992
9
Hazardous exposure and lung disease among farm workers. 61
1511556 1992
10
[Acute dyspnea, cough, headache]. 61
2020781 1991
11
The Bassett Farm Safety and Health Project. 61
2248240 1990
12
[A case of silo-fillers' disease]. 61
2615101 1989
13
Silo-filler's disease. 61
2704252 1989
14
Silo-filler's disease: a new perspective. 61
2704256 1989
15
Silo-filler's disease. A historical perspective and report of a case. 61
3904234 1985
16
Silo filler's disease. 61
6433237 1984
17
Feed-associated respiratory illness in farmers. 61
6712283 1984
18
Silo-Filler's disease in rural New York. 61
6813669 1982
19
Silo-filler's disease. 61
688149 1978
20
Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the leterature. 61
627925 1978
21
Lung disease in farmers. 61
321110 1977
22
Silo-Filler's disease. 61
1118673 1975
23
Silo filler's disease. 61
4703623 1973
24
Silo Filler's disease. 61
5048897 1972
25
[Poisoning caused by nitrous fumes during ensilage. Silo-filler's disease]. 61
5022614 1972
26
[Silo filler's disease]. 61
5111139 1971
27
Silo-filler's disease: nitrogen dioxide-induced lung injury. Long-term follow-up and review of the literature. 61
5573158 1971
28
[Silo filler's disease]. 61
5973378 1966
29
FARMER'S LUNG AND SILO-FILLER'S DISEASE. 61
14148161 1964
30
OCCURRENCE OF SILO FILLERS' DISEASE IN CHILDREN. 61
14149005 1964
31
"SILO FILLER'S DISEASE" IN DAIRY CATTLE. 61
14077958 1963
32
Silo fillers disease. 61
13990229 1963
33
[Silo-filler's disease. Clinical contribution]. 61
13948081 1963
34
Silo Filler's disease. Relapse following latent period. 61
14489845 1961
35
Silo-filler's disease. 61
13812011 1960
36
Silo-filler's disease: report of two cases in Henderson County, North Carolina. 61
13820978 1960
37
Chronic silo filler's disease. 61
13597567 1958
38
Chronic pulmonary insufficiency secondary to silo-filler's disease. 61
13520747 1958
39
Silo-fillers disease; report of a case. 61
13517515 1958
40
Silo-filler's disease; a syndrome caused by nitrogen dioxide. 61
13357306 1956
41
Silo-Filler's Disease. 61
20325316 1956
42
Silo-filler's disease. 61
13310596 1956

Variations for Silo Filler's Disease

Expression for Silo Filler's Disease

Search GEO for disease gene expression data for Silo Filler's Disease.

Pathways for Silo Filler's Disease

Pathways related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 TLR4 TLR2 MYD88 MUC5AC ITGAX ITGAM
2
Show member pathways
13.81 ITGAX ITGAM IL5 IL1R1 IL1B IL17A
3
Show member pathways
13.53 ITGAX ITGAM IL5 IL1R1 IL1B IL17A
4
Show member pathways
13.36 MYD88 ITGAX ITGAM IL5 IL1R1 IL1B
5
Show member pathways
13.29 IL5 IL1R1 IL1B IL17A CCL20 AREG
6
Show member pathways
13.21 TLR4 TLR2 MYD88 IL1R1 IL1B IFNGR2
7
Show member pathways
13.05 TLR4 TLR2 SFTPD MYD88 IL1B IFNGR2
8
Show member pathways
12.9 TLR4 TLR2 MYD88 IL1R1 IL1B
9
Show member pathways
12.88 TLR4 TLR2 MYD88 ITGAX ITGAM IL5
10
Show member pathways
12.84 TLR4 TLR2 MYD88 IL1B IFNGR2 ACTG1
11
Show member pathways
12.76 TLR4 TLR2 MYD88 IL1R1 IL1B ACTG1
12
Show member pathways
12.74 TLR4 TLR2 MYD88 MUC5AC IL1R1 IL1B
13
Show member pathways
12.72 TLR4 TLR2 MYD88 IL1R1 IL1B AREG
14
Show member pathways
12.6 TLR4 TLR2 MYD88 IL1R1 IL1B
15 12.52 TLR2 MYD88 IL1B IL17A
16
Show member pathways
12.52 TLR4 TLR2 MYD88 IL5 IL1B IL17A
17
Show member pathways
12.49 TLR4 TLR2 IL5 IL1R1 IL1B IL17A
18 12.43 TLR4 MYD88 IL1R1 IL1B ACTG1
19
Show member pathways
12.38 TLR4 TLR2 MYD88 ACTG1
20
Show member pathways
12.37 TLR2 MUC5AC IL5 IL1B IL17A CCL20
21
Show member pathways
12.35 TLR4 MYD88 IL1R1 IL1B IFNGR2
22
Show member pathways
12.25 TLR4 TLR2 MYD88 ITGAM IL1B IFNGR2
23
Show member pathways
12.22 IL5 IL1B IL17A AREG
24 12.1 TLR4 MYD88 IL1B ACTG1
25
Show member pathways
12.08 TLR4 TLR2 IL5 IL1R1 IL1B
26 12.03 TLR4 TLR2 SFTPD MSR1 ITGAM ACTG1
27 12.02 ITGAX ITGAM IL1B IL17A
28 11.98 TLR4 MYD88 IL1R1 IL1B
29 11.98 TLR4 TLR2 ITGAM IL1R1 IL1B
30 11.97 TLR4 IL1R1 IL1B
31 11.96 TLR4 TLR2 MYD88 ITGAX ITGAM IL1B
32 11.95 ITGAX ITGAM IL5
33 11.94 ITGAM IL5 IL1R1 IL1B
34 11.91 TLR4 TLR2 IL1B IL17A CCL20
35
Show member pathways
11.89 TLR4 TLR2 IL1R1 IL1B IL17A
36 11.85 TLR4 TLR2 MSR1 ITGAX ITGAM
37
Show member pathways
11.84 TLR4 MYD88 IL17A
38 11.8 TLR4 MYD88 ITGAM IL1B
39 11.78 ITGAM IL5 IL1R1 IL1B IL17A
40 11.74 ITGAX ITGAM IL1B
41
Show member pathways
11.74 TLR4 TLR2 IL1B IL17A IFNGR2
42 11.69 TLR4 TLR2 IL5
43 11.62 ITGAX ITGAM ACTG1
44 11.61 TLR4 TLR2 MYD88 IL1B
45 11.59 TLR4 MYD88 IL1R1
46 11.55 IL1R1 IL1B CCL20
47 11.48 TLR4 TLR2 MYD88 ITGAM IL1B
48
Show member pathways
11.44 TLR4 TLR2 SFTPD MYD88 IL1R1 IL1B
49 11.37 IL5 IL1B IL17A AREG
50 11.34 TLR4 TLR2 ITGAM IL1B ACTG1

GO Terms for Silo Filler's Disease

Cellular components related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.63 TLR4 TLR2 ITGAX ITGAM IL1R1 AREG
2 external side of plasma membrane GO:0009897 9.43 TLR4 MSR1 ITGAX ITGAM IL1R1 IL17A
3 extracellular space GO:0005615 9.32 SFTPD POTEF MUC5AC ITGAM IL5 IL1B

Biological processes related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.25 TLR4 TLR2 MYD88 IL5 IL1R1 IL1B
2 immune system process GO:0002376 10.1 TLR4 TLR2 SFTPD MYD88 ITGAM IL17A
3 innate immune response GO:0045087 10.02 TLR4 TLR2 SFTPD MYD88 ITGAM IL17A
4 defense response to bacterium GO:0042742 9.96 TLR4 SFTPD MYD88 CCL20
5 positive regulation of gene expression GO:0010628 9.95 TLR4 TLR2 MYD88 ITGAX IL1B ACTG1
6 cell-cell signaling GO:0007267 9.94 IL1B IL17A CCL20 AREG
7 response to lipopolysaccharide GO:0032496 9.9 TLR4 TLR2 MYD88 IL1B
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TLR4 TLR2 MYD88 IL1B
9 immune response GO:0006955 9.87 TLR4 TLR2 IL5 IL1R1 IL1B IL17A
10 defense response to Gram-positive bacterium GO:0050830 9.86 TLR2 MYD88 IL17A
11 interleukin-1-mediated signaling pathway GO:0070498 9.85 MYD88 IL1R1 IL1B
12 positive regulation of inflammatory response GO:0050729 9.85 TLR4 TLR2 IL1B
13 regulation of inflammatory response GO:0050727 9.85 TLR4 MYD88 IL1R1
14 positive regulation of JNK cascade GO:0046330 9.84 TLR4 MYD88 IL1B
15 cellular response to mechanical stimulus GO:0071260 9.83 TLR4 MYD88 IL1B
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TLR4 TLR2 IL1B
17 positive regulation of interferon-gamma production GO:0032729 9.8 TLR4 IL1R1 IL1B
18 positive regulation of interleukin-12 production GO:0032735 9.76 TLR4 TLR2 IL17A
19 cellular response to interferon-gamma GO:0071346 9.76 TLR4 TLR2 CCL20 ACTG1
20 response to interleukin-1 GO:0070555 9.75 MYD88 IL1R1 IL1B
21 positive regulation of chemokine production GO:0032722 9.74 TLR4 TLR2 MYD88
22 positive regulation of tumor necrosis factor production GO:0032760 9.73 TLR4 TLR2 MYD88 IL17A
23 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.71 TLR4 TLR2 MYD88
24 positive regulation of interleukin-8 production GO:0032757 9.71 TLR4 TLR2 MYD88 IL1B
25 microglial cell activation GO:0001774 9.7 TLR2 ITGAM IFNGR2
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR4 TLR2
27 positive regulation of keratinocyte proliferation GO:0010838 9.69 TLR4 AREG
28 amyloid-beta clearance GO:0097242 9.68 MSR1 ITGAM
29 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.67 TLR4 MYD88
30 I-kappaB phosphorylation GO:0007252 9.67 TLR4 TLR2
31 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.67 TLR4 MYD88 IL17A
32 toll-like receptor signaling pathway GO:0002224 9.67 TLR4 TLR2 SFTPD MYD88
33 cellular response to lipoteichoic acid GO:0071223 9.65 TLR4 TLR2
34 positive regulation of lymphocyte proliferation GO:0050671 9.64 TLR4 MYD88
35 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.62 IL1R1 IL1B
36 intestinal epithelial structure maintenance GO:0060729 9.61 TLR4 IL17A
37 positive regulation of interleukin-23 production GO:0032747 9.61 MYD88 IL17A
38 positive regulation of matrix metallopeptidase secretion GO:1904466 9.56 TLR4 TLR2
39 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 TLR4 TLR2 MYD88 IL1B
40 inflammatory response GO:0006954 9.56 TLR4 TLR2 MYD88 IL5 IL1R1 IL1B
41 positive regulation of interleukin-6 production GO:0032755 9.55 TLR4 TLR2 MYD88 IL1B IL17A
42 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.51 TLR4 TLR2
43 cytokine-mediated signaling pathway GO:0019221 9.28 MYD88 ITGAX ITGAM IL5 IL1R1 IL1B

Molecular functions related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.33 TLR4 TLR2 SFTPD POTEF MYD88 MUC5AC
2 cytokine activity GO:0005125 9.65 IL5 IL1B IL17A CCL20 AREG
3 cargo receptor activity GO:0038024 9.46 MSR1 ITGAM
4 amyloid-beta binding GO:0001540 9.46 TLR4 TLR2 MSR1 ITGAM
5 interleukin-1 receptor binding GO:0005149 9.43 MYD88 IL1B
6 Toll-like receptor binding GO:0035325 9.37 TLR2 MYD88
7 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
8 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.13 TLR4 TLR2 IL1R1
9 NAD(P)+ nucleosidase activity GO:0050135 8.8 TLR4 TLR2 IL1R1

Sources for Silo Filler's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....