MCID: SLF002
MIFTS: 35

Silo Filler's Disease

Categories: Respiratory diseases

Aliases & Classifications for Silo Filler's Disease

MalaCards integrated aliases for Silo Filler's Disease:

Name: Silo Filler's Disease 12 43 15 17 71
Silo-Fillers' Disease 12
Silo Filler Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4374
MeSH 43 D012832
SNOMED-CT 67 61233003
UMLS 71 C0037120

Summaries for Silo Filler's Disease

MalaCards based summary : Silo Filler's Disease, also known as silo-fillers' disease, is related to bronchiolitis obliterans and respiratory failure, and has symptoms including edema An important gene associated with Silo Filler's Disease is LMBR1 (Limb Development Membrane Protein 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, eye and bone, and related phenotypes are growth/size/body region and digestive/alimentary

Related Diseases for Silo Filler's Disease

Diseases related to Silo Filler's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 30.4 TLR4 SFTPD IL17A
2 respiratory failure 30.3 SFTPD MUC5AC IL5 IL1R1
3 bronchiolitis 29.7 TLR4 TLR2 SFTPD MUC5AC IL5 IL17A
4 farmer's lung 11.9
5 pulmonary edema 10.5
6 prosthetic joint infection 10.5 TLR4 TLR2
7 fungal keratitis 10.4 TLR4 TLR2
8 gastrointestinal tularemia 10.4 TLR4 TLR2 MYD88
9 superficial basal cell carcinoma 10.4 TLR4 TLR2 MYD88
10 myd88 deficiency 10.4 TLR4 TLR2 MYD88
11 irak4 deficiency 10.4 TLR4 TLR2 MYD88
12 anogenital venereal wart 10.4 TLR4 TLR2 MYD88
13 nonspecific interstitial pneumonia 10.3
14 swyer-james syndrome 10.3
15 filarial elephantiasis 10.3 TLR4 TLR2 IL5
16 q fever 10.3 TLR4 TLR2 MYD88
17 bacterial sepsis 10.3 TLR4 TLR2 MYD88
18 hydrops, lactic acidosis, and sideroblastic anemia 10.3
19 aphthous stomatitis 10.3 TLR4 TLR2 IL5
20 atopic keratoconjunctivitis 10.3 MUC5AC IL5
21 invasive aspergillosis 10.3 TLR4 TLR2 SFTPD
22 neisseria meningitidis infection 10.3 TLR4 TLR2 IL1R1
23 filariasis 10.3 TLR4 TLR2 IL5
24 middle ear disease 10.2 TLR4 TLR2 MUC5AC
25 paracoccidioidomycosis 10.2 TLR4 TLR2 MYD88 IL5
26 status asthmaticus 10.2 MUC5AC IL5 IL1R1
27 spondylarthropathy 10.1 TLR4 TLR2
28 neurosyphilis 10.1 TLR2 IL17A
29 lymphoma, mucosa-associated lymphoid type 10.1 TLR4 TLR2 MYD88
30 toxic shock syndrome 10.1 TLR4 TLR2 IL1R1
31 indolent myeloma 10.1 IL1R1 CASP1
32 norwegian scabies 10.1 IL5 IL17A
33 bronchitis 10.1 TLR4 TLR2 IL5
34 pneumonic plague 10.1 TLR4 TLR2 IL17A
35 candidiasis 10.0 TLR4 TLR2 IL17A
36 trypanosomiasis 10.0 TLR4 TLR2 MYD88
37 primary systemic mycosis 10.0 TLR4 TLR2 IL17A
38 metal allergy 10.0 TLR4 IL17A
39 gout 10.0 TLR4 TLR2 IL1R1
40 cystic echinococcosis 10.0 TLR4 TLR2 IL17A
41 amebiasis 10.0 TLR4 TLR2 IL17A
42 gingival disease 10.0 TLR4 TLR2 IL17A
43 splenic disease 10.0 TLR4 TLR2 IL17A
44 vaginal disease 10.0 TLR4 TLR2 IL17A
45 scrub typhus 10.0 TLR4 TLR2 IL17A
46 rectal disease 10.0 TLR4 TLR2 IL17A
47 mycoplasma pneumoniae pneumonia 10.0 TLR2 SFTPD IL17A
48 osteomyelitis 10.0 TLR4 TLR2 CASP1
49 aggressive periodontitis 10.0 TLR4 TLR2 IL17A
50 periodontitis 10.0 TLR4 TLR2 IL17A

Graphical network of the top 20 diseases related to Silo Filler's Disease:



Diseases related to Silo Filler's Disease

Symptoms & Phenotypes for Silo Filler's Disease

UMLS symptoms related to Silo Filler's Disease:


edema

MGI Mouse Phenotypes related to Silo Filler's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 ACTG1 AREG CDON IL17A IL1R1 IL5
2 digestive/alimentary MP:0005381 10.07 ACTG1 AREG CASP1 CDON IL17A IL5
3 hematopoietic system MP:0005397 10.03 AREG CASP1 IL17A IL1R1 IL5 ITGAM
4 immune system MP:0005387 9.97 AREG CASP1 IL17A IL1R1 IL5 ITGAM
5 mortality/aging MP:0010768 9.77 ACTG1 AREG CASP1 CDON IL17A IL1R1
6 respiratory system MP:0005388 9.23 CDON IL17A IL1R1 IL5 MYD88 SFTPD

Drugs & Therapeutics for Silo Filler's Disease

Search Clinical Trials , NIH Clinical Center for Silo Filler's Disease

Cochrane evidence based reviews: silo filler's disease

Genetic Tests for Silo Filler's Disease

Anatomical Context for Silo Filler's Disease

MalaCards organs/tissues related to Silo Filler's Disease:

40
Lung, Eye, Bone, Lymph Node, Skin, Tonsil

Publications for Silo Filler's Disease

Articles related to Silo Filler's Disease:

(show all 41)
# Title Authors PMID Year
1
Silo-Filler's Disease: One Health System's Experience and an Update of the Literature. 61
30879430 2020
2
Nitrogen dioxide (silo gas) poisoning in dairy cattle. 61
17990632 2007
3
Silo-Filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. 61
15353441 2004
4
[Respiratory pathology in the agricultural environment]. 61
9781190 1998
5
Lung (agricultural/rural). 61
8637735 1996
6
Case of the season. Silo filler's disease in a patient with prior Swyer-James syndrome. 61
8272877 1993
7
Silo filler's disease in New York State. 61
1519842 1992
8
Hazardous exposure and lung disease among farm workers. 61
1511556 1992
9
[Acute dyspnea, cough, headache]. 61
2020781 1991
10
The Bassett Farm Safety and Health Project. 61
2248240 1990
11
[A case of silo-fillers' disease]. 61
2615101 1989
12
Silo-filler's disease. 61
2704252 1989
13
Silo-filler's disease: a new perspective. 61
2704256 1989
14
Silo-filler's disease. A historical perspective and report of a case. 61
3904234 1985
15
Silo filler's disease. 61
6433237 1984
16
Feed-associated respiratory illness in farmers. 61
6712283 1984
17
Silo-Filler's disease in rural New York. 61
6813669 1982
18
Silo-filler's disease. 61
688149 1978
19
Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the leterature. 61
627925 1978
20
Lung disease in farmers. 61
321110 1977
21
Silo-Filler's disease. 61
1118673 1975
22
Silo filler's disease. 61
4703623 1973
23
Silo Filler's disease. 61
5048897 1972
24
[Poisoning caused by nitrous fumes during ensilage. Silo-filler's disease]. 61
5022614 1972
25
[Silo filler's disease]. 61
5111139 1971
26
Silo-filler's disease: nitrogen dioxide-induced lung injury. Long-term follow-up and review of the literature. 61
5573158 1971
27
[Silo filler's disease]. 61
5973378 1966
28
FARMER'S LUNG AND SILO-FILLER'S DISEASE. 61
14148161 1964
29
OCCURRENCE OF SILO FILLERS' DISEASE IN CHILDREN. 61
14149005 1964
30
"SILO FILLER'S DISEASE" IN DAIRY CATTLE. 61
14077958 1963
31
Silo fillers disease. 61
13990229 1963
32
[Silo-filler's disease. Clinical contribution]. 61
13948081 1963
33
Silo Filler's disease. Relapse following latent period. 61
14489845 1961
34
Silo-filler's disease. 61
13812011 1960
35
Silo-filler's disease: report of two cases in Henderson County, North Carolina. 61
13820978 1960
36
Chronic silo filler's disease. 61
13597567 1958
37
Chronic pulmonary insufficiency secondary to silo-filler's disease. 61
13520747 1958
38
Silo-fillers disease; report of a case. 61
13517515 1958
39
Silo-filler's disease; a syndrome caused by nitrogen dioxide. 61
13357306 1956
40
Silo-Filler's Disease. 61
20325316 1956
41
Silo-filler's disease. 61
13310596 1956

Variations for Silo Filler's Disease

Expression for Silo Filler's Disease

Search GEO for disease gene expression data for Silo Filler's Disease.

Pathways for Silo Filler's Disease

Pathways related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TLR4 TLR2 MYD88 MUC5AC ITGAX ITGAM
2
Show member pathways
13.81 ITGAX ITGAM IL5 IL1R1 IL17A CXCL1
3
Show member pathways
13.28 IL5 IL1R1 IL17A CXCL1 CCL20 CASP1
4
Show member pathways
13.27 MYD88 ITGAX ITGAM IL5 IL1R1 IL17A
5
Show member pathways
12.88 TLR4 TLR2 MYD88 ITGAX ITGAM IL5
6
Show member pathways
12.79 TLR4 TLR2 MYD88 CASP1 ACTG1
7
Show member pathways
12.7 TLR4 TLR2 MYD88 IL1R1 AREG
8
Show member pathways
12.59 TLR4 TLR2 MYD88 IL5 IL17A
9
Show member pathways
12.59 TLR4 TLR2 IL5 IL1R1 IL17A
10
Show member pathways
12.57 TLR4 TLR2 MYD88 IL1R1 CASP1
11 12.36 TLR4 MYD88 IL1R1 CASP1 ACTG1
12
Show member pathways
12.26 TLR4 TLR2 MYD88 ITGAM
13 12.26 TLR4 MYD88 IL1R1 CASP1 ACTG1
14
Show member pathways
12.24 TLR2 MUC5AC IL5 IL17A CXCL1 CCL20
15 12.23 TLR4 MYD88 CXCL1 CASP1
16
Show member pathways
12.21 TLR2 MYD88 MUC5AC IL1R1
17 12.18 TLR4 TLR2 MYD88 ITGAX ITGAM
18
Show member pathways
12.05 TLR4 TLR2 IL1R1 IL17A
19
Show member pathways
12.03 TLR4 TLR2 MSR1 ITGAM
20
Show member pathways
12.02 TLR4 TLR2 IL5 IL1R1
21 12 TLR4 MYD88 CASP1 ACTG1
22 11.95 ITGAX ITGAM CASP1 ACTG1
23
Show member pathways
11.95 TLR4 TLR2 SFTPD MYD88 IL1R1 CCL20
24 11.91 TLR4 MYD88 IL1R1 CXCL1
25 11.86 ITGAM IL5 IL1R1
26 11.86 TLR4 TLR2 ITGAM IL1R1 CXCL1
27
Show member pathways
11.85 TLR4 MYD88 IL17A CXCL1
28 11.81 TLR4 TLR2 SFTPD MSR1 ITGAM ACTG1
29 11.77 ITGAM IL5 IL1R1 IL17A
30 11.77 TLR4 TLR2 IL17A CXCL1 CCL20
31 11.73 TLR4 MYD88 ITGAM CASP1
32 11.7 TLR4 TLR2 MSR1 ITGAX ITGAM
33 11.69 MSR1 IL17A CXCL1 CCL20
34 11.62 TLR4 MYD88 CXCL1 CASP1 ACTG1
35 11.61 ITGAX ITGAM ACTG1
36 11.58 TLR4 MYD88 IL1R1
37 11.54 TLR4 TLR2 MYD88
38 11.52 IL1R1 CXCL1 CCL20
39 11.46 TLR4 TLR2 ITGAM ACTG1
40 11.3 IL5 IL17A AREG
41 11.17 TLR2 MYD88 IL1R1
42 10.94 ITGAX ITGAM IL5 IL17A CXCL1 CCL20
43 10.86 TLR4 TLR2 MYD88 ITGAM CXCL1 CASP1

GO Terms for Silo Filler's Disease

Cellular components related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 TLR4 ITGAX ITGAM IL1R1 IL17A
2 cell surface GO:0009986 9.43 TLR4 TLR2 ITGAX ITGAM IL1R1 AREG
3 extracellular space GO:0005615 9.32 SFTPD POTEF MUC5AC ITGAM IL5 IL17A
4 low-density lipoprotein particle GO:0034362 9.26 MSR1 LSR

Biological processes related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.19 TLR4 TLR2 MYD88 IL5 IL1R1 CXCL1
2 innate immune response GO:0045087 10.01 TLR4 TLR2 SFTPD MYD88 ITGAM
3 defense response to bacterium GO:0042742 9.91 TLR4 SFTPD MYD88 CCL20
4 immune response GO:0006955 9.87 TLR4 TLR2 IL5 IL1R1 IL17A CXCL1
5 cellular response to lipopolysaccharide GO:0071222 9.85 TLR4 MYD88 CXCL1 CASP1
6 cellular response to mechanical stimulus GO:0071260 9.76 TLR4 MYD88 CASP1
7 apoptotic signaling pathway GO:0097190 9.74 TLR4 ITGAM CASP1
8 positive regulation of interleukin-6 production GO:0032755 9.73 TLR4 TLR2 MYD88
9 positive regulation of interleukin-6 secretion GO:2000778 9.69 TLR4 TLR2 IL17A
10 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR4 TLR2 MYD88
11 regulation of inflammatory response GO:0050727 9.67 TLR4 MYD88 IL1R1 CASP1
12 positive regulation of interleukin-8 production GO:0032757 9.65 TLR4 TLR2 MYD88
13 positive regulation of interleukin-8 secretion GO:2000484 9.63 TLR4 TLR2
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR4 TLR2
15 amyloid-beta clearance GO:0097242 9.62 MSR1 ITGAM
16 positive regulation of keratinocyte proliferation GO:0010838 9.62 TLR4 AREG
17 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.6 TLR4 MYD88
18 I-kappaB phosphorylation GO:0007252 9.59 TLR4 TLR2
19 cellular response to lipoteichoic acid GO:0071223 9.58 TLR4 TLR2
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TLR4 MYD88 IL17A
21 toll-like receptor signaling pathway GO:0002224 9.56 TLR4 TLR2 SFTPD MYD88
22 inflammatory response GO:0006954 9.56 TLR4 TLR2 MYD88 IL5 IL1R1 IL17A
23 cellular response to interferon-gamma GO:0071346 9.55 TLR4 TLR2 CCL20 CASP1 ACTG1
24 positive regulation of interleukin-23 production GO:0032747 9.52 MYD88 IL17A
25 positive regulation of matrix metallopeptidase secretion GO:1904466 9.46 TLR4 TLR2
26 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.43 TLR4 TLR2
27 cytokine-mediated signaling pathway GO:0019221 9.23 ITGAX ITGAM IL5 IL1R1 IL17A CXCL1

Molecular functions related to Silo Filler's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.33 TLR4 TLR2 SFTPD POTEF MYD88 MUC5AC
2 cargo receptor activity GO:0038024 9.37 MSR1 ITGAM
3 cytokine activity GO:0005125 9.35 IL5 IL17A CXCL1 CCL20 AREG
4 lipopolysaccharide binding GO:0001530 9.33 TLR4 TLR2 SFTPD
5 Toll-like receptor binding GO:0035325 9.32 TLR2 MYD88
6 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
7 amyloid-beta binding GO:0001540 8.92 TLR4 TLR2 MSR1 ITGAM

Sources for Silo Filler's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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