Silo Filler's Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SLF002 MIFTS: 35	Silo Filler's Disease Categories: Respiratory diseases
Genes Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Silo Filler's Disease

MalaCards integrated aliases for Silo Filler's Disease:

Name: Silo Filler's Disease ¹² ⁴⁴ ¹⁵ ¹⁷ ⁷¹

Silo-Fillers' Disease ¹²

Silo Filler Disease ¹²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4374

MeSH ⁴⁴ D012832

SNOMED-CT ⁶⁷ 61233003

EFO ¹⁷ EFO_1001182

UMLS ⁷¹ C0037120

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Summaries for Silo Filler's Disease

Disease Ontology : ¹² A lung disease that is characterized by inhalation of nitrogen oxides from exposure to silage gas in recently filled silos resulting in sudden death, pulmonary edema, and/or bronchiolitis obliterans.

MalaCards based summary : Silo Filler's Disease, also known as silo-fillers' disease, is related to bronchiolitis obliterans and adult respiratory distress syndrome, and has symptoms including edema An important gene associated with Silo Filler's Disease is MYD88 (MYD88 Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Silo Filler's Disease

Diseases related to Silo Filler's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)

#	Related Disease	Score	Top Affiliating Genes
1	bronchiolitis obliterans	30.4	TLR4 SFTPD IL17A
2	adult respiratory distress syndrome	29.5	SFTPD ITGAM IL1R1 IL1B
3	bronchiolitis	29.4	TLR4 TLR2 SFTPD IL5 IL1B IL17A
4	farmer's lung	11.3
5	pulmonary edema	10.4
6	endometrial mixed adenocarcinoma	10.3	TLR2 MYD88
7	fungal keratitis	10.3	TLR4 TLR2
8	mycobacterium abscessus	10.3	TLR2 IFNGR2
9	glanders	10.3	TLR4 MYD88
10	chronic purulent otitis media	10.3	TLR4 TLR2
11	superficial basal cell carcinoma	10.3	TLR4 TLR2 MYD88
12	gastrointestinal tularemia	10.3	TLR4 TLR2 MYD88
13	filarial elephantiasis	10.3	TLR4 TLR2 IL5
14	atopic keratoconjunctivitis	10.3	MUC5AC IL5
15	filariasis	10.2	TLR4 TLR2 IL5
16	human monocytic ehrlichiosis	10.2	TLR2 MYD88
17	invasive aspergillosis	10.2	TLR4 TLR2 SFTPD
18	nonspecific interstitial pneumonia	10.2
19	swyer-james syndrome	10.2
20	chromium allergic contact dermatitis	10.2	IL5 IL17A
21	neurosyphilis	10.2	TLR2 IL17A
22	lymphoma, mucosa-associated lymphoid type	10.2	TLR4 TLR2 MYD88
23	norwegian scabies	10.2	IL5 IL17A
24	metal allergy	10.2	TLR4 IL17A
25	paracoccidioidomycosis	10.2	TLR4 TLR2 MYD88 IL5
26	granulomatosis with polyangiitis	10.2	TLR4 TLR2 IL5
27	hereditary angioedema with normal c1inh	10.1	TLR4 TLR2
28	pneumonic plague	10.1	TLR4 TLR2 IL17A
29	cystic echinococcosis	10.1	TLR4 TLR2 IL17A
30	ileitis	10.1	TLR4 TLR2 IL17A
31	mycoplasma pneumoniae pneumonia	10.1	TLR2 SFTPD IL17A
32	trichinosis	10.1	IL5 IL17A
33	neisseria meningitidis infection	10.1	TLR4 TLR2 IL1R1
34	hyper ige syndrome	10.0	TLR4 TLR2 IL17A
35	localized pulmonary fibrosis	10.0	SFTPD IL1B
36	anaerobic pneumonia	10.0	TLR2 IL1B
37	keratoconjunctivitis	10.0	MUC5AC IL5 IL17A
38	echinococcosis	10.0	TLR4 TLR2 IL5 IL17A
39	food allergy	10.0	TLR4 TLR2 IL5 IL17A
40	status asthmaticus	10.0	MUC5AC IL5 IL1R1
41	prosthetic joint infection	10.0	TLR4 TLR2 IL1B
42	congenital cytomegalovirus	10.0	TLR4 TLR2 IL1B
43	pemphigoid	10.0	IL5 IL1B
44	dental pulp disease	9.9	TLR4 TLR2 IL1B
45	suppurative otitis media	9.9	TLR4 TLR2 IL1B
46	chlamydia pneumonia	9.9	TLR4 TLR2 IL1B
47	urethritis	9.9	TLR4 TLR2 IL1B
48	pyelitis	9.9	TLR4 TLR2 IL1B
49	fallopian tube disease	9.9	TLR4 TLR2 IL1B
50	endometrial disease	9.9	TLR4 TLR2 IL1B

Graphical network of the top 20 diseases related to Silo Filler's Disease:

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Symptoms & Phenotypes for Silo Filler's Disease

UMLS symptoms related to Silo Filler's Disease:

edema

MGI Mouse Phenotypes related to Silo Filler's Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.13	AREG IFNGR2 IL17A IL1B IL1R1 IL5
2	homeostasis/metabolism	MP:0005376	10.1	AREG CCL20 IFNGR2 IL17A IL1B IL1R1
3	digestive/alimentary	MP:0005381	10.02	ACTG1 AREG IL17A IL1R1 IL5 MUC5AC
4	immune system	MP:0005387	10	AREG IFNGR2 IL17A IL1B IL1R1 IL5
5	neoplasm	MP:0002006	9.43	IL1B IL1R1 IL5 MYD88 TLR2 TLR4
6	respiratory system	MP:0005388	9.17	IL17A IL1R1 IL5 MYD88 SFTPD TLR2

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Drugs & Therapeutics for Silo Filler's Disease

Search Clinical Trials , NIH Clinical Center for Silo Filler's Disease

Cochrane evidence based reviews: silo filler's disease

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Genetic Tests for Silo Filler's Disease

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Anatomical Context for Silo Filler's Disease

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Publications for Silo Filler's Disease

Articles related to Silo Filler's Disease:

(show all 42)

#	Title	Authors	PMID	Year
1	Ultraviolet Photoactivated Room Temperature NO2 Gas Sensor of ZnO Hemitubes and Nanotubes Covered with TiO2 Nanoparticles. ⁶¹	Choi HJ...Kim KK	32143528	2020
2	Silo-Filler's Disease: One Health System's Experience and an Update of the Literature. ⁶¹	Amaza IP...Kreidy MP	30879430	2020
3	Nitrogen dioxide (silo gas) poisoning in dairy cattle. ⁶¹	Verhoeff J...Hamhuis D	17990632	2007
4	Silo-Filler's disease, the acute respiratory distress syndrome, and oxides of nitrogen. ⁶¹	Leavey JF...Kaminsky DA	15353441	2004
5	[Respiratory pathology in the agricultural environment]. ⁶¹	Dalphin JC	9781190	1998
6	Lung (agricultural/rural). ⁶¹	do Pico GA	8637735	1996
7	Case of the season. Silo filler's disease in a patient with prior Swyer-James syndrome. ⁶¹	Hirsch J...Fencel RM	8272877	1993
8	Silo filler's disease in New York State. ⁶¹	Zwemer FL...May JJ	1519842	1992
9	Hazardous exposure and lung disease among farm workers. ⁶¹	do Pico GA	1511556	1992
10	[Acute dyspnea, cough, headache]. ⁶¹	Misteli M...Ragaz A	2020781	1991
11	The Bassett Farm Safety and Health Project. ⁶¹	Pratt DS	2248240	1990
12	[A case of silo-fillers' disease]. ⁶¹	Shiramine K...Ishimaru O	2615101	1989
13	Silo-filler's disease. ⁶¹	Douglas WW...Colby TV	2704252	1989
14	Silo-filler's disease: a new perspective. ⁶¹	Epler GR	2704256	1989
15	Silo-filler's disease. A historical perspective and report of a case. ⁶¹	Maurer WJ	3904234	1985
16	Silo filler's disease. ⁶¹	Jonas DO	6433237	1984
17	Feed-associated respiratory illness in farmers. ⁶¹	Pratt DS...May JJ	6712283	1984
18	Silo-Filler's disease in rural New York. ⁶¹	Centers for Disease Control (CDC)	6813669	1982
19	Silo-filler's disease. ⁶¹	Fleetham JA...Tunnicliffe BW	688149	1978
20	Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the leterature. ⁶¹	Horvath EP...Dickie HA	627925	1978
21	Lung disease in farmers. ⁶¹	Warren CP	321110	1977
22	Silo-Filler's disease. ⁶¹	Morrissey WL...Gaensler EA	1118673	1975
23	Silo filler's disease. ⁶¹	Scott EG...Hunt WB	4703623	1973
24	Silo Filler's disease. ⁶¹	McCabe WO	5048897	1972
25	[Poisoning caused by nitrous fumes during ensilage. Silo-filler's disease]. ⁶¹	Fallentin B...Frost J	5022614	1972
26	[Silo filler's disease]. ⁶¹	Woie L	5111139	1971
27	Silo-filler's disease: nitrogen dioxide-induced lung injury. Long-term follow-up and review of the literature. ⁶¹	Ramirez J...Dowell AR	5573158	1971
28	[Silo filler's disease]. ⁶¹	Eichenberger G...Hausser E	5973378	1966
29	FARMER'S LUNG AND SILO-FILLER'S DISEASE. ⁶¹	DONOGHUE FE...SCHMIDT HW	14148161	1964
30	OCCURRENCE OF SILO FILLERS' DISEASE IN CHILDREN. ⁶¹	OLSON ET	14149005	1964
31	"SILO FILLER'S DISEASE" IN DAIRY CATTLE. ⁶¹	HAYNES NB	14077958	1963
32	Silo fillers disease. ⁶¹	SPOLYAR LW	13990229	1963
33	[Silo-filler's disease. Clinical contribution]. ⁶¹	GIORDANO A...PRATESI AC	13948081	1963
34	Silo Filler's disease. Relapse following latent period. ⁶¹	RAFII S...GODWIN MC	14489845	1961
35	Silo-filler's disease. ⁶¹	CORNELIUS EA...BETLACH EH	13812011	1960
36	Silo-filler's disease: report of two cases in Henderson County, North Carolina. ⁶¹	EVANS EG...PORTER RA	13820978	1960
37	Chronic silo filler's disease. ⁶¹	SCHELL HW	13597567	1958
38	Chronic pulmonary insufficiency secondary to silo-filler's disease. ⁶¹	LEIB GM...McQUIGGAN M	13520747	1958
39	Silo-fillers disease; report of a case. ⁶¹	GAILITIS J...NALLY JB	13517515	1958
40	Silo-filler's disease; a syndrome caused by nitrogen dioxide. ⁶¹	LOWRY T...SCHUMAN LM	13357306	1956
41	Silo-Filler's Disease. ⁶¹		20325316	1956
42	Silo-filler's disease. ⁶¹	DELANEY LT...STROEBEL CF	13310596	1956

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Genes for Silo Filler's Disease

Genes related to Silo Filler's Disease (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	4.68	DISEASES inferred ¹⁵
2	TLR2	Toll Like Receptor 2	Protein Coding	4.52	DISEASES inferred ¹⁵
3	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	4.48	DISEASES inferred ¹⁵
4	IL5	Interleukin 5	Protein Coding	4.45	DISEASES inferred ¹⁵
5	TLR4	Toll Like Receptor 4	Protein Coding	4.22	DISEASES inferred ¹⁵
6	MSR1	Macrophage Scavenger Receptor 1	Protein Coding	4.15	DISEASES inferred ¹⁵
7	SFTPD	Surfactant Protein D	Protein Coding	4.05	DISEASES inferred ¹⁵
8	ITGAX	Integrin Subunit Alpha X	Protein Coding	3.85	DISEASES inferred ¹⁵
9	AREG	Amphiregulin	Protein Coding	3.65	DISEASES inferred ¹⁵
10	POTEF	POTE Ankyrin Domain Family Member F	Protein Coding	3.59	DISEASES inferred ¹⁵
11	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	3.59	DISEASES inferred ¹⁵
12	ITGAM	Integrin Subunit Alpha M	Protein Coding	3.58	DISEASES inferred ¹⁵
13	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	3.48	DISEASES inferred ¹⁵
14	ACTG1	Actin Gamma 1	Protein Coding	3.47	DISEASES inferred ¹⁵
15	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	3.47	DISEASES inferred ¹⁵
16	IL1B	Interleukin 1 Beta	Protein Coding	3.35	DISEASES inferred ¹⁵
17	IL17A	Interleukin 17A	Protein Coding	3.26	DISEASES inferred ¹⁵

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Variations for Silo Filler's Disease

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Expression for Silo Filler's Disease

Search GEO for disease gene expression data for Silo Filler's Disease.

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Pathways for Silo Filler's Disease

Pathways related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14	TLR4 TLR2 MYD88 MUC5AC ITGAX ITGAM
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.81	ITGAX ITGAM IL5 IL1R1 IL1B IL17A
3	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.53	ITGAX ITGAM IL5 IL1R1 IL1B IL17A
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.36	MYD88 ITGAX ITGAM IL5 IL1R1 IL1B
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.29	IL5 IL1R1 IL1B IL17A CCL20 AREG
6	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.21	TLR4 TLR2 MYD88 IL1R1 IL1B IFNGR2
7	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.05	TLR4 TLR2 SFTPD MYD88 IL1B IFNGR2
8	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.9	TLR4 TLR2 MYD88 IL1R1 IL1B
9	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	12.88	TLR4 TLR2 MYD88 ITGAX ITGAM IL5
10	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.84	TLR4 TLR2 MYD88 IL1B IFNGR2 ACTG1
11	Salmonella infection (KEGG) ³⁶ Show member pathways Salmonella infection ³⁶	12.76	TLR4 TLR2 MYD88 IL1R1 IL1B ACTG1
12	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.74	TLR4 TLR2 MYD88 MUC5AC IL1R1 IL1B
13	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.72	TLR4 TLR2 MYD88 IL1R1 IL1B AREG
14	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.6	TLR4 TLR2 MYD88 IL1R1 IL1B
15	NF-kappaB Signaling ⁴	12.52	TLR2 MYD88 IL1B IL17A
16	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.52	TLR4 TLR2 MYD88 IL5 IL1B IL17A
17	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.49	TLR4 TLR2 IL5 IL1R1 IL1B IL17A
18	Shigellosis ³⁶	12.43	TLR4 MYD88 IL1R1 IL1B ACTG1
19	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²³ Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.38	TLR4 TLR2 MYD88 ACTG1
20	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.37	TLR2 MUC5AC IL5 IL1B IL17A CCL20
21	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.35	TLR4 MYD88 IL1R1 IL1B IFNGR2
22	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.25	TLR4 TLR2 MYD88 ITGAM IL1B IFNGR2
23	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.22	IL5 IL1B IL17A AREG
24	Yersinia infection ³⁶	12.1	TLR4 MYD88 IL1B ACTG1
25	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	12.08	TLR4 TLR2 IL5 IL1R1 IL1B
26	Phagosome ³⁶	12.03	TLR4 TLR2 SFTPD MSR1 ITGAM ACTG1
27	Interleukin-4 and 13 signaling ⁶⁵	12.02	ITGAX ITGAM IL1B IL17A
28	NF-kappa B signaling pathway ³⁶	11.98	TLR4 MYD88 IL1R1 IL1B
29	Amoebiasis ³⁶	11.98	TLR4 TLR2 ITGAM IL1R1 IL1B
30	Spinal Cord Injury ¹	11.97	TLR4 IL1R1 IL1B
31	Tuberculosis ³⁶	11.96	TLR4 TLR2 MYD88 ITGAX ITGAM IL1B
32	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.95	ITGAX ITGAM IL5
33	Hematopoietic cell lineage ³⁶	11.94	ITGAM IL5 IL1R1 IL1B
34	Rheumatoid arthritis ³⁶	11.91	TLR4 TLR2 IL1B IL17A CCL20
35	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.89	TLR4 TLR2 IL1R1 IL1B IL17A
36	Phagocytosis of Microbes ⁶³	11.85	TLR4 TLR2 MSR1 ITGAX ITGAM
37	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.84	TLR4 MYD88 IL17A
38	Pertussis ³⁶	11.8	TLR4 MYD88 ITGAM IL1B
39	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.78	ITGAM IL5 IL1R1 IL1B IL17A
40	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.74	ITGAX ITGAM IL1B
41	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.74	TLR4 TLR2 IL1B IL17A IFNGR2
42	IgA-Producing B Cells in the Intestine ⁶⁴	11.69	TLR4 TLR2 IL5
43	Agrin Interactions at Neuromuscular Junction ⁶³	11.62	ITGAX ITGAM ACTG1
44	Malaria ³⁶	11.61	TLR4 TLR2 MYD88 IL1B
45	Transcription_NF-kB signaling pathway ²³	11.59	TLR4 MYD88 IL1R1
46	Interleukin-10 signaling ⁶⁵	11.55	IL1R1 IL1B CCL20
47	Legionellosis ³⁶	11.48	TLR4 TLR2 MYD88 ITGAM IL1B
48	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.44	TLR4 TLR2 SFTPD MYD88 IL1R1 IL1B
49	Development and heterogeneity of the ILC family ¹	11.37	IL5 IL1B IL17A AREG
50	MSP-RON Signaling ⁶³	11.34	TLR4 TLR2 ITGAM IL1B ACTG1

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GO Terms for Silo Filler's Disease

Cellular components related to Silo Filler's Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.63	TLR4 TLR2 ITGAX ITGAM IL1R1 AREG
2	external side of plasma membrane	GO:0009897	9.43	TLR4 MSR1 ITGAX ITGAM IL1R1 IL17A
3	extracellular space	GO:0005615	9.32	SFTPD POTEF MUC5AC ITGAM IL5 IL1B

Biological processes related to Silo Filler's Disease according to GeneCards Suite gene sharing:

(show all 43)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.25	TLR4 TLR2 MYD88 IL5 IL1R1 IL1B
2	immune system process	GO:0002376	10.1	TLR4 TLR2 SFTPD MYD88 ITGAM IL17A
3	innate immune response	GO:0045087	10.02	TLR4 TLR2 SFTPD MYD88 ITGAM IL17A
4	defense response to bacterium	GO:0042742	9.96	TLR4 SFTPD MYD88 CCL20
5	positive regulation of gene expression	GO:0010628	9.95	TLR4 TLR2 MYD88 ITGAX IL1B ACTG1
6	cell-cell signaling	GO:0007267	9.94	IL1B IL17A CCL20 AREG
7	response to lipopolysaccharide	GO:0032496	9.9	TLR4 TLR2 MYD88 IL1B
8	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.89	TLR4 TLR2 MYD88 IL1B
9	immune response	GO:0006955	9.87	TLR4 TLR2 IL5 IL1R1 IL1B IL17A
10	defense response to Gram-positive bacterium	GO:0050830	9.86	TLR2 MYD88 IL17A
11	interleukin-1-mediated signaling pathway	GO:0070498	9.85	MYD88 IL1R1 IL1B
12	positive regulation of inflammatory response	GO:0050729	9.85	TLR4 TLR2 IL1B
13	regulation of inflammatory response	GO:0050727	9.85	TLR4 MYD88 IL1R1
14	positive regulation of JNK cascade	GO:0046330	9.84	TLR4 MYD88 IL1B
15	cellular response to mechanical stimulus	GO:0071260	9.83	TLR4 MYD88 IL1B
16	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.81	TLR4 TLR2 IL1B
17	positive regulation of interferon-gamma production	GO:0032729	9.8	TLR4 IL1R1 IL1B
18	positive regulation of interleukin-12 production	GO:0032735	9.76	TLR4 TLR2 IL17A
19	cellular response to interferon-gamma	GO:0071346	9.76	TLR4 TLR2 CCL20 ACTG1
20	response to interleukin-1	GO:0070555	9.75	MYD88 IL1R1 IL1B
21	positive regulation of chemokine production	GO:0032722	9.74	TLR4 TLR2 MYD88
22	positive regulation of tumor necrosis factor production	GO:0032760	9.73	TLR4 TLR2 MYD88 IL17A
23	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.71	TLR4 TLR2 MYD88
24	positive regulation of interleukin-8 production	GO:0032757	9.71	TLR4 TLR2 MYD88 IL1B
25	microglial cell activation	GO:0001774	9.7	TLR2 ITGAM IFNGR2
26	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.69	TLR4 TLR2
27	positive regulation of keratinocyte proliferation	GO:0010838	9.69	TLR4 AREG
28	amyloid-beta clearance	GO:0097242	9.68	MSR1 ITGAM
29	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.67	TLR4 MYD88
30	I-kappaB phosphorylation	GO:0007252	9.67	TLR4 TLR2
31	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.67	TLR4 MYD88 IL17A
32	toll-like receptor signaling pathway	GO:0002224	9.67	TLR4 TLR2 SFTPD MYD88
33	cellular response to lipoteichoic acid	GO:0071223	9.65	TLR4 TLR2
34	positive regulation of lymphocyte proliferation	GO:0050671	9.64	TLR4 MYD88
35	positive regulation of T-helper 1 cell cytokine production	GO:2000556	9.62	IL1R1 IL1B
36	intestinal epithelial structure maintenance	GO:0060729	9.61	TLR4 IL17A
37	positive regulation of interleukin-23 production	GO:0032747	9.61	MYD88 IL17A
38	positive regulation of matrix metallopeptidase secretion	GO:1904466	9.56	TLR4 TLR2
39	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.56	TLR4 TLR2 MYD88 IL1B
40	inflammatory response	GO:0006954	9.56	TLR4 TLR2 MYD88 IL5 IL1R1 IL1B
41	positive regulation of interleukin-6 production	GO:0032755	9.55	TLR4 TLR2 MYD88 IL1B IL17A
42	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.51	TLR4 TLR2
43	cytokine-mediated signaling pathway	GO:0019221	9.28	MYD88 ITGAX ITGAM IL5 IL1R1 IL1B

Molecular functions related to Silo Filler's Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.33	TLR4 TLR2 SFTPD POTEF MYD88 MUC5AC
2	cytokine activity	GO:0005125	9.65	IL5 IL1B IL17A CCL20 AREG
3	cargo receptor activity	GO:0038024	9.46	MSR1 ITGAM
4	amyloid-beta binding	GO:0001540	9.46	TLR4 TLR2 MSR1 ITGAM
5	interleukin-1 receptor binding	GO:0005149	9.43	MYD88 IL1B
6	Toll-like receptor binding	GO:0035325	9.37	TLR2 MYD88
7	lipopolysaccharide receptor activity	GO:0001875	9.32	TLR4 TLR2
8	NAD+ nucleotidase, cyclic ADP-ribose generating	GO:0061809	9.13	TLR4 TLR2 IL1R1
9	NAD(P)+ nucleosidase activity	GO:0050135	8.8	TLR4 TLR2 IL1R1

Sources

Sources for Silo Filler's Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia