MCID: SML010
MIFTS: 32

Simultanagnosia

Categories: Eye diseases, Mental diseases, Rare diseases

Aliases & Classifications for Simultanagnosia

MalaCards integrated aliases for Simultanagnosia:

Name: Simultanagnosia 12 20 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060148

Summaries for Simultanagnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to recgonize a whole image or scene while retianing the ability to recognize objects or details in their visual field one at a time.

MalaCards based summary : Simultanagnosia is related to posterior cortical atrophy and apraxia. An important gene associated with Simultanagnosia is ABCA7 (ATP Binding Cassette Subfamily A Member 7), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Notch Signaling Pathway (WikiPathways). Affiliated tissues include brain, parietal lobe and eye, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 73 Simultanagnosia (or simultagnosia) is a rare neurological disorder characterized by the inability of an... more...

Related Diseases for Simultanagnosia

Diseases related to Simultanagnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 posterior cortical atrophy 30.4 MAPT APOE
2 apraxia 30.1 PSEN1 MAPT APOE
3 dysgraphia 30.0 TARDBP MAPT
4 anosognosia 29.9 PSEN1 APOE
5 brain injury 29.8 MAPT APOE
6 prosopagnosia 29.6 TARDBP PSEN2 MAPT
7 hydrocephalus 29.6 PSEN1 MAPT APOE
8 visual agnosia 29.2 PSEN2 PSEN1 PCAT2 MAPT APOE
9 alexia 29.0 TARDBP PSEN2 PCAT2 MAPT APOE ABCA7
10 agraphia 29.0 TARDBP PCAT2 MAPT APOE ACHE
11 nominal aphasia 28.1 TARDBP PSEN1 PCAT2 MAPT APOE ACHE
12 alzheimer disease 27.7 TARDBP PSEN2 PSEN1 MAPT BIN1 APOE
13 balint syndrome 11.0
14 ataxia and polyneuropathy, adult-onset 10.2
15 subjective cognitive decline 10.2 MAPT APOE
16 age-related hearing loss 10.1 MAPT APOE
17 finger agnosia 10.1 PCAT2 MAPT
18 mild cognitive impairment 10.1 MAPT APOE
19 agnosia 10.1
20 progressive non-fluent aphasia 10.0 PSEN1 MAPT
21 oculomotor apraxia 10.0
22 cerebral amyloid angiopathy, itm2b-related, 1 10.0 PSEN2 PSEN1
23 cerebral amyloid angiopathy, app-related 9.9 PSEN2 PSEN1 APOE
24 alzheimer disease 9 9.9 PSEN1 MAPT ABCA7
25 alzheimer disease 3 9.9 PSEN2 PSEN1 APOE
26 associative agnosia 9.9 TARDBP MAPT
27 gerstmann-straussler disease 9.9 PSEN2 PSEN1 MAPT
28 pica disease 9.9 TARDBP MAPT
29 communicating hydrocephalus 9.9 PSEN1 MAPT APOE
30 chromosomal disease 9.9 PSEN2 PSEN1 APOE
31 akinetic mutism 9.9 TARDBP MAPT
32 normal pressure hydrocephalus 9.9 PSEN1 MAPT APOE
33 mutism 9.9 TARDBP MAPT
34 postencephalitic parkinson disease 9.9 TARDBP MAPT
35 writing disorder 9.9 TARDBP MAPT
36 alzheimer disease 10 9.9 MAPT APOE ACHE
37 binswanger's disease 9.8 MAPT APOE ACHE
38 frontotemporal dementia and/or amyotrophic lateral sclerosis 7 9.8 TARDBP MAPT
39 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.8
40 yemenite deaf-blind hypopigmentation syndrome 9.8
41 brugada syndrome 9.8
42 cone dystrophy 9.8
43 autotopagnosia 9.8
44 cardiac arrest 9.8
45 obstructive hydrocephalus 9.8
46 posterior cerebral artery infarction 9.8
47 cerebral atrophy 9.8
48 encephalopathy 9.8
49 hypoxia 9.8
50 neonatal hypoxic and ischemic brain injury 9.8

Graphical network of the top 20 diseases related to Simultanagnosia:



Diseases related to Simultanagnosia

Symptoms & Phenotypes for Simultanagnosia

MGI Mouse Phenotypes related to Simultanagnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ABCA7 ACHE APOE BIN1 MAPT PSEN1
2 cardiovascular system MP:0005385 9.87 ABCA7 ACHE APOE BIN1 MAPT PSEN1
3 homeostasis/metabolism MP:0005376 9.86 ABCA7 ACHE APOE BIN1 MAPT PSEN1
4 muscle MP:0005369 9.63 ACHE APOE BIN1 MAPT PSEN1 TARDBP
5 nervous system MP:0003631 9.5 ABCA7 ACHE APOE MAPT PSEN1 PSEN2
6 renal/urinary system MP:0005367 9.02 ABCA7 APOE MAPT PSEN1 PSEN2

Drugs & Therapeutics for Simultanagnosia

Search Clinical Trials , NIH Clinical Center for Simultanagnosia

Genetic Tests for Simultanagnosia

Anatomical Context for Simultanagnosia

MalaCards organs/tissues related to Simultanagnosia:

40
Brain, Parietal Lobe, Eye, Cortex

Publications for Simultanagnosia

Articles related to Simultanagnosia:

(show top 50) (show all 157)
# Title Authors PMID Year
1
Teaching Video NeuroImages: Posterior Cortical Atrophy Presenting With Balint Syndrome. 61
32928969 2021
2
Temporo-parietal brain regions are involved in higher order object perception. 61
33757908 2021
3
18F-FDG PET/CT in the Diagnosis and Follow-up of Balint Syndrome. 61
33065619 2021
4
Posterior Cortical Atrophy phenotype in a GBA N370S mutation carrier: a case report. 61
33435912 2021
5
Who is really blind in the time of coronavirus: the patient or the doctor? A rare case of Balint's syndrome. 61
33400067 2021
6
Clinical and radiological features of posterior cortical atrophy (PCA) in a GRN mutation carrier: a case report. 61
33030763 2021
7
Superior Parietal Lobule: A Role in Relative Localization of Multiple Different Elements. 61
32959044 2021
8
Asymmetric Bálint's syndrome with multimodal agnosia, bilateral agraphesthesia, and ineffective kinesthetic reading due to subcortical hemorrhage in the left parieto-occipito-temporal area. 61
33103577 2020
9
Impaired mechanism of visual focal attention in posterior cortical atrophy. 61
32940497 2020
10
Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy. 61
32897377 2020
11
The Birthday Party Test (BPT); A new picture description test to support the assessment of simultanagnosia in patients with acquired brain injury. 61
32476466 2020
12
Impaired spatial processing in visual perception, imagery and art-making following parieto-occipital infarcts. 61
32171493 2020
13
[Visual impairment following a suicide attempt with a crossbow]. 61
32073797 2020
14
Simultanagnosia as the presenting symptom in neuro-ophthalmology. 61
32063790 2020
15
Simultanagnosia as a cause of visual disturbance following Posterior Reversible Encephalopathy Syndrome (PRES): A case report. 61
31856545 2020
16
Three-systems for visual numerosity: A single case study. 61
31726066 2020
17
Balint syndrome (chronic visual-spatial disorder) presenting without known cause. 61
30258515 2018
18
The Visual Agnosias and Related Disorders. 61
28945627 2018
19
Ocular Dysfunctions Presenting in Tacrolimus-Induced Posterior Reversible Encephalopathy Syndrome: A Case Presentation. 61
28911995 2018
20
Bilateral parietal dysfunctions and disconnections in simultanagnosia and Bálint syndrome. 61
29519461 2018
21
Asymmetric oculomotor apraxia, optic ataxia, and simultanagnosia with right hemispatial neglect from a predominantly left-sided lesion of the parieto-occipital area. 61
29199507 2018
22
Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease. 61
29614676 2018
23
Visual and cross-modal cues increase the identification of overlapping visual stimuli in Balint's syndrome. 61
28078966 2017
24
Simultanagnosia and object individuation. 61
28632043 2017
25
Gerstmann's syndrome and unilateral optic ataxia in the emergency department. 61
29354229 2017
26
Simultaneous object perception deficits are related to reduced visual processing speed in amnestic mild cognitive impairment. 61
28438484 2017
27
Simultanagnosia does not affect processes of auditory Gestalt perception. 61
28343958 2017
28
A 63-Year-Old Man With Progressive Visual Symptoms. 61
27842190 2017
29
Visual Dysfunction in Posterior Cortical Atrophy. 61
28861031 2017
30
Neuro-cognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy. 61
27702740 2016
31
Patterns of frontoparietal activation as a marker for unsuccessful visuospatial processing in healthy aging. 61
26195153 2016
32
Stimulus size mediates Gestalt processes in object perception - evidence from simultanagnosia. 61
27267104 2016
33
Seeing red: Relearning to read in a case of Balint's Syndrome. 61
27341365 2016
34
Simultanagnosia: when all you can see are trees, the forest still rules. 61
26878160 2016
35
Here, there and everywhere: higher visual function and the dorsal visual stream. 61
26786007 2016
36
Adult-onset phenylketonuria with rapidly progressive dementia and parkinsonism. 61
26962957 2016
37
Double Disassociation of Anosognosia for Alexia and Simultanagnosia but Quantitative Awareness of Optic Ataxia. 61
26368835 2016
38
The Attentional Fields of Visual Search in Simultanagnosia and Healthy Individuals: How Object and Space Attention Interact. 61
25840422 2016
39
Ventral simultanagnosia and prosopagnosia for unfamiliar faces due to a right posterior superior temporal sulcus and angular gyrus lesion. 61
26207875 2016
40
Pediatric Balint's Syndrome Variant: A Possible Diagnosis in Children. 61
27895948 2016
41
Involvement of the TPJ area in processing of novel global forms. 61
25811709 2015
42
[Posterior cortical atrophy. Pathology, diagnosis and treatment of a rare form of dementia]. 61
25791802 2015
43
Clinical, FDG and amyloid PET imaging in posterior cortical atrophy. 61
25862483 2015
44
Visual signs and symptoms in patients with the visual variant of Alzheimer disease. 61
26122482 2015
45
Combination of attentional and spatial working memory deficits in Bálint-Holmes syndrome. 61
25708555 2015
46
Holmes and Horrax (1919) revisited: impaired binocular fusion as a cause of "flat vision" after right parietal brain damage - a case study. 61
25619849 2015
47
[Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report]. 61
26369377 2015
48
Clinical TVA-based studies: a general review. 61
25852607 2015
49
Abnormal center-periphery gradient in spatial attention in simultanagnosia. 61
24893736 2014
50
Higher cortical visual deficits. 61
25099101 2014

Variations for Simultanagnosia

Expression for Simultanagnosia

Search GEO for disease gene expression data for Simultanagnosia.

Pathways for Simultanagnosia

GO Terms for Simultanagnosia

Cellular components related to Simultanagnosia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.89 PSEN2 PSEN1 APOE ACHE ABCA7
2 cell surface GO:0009986 9.78 PSEN2 PSEN1 ACHE ABCA7
3 dendrite GO:0030425 9.71 PSEN1 MAPT BIN1 APOE
4 membrane raft GO:0045121 9.7 PSEN2 PSEN1 MAPT
5 growth cone GO:0030426 9.61 PSEN2 PSEN1 MAPT
6 Z disc GO:0030018 9.54 PSEN2 PSEN1 BIN1
7 dendritic shaft GO:0043198 9.51 PSEN2 PSEN1
8 synaptic cleft GO:0043083 9.46 APOE ACHE
9 neuronal cell body GO:0043025 9.46 PSEN2 PSEN1 MAPT APOE
10 glial cell projection GO:0097386 9.32 MAPT ABCA7
11 ciliary rootlet GO:0035253 9.26 PSEN2 PSEN1
12 gamma-secretase complex GO:0070765 8.96 PSEN2 PSEN1
13 neuromuscular junction GO:0031594 8.8 PSEN2 PSEN1 ACHE

Biological processes related to Simultanagnosia according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.76 TARDBP PSEN1 MAPT APOE
2 regulation of synaptic plasticity GO:0048167 9.62 PSEN1 MAPT
3 positive regulation of protein import into nucleus GO:0042307 9.62 TARDBP PSEN1
4 positive regulation of catalytic activity GO:0043085 9.61 PSEN2 PSEN1
5 cholesterol efflux GO:0033344 9.61 APOE ABCA7
6 memory GO:0007613 9.61 PSEN1 MAPT ABCA7
7 positive regulation of dendritic spine development GO:0060999 9.6 PSEN1 APOE
8 membrane protein ectodomain proteolysis GO:0006509 9.59 PSEN2 PSEN1
9 membrane protein intracellular domain proteolysis GO:0031293 9.58 PSEN2 PSEN1
10 positive regulation of cholesterol efflux GO:0010875 9.58 APOE ABCA7
11 astrocyte activation GO:0048143 9.57 PSEN1 MAPT
12 amyloid-beta metabolic process GO:0050435 9.56 PSEN2 PSEN1
13 amyloid precursor protein catabolic process GO:0042987 9.55 PSEN2 PSEN1
14 high-density lipoprotein particle assembly GO:0034380 9.54 APOE ABCA7
15 phospholipid efflux GO:0033700 9.52 APOE ABCA7
16 Notch receptor processing GO:0007220 9.51 PSEN2 PSEN1
17 positive regulation of amyloid-beta clearance GO:1900223 9.49 APOE ABCA7
18 Notch receptor processing, ligand-dependent GO:0035333 9.48 PSEN2 PSEN1
19 gene expression GO:0010467 9.43 TARDBP PSEN1 APOE
20 positive regulation of amyloid fibril formation GO:1905908 9.4 PSEN1 APOE
21 positive regulation of phospholipid efflux GO:1902995 9.37 APOE ABCA7
22 negative regulation of amyloid-beta formation GO:1902430 9.33 BIN1 APOE ABCA7
23 regulation of amyloid precursor protein catabolic process GO:1902991 9.32 APOE ABCA7
24 amyloid precursor protein metabolic process GO:0042982 9.13 PSEN1 APOE ACHE
25 amyloid-beta formation GO:0034205 8.8 PSEN2 PSEN1 ABCA7

Molecular functions related to Simultanagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 TARDBP MAPT BIN1 APOE ACHE
2 tau protein binding GO:0048156 9.37 BIN1 APOE
3 lipid transporter activity GO:0005319 9.26 APOE ABCA7
4 aspartic-type endopeptidase activity GO:0004190 9.16 PSEN2 PSEN1
5 lipoprotein particle binding GO:0071813 8.96 MAPT APOE
6 aspartic endopeptidase activity, intramembrane cleaving GO:0042500 8.62 PSEN2 PSEN1

Sources for Simultanagnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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