Sinoatrial Node Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SNT005 MIFTS: 44	Sinoatrial Node Disease Categories: Cardiovascular diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Sinoatrial Node Disease

MalaCards integrated aliases for Sinoatrial Node Disease:

Name: Sinoatrial Node Disease ¹² ¹⁵

Sinus Node Dysfunction ⁷³

Sinuatrial Node ¹²

Sa Node ¹²

Classifications:

MalaCards categories:
Anatomical: Muscle diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050824

UMLS ⁷³ C0428908

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Summaries for Sinoatrial Node Disease

Disease Ontology : ¹² A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.

MalaCards based summary : Sinoatrial Node Disease, also known as sinus node dysfunction, is related to sick sinus syndrome and third-degree atrioventricular block. An important gene associated with Sinoatrial Node Disease is SHOX2 (Short Stature Homeobox 2), and among its related pathways/superpathways are G-Beta Gamma Signaling and Myometrial Relaxation and Contraction Pathways. The drugs Propafenone and Sotalol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : ⁷⁶ The sinoatrial node (SA node), also known as sinus node, is a group of cells located in the wall of the... more...

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Related Diseases for Sinoatrial Node Disease

Diseases related to Sinoatrial Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	sick sinus syndrome	32.2	HCN4 MYH6 SCN5A SHOX2
2	third-degree atrioventricular block	32.0	HCN4 SCN5A
3	multifocal atrial tachycardia	11.3
4	atrioventricular block	11.2
5	long qt syndrome 9	10.1	HCN4 SCN5A
6	atrial standstill	10.1	GJA5 SCN5A
7	progressive familial heart block	10.1	GJA5 SCN5A
8	progressive familial heart block, type ia	10.1	GJA5 SCN5A
9	right bundle branch block	10.1	HCN4 SCN5A
10	ulnar-mammary syndrome	10.0	TBX18 TBX3
11	familial sick sinus syndrome	10.0	HCN4 MYH6 SCN5A
12	first-degree atrioventricular block	10.0	GJA5 GJC1 SCN5A
13	holt-oram syndrome	10.0	MYH6 SHOX2 TBX3
14	lymphoma	10.0
15	syncope	10.0
16	left ventricular noncompaction	10.0	HCN4 MYH6 SCN5A
17	atrial standstill 1	10.0	GJA5 MYH6 SCN5A
18	axenfeld-rieger syndrome	10.0	GJA1 SHOX2
19	oculodentodigital dysplasia	9.9	GJA1 GJA5 GJC1
20	arrhythmogenic right ventricular cardiomyopathy	9.9	GJA1 HCN4 SCN5A
21	familial isolated dilated cardiomyopathy	9.9	MYH6 SCN5A
22	achondroplasia	9.9
23	heart conduction disease	9.8	GJA1 GJA5 HCN4 SCN5A SHOX2
24	atrial fibrillation	9.7	GJA1 GJA5 HCN4 SCN5A SHOX2
25	heart disease	9.7	GJA1 GJA5 HCN4 MYH6 SCN5A
26	dilated cardiomyopathy	9.7	GJA1 GJA5 MYH6 SCN5A

Comorbidity relations with Sinoatrial Node Disease via Phenotypic Disease Network (PDN): (show all 50)

Acute Cystitis	Acute Kidney Failure
Anxiety	Aortic Valve Disease 1
Atrioventricular Block	Basilar Artery Insufficiency
Benign Essential Hypertension	Bronchitis
Cardiac Arrest	Cardiac Arrhythmia
Cerebral Atherosclerosis	Cerebrovascular Disease
Chronic Kidney Failure	Chronic Myocardial Ischemia
Deficiency Anemia	Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis	Familial Atrial Fibrillation
First-Degree Atrioventricular Block	Generalized Atherosclerosis
Gout	Heart Disease
Hypertension, Essential	Hypertrophic Cardiomyopathy
Hypoglycemia	Hypothyroidism
Idiopathic Peripheral Autonomic Neuropathy	Intermediate Coronary Syndrome
Intracranial Embolism	Ischemic Heart Disease
Kidney Disease	Left Bundle Branch Hemiblock
Malignant Essential Hypertension	Mitral Valve Disease
Mitral Valve Stenosis	Mobitz Type Ii Atrioventricular Block
Monocular Esotropia	Nutmeg Liver
Peripheral Vascular Disease	Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1	Pulmonary Valve Disease
Rheumatic Heart Disease	Right Bundle Branch Block
Schizophreniform Disorder	Third-Degree Atrioventricular Block
Transient Cerebral Ischemia	Tricuspid Valve Disease
Ventricular Fibrillation, Paroxysmal Familial, 1	Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Sinoatrial Node Disease:

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Symptoms & Phenotypes for Sinoatrial Node Disease

MGI Mouse Phenotypes related to Sinoatrial Node Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.1	CYP27B1 GJA1 GJA5 GJC1 HCN2 HCN4
2	growth/size/body region	MP:0005378	9.76	CYP27B1 GJA1 GJC1 HCN2 SCN5A SHOX2
3	craniofacial	MP:0005382	9.65	CYP27B1 GJA1 SHOX2 TBX18 TBX3
4	mortality/aging	MP:0010768	9.65	GJA1 GJA5 GJC1 HCN2 HCN4 MYH6
5	muscle	MP:0005369	9.28	CYP27B1 GJA1 GJA5 GJC1 HCN4 MYH6

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Drugs & Therapeutics for Sinoatrial Node Disease

Drugs for Sinoatrial Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Propafenone

Approved

Phase 4

54063-53-5

4932

Sotalol

Approved

Phase 4

959-24-0, 3930-20-9

5253

Amiodarone

Approved, Investigational

Phase 4

1951-25-3

2157

Atenolol

Approved

Phase 4

29122-68-7

2249

Nebivolol

Approved, Investigational

Phase 4

99200-09-6, 152520-56-4, 118457-14-0

71301

Ethanol

Approved

Phase 4

64-17-5

702

Metoprolol

Approved, Investigational

Phase 4

37350-58-6, 51384-51-1

4171

Cytochrome P-450 CYP1A2 Inhibitors

Phase 4,Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3

Sodium Channel Blockers

Phase 4

Adrenergic Agents

Phase 4

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4

Diuretics, Potassium Sparing

Phase 4

Autonomic Agents

Phase 4

Anti-Arrhythmia Agents

Phase 4,Not Applicable

Adrenergic beta-Antagonists

Phase 4

Cytochrome P-450 CYP2D6 Inhibitors

Phase 4

Peripheral Nervous System Agents

Phase 4

Potassium Channel Blockers

Phase 4

Neurotransmitter Agents

Phase 4

Cytochrome P-450 CYP3A Inhibitors

Phase 4

Vasodilator Agents

Phase 4

Sympatholytics

Phase 4

Adrenergic Antagonists

Phase 4

Antihypertensive Agents

Phase 4,Not Applicable

Adrenergic beta-Agonists

Phase 4

Adrenergic beta-1 Receptor Antagonists

Phase 4

Adrenergic Agonists

Phase 4

Clindamycin

Approved, Vet_approved

Phase 3

18323-44-9

29029

Levofloxacin

Approved, Investigational

Phase 3

100986-85-4

149096

Ofloxacin

Approved

Phase 3

82419-36-1

4583

Bacitracin

Approved, Vet_approved

Phase 3

1405-87-4

10909430 439542

Cephalexin

Approved, Investigational, Vet_approved

Phase 3

15686-71-2

27447

Topoisomerase Inhibitors

Phase 3

Polymyxins

Phase 3

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents, Local

Phase 3

Renal Agents

Phase 3

Anti-Infective Agents

Phase 3

Clindamycin palmitate

Phase 3

Clindamycin phosphate

Phase 3

Polymyxin B

Phase 3

Antibiotics, Antitubercular

Phase 3

Anti-Infective Agents, Urinary

Phase 3

Antitubercular Agents

Phase 3

Angiotensin II

Approved, Investigational

,Not Applicable

11128-99-7, 68521-88-0, 4474-91-3

172198 65143

Losartan

Approved

Not Applicable

114798-26-4

3961

tannic acid

Approved

Not Applicable

Benzocaine

Approved, Investigational

Not Applicable

94-09-7, 1994-09-7

2337

Digoxin

Approved

20830-75-5

30322 2724385

Interventional clinical trials:

(show top 50) (show all 66)

#	Name	Status	NCT ID	Phase	Drugs
1	Mode Evaluation in Sick Sinus Syndrome Trial (MODEST)	Unknown status	NCT00161551	Phase 4
2	Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation	Unknown status	NCT00224341	Phase 4
3	Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity.	Unknown status	NCT00156741	Phase 4
4	Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation	Unknown status	NCT02145546	Phase 4	Amiodarone;Propafenone;Sotalol
5	Syncope: Pacing or Recording in the Later Years	Unknown status	NCT01423994	Phase 4
6	The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker	Completed	NCT03245996	Phase 4	Atenolol Pill;Nebivolol Pill;Ivabradine Pill
7	Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation	Completed	NCT00161538	Phase 4
8	Austria Study - Analysis of Difference Between Active and Passive Fixation Leads	Completed	NCT00180557	Phase 4
9	Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease	Completed	NCT01170611	Phase 4
10	Falls and Cardiovascular Events in Pacemaker Patients	Completed	NCT01037426	Phase 4
11	Spontaneous Atrio Ventricular Conduction Preservation	Completed	NCT00655213	Phase 4
12	Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease	Recruiting	NCT03566667	Phase 4	Metoprolol;Standard care
13	Virtual Clinic Pacemaker Follow-up	Terminated	NCT00475124	Phase 4
14	Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation	Completed	NCT02317068	Phase 3
15	Mode Selection Trial in Sinus Node Dysfunction (MOST)	Completed	NCT00000561	Phase 3
16	Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.	Recruiting	NCT02809131	Phase 3	polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
17	The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome	Terminated	NCT00236158	Phase 2, Phase 3
18	Second Study on Cardio-neuromodulation in Humans	Unknown status	NCT02954666	Phase 2
19	RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome	Unknown status	NCT01477138
20	The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome	Unknown status	NCT01310920
21	The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome	Unknown status	NCT00647257	Not Applicable	Losartan;Placebo
22	Left Ventricular Function and Remodelling During Permanent Pacing	Unknown status	NCT00228241	Not Applicable
23	Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan	Unknown status	NCT00314223
24	Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position	Unknown status	NCT01647490	Not Applicable
25	Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance	Unknown status	NCT01798043	Not Applicable
26	Minimizing Ventricular Pacing	Unknown status	NCT01611389	Not Applicable
27	Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study	Completed	NCT01528657	Not Applicable
28	Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)	Completed	NCT00785564
29	Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot	Completed	NCT02198781
30	Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing	Completed	NCT00286858
31	The Atrial High Rate Episodes in Pacemaker Patients	Completed	NCT00627328
32	Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class	Completed	NCT00292539
33	Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum	Completed	NCT01609738
34	SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction	Completed	NCT00284830	Not Applicable
35	Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study)	Completed	NCT00664807
36	DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.	Completed	NCT00478933	Not Applicable
37	Brady MX a Quality Improvement Study	Completed	NCT02976181
38	To Pace or Not to Pace in Sinus Node Disease	Completed	NCT02485093	Not Applicable
39	A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction	Completed	NCT02027909
40	Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing	Completed	NCT01803217	Not Applicable
41	Right Ventricular Outflow Tract Study	Completed	NCT01294839	Not Applicable
42	Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PATCH-ED)	Completed	NCT02683174	Not Applicable
43	Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode	Completed	NCT02586480
44	Ingenio Device Algorithm Study	Completed	NCT01441583	Not Applicable
45	IES-ACap: Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm.	Completed	NCT00832260
46	PANORAMA Observational Study	Completed	NCT00382525
47	Real Life Automatic Atrial Capture Device Control	Completed	NCT02400983
48	Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome.	Recruiting	NCT02034526	Not Applicable
49	Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study	Recruiting	NCT02314897	Not Applicable
50	Left Ventricular Pacing to Avoid Cardiac Enlargement Study	Recruiting	NCT01302717	Not Applicable

Search NIH Clinical Center for Sinoatrial Node Disease

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Genetic Tests for Sinoatrial Node Disease

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Anatomical Context for Sinoatrial Node Disease

MalaCards organs/tissues related to Sinoatrial Node Disease:

⁴¹

Heart, Testes, Atrioventricular Node

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Publications for Sinoatrial Node Disease

Articles related to Sinoatrial Node Disease:

(show top 50) (show all 301)

#	Title	Authors	Year
1	Sinoatrial Node Disease in Adults with Down's Syndrome. ( 29588556 )	Kennedy J....McGlinchey P.G.	2018
2	Sinus node dysfunction after surgical atrial fibrillation ablation with concomitant mitral valve surgery: Determinants and clinical outcomes. ( 30208099 )	Kim D...Chang BC	2018
3	Interleukin-10 Treatment Attenuates Sinus Node Dysfunction Caused by Streptozotocin-induced Hyperglycemia in Mice. ( 29982291 )	Kondo H...Takahashi N	2018
4	Unifocal Right-Sided Ablation Treatment for Neurally Mediated Syncope and Functional Sinus Node Dysfunction Under Computed Tomographic Guidance. ( 30354289 )	Debruyne P...Wijns W	2018
5	Sinus node dysfunction after heart transplantation-An analysis of risk factors and atrial pacing burden. ( 29345729 )	Herrmann FEM...Juchem G	2018
6	Catheter ablation of the slow pathway as a treatment for severe sinus node dysfunction in a patient with incessant atrioventricular nodal reentry tachycardia. ( 29707487 )	Margolis G...Belhassen B	2018
7	A case of atenolol-induced sinus node dysfunction presenting as escape-capture bigeminy. ( 29868180 )	Manne JRR	2018
8	Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement. ( 30275471 )	Tomomori S...Kihara Y	2018
9	Prevalence and predictors of atrial arrhythmias in patients with sinus node dysfunction and atrial pacing. ( 30293095 )	Bukari A...Ozcan C	2018
10	Guillain-Barré Syndrome Presenting with Sinus Node Dysfunction and Refractory Shock. ( 28283677 )	Ha LD...Rao M	2017
11	Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction. ( 27702858 )	Brenner R...K?hne M	2017
12	Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon? ( 28155995 )	Jackson LR...Daubert JP	2017
13	Pacing Discovery: G-Protein β Subunit Mutations in Sinus Node Dysfunction. ( 28495981 )	Lodder EM...Bezzina CR	2017
14	Under-utilization of pacemaker therapy for sinus node dysfunction - Real world data from South Asia. ( 29054184 )	Narasimhan C...Naik A	2017
15	Rapidly progressive cardiac sarcoidosis: Initial presentation with sinus node dysfunction and right bundle branch block. ( 28491632 )	Aldweib N...Thosani AJ	2016
16	Simplified Cardioneuroablation in the Treatment of Reflex Syncope, Functional AV Block, and Sinus Node Dysfunction. ( 26411271 )	Aksu T...Erden I	2016
17	Cardiac pacing strategies and post-implantation risk of atrial fibrillation and heart failure events in sinus node dysfunction patients: a collaborative analysis of over 6000 patients. ( 26913516 )	Chen S...P?rerfellner H	2016
18	Sinus Node Dysfunction After Extracardiac Conduit and Lateral Tunnel Fontan Operation: The Importance of the Type of Prior Superior Cavopulmonary Anastomosis. ( 26957405 )	Rajanbabu BB...Gangopadhyay D	2016
19	Acute Sinus Node Dysfunction after Atrial Ablation: Incidence, Risk Factors, and Management. ( 27530090 )	Killu AM...Mulpuru SK	2016
20	Sinus Node Dysfunction: A Rare Side Effect of Tigecyclin. ( 27766826 )	Agarwal M...Bhushan D	2016
21	Transvenous approach to pacemaker lead implantation for sinus node dysfunction after extracardiac lateral tunnel Fontan conduit placement. ( 28491745 )	O'Leary E...Mah D	2016
22	Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction. ( 26282245 )	Chen J...Kimura T	2016
23	Transient sinus node dysfunction following sinus node artery occlusion due to radiofrequency catheter ablation of the septal superior vena cava-right atrium junction. ( 26607406 )	Kitamura T...Hiraoka M	2016
24	Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry. ( 26720750 )	Jackson LR...Kowey PR	2016
25	Warning leak of intracranial aneurysm masquerading as sinus node dysfunction: A case report. ( 27489696 )	Bisht DS...Garg N	2015
26	Sinus Node Dysfunction After Acute Lithium Treatment at Therapeutic Levels. ( 27222761 )	Nakamura M...Nagamine T	2015
27	Sinus node dysfunction complicating viper bite. ( 24887872 )	Agarwal A...Agarwal N	2015
28	Ankyrin-B syndrome: a case of sinus node dysfunction, atrial fibrillation and prolonged QT in a young adult. ( 25456501 )	Robaei D...Ooi SY	2015
29	Sinus node dysfunction requiring permanent pacemaker implantation in a young adult with Klinefelter syndrome. ( 25744562 )	Karag?z A...Bekta? O	2015
30	Side effects of ticagrelor: Sinus node dysfunction with ventricular pause. ( 25965599 )	Nicol M...Mansencal N	2015
31	A low fibrillatory wave amplitude predicts sinus node dysfunction after catheter ablation in patients with persistent atrial fibrillation. ( 26003808 )	Sunaga A...Uematsu M	2015
32	Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction. ( 26044937 )	Heijman J...Dobrev D	2015
33	CHA2DS2-VAS(C) and CHADS2 Scores Predict Adverse Clinical Events in Patients With Pacemakers and Sinus Node Dysfunction Independent of Atrial Fibrillation. ( 26076964 )	Glotzer TV...Lamas GA	2015
34	It's all in your head: sinus node dysfunction secondary to a sphenoid wing meningioma. ( 26141412 )	Rivinius R...Schweizer PA	2015
35	Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. ( 26770873 )	An M...Kim M	2015
36	H1N1-associated sinus node dysfunction. ( 27326207 )	Steinberg C...Chakrabarti S	2015
37	Exome sequencing identifies a novel mutation in the MYH6 gene in a family with early-onset sinus node dysfunction, ventricular arrhythmias, and cardiac arrest. ( 28491533 )	Lam L...Semsarian C	2015
38	Fibrosis, electrics and genetics. Perspectives in sinoatrial node disease. ( 24837708 )		2014
39	Severe sinus node dysfunction in a patient with juvenile neuronal ceroid lipofuscinosis. ( 24726208 )	Dilaveris P...Stefanadis C	2014
40	Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial. ( 24797760 )	Holmqvist F...MOST investigators	2014
41	Sinus node dysfunction after partial anomalous pulmonary venous connection repair. ( 24060362 )	Pace Napoleone C...Gargiulo GD	2014
42	Should catheter ablation be the preferred approach for treatment of atrial fibrillation related symptomatic sinus node dysfunction? ( 24456425 )	Calkins H	2014
43	The type of sinus node dysfunction might predict the severity of atrial remodeling and clinical outcome after catheter ablation of atrial fibrillation. ( 24512882 )	Chung H...Joung B	2014
44	Relationship between two arrhythmias: sinus node dysfunction and atrial fibrillation. ( 24825742 )	Zhao J...Li G	2014
45	Sinus node dysfunction and atrial fibrillation: which one dominates? ( 24912808 )	Amasyali B...Kilit C	2014
46	Extracardiac autologous pericardial tunnel Fontan allows implantation of an endocardial atrial lead for sinus node dysfunction. ( 25193196 )	Newcombe J...Mandapati R	2014
47	Concealed Sinus Node Dysfunction and Paradoxical Effect of Atropine during Arrhythmia Diagnostic Pharmacological Testing. ( 25232283 )	Karam M...Kossaify A	2014
48	Fetal bradycardia and sinus node dysfunction. ( 22639004 )	Bravo-Valenzuela NJ	2013
49	Sinus node dysfunction in atrial fibrillation patients: the evidence of regional atrial substrate remodelling. ( 22772055 )	Chang HY...Chen SA	2013
50	Sinus node dysfunction and atrial fibrillation: two sides of the same coin? ( 22906746 )	Lee JM...Kalman JM	2013

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Genes for Sinoatrial Node Disease

Genes related to Sinoatrial Node Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SHOX2	Short Stature Homeobox 2	Protein Coding	20.23	DISEASES inferred ¹⁵ ¹⁵
2	HCN4	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4	Protein Coding	18.46	DISEASES inferred ¹⁵
3	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	17.82	DISEASES inferred ¹⁵
4	GJC1	Gap Junction Protein Gamma 1	Protein Coding	16.42	DISEASES inferred ¹⁵
5	TBX3	T-Box 3	Protein Coding	16.38	DISEASES inferred ¹⁵
6	TBX18	T-Box 18	Protein Coding	16.2	DISEASES inferred ¹⁵
7	GJA5	Gap Junction Protein Alpha 5	Protein Coding	16.06	DISEASES inferred ¹⁵
8	MYH6	Myosin Heavy Chain 6	Protein Coding	15.92	DISEASES inferred ¹⁵
9	HCN2	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium And Sodium Channel 2	Protein Coding	15.54	DISEASES inferred ¹⁵
10	KCNJ3	Potassium Voltage-Gated Channel Subfamily J Member 3	Protein Coding	15.52	DISEASES inferred ¹⁵
11	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	15.08	DISEASES inferred ¹⁵
12	GJA1	Gap Junction Protein Alpha 1	Protein Coding	14.97	DISEASES inferred ¹⁵

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Variations for Sinoatrial Node Disease

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Expression for Sinoatrial Node Disease

Search GEO for disease gene expression data for Sinoatrial Node Disease.

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Pathways for Sinoatrial Node Disease

Pathways related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴ Hedgehog Signaling in Mammals ⁶⁴ Relaxin Pathway ⁶⁴ Signaling in Gap Junctions ⁶⁴	12.59	GJA1 GJA5 GJC1 KCNJ3 SCN5A
2	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	11.95	GJA1 GJA5 GJC1 KCNJ3
3	Potassium Channels ⁶⁶ Show member pathways HCN channels ⁶⁶ Voltage gated Potassium channels ⁶⁶	11.71	HCN2 HCN4 KCNJ3
4	Gap junction trafficking ⁶⁶ Show member pathways Entry of Influenza Virion into Host Cell via Endocytosis ⁶⁶ Formation of annular gap junctions ⁶⁶ Gap junction assembly ⁶⁶ Gap junction degradation ⁶⁶ Gap junction trafficking and regulation ⁶⁶	11.42	GJA1 GJA5 GJC1
5	Cell adhesion_Endothelial cell contacts by junctional mechanisms ²²	10.91	GJA1 GJA5
6	Antiarrhythmic Pathway, Pharmacodynamics ⁶¹	10.85	GJA1 GJA5 HCN2 HCN4 KCNJ3 SCN5A
7	TarBasePathway ¹	10.41	GJA1 HCN2 HCN4

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GO Terms for Sinoatrial Node Disease

Cellular components related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	gap junction	GO:0005921	9.33	GJA1 GJA5 GJC1
2	T-tubule	GO:0030315	9.32	KCNJ3 SCN5A
3	HCN channel complex	GO:0098855	9.26	HCN2 HCN4
4	connexin complex	GO:0005922	9.13	GJA1 GJA5 GJC1
5	intercalated disc	GO:0014704	8.92	GJA1 GJA5 GJC1 SCN5A

Biological processes related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 47)

#	Name	GO ID	Score	Top Affiliating Genes
1	heart development	GO:0007507	9.93	GJA1 GJA5 GJC1 SHOX2
2	transmembrane transport	GO:0055085	9.93	GJA1 GJA5 GJC1 HCN2 HCN4 SCN5A
3	cell-cell signaling	GO:0007267	9.87	GJA1 GJC1 HCN2
4	regulation of ion transmembrane transport	GO:0034765	9.87	HCN2 HCN4 KCNJ3 SCN5A
5	in utero embryonic development	GO:0001701	9.86	GJA1 MYH6 TBX3
6	potassium ion transport	GO:0006813	9.85	GJA5 HCN2 HCN4 KCNJ3
7	skeletal system development	GO:0001501	9.84	GJA5 SHOX2 TBX3
8	sodium ion transport	GO:0006814	9.83	HCN2 HCN4 SCN5A
9	sodium ion transmembrane transport	GO:0035725	9.81	HCN2 HCN4 SCN5A
10	muscle contraction	GO:0006936	9.8	GJA1 GJC1 HCN4 MYH6
11	cell communication	GO:0007154	9.78	GJA1 GJA5 GJC1
12	potassium ion import across plasma membrane	GO:1990573	9.75	HCN2 HCN4 KCNJ3
13	regulation of heart rate	GO:0002027	9.73	HCN4 MYH6 SCN5A
14	cardiac muscle contraction	GO:0060048	9.7	MYH6 SCN5A
15	ventricular septum morphogenesis	GO:0060412	9.69	GJA5 TBX3
16	regulation of heart contraction	GO:0008016	9.69	GJA1 MYH6
17	embryonic forelimb morphogenesis	GO:0035115	9.69	SHOX2 TBX3
18	positive regulation of vasoconstriction	GO:0045907	9.68	GJA1 GJA5
19	positive regulation of blood vessel diameter	GO:0097755	9.68	GJA1 GJA5
20	decidualization	GO:0046697	9.68	CYP27B1 GJA1
21	regulation of bone mineralization	GO:0030500	9.67	CYP27B1 GJA1
22	regulation of cardiac muscle contraction	GO:0055117	9.67	GJA5 HCN4
23	ventricular cardiac muscle cell action potential	GO:0086005	9.66	GJA5 SCN5A
24	adult heart development	GO:0007512	9.65	GJA1 MYH6
25	sodium ion import across plasma membrane	GO:0098719	9.65	HCN2 HCN4
26	cell communication by electrical coupling involved in cardiac conduction	GO:0086064	9.65	GJA1 GJA5
27	regulation of ventricular cardiac muscle cell membrane repolarization	GO:0060307	9.65	GJA1 GJA5 SCN5A
28	cardiac conduction	GO:0061337	9.64	GJA1 GJA5
29	cellular response to cGMP	GO:0071321	9.63	HCN2 HCN4
30	endothelium development	GO:0003158	9.62	GJA1 GJA5
31	cell communication by electrical coupling	GO:0010644	9.62	GJA1 GJA5
32	membrane depolarization during SA node cell action potential	GO:0086046	9.61	HCN4 SCN5A
33	embryonic heart tube development	GO:0035050	9.61	GJA1 GJA5 TBX3
34	AV node cell to bundle of His cell communication	GO:0086067	9.6	GJA5 SCN5A
35	AV node cell to bundle of His cell communication by electrical coupling	GO:0086053	9.59	GJA5 GJC1
36	cell communication by chemical coupling	GO:0010643	9.58	GJA1 GJA5
37	membrane depolarization during cardiac muscle cell action potential	GO:0086012	9.58	HCN2 HCN4 SCN5A
38	atrial ventricular junction remodeling	GO:0003294	9.54	GJA1 GJA5
39	regulation of atrial cardiac muscle cell membrane depolarization	GO:0060371	9.54	GJA1 GJA5 SCN5A
40	positive regulation of cell communication by chemical coupling	GO:0010652	9.52	GJA1 GJA5
41	SA node cell to atrial cardiac muscle cell communication by electrical coupling	GO:0086021	9.51	GJA5 GJC1
42	atrial cardiac muscle cell action potential	GO:0086014	9.5	GJA1 GJC1 SCN5A
43	regulation of ventricular cardiac muscle cell membrane depolarization	GO:0060373	9.43	GJA1 GJA5 SCN5A
44	gap junction assembly	GO:0016264	9.33	GJA1 GJA5 GJC1
45	SA node cell action potential	GO:0086015	9.13	GJA5 HCN4 SCN5A
46	regulation of heart rate by cardiac conduction	GO:0086091	8.92	GJA5 HCN4 KCNJ3 SCN5A
47	ion transport	GO:0006811	10	HCN2 HCN4 KCNJ3 SCN5A

Molecular functions related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	ion channel activity	GO:0005216	9.67	GJC1 HCN2 HCN4 SCN5A
2	disordered domain specific binding	GO:0097718	9.51	GJA1 GJA5
3	cAMP binding	GO:0030552	9.49	HCN2 HCN4
4	intracellular cAMP-activated cation channel activity	GO:0005222	9.48	HCN2 HCN4
5	connexin binding	GO:0071253	9.46	GJA1 GJA5
6	voltage-gated ion channel activity	GO:0005244	9.46	HCN2 HCN4 KCNJ3 SCN5A
7	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling	GO:0086077	9.43	GJA5 GJC1
8	sodium channel activity	GO:0005272	9.43	HCN2 HCN4 SCN5A
9	gap junction channel activity involved in cardiac conduction electrical coupling	GO:0086075	9.4	GJA1 GJA5
10	gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling	GO:0086020	9.32	GJA5 GJC1
11	voltage-gated sodium channel activity	GO:0005248	9.13	HCN2 HCN4 SCN5A
12	gap junction channel activity	GO:0005243	8.8	GJA1 GJA5 GJC1

Sources

Sources for Sinoatrial Node Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia