MCID: SNT005
MIFTS: 47

Sinoatrial Node Disease

Categories: Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Sinoatrial Node Disease

MalaCards integrated aliases for Sinoatrial Node Disease:

Name: Sinoatrial Node Disease 12 15
Sinus Node Dysfunction 70
Sinuatrial Node 12
Sa Node 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050824
UMLS 70 C0428908

Summaries for Sinoatrial Node Disease

Disease Ontology : 12 A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.

MalaCards based summary : Sinoatrial Node Disease, also known as sinus node dysfunction, is related to cardiac arrhythmia, ankyrin-b-related and third-degree atrioventricular block. An important gene associated with Sinoatrial Node Disease is HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4), and among its related pathways/superpathways are G-Beta Gamma Signaling and Myometrial Relaxation and Contraction Pathways. The drugs Digoxin and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 73 The sinoatrial node (also known as the sinuatrial node, SA node or sinus node) is a group of cells... more...

Related Diseases for Sinoatrial Node Disease

Diseases related to Sinoatrial Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 cardiac arrhythmia, ankyrin-b-related 31.6 SCN5A RYR2 KCNQ1 KCNH2 CACNA1C ANK2
2 third-degree atrioventricular block 31.5 TBX18 SCN5A SCN1B KCNH2 HCN4 GJA5
3 syncope 30.3 SCN5A RYR2 KCNQ1 KCNH2
4 sick sinus syndrome 29.6 TBX3 SCN5A SCN3B SCN1B MYH6 HCN4
5 atrioventricular block 29.3 SCN5A RYR2 NKX2-5 KCNQ1 KCNH2 HCN4
6 cardiac arrhythmia 29.1 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
7 atrial fibrillation 29.1 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
8 chronic atrial and intestinal dysrhythmia 11.4
9 multifocal atrial tachycardia 11.3
10 atrial standstill 10.4 SCN5A GJA5
11 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.3
12 hallermann-streiff syndrome 10.3 GJC1 GJA1
13 anomalous left coronary artery from the pulmonary artery 10.3 TBX18 GJA1
14 left ventricular noncompaction 1 10.3 SCN5A MYH6
15 idiopathic ventricular fibrillation, non brugada type 10.3 SCN5A RYR2 CACNA1C
16 familial sick sinus syndrome 10.3 SCN5A MYH6 HCN4
17 familial periodic paralysis 10.3 SCN5A CACNA1D CACNA1C
18 progressive familial heart block, type ia 10.3 SCN5A GJA5 ANK2
19 clouston syndrome 10.3 GJC1 GJA5 GJA1
20 lateral myocardial infarction 10.3 SCN5A SCN1B
21 hypokalemic periodic paralysis, type 1 10.2 SCN5A CACNA1D CACNA1C
22 hereditary lymphedema ic 10.2 SCN5A GJC1 GJA5 GJA1
23 brugada syndrome 3 10.2 CACNA1C ANK2
24 testicular thecoma 10.2 GJD3 GJC3
25 first-degree atrioventricular block 10.2 SCN5A KCNH2
26 brugada syndrome 1 10.2 SCN5A RYR2 KCNH2
27 myasthenic syndrome, congenital, 20, presynaptic 10.2 NKX2-5 MYH6
28 isolated elevated serum creatine phosphokinase levels 10.2 SCN5A RYR2 HCN4 CACNA1C
29 long qt syndrome 15 10.2 SCN1B CACNA1C
30 anhidrosis, isolated, with normal sweat glands 10.2 RYR2 CACNA1C
31 bart-pumphrey syndrome 10.2 GJC3 GJC1 GJA1
32 second-degree atrioventricular block 10.2 SCN5A SCN3B HCN4 CACNA1D
33 ulnar-mammary syndrome 10.2 TBX3 TBX18 NKX2-5 GJA5
34 long qt syndrome 10 10.2 SCN5A KCNQ1 ANK2
35 fanconi renotubular syndrome 1 10.2 NKX2-5 GJA1
36 paroxysmal extreme pain disorder 10.1 SCN5A SCN3B SCN1B
37 erythrokeratodermia variabilis et progressiva 1 10.1 GJC3 GJC1 GJA1
38 familial short qt syndrome 10.1 KCNQ1 KCNH2
39 long qt syndrome 11 10.1 KCNQ1 CACNA1C ANK2
40 neuromuscular junction disease 10.1 SCN5A RYR2 KCNH2 CACNA1C
41 developmental and epileptic encephalopathy 14 10.1 SCN5A KCNQ1 KCNH2
42 oculodentodigital dysplasia 10.1 GJC3 GJC1 GJA5 GJA1
43 right atrial isomerism 10.1 SHOX2 NKX2-5 GJA5
44 patent foramen ovale 10.1 TBX3 NKX2-5 MYH6 GJA5
45 leukodystrophy, hypomyelinating, 2 10.1 GJD3 GJC3 GJC1 GJA1
46 hypoplastic left heart syndrome 10.1 NKX2-5 MYH6 GJA5 GJA1
47 ebstein anomaly 10.1 SCN5A NKX2-5 MYH6 HCN4 GJA5
48 hypokalemia 10.1 KCNQ1 KCNH2 CACNA1D
49 long qt syndrome 14 10.1 SCN5A KCNQ1 KCNH2 CACNA1C
50 polykaryocytosis inducer 10.0

Comorbidity relations with Sinoatrial Node Disease via Phenotypic Disease Network (PDN): (show all 48)


Acute Cystitis Acute Kidney Failure
Anxiety Aortic Valve Disease 1
Atrioventricular Block Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Disease Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hypertension, Essential
Hypertrophic Cardiomyopathy Hypoglycemia
Hypothyroidism Idiopathic Peripheral Autonomic Neuropathy
Intermediate Coronary Syndrome Intracranial Embolism
Kidney Disease Left Bundle Branch Hemiblock
Malignant Essential Hypertension Mitral Valve Disease
Mitral Valve Stenosis Mobitz Type Ii Atrioventricular Block
Monocular Esotropia Nutmeg Liver
Peripheral Vascular Disease Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Rheumatic Heart Disease Right Bundle Branch Block
Schizophreniform Disorder Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Tricuspid Valve Disease
Ventricular Fibrillation, Paroxysmal Familial, 1 Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Sinoatrial Node Disease:



Diseases related to Sinoatrial Node Disease

Symptoms & Phenotypes for Sinoatrial Node Disease

MGI Mouse Phenotypes related to Sinoatrial Node Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 CACNA1C CACNA1D GJA1 GJA5 GJC1 GJC3
2 growth/size/body region MP:0005378 10.31 CACNA1C CACNA1D GJA1 GJC1 GJC3 KCNH2
3 mortality/aging MP:0010768 10.22 CACNA1C CACNA1D GJA1 GJA5 GJC1 GJD3
4 homeostasis/metabolism MP:0005376 10.21 CACNA1C CACNA1D GJA1 GJA5 GJC1 KCNH2
5 embryo MP:0005380 10.13 CACNA1C GJA1 GJC1 KCNH2 NKX2-5 RYR2
6 muscle MP:0005369 10.1 CACNA1C GJA1 GJA5 GJC1 HCN4 KCNH2
7 craniofacial MP:0005382 10 CACNA1C GJA1 KCNH2 NKX2-5 SHOX2 TBX18
8 nervous system MP:0003631 10 CACNA1C CACNA1D GJA1 GJC1 GJC3 GJD3
9 no phenotypic analysis MP:0003012 9.56 GJA1 GJA5 GJC1 GJD3 NKX2-5 RYR2
10 normal MP:0002873 9.28 GJA1 GJA5 HCN4 KCNQ1 NKX2-5 RYR2

Drugs & Therapeutics for Sinoatrial Node Disease

Drugs for Sinoatrial Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Digoxin Approved 20830-75-5 30322 2724385
2
Amiodarone Approved, Investigational 1951-25-3 2157
3
Propafenone Approved 54063-53-5 4932
4
Dronedarone Approved 141626-36-0, 141625-93-6 154087
5 Adrenergic beta-Antagonists
6 Anti-Arrhythmia Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Prevention of Atrial Arrhythmia in Patients Without AV Conduction Disease Completed NCT01170611 Phase 4
2 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
3 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
4 INGEVITY(TM) Active Fixation and Passive Fixation Pace/ Sense Lead Clinical Study Completed NCT01688843
5 Effectiveness of Closed Loop Stimulation (CLS) With His Bundle Lead Placement Completed NCT03601754
6 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Completed NCT01643707
7 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction. Completed NCT02027909
8 Right Ventricular Outflow Tract Septal Pacing for Cardiac Dysfunction Prevention Evaluation Completed NCT01294839
9 Evolution of the PR Interval in Patients Implanted With a Dual Chamber Pacemaker With Algorithm for Spontaneous AV Conduction Preservation Completed NCT02586480
10 Cleveland Clinic Arrhythmia Biospecimen Repository (Cleveland Clinic Arrhythmia BioBank) Recruiting NCT00921986
11 BIO|REDUCE: Cardiac REsynchronization Therapy With Two Ventricular Leads and Right Atrial Floating Diagnostic Dipole Installed in the Right ventricUlar Lead in Patients With CRT-D indiCation and no Sinus nodE Dysfunction Recruiting NCT03839121
12 Stepwise Atrial Fibrillation supprEssion Treatment in Patients With Paroxysmal Atrial Fibrillation and Sinus Node Dysfunction: Intensive Device Follow-up Active, not recruiting NCT03607123 Anti arryhthmic drugs
13 Fluoroless Permanent HIS Bundle Pacing Utilizing Electro-anatomic Mapping Versus Conventional Implantation Enrolling by invitation NCT03903107
14 Effect of Long-term Atrial Pacing on Central Blood Pressure in Permanently Paced Sick Sinus Syndrome Patients With Primary Arterial Hypertension Not yet recruiting NCT04309175

Search NIH Clinical Center for Sinoatrial Node Disease

Genetic Tests for Sinoatrial Node Disease

Anatomical Context for Sinoatrial Node Disease

MalaCards organs/tissues related to Sinoatrial Node Disease:

40
Heart, Atrioventricular Node, Endothelial, Brain

Publications for Sinoatrial Node Disease

Articles related to Sinoatrial Node Disease:

(show top 50) (show all 1503)
# Title Authors PMID Year
1
Management of Arrhythmias After Heart Transplant: Current State and Considerations for Future Research. 61
33685207 2021
2
COVID-19-associated multisystem inflammatory syndrome in children presenting uniquely with sinus node dysfunction in the setting of shock. 61
33745461 2021
3
Clinical course of sinus node dysfunction after thoracoscopic surgery for atrial fibrillation-analysis of the Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery (AFACT) study. 61
32172425 2021
4
The multisystem nature of isomerism: left isomerism complicated by Abernethy malformation and portopulmonary hypertension. 61
33731242 2021
5
Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease. 61
33739154 2021
6
Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. 61
33706013 2021
7
Post-operative arrhythmias in patients with hypoplastic left heart syndrome and anatomic variants: incidence, type, and course. 61
33685535 2021
8
Permanent pacemaker implantation in unexplained syncope patients with borderline sinus bradycardia and electrophysiology study-proven sinus node disease. 61
33664902 2021
9
Relapsing polychondritis associated with heart block. 61
33660817 2021
10
Left ventricular stiffness assessed by diastolic Wall strain predicts asymptomatic atrial high-rate episodes in patients with pacemaker implantation. 61
32888831 2021
11
The mid-term outcome of Fontan conversion compared with primary total cavopulmonary connection. 61
33648806 2021
12
Screening for ATTR amyloidosis in the clinic: overlapping disorders, misdiagnosis, and multiorgan awareness. 61
33609196 2021
13
Sinus node disfunction in an adolescent with systemic lupus erythematosus. 61
33215560 2021
14
Multiple arrhythmic and cardiomyopathic phenotypes associated with an SCN5A A735E mutation. 61
33610078 2021
15
A comparison of AAIR versus DDDR pacing for patients with sinus node dysfunction: a long-term follow-up study. 61
32946543 2021
16
Evaluation of different lead types and implantation techniques in pediatric populations with permanent pacemakers: Single-center with 10 years' experience. 61
33179296 2021
17
Feasibility, safety and outcomes of left bundle branch pacing in octogenarians. 61
33714396 2021
18
Evaluation and Management of Asymptomatic Bradyarrhythmias. 61
32693770 2021
19
Syncope Associated with Sinus Nodal Dysfunction in a COVID-19 Patient: A Case Report and Review of the Literature. 61
33665366 2021
20
Mid- to long-term surgical outcomes of partial anomalous pulmonary venous connection. 61
32686032 2021
21
VVI pacing with normal QRS duration and ventricular function: MOST trial findings relevant to leadless pacemakers. 61
33085123 2020
22
Shortness of breath and palpitations in an elderly man: Bad device behavior or malfunction? 61
33335635 2020
23
Retrieval of a leadless transcatheter pacemaker from the right pulmonary artery: A case report. 61
33283282 2020
24
MOST but only almost: Are leadless pacemakers appropriate in sinus node dysfunction? 61
33085110 2020
25
Initial Experience, Safety, and Feasibility of Left Bundle Branch Area Pacing: A Multicenter Prospective Study. 61
33357573 2020
26
Subcutaneous implantable cardioverter-defibrillator was inappropriate for use in a patient with aborted sudden cardiac death due to coronary spastic angina: a case report. 61
33442640 2020
27
Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking. 61
33095298 2020
28
Dizziness during atrial antitachycardia pacing: What is the cause. 61
32864770 2020
29
Jaw Pain and Profound Bradycardia - An Atypical Presentation of Lyme Carditis. 61
33364125 2020
30
[Modified Warden Procedure for Correction of Partial Anomalous Pulmonary Venous Connection and Sinus Venosus Atrial Septal Defect in an Adult]. 61
33268745 2020
31
Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series. 61
33089039 2020
32
Sinoatrial nodal artery injury in thoracoscopic epicardial ablation for atrial fibrillation. 61
33111149 2020
33
Persistent Left Superior Vena Cava with Absent Right Superior Vena Cava and Discrete Subaortic Stenosis Diagnosed in a Patient with Sick Sinus Syndrome: A Case Report and Brief Review of the Literature. 61
33086768 2020
34
The Warden procedure for partial anomalous pulmonary venous connection in children: 10 years experience in 65 cases. 61
32811584 2020
35
Novel Behavior of the 2019 Novel Coronavirus With Invasion of the Cardiac Conduction System in the Young. 61
33240711 2020
36
[Intellectual developmental disorder with cardiac arrhythmia syndrome in a family caused by GNB5 variation and literature review]. 61
32987464 2020
37
Clinical profile and outcome of familial versus non-familial atrial fibrillation. 61
32273045 2020
38
Atrioventricular and Sinus Node Dysfunction in Stable COVID-19 Patients. 61
32901230 2020
39
Bradyarrhythmias in patients with COVID-19: A case series. 61
32822746 2020
40
Salvage of an epicardial lead in a pacemaker-dependent patient with Fontan palliation using an IS-1 extender. 61
32716084 2020
41
Increasing atrial fibrillation: What is the cause? 61
32602237 2020
42
Cardiac Implantable Electronic Devices Following Heart Transplantation. 61
32819520 2020
43
Implantable cardiac electronic device therapy for patients with a systemic right ventricle. 61
32269130 2020
44
Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity. 61
32601767 2020
45
Cardiac and neuronal HCN channelopathies. 61
32424620 2020
46
Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia. 61
32115705 2020
47
Azygos Vein to the Rescue of Warden Anastomosis in High Pulmonary Venous Drainage. 61
30336739 2020
48
Identification of Functional Variant Enhancers Associated With Atrial Fibrillation. 61
32248749 2020
49
Comparison of safety and outcomes with two approaches to the mitral valve. 61
32365427 2020
50
Sinus Node Dysfunction in a Young Patient With COVID-19. 61
32835265 2020

Variations for Sinoatrial Node Disease

Expression for Sinoatrial Node Disease

Search GEO for disease gene expression data for Sinoatrial Node Disease.

Pathways for Sinoatrial Node Disease

Pathways related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 SCN5A SCN3B SCN1B GJC1 GJA5 GJA1
2
Show member pathways
12.4 RYR2 GJC1 GJA5 GJA1 CACNA1D CACNA1C
3
Show member pathways
12.38 SCN5A SCN3B SCN1B RYR2 NKX2-5 MYH6
4
Show member pathways
12.37 SCN5A SCN1B RYR2 MYH6 KCNQ1 CACNA1D
5 12.24 KCNQ1 KCNH2 CACNA1D CACNA1C
6 12.21 RYR2 HCN4 CACNA1D CACNA1C
7
Show member pathways
12.13 RYR2 MYH6 CACNA1D CACNA1C
8 12.01 RYR2 GJA1 CACNA1D CACNA1C
9 11.94 SCN5A SCN3B RYR2 KCNQ1 KCNH2 GJA1
10
Show member pathways
11.91 SCN5A SCN3B SCN1B ANK2
11
Show member pathways
11.79 GJD3 GJC1 GJA5 GJA1
12 11.72 RYR2 MYH6 CACNA1D CACNA1C
13 11.51 KCNQ1 CACNA1D CACNA1C
14
Show member pathways
11.51 SCN5A SCN3B SCN1B KCNQ1 CACNA1D CACNA1C
15 11.45 SCN5A NKX2-5 MYH6
16 11.4 RYR2 CACNA1D CACNA1C
17 11.18 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
18 11.15 SCN5A SCN3B SCN1B ANK2
19 10.91 KCNQ1 HCN4 GJA1
20 10.88 CACNA1D CACNA1C
21 10.67 CACNA1D CACNA1C

GO Terms for Sinoatrial Node Disease

Cellular components related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.32 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
2 plasma membrane GO:0005886 10.24 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
3 cell junction GO:0030054 10 GJD3 GJC3 GJC1 GJA5 GJA1 CACNA1C
4 sarcolemma GO:0042383 9.73 SCN5A RYR2 CACNA1C ANK2
5 gap junction GO:0005921 9.65 GJD3 GJC3 GJC1 GJA5 GJA1
6 T-tubule GO:0030315 9.62 SCN5A SCN1B CACNA1C ANK2
7 voltage-gated sodium channel complex GO:0001518 9.58 SCN5A SCN3B SCN1B
8 connexin complex GO:0005922 9.55 GJD3 GJC3 GJC1 GJA5 GJA1
9 Z disc GO:0030018 9.5 SCN5A SCN3B RYR2 MYH6 CACNA1D CACNA1C
10 L-type voltage-gated calcium channel complex GO:1990454 9.49 CACNA1D CACNA1C
11 intercalated disc GO:0014704 9.1 SCN5A SCN1B GJC1 GJA5 GJA1 ANK2

Biological processes related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.25 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
2 transmembrane transport GO:0055085 10.15 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJD3
3 heart development GO:0007507 10.11 SHOX2 NKX2-5 GJC1 GJA5 GJA1 CACNA1C
4 ion transmembrane transport GO:0034220 10.11 SCN5A SCN3B SCN1B RYR2 KCNH2 GJD3
5 cell-cell signaling GO:0007267 10.05 GJD3 GJC3 GJC1 GJA5 GJA1
6 regulation of ion transmembrane transport GO:0034765 10.03 SCN5A SCN3B SCN1B KCNQ1 KCNH2 HCN4
7 potassium ion transport GO:0006813 9.99 KCNQ1 KCNH2 HCN4 GJA5
8 cell communication GO:0007154 9.99 GJD3 GJC3 GJC1 GJA5 GJA1
9 sodium ion transport GO:0006814 9.98 SCN5A SCN3B SCN1B HCN4
10 sodium ion transmembrane transport GO:0035725 9.97 SCN5A SCN3B SCN1B HCN4
11 regulation of heart rate GO:0002027 9.97 SCN5A RYR2 MYH6 HCN4 ANK2
12 regulation of cardiac muscle contraction GO:0055117 9.96 RYR2 NKX2-5 HCN4 GJA5 ANK2
13 cardiac conduction GO:0061337 9.95 SCN5A SCN3B SCN1B KCNQ1 KCNH2 CACNA1D
14 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.92 SCN5A SCN1B KCNQ1 KCNH2 ANK2
15 muscle contraction GO:0006936 9.91 MYH6 HCN4 GJC1
16 positive regulation of sodium ion transport GO:0010765 9.91 SCN5A SCN3B SCN1B NKX2-5
17 cardiac muscle cell action potential involved in contraction GO:0086002 9.89 SCN5A SCN3B SCN1B CACNA1D CACNA1C
18 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.88 SCN5A SCN3B SCN1B GJA5
19 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.88 RYR2 GJD3 GJA5 GJA1 CACNA1C
20 gap junction assembly GO:0016264 9.87 GJD3 GJC1 GJA5 GJA1
21 embryonic forelimb morphogenesis GO:0035115 9.85 TBX3 SHOX2 CACNA1C
22 membrane depolarization during SA node cell action potential GO:0086046 9.85 SCN5A HCN4 CACNA1D ANK2
23 SA node cell action potential GO:0086015 9.84 SCN5A SCN3B HCN4 ANK2
24 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.83 RYR2 CACNA1C ANK2
25 positive regulation of heart rate GO:0010460 9.82 SCN3B RYR2 KCNQ1
26 membrane depolarization GO:0051899 9.82 SCN5A SCN3B SCN1B
27 membrane depolarization during action potential GO:0086010 9.81 SCN5A SCN3B KCNH2
28 AV node cell to bundle of His cell communication by electrical coupling GO:0086053 9.81 GJD3 GJC3 GJC1 GJA5
29 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.8 SCN5A KCNQ1 CACNA1D
30 sinoatrial node cell development GO:0060931 9.8 TBX3 TBX18 SHOX2
31 ventricular cardiac muscle cell action potential GO:0086005 9.8 SCN5A SCN3B RYR2 KCNQ1 KCNH2 ANK2
32 regulation of atrial cardiac muscle cell action potential GO:0098910 9.79 RYR2 GJA5 ANK2
33 regulation of SA node cell action potential GO:0098907 9.79 TBX18 RYR2 ANK2
34 regulation of sodium ion transmembrane transporter activity GO:2000649 9.74 SCN3B SCN1B
35 positive regulation of blood vessel diameter GO:0097755 9.74 GJA5 GJA1
36 regulation of potassium ion transmembrane transport GO:1901379 9.74 KCNH2 CACNA1D
37 smooth muscle cell differentiation GO:0051145 9.74 TBX3 TBX18
38 embryonic heart tube development GO:0035050 9.74 TBX3 NKX2-5
39 potassium ion export across plasma membrane GO:0097623 9.73 KCNQ1 KCNH2
40 positive regulation of potassium ion transmembrane transport GO:1901381 9.73 KCNQ1 KCNH2
41 calcium ion transport into cytosol GO:0060402 9.73 RYR2 CACNA1C
42 regulation of cardiac muscle cell contraction GO:0086004 9.73 SCN5A ANK2
43 cellular response to epinephrine stimulus GO:0071872 9.73 RYR2 KCNQ1
44 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.73 SCN5A SCN3B SCN1B HCN4 CACNA1D CACNA1C
45 adult heart development GO:0007512 9.72 NKX2-5 MYH6
46 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.72 KCNQ1 KCNH2
47 positive regulation of stem cell proliferation GO:2000648 9.72 TBX3 GJA1
48 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.72 RYR2 CACNA1C
49 membrane repolarization GO:0086009 9.72 KCNQ1 KCNH2
50 regulation of membrane repolarization GO:0060306 9.71 KCNQ1 KCNH2

Molecular functions related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.59 TBX3 TBX18 SHOX2 SCN5A SCN3B SCN1B
2 calmodulin binding GO:0005516 9.85 SCN5A RYR2 MYH6 KCNQ1 CACNA1C
3 calcium channel activity GO:0005262 9.8 RYR2 CACNA1D CACNA1C
4 ion channel binding GO:0044325 9.8 SCN5A SCN3B SCN1B RYR2 KCNQ1 ANK2
5 potassium channel activity GO:0005267 9.77 KCNQ1 KCNH2 HCN4
6 voltage-gated potassium channel activity GO:0005249 9.75 KCNQ1 KCNH2 HCN4
7 scaffold protein binding GO:0097110 9.73 SCN5A KCNQ1 KCNH2
8 sodium channel activity GO:0005272 9.73 SCN5A SCN3B SCN1B HCN4
9 voltage-gated sodium channel activity GO:0005248 9.65 SCN5A SCN1B HCN4
10 gap junction channel activity GO:0005243 9.65 GJD3 GJC3 GJC1 GJA5 GJA1
11 alpha-actinin binding GO:0051393 9.63 CACNA1D CACNA1C
12 protein kinase A catalytic subunit binding GO:0034236 9.62 RYR2 KCNQ1
13 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.61 KCNQ1 KCNH2
14 high voltage-gated calcium channel activity GO:0008331 9.59 CACNA1D CACNA1C
15 sodium channel inhibitor activity GO:0019871 9.58 SCN3B SCN1B
16 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.58 SCN5A SCN3B SCN1B
17 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.57 KCNQ1 KCNH2
18 voltage-gated ion channel activity GO:0005244 9.56 SCN5A SCN3B SCN1B KCNQ1 KCNH2 HCN4
19 connexin binding GO:0071253 9.55 GJA5 GJA1
20 gap junction hemi-channel activity GO:0055077 9.54 GJA5 GJA1
21 gap junction channel activity involved in cardiac conduction electrical coupling GO:0086075 9.54 GJD3 GJA5 GJA1
22 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.52 CACNA1D CACNA1C
23 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.51 SCN5A SCN1B
24 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling GO:0086020 9.49 GJC1 GJA5
25 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GO:0086077 9.46 GJD3 GJC3 GJC1 GJA5
26 ion channel activity GO:0005216 9.28 SCN5A RYR2 KCNQ1 KCNH2 HCN4 GJD3

Sources for Sinoatrial Node Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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