MCID: SNT005
MIFTS: 44

Sinoatrial Node Disease

Categories: Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Sinoatrial Node Disease

MalaCards integrated aliases for Sinoatrial Node Disease:

Name: Sinoatrial Node Disease 12 15
Sinus Node Dysfunction 73
Sinuatrial Node 12
Sa Node 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050824
UMLS 73 C0428908

Summaries for Sinoatrial Node Disease

Disease Ontology : 12 A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.

MalaCards based summary : Sinoatrial Node Disease, also known as sinus node dysfunction, is related to sick sinus syndrome and third-degree atrioventricular block. An important gene associated with Sinoatrial Node Disease is SHOX2 (Short Stature Homeobox 2), and among its related pathways/superpathways are G-Beta Gamma Signaling and Myometrial Relaxation and Contraction Pathways. The drugs Propafenone and Sotalol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 The sinoatrial node (SA node), also known as sinus node, is a group of cells located in the wall of the... more...

Related Diseases for Sinoatrial Node Disease

Diseases related to Sinoatrial Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 sick sinus syndrome 32.2 HCN4 MYH6 SCN5A SHOX2
2 third-degree atrioventricular block 32.0 HCN4 SCN5A
3 multifocal atrial tachycardia 11.3
4 atrioventricular block 11.2
5 long qt syndrome 9 10.1 HCN4 SCN5A
6 atrial standstill 10.1 GJA5 SCN5A
7 progressive familial heart block 10.1 GJA5 SCN5A
8 progressive familial heart block, type ia 10.1 GJA5 SCN5A
9 right bundle branch block 10.1 HCN4 SCN5A
10 ulnar-mammary syndrome 10.0 TBX18 TBX3
11 familial sick sinus syndrome 10.0 HCN4 MYH6 SCN5A
12 first-degree atrioventricular block 10.0 GJA5 GJC1 SCN5A
13 holt-oram syndrome 10.0 MYH6 SHOX2 TBX3
14 lymphoma 10.0
15 syncope 10.0
16 left ventricular noncompaction 10.0 HCN4 MYH6 SCN5A
17 atrial standstill 1 10.0 GJA5 MYH6 SCN5A
18 axenfeld-rieger syndrome 10.0 GJA1 SHOX2
19 oculodentodigital dysplasia 9.9 GJA1 GJA5 GJC1
20 arrhythmogenic right ventricular cardiomyopathy 9.9 GJA1 HCN4 SCN5A
21 familial isolated dilated cardiomyopathy 9.9 MYH6 SCN5A
22 achondroplasia 9.9
23 heart conduction disease 9.8 GJA1 GJA5 HCN4 SCN5A SHOX2
24 atrial fibrillation 9.7 GJA1 GJA5 HCN4 SCN5A SHOX2
25 heart disease 9.7 GJA1 GJA5 HCN4 MYH6 SCN5A
26 dilated cardiomyopathy 9.7 GJA1 GJA5 MYH6 SCN5A

Comorbidity relations with Sinoatrial Node Disease via Phenotypic Disease Network (PDN): (show all 50)


Acute Cystitis Acute Kidney Failure
Anxiety Aortic Valve Disease 1
Atrioventricular Block Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hypertension, Essential Hypertrophic Cardiomyopathy
Hypoglycemia Hypothyroidism
Idiopathic Peripheral Autonomic Neuropathy Intermediate Coronary Syndrome
Intracranial Embolism Ischemic Heart Disease
Kidney Disease Left Bundle Branch Hemiblock
Malignant Essential Hypertension Mitral Valve Disease
Mitral Valve Stenosis Mobitz Type Ii Atrioventricular Block
Monocular Esotropia Nutmeg Liver
Peripheral Vascular Disease Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Rheumatic Heart Disease Right Bundle Branch Block
Schizophreniform Disorder Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Tricuspid Valve Disease
Ventricular Fibrillation, Paroxysmal Familial, 1 Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Sinoatrial Node Disease:



Diseases related to Sinoatrial Node Disease

Symptoms & Phenotypes for Sinoatrial Node Disease

MGI Mouse Phenotypes related to Sinoatrial Node Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 CYP27B1 GJA1 GJA5 GJC1 HCN2 HCN4
2 growth/size/body region MP:0005378 9.76 CYP27B1 GJA1 GJC1 HCN2 SCN5A SHOX2
3 craniofacial MP:0005382 9.65 CYP27B1 GJA1 SHOX2 TBX18 TBX3
4 mortality/aging MP:0010768 9.65 GJA1 GJA5 GJC1 HCN2 HCN4 MYH6
5 muscle MP:0005369 9.28 CYP27B1 GJA1 GJA5 GJC1 HCN4 MYH6

Drugs & Therapeutics for Sinoatrial Node Disease

Drugs for Sinoatrial Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propafenone Approved Phase 4 54063-53-5 4932
2
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
3
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
4
Atenolol Approved Phase 4 29122-68-7 2249
5
Nebivolol Approved, Investigational Phase 4 99200-09-6, 152520-56-4, 118457-14-0 71301
6
Ethanol Approved Phase 4 64-17-5 702
7
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
8 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
10 Sodium Channel Blockers Phase 4
11 Adrenergic Agents Phase 4
12 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
13 Diuretics, Potassium Sparing Phase 4
14 Autonomic Agents Phase 4
15 Anti-Arrhythmia Agents Phase 4,Not Applicable
16 Adrenergic beta-Antagonists Phase 4
17 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Potassium Channel Blockers Phase 4
20 Neurotransmitter Agents Phase 4
21 Cytochrome P-450 CYP3A Inhibitors Phase 4
22 Vasodilator Agents Phase 4
23 Sympatholytics Phase 4
24 Adrenergic Antagonists Phase 4
25 Antihypertensive Agents Phase 4,Not Applicable
26 Adrenergic beta-Agonists Phase 4
27 Adrenergic beta-1 Receptor Antagonists Phase 4
28 Adrenergic Agonists Phase 4
29
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
30
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
31
Ofloxacin Approved Phase 3 82419-36-1 4583
32
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 10909430 439542
33
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
34 Topoisomerase Inhibitors Phase 3
35 Polymyxins Phase 3
36 Anti-Bacterial Agents Phase 3
37 Anti-Infective Agents, Local Phase 3
38 Renal Agents Phase 3
39 Anti-Infective Agents Phase 3
40 Clindamycin palmitate Phase 3
41 Clindamycin phosphate Phase 3
42 Polymyxin B Phase 3
43 Antibiotics, Antitubercular Phase 3
44 Anti-Infective Agents, Urinary Phase 3
45 Antitubercular Agents Phase 3
46
Angiotensin II Approved, Investigational ,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
47
Losartan Approved Not Applicable 114798-26-4 3961
48 tannic acid Approved Not Applicable
49
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
50
Digoxin Approved 20830-75-5 30322 2724385

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
2 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
3 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
4 Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation Unknown status NCT02145546 Phase 4 Amiodarone;Propafenone;Sotalol
5 Syncope: Pacing or Recording in the Later Years Unknown status NCT01423994 Phase 4
6 The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker Completed NCT03245996 Phase 4 Atenolol Pill;Nebivolol Pill;Ivabradine Pill
7 Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation Completed NCT00161538 Phase 4
8 Austria Study - Analysis of Difference Between Active and Passive Fixation Leads Completed NCT00180557 Phase 4
9 Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease Completed NCT01170611 Phase 4
10 Falls and Cardiovascular Events in Pacemaker Patients Completed NCT01037426 Phase 4
11 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
12 Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease Recruiting NCT03566667 Phase 4 Metoprolol;Standard care
13 Virtual Clinic Pacemaker Follow-up Terminated NCT00475124 Phase 4
14 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation Completed NCT02317068 Phase 3
15 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
16 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
17 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
18 Second Study on Cardio-neuromodulation in Humans Unknown status NCT02954666 Phase 2
19 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
20 The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome Unknown status NCT01310920
21 The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome Unknown status NCT00647257 Not Applicable Losartan;Placebo
22 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241 Not Applicable
23 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
24 Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position Unknown status NCT01647490 Not Applicable
25 Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance Unknown status NCT01798043 Not Applicable
26 Minimizing Ventricular Pacing Unknown status NCT01611389 Not Applicable
27 Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study Completed NCT01528657 Not Applicable
28 Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI) Completed NCT00785564
29 Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot Completed NCT02198781
30 Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858
31 The Atrial High Rate Episodes in Pacemaker Patients Completed NCT00627328
32 Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class Completed NCT00292539
33 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum Completed NCT01609738
34 SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction Completed NCT00284830 Not Applicable
35 Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) Completed NCT00664807
36 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed NCT00478933 Not Applicable
37 Brady MX a Quality Improvement Study Completed NCT02976181
38 To Pace or Not to Pace in Sinus Node Disease Completed NCT02485093 Not Applicable
39 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction Completed NCT02027909
40 Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing Completed NCT01803217 Not Applicable
41 Right Ventricular Outflow Tract Study Completed NCT01294839 Not Applicable
42 Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PATCH-ED) Completed NCT02683174 Not Applicable
43 Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode Completed NCT02586480
44 Ingenio Device Algorithm Study Completed NCT01441583 Not Applicable
45 IES-ACap: Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm. Completed NCT00832260
46 PANORAMA Observational Study Completed NCT00382525
47 Real Life Automatic Atrial Capture Device Control Completed NCT02400983
48 Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome. Recruiting NCT02034526 Not Applicable
49 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Recruiting NCT02314897 Not Applicable
50 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717 Not Applicable

Search NIH Clinical Center for Sinoatrial Node Disease

Genetic Tests for Sinoatrial Node Disease

Anatomical Context for Sinoatrial Node Disease

MalaCards organs/tissues related to Sinoatrial Node Disease:

41
Heart, Testes, Atrioventricular Node

Publications for Sinoatrial Node Disease

Articles related to Sinoatrial Node Disease:

(show top 50) (show all 301)
# Title Authors Year
1
Sinoatrial Node Disease in Adults with Down's Syndrome. ( 29588556 )
2018
2
Sinus node dysfunction after surgical atrial fibrillation ablation with concomitant mitral valve surgery: Determinants and clinical outcomes. ( 30208099 )
2018
3
Interleukin-10 Treatment Attenuates Sinus Node Dysfunction Caused by Streptozotocin-induced Hyperglycemia in Mice. ( 29982291 )
2018
4
Unifocal Right-Sided Ablation Treatment for Neurally Mediated Syncope and Functional Sinus Node Dysfunction Under Computed Tomographic Guidance. ( 30354289 )
2018
5
Sinus node dysfunction after heart transplantation-An analysis of risk factors and atrial pacing burden. ( 29345729 )
2018
6
Catheter ablation of the slow pathway as a treatment for severe sinus node dysfunction in a patient with incessant atrioventricular nodal reentry tachycardia. ( 29707487 )
2018
7
A case of atenolol-induced sinus node dysfunction presenting as escape-capture bigeminy. ( 29868180 )
2018
8
Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement. ( 30275471 )
2018
9
Prevalence and predictors of atrial arrhythmias in patients with sinus node dysfunction and atrial pacing. ( 30293095 )
2018
10
Guillain-Barré Syndrome Presenting with Sinus Node Dysfunction and Refractory Shock. ( 28283677 )
2017
11
Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction. ( 27702858 )
2017
12
Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon? ( 28155995 )
2017
13
Pacing Discovery: G-Protein β Subunit Mutations in Sinus Node Dysfunction. ( 28495981 )
2017
14
Under-utilization of pacemaker therapy for sinus node dysfunction - Real world data from South Asia. ( 29054184 )
2017
15
Rapidly progressive cardiac sarcoidosis: Initial presentation with sinus node dysfunction and right bundle branch block. ( 28491632 )
2016
16
Simplified Cardioneuroablation in the Treatment of Reflex Syncope, Functional AV Block, and Sinus Node Dysfunction. ( 26411271 )
2016
17
Cardiac pacing strategies and post-implantation risk of atrial fibrillation and heart failure events in sinus node dysfunction patients: a collaborative analysis of over 6000 patients. ( 26913516 )
2016
18
Sinus Node Dysfunction After Extracardiac Conduit and Lateral Tunnel Fontan Operation: The Importance of the Type of Prior Superior Cavopulmonary Anastomosis. ( 26957405 )
2016
19
Acute Sinus Node Dysfunction after Atrial Ablation: Incidence, Risk Factors, and Management. ( 27530090 )
2016
20
Sinus Node Dysfunction: A Rare Side Effect of Tigecyclin. ( 27766826 )
2016
21
Transvenous approach to pacemaker lead implantation for sinus node dysfunction after extracardiac lateral tunnel Fontan conduit placement. ( 28491745 )
2016
22
Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction. ( 26282245 )
2016
23
Transient sinus node dysfunction following sinus node artery occlusion due to radiofrequency catheter ablation of the septal superior vena cava-right atrium junction. ( 26607406 )
2016
24
Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry. ( 26720750 )
2016
25
Warning leak of intracranial aneurysm masquerading as sinus node dysfunction: A case report. ( 27489696 )
2015
26
Sinus Node Dysfunction After Acute Lithium Treatment at Therapeutic Levels. ( 27222761 )
2015
27
Sinus node dysfunction complicating viper bite. ( 24887872 )
2015
28
Ankyrin-B syndrome: a case of sinus node dysfunction, atrial fibrillation and prolonged QT in a young adult. ( 25456501 )
2015
29
Sinus node dysfunction requiring permanent pacemaker implantation in a young adult with Klinefelter syndrome. ( 25744562 )
2015
30
Side effects of ticagrelor: Sinus node dysfunction with ventricular pause. ( 25965599 )
2015
31
A low fibrillatory wave amplitude predicts sinus node dysfunction after catheter ablation in patients with persistent atrial fibrillation. ( 26003808 )
2015
32
Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction. ( 26044937 )
2015
33
CHA2DS2-VAS(C) and CHADS2 Scores Predict Adverse Clinical Events in Patients With Pacemakers and Sinus Node Dysfunction Independent of Atrial Fibrillation. ( 26076964 )
2015
34
It's all in your head: sinus node dysfunction secondary to a sphenoid wing meningioma. ( 26141412 )
2015
35
Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. ( 26770873 )
2015
36
H1N1-associated sinus node dysfunction. ( 27326207 )
2015
37
Exome sequencing identifies a novel mutation in the MYH6 gene in a family with early-onset sinus node dysfunction, ventricular arrhythmias, and cardiac arrest. ( 28491533 )
2015
38
Fibrosis, electrics and genetics. Perspectives in sinoatrial node disease. ( 24837708 )
2014
39
Severe sinus node dysfunction in a patient with juvenile neuronal ceroid lipofuscinosis. ( 24726208 )
2014
40
Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial. ( 24797760 )
2014
41
Sinus node dysfunction after partial anomalous pulmonary venous connection repair. ( 24060362 )
2014
42
Should catheter ablation be the preferred approach for treatment of atrial fibrillation related symptomatic sinus node dysfunction? ( 24456425 )
2014
43
The type of sinus node dysfunction might predict the severity of atrial remodeling and clinical outcome after catheter ablation of atrial fibrillation. ( 24512882 )
2014
44
Relationship between two arrhythmias: sinus node dysfunction and atrial fibrillation. ( 24825742 )
2014
45
Sinus node dysfunction and atrial fibrillation: which one dominates? ( 24912808 )
2014
46
Extracardiac autologous pericardial tunnel Fontan allows implantation of an endocardial atrial lead for sinus node dysfunction. ( 25193196 )
2014
47
Concealed Sinus Node Dysfunction and Paradoxical Effect of Atropine during Arrhythmia Diagnostic Pharmacological Testing. ( 25232283 )
2014
48
Fetal bradycardia and sinus node dysfunction. ( 22639004 )
2013
49
Sinus node dysfunction in atrial fibrillation patients: the evidence of regional atrial substrate remodelling. ( 22772055 )
2013
50
Sinus node dysfunction and atrial fibrillation: two sides of the same coin? ( 22906746 )
2013

Variations for Sinoatrial Node Disease

Expression for Sinoatrial Node Disease

Search GEO for disease gene expression data for Sinoatrial Node Disease.

Pathways for Sinoatrial Node Disease

GO Terms for Sinoatrial Node Disease

Cellular components related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 9.33 GJA1 GJA5 GJC1
2 T-tubule GO:0030315 9.32 KCNJ3 SCN5A
3 HCN channel complex GO:0098855 9.26 HCN2 HCN4
4 connexin complex GO:0005922 9.13 GJA1 GJA5 GJC1
5 intercalated disc GO:0014704 8.92 GJA1 GJA5 GJC1 SCN5A

Biological processes related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.93 GJA1 GJA5 GJC1 SHOX2
2 transmembrane transport GO:0055085 9.93 GJA1 GJA5 GJC1 HCN2 HCN4 SCN5A
3 cell-cell signaling GO:0007267 9.87 GJA1 GJC1 HCN2
4 regulation of ion transmembrane transport GO:0034765 9.87 HCN2 HCN4 KCNJ3 SCN5A
5 in utero embryonic development GO:0001701 9.86 GJA1 MYH6 TBX3
6 potassium ion transport GO:0006813 9.85 GJA5 HCN2 HCN4 KCNJ3
7 skeletal system development GO:0001501 9.84 GJA5 SHOX2 TBX3
8 sodium ion transport GO:0006814 9.83 HCN2 HCN4 SCN5A
9 sodium ion transmembrane transport GO:0035725 9.81 HCN2 HCN4 SCN5A
10 muscle contraction GO:0006936 9.8 GJA1 GJC1 HCN4 MYH6
11 cell communication GO:0007154 9.78 GJA1 GJA5 GJC1
12 potassium ion import across plasma membrane GO:1990573 9.75 HCN2 HCN4 KCNJ3
13 regulation of heart rate GO:0002027 9.73 HCN4 MYH6 SCN5A
14 cardiac muscle contraction GO:0060048 9.7 MYH6 SCN5A
15 ventricular septum morphogenesis GO:0060412 9.69 GJA5 TBX3
16 regulation of heart contraction GO:0008016 9.69 GJA1 MYH6
17 embryonic forelimb morphogenesis GO:0035115 9.69 SHOX2 TBX3
18 positive regulation of vasoconstriction GO:0045907 9.68 GJA1 GJA5
19 positive regulation of blood vessel diameter GO:0097755 9.68 GJA1 GJA5
20 decidualization GO:0046697 9.68 CYP27B1 GJA1
21 regulation of bone mineralization GO:0030500 9.67 CYP27B1 GJA1
22 regulation of cardiac muscle contraction GO:0055117 9.67 GJA5 HCN4
23 ventricular cardiac muscle cell action potential GO:0086005 9.66 GJA5 SCN5A
24 adult heart development GO:0007512 9.65 GJA1 MYH6
25 sodium ion import across plasma membrane GO:0098719 9.65 HCN2 HCN4
26 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.65 GJA1 GJA5
27 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 GJA1 GJA5 SCN5A
28 cardiac conduction GO:0061337 9.64 GJA1 GJA5
29 cellular response to cGMP GO:0071321 9.63 HCN2 HCN4
30 endothelium development GO:0003158 9.62 GJA1 GJA5
31 cell communication by electrical coupling GO:0010644 9.62 GJA1 GJA5
32 membrane depolarization during SA node cell action potential GO:0086046 9.61 HCN4 SCN5A
33 embryonic heart tube development GO:0035050 9.61 GJA1 GJA5 TBX3
34 AV node cell to bundle of His cell communication GO:0086067 9.6 GJA5 SCN5A
35 AV node cell to bundle of His cell communication by electrical coupling GO:0086053 9.59 GJA5 GJC1
36 cell communication by chemical coupling GO:0010643 9.58 GJA1 GJA5
37 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.58 HCN2 HCN4 SCN5A
38 atrial ventricular junction remodeling GO:0003294 9.54 GJA1 GJA5
39 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.54 GJA1 GJA5 SCN5A
40 positive regulation of cell communication by chemical coupling GO:0010652 9.52 GJA1 GJA5
41 SA node cell to atrial cardiac muscle cell communication by electrical coupling GO:0086021 9.51 GJA5 GJC1
42 atrial cardiac muscle cell action potential GO:0086014 9.5 GJA1 GJC1 SCN5A
43 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.43 GJA1 GJA5 SCN5A
44 gap junction assembly GO:0016264 9.33 GJA1 GJA5 GJC1
45 SA node cell action potential GO:0086015 9.13 GJA5 HCN4 SCN5A
46 regulation of heart rate by cardiac conduction GO:0086091 8.92 GJA5 HCN4 KCNJ3 SCN5A
47 ion transport GO:0006811 10 HCN2 HCN4 KCNJ3 SCN5A

Molecular functions related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.67 GJC1 HCN2 HCN4 SCN5A
2 disordered domain specific binding GO:0097718 9.51 GJA1 GJA5
3 cAMP binding GO:0030552 9.49 HCN2 HCN4
4 intracellular cAMP-activated cation channel activity GO:0005222 9.48 HCN2 HCN4
5 connexin binding GO:0071253 9.46 GJA1 GJA5
6 voltage-gated ion channel activity GO:0005244 9.46 HCN2 HCN4 KCNJ3 SCN5A
7 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GO:0086077 9.43 GJA5 GJC1
8 sodium channel activity GO:0005272 9.43 HCN2 HCN4 SCN5A
9 gap junction channel activity involved in cardiac conduction electrical coupling GO:0086075 9.4 GJA1 GJA5
10 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling GO:0086020 9.32 GJA5 GJC1
11 voltage-gated sodium channel activity GO:0005248 9.13 HCN2 HCN4 SCN5A
12 gap junction channel activity GO:0005243 8.8 GJA1 GJA5 GJC1

Sources for Sinoatrial Node Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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