MCID: SNT005
MIFTS: 49

Sinoatrial Node Disease

Categories: Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Sinoatrial Node Disease

MalaCards integrated aliases for Sinoatrial Node Disease:

Name: Sinoatrial Node Disease 12 15
Sinus Node Dysfunction 71
Sinuatrial Node 12
Sa Node 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050824
UMLS 71 C0428908

Summaries for Sinoatrial Node Disease

Disease Ontology : 12 A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.

MalaCards based summary : Sinoatrial Node Disease, also known as sinus node dysfunction, is related to third-degree atrioventricular block and syncope. An important gene associated with Sinoatrial Node Disease is HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4), and among its related pathways/superpathways are G-Beta Gamma Signaling and cGMP-PKG signaling pathway. The drugs Sotalol and Tocolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 74 The sinoatrial node (also known as the SA node or the sinus node) is a group of cells located in the... more...

Related Diseases for Sinoatrial Node Disease

Diseases related to Sinoatrial Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 third-degree atrioventricular block 32.0 TBX18 SCN5A SCN1B HCN4 GJA5 CACNA1D
2 syncope 30.6 SCN5A RYR2 KCNH2
3 cardiac arrhythmia 29.8 SCN5A RYR2 KCNH2 CACNA1C ANK2
4 sick sinus syndrome 29.4 TBX18 SCN5A SCN3B SCN1B MYH6 HCN4
5 atrioventricular block 29.1 SCN5A RYR2 NKX2-5 KCNH2 HCN4 GJC1
6 atrial fibrillation 28.6 SCN5A SCN3B SCN1B RYR2 KCNH2 HCN4
7 chronic atrial and intestinal dysrhythmia 11.6
8 cardiac arrhythmia, ankyrin-b-related 11.5
9 multifocal atrial tachycardia 11.5
10 atrial standstill 10.6 SCN5A GJA5
11 first-degree atrioventricular block 10.4 SCN5A GJA5 GJA1
12 hallermann-streiff syndrome 10.4 GJC1 GJA1
13 familial sick sinus syndrome 10.4 SCN5A MYH6 HCN4
14 progressive familial heart block, type ia 10.4 SCN5A GJA5 ANK2
15 brugada syndrome 3 10.3 CACNA1C ANK2
16 testicular thecoma 10.3 GJD3 GJC3
17 hereditary lymphedema ic 10.3 SCN5A GJC1 GJA5 GJA1
18 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.3
19 hypokalemic periodic paralysis, type 1 10.3 SCN5A CACNA1D CACNA1C
20 long qt syndrome 9 10.3 SCN5A CACNA1C ANK2
21 knuckle pads, leukonychia, and sensorineural deafness 10.3 GJC3 GJC1 GJA1
22 brugada syndrome 1 10.3 SCN5A RYR2 KCNH2
23 familial long qt syndrome 10.3 SCN5A KCNH2 CACNA1C
24 long qt syndrome 13 10.2 SCN5A KCNH2 ANK2
25 erythrokeratodermia variabilis et progressiva 1 10.2 GJC3 GJC1 GJA1
26 anhidrosis, isolated, with normal sweat glands 10.2 RYR2 CACNA1C
27 long qt syndrome 12 10.2 SCN5A KCNH2 ANK2
28 long qt syndrome 10 10.2 SCN5A KCNH2 ANK2
29 long qt syndrome 14 10.2 SCN1B ANK2
30 long qt syndrome 11 10.2 CACNA1C ANK2
31 heart, malformation of 10.2 NKX2-5 MYH6
32 long qt syndrome 15 10.2 SCN3B SCN1B
33 ulnar-mammary syndrome 10.2 TBX3 TBX18 NKX2-5
34 oculodentodigital dysplasia 10.2 GJC3 GJC1 GJA5 GJA1
35 brugada syndrome 5 10.2 SCN5A SCN1B
36 polykaryocytosis inducer 10.2
37 posttransplant acute limbic encephalitis 10.2
38 leukodystrophy, hypomyelinating, 2 10.1 GJD3 GJC3 GJC1 GJA1
39 malignant hyperthermia 10.1 SCN5A RYR2 MYH6 CACNA1C
40 epileptic encephalopathy, early infantile, 6 10.1 SCN5A SCN3B SCN1B
41 brugada syndrome 4 10.1 SCN5A KCNH2 CACNA1D CACNA1C
42 generalized epilepsy with febrile seizures plus 10.1 SCN5A SCN3B SCN1B
43 cardiac conduction defect 10.1 SCN5A SCN1B RYR2 KCNH2
44 congestive heart failure 10.1 SCN5A RYR2 MYH6 CACNA1C
45 long qt syndrome 6 10.1 SCN5A KCNH2 CACNA1C ANK2
46 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 10.1 SCN5A RYR2 KCNH2 ANK2
47 second-degree atrioventricular block 10.1 SCN5A SCN3B HCN4 GJA1 CACNA1D
48 jervell and lange-nielsen syndrome 1 10.1 SCN5A KCNH2 CACNA1C ANK2
49 progressive familial heart block 10.1 SCN5A SCN1B NKX2-5 GJA5
50 leopard syndrome 10.1 MYH6 KCNH2 CACNA1C

Comorbidity relations with Sinoatrial Node Disease via Phenotypic Disease Network (PDN): (show all 47)


Acute Cystitis Acute Kidney Failure
Anxiety Aortic Valve Disease 1
Atrioventricular Block Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Cerebral Atherosclerosis Cerebrovascular Disease
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Gout Heart Disease
Hypertension, Essential Hypertrophic Cardiomyopathy
Hypoglycemia Hypothyroidism
Idiopathic Peripheral Autonomic Neuropathy Intermediate Coronary Syndrome
Intracranial Embolism Kidney Disease
Left Bundle Branch Hemiblock Malignant Essential Hypertension
Mitral Valve Disease Mitral Valve Stenosis
Mobitz Type Ii Atrioventricular Block Monocular Esotropia
Nutmeg Liver Peripheral Vascular Disease
Progressive Familial Heart Block, Type Ia Pulmonary Hypertension, Primary, 1
Pulmonary Valve Disease Rheumatic Heart Disease
Right Bundle Branch Block Schizophreniform Disorder
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1
Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Sinoatrial Node Disease:



Diseases related to Sinoatrial Node Disease

Symptoms & Phenotypes for Sinoatrial Node Disease

MGI Mouse Phenotypes related to Sinoatrial Node Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 CACNA1C CACNA1D GJA1 GJA5 GJC1 GJC3
2 mortality/aging MP:0010768 10.22 CACNA1C CACNA1D GJA1 GJA5 GJC1 GJD3
3 growth/size/body region MP:0005378 10.15 CACNA1D GJA1 GJC1 KCNH2 NKX2-5 RYR2
4 muscle MP:0005369 10.07 CACNA1C GJA1 GJA5 GJC1 HCN4 KCNH2
5 embryo MP:0005380 10.06 CACNA1C GJA1 GJC1 KCNH2 NKX2-5 RYR2
6 nervous system MP:0003631 9.97 CACNA1C CACNA1D GJA1 GJC1 GJC3 GJD3
7 no phenotypic analysis MP:0003012 9.56 GJA1 GJA5 GJC1 GJD3 NKX2-5 RYR2
8 normal MP:0002873 9.23 GJA1 GJA5 HCN4 NKX2-5 RYR2 SCN1B

Drugs & Therapeutics for Sinoatrial Node Disease

Drugs for Sinoatrial Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
2 Tocolytic Agents Phase 4
3 Adrenergic Agonists Phase 4
4 Anti-Asthmatic Agents Phase 4
5 Adrenergic beta-Agonists Phase 4
6 Respiratory System Agents Phase 4
7 Bronchodilator Agents Phase 4
8 Albuterol Phase 4
9 Anti-Arrhythmia Agents Phase 4
10 Adrenergic beta-Antagonists Phase 4
11 Neurotransmitter Agents Phase 4
12 Autonomic Agents Phase 4
13 Adrenergic Agents Phase 4
14 Adrenergic Antagonists Phase 4
15 Sodium Channel Blockers Phase 4
16 Diuretics, Potassium Sparing Phase 4
17 Sympatholytics Phase 4
18
Irbesartan Approved, Investigational Phase 3 138402-11-6 3749
19
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198
20 Antihypertensive Agents Phase 3
21 Giapreza Phase 3
22 Angiotensin II Type 1 Receptor Blockers Phase 3
23 Angiotensin Receptor Antagonists Phase 3
24 Angiotensinogen Phase 3
25
Losartan Approved 114798-26-4 3961
26
tannic acid Approved 1401-55-4
27
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
28
Amiodarone Approved, Investigational 1951-25-3 2157
29
Dronedarone Approved 141626-36-0, 141625-93-6 154087
30
Digoxin Approved 20830-75-5 30322 2724385
31
Propafenone Approved 54063-53-5 4932
32 Vasoactive intestinal peptide 40077-57-4
33 neurokinin A
34
Substance P 33507-63-0 44359816

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Prevention of Atrial Arrhythmia in Patients Without AV Conduction Disease Completed NCT01170611 Phase 4
2 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
3 Investigational New Drug Application/ Investigational Device Exemption Information Completed NCT00239226 Phase 4
4 CLEAR: Cylos Pacemaker Responds With Physiologic Rate Changes During Daily Activities Completed NCT00355797 Phase 4
5 The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Ventrucular Septal Defect Patients With Persistant or Surgically Corrected Conditions - The VENTI Trial Completed NCT02914652 Phase 4 Salbutamol;Norflouran (Placebo Evohaler(R) )
6 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
7 Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension, Permanent Pacemakers and Risk Factors for Developing Atrial Fibrillation Unknown status NCT00225667 Phase 3 Irbesartan
8 A Prospective Canadian Multi-Center Randomized Study; Spontaneous AtrioVEntricular Conduction PReservation Completed NCT01219621 Phase 3
9 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
10 Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome (a Double-blind Placebo-parallel Group Trial) Recruiting NCT03182725 Phase 3 Ivabradine;Placebo
11 A Randomized Trial of Closed Loop Stimulation After Epicardial Pacemaker Implantation for Congenital Heart Disease Not yet recruiting NCT03361189 Phase 2, Phase 3
12 Second Study on Cardio-neuromodulation in Humans Unknown status NCT02954666 Phase 2
13 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
14 Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia Unknown status NCT01310907
15 The Effect of Losartan on Atrial Fibrillation and Pacemaker Dependence in Sick Sinus Syndrome (SSS) Patients Receiving Physiological Pacemaker - A Prospective, Randomized, Multicenter Study in Taiwan Unknown status NCT00647257 Losartan;Placebo
16 INGEVITY(TM) Active Fixation and Passive Fixation Pace/ Sense Lead Clinical Study Completed NCT01688843
17 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction. Completed NCT02027909
18 Effectiveness of Closed Loop Stimulation (CLS) With His Bundle Lead Placement Completed NCT03601754
19 Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858
20 Right Ventricular Outflow Tract Septal Pacing for Cardiac Dysfunction Prevention Evaluation Completed NCT01294839
21 Evolution of the PR Interval in Patients Implanted With a Dual Chamber Pacemaker With Algorithm for Spontaneous AV Conduction Preservation Completed NCT02586480
22 Response to Cardiac Resynchronization Therapy of Previously Right Ventricular Paced Heart Failure Patients Completed NCT01466621
23 Promotion of Coronary Collateral Function by Ivabradine-Induced Bradycardia in Patients With Coronary Artery Disease Completed NCT01039389 Ivabradine;Placebo
24 Selective Vagus Nerve Stimulation in Human Completed NCT00983632
25 An Investigation Into The Potential Roles Of Vasoactive Intestinal Peptide And Substance P In The Pathophysiology Of Plastic Bronchitis And Protein Losing Enteropathy In Children With Palliated Single Ventricle Physiology Completed NCT01563757
26 Ablation of Inappropriate Sinus Tachycardia Syndrome by Targeting Cardiac Neural Input Recruiting NCT00584649
27 BIO|REDUCE: Cardiac REsynchronization Therapy With Two Ventricular Leads and Right Atrial Floating Diagnostic Dipole Installed in the Right ventricUlar Lead in Patients With CRT-D indiCation and no Sinus nodE Dysfunction Recruiting NCT03839121
28 Cleveland Clinic Arrhythmia Biospecimen Repository (Cleveland Clinic Arrhythmia BioBank) Recruiting NCT00921986
29 ATrial Tachycardia PAcing Therapy in Congenital Heart Recruiting NCT03209583
30 Clinical Benefits of the Closed Loop Stimulation in Sinus Node Disease - B3 Study Recruiting NCT02579889
31 A Retrospective Trial to Evaluate the Micra Pacemaker Recruiting NCT04051814
32 Evaluation of Ventricular Pacing Suppression Algorithms in Dual Chamber Recruiting NCT03843242
33 Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope Recruiting NCT01814228
34 Sudden Cardiac Death in Congenital Heart Diseases With a Systemic Right Ventricle Recruiting NCT03833843
35 The Changes in The Right Ventricular Function After Elective Percutaneous Coronary Intervention in Patients With Right Coronary Artery Occlusion Recruiting NCT03543345
36 Comparison of the Self-invented Intracavitary ECG Wire With the Commercial System - Certodyn® Recruiting NCT03697291
37 Stepwise Atrial Fibrillation supprEssion Treatment in Patients With Paroxysmal Atrial Fibrillation and Sinus Node Dysfunction: Intensive Device Follow-up Active, not recruiting NCT03607123 Anti arryhthmic drugs
38 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Active, not recruiting NCT01643707
39 Evaluation of AV Delay Optimization vs. Intrinsic Conduction in Patients With Long PR Intervals Receiving Dual Chamber Pacemakers for Symptomatic Bradycardia Active, not recruiting NCT02154750
40 Fluoroless Permanent HIS Bundle Pacing Utilizing Electro-anatomic Mapping Versus Conventional Implantation Not yet recruiting NCT03903107
41 Cardiac Ganglionated Plexus Ablation Before Permanent Pacemaker Implantation in Patients With Sick Sinus Syndrome - A Multicenter, Randomized, Prospective Clinical Trial Not yet recruiting NCT04149886
42 A Single Center, Retrospective Study of the Safety and Feasibility of Epicardial Biventricular Pacing in the Pediatric Population Terminated NCT00267423
43 Effect of Atrial Pacing on Right Ventricular Function After Cardiac Surgery Withdrawn NCT04151745

Search NIH Clinical Center for Sinoatrial Node Disease

Genetic Tests for Sinoatrial Node Disease

Anatomical Context for Sinoatrial Node Disease

MalaCards organs/tissues related to Sinoatrial Node Disease:

40
Heart, Testes, Atrioventricular Node, Endothelial, Bone, Brain, B Cells

Publications for Sinoatrial Node Disease

Articles related to Sinoatrial Node Disease:

(show top 50) (show all 1437)
# Title Authors PMID Year
1
Cardiac Sarcoidosis multi-center randomized controlled trial (CHASM CS- RCT). 61
31911261 2020
2
Sick Sinus Syndrome: Sinus Node Dysfunction in the Elderly. 61
31939855 2020
3
Repair of Superior Sinus Venosus Atrial Septal Defect Using a Modified Two-Patch Technique. 61
31472131 2020
4
Robotic repair of partial anomalous pulmonary venous connection: the initial experience and technical details. 61
30828770 2020
5
Outcomes of Double-patch and Warden Techniques in Patients With Supracardiac Partial Anomalous Pulmonary Venous Connection. 61
30686643 2020
6
Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function. 61
32023981 2020
7
Usefulness of an Implantable Loop Recorder in Diagnosing Unexplained Syncope and Predictors for Pacemaker Implantation. 61
31920017 2020
8
[Myotonic dystrophy type 1 - a rare cause of bradycardia in the young]. 61
31961442 2020
9
Initial experience with ablation of the innervation surrounding sinus and atrioventricular nodes to treat paroxysmal bradyarrhythmia. 61
31880742 2020
10
Outcomes of the Warden Procedure for Partial Anomalous Pulmonary Venous Drainage. 61
31811329 2020
11
In silico study of the effects of anti-arrhythmic drug treatment on sinoatrial node function for patients with atrial fibrillation. 61
31941982 2020
12
Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation. 61
32030263 2019
13
Severe congenital RYR1-associated myopathy complicated with atrial tachycardia and sinus node dysfunction: a case report. 61
31856875 2019
14
Prospective evaluation of feasibility and electrophysiologic and echocardiographic characteristics of left bundle branch area pacing. 61
31136869 2019
15
Left bundle branch pacing for symptomatic bradycardia: Implant success rate, safety, and pacing characteristics. 61
31125667 2019
16
Permanent Pacemaker Implantations after Catheter Ablation in Patients with Atrial Fibrillation Associated with Underlying Sinus Node Dysfunction. 61
31960638 2019
17
Evaluation of a near-zero fluoroscopic approach for catheter ablation in patients with congenital heart disease. 61
30377927 2019
18
When two hearts do not beat as one - An unusual cause of pacemaker related tachycardia. 61
31442564 2019
19
Exome reports A de novo GNB2 variant associated with global developmental delay, intellectual disability, and dysmorphic features. 61
31698099 2019
20
An unusual pacing artifact. 61
31582675 2019
21
Voltage mapping to guide pacemaker placement in patients with CHD. 61
31475646 2019
22
Sick Sinus Syndrome: Sinus Node Dysfunction in the Elderly. 61
31625958 2019
23
Slow and steady or fast and furious? Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia. 61
31231896 2019
24
A 45-year experience with the Fontan procedure: tachyarrhythmia, an important sign for adverse outcome. 61
31038168 2019
25
A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation. 61
31350002 2019
26
MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels. 61
31302118 2019
27
Trastuzumab-Induced Cardiomyopathy and Intermittent Left Bundle Branch Block. 61
31413780 2019
28
Initial experience with transcatheter pacemaker implantation for adults with congenital heart disease. 61
31045294 2019
29
Intra-Atrial Block: Definition and Relationship to Atrial Fibrillation and Other Adverse Outcomes. 61
32002116 2019
30
Surgical Outcomes of Permanent Epicardial Pacing in Neonates and Young Infants Less Than 1 Year of Age. 61
30064922 2019
31
Etiology of tricuspid valve disease is a predictor of bradyarrhythmia after tricuspid valve surgery. 61
30938919 2019
32
Pacemaker treatment after Fontan surgery-A Swedish national study. 61
30883035 2019
33
Dual Sinus Nodes With Donor Sinus Node Dysfunction in Biatrial Heart Transplantation. 61
31107496 2019
34
Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice. 61
31320323 2019
35
Challenges in Bradicardias Interpretation. 61
31084850 2019
36
Cardiac Rhythm Disturbances in Heterotaxy Syndrome. 61
30877320 2019
37
Clinical characteristics and rhythm outcome of catheter ablation of hemodynamically corrected valvular atrial fibrillation. 61
30850308 2019
38
Enhanced closed-state inactivation of mutant cardiac sodium channels (SCN5A N1541D and R1632C) through different mechanisms. 61
30935997 2019
39
Fetal arrhythmias: Diagnosis and management. 61
30817991 2019
40
Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia. 61
30615235 2019
41
Leadless pacemaker implantation: A feasible and reasonable option in transcatheter heart valve replacement patients. 61
30829416 2019
42
Superior vena cava syndrome due to pacemaker leads: an Indian report with a review of management practices. 61
30968668 2019
43
Sinus node dysfunction in patients with Fontan circulation: could heart rate variability be a predictor for pacemaker implantation? 61
30918992 2019
44
Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. 61
30764634 2019
45
[Clinical characteristics and treatment of congenital long QT syndrome in 58 children]. 61
30934199 2019
46
Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome. 61
30975291 2019
47
Permanent pacemaker implantation after pediatric heart transplantation: Risk factors, indications, and outcomes. 61
30790343 2019
48
Atrial fibrillation occurring during head-up tilt testing: Once detected, atrial fibrillation should be monitored, regardless of how it is detected. 61
30528450 2019
49
Dysrhythmias in patients with a complete atrioventricular septal defect: From surgery to early adulthood. 61
30485659 2019
50
Occurrence of significant long PR intervals in patients implanted for sinus node dysfunction and monitored with SafeR™: The PRECISE study. 61
30594571 2019

Variations for Sinoatrial Node Disease

Expression for Sinoatrial Node Disease

Search GEO for disease gene expression data for Sinoatrial Node Disease.

Pathways for Sinoatrial Node Disease

Pathways related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 SCN5A SCN3B SCN1B GJC1 GJA5 GJA1
2
Show member pathways
12.38 SCN5A SCN1B RYR2 MYH6 CACNA1D CACNA1C
3
Show member pathways
12.34 RYR2 GJC1 GJA5 GJA1 CACNA1D CACNA1C
4
Show member pathways
12.34 SCN5A SCN3B SCN1B RYR2 NKX2-5 MYH6
5 12.19 RYR2 HCN4 CACNA1D CACNA1C
6
Show member pathways
12.12 RYR2 MYH6 CACNA1D CACNA1C
7 12.04 SCN5A SCN3B RYR2 KCNH2 GJA1
8
Show member pathways
12 RYR2 GJA1 CACNA1D CACNA1C
9
Show member pathways
11.89 SCN5A SCN3B SCN1B ANK2
10
Show member pathways
11.77 GJD3 GJC1 GJA5 GJA1
11 11.69 RYR2 MYH6 CACNA1D CACNA1C
12 11.44 SCN5A NKX2-5 MYH6
13
Show member pathways
11.43 SCN5A SCN3B SCN1B CACNA1D CACNA1C
14 11.39 RYR2 CACNA1D CACNA1C
15 11.15 SCN5A SCN3B SCN1B RYR2 KCNH2 HCN4
16 11.03 SCN5A SCN3B SCN1B ANK2
17 10.85 HCN4 GJA1
18 10.65 CACNA1D CACNA1C

GO Terms for Sinoatrial Node Disease

Cellular components related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.31 SCN5A SCN3B SCN1B RYR2 KCNH2 HCN4
2 plasma membrane GO:0005886 10.27 SCN5A SCN3B SCN1B RYR2 KCNH2 HCN4
3 cell junction GO:0030054 9.98 GJD3 GJC3 GJC1 GJA5 GJA1 CACNA1C
4 sarcolemma GO:0042383 9.71 SCN5A RYR2 CACNA1C ANK2
5 gap junction GO:0005921 9.65 GJD3 GJC3 GJC1 GJA5 GJA1
6 T-tubule GO:0030315 9.62 SCN5A SCN1B CACNA1C ANK2
7 connexin complex GO:0005922 9.55 GJD3 GJC3 GJC1 GJA5 GJA1
8 voltage-gated sodium channel complex GO:0001518 9.54 SCN5A SCN3B SCN1B
9 Z disc GO:0030018 9.5 SCN5A SCN3B RYR2 MYH6 CACNA1D CACNA1C
10 L-type voltage-gated calcium channel complex GO:1990454 9.48 CACNA1D CACNA1C
11 intercalated disc GO:0014704 9.1 SCN5A SCN1B GJC1 GJA5 GJA1 ANK2

Biological processes related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.22 SCN5A RYR2 KCNH2 HCN4 GJD3 GJC1
2 ion transport GO:0006811 10.21 SCN5A SCN3B SCN1B RYR2 KCNH2 HCN4
3 ion transmembrane transport GO:0034220 10.1 SCN5A RYR2 GJD3 GJC1 GJA1 CACNA1D
4 heart development GO:0007507 10.09 SHOX2 NKX2-5 GJC1 GJA5 GJA1 CACNA1C
5 regulation of ion transmembrane transport GO:0034765 10.08 SCN5A SCN3B SCN1B KCNH2 HCN4 CACNA1D
6 sodium ion transport GO:0006814 9.99 SCN5A SCN3B SCN1B HCN4
7 muscle contraction GO:0006936 9.97 MYH6 HCN4 GJC1 GJA1
8 cell communication GO:0007154 9.97 GJD3 GJC3 GJC1 GJA5 GJA1
9 regulation of heart rate GO:0002027 9.96 SCN5A RYR2 MYH6 HCN4 ANK2
10 sodium ion transmembrane transport GO:0035725 9.93 SCN5A SCN3B SCN1B HCN4
11 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.91 SCN5A SCN1B KCNH2 GJA5 ANK2
12 outflow tract morphogenesis GO:0003151 9.88 TBX3 NKX2-5 GJA5
13 positive regulation of sodium ion transport GO:0010765 9.88 SCN5A SCN3B SCN1B NKX2-5
14 regulation of cardiac muscle contraction GO:0055117 9.88 RYR2 NKX2-5 HCN4 GJA5 ANK2
15 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.87 SCN5A SCN3B SCN1B GJA5
16 cardiac conduction GO:0061337 9.87 SCN5A SCN3B SCN1B KCNH2 GJA5 CACNA1D
17 ventricular septum morphogenesis GO:0060412 9.86 TBX3 NKX2-5 GJA5
18 embryonic forelimb morphogenesis GO:0035115 9.85 TBX3 SHOX2 CACNA1C
19 gap junction assembly GO:0016264 9.85 GJD3 GJC1 GJA5 GJA1
20 cardiac muscle cell action potential involved in contraction GO:0086002 9.85 SCN5A SCN3B SCN1B CACNA1D CACNA1C
21 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.83 RYR2 GJD3 GJA5 GJA1 CACNA1C
22 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.82 RYR2 CACNA1C ANK2
23 membrane depolarization GO:0051899 9.82 SCN5A SCN3B SCN1B
24 embryonic heart tube development GO:0035050 9.81 TBX3 NKX2-5 GJA5
25 membrane depolarization during action potential GO:0086010 9.8 SCN5A SCN3B KCNH2
26 membrane depolarization during SA node cell action potential GO:0086046 9.8 SCN5A HCN4 CACNA1D ANK2
27 atrial cardiac muscle cell action potential GO:0086014 9.8 SCN5A SCN3B GJC1 GJA1 ANK2
28 cardiac muscle contraction GO:0060048 9.8 SCN5A SCN3B SCN1B RYR2 NKX2-5 MYH6
29 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.79 SCN5A SCN3B GJA5
30 regulation of atrial cardiac muscle cell action potential GO:0098910 9.77 RYR2 GJA5 ANK2
31 AV node cell to bundle of His cell communication by electrical coupling GO:0086053 9.77 GJC3 GJC1 GJA5
32 SA node cell action potential GO:0086015 9.77 SCN5A SCN3B HCN4 GJA5 ANK2
33 regulation of potassium ion transmembrane transport GO:1901379 9.73 KCNH2 CACNA1D
34 calcium ion transport into cytosol GO:0060402 9.72 RYR2 CACNA1C
35 adult heart development GO:0007512 9.72 NKX2-5 MYH6
36 regulation of cardiac muscle cell contraction GO:0086004 9.72 SCN5A ANK2
37 atrial septum morphogenesis GO:0060413 9.72 NKX2-5 GJA5
38 positive regulation of stem cell proliferation GO:2000648 9.72 TBX3 GJA1
39 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.71 RYR2 CACNA1C
40 positive regulation of adenylate cyclase activity GO:0045762 9.71 CACNA1D CACNA1C
41 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.71 RYR2 ANK2
42 cell communication by electrical coupling GO:0010644 9.71 GJA5 GJA1
43 atrial septum development GO:0003283 9.71 GJA5 ANK2
44 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.7 SCN5A CACNA1D
45 endothelium development GO:0003158 9.7 GJA5 GJA1
46 membrane depolarization during AV node cell action potential GO:0086045 9.7 SCN5A CACNA1C
47 sarcoplasmic reticulum calcium ion transport GO:0070296 9.69 RYR2 ANK2
48 cardiac conduction system development GO:0003161 9.69 NKX2-5 GJA5
49 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.68 SCN5A CACNA1C
50 regulation of AV node cell action potential GO:0098904 9.68 RYR2 GJA5

Molecular functions related to Sinoatrial Node Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.86 SCN5A RYR2 MYH6 CACNA1C
2 ion channel binding GO:0044325 9.85 SCN5A SCN3B SCN1B RYR2 ANK2
3 calcium channel activity GO:0005262 9.75 RYR2 CACNA1D CACNA1C
4 sodium channel activity GO:0005272 9.73 SCN5A SCN3B SCN1B HCN4
5 voltage-gated sodium channel activity GO:0005248 9.67 SCN5A SCN3B SCN1B HCN4
6 alpha-actinin binding GO:0051393 9.58 CACNA1D CACNA1C
7 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.58 SCN5A SCN3B SCN1B
8 high voltage-gated calcium channel activity GO:0008331 9.57 CACNA1D CACNA1C
9 connexin binding GO:0071253 9.55 GJA5 GJA1
10 sodium channel inhibitor activity GO:0019871 9.54 SCN3B SCN1B
11 gap junction hemi-channel activity GO:0055077 9.52 GJA5 GJA1
12 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.51 CACNA1D CACNA1C
13 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GO:0086077 9.5 GJC3 GJC1 GJA5
14 ion channel activity GO:0005216 9.5 SCN5A RYR2 KCNH2 HCN4 GJD3 GJC1
15 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.49 SCN5A SCN1B
16 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling GO:0086020 9.48 GJC1 GJA5
17 gap junction channel activity GO:0005243 9.46 GJD3 GJC1 GJA5 GJA1
18 gap junction channel activity involved in cardiac conduction electrical coupling GO:0086075 9.43 GJD3 GJA5 GJA1
19 voltage-gated ion channel activity GO:0005244 9.17 SCN5A SCN3B SCN1B KCNH2 HCN4 CACNA1D

Sources for Sinoatrial Node Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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