MCID: SNN002
MIFTS: 32

Sinonasal Undifferentiated Carcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

MalaCards integrated aliases for Sinonasal Undifferentiated Carcinoma:

Name: Sinonasal Undifferentiated Carcinoma 53 73
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 53
Snuc 53

Classifications:



External Ids:

UMLS 73 C1710096

Summaries for Sinonasal Undifferentiated Carcinoma

NIH Rare Diseases : 53 Sinonasal undifferentiated carcinoma (SNUC) is a type of cancer that develops in the sinuses of the head. SNUC occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass. The first symptoms of SNUC may include difficulty breathing though the nose or mild facial pain. As SNUC progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face. SNUC is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis). The cause of SNUC is still unknown. When possible, the treatment is the complete removal of the tumor, combined with radiation therapy and chemotherapy. In cases where the tumor can't be removed completely, the treatment is with radiation and chemotherapy. The risk of the tumor coming back (relapse) is high and the probability of cure is modest.

MalaCards based summary : Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to olfactory neuroblastoma and pilomatrix carcinoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Citrate cycle (TCA cycle). The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord.

Wikipedia : 76 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Related Diseases for Sinonasal Undifferentiated Carcinoma

Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 olfactory neuroblastoma 30.2 ENO2 SYP
2 pilomatrix carcinoma 10.4 ENO2 MUC1
3 intracranial cysts 10.4 ENO2 MUC1
4 epithelioid malignant peripheral nerve sheath tumor 10.3 ENO2 MUC1
5 microcystic adenoma 10.3 ENO2 MUC1
6 ossifying fibromyxoid tumor 10.3 ENO2 MUC1
7 lymphoepithelioma-like carcinoma 10.3 ENO2 MUC1
8 meningeal melanocytoma 10.3 ENO2 MUC1
9 duodenum cancer 10.2 ENO2 MUC1
10 endometrial mucinous adenocarcinoma 10.2 MKI67 MUC1
11 pericardial mesothelioma 10.2 ENO2 MUC1
12 aggressive digital papillary adenocarcinoma 10.2 CEACAM3 MUC1
13 pilomatrixoma 10.2 ENO2 MUC1
14 bile duct adenocarcinoma 10.1 IDH2 MUC1
15 ureter small cell carcinoma 10.1 ENO2 SYP
16 malignant sertoli cell tumor 10.1 ENO2 SYP
17 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
18 auditory system cancer 10.1 ENO2 SYP
19 sensory organ benign neoplasm 10.1 ENO2 SYP
20 gallbladder small cell carcinoma 10.1 ENO2 SYP
21 pancreatic somatostatinoma 10.1 ENO2 SYP
22 cutaneous ganglioneuroma 10.1 ENO2 SYP
23 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
24 small cell carcinoma of the bladder 10.1 ENO2 SYP
25 orbital cancer 10.1 ENO2 SYP
26 ovarian carcinosarcoma 10.1 ENO2 SYP
27 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP
28 atypical follicular adenoma 10.1 ENO2 SYP
29 neuroblastoma 10.1
30 central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
31 cerebellum cancer 10.1 ENO2 SYP
32 subependymal glioma 10.1 ENO2 SYP
33 olfactory nerve neoplasm 10.1 ENO2 SYP
34 cerebral neuroblastoma 10.1 ENO2 SYP
35 cauda equina neoplasm 10.1 ENO2 SYP
36 extraosseous chondrosarcoma 10.1 ENO2 SYP
37 benign ependymoma 10.1 ENO2 SYP
38 malignant teratoma 10.1 ENO2 SYP
39 astroblastoma 10.1 ENO2 SYP
40 cerebral ventricle cancer 10.1 ENO2 SYP
41 cerebrum cancer 10.1 ENO2 SYP
42 pineal gland cancer 10.1 ENO2 SYP
43 endometrial small cell carcinoma 10.1 ENO2 SYP
44 melanotic neuroectodermal tumor 10.1 ENO2 SYP
45 nodular ganglioneuroblastoma 10.1 ENO2 SYP
46 supratentorial cancer 10.1 ENO2 SYP
47 pineocytoma 10.1 ENO2 SYP
48 respiratory system benign neoplasm 10.1 ENO2 SYP
49 angiomyoma 10.1 ENO2 SYP
50 gastric squamous cell carcinoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to Sinonasal Undifferentiated Carcinoma

Symptoms & Phenotypes for Sinonasal Undifferentiated Carcinoma

Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

Drugs for Sinonasal Undifferentiated Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
4
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
5
Ifosfamide Approved Phase 2 3778-73-2 3690
6
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
7
Fluorouracil Approved Phase 2 51-21-8 3385
8
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
9
Doxil Approved June 1999 Phase 2 31703
10
Isophosphamide mustard Phase 2 0
11 Alkylating Agents Phase 2
12 Topoisomerase Inhibitors Phase 2
13 Anti-Bacterial Agents Phase 2
14 Antibiotics, Antitubercular Phase 2
15 Pharmaceutical Solutions Phase 2
16 Etoposide phosphate Phase 2
17 Immunosuppressive Agents Phase 2
18 Antimetabolites Phase 2
19 Antimetabolites, Antineoplastic Phase 2
20 Antimitotic Agents Phase 2
21 Antineoplastic Agents, Alkylating Phase 2
22 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients Recruiting NCT02099188 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
2 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Operable Patients Recruiting NCT02099175 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
3 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

Anatomical Context for Sinonasal Undifferentiated Carcinoma

MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

41
Skin, Liver, Spinal Cord, Brain

Publications for Sinonasal Undifferentiated Carcinoma

Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50) (show all 93)
# Title Authors Year
1
A Case of Sinonasal Undifferentiated Carcinoma with Brain Metastases. ( 29755916 )
2018
2
Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study. ( 29935059 )
2018
3
Long-term follow-up of a patient with malignant transformation of inverted papilloma into sinonasal undifferentiated carcinoma. ( 29070275 )
2017
4
Spinal Cord Compression Secondary to Metastatic Sinonasal Undifferentiated Carcinoma. ( 28868018 )
2017
5
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. ( 28084339 )
2017
6
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. ( 27703092 )
2017
7
Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience. ( 28561906 )
2017
8
A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience. ( 27938440 )
2017
9
Sinonasal undifferentiated carcinoma originating from inverted papilloma: A case report. ( 29137081 )
2017
10
Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis. ( 29224819 )
2017
11
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma. ( 26752332 )
2016
12
Sinonasal Undifferentiated Carcinoma Presenting With Bilateral Compressive Optic Neuropathy. ( 27281738 )
2016
13
Pre-operative chemoradiation for sinonasal undifferentiated carcinoma of the anterior nasal cavity resected through a lateral nasal flap approach. ( 26954865 )
2016
14
Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival: A Population-Based Analysis. ( 26908559 )
2016
15
Role of (18) F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. ( 27481043 )
2016
16
Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. ( 27717204 )
2016
17
Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ( 26829682 )
2016
18
Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. ( 25844294 )
2015
19
Current management of sinonasal undifferentiated carcinoma. ( 26363162 )
2015
20
Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation. ( 25685767 )
2015
21
Sinonasal undifferentiated carcinoma as a third primary neoplasm: A case report and review of the literature. ( 25923276 )
2015
22
Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. ( 26407663 )
2015
23
Nodal Metastasis and Elective Nodal Level Treatment in Sinonasal Small Cell and Sinonasal Undifferentiated Carcinoma: A Surveillance, Epidemiology and End Results Analysis. ( 26559439 )
2015
24
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. ( 24421248 )
2014
25
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. ( 25017972 )
2014
26
Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. ( 25992139 )
2014
27
Molecular profiling of sinonasal undifferentiated carcinoma. ( 23633104 )
2014
28
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. ( 22992621 )
2013
29
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. ( 23663264 )
2013
30
Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma. ( 23553283 )
2013
31
Radiotherapy for sinonasal undifferentiated carcinoma. ( 24268566 )
2013
32
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. ( 23477516 )
2013
33
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. ( 23462605 )
2013
34
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. ( 22476411 )
2013
35
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. ( 23471826 )
2013
36
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. ( 23993024 )
2013
37
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. ( 23032744 )
2012
38
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. ( 22460731 )
2012
39
Sinonasal undifferentiated carcinoma presenting as recurrent fronto-ethmoidal pyomucocele. ( 23251060 )
2012
40
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). ( 21805120 )
2011
41
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. ( 21041001 )
2011
42
Prognostic factors for patients with sinonasal undifferentiated carcinoma. ( 21225771 )
2010
43
Sinonasal undifferentiated carcinoma metastatic to the skin. ( 19682175 )
2010
44
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. ( 20808529 )
2010
45
Primary ocular presentation of sinonasal undifferentiated carcinoma. ( 20090496 )
2010
46
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. ( 21059557 )
2010
47
Clinical manifestations of sinonasal undifferentiated carcinoma. ( 20013673 )
2009
48
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009
49
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. ( 19283847 )
2009
50
Liver transplantation for metastatic sinonasal undifferentiated carcinoma: a case report. ( 19100503 )
2008

Variations for Sinonasal Undifferentiated Carcinoma

Cosmic variations for Sinonasal Undifferentiated Carcinoma:

9
(show all 15)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6947540 U2AF1 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.587G>C p.R196T 21:43093238-43093238 21
2 COSM6904511 TSC1 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.2503-1G>T p.? 9:132900838-132900838 21
3 COSM6441198 RB1 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.940-1G>A p.? 13:48367493-48367493 21
4 COSM6947535 PTPRD upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.1141G>A p.A381T 9:8518250-8518250 21
5 COSM6977842 POLE upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.5329A>G p.S1777G 12:132641696-132641696 21
6 COSM521 KRAS upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.35G>A p.G12D 12:25245350-25245350 21
7 COSM1636997 IDH2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.515G>C p.R172T 15:90088606-90088606 21
8 COSM6947532 FOXL2 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.662C>T p.A221V 3:138946061-138946061 21
9 COSM6947539 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.587G>C p.R196T 21:43093238-43093238 21
10 COSM6947538 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.1141G>A p.A381T 9:8518250-8518250 21
11 COSM6947534 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.1141G>A p.A381T 9:8518250-8518250 21
12 COSM6947536 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.1111G>A p.A371T 9:8518250-8518250 21
13 COSM6947537 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.1132G>A p.A378T 9:8518250-8518250 21
14 COSM6947533 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.1141G>A p.A381T 9:8518250-8518250 21
15 COSM6977841 upper aerodigestive tract,sinonasal and nasal cavity,carcinoma,undifferentiated carcinoma c.5329A>G p.S1777G 12:132641696-132641696 21

Expression for Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for Sinonasal Undifferentiated Carcinoma

Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 MKI67 SYP
2
Show member pathways
10.97 ENO2 IDH2

GO Terms for Sinonasal Undifferentiated Carcinoma

Sources for Sinonasal Undifferentiated Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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