SNUC
MCID: SNN002
MIFTS: 28

Sinonasal Undifferentiated Carcinoma (SNUC)

Categories: Cancer diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

MalaCards integrated aliases for Sinonasal Undifferentiated Carcinoma:

Name: Sinonasal Undifferentiated Carcinoma 53 73
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 53
Snuc 53

Classifications:



External Ids:

UMLS 73 C1710096

Summaries for Sinonasal Undifferentiated Carcinoma

NIH Rare Diseases : 53 Sinonasal undifferentiated carcinoma (SNUC) is a type of cancer that develops in the sinuses of the head. SNUC occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass. The first symptoms of SNUC may include difficulty breathing though the nose or mild facial pain. As SNUC progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face. SNUC is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis). The cause of SNUC is still unknown. When possible, the treatment is the complete removal of the tumor, combined with radiation therapy and chemotherapy. In cases where the tumor can't be removed completely, the treatment is with radiation and chemotherapy. The risk of the tumor coming back (relapse) is high and the probability of cure is modest.

MalaCards based summary : Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to olfactory neuroblastoma and neuroblastoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Citrate cycle (TCA cycle). The drugs Docetaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung.

Wikipedia : 76 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Related Diseases for Sinonasal Undifferentiated Carcinoma

Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 olfactory neuroblastoma 30.5 ENO2 SYP
2 neuroblastoma 10.2
3 chondrosarcoma 10.2 ENO2 IDH2
4 hemangioma 10.1 ENO2 SYP
5 nervous system cancer 10.1 ENO2 SYP
6 carotid body cancer 10.1 ENO2 SYP
7 malignant sertoli cell tumor 10.1 ENO2 SYP
8 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
9 auditory system cancer 10.1 ENO2 SYP
10 gallbladder small cell carcinoma 10.1 ENO2 SYP
11 small cell carcinoma 10.1 ENO2 SYP
12 pancreatic somatostatinoma 10.1 ENO2 SYP
13 cutaneous ganglioneuroma 10.1 ENO2 SYP
14 ganglioneuroma 10.1 ENO2 SYP
15 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
16 small cell carcinoma of the bladder 10.1 ENO2 SYP
17 sensory organ benign neoplasm 10.1 ENO2 SYP
18 orbital cancer 10.1 ENO2 SYP
19 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP
20 large cell neuroendocrine carcinoma 10.1 ENO2 SYP
21 atypical follicular adenoma 10.1 ENO2 SYP
22 central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
23 optic nerve disease 10.1
24 papilloma 10.1
25 inverted papilloma 10.1
26 neuropathy 10.1
27 cerebellum cancer 10.1 ENO2 SYP
28 cerebral neuroblastoma 10.1 ENO2 SYP
29 cauda equina neoplasm 10.1 ENO2 SYP
30 endometrial small cell carcinoma 10.1 ENO2 SYP
31 extraosseous chondrosarcoma 10.1 ENO2 SYP
32 subependymal glioma 10.1 ENO2 SYP
33 malignant teratoma 10.1 ENO2 SYP
34 teratoma 10.1 ENO2 SYP
35 astroblastoma 10.1 ENO2 SYP
36 cerebral ventricle cancer 10.1 ENO2 SYP
37 olfactory nerve neoplasm 10.1 ENO2 SYP
38 pineal gland cancer 10.1 ENO2 SYP
39 autonomic nervous system benign neoplasm 10.1 ENO2 SYP
40 nervous system benign neoplasm 10.1 ENO2 SYP
41 benign ependymoma 10.1 ENO2 SYP
42 nodular ganglioneuroblastoma 10.1 ENO2 SYP
43 ganglioneuroblastoma 10.1 ENO2 SYP
44 pineocytoma 10.1 ENO2 SYP
45 rhabdoid cancer 10.1 ENO2 SYP
46 angiomyoma 10.1 ENO2 SYP
47 cervical clear cell adenocarcinoma 10.1 ENO2 SYP
48 gastric small cell carcinoma 10.1 ENO2 SYP
49 subependymoma 10.1 ENO2 SYP
50 carcinoid tumors, intestinal 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to Sinonasal Undifferentiated Carcinoma

Symptoms & Phenotypes for Sinonasal Undifferentiated Carcinoma

Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

Drugs for Sinonasal Undifferentiated Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
7
leucovorin Approved Phase 2 58-05-9 6006 143
8
Ifosfamide Approved Phase 2 3778-73-2 3690
9
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
10
Doxil Approved June 1999 Phase 2 31703
11 Immunologic Factors Phase 2
12 Antimetabolites, Antineoplastic Phase 2
13 Immunosuppressive Agents Phase 2
14 Antimetabolites Phase 2
15 Antimitotic Agents Phase 2
16
Isophosphamide mustard Phase 2 0
17 Topoisomerase Inhibitors Phase 2
18 Antineoplastic Agents, Phytogenic Phase 2
19 Antibiotics, Antitubercular Phase 2
20 Pharmaceutical Solutions Phase 2
21 Antineoplastic Agents, Alkylating Phase 2
22 Alkylating Agents Phase 2
23 Anti-Bacterial Agents Phase 2
24 Etoposide phosphate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Docetaxel, Cisplatin and Fluorouracil in Treating Participants With Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer Recruiting NCT00707473 Phase 2 Carboplatin;Cisplatin;Docetaxel;Fluorouracil
2 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients Active, not recruiting NCT02099188 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
3 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Operable Patients Active, not recruiting NCT02099175 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
4 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Recruiting NCT01586767 Not Applicable

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

Anatomical Context for Sinonasal Undifferentiated Carcinoma

MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

41
Brain, Liver, Lung, Kidney, Bone, Thymus, Pineal

Publications for Sinonasal Undifferentiated Carcinoma

Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50) (show all 96)
# Title Authors Year
1
A Case of Sinonasal Undifferentiated Carcinoma with Brain Metastases. ( 29755916 )
2018
2
Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study. ( 29935059 )
2018
3
The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma. ( 30206411 )
2018
4
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study. ( 30373873 )
2018
5
Sinonasal undifferentiated carcinoma with metastasis to the extradural spine. ( 30450992 )
2018
6
Oncologic management of sinonasal undifferentiated carcinoma. ( 30507692 )
2018
7
Long-term follow-up of a patient with malignant transformation of inverted papilloma into sinonasal undifferentiated carcinoma. ( 29070275 )
2017
8
Spinal Cord Compression Secondary to Metastatic Sinonasal Undifferentiated Carcinoma. ( 28868018 )
2017
9
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. ( 28084339 )
2017
10
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. ( 27703092 )
2017
11
Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience. ( 28561906 )
2017
12
A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience. ( 27938440 )
2017
13
Sinonasal undifferentiated carcinoma originating from inverted papilloma: A case report. ( 29137081 )
2017
14
Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis. ( 29224819 )
2017
15
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma. ( 26752332 )
2016
16
Sinonasal Undifferentiated Carcinoma Presenting With Bilateral Compressive Optic Neuropathy. ( 27281738 )
2016
17
Pre-operative chemoradiation for sinonasal undifferentiated carcinoma of the anterior nasal cavity resected through a lateral nasal flap approach. ( 26954865 )
2016
18
Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival: A Population-Based Analysis. ( 26908559 )
2016
19
Role of (18) F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. ( 27481043 )
2016
20
Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. ( 27717204 )
2016
21
Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ( 26829682 )
2016
22
Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. ( 25844294 )
2015
23
Current management of sinonasal undifferentiated carcinoma. ( 26363162 )
2015
24
Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation. ( 25685767 )
2015
25
Sinonasal undifferentiated carcinoma as a third primary neoplasm: A case report and review of the literature. ( 25923276 )
2015
26
Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. ( 26407663 )
2015
27
Nodal Metastasis and Elective Nodal Level Treatment in Sinonasal Small Cell and Sinonasal Undifferentiated Carcinoma: A Surveillance, Epidemiology and End Results Analysis. ( 26559439 )
2015
28
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. ( 24421248 )
2014
29
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. ( 25017972 )
2014
30
Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. ( 25992139 )
2014
31
Molecular profiling of sinonasal undifferentiated carcinoma. ( 23633104 )
2014
32
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. ( 22992621 )
2013
33
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. ( 23663264 )
2013
34
Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma. ( 23553283 )
2013
35
Radiotherapy for sinonasal undifferentiated carcinoma. ( 24268566 )
2013
36
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. ( 23477516 )
2013
37
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. ( 23462605 )
2013
38
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. ( 22476411 )
2013
39
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. ( 23471826 )
2013
40
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. ( 23993024 )
2013
41
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. ( 23032744 )
2012
42
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. ( 22460731 )
2012
43
Sinonasal undifferentiated carcinoma presenting as recurrent fronto-ethmoidal pyomucocele. ( 23251060 )
2012
44
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). ( 21805120 )
2011
45
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. ( 21041001 )
2011
46
Prognostic factors for patients with sinonasal undifferentiated carcinoma. ( 21225771 )
2010
47
Sinonasal undifferentiated carcinoma metastatic to the skin. ( 19682175 )
2010
48
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. ( 20808529 )
2010
49
Primary ocular presentation of sinonasal undifferentiated carcinoma. ( 20090496 )
2010
50
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. ( 21059557 )
2010

Variations for Sinonasal Undifferentiated Carcinoma

Expression for Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for Sinonasal Undifferentiated Carcinoma

Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 MKI67 SYP
2
Show member pathways
10.97 ENO2 IDH2

GO Terms for Sinonasal Undifferentiated Carcinoma

Sources for Sinonasal Undifferentiated Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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