SNUC
MCID: SNN002
MIFTS: 30

Sinonasal Undifferentiated Carcinoma (SNUC)

Categories: Cancer diseases, Rare diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

MalaCards integrated aliases for Sinonasal Undifferentiated Carcinoma:

Name: Sinonasal Undifferentiated Carcinoma 12 20 17 70
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 20
Snuc 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0080799
NCIt 50 C54294
UMLS 70 C1710096

Summaries for Sinonasal Undifferentiated Carcinoma

GARD : 20 Sinonasal undifferentiated carcinoma (SNUC) is a type of cancer that develops in the sinuses of the head. SNUC occurs when cells from the layer of tissue that lines the sinuses (called the epithelium ) rapidly increase in number, forming a mass. The first symptoms of SNUC may include difficulty breathing though the nose or mild facial pain. As SNUC progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face. SNUC is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body ( metastasis ). The cause of SNUC is still unknown. When possible, the treatment is the complete removal of the tumor, combined with radiation therapy and chemotherapy. In cases where the tumor can't be removed completely, the treatment is with radiation and chemotherapy. The risk of the tumor coming back (relapse) is high and the probability of cure is modest.

MalaCards based summary : Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to olfactory neuroblastoma and large cell neuroendocrine carcinoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is CEACAM3 (CEA Cell Adhesion Molecule 3), and among its related pathways/superpathways is Neuroscience. The drugs Cisplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and spinal cord.

Disease Ontology : 12 A nasal cavity carcinoma that arises from the sinonasal tract and that is characterized by the presence of small to medium size malignant cells.

Wikipedia : 73 Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive type of cancer that arises from... more...

Related Diseases for Sinonasal Undifferentiated Carcinoma

Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 olfactory neuroblastoma 31.1 SYP ENO2
2 large cell neuroendocrine carcinoma 30.1 SYP ENO2
3 neuroendocrine carcinoma 30.1 SYP MUC1 ENO2
4 rhabdoid cancer 29.9 SYP MUC1
5 neurilemmoma 29.8 MUC1 ENO2
6 neuroendocrine tumor 29.7 SYP MKI67 ENO2
7 lymphoepithelioma-like carcinoma 29.7 MUC1 ENO2 CEACAM3
8 small cell carcinoma 29.6 SYP MUC1 ENO2
9 chondrosarcoma 29.6 MUC1 IDH2 ENO2
10 cholangiocarcinoma 29.5 MUC1 IDH2 CEACAM3
11 intrahepatic cholangiocarcinoma 29.4 MUC1 IDH2
12 meningioma, familial 29.3 SYP MUC1 MKI67
13 neuroblastoma 10.4
14 rare tumor 10.4
15 nasopharyngeal carcinoma 10.2
16 squamous cell papilloma 10.2
17 optic nerve disease 10.2
18 papilloma 10.2
19 neuropathy 10.2
20 exophthalmos 10.2
21 adenocarcinoma 10.2
22 inverted papilloma 10.2
23 malignant melanocytic neoplasm of the peripheral nerve sheath 10.1 SYP ENO2
24 anal neuroendocrine tumor 10.1 SYP ENO2
25 optic nerve astrocytoma 10.1 SYP ENO2
26 cerebral neuroblastoma 10.1 SYP ENO2
27 neuronal intestinal dysplasia, type b 10.1 SYP ENO2
28 lung meningioma 10.1 SYP ENO2
29 auditory system benign neoplasm 10.1 SYP ENO2
30 auditory system cancer 10.1 SYP ENO2
31 cloacogenic carcinoma 10.1 SYP ENO2
32 pineal region teratoma 10.1 SYP ENO2
33 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 SYP ENO2
34 cauda equina neoplasm 10.1 SYP ENO2
35 intracranial primitive neuroectodermal tumor 10.1 SYP ENO2
36 nodular prostate 10.1 SYP ENO2
37 ampulla of vater benign neoplasm 10.1 SYP ENO2
38 appendix carcinoid tumor 10.1 SYP ENO2
39 carotid body cancer 10.1 SYP ENO2
40 gallbladder small cell carcinoma 10.1 SYP ENO2
41 ureter small cell carcinoma 10.1 SYP ENO2
42 cerebellar liponeurocytoma 10.1 SYP ENO2
43 cerebellopontine angle primitive neuroectodermal tumor 10.1 SYP ENO2
44 urinary bladder small cell neuroendocrine carcinoma 10.1 SYP ENO2
45 gastric small cell carcinoma 10.1 SYP ENO2
46 extracranial neuroblastoma 10.1 SYP ENO2
47 jejunal neoplasm 10.1 SYP ENO2
48 frontal lobe neoplasm 10.1 SYP ENO2
49 sensory organ benign neoplasm 10.1 SYP ENO2
50 cervical neuroblastoma 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to Sinonasal Undifferentiated Carcinoma

Symptoms & Phenotypes for Sinonasal Undifferentiated Carcinoma

Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

Drugs for Sinonasal Undifferentiated Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Etoposide Approved Phase 2 33419-42-0 36462
3 Etoposide phosphate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II, Single-Arm Trial Assessing Local Control of Near Total Endoscopic Resection Followed by Concurrent Chemotherapy and Proton Radiation in the Treatment of Unresectable Sinonasal Tumors Active, not recruiting NCT03274414 Phase 2 Cisplatin;cisplatin and etoposide

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

Anatomical Context for Sinonasal Undifferentiated Carcinoma

MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

40
Pituitary, Brain, Spinal Cord, Small Intestine, Kidney, Thyroid, Skin

Publications for Sinonasal Undifferentiated Carcinoma

Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50) (show all 241)
# Title Authors PMID Year
1
Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. 61 20
27717204 2017
2
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. 61 20
27703092 2017
3
Outcomes of Primary Versus Salvage Surgery for Sinonasal Malignancies: A Population-Based Analysis. 61
32706415 2021
4
Targeting MET Amplification with Crizotinib in a Case of Sinonasal Undifferentiated Carcinoma. 61
33538211 2021
5
SWI/SNF-deficient head and neck neoplasms: An overview. 61
33663878 2021
6
Management of a Unique Sinonasal Undifferentiated Carcinoma Subtype in the Era of SARS-CoV-2. 61
33017834 2021
7
Loss of SMARCB1 Expression Confers Poor Prognosis to Sinonasal Undifferentiated Carcinoma. 61
33381364 2020
8
High-grade sinonasal carcinomas and surveillance of differential expression in immune related transcriptome. 61
32927372 2020
9
Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase. 61
32424573 2020
10
Design, development, and evaluation of the efficacy of a nucleic acid-free version of a bacterial ghost candidate vaccine against avian pathogenic E. coli (APEC) O78:K80 serotype. 61
33298146 2020
11
The Novel Use of Atomized Intravenous Ketamine Solution for the Topical Treatment of Intranasal Mucositis Pain: A Case Report. 61
33147088 2020
12
SMARCB1/INI1 Deficient Sino-Nasal Carcinoma: Extending the Histomorphological Features. 61
33141418 2020
13
A rare presentation of Sinonasal Undifferentiated Carcinoma with brain metastasis and para-aortic mass. 61
33344330 2020
14
Sinonasal undifferentiated carcinoma: Institutional trend toward induction chemotherapy followed by definitive chemoradiation. 61
32681692 2020
15
Clinical Implication of Diagnostic and Histopathologic Discrepancies in Sinonasal Malignancies. 61
32946597 2020
16
Clinical management of emerging sinonasal malignancies. 61
32212360 2020
17
Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside. 61
32725435 2020
18
A subset of sinonasal undifferentiated carcinoma is associated with transcriptionally active high-risk human papillomavirus by in situ hybridization: a clinical and pathologic analysis. 61
32416210 2020
19
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. 61
31468350 2020
20
Impact of induction chemotherapy and socioeconomics on sinonasal undifferentiated carcinoma survival. 61
32104985 2020
21
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis. 61
31922316 2020
22
[Diagnosis, prognosis and treatment of sinonasal carcinomas (excluding melanomas, sarcomas and lymphomas)]. 61
32305127 2020
23
SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies. 61
31934917 2020
24
SMARCB1-Deficient Sinonasal Carcinoma: Systematic Review and Case Report. 61
32001406 2020
25
Sinonasal Undifferentiated Carcinoma (SNUC): From an Entity to Morphologic Pattern and Back Again-A Historical Perspective. 61
31876536 2020
26
IDH2 Mutation Analysis in Undifferentiated and Poorly Differentiated Sinonasal Carcinomas for Diagnosis and Clinical Management. 61
31876581 2020
27
Positron emission computed tomography and magnetic resonance imaging features of sinonasal small round blue cell tumors. 61
31460836 2020
28
The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review. 61
32850452 2020
29
The Evolving Role of Systemic Therapy in the Primary Treatment of Sinonasal Cancer. 61
32731241 2020
30
[Treatment of primary craniofacial (sinonasal) malignant tumors affecting the anterior and middle skull base]. 61
32207749 2020
31
Neuroendocrine Carcinoma and Sinonasal Undifferentiated Carcinoma. 61
32731236 2020
32
High-Grade Sinonasal Carcinoma: Classification Through Molecular Profiling. 61
30779592 2019
33
Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers. 61
31727977 2019
34
Sinonasal Undifferentiated Carcinoma in a Patient Previously Treated for an Intestinal-Type Adenocarcinoma: Metachronous Neoplasms or Recurrence of a Different Tumor Type? 61
31763244 2019
35
DNA methylation-based classification of sinonasal undifferentiated carcinoma. 61
31186531 2019
36
Identification of markers predictive for response to induction chemotherapy in patients with sinonasal undifferentiated carcinoma. 61
31421472 2019
37
Identification of novel diagnostic markers for sinonasal undifferentiated carcinoma. 61
30932264 2019
38
Septal Flip Flap for Anterior Skull Base Reconstruction After Endoscopic Transnasal Craniectomy: Long-Term Outcomes. 61
31042605 2019
39
Sinonasal undifferentiated carcinoma: clinicopathological spectrums and diagnosis reappraisal. 61
31054892 2019
40
Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report. 61
31186808 2019
41
Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms. 61
30769222 2019
42
Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature. 61
30779722 2019
43
Induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report. 61
30968042 2019
44
A functional gene expression analysis in epithelial sinonasal cancer: Biology and clinical relevance behind three histological subtypes. 61
30846184 2019
45
Sinosanal undifferentiated carcinoma with liver metastasis: surgical management. 61
30800274 2019
46
Sinonasal Undifferentiated Carcinoma. 61
30806835 2019
47
Sinonasal Undifferentiated Carcinoma: A 15-Year Single Institution Experience. 61
30733906 2019
48
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma. 61
30615549 2019
49
Oncologic management of sinonasal undifferentiated carcinoma. 61
30507692 2019
50
The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma. 61
30206411 2019

Variations for Sinonasal Undifferentiated Carcinoma

Expression for Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for Sinonasal Undifferentiated Carcinoma

Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 SYP MKI67 ENO2

GO Terms for Sinonasal Undifferentiated Carcinoma

Sources for Sinonasal Undifferentiated Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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