MCID: SNS014
MIFTS: 64

Sinusitis

Categories: Oral diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Sinusitis

MalaCards integrated aliases for Sinusitis:

Name: Sinusitis 39 30 56 44 17 74 64

Classifications:



External Ids:

UMLS 74 C0037199

Summaries for Sinusitis

MedlinePlus : 44 Sinusitis means your sinuses are inflamed. The cause can be an infection or another problem. Your sinuses are hollow air spaces within the bones surrounding the nose. They produce mucus, which drains into the nose. If your nose is swollen, this can block the sinuses and cause pain. There are several types of sinusitis, including Acute, which lasts up to 4 weeks Subacute, which lasts 4 to 12 weeks Chronic, which lasts more than 12 weeks and can continue for months or even years Recurrent, with several attacks within a year Acute sinusitis often starts as a cold, which then turns into a bacterial infection. Allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. Symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. Your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. You may also need imaging tests. Treatments include antibiotics, decongestants, and pain relievers. Using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Sinusitis is related to common cold and cystic fibrosis, and has symptoms including tremor, fever and angina pectoris. An important gene associated with Sinusitis is CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Augmentin and Avelox I.V. have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are digestive/alimentary and immune system

PubMed Health : 64 About sinusitis: Sinusitis is an inflammation of the paranasal sinuses. The full medical term for sinusitis is "rhinosinusitis" ("rhino-" meaning "nose"), because it affects the mucous membranes lining both the nose and the sinuses.The paranasal sinuses are part of the upper airways, and are connected to the nasal cavity. They are made up of several cavities in the skull found from the forehead down to the teeth of the upper jaw. Depending on where they are, these cavities are known as the frontal sinuses, the sphenoid sinus, the ethmoid cells and the maxillary sinuses. The paranasal sinuses are lined with mucous membranes that have tiny hairs (ciliated epithelium). These mucous membranes produce a secretion that runs down through the nose and throat.

Wikipedia : 77 Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the mucous membrane... more...

Related Diseases for Sinusitis

Diseases in the Sinusitis family:

Chronic Frontal Sinusitis Frontal Sinusitis
Acute Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 614)
# Related Disease Score Top Affiliating Genes
1 common cold 32.7 CXCL8 IL5 RNASE3
2 cystic fibrosis 31.4 CFTR CXCL8 DEFB4A RNASE3
3 cellulitis 30.7 IL5 RNASE3
4 respiratory system disease 30.6 CFTR CXCL8 CYSLTR1 IL5 RNASE3
5 allergic bronchopulmonary aspergillosis 30.6 CFTR IL5
6 allergic rhinitis 30.2 CXCL8 IL4R IL5 RNASE3
7 bronchitis 30.0 CFTR CXCL8 IL5 RNASE3
8 rhinitis 30.0 CXCL8 CYSLTR1 IL4R IL5 RNASE3
9 tonsillitis 29.9 CXCL8 DEFB4A
10 conjunctivitis 29.7 CXCL8 IL5 RNASE3
11 pollen allergy 29.6 IL4R IL5 RNASE3
12 milk allergy 29.6 IL5 RNASE3
13 ige responsiveness, atopic 29.6 IL4R IL5 RNASE3
14 intrinsic asthma 29.6 IL5 RNASE3
15 status asthmaticus 29.6 CXCL8 IL5 RNASE3
16 churg-strauss syndrome 29.5 IL5 RNASE3
17 allergic contact dermatitis 29.5 CXCL8 IL5
18 respiratory allergy 29.5 IL4R IL5 RNASE3
19 keratoconjunctivitis 29.4 CXCL8 IL5 RNASE3
20 pulmonary disease, chronic obstructive 29.4 CFTR CXCL8 RNASE3
21 allergic asthma 29.3 IL4R IL5 RNASE3
22 food allergy 29.3 IL5 RNASE3
23 asthma 29.2 CFTR CXCL8 CYSLTR1 IL4R IL5 LTC4S
24 lung disease 29.1 CFTR CXCL8 IL5 RNASE3
25 gingivitis 28.9 CXCL8 DEFB4A
26 maxillary sinusitis 12.6
27 sphenoid sinusitis 12.6
28 ethmoid sinusitis 12.6
29 frontal sinusitis 12.6
30 chronic maxillary sinusitis 12.5
31 acute maxillary sinusitis 12.5
32 acute frontal sinusitis 12.5
33 chronic frontal sinusitis 12.5
34 chronic sphenoidal sinusitis 12.5
35 acute sphenoidal sinusitis 12.4
36 rokitansky-aschoff sinuses of the gallbladder 12.4
37 microcornea, glaucoma, and absent frontal sinuses 12.1
38 chronic ethmoiditis 12.1
39 acute ethmoiditis 11.9
40 kartagener syndrome 11.9
41 sinonasal undifferentiated carcinoma 11.8
42 young syndrome 11.7
43 squamous cell carcinoma, head and neck 11.6
44 panbronchiolitis, diffuse 11.5
45 inverted papilloma 11.5
46 primary ciliary dyskinesia 11.4
47 granulomatosis with polyangiitis 11.4
48 mucormycosis 11.4
49 yellow nail syndrome 11.3
50 phaeohyphomycosis 11.3

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to Sinusitis

Symptoms & Phenotypes for Sinusitis

UMLS symptoms related to Sinusitis:


tremor, fever, angina pectoris, pruritus, headache, tinnitus, snoring, sore throat, coughing, vertigo/dizziness, equilibration disorder, halitosis, sinus congestion

MGI Mouse Phenotypes related to Sinusitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 BTK CFTR IL12RB2 IL4R IL5
2 immune system MP:0005387 9.5 BTK CFTR CYSLTR1 IL12RB2 IL4R IL5
3 respiratory system MP:0005388 9.02 CFTR CYSLTR1 IL4R IL5 LTC4S

Drugs & Therapeutics for Sinusitis

PubMedHealth treatment related to Sinusitis: 64

Steroidal or decongestant nasal sprays may relieve discomfort in patients with sinusitis. Nasal irrigation or inhalation may also help, and antibiotics may be an option in some cases.In case of chronic inflammation, one common treatment is surgery to expand narrowed paranasal sinus passageways. This is an option if steroid sprays and other treatments do not provide enough relief.

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Augmentin 19 AMOXICILLIN; CLAVULANATE POTASSIUM SmithKline Beecham February 1996
2
Avelox I.V. 19 MOXIFLOXACIN HYDROCHLORIDE Bayer November 2001
3
Biaxin XL 19 CLARITHROMYCIN Abbott Laboratories March 2000
4
Cipro 19 CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE Bayer June 1997
5
Tequin 19 Bristol-Myers Squibb December, 1999

Drugs for Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 368)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 26787-78-0 33613
3 Strawberry Approved Phase 4,Phase 3
4
mometasone furoate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83919-23-7
5
Montelukast Approved Phase 4 158966-92-8 5281040
6
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
7
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
8
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
9
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
10
Cefditoren Approved, Investigational Phase 4 117467-28-4, 104145-95-1 9571074 9870843
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
12
Pseudoephedrine Approved Phase 4,Phase 2,Not Applicable 90-82-4 7028
13
Ephedrine Approved Phase 4,Phase 2,Not Applicable 299-42-3 9294
14
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51333-22-3 63006 5281004
15
Racepinephrine Approved Phase 4,Phase 3,Not Applicable 329-65-7 838
16
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 51-43-4 5816
17
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
18
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
19
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
20
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
21
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
22
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2 242138-07-4
23
Ofloxacin Approved Phase 4,Phase 3,Phase 1,Phase 2 82419-36-1 4583
24
Cefdinir Approved Phase 4 91832-40-5 6915944
25
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 100986-85-4 149096
26
Telithromycin Approved Phase 4,Phase 3 191114-48-4 70789201 5462516
27
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
28
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
29
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
30
Dextromethorphan Approved Phase 4 125-71-3 5362449 5360696
31
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 103-90-2 1983
32
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 124-94-7 31307
33
Thrombin Approved, Investigational Phase 4
34
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
35
Dopamine Approved Phase 4,Phase 3,Phase 2 62-31-7, 51-61-6 681
36
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
37
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 113775-47-6 68602 5311068
38
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
39
Histamine Approved, Investigational Phase 4,Not Applicable 51-45-6 774
40
Almotriptan Approved, Investigational Phase 4 181183-52-8, 154323-57-6 123606
41
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
42
Clarithromycin Approved Phase 4,Phase 3,Not Applicable 81103-11-9 84029
43
Etanercept Approved, Investigational Phase 4 185243-69-0
44
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
45
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3 2921-57-5
46
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3 302-25-0
47
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
48
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
49
Oseltamivir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 204255-11-8, 196618-13-0 65028
50
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Early Phase 1 15687-27-1 3672

Interventional clinical trials:

(show top 50) (show all 434)
# Name Status NCT ID Phase Drugs
1 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
3 Remifentanil and Controlled Hypotension for Functional Endoscopic Sinus Surgery: Comparison With Tramadol and Metoprolol Unknown status NCT02484859 Phase 4 Remifentanil;Tramadol;Metoprolol
4 Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis Unknown status NCT01553006 Phase 4 cefditoren pivoxil
5 Sinuclean's Treatment Of Sinusitis' Symptoms Completed NCT00747747 Phase 4
6 Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis Completed NCT02296814 Phase 4 Sinusitis Hevert SL Tablet;Placebo for Sinusitis Hevert SL Tablet
7 Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate Completed NCT02340000 Phase 4 standard dose amoxicillin/clavulanate;high dose amoxicillin/clavulanate
8 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
9 Xolair in Patients With Chronic Sinusitis Completed NCT00117611 Phase 4 Anti-IgE antibody omalizumab or placebo
10 Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis Completed NCT00645073 Phase 4 cefdinir (Omnicef);levofloxacin
11 Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life Completed NCT00147914 Phase 4 Cefdinir (drug);amoxicillin/clavulanate
12 CHOOSE : Telithromycin, Acute Bacterial Sinusitis Completed NCT00174694 Phase 4 Telithromycin
13 Zmax Compared to Augmentin in Sinusitis Completed NCT00367120 Phase 4 Azithromycin Extended Release;Amoxicillin/Clavulanate
14 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed NCT01825408 Phase 4 Doxycycline;Azithromycin;Augmentin
15 Treatment of Acute Sinusitis Completed NCT00377403 Phase 4 Acetaminophen;Amoxicillin;Dextromethorphan hydrobromide with guaifenesin;Guaifenesin;Pseudoephedrine Sustained Action;Saline spray (0.65%)
16 Saline Irrigation After Surgery in Patients With Chronic Sinusitis Completed NCT01575223 Phase 4
17 Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial Completed NCT01919411 Phase 4 Amoxicillin-Potassium Clavulanate;Placebo
18 The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device Completed NCT02079792 Phase 4
19 Medicated Punctured-Glove-Finger Spacer Study Completed NCT01420471 Phase 4 Triamcinolone
20 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
21 Hemostatic Matrix in Endoscopic Sinus Surgery Completed NCT00242437 Phase 4
22 Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery Completed NCT01706952 Phase 4 Cocaine;Adrenaline
23 Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery Completed NCT01569048 Phase 4 Propofol and dexmedetomidine;propofol and remifentanil
24 The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant Completed NCT02668302 Phase 4
25 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
26 Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers Completed NCT00208065 Phase 4 almotriptan or pseudoephedrine
27 The Effect of Packing in Post Operative Management of FESS Completed NCT00793117 Phase 4
28 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis Completed NCT00396162 Phase 4 probiotic containing L.rhamnosus R0011 strain
29 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
30 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
31 Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders Completed NCT00132418 Phase 4 Enbrel;Placebo
32 Telithromycin in Respiratory Tract Infections Completed NCT00261105 Phase 4 telithromycin
33 Proteomic Profiling for Influenza Completed NCT00133588 Phase 4
34 Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy Completed NCT02307825 Phase 4 Azithromycin;Placebo
35 Systemic Methylprednisolone in Chronic Rhinosinusitis Completed NCT01205984 Phase 4 methylprednisolone
36 Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Completed NCT02119273 Phase 4 Prednisone;Placebo
37 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis Completed NCT03086070 Phase 4 Omeprazole 20mg;Placebo oral capsule
38 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
39 Clinical Trial of Clinical Efficiency and Safety of Ergoferon in Treatment of Influenza Completed NCT01804946 Phase 4 Ergoferon;Oseltamivir
40 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix TM) Administered in Healthy Adolescents Completed NCT00534638 Phase 4
41 The Benefit and Harm of Fever Suppression by Antipyretics in Influenza Completed NCT01891084 Phase 4 Paracetamol;Placebo;Backup NSAID ibuprofen
42 Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate Recruiting NCT03431337 Phase 4 Amoxicillin 875 mg
43 The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis Recruiting NCT02582099 Phase 4 Gentamicin nasal irrigation;Normal saline nasal irrigation
44 Response of the Airway in Sinusitis and Asthma Recruiting NCT03011632 Phase 4 Mometasone Nasal;placebo mometasone
45 Use of Perioperative Antibiotics in Endoscopic Sinus Surgery Recruiting NCT03369717 Phase 4 Amoxi Clavulanate
46 Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Recruiting NCT03014687 Phase 4 Placebo;Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
47 Group A Pharyngitis in Children: The GASPARD Study Recruiting NCT03264911 Phase 4 Amoxicillin or Placebo
48 Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study Active, not recruiting NCT00841802 Phase 4 Prednisone
49 The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp Not yet recruiting NCT03809312 Phase 4 Amoxicillin / Clavulanic acid 875mg / 125mg;Placebos
50 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4

Search NIH Clinical Center for Sinusitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Sinusitis

Genetic tests related to Sinusitis:

# Genetic test Affiliating Genes
1 Sinusitis 30

Anatomical Context for Sinusitis

MalaCards organs/tissues related to Sinusitis:

42
Bone, Testes, Skin, Brain, Tonsil, Pituitary, Bone Marrow

Publications for Sinusitis

Articles related to Sinusitis:

(show top 50) (show all 3585)
# Title Authors Year
1
Brooke-Spiegler syndrome with chronic obstructive pulmonary disease and chronic sinusitis. ( 30628115 )
2019
2
Acquired Pediatric Brown Syndrome Secondary to Sinusitis. ( 30907972 )
2019
3
A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis. ( 30692835 )
2019
4
Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis. ( 30700458 )
2019
5
Deep Learning in Diagnosis of Maxillary Sinusitis Using Conventional Radiography. ( 30067607 )
2019
6
Nocardial clival osteomyelitis secondary to sphenoid sinusitis: an atypical skull base infection. ( 30607637 )
2019
7
Antibiotic Recommendations for Acute Otitis Media and Acute Bacterial Sinusitis. ( 30640191 )
2019
8
New tools for preoperative diagnosis of allergic fungal sinusitis? A prospective study about 71 patients. ( 30354031 )
2019
9
Sinusitis Update. ( 30454779 )
2019
10
The role of surfactant protein-A in sinusitis. ( 30507715 )
2019
11
Formation of papillary mucosa folds and enhancement of epithelial barrier in odontogenic sinusitis. ( 30620087 )
2019
12
Pediatric trochleitis associated with paranasal sinusitis: a case report. ( 30642284 )
2019
13
Clinical and Virological Characteristics of Acute Sinusitis in Children. ( 30649261 )
2019
14
Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis. ( 30651053 )
2019
15
Use of Dipstick Assay and Rapid PCR-DNA Analysis of Nasal Secretions for Diagnosis of Bacterial Sinusitis in Children With Chronic Cough. ( 30671281 )
2019
16
Chronic Sinusitis: Saline Irrigation Helps Somewhat; Steroid Does Not Add More Benefit. ( 30702248 )
2019
17
Acute sinusitis complicated with Pott puffy tumour. ( 30745402 )
2019
18
Factors of success of low-dose macrolides in chronic sinusitis: Systematic review and meta-analysis. ( 30746710 )
2019
19
Basilar occlusion and rupture secondary to rare fungal sinusitis: A case report. ( 30772526 )
2019
20
Results of endoscopic nasal surgery in the treatment of invasive fungal sinusitis in children with cancer and immunosuppression. ( 30773220 )
2019
21
What Affects Postoperative Sinusitis and Implant Failure after Dental Implant: A Meta-analysis. ( 30776960 )
2019
22
Successful Treatment of Scedosporium Sinusitis in Two Lung Transplant Recipients: Review of the Literature and Recommendations for Management. ( 30792939 )
2019
23
Budget Impact of a Steroid-Eluting Sinus Implant Versus Sinus Surgery for Adult Chronic Sinusitis Patients with Nasal Polyps. ( 30843454 )
2019
24
Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence. ( 30851064 )
2019
25
The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis. ( 30859336 )
2019
26
Bilateral orbital apex syndrome secondary to sinusitis. ( 30859705 )
2019
27
Nine Cases of Methanogenic Archaea in Refractory Sinusitis, an Emerging Clinical Entity. ( 30886840 )
2019
28
Invasive Fungal Sinusitis: Risk Factors for Visual Acuity Outcomes and Mortality. ( 30893189 )
2019
29
No Differences in Nasal Tissue Inflammatory Cells and Adhesion Molecules (iCAM-1 and vCAM-1) Based on the Comparison of EGPA With Eosinophilic Chronic Sinusitis With Polyposis. ( 30905163 )
2019
30
Intracranial subdural abscess with polymicrobial infections due to frontal sinusitis in an adolescent: life-threatening complication of a common disease. ( 29531731 )
2018
31
Differences in expression of YKL-40 and TLR4 in nasal sinus mucosa of chronic sinusitis patients with and without nasal polyps. ( 29921378 )
2018
32
Orbital granulomatosis with polyangiitis masquerading as invasive fungal sinusitis. ( 29303390 )
2018
33
Orbital cellulitis secondary to a fungal sinusitis caused by Scopulariopsis: The first case in Tunisia. ( 29709267 )
2018
34
Clinical implications of taste thresholds in patients with odontogenic maxillary sinusitis. ( 29174862 )
2018
35
Gene and protein expression of <i>CXCR4</i> in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations. ( 29497453 )
2018
36
Intracranial complications of acute sinusitis in children: The role of endoscopic sinus surgery. ( 29859578 )
2018
37
Rapidly Developing Subdural Empyema in an Adult with Sinusitis: A Neurosurgical Threat Alert. ( 29682060 )
2018
38
Carotid dissection mimicking sinusitis. ( 29369929 )
2018
39
A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps. ( 29350840 )
2018
40
Ophthalmic Manifestations of Allergic Fungal Sinusitis. ( 29384825 )
2018
41
ACTUAL ISSUES OF ODONTOGENIC MAXILLARY SINUSITIS (REVIEW). ( 29697380 )
2018
42
Early life risk factors for chronic sinusitis: a longitudinal birth cohort study. ( 29355680 )
2018
43
Efficacy of sinus ultrasound in diagnosis of acute and subacute maxillary sinusitis. ( 29779998 )
2018
44
Inflammatory immune response in rabbits with Staphylococcus aureus biofilm-associated sinusitis. ( 29979838 )
2018
45
Comparison between the Effects of Oral and Intramuscular Administration of Shin'iseihaito (Xinyiqingfeitang) in a <i>Streptococcus pyogenes</i>-Induced Murine Sinusitis Model. ( 29853978 )
2018
46
Isolated abducens palsy due to acute sphenoid sinusitis. ( 29730382 )
2018
47
Appropriateness of antibiotic prescriptions for acute sinusitis and pharyngitis in an integrated healthcare system. ( 29807555 )
2018
48
A multi-institutional review of outcomes in biopsy-proven acute invasive fungal sinusitis. ( 29979836 )
2018
49
Is phage therapy suitable for treating chronic sinusitis Staphylococcus aureus infection? ( 29792517 )
2018
50
Brain abscess in a patient with chronic sinusitis. ( 29321201 )
2018

Variations for Sinusitis

Expression for Sinusitis

LifeMap Discovery
Genes differentially expressed in tissues of Sinusitis patients vs. healthy controls: 35 (show all 38)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FDCSP follicular dendritic cell secreted protein Nose + 5.87 0.000
2 MUC7 mucin 7, secreted Nose + 5.43 0.001
3 PIP prolactin-induced protein Nose + 5.28 0.000
4 STATH statherin Nose + 5.17 0.000
5 KRT14 keratin 14, type I Nose + 4.90 0.000
6 CRISP3 cysteine-rich secretory protein 3 Nose + 4.46 0.007
7 C6orf58 chromosome 6 open reading frame 58 Nose + 4.30 0.002
8 BPIFB2 BPI fold containing family B, member 2 Nose + 4.26 0.002
9 IGHM immunoglobulin heavy constant mu Nose + 4.22 0.000
10 ZG16B zymogen granule protein 16B Nose + 3.91 0.000
11 LOC285628 MIR146A host gene Nose + 3.85 0.000
12 CXCL13 chemokine (C-X-C motif) ligand 13 Nose + 3.84 0.001
13 AZGP1 alpha-2-glycoprotein 1, zinc-binding Nose + 3.78 0.001
14 SEC14L3 SEC14-like lipid binding 3 Nose - 3.72 0.000
15 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Nose + 3.70 0.000
16 DSG3 desmoglein 3 Nose + 3.65 0.000
17 DMBT1 deleted in malignant brain tumors 1 Nose + 3.65 0.003
18 SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Nose - 3.61 0.000
19 GREM2 gremlin 2, DAN family BMP antagonist Nose - 3.60 0.002
20 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Nose + 3.55 0.001
21 PRB3 proline-rich protein BstNI subfamily 3 Nose + 3.55 0.001
22 LTF lactotransferrin Nose + 3.49 0.008
23 FLJ26850 FLJ26850 protein Nose - 3.49 0.000
24 NCAPG non-SMC condensin I complex, subunit G Nose + 3.48 0.000
25 DUOX2 dual oxidase 2 Nose + 3.43 0.007
26 MUC5B mucin 5B, oligomeric mucus/gel-forming Nose + 3.41 0.000
27 LPO lactoperoxidase Nose + 3.31 0.003
28 C15orf48 chromosome 15 open reading frame 48 Nose + 3.29 0.001
29 STK33 serine/threonine kinase 33 Nose - 3.28 0.008
30 CXCL5 chemokine (C-X-C motif) ligand 5 Nose + 3.20 0.001
31 CXorf57 chromosome X open reading frame 57 Nose - 3.16 0.002
32 ODAM odontogenic, ameloblast asssociated Nose + 3.12 0.007
33 IDO1 indoleamine 2,3-dioxygenase 1 Nose + 3.11 0.011
34 TF transferrin Nose + 3.11 0.000
35 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) Nose + 3.11 0.003
36 PRB4 proline-rich protein BstNI subfamily 4 Nose + 3.09 0.005
37 LRP1B low density lipoprotein receptor-related protein 1B Nose - 3.06 0.003
38 CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 Nose - 3.04 0.001
Search GEO for disease gene expression data for Sinusitis.

Pathways for Sinusitis

Pathways related to Sinusitis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 BTK CXCL8 DEFB4A IL12RB2 IL4R IL5
2
Show member pathways
13.29 BTK CXCL8 IL12RB2 IL4R IL5 LTC4S
3
Show member pathways
13.06 BTK CXCL8 IL12RB2 IL4R IL5
4
Show member pathways
12.9 BTK CXCL8 IL12RB2 IL4R IL5
5 12.43 CXCL8 IL12RB2 IL4R IL5
6
Show member pathways
12.29 CXCL8 IL12RB2 IL4R IL5 RNASE3
7
Show member pathways
12.09 IL12RB2 IL4R IL5
8
Show member pathways
11.76 CFTR CXCL8 DEFB4A
9
Show member pathways
11.64 BTK CXCL8 IL4R IL5
10
Show member pathways
11.59 CFTR CXCL8 DEFB4A IL5
11 11.21 BTK CXCL8
12 11.01 IL4R IL5
13 10.86 BTK CXCL8 IL5
14 10.46 IL12RB2 IL4R IL5
15 10.16 CYSLTR1 LTC4S

GO Terms for Sinusitis

Biological processes related to Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CXCL8 DEFB4A IL4R IL5
2 peptidyl-tyrosine phosphorylation GO:0018108 9.54 BTK IL12RB2 IL5
3 chemotaxis GO:0006935 9.43 CXCL8 CYSLTR1 DEFB4A
4 antimicrobial humoral response GO:0019730 9.4 DEFB4A RNASE3
5 defense response GO:0006952 9.33 CXCL8 CYSLTR1 DEFB4A
6 cytokine-mediated signaling pathway GO:0019221 9.26 CXCL8 IL12RB2 IL4R IL5
7 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 8.8 CXCL8 DEFB4A RNASE3

Molecular functions related to Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.62 IL12RB2 IL4R

Sources for Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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