MCID: SST003
MIFTS: 22

Sister Chromatid Exchange, Frequency of

Aliases & Classifications for Sister Chromatid Exchange, Frequency of

MalaCards integrated aliases for Sister Chromatid Exchange, Frequency of:

Name: Sister Chromatid Exchange, Frequency of 58
Sce, Frequency of 58

External Ids:

OMIM 58 182220

Summaries for Sister Chromatid Exchange, Frequency of

MalaCards based summary : Sister Chromatid Exchange, Frequency of, also known as sce, frequency of, is related to oral leukoplakia and alcoholic pancreatitis. An important gene associated with Sister Chromatid Exchange, Frequency of is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Affiliated tissues include thyroid, and related phenotype is neoplasm.

Description from OMIM: 182220

Related Diseases for Sister Chromatid Exchange, Frequency of

Diseases related to Sister Chromatid Exchange, Frequency of via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 oral leukoplakia 10.1 GSTM1 XRCC1
2 alcoholic pancreatitis 10.0 ALDH2 CYP2E1
3 differentiated thyroid carcinoma 10.0 CYP2E1 XRCC1
4 alcohol abuse 10.0 ALDH2 CYP2E1
5 respiratory system cancer 9.9 CYP2E1 GSTM1
6 hearing loss, noise-induced 9.9 GSTM1 GSTT1
7 isolated cleft lip 9.9 GSTM1 GSTT1
8 leukoplakia 9.9 GSTM1 GSTT1
9 arteritic anterior ischemic optic neuropathy 9.9 GSTM1 GSTT1
10 ischemic optic neuropathy 9.9 GSTM1 GSTT1
11 diffuse gastric cancer 9.9 GSTM1 GSTT1
12 laryngeal disease 9.9 GSTM1 GSTT1
13 asbestosis 9.9 GSTM1 GSTT1
14 oligospermia 9.9 GSTM1 GSTT1
15 oral submucous fibrosis 9.8 GSTM1 GSTT1
16 varicocele 9.8 GSTM1 GSTT1
17 toxic encephalopathy 9.8 GSTM1 GSTT1
18 bladder disease 9.8 GSTM1 GSTT1
19 oral cancer 9.8 GSTM1 GSTT1
20 pulmonary disease, chronic obstructive 9.8 EPHX1 GSTM1
21 nasopharyngeal carcinoma 9.8 CYP2E1 GSTM1 XRCC1
22 acute lymphocytic leukemia 9.8 GSTM1 GSTT1
23 alcoholic liver cirrhosis 9.8 ALDH2 CYP2E1 GSTM1
24 open-angle glaucoma 9.7 GSTM1 GSTT1
25 cardia cancer 9.7 GSTM1 GSTT1 XRCC1
26 mutagen sensitivity 9.7 GSTM1 GSTT1 XRCC1
27 senile cataract 9.7 GSTM1 GSTT1 XRCC1
28 xeroderma pigmentosum, complementation group d 9.7 GSTM1 GSTT1 XRCC1
29 larynx cancer 9.7 GSTM1 GSTT1 XRCC1
30 large intestine cancer 9.6 GSTM1 GSTT1 XRCC1
31 tobacco addiction 9.6 ALDH2 GSTM1 GSTT1
32 aplastic anemia 9.6 ALDH2 GSTM1 GSTT1
33 cervical cancer 9.6 GSTM1 GSTT1 XRCC1
34 drug-induced hepatitis 9.6 CYP2E1 GSTM1 GSTT1
35 basal cell carcinoma 9.5 GSTM1 GSTT1
36 esophageal cancer 9.5 ALDH2 GSTM1 GSTT1
37 oral cavity cancer 9.3 ALDH2 CYP2E1 GSTM1 GSTT1
38 lung cancer 9.1 CYP2E1 GSTM1 GSTT1 XRCC1

Graphical network of the top 20 diseases related to Sister Chromatid Exchange, Frequency of:



Diseases related to Sister Chromatid Exchange, Frequency of

Symptoms & Phenotypes for Sister Chromatid Exchange, Frequency of

Clinical features from OMIM:

182220

MGI Mouse Phenotypes related to Sister Chromatid Exchange, Frequency of:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ALDH2 CYP2E1 EPHX1 XRCC1

Drugs & Therapeutics for Sister Chromatid Exchange, Frequency of

Search Clinical Trials , NIH Clinical Center for Sister Chromatid Exchange, Frequency of

Genetic Tests for Sister Chromatid Exchange, Frequency of

Anatomical Context for Sister Chromatid Exchange, Frequency of

MalaCards organs/tissues related to Sister Chromatid Exchange, Frequency of:

42
Thyroid

Publications for Sister Chromatid Exchange, Frequency of

Articles related to Sister Chromatid Exchange, Frequency of:

# Title Authors Year
1
Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. ( 12160895 )
2002
2
Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. ( 9838066 )
1998

Variations for Sister Chromatid Exchange, Frequency of

Expression for Sister Chromatid Exchange, Frequency of

Search GEO for disease gene expression data for Sister Chromatid Exchange, Frequency of.

Pathways for Sister Chromatid Exchange, Frequency of

Pathways related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 ALDH2 CYP2E1 EPHX1 GSTM1 GSTT1
2
Show member pathways
12.38 ALDH2 CYP2E1 EPHX1 GSTM1 GSTT1
3 11.62 GSTM1 GSTT1
4
Show member pathways
11.35 CYP2E1 EPHX1 GSTM1 GSTT1
5 11.32 GSTM1 GSTT1
6
Show member pathways
11.24 CYP2E1 EPHX1
7 10.87 GSTM1 GSTT1
8
Show member pathways
10.54 ALDH2 CYP2E1
9 10.3 CYP2E1 EPHX1 GSTM1 GSTT1
10 9.91 CYP2E1 EPHX1 GSTM1

GO Terms for Sister Chromatid Exchange, Frequency of

Cellular components related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 CYP2E1 EPHX1

Biological processes related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.16 CYP2E1 EPHX1
2 glutathione metabolic process GO:0006749 8.96 GSTM1 GSTT1
3 glutathione derivative biosynthetic process GO:1901687 8.62 GSTM1 GSTT1

Molecular functions related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.13 CYP2E1 GSTM1 XRCC1
2 glutathione transferase activity GO:0004364 8.62 GSTM1 GSTT1

Sources for Sister Chromatid Exchange, Frequency of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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