MCID: SST003
MIFTS: 22

Sister Chromatid Exchange, Frequency of

Aliases & Classifications for Sister Chromatid Exchange, Frequency of

MalaCards integrated aliases for Sister Chromatid Exchange, Frequency of:

Name: Sister Chromatid Exchange, Frequency of 57
Sce, Frequency of 57

External Ids:

OMIM 57 182220

Summaries for Sister Chromatid Exchange, Frequency of

MalaCards based summary : Sister Chromatid Exchange, Frequency of, also known as sce, frequency of, is related to oral leukoplakia and alcoholic pancreatitis. An important gene associated with Sister Chromatid Exchange, Frequency of is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Related phenotype is neoplasm.

Description from OMIM: 182220

Related Diseases for Sister Chromatid Exchange, Frequency of

Diseases related to Sister Chromatid Exchange, Frequency of via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 oral leukoplakia 10.3 GSTM1 XRCC1
2 alcoholic pancreatitis 10.3 ALDH2 CYP2E1
3 alcohol abuse 10.1 ALDH2 CYP2E1
4 hearing loss, noise-induced 10.0 GSTM1 GSTT1
5 isolated cleft lip 10.0 GSTM1 GSTT1
6 leukoplakia 10.0 GSTM1 GSTT1
7 arteritic anterior ischemic optic neuropathy 10.0 GSTM1 GSTT1
8 diffuse gastric cancer 10.0 GSTM1 GSTT1
9 asbestosis 9.9 GSTM1 GSTT1
10 oligospermia 9.9 GSTM1 GSTT1
11 ischemic optic neuropathy 9.9 GSTM1 GSTT1
12 respiratory system cancer 9.9 CYP2E1 GSTM1
13 oral submucous fibrosis 9.9 GSTM1 GSTT1
14 varicocele 9.9 GSTM1 GSTT1
15 toxic encephalopathy 9.8 GSTM1 GSTT1
16 oral cancer 9.8 GSTM1 GSTT1
17 sporadic breast cancer 9.8 BRCA1 XRCC1
18 alcoholic liver cirrhosis 9.7 ALDH2 CYP2E1 GSTM1
19 acute lymphocytic leukemia 9.7 GSTM1 GSTT1
20 nasopharyngeal carcinoma 9.6 CYP2E1 GSTM1 XRCC1
21 senile cataract 9.6 GSTM1 GSTT1 XRCC1
22 xeroderma pigmentosum, complementation group d 9.6 GSTM1 GSTT1 XRCC1
23 basal cell carcinoma 9.6 GSTM1 GSTT1 XRCC1
24 oral cavity cancer 9.5 ALDH2 GSTM1 GSTT1
25 tobacco addiction 9.5 ALDH2 GSTM1 GSTT1
26 drug-induced hepatitis 9.5 CYP2E1 GSTM1 GSTT1
27 aplastic anemia 9.5 ALDH2 GSTM1 GSTT1
28 larynx cancer 9.5 GSTM1 GSTT1
29 open-angle glaucoma 9.2 GSTM1 GSTT1
30 esophageal cancer 9.1 ALDH2 GSTM1 GSTT1
31 mutagen sensitivity 8.6 BRCA1 GSTM1 GSTT1 XRCC1

Graphical network of the top 20 diseases related to Sister Chromatid Exchange, Frequency of:



Diseases related to Sister Chromatid Exchange, Frequency of

Symptoms & Phenotypes for Sister Chromatid Exchange, Frequency of

Clinical features from OMIM:

182220

MGI Mouse Phenotypes related to Sister Chromatid Exchange, Frequency of:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 ALDH2 BRCA1 CYP2E1 EPHX1 XRCC1

Drugs & Therapeutics for Sister Chromatid Exchange, Frequency of

Search Clinical Trials , NIH Clinical Center for Sister Chromatid Exchange, Frequency of

Genetic Tests for Sister Chromatid Exchange, Frequency of

Anatomical Context for Sister Chromatid Exchange, Frequency of

Publications for Sister Chromatid Exchange, Frequency of

Articles related to Sister Chromatid Exchange, Frequency of:

# Title Authors Year
1
Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. ( 12160895 )
2002
2
Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. ( 9838066 )
1998

Variations for Sister Chromatid Exchange, Frequency of

Expression for Sister Chromatid Exchange, Frequency of

Search GEO for disease gene expression data for Sister Chromatid Exchange, Frequency of.

Pathways for Sister Chromatid Exchange, Frequency of

Pathways related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 ALDH2 CYP2E1 EPHX1 GSTM1 GSTT1
2
Show member pathways
12.35 ALDH2 CYP2E1 EPHX1 GSTM1 GSTT1
3
Show member pathways
12.34 BRCA1 GSTM1 GSTT1
4 11.36 BRCA1 GSTM1 GSTT1
5
Show member pathways
11.35 CYP2E1 EPHX1 GSTM1 GSTT1
6 11.34 BRCA1 XRCC1
7
Show member pathways
11.2 CYP2E1 EPHX1
8 10.9 GSTM1 GSTT1
9
Show member pathways
10.58 ALDH2 CYP2E1
10 10.3 CYP2E1 EPHX1 GSTM1 GSTT1
11 9.91 CYP2E1 EPHX1 GSTM1

GO Terms for Sister Chromatid Exchange, Frequency of

Cellular components related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 CYP2E1 EPHX1

Biological processes related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.32 CYP2E1 EPHX1
2 double-strand break repair via homologous recombination GO:0000724 9.26 BRCA1 XRCC1
3 double-strand break repair via nonhomologous end joining GO:0006303 9.16 BRCA1 XRCC1
4 glutathione metabolic process GO:0006749 8.96 GSTM1 GSTT1
5 glutathione derivative biosynthetic process GO:1901687 8.62 GSTM1 GSTT1

Molecular functions related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 9.16 BRCA1 XRCC1
2 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
3 enzyme binding GO:0019899 8.92 BRCA1 CYP2E1 GSTM1 XRCC1

Sources for Sister Chromatid Exchange, Frequency of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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