MCID: SST003
MIFTS: 24

Sister Chromatid Exchange, Frequency of

Aliases & Classifications for Sister Chromatid Exchange, Frequency of

MalaCards integrated aliases for Sister Chromatid Exchange, Frequency of:

Name: Sister Chromatid Exchange, Frequency of 57
Sce, Frequency of 57

External Ids:

OMIM® 57 182220

Summaries for Sister Chromatid Exchange, Frequency of

MalaCards based summary : Sister Chromatid Exchange, Frequency of, also known as sce, frequency of, is related to lung cancer and leukemia, chronic myeloid. An important gene associated with Sister Chromatid Exchange, Frequency of is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Affiliated tissues include myeloid, whole blood and bone marrow, and related phenotype is neoplasm.

More information from OMIM: 182220

Related Diseases for Sister Chromatid Exchange, Frequency of

Diseases related to Sister Chromatid Exchange, Frequency of via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 lung cancer 10.2
2 leukemia, chronic myeloid 10.2
3 myeloid leukemia 10.2
4 leukoplakia 10.1 GSTT1 GSTM1
5 hearing loss, noise-induced 10.1 GSTT1 GSTM1
6 thyroid tumor 10.1 GSTT1 GSTM1
7 isolated cleft lip 10.1 GSTT1 GSTM1
8 beta-thalassemia major 10.0 GSTT1 GSTM1
9 asbestosis 10.0 GSTT1 GSTM1
10 diffuse gastric cancer 10.0 GSTT1 GSTM1
11 xeroderma pigmentosum, complementation group d 10.0 XRCC1 GSTM1
12 toxic encephalopathy 10.0 GSTM1 EPHX1
13 herpes simplex 10.0
14 oral cancer 10.0 GSTT1 GSTM1
15 oligospermia 10.0 GSTT1 GSTM1
16 trimethoprim allergy 9.9 GSTM1 CYP2E1
17 bronchitis 9.9 GSTM1 EPHX1
18 female breast cancer 9.9 XRCC1 ALDH2
19 drug-induced hepatitis 9.9 GSTM1 CYP2E1
20 polyneuropathy due to drug 9.9 EPHX1 CYP2E1
21 colorectal adenoma 9.8 XRCC1 GSTM1 EPHX1
22 oral leukoplakia 9.8 XRCC1 GSTT1 GSTM1
23 mutagen sensitivity 9.8 XRCC1 GSTT1 GSTM1
24 gastroesophageal adenocarcinoma 9.8 XRCC1 GSTT1 GSTM1
25 senile cataract 9.8 XRCC1 GSTT1 GSTM1
26 methanol poisoning 9.8 CYP2E1 ALDH2
27 larynx cancer 9.8 XRCC1 GSTT1 GSTM1
28 alcoholic cardiomyopathy 9.8 CYP2E1 ALDH2
29 porphyria cutanea tarda 9.8 GSTM1 CYP2E1
30 substance dependence 9.7 GSTM1 ALDH2
31 fetal alcohol spectrum disorder 9.7 CYP2E1 ALDH2
32 fetal alcohol syndrome 9.7 CYP2E1 ALDH2
33 basal cell carcinoma 9.7 XRCC1 GSTT1 GSTM1
34 alcoholic hepatitis 9.7 CYP2E1 ALDH2
35 substance abuse 9.6 CYP2E1 ALDH2
36 childhood acute lymphocytic leukemia 9.6 XRCC1 GSTM1 CYP2E1
37 motor neuron disease 9.6 GSTT1 GSTM1 CYP2E1
38 alcoholic pancreatitis 9.6 GSTM1 CYP2E1 ALDH2
39 alcoholic liver cirrhosis 9.6 GSTM1 CYP2E1 ALDH2
40 oral cavity cancer 9.6 GSTM1 CYP2E1 ALDH2
41 lynch syndrome 9.5 XRCC1 GSTT1 GSTM1 EPHX1
42 nasopharyngeal carcinoma 9.5 XRCC1 GSTM1 CYP2E1
43 alcohol use disorder 9.4 CYP2E1 ALDH2
44 cardia cancer 9.4 XRCC1 GSTT1 GSTM1 CYP2E1
45 aplastic anemia 9.1 GSTT1 GSTM1 EPHX1 CYP2E1 ALDH2
46 esophageal cancer 9.0 XRCC1 GSTM1 EPHX1 CYP2E1 ALDH2
47 tobacco addiction 8.8 XRCC1 GSTT1 GSTM1 EPHX1 CYP2E1 ALDH2

Graphical network of the top 20 diseases related to Sister Chromatid Exchange, Frequency of:



Diseases related to Sister Chromatid Exchange, Frequency of

Symptoms & Phenotypes for Sister Chromatid Exchange, Frequency of

Clinical features from OMIM®:

182220 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Sister Chromatid Exchange, Frequency of:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ALDH2 CYP2E1 EPHX1 XRCC1

Drugs & Therapeutics for Sister Chromatid Exchange, Frequency of

Search Clinical Trials , NIH Clinical Center for Sister Chromatid Exchange, Frequency of

Genetic Tests for Sister Chromatid Exchange, Frequency of

Anatomical Context for Sister Chromatid Exchange, Frequency of

MalaCards organs/tissues related to Sister Chromatid Exchange, Frequency of:

40
Myeloid, Whole Blood, Bone Marrow, Liver, Lung, Monocytes, Thyroid

Publications for Sister Chromatid Exchange, Frequency of

Articles related to Sister Chromatid Exchange, Frequency of:

(show all 45)
# Title Authors PMID Year
1
A family study of spontaneous sister chromatid exchange frequency. 57
7072718 1982
2
Similar Sister Chromatid Arrangement in Mono- and Holocentric Plant Chromosomes. 61
27454585 2016
3
Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes. 61
19482912 2009
4
The genotoxicity and cytotoxicity among patients diagnosed with organophosphate poisoning. 61
19750985 2009
5
Sister chromatid exchange (SCE) analysis in periodontitis. 61
12423293 2002
6
Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. 61
12160895 2002
7
Effect of dioxins in mother's milk on sister chromatid exchange frequency in infant lymphocytes. 61
11452515 2001
8
A comparative study of genotoxic effects in the treatment of trichomonas vaginalis infection: metronidazole or nalidixic acid. 61
10985613 2000
9
Monocytes affect cell-cycle progression but not baseline frequency of sister chromatid exchanges of pig lymphocytes. 61
10037327 1999
10
Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. 61
9838066 1998
11
Sister chromatid exchange in Chinese newborn infants treated with phototherapy for more than five days. 61
9823679 1998
12
[Effects of SAD on cytogenetics of mouse embryonic cells and its embryo development]. 61
9414574 1997
13
Field bean protease inhibitor mitigates the sister-chromatid exchanges induced by bromoform and depresses the spontaneous sister-chromatid exchange frequency of human lymphocytes in vitro. 61
8657207 1996
14
Sister chromatid exchanges in the peripheral lymphocytes of newborns with Down syndrome after in vitro exposure to blue or green light. 61
8628334 1996
15
Recombinant human granulocyte colony-stimulating factor does not influence distribution or sister chromatid exchange frequency of proliferating mononuclear cells of the peripheral blood. 61
7536318 1995
16
Effect of Viscum album L. on rapidly proliferating amniotic fluid cells. Sister chromatid exchange frequency and proliferation index. 61
7893276 1995
17
SCE frequency of herpes simplex virus type I infected cells. 61
7512205 1994
18
Intervention study on the influence of reduction of occupational exposure to styrene on sister chromatid exchanges in lymphocytes. 61
7814095 1994
19
Viscum album L. extracts reduce sister chromatid exchanges in cultured peripheral blood mononuclear cells. 61
7880615 1994
20
A study of sister chromatid exchange and somatic cell mutation in hospital workers exposed to ethylene oxide. 61
8143611 1993
21
Sister chromatid exchanges in peripheral lymphocytes in newborns treated with phototherapy and vitamin E. 61
1421889 1992
22
Cytogenetic mechanisms in the selective toxicity of cyclophosphamide analogs and metabolites towards avian embryonic B lymphocytes in vivo. 61
1378178 1992
23
Effect of acrolein on phosphoramide mustard-induced sister chromatid exchanges in cultured human lymphocytes. 61
2369740 1990
24
Genotoxicity of coal fly ash, assessed in vitro in Salmonella typhimurium and human lymphocytes, and in vivo in an occupationally exposed population. 61
2671713 1989
25
Effect of betel chewing on the frequency of sister chromatid exchanges in pregnant women and women using oral contraceptives. 61
3365681 1988
26
Effects of 5-bromo-2-deoxyuridine concentration and alpha-naphthoflavone on the association between smoking and the frequency of sister-chromatid exchanges in lymphocytes from maternal and cord blood. 61
3600688 1987
27
Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation. 61
3803323 1987
28
Increased sister-chromatid exchange frequency in preimplantation mouse embryos after maternal cyclophosphamide treatment before implantation. 61
3738933 1986
29
Cell cycle progression and SCE rate of Bloom syndrome cells with/without co-cultivation in the presence/absence of normal cells. 61
3485532 1986
30
Attenuation of cytogenetic damage by 2-mercaptoethanesulfonate in cultured human lymphocytes exposed to cyclophosphamide and its reactive metabolites. 61
3079586 1986
31
Variation in sister chromatid exchange frequencies between human and pig whole blood, plasma leukocyte, and mononuclear leukocyte cultures. 61
3732196 1986
32
Sister-chromatid exchanges and chromosomal aberrations in a population exposed to pesticides. 61
4022025 1985
33
Changes in spontaneous SCE frequencies as a function of sampling time in lymphocytes from normal donors and cancer patients. 61
4000153 1985
34
[Sister chromatid exchange frequency of bone marrow cells and its response to indirubin in chronic myeloid leukemia]. 61
6598442 1984
35
Influence of a constant magnetic field on human lymphocyte cultures. 61
6477746 1984
36
SCEs are induced by replication of BrdU-substituted DNA templates, but not by incorporation of BrdU into nascent DNA. 61
6738570 1984
37
[Effects of benzo(a)pyrene metabolites from rat liver S9 fraction on sister chromatid exchange frequency of lymphocytes]. 61
6242356 1984
38
Different properties in lymphoblastoid cell lines from patients with Bloom syndrome. 61
6099120 1984
39
Correlation of human lymphocyte SCE frequency with smoking history. 61
6823226 1983
40
Effect of mitomycin C, hydroxylamine & bromodeoxyuridine on cell cycle kinetics & sister chromatid exchange frequency of muntjac lymphocytes. 61
6819223 1982
41
Sister-chromatid exchange induction by sodium selenite: plasma protein-bound selenium is not the active SCE-inducing metabolite of Na2SeO3. 61
7144784 1982
42
Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates. 61
6981766 1982
43
Selective differential staining of sister chromatids of the facultative heterochromatic X chromosome in the female mouse. 61
7327046 1981
44
X irradiation and sister chromatid exchange in cultured human lymphocytes. 61
7327164 1980
45
Effect of sodium selenite and methyl methanesulfonate or N-hydroxy-2-acetylaminofluorene co-exposure on sister-chromatid exchange production in human whole blood cultures. 61
209327 1978

Variations for Sister Chromatid Exchange, Frequency of

Expression for Sister Chromatid Exchange, Frequency of

Search GEO for disease gene expression data for Sister Chromatid Exchange, Frequency of.

Pathways for Sister Chromatid Exchange, Frequency of

Pathways related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 GSTT1 GSTM1 EPHX1 CYP2E1 ALDH2
2
Show member pathways
12.39 GSTT1 GSTM1 EPHX1 CYP2E1 ALDH2
3 11.64 GSTT1 GSTM1
4
Show member pathways
11.44 CYP2E1 ALDH2
5
Show member pathways
11.35 GSTT1 GSTM1 EPHX1 CYP2E1
6 11.32 GSTT1 GSTM1
7
Show member pathways
11.24 EPHX1 CYP2E1
8 10.87 GSTT1 GSTM1
9
Show member pathways
10.54 CYP2E1 ALDH2
10 10.3 GSTT1 GSTM1 EPHX1 CYP2E1
11 9.91 GSTM1 EPHX1 CYP2E1

GO Terms for Sister Chromatid Exchange, Frequency of

Cellular components related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.62 EPHX1 CYP2E1

Biological processes related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.16 EPHX1 CYP2E1
2 glutathione metabolic process GO:0006749 8.96 GSTT1 GSTM1
3 glutathione derivative biosynthetic process GO:1901687 8.62 GSTT1 GSTM1

Molecular functions related to Sister Chromatid Exchange, Frequency of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.13 XRCC1 GSTM1 CYP2E1
2 glutathione transferase activity GO:0004364 8.62 GSTT1 GSTM1

Sources for Sister Chromatid Exchange, Frequency of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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